WSCS 2014: REGENERATIVE MEDICINE: A NEW ERA OF DISCOVERY AND INNOVATION
Moderator - John Sterling, Genetic Engineering Biotechnology News Speakers - Marie Csete, MD, PhD, Huntington Medical Research Institute Aubrey de Grey, ...
By: worldstemcell
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WSCS 2014: REGENERATIVE MEDICINE: A NEW ERA OF DISCOVERY AND INNOVATION - Video
WSCS 2014: REGENERATIVE MEDICINE FOR AGING: MAKING REJUVENATION COMPREHENSIVE NOT COSMETIC
Presenter - Aubrey de Grey, PhD, SENS Foundation.
By: worldstemcell
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WSCS 2014: REGENERATIVE MEDICINE FOR AGING: MAKING REJUVENATION COMPREHENSIVE NOT COSMETIC - Video
How do Stemnexa Stem Cell Procedures Heal Orthopedic Damage? - Dr. Wade McKenna, Orthopedic Surgeon
Board-Certified Orthopedic Surgeon, Dr. McKenna explains how Stemnexa bone marrow stem cells augmented with AlphaGEMS amniotic tissue product works in the human body to heal damage ...
By: Riordan-McKenna Institute
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How do Stemnexa Stem Cell Procedures Heal Orthopedic Damage? - Dr. Wade McKenna, Orthopedic Surgeon - Video
Patient credits stem cells for repairing her meniscus!
http://www.RejuvMedical.com/pages/StemCellTreatments This patient claims a 95% recovery to her knee just three months after her Stem Cell Treatment in Saint ...
By: Rejuv Medical
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Patient credits stem cells for repairing her meniscus! - Video
Understanding Stem Cell Research: What are stem cells?
Durham CELLS (Centre for Ethics and Law in the Life Sciences) with the support of the Wellcome Trust organised activities to prepare post-16 students for a m...
By: DurhamUniversity
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Understanding Stem Cell Research: What are stem cells? - Video
Intestinal Stem Cells Part 5
In this video we discuss the role of intestinal stem cells in the tissue renewal of the intestinal epithelium.
By: Ben Garside
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Intestinal Stem Cells Part 5 - Video
Phytoscience Double Stemcell - Naturally Reverse Your Biological Clock
PhytoScience Double Stem Cell powder, a delicious proprietary blend of the signature stem cell extracts: - PhytoCellTec Malus Domestica (Apple Stem Cells) - PhytoCellTec Solar Vitis...
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Phytoscience Double Stemcell - Naturally Reverse Your Biological Clock - Video
How PhytoCellTec Solar Vitis Works - Skin UV protection Stem Cell
Solar Vitis is based on stem cells from the GamayTeinturierFraux grape - a grape of Burgundy, which is characterized by an extremely high content of polyphenols for UV protection that has...
By: NetBiz GlobalMarketing
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How PhytoCellTec Solar Vitis Works - Skin UV protection Stem Cell - Video
Stem Cell Sound Bites: Duchenne Muscular Dystrophy
Visit: http://www.uctv.tv/) Carrie Miceli and Stanley Nelson of UCLA describe their efforts to use stem cell-based strategies to find a drug treatment for d...
By: University of California Television (UCTV)
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Stem Cell Sound Bites: Duchenne Muscular Dystrophy - Video
P-SPAN #411: "Treating Blindness with Stem Cells"
On February 5, 2015, the Science/Biotechnology Department at Berkeley City College kicked off their Spring 2015 Seminar Series, sponsored by the California Institute for Regenerative Medicine....
By: Peralta Colleges
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P-SPAN #411: "Treating Blindness with Stem Cells" - Video
Healing Tendon Tears, Ligamentous Tears and Sprains with Stem Cell Therapy
For more information: http://www.rmiclinic.com or 877-899-7836 (toll-free) Board Certified Orthopedic Surgeon discusses treating tendon tears, ligament tears and sprains with Stemnexa, a proprietary...
By: Riordan-McKenna Institute
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Healing Tendon Tears, Ligamentous Tears and Sprains with Stem Cell Therapy - Video
Florida panther receives Stem Cell Therapy
Florida Panther Gets Stem Cell Therapy at Newman Veterinary Centers in Florida.
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Florida panther receives Stem Cell Therapy - Video
Stem cell therapy in AKI Dr Mohamed Kamal
Stem cell therapy in AKI Dr Mohamed Kamal.
By: HusseinSheashaa
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Stem cell therapy in AKI Dr Mohamed Kamal - Video
When it comes to gene expression -- the process by which our DNA provides the recipe used to direct the synthesis of proteins and other molecules that we need for development and survival -- scientists have so far studied one single gene at a time. A new approach developed by Harvard geneticist George Church, Ph.D., can help uncover how tandem gene circuits dictate life processes, such as the healthy development of tissue or the triggering of a particular disease, and can also be used for directing precision stem cell differentiation for regenerative medicine and growing organ transplants.
The findings, reported by Church and his team of researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School in Nature Methods, show promise that precision gene therapies could be developed to prevent and treat disease on a highly customizable, personalized level, which is crucial given the fact that diseases develop among diverse pathways among genetically-varied individuals. Wyss Core Faculty member Jim Collins, Ph.D., was also a co-author on the paper. Collins is also the Henri Termeer Professor of Medical Engineering & Science and Professor in the Department of Biological Engineering at the Massachusetts Institute of Technology.
The approach leverages the Cas9 protein, which has already been employed as a Swiss Army knife for genome engineering, in a novel way. The Cas9 protein can be programmed to bind and cleave any desired section of DNA -- but now Church's new approach activates the genes Cas9 binds to rather than cleaving them, triggering them to activate transcription to express or repress desired genetic traits. And by engineering the Cas9 to be fused to a triple-pronged transcription factor, Church and his team can robustly manipulate single or multiple genes to control gene expression.
"In terms of genetic engineering, the more knobs you can twist to exert control over the expression of genetic traits, the better," said Church, a Wyss Core Faculty member who is also Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. "This new work represents a major, entirely new class of knobs that we could use to control multiple genes and therefore influence whether or not specific genetics traits are expressed and to what extent -- we could essentially dial gene expression up or down with great precision."
Such a capability could lead to gene therapies that would mitigate age-related degeneration and the onset of disease; in the study, Church and his team demonstrated the ability to manipulate gene expression in yeast, flies, mouse and human cell cultures.
"We envision using this approach to investigate and create comprehensive libraries that document which gene circuits control a wide range of gene expression," said one of the study's lead authors Alejandro Chavez, Ph.D., Postdoctoral Fellow at the Wyss Institute. Jonathan Schieman, Ph.D, of the Wyss Institute and Harvard Medical School, and Suhani Vora, of the Wyss Institute, Massachusetts Institute of Technology, and Harvard Medical School, are also lead co-authors on the study.
The new Cas9 approach could also potentially target and activate sections of the genome made up of genes that are not directly responsible for transcription, and which previously were poorly understood. These sections, which comprise up to 90% of the genome in humans, have previously been considered to be useless DNA "dark matter" by geneticists. In contrast to translated DNA, which contains recipes of genetic information used to express traits, this DNA dark matter contains transcribed genes which act in mysterious ways, with several of these genes often having influence in tandem.
But now, that DNA dark matter could be accessed using Cas9, allowing scientists to document which non-translated genes can be activated in tandem to influence gene expression. Furthermore, these non-translated genes could also be turned into a docking station of sorts. By using Cas9 to target and bind gene circuits to these sections, scientists could introduce synthetic loops of genes to a genome, therefore triggering entirely new or altered gene expressions.
The ability to manipulate multiple genes in tandem so precisely also has big implications for advancing stem cell engineering for development of transplant organs and regenerative therapies.
"In order to grow organs from stem cells, our understanding of developmental biology needs to increase rapidly," said Church. "This multivariate approach allows us to quickly churn through and analyze large numbers of gene combinations to identify developmental pathways much faster than has been previously capable."
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Activating genes on demand: Possible?
Orthopedic Stem Cell Therapy From Bone Marrow
Stem Cell therapy derived from bone marrow is the latest in modern orthopedic medicine to help you alleviate severe joint pain, and avoid invasive joint repl...
By: Cross Bay Physical Medicine and Rehabilitation, P.C.
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Orthopedic Stem Cell Therapy From Bone Marrow - Video
Using Stem Cell Therapy to Repair Damaged Tissue from Shoulder Impingement Syndrome
Board Certified Orthopedic Surgeon, Dr. Wade McKenna discusses how Stemnexa stem cell therapy and amniotic tissue product can aid in healing frayed shoulder ...
By: Riordan-McKenna Institute
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Using Stem Cell Therapy to Repair Damaged Tissue from Shoulder Impingement Syndrome - Video
Stem Cell Therapy for Bone Fractures - Board-Certified Orhopedic Surgeon, Wade McKenna DO
Dr. McKenna discusses how bone fractures, including non-union fractures can be treated non-surgically with a the patient #39;s own bone marrow stem cells augmented with AlphaGEMS amniotic tissue...
By: Riordan-McKenna Institute
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Stem Cell Therapy for Bone Fractures - Board-Certified Orhopedic Surgeon, Wade McKenna DO - Video
Overcoming Knee Replacement Surgery Faster Using Amniotic Tissue-Enhanced Stem Cell Therapy
Dr. McKenna discusses how the addition of a patient #39;s own bone marrow stem cells combined with AlphaGEMS amniotic tissue product helps patients recover faster from a total knee replacement ...
By: Riordan-McKenna Institute
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Overcoming Knee Replacement Surgery Faster Using Amniotic Tissue-Enhanced Stem Cell Therapy - Video
Knee arthritis one year after stem cell therapy by Harry Adelson, N.D.
Frank describes his outcome one year after stem cell therapy for his arthritic knee by Harry Adelson, N.D. http://www.docereclinics.com.
By: Harry Adelson, N.D.
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Knee arthritis one year after stem cell therapy by Harry Adelson, N.D. - Video
stem cell therapy helps avoiding knee surgery
Meet John Tucker, he suffered from Osteoarthritis in his knee. Watch our live video to hear John #39;s experience with Stem Cells! RMG is also proud to announce we are offering at 100% Knee Guarantee!
By: iManifestart