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What is Arthritis | Arthritis Center | Boston Medical …

October 4th, 2015 10:46 am

Arthritis Center

The Rheumatology/Arthritis department at Boston Medical Center is part of the world-renowned Boston University Arthritis Center, affiliated with the Boston University School of Medicine. We are an international referral center for the diagnosis and treatment of all rheumatic disorders with a special focus on scleroderma, vasculitis, osteoarthritis and amyloidosis.

Our expertise and active research programs, our long and distinguished history of training prominent rheumatologists, and our comprehensive, multidisciplinary approach have made us leaders in the field. We are committed to meeting the health needs of our local community and beyond, and to providing prompt, exceptional care to our patients.

We are located in Boston Medical Centers beautiful Shapiro Center in Bostons historic South End.

BMC has a special focus on scleroderma, vasculitis, osteoarthritis and amyloidosis disorders.

Call: 617.638.7460 Fax: 617.638.5226

Boston Medical Center Arthritis Center / Rheumatology Shapiro Center 7th Floor, Suite 7B 725 Albany Street Boston, MA 02118

Call: 617.638.7774 Refills will be processed within 48 hours.

Call: 617.638.4310 Fax: 617.638.7454

Call: 617.638.4310

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Arthritis News Topix

October 4th, 2015 10:46 am

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Arthritis of the Hip – Types, Symptoms, Diagnosis, Treatment

October 4th, 2015 10:46 am

Arthritis is one of the most common causes of pain in the hip. Arthritis is a progressive disorder, which means that it typically starts gradually and gets worse with time. The term arthritis literally means inflammation of the joint.

There are different types of arthritis that can affect the hip. The type of arthritis you have may affect your treatment options.

Types of Arthritis

There are five main types of arthritis that can affect the hip joint. They are:

There is no cure for any type of arthritis, but there are ways to treat the pain and other associated symptoms.

Osteoarthritis

Osteoarthritis means arthritis of the bone and is the most common form of arthritis. It is often described as the result of wear and tear on the joints, which explains why it is more common in older than younger people.

The hip joint consists of the ball-shaped end of the thigh bone (femoral head) which fits into the hip socket (acetabular socket). The inside of this ball-and-socket joint is lined with smooth cartilage to help the joint move easily. If this smooth cartilage wears away, the remaining rough surfaces of the ball-and-socket grind against each other, causing pain. Over time, osteoarthritis can degenerate or permanently damage the joint.

Osteoarthritis of the hip (and other parts of the body) has been associated with the following:

However, osteoarthritis may develop in people without these risk factors.

Figure a

Figure b

Two radiographs of a female patient showing acetabular dysplasia (a shallow hip socket). The patient started to have hip pain when she was 20 years-old (a). This hip dysplasia was not treated and 15 years later she had end-stage osteoarthritis of the hip (b). Note the complete loss of cartilage joint space between the ball and the socket over this 15-year interval.

Rheumatoid Arthritis

Rheumatoid arthritis is a systemic disorder, that is, it affects your entire body and not just the hip joint. The inflammation is related to an immune system response rather than wear and tear.

The hip joint, like other joints in the body, is protected by a special capsule that completely surrounds the joint. This capsule has a special lining (the synovial lining) and is filled with lubricant (joint fluid) that helps the joint move smoothly. Rheumatoid arthritis typically causes a swelling of the synovial lining. This causes pain and swelling, but eventually, rheumatoid arthritis can cause the bone and cartilage of the joint itself to deteriorate.

Rheumatoid arthritis can occur in people of all ages, including children (where it is known as juvenile rheumatoid arthritis), and is more common in women than men. Unlike osteoarthritis of the hip, which may occur only in one hip, rheumatoid arthritis typically occurs in both hips at the same time (and possibly other joints). Rheumatoid arthritis is also associated with overall weakness and fatigue. Medications to treat rheumatoid arthritis continue to improve.

Ankylosing spondylitis

Ankylosing spondylitis is a chronic inflammation of the spine and sacroiliac joint (the joint where the spine meets the pelvis) which can sometimes cause inflammation of the hip joint. Ankylosing spondylitis can occur in people of all ages, including children, and typically starts in a person between the ages of 17 and 35. It is more common in men than women.

It is typical for people with ankylosing spondylitis to experience flares, when the condition is worse, followed by periods of remission with mild to no symptoms.

Systemic Lupus Erythematosus

Systemic lupus erythematosus or lupus is a systemic autoimmune disorder that can affect any part of the body, including the hip joint. If lupus strikes the hip, inflammation and damage to the joint can occur. Lupus can occur in people of all ages but it is most common in women aged 15 to 35.

Psoriatic Arthritis

As the name sounds, this type of arthritis is related to the skin condition psoriasis. Psoriatic arthritis causes joint pain, swelling, and stiffness and can affect any joint in the body, including the hip. Most people with psoriatic arthritis have the skin condition first (scaly red patches of skin) but it is possible to develop psoriatic arthritis before the skin condition occurs.

Arthritis Symptoms

Regardless of the type of arthritis, symptoms of hip arthritis include:

In patients with rheumatoid arthritis or lupus, fatigue and weakness may also occur. Arthritis often occurs in flares with remission, but some people experience a relatively stable level of pain without flares.

Any type of arthritis can involve more than one joint in the body, so a person with osteoarthritis of the hands may develop the condition in the hip as well. Rheumatoid arthritis and lupus typically affect both hips at the same time, while osteoarthritis and psoriatic arthritis may occur in one hip but not the other.

Diagnosis

If you suspect you may have arthritis of the hip, the most important first step is an accurate diagnosis. Dr. Clohisy and his colleagues are experts in arthritis of the hip. A diagnostic evaluation will likely include the following:

Treatment

The Joint Preservation, Resurfacing and Replacement department will prescribe the type of treatment that is appropriate for your particular type of arthritis and other factors, including your overall health, your age, and your personal preferences.

Nonsurgical treatment of arthritis of the hip may include any of the following:

Lifestyle modifications can also help to reduce the symptoms of arthritis of the hip. These include:

Many people with arthritis with the hip are candidates for surgery. Surgery can help to reduce pain, enhance quality of life, and improve your ability to perform everyday activities with fewer or no restrictions.

If you are an appropriate candidate for hip surgery, the risks and benefits of your surgical options will be discussed.

Important Considerations for People with Arthritis of the Hip

There is no cure for arthritis. Typically, it starts gradually and worsens over time. Eventually, all forms of arthritis of the hip may permanently damage the hip joint. While osteoarthritis is more common in older people, there are forms of arthritis that affect younger people.

Fortunately, there are things that can be done to help minimize the effect of arthritis, and we are glad to discuss these option.

Arthritis Statistics

(Statistics from Centers for Disease Control and Prevention)

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Boston Rheumatoid Arthritis Services | Arthritis Center …

October 4th, 2015 10:46 am

The Rheumatology/Arthritis Department at BMC diagnoses and treats the full range of rheumatological and arthritic diseases and conditions.

Arthritis, Connective Tissue and Autoimmune Diseases Rheumatoid Arthritis Scleroderma Vasculitis Lupus Amyloidosis Osteoarthritis Other Rheumatic Conditions

Arthritis, Connective Tissue and Autoimmune Diseases

In the broad field of arthritic and rheumatic conditions, our rheumatologists have earned an international reputation for their leadership in treatment, research and education. Because there are so many types of arthritic conditions, successful treatment depends on the highly accurate diagnostic services we provide.

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Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is the most common autoimmune disease to cause chronic inflammatory arthritis. We have been at the forefront in developing practice guidelines for the management of rheumatoid arthritis and monitoring its therapy. We can evaluate patients for appropriateness of less common therapy and work with you to manage it. We pioneered a unique, highly accurate system for measuring the progress of arthritis patients based on their own assessment of pain and disability. This type of outcome-oriented approach is now widely used at other arthritis centers.

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Scleroderma Disease

Scleroderma is an autoimmune disease which causes fibrosis of the skin and internal organs. The Scleroderma Center is a collaboration of the Pulmonary and Rheumatology Departments. The Center is recognized internationally as a leader in scleroderma, and provides for the diagnosis and treatment of patients with Systemic Sclerosis.

Our scleroderma program, the largest in New England, offers the latest diagnostic and therapeutic measures available. We take a multidisciplinary approach for comprehensive evaluation and treatment of patients with all forms of scleroderma, with specialists in cardiology, pulmonology, dermatology, radiology, urology and others as needed. Our extensive research in this area includes exploration of basic connective tissue biology and evaluation of medications through clinical trials. Our program is a member of the Scleroderma Clinical Trials Consortium.

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Vasculitis Disease

Vasculitis is an autoimmune disease causing inflammation of blood vessels with organ and life threatening consequences. We have pioneered the development of the NIH sponsored Vasculitis Clinical Research Consortium. We offer internationally recognized expertise in the evaluation and treatment of all forms of vasculitis.

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Lupus Disease

Lupus is a multisystem autoimmune disease causing damage to multiple body organs, including joints, kidneys, skin, brain and others. Members of our staff helped develop the nationally accepted classification of systemic lupus erythematosus, which has made this formerly elusive connective tissue disease easier to diagnose. We pioneered various treatments for lupus, particularly at the stage when the disease begins to affect the kidneys. We work together with other specialists at Boston Medical Center to treat all the manifestations of this multi-system disease. Our active research efforts include clinical and epidemiological studies.

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Amyloidosis

Boston Medical Center is an international referral center for the diagnosis and treatment of all forms of amyloidosis, a rare group of diseases caused by the abnormal accumulation of the protein amyloid in various parts of the body. We are one of only two centers nationwide that treat amyloidosis, and take a multidisciplinary approach to this multi-organ disorder. We coordinate our diagnosis and innovative treatments with other specialists at BMC, streamlining the process for the patient. Although amyloidosis is not cancer, the Center for Cancer and Blood Disorders at BMC pioneered the use of stem cell transplantation to successfully treat the primary form of the disease. Visit our Amyloid Treatment and Research Program website for more information.

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Osteoarthritis

Our arthritis specialists are among the nations leading researchers into osteoarthritis, also known as degenerative joint disease. We helped define the role of weight loss and exercise in osteoarthritis treatment and have begun to study the effect of diet and nutritional supplements on symptoms. We work closely with orthopedic specialists at the Boston University Arthritis Center to help patients decide if they need surgery.

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Other Rheumatic Conditions

We also offer diagnosis and treatment for soft tissue rheumatism including Raynauds disease, bursitis and tendonitis, shoulder, neck and knee problems, gout, and other disorders of bones, joints and muscles. We offer bedside musculoskeletal ultrasound imaging to help obtain faster diagnoses and deliver safer and more effective therapy. Other conditions in which we have expertise are infectious arthritis and Lyme disease. We are collaborating with colleagues in dermatology to provide cutting edge care for patients with psoriatic arthritis.

Whatever the diagnosis and treatment, we provide state-of-the art diagnostic and therapeutic services including musculoskeletal ultrasound, joint aspiration and injection, and diagnostic radiology. We also offer full service physical and occupational therapy when indicated.

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Arthritis – The University of Chicago Medicine

October 4th, 2015 10:46 am

Arthritis and other rheumatic diseases are characterized by pain, swelling, and limited movement in joints and connective tissues in the body. According to the Centers for Disease Control and Prevention, nearly50 million people in the US have some form of arthritis or chronic joint symptoms.

Arthritis, which literally means inflammation of a joint (where two or more bones meet), actually refers to more than 100 different diseases. Rheumatic diseases include any diseases that cause pain, stiffness, and swelling in joints or other supportive body structures, such as muscles, tendons, ligaments, and bones.

Arthritis and other rheumatic diseases are often mistakenly associated with old age, because osteoarthritis (the most common form of arthritis) occurs more often among elderly persons. However, arthritis and other rheumatic diseases affect people of all ages.

Arthritis is usually chronic, which means that it rarely changes, or it progresses slowly. Specific causes for most forms of arthritis are not yet known.

Joints are the areas where two bones meet. Most joints are mobile, allowing the bones to move. Joints consist of the following:

The three most prevalent forms of arthritis include the following:

The following are the most common symptoms of arthritis. However, each individual may experience symptoms differently. Symptoms may include:

The symptoms of arthritis may resemble other medical conditions or problems. Always consult your physician for a diagnosis.

In addition to a complete medical history and physical examination, diagnostic procedures for arthritis may include the following:

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Arthritis - The University of Chicago Medicine

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Home Remedies for Arthritis in Hands | Top 10 Home Remedies

October 4th, 2015 10:46 am

Arthritis in the hands is the most common type of arthritis. It occurs as a result of the breakdown of the cartilage that support the bone structure.

Since we use our hands and fingers in most activities, arthritis in the hands can be a cause of discomfort and uneasiness. Swollen fingers, joint inflammation, stiffness and pain are some of the symptoms of hand arthritis.

Advancements in the medical field have led to the development of many methods for controlling the various arthritis symptoms. Along with medications, you can also try some easy yet highly effective natural remedies to improve the condition of your fingers and hands.

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Here are the top 10 home remedies for arthritis in the hands. Also, consult your doctor for proper diagnosis and treatment.

Cold therapy is good for those suffering from hand arthritis. You can use ice packs, a plastic bag filled with crushed ice or a bag of frozen vegetables. Regular application of ice packs on the affected hands and fingers will lessen irritation and reduce soreness. However, it is important to bear in mind that different people may respond differently to cold therapy.

Simply put the ice pack on the affected area for a few minutes and then repeat. Continue this home treatment for about 20 minutes, several times a day. Apply the cold compress to only one or two joints at a time, and be sure to put a thin towel between the ice pack and the skin to prevent frostbite.

Apple cider vinegar has anti-inflammatory and alkaline-forming properties that help reduce pain and stiffness in the hands from arthritis.

Ginger contains antioxidant and anti-inflammatory properties that help reduce arthritis pain and inflammation. You can add this herb in your foods and also drink ginger tea to derive its benefits.

To make ginger tea:

The combination of honey and cinnamon powder is a good natural way to treat arthritis in hands and help relax stiff musclesdue to their excellent healing properties.Also, honey has antiseptic qualities, while cinnamon has good anti-inflammatory and antioxidant properties.

Epsom salt is good for reducing the stiffness, inflammation and pain associated with arthritis. It is a rich source of magnesium which is important for bone mineralization; most arthritis patientshave demineralized bones. Moreover, magnesium helps decrease nerve pains.

There is a strong connection between olive oil and inflammation caused by arthritis. A special compound known as oleocanthal present in olive oil helps prevent the production of pro-inflammatory COX-1 and COX-2 enzymes.

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Arthritis Help – Remedies to Help Arthritis

October 4th, 2015 10:46 am

Need Arthritis Help? In this informative website you will learn what causes arthritis and then remove it and the symptoms will go away permanently. If you are in a lot of pain visit the arthritis treatment and arthritis remedies pages first to get fast relief. Arthritis is the general term given to a number of painful and debilitating conditions affecting the joints and bones. It is actually made up of two Greek words: athro meaning joints; and itis meaning inflammation. There are over 100 different types of arthritis. Although arthritis is normally associated with people in the baby boomer category and older, it can affect people at any age, even children.

When this happens to children it is called Juvenile Idiopathic Arthritis, although it is much less common than Osteoarthritis or Rheumatoid Arthritis. Gout is another rheumatic condition frequently associated with arthritis as are Psoriatic Arthritis and Ankylosing Spondylitis. Septic Arthritis is an infection combined with arthritis. Bursitis and Spinal Stenosis are inflammatory arthritis and compression type forms of arthritis. Arthritis in Dogs and cats is common as our beloved pets age and eat human unhealthy foods or even lower quality pet foods. There are some forms of arthritis are inherited, but most are not. By and far the most prevalent types of arthritis are Osteoarthritis and Rheumatoid Arthritis.

Wherever our bones meet anatomically, there is also cartilage, an elastic, protective layer that ensures your joints bend smoothly, effortlessly and painlessly. But cartilage cannot do this tremendous job alone. A thin membrane called the synovium provides fluid that lubricates the moving parts of the joint.

When the cartilage wears out due to constant inflammation, an overactive immune system, overuse or just repetitive motion over time, the synovium becomes inflamed; the result is generally a case of either osteoarthritis or rheumatoid arthritis the two most common types of arthritis.

The most common symptoms of arthritis are pain, inflammation and stiffness in particular joints. For Rheumatoid Arthritis, this is most commonly noticed upon arising in the morning. Osteoarthritis is usually noticed later in the day, and some stiffness can be alleviated by simply moving the joint through a smooth range of motion. There may also be some restrictive movement of the affected joints along with some swelling and redness over the joints in many cases. It can become tender to the touch and should be handled with care until you begin a course of treatment. The specific symptoms again will depend upon what type of arthritis youre actually suffering from although the vast majority of types of arthritis all include problems created by the pain, inflammation and swelling of joints.

The exact cause of arthritis is not fully known at this point, however, we are well aware of the factors which may contribute to arthritis: stress, obesity and jobs which require repetitive movements of a particular joint socket. This includes clerical workers, computer programmers, warehouse people, and sports people. For example football players tend to develop arthritis in their knees and ankles as a consequence of injuries sustained to these parts. There is evidence however, that suggests that physically active people who are not injured have a lower risk of arthritis. Some studies have suggested that gout may sometimes be a contributing factor to causing arthritis.

Did you know that Arthritis is actually one of the easiest diseases to cure? Im about to let you in on the secret that your doctor does not want you to know that arthritis sufferers DONT NEED the expensive drugs and treatments they were being sold. Their main concern is staying in business, not keeping you free from arthritis and pain. If you had no arthritis and no pain, you would not need their services and you dont! They would like nothing better than to prescribe medications that will keep you as a customer for life, as they lead to other illnesses that you will need more office visits and more medications to manage (not cure.)

Diet and exercise do play a role in helping to relieve arthritis. You can find out about arthritis exercises and the arthritis diet for more information on using nutrition and movement for arthritis pain relief.

Visit the page on arthritis remedies and youll find the natural supplements that can give you lasting and permanent relief from the most common forms of arthritis. The quickest way to complete relief begins with an understanding of what type of arthritis is affecting you, and then discovering the exact steps that would benefit you the most. A great place to start is the Ultimate Arthritis Cure, which will explain in detail how you get from your particular type of arthritis into having No Arthritis Symptoms and No Arthritis Pain quickly.

The best Arthritis Help is a good education on how to eat and exercise properly and how to use natural supplement timing to reverse the effects of arthritis in your life. You can also get an all in one guide that gives you the knowledge that makes you Arthritis Free For Life.

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Arthritis, Joints Damage – Rheumatoid Arthritis, Psoriatic …

October 4th, 2015 10:46 am

From learning about the importance of exercising regularly to fully understanding your arthritis medications, the information contained in this section is meant to provide you with insights, information and tips that can be used by you to help make living with arthritis a little bit more manageable. Click on the links below to take you to the particular section.

Click on the links below to take you to the particular section.

What is arthritis?

Arthritis is a general term covering more than 100 different conditions.

The term arthritis literally means inflammation of a joint, but is generally used to describe any condition in which there is damage to the cartilage. Inflammation is the body's natural response to injury. The warning signs that inflammation presents are redness, swelling, heat and pain.

The cartilage is a padding that absorbs stress. The proportion of cartilage damage and synovial inflammation varies with the type and stage of arthritis. Usually the pain early on is due to inflammation. In the later stages, when the cartilage is worn away, most of the pain comes from the mechanical friction of raw bones rubbing on each other.

Fibromyalgia, Psoriatic Arthritis

What are the different types of arthritis?

Also called degenerative joint disease, this is the most common type of arthritis, which occurs most often in older people. This disease affects cartilage, the tissue that cushions and protects the ends of bones in a joint. With osteoarthritis, the cartilage starts to wear away over time. In extreme cases, the cartilage can completely wear away, leaving nothing to protect the bones in a joint, causing bone-on-bone contact. Bones may also bulge, or stick out at the end of a joint, called a bone spur.

Osteoarthritis causes joint pain and can limit a person's normal range of motion (the ability to freely move and bend a joint). When severe, the joint may lose all movement, causing a person to become disabled. Disability most often happens when the disease affects the spine, knees, and hips.

This is an autoimmune disease in which the body's immune system (the body's way of fighting infection) attacks healthy joints, tissues, and organs. Occurring most often in women of childbearing age (15-44), this disease inflames the lining (or synovium) of joints. It can cause pain, stiffness, swelling, and loss of function in joints. When severe, rheumatoid arthritis can deform, or change, a joint. For example, the joints in a person's finger can become deformed, causing the finger to bend or curve.

Rheumatoid arthritis affects mostly joints of the hands and feet and tends to be symmetrical. This means the disease affects the same joints on both sides of the body (like both hands or both feet) at the same time and with the same symptoms. No other form of arthritis is symmetrical. About two to three times as many women as men have this disease.

This chronic disorder causes pain throughout the tissues that support and move the bones and joints. Pain, stiffness, and localized tender points occur in the muscles and tendons, particularly those of the neck, spine, shoulders, and hips. Fatigue and sleep disturbances may also occur.

Gout

When a person has gout, they have higher than normal levels of uric acid in the blood. The body makes uric acid from many of the foods we eat. Too much uric acid causes deposits, called uric acid crystals, to form in the fluid and lining of the joints. The result is an extremely painful attack of arthritis. The most common joint gout affects is the big toe. This disease is more common in men than in women.

Infectious arthritis

Arthritis can be caused by an infection, either bacterial or viral, such as Lyme disease. When this disease is caused by bacteria, early treatment with antibiotics can ease symptoms and cure the disease.

Reactive arthritis

This is arthritis that develops after a person has an infection in the urinary tract, bowel, or other organs. People who have this disease often have eye problems, skin rashes, and mouth sores.

Psoriatic arthritis

Some people who have psoriasis, a common skin problem that causes scaling and rashes, also have arthritis. This disease often affects the joints at the ends of the fingers and can cause changes in the fingernails and toenails. Sometimes the spine can also be affected.

Systemic lupus erythematosus

Also called lupus or SLE, this is an autoimmune disease. When a person has an autoimmune disease, the immune system attacks itself, killing healthy cells and tissue, rather than doing its job to protect the body from disease and infection. Lupus can inflame and damage a person's joints, skin, kidneys, lungs, blood vessels, heart, and brain. African American women are three times more likely to get lupus than Caucasian women. It is also more common in Hispanic, Asian, and American Indian women.

Ankylosing spondylitis

This disease most often affects the spine, causing pain and stiffness. It can also cause arthritis in the hips, shoulders, and knees. It affects mostly men in their late teenage and early adult years.

Juvenile rheumatoid arthritis

The most common type of arthritis in children, this disease causes pain, stiffness, swelling, and loss of function in the joints. A young person can also have rashes and fevers with this disease.

Polymyalgia rheumatica

Because this disease involves tendons, muscles, ligaments, and tissues around the joint, symptoms often include pain, aching, and morning stiffness in the shoulders, hips, neck, and lower back. It is sometimes the first sign of giant cell arteritis, a disease of the arteries characterized by inflammation, weakness, weight loss, and fever.

Polymyositis

Causing inflammation and weakness in the muscles, this disease can affect the whole body and cause disability.

Bursitis

This condition involves inflammation of the bursa; small, fluid-filled sacs that help reduce friction between bones and other moving structures in the joints. The inflammation may result from arthritis in the joint or injury or infection of the bursa. Bursitis produces pain and tenderness and may limit the movement of nearby joints.

Tendonitis

Also called tendonitis, this condition refers to inflammation of tendons (tough cords of tissue that connect muscle to bone) caused by overuse, injury, or a rheumatic condition. Tendinitis produces pain and tenderness and may restrict movement of nearby joints.

Rheumatoid Arthritis, Osteoarthritis

What causes osteoarthritis?

Osteoarthritis is caused by the wearing out of the cartilage covering the bone ends in a joint. This may be due to excessive strain over prolonged periods of time, or due to other joint diseases, injury or deformity.

Primary osteoarthritis is commonly associated with aging and general degeneration of joints.

Secondary osteoarthritis is generally the consequence of another disease or condition, such as repeated trauma or surgery to the affected joint, or abnormal joint structures from birth.

Uric acid crystal build-up is the cause of gout and long-term crystal build-up in the joints may cause deformity.

Some people may have congenital abnormalities of the joints - for example, Perthes' disease of the hips-that cause early degeneration and subsequently cause osteoarthritis.

Predisposing factors to osteoarthritis of hip

Some conditions may predispose the hip to osteoarthritis. It tends to affect people as they get older and particularly affects joints that have to take a lot of stresses and strains.

Predisposing factors to osteoarthritis of knee

Abnormalities of knee joint function resulting from fractures of the knee, torn cartilage and torn ligaments can lead to degeneration many years after the injury. The mechanical abnormality leads to excessive wear and tear - just like the out-of-balance tyre that wears out too soon on your car.

What are the symptoms of arthritis?

There are more than 100 different forms of arthritis, symptoms vary according to the form of arthritis. Each form affects the body differently.

Arthritic symptoms generally include swelling and pain or tenderness in one or more joints for more than two weeks, redness or heat in a joint, limitation of motion of a joint, early morning stiffness and skin changes, including rashes.

How can a doctor diagnose arthritis?

Doctors diagnose arthritis with a medical history, physical exam and x-rays of the hip. There is no blood test for osteoarthritis.

What you can do?

What your doctor can do for you?

There is no cure for arthritis, so beware of 'miracle cures'. Your doctor may prescribe anti-inflammatory medicine. They may recommend occupational therapy or physiotherapy, which includes exercises and heat treatment. In severe cases, surgery may be suggested, such as a hip or knee replacement. The type of surgery will depend on your age and severity of the disease. In the elderly with severe arthritis, joint replacement can give good results.

Treatment Options

Treatment of osteoarthritis focuses on decreasing pain and improving joint movement, and may include:

Does exercise really help those who have arthritis?

Exercise is very important because it increases lubrication of the joints and strengthens the surrounding muscles, putting less stress on joints. Exercise in heated swimming pools-hydrotherapy-can bring enormous relief from pain and stiffness. Also studies have shown that exercise helps people with arthritis by reducing joint pain and stiffness and increasing flexibility, muscle strength and energy. It also helps with weight reduction and offers an improved sense of well-being.

Can special diets treat arthritis?

These are the sorts of questions that people with arthritis often ask, and they're valid questions. Some questions (Can what you eat cure your arthritis?) have simple answers (No). Some questions (Are there foods that can cause your arthritis to 'flare' or go into remission?) aren't so straightforward (Perhaps...).

Most of what you need to know about diet and nutrition is common sense; healthy eating is pretty much the same for anyone, whether you have arthritis or not. But there are exceptions.

Summary

From learning about the importance of exercising regularly to fully understanding your arthritis medications, the information contained in this section is meant to provide you with insights, information and tips that can be used by you to help make living with arthritis a little bit more manageable.

For people with arthritis, learning to make it part of your life can be difficult. But learning as much as you can about your particular type of arthritis and actively working with your arthritis treatment team are two very effective ways of regaining control over your life. There is plenty of information, some specific to arthritis and some not, that can be very helpful to someone facing the challenges associated with having a chronic or lifelong disease.

Our suggestion is - don't let arthritis beat you. Take control. How? Arm yourself with as much information as possible. Learn from the experiences of others in similar circumstances. What we're presenting here is a virtual toolbox of tips for living well with arthritis. Some may work for you one day and not the other. That's why we've tried to cover several topics. There are plenty of tools or tips here. Use them or refer to them when you need them. Call upon them when you require help.

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Kentucky: Cabinet for Health and Family Services – Diabetes

October 3rd, 2015 5:41 pm

Contact Us:

275 E. Main St.Frankfort, KY 40621 (502) 564-7996

The Diabetes Prevention and Control Programis a population-based, public health initiative consisting of a network of state, regionaland local health professionals whose mission is to reduce new cases of diabetes as well as the sickness, disability and death associated with diabetes and its complications.

Go to Diabetes Resources Directory. This site allows searches for diabetes resources such as classes, support groups and coalitions by county and surrounding area. In addition, this site contains direct links to sites that list diabetes specialists and educators by location.

The National Diabetes Prevention Program (DPP) led by CDC incorporates lifestyle changes which are proven to prevent type 2 diabetes.

Organizations offering the DPP program in Kentucky:

The National Diabetes Education Program (NDEP) is a joint program of the Centers for Disease Control and Prevention, the National Institutes of Health and more than 200 partners working together to improve the treatment and outcomes of diabetes in individuals, families, communities and health care systems.

The NDEP uses public awareness and educational tools to inform people with diabetes about the importance of knowing their blood glucose values, reaching their blood glucose goals and keeping their blood glucose under control.The NDEP also provides messages and tools to help those at risk for type 2 diabetesmake the lifestyle changes that may prevent or delay the development of diabetes.

The NDEP also has diabetes education resources and tools designed especially for health care professionals, business professionals engaged in planning and conduction business health strategies and school personnel. Whether in clinical practice, classroom, or workplace, managing diabetes effectively is complex and requires a team approach. Click on the pictures below to take advantage of NDEP resources and tools based on the latest scientific research.

If you area person with diabetes,it is very important to be prepared for any disaster.The valuable information below can help you survive in the event of a disaster.Please print and save any of this information.

Kentucky Diabetes Prevention and Control Program Disasters and Diabetes Curriculum

Being Prepared for a Disaster When You Have Diabetes

Additional Resources and References

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Kentucky: Cabinet for Health and Family Services - Diabetes

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Diabetes Center | Jefferson University Hospitals | Serving …

October 3rd, 2015 5:41 pm

The Jefferson Diabetes Center in Philadelphia consists of a clinical diabetes program catering to patients with Type 1 and Type 2 diabetes (outpatient and inpatient), a research center performing state-of-the-art clinical trials and a weight management center. Our Center provides guidance and management of prediabetes, diabetes and its complications.

The Jefferson Diabetes Center offers multidisciplinary care coordinated closely with your referring physician and provides the latest in treatment and technology for patients with diabetes.

The Center is supervised by specialists within the Division of Endocrinology, Diabetes and Metabolic Diseases who consult with ophthalmologists, nephrologists, podiatrists, neurologists, cardiologists, vascular surgeons and obstetrician/gynecologists as needed. You will receive instruction in diabetic self-care and diet management from certified diabetes nurse educators and registered nutritionists with a special expertise in diabetes.

The comprehensive treatment offered to patients with diabetes includes convenient access to essential services including:

Patients have access to leading-edge treatment for even the most complicated cases. With a comprehensive, one-stop location for diabetes care, patients are better able to manage their symptoms from diabetes and possibly avoid potential complications from uncontrolled blood glucose levels.

Our diabetes education classes are unique in the area. We offer various types of education targeting patients with Type 2 diabetes (basic and advanced classes), Type 1 diabetes (intensive insulin management) and patients with metabolic syndrome/borderline diabetes/obesity. For patients with Type 1 diabetes (and some patients with Type 2 diabetes), we provide an excellent courseon insulin pumps and continuous glucose sensors, using the latest technology.

In addition, patients interested in significant weight loss can join our Comprehensive Weight Management Program, which consists of a medically supervised liquid fast paired with lifestyle education and ongoing personalized support.

Patients interested in participating in volunteer research can enroll in one of our many clinical trials. We have a very active Diabetes Research Center with extensive experience in both federally funded and pharmaceutical industrysponsored clinical trials. Most of our trials are related to diabetes and obesity. Volunteers contribute to the advancement and future of health care.

The treatment of acute and chronic illnesses improves every year because of advancing science and research. Advances in medical treatments are made possible through clinical studies. A clinical study (clinical trial) is the scientific evaluation of an experimental drug or device. By taking part in these studies, volunteers may gain access to the latest in medical care that is only available through this process.

Academic Title: Professor

Division Director, Endocrinology

Director, Diabetes Center

Director, Comprehensive Weight Management Program

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Diabetes Basics – What is Diabetes? – Lifeclinic

October 3rd, 2015 5:41 pm

Diabetes Basics: What is Diabetes? | Who's at Risk? | Symptoms | Diagnosis | Complications | Other Health Issues

Diabetes is a chronic disease that affects as many as 16 million Americans. For reasons that are not yet clear, diabetes is increasing in our population to the point where public health authorities are calling diabetes an "epidemic" that requires urgent attention.

Of the 16 million people with diabetes, about one-third of them don't even know they have it. Every year, 800,000 additional cases are diagnosed. It affects over six percent of the population now, and it is projected that nearly nine percent of all Americans will have diabetes by the year 2025. Health care costs for diabetes are estimated to be nearly $100 billion per year in the US.

People with diabetes are unable to use the glucose in their food for energy. The glucose accumulates in the bloodstream, where it can damage the heart, kidneys, eyes and nerves. Left untreated, diabetes can develop devastating complications. It is one of the leading causes of death and disability in the United States.

However, the good news is that with proper care, people with diabetes can lead normal, satisfying lives. Much of this care is "self-managed," meaning that if you have this condition, you must take day-to-day responsibility for your own care.

Most important to managing the disease is to know as much about it as you can. The first thing to know is what kind of diabetes you have. There are three types:

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Tissue Engineering and Regenerative Medicine | National …

October 1st, 2015 2:47 pm

Cells are the building blocks of tissue, and tissues are the basic unit of function in the body. Generally, groups of cells make and secrete their own support structures, called extra-cellular matrix. This matrix, or scaffold, does more than just support the cells; it also acts as a relay station for various signaling molecules. Thus, cells receive messages from many sources that become available from the local environment. Each signal can start a chain of responses that determine what happens to the cell. By understanding how individual cells respond to signals, interact with their environment, and organize into tissues and organisms, researchers have been able to manipulate these processes to mend damaged tissues or even create new ones.

The process often begins with building a scaffold from a wide set of possible sources, from proteins to plastics. Once scaffolds are created, cells with or without a cocktail of growth factors can be introduced. If the environment is right, a tissue develops. In some cases, the cells, scaffolds, and growth factors are all mixed together at once, allowing the tissue to self-assemble.

Another method to create new tissue uses an existing scaffold. The cells of a donor organ are stripped and the remaining collagen scaffold is used to grow new tissue. This process has been used to bioengineer heart, liver, lung, and kidney tissue. This approach holds great promise for using scaffolding from human tissue discarded during surgery and combining it with a patients own cells to make customized organs that would not be rejected by the immune system.

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Regenerative Medicine – Transplant Center – Mayo Clinic

October 1st, 2015 2:47 pm

At Mayo Clinic, an integrated team, including stem cell biologists, bioengineers, doctors and scientists, work together and study regenerative medicine. The goal of the team is to treat diseases using novel therapies, such as stem cell therapy and bioengineering. Doctors in transplant medicine and transplant surgery have pioneered the study of regenerative medicine during the past five decades, and doctors continue to study new innovations in transplant medicine and surgery.

In stem cell therapy, or regenerative medicine, researchers study how stem cells may be used to replace, repair, reprogram or renew your diseased cells. Stem cells are able to grow and develop into many different types of cells in your body. Stem cell therapy may use adult cells that have been genetically reprogrammed in the laboratory (induced pluripotent stem cells), your own adult stem cells that have been reprogrammed or cells developed from an embryo (embryonic stem cells).

Researchers also study and test how reprogrammed stem cells may be turned into specialized cells that can repair or regenerate cells in your heart, blood, nerves and other parts of your body. These stem cells have the potential to treat many conditions. Stem cells also may be studied to understand how other conditions occur, to develop and test new medications, and for other research.

Researchers across Mayo Clinic, with coordination through the Center for Regenerative Medicine, are discovering, translating and applying stem cell therapy as a potential treatment for cardiovascular diseases, diabetes, degenerative joint conditions, brain and nervous system (neurological) conditions, such as Parkinson's disease, and many other conditions. For example, researchers are studying the possibility of using stem cell therapy to repair or regenerate injured heart tissue to treat many types of cardiovascular diseases, from adult acquired disorders to congenital diseases. Read about regenerative medicine research for hypoplastic left heart syndrome.

Cardiovascular diseases, neurological conditions and diabetes have been extensively studied in stem cell therapy research. They've been studied because the stem cells affected in these conditions have been the same cell types that have been generated in the laboratory from various types of stem cells. Thus, translating stem cell therapy to a potential treatment for people with these conditions may be a realistic goal for the future of transplant medicine and surgery.

Researchers conduct ongoing studies in stem cell therapy. However, research and development of stem cell therapy is unpredictable and depends on many factors, including regulatory guidelines, funding sources and recent successes in stem cell therapy. Mayo Clinic researchers aim to expand research and development of stem cell therapy in the future, while keeping the safety of patients as their primary concern.

Mayo Clinic offers stem cell transplant (bone marrow transplant) for people who've had leukemia, lymphoma or other conditions that have been treated with chemotherapy.

Mayo Clinic currently offers a specialty consult service for regenerative medicine within the Transplant Center, the first consult service established in the United States to provide guidance for patients and families regarding stem cell-based protocols. This consult service provides medical evaluations for people with many conditions who have questions about the potential use of stem cell therapy. The staff provides guidance to determine whether stem cell clinical trials are appropriate for these individuals. Regenerative medicine staff may be consulted if a doctor or patient has asked about the potential use of stem cell therapies for many conditions, including degenerative or congenital diseases of the heart, liver, pancreas or lungs.

People sometimes have misconceptions about the use and applications of stem cell therapies. This consult service provides people with educational guidance and appropriate referrals to research studies and clinical trials in stem cell therapies for the heart, liver, pancreas and other organs. Also, the consult service supports ongoing regenerative medicine research activities within Mayo Clinic, from basic science to clinical protocols.

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Genetic Engineering – BiologyMad

September 30th, 2015 2:45 pm

Genetic Engineering

Genetic engineering, also known as recombinant DNA technology, means altering the genes in a living organism to produce a Genetically Modified Organism (GMO) with a new genotype. Various kinds of genetic modification are possible: inserting a foreign gene from one species into another, forming a transgenic organism; altering an existing gene so that its product is changed; or changing gene expression so that it is translated more often or not at all.

Genetic engineering is a very young discipline, and is only possible due to the development of techniques from the 1960s onwards. Watson and Crick have made these techniques possible from our greater understanding of DNA and how it functions following the discovery of its structure in 1953. Although the final goal of genetic engineering is usually the expression of a gene in a host, in fact most of the techniques and time in genetic engineering are spent isolating a gene and then cloning it. This table lists the techniques that we shall look at in detail.

1

cDNA

To make a DNA copy of mRNA

2

To cut DNA at specific points, making small fragments

3

DNA Ligase

To join DNA fragments together

4

Vectors

To carry DNA into cells and ensure replication

5

Plasmids

Common kind of vector

6

Gene Transfer

To deliver a gene to a living cells

7

Genetic Markers

To identify cells that have been transformed

8

To make exact copies of bacterial colonies on an agar plate

9

PCR

To amplify very small samples of DNA

10

DNA probes

To identify and label a piece of DNA containing a certain sequence

11

Shotgun *

To find a particular gene in a whole genome

12

Antisense genes *

To stop the expression of a gene in a cell

13

Gene Synthesis

To make a gene from scratch

14

Electrophoresis

To separate fragments of DNA

* Additional information that is not directly included in AS Biology. However it can help to consolidate other techniques.

Complementary DNA (cDNA) is DNA made from mRNA. This makes use of the enzyme reverse transcriptase, which does the reverse of transcription: it synthesises DNA from an RNA template. It is produced naturally by a group of viruses called the retroviruses (which include HIV), and it helps them to invade cells. In genetic engineering reverse transcriptase is used to make an artificial gene of cDNA as shown in this diagram.

Complementary DNA has helped to solve different problems in genetic engineering:

It makes genes much easier to find. There are some 70 000 genes in the human genome, and finding one gene out of this many is a very difficult (though not impossible) task. However a given cell only expresses a few genes, so only makes a few different kinds of mRNA molecule. For example the b cells of the pancreas make insulin, so make lots of mRNA molecules coding for insulin. This mRNA can be isolated from these cells and used to make cDNA of the insulin gene.

These are enzymes that cut DNA at specific sites. They are properly called restriction endonucleases because they cut the bonds in the middle of the polynucleotide chain. Some restriction enzymes cut straight across both chains, forming blunt ends, but most enzymes make a staggered cut in the two strands, forming sticky ends.

The cut ends are sticky because they have short stretches of single-stranded DNA with complementary sequences. These sticky ends will stick (or anneal) to another piece of DNA by complementary base pairing, but only if they have both been cut with the same restriction enzyme. Restriction enzymes are highly specific, and will only cut DNA at specific base sequences, 4-8 base pairs long, called recognition sequences.

Restriction enzymes are produced naturally by bacteria as a defence against viruses (they restrict viral growth), but they are enormously useful in genetic engineering for cutting DNA at precise places ("molecular scissors"). Short lengths of DNA cut out by restriction enzymes are called restriction fragments. There are thousands of different restriction enzymes known, with over a hundred different recognition sequences. Restriction enzymes are named after the bacteria species they came from, so EcoR1 is from E. coli strain R, and HindIII is from Haemophilis influenzae.

This enzyme repairs broken DNA by joining two nucleotides in a DNA strand. It is commonly used in genetic engineering to do the reverse of a restriction enzyme, i.e. to join together complementary restriction fragments.

The sticky ends allow two complementary restriction fragments to anneal, but only by weak hydrogen bonds, which can quite easily be broken, say by gentle heating. The backbone is still incomplete.

DNA ligase completes the DNA backbone by forming covalent bonds. Restriction enzymes and DNA ligase can therefore be used together to join lengths of DNA from different sources.

In biology a vector is something that carries things between species. For example the mosquito is a disease vector because it carries the malaria parasite into humans. In genetic engineering a vector is a length of DNA that carries the gene we want into a host cell. A vector is needed because a length of DNA containing a gene on its own wont actually do anything inside a host cell. Since it is not part of the cells normal genome it wont be replicated when the cell divides, it wont be expressed, and in fact it will probably be broken down pretty quickly. A vector gets round these problems by having these properties:

It is big enough to hold the gene we want (plus a few others), but not too big.

It is circular (or more accurately a closed loop), so that it is less likely to be broken down (particularly in prokaryotic cells where DNA is always circular).

It contains control sequences, such as a replication origin and a transcription promoter, so that the gene will be replicated, expressed, or incorporated into the cells normal genome.

It contain marker genes, so that cells containing the vector can be identified.

Many different vectors have been made for different purposes in genetic engineering by modifying naturally-occurring DNA molecules, and these are now available off the shelf. For example a cloning vector contains sequences that cause the gene to be copied (perhaps many times) inside a cell, but not expressed. An expression vector contains sequences causing the gene to be expressed inside a cell, preferably in response to an external stimulus, such as a particular chemical in the medium. Different kinds of vector are also available for different lengths of DNA insert:

Type of vector

Max length of DNA insert

10 kbp

Virus or phage

30 kbp

Bacterial Artificial Chromosome (BAC)

500 kbp

Plasmids are by far the most common kind of vector, so we shall look at how they are used in some detail. Plasmids are short circular bits of DNA found naturally in bacterial cells. A typical plasmid contains 3-5 genes and there are usually around 10 copies of a plasmid in a bacterial cell. Plasmids are copied separately from the main bacterial DNA when the cell divides, so the plasmid genes are passed on to all daughter cells. They are also used naturally for exchange of genes between bacterial cells (the nearest they get to sex), so bacterial cells will readily take up a plasmid. Because they are so small, they are easy to handle in a test tube, and foreign genes can quite easily be incorporated into them using restriction enzymes and DNA ligase.

One of the most common plasmids used is the R-plasmid (or pBR322). This plasmid contains a replication origin, several recognition sequences for different restriction enzymes (with names like PstI and EcoRI), and two marker genes, which confer resistance to different antibiotics (ampicillin and tetracycline).

The diagram below shows how DNA fragments can be incorporated into a plasmid using restriction and ligase enzymes. The restriction enzyme used here (PstI) cuts the plasmid in the middle of one of the markergenes (well see why this is useful later). The foreign DNA anneals with the plasmid and is joined covalently by DNA ligase to form a hybrid vector (in other words a mixture or hybrid of bacterial and foreign DNA). Several other products are also formed: some plasmids will simply re-anneal with themselves to re-form the original plasmid, and some DNA fragments will join together to form chains or circles. Theses different products cannot easily be separated, but it doesnt matter, as the marker genes can be used later to identify the correct hybrid vector.

Vectors containing the genes we want must be incorporated into living cells so that they can be replicated or expressed. The cells receiving the vector are called host cells, and once they have successfully incorporated the vector they are said to be transformed. Vectors are large molecules which do not readily cross cell membranes, so the membranes must be made permeable in some way. There are different ways of doing this depending on the type of host cell.

Heat Shock. Cells are incubated with the vector in a solution containing calcium ions at 0C. The temperature is then suddenly raised to about 40C. This heat shock causes some of the cells to take up the vector, though no one knows why. This works well for bacterial and animal cells.

Electroporation. Cells are subjected to a high-voltage pulse, which temporarily disrupts the membrane and allows the vector to enter the cell. This is the most efficient method of delivering genes to bacterial cells.

Viruses. The vector is first incorporated into a virus, which is then used to infect cells, carrying the foreign gene along with its own genetic material. Since viruses rely on getting their DNA into host cells for their survival they have evolved many successful methods, and so are an obvious choice for gene delivery. The virus must first be genetically engineered to make it safe, so that it cant reproduce itself or make toxins. Three viruses are commonly used:

1. Bacteriophages (or phages) are viruses that infect bacteria. They are a very effective way of delivering large genes into bacteria cells in culture.

2. Adenoviruses are human viruses that causes respiratory diseases including the common cold. Their genetic material is double-stranded DNA, and they are ideal for delivering genes to living patients in gene therapy. Their DNA is not incorporated into the hosts chromosomes, so it is not replicated, but their genes are expressed.

The adenovirus is genetically altered so that its coat proteins are not synthesised, so new virus particles cannot be assembled and the host cell is not killed.

3. Retroviruses are a group of human viruses that include HIV. They are enclosed in a lipid membrane and their genetic material is double-stranded RNA. On infection this RNA is copied to DNA and the DNA is incorporated into the hosts chromosome. This means that the foreign genes are replicated into every daughter cell.

After a certain time, the dormant DNA is switched on, and the genes are expressed in all the host cells.

Plant Tumours. This method has been used successfully to transform plant cells, which are perhaps the hardest to do. The gene is first inserted into the Ti plasmid of the soil bacterium Agrobacterium tumefaciens, and then plants are infected with the bacterium. The bacterium inserts the Ti plasmid into the plant cells' chromosomal DNA and causes a "crown gall" tumour. These tumour cells can be cultured in the laboratory and whole new plants grown from them by micropropagation. Every cell of these plants contains the foreign gene.

Gene Gun. This extraordinary technique fires microscopic gold particles coated with the foreign DNA at the cells using a compressed air gun. It is designed to overcome the problem of the strong cell wall in plant tissue, since the particles can penetrate the cell wall and the cell and nuclear membranes, and deliver the DNA to the nucleus, where it is sometimes expressed.

Micro-Injection. A cell is held on a pipette under a microscope and the foreign DNA is injected directly into the nucleus using an incredibly fine micro-pipette. This method is used where there are only a very few cells available, such as fertilised animal egg cells. In the rare successful cases the fertilised egg is implanted into the uterus of a surrogate mother and it will develop into a normal animal, with the DNA incorporated into the chromosomes of every cell.

Liposomes. Vectors can be encased in liposomes, which are small membrane vesicles (see module 1). The liposomes fuse with the cell membrane (and sometimes the nuclear membrane too), delivering the DNA into the cell. This works for many types of cell, but is particularly useful for delivering genes to cell in vivo (such as in gene therapy).

These are needed to identify cells that have successfully taken up a vector and so become transformed. With most of the techniques above less than 1% of the cells actually take up the vector, so a marker is needed to distinguish these cells from all the others. Well look at how to do this with bacterial host cells, as thats the most common technique.

A common marker, used in the R-plasmid, is a gene for resistance to an antibiotic such as tetracycline. Bacterial cells taking up this plasmid can make this gene product and so are resistant to this antibiotic. So if the cells are grown on a medium containing tetracycline all the normal untransformed cells, together with cells that have taken up DNA thats not in a plasmid (99%) will die. Only the 1% transformed cells will survive, and these can then be grown and cloned on another plate.

Replica plating is a simple technique for making an exact copy of an agar plate. A pad of sterile cloth the same size as the plate is pressed on the surface of an agar plate with bacteria growing on it. Some cells from each colony will stick to the cloth. If the cloth is then pressed onto a new agar plate, some cells will be deposited and colonies will grow in exactly the same positions on the new plate. This technique has a number of uses, but the most common use in genetic engineering is to help solve another problem in identifying transformed cells.

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Arthritic Dogs Healed With New Stem Cell Therapy – ABC News

September 29th, 2015 11:46 am

A couple of years ago, Brad Perry's dogs started having joint problems. Cowboy, the golden retriever, developed a severe case of arthritis, while Mr. Jones, the mutt, tore the ligaments in both of his knees during some overenthusiastic play.

"It was so sad. They wouldn't even come to the door to greet me they were in so much pain. It just broke my heart," recalled Perry, a tractor-trailer driver from Alexandria, Ky.

Perry gave the dogs all sorts of medications, but nothing worked, and he knew such medications could result in kidney and liver damage. The dogs' suffering became so great, Perry considered putting the pets down. But late last year he heard about a veterinarian in his area who performed stem cell therapy on dogs to regenerate and repair their joints and figured it was worth a try.

Cowboy underwent the procedure first. Mr. Jones followed a few months later. Perry said that within 10 days of receiving treatment the dogs were like puppies again, chasing his kids, running around in the park and swimming in the lake.

The treatment Perry's dogs received was developed by MediVet America of Lexington, Ky., one of several companies that sell equipment and training to veterinary clinics around the world. MediVet has more than a thousand clinics. Participating vets have performed more than 10,000 stem cell procedures about 7,000 of them in the past 12 months.

An operation like the one Cowboy and Mr. Jones underwent takes several hours. To start, the vet harvests a few tablespoons of fat cells from the pet's abdomen or shoulder, then spins the cells in a centrifuge to separate out the stem cells that are naturally present in fat. Next, the cells are mixed with special enzymes to "digest" any residual fat and connective tissue, and are then "activated" by mixing them with "plasma rich platelets" extracted from the animal's blood cells. The mixture is stimulated under a LED light for 20 minutes or so to further concentrate the stem cells. Finally, the newly awakened cells are injected back into the damaged joint.

Jeremy Delk, MediVet's chief executive officer, said that the therapy works because stem cells are the only cells in the body that have the ability to transform themselves into other types of specialized cells -- such as cartilage -- making them a potent tool for repairing damaged and deteriorating joints. There are 50 to 1,000 times more stem cells in the fat than bone marrow, a source that was more consistently used in animal and human -- stem cell therapy until the fat method started becoming more popular.

"As we age, humans and animals alike, our stem cells are starting to die off so we have fewer. What we are able to do with these techniques is isolate the cells in very large numbers, wake them up and put them back into the area that needs help," he explained.

While still largely unavailable to their owners, stem cell therapy from fat cells has been offered to our furry friends for several years. With fewer regulatory hoops to jump through in veterinary medicine and no contentious religious debates, experimental procedures are often tested and perfected on animals decades before they're green-lighted for use on humans.

One of the things veterinarians and owners alike praise about the procedure is it can be completed in one day, and all at the vet's office. Stem cells can also be banked for future injection so the animal does not have to endure extraction again.

John Sector, the owner of Shelby St. Veterinarian Hospital in Florence, who performed the surgery on Cowboy and Mr. Jones, had high praise for the therapy.

"This is potentially a game changer. We're seeing incredible results in the joints. We also see some unexpected improvements in other things, like skin conditions," he said.

Stem cell therapy is not just for pets who curl up on couches or ride in the backseat either. Delk said horses, donkeys, zebras and lions are also regular stem cell patients. He and his team recently traveled to the Middle East to perform the therapy on some prized racing camels.

However, stem cell remedies, even for animals, are still considered experimental. Shila Nordone, the chief scientific officer at the AKC Canine Health Foundation, a nonprofit group that funds health research for dogs, said that its use for joint regenerative purposes is exciting, but that the lower regulatory bar in animal medicine is both good and bad.

"It's good because we can do things sooner for our patients without 10 years of expensive clinical trials, but bad because we are still in the process of establishing best practices to ensure the procedures are the safest and most effective possible," she said.

Studies funded by the Health Foundation and others have been promising. One study of more than 150 dogs found improvements in joint stiffness, mobility and other joint health indicators in nearly 95 percent of arthritic cases. In some patients, improvements were seen in as little as a week while others took up to 90 days and required multiple injections.

The cost of a single procedure is $1800-$3,000, depending on the area of the country, the species of animal and severity of joint damage. Even those with pet insurance can expect to pay out of pocket.

Owners like Perry believe it is worth every penny.

"They are completely different dogs. It absolutely changed their lives," he said of Cowboy and Mr. Jones. "It changed mine too -- I got my dogs back."

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Types of Gene Therapy Treatment | MD Anderson Cancer Center

September 29th, 2015 11:43 am

Much of today's cancer research is devoted to finding missing or defective genes that cause cancer or increase an individual's risk for certain types of cancer. Gene research at MDAnderson has resulted in many important discoveries. We identified the mutated multiple advanced cancers gene (MMAC1) involved in some common cancers. We also performed the first successful correction of a defective tumor suppressor gene (p53) in human lung cancer. Current gene therapies are experimental, and many are still tested only on animals. There are some clinical trials involving a very small number of human subjects.

The potential benefits of gene therapy are two-fold:

The focus of most gene therapy research is the replacement of a missing or defective gene with a functional, healthy copy, which is delivered to target cells with a "vector." Viruses are commonly used as vectors because of their ability to penetrate a cells DNA. These vector viruses are inactivated so they cannot reproduce and cause disease. Gene transfer therapy can be done outside the body (ex vivo) by extracting bone marrow or blood from the patient and growing the cells in a laboratory. The corrected copy of the gene is introduced and allowed to penetrate the cells DNA before being injected back into the body. Gene transfers can also be done directly inside the patients body (in vivo).

Other therapies include:

Gene therapy is a complicated area of research, and many questions remain unanswered. Some cancers are caused by more than one gene, and some vectors, if used incorrectly, can actually cause cancer or other diseases. Replacing faulty genes with working copies also brings up ethical issues that must be addressed before these therapies can be accepted for preventing cancer. Talk to your cancer specialist about the implications of gene therapy.

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Home – Palm Beach Diabetes

September 29th, 2015 11:43 am

I am a 76 year old woman who has had Diabetes for the past twenty years. Recently my blood sugar counts went completely out of whack and I became frightened. Remembering how I gave my mother daily insulin injections, I did not want this procedure to take over my life. Well, I have to express my thanks to Palm Beach Diabetes & Endocrine Specialists for their help. I thought I knew it all on how to keep myself under control. Oh was I wrong. First the Doctor reevaluated and readjusted my medication. Then I attended two very informative classes where Diabetes was explained in great detail. The exchange of thoughts with the other attendees gave me great insight of myself and what I had been doing up to then. This was followed by two one-on-one sessions with a very knowledgeable nutritionist who answered all my special questions. Then came the best learning tool ever. I attended a Supermarket Tour with a counselor from your office. I learned to properly read food labels, to understand the size of portion control, and one can still eat. Publix also gave out some very interesting literature on varied food items and products. In the past twenty years, I have attended many courses, schools, workshops, and sessions privately and community based. None ever taught me or helped me as this integrated program. My husband was able to attend all these sessions with me so helps me greatly now. I have lost some weight, as I should. The greatest point is that my medication is being reevaluated. Again, I thank you all for making my life livable.

Anon

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Resveratrol By RevGenetics Resveratrol Benefits, Anti …

September 28th, 2015 1:43 pm

TA-65 And Other Items:

Our RevGenetics X500 resveratrol capsules and our Nitro250 micronized resveratrol capsules harnesses the power of the red wine molecule that is becoming well known in the medical field for its potential to help aging, combat cancer, viral infections, and the effects of diabetes, as well as its anti-aging potential. The red wine molecule is considered for it's potential and possible help combating age-related illnesses such as Alzheimers and arthritis.

Each resveratrol capsule contains the highest purity Resveratrol (99% Pure) on the market and is tested to be some of the safest, simply because we take it ourselves.

Safety First: By testing every batch of Resveratrol, we have actually prevented a bad batch that unscrupulous Chinese vendors tried to hand off to the US market. We know first hand that unsafe material is sold to manufacturers and can even pass the scrutiny of Consumer Labs, since they test test about once yearly. Therefore we simply test every batch for our customers, to prevent unsafe material from ending up in our own products.

Have a question on Resveratrol Supplements? Feel free to use our support desk to send us a question on our products. Link to our support desk

New Studies About Resveratrol Supplements

RevGenetics Micronized Trans-Resveratrol powder offers TrueMicronized particles with a particle size of 1.5 microns, and is absorbed up to 220% compared to regular Resveratrol supplements that average between 149 to 224 microns*. When emulsified, the absorption can increase and go beyond 500%.

Try our bulk powder or our nitrogen protected Licaps capsule in our Nitro250 with up to 2 to 5 times the bioavailability.

We are the only provider of Licaps with TrueMicronized particles that measures an average of 1.5 microns.

These Licaps are protected from light, heat, and oxygen with a nitrogen bubble in each individual capsule.

The Nitro250 provides 250mg of micronized resveratrol.

Micronized Resveratrol *Based on absorption study in USPTO document 20060292099. Licaps and Licaps Design are trademarks used under license.

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Second Sight Argus II Eye Prosthesis Brings Central Vision …

September 28th, 2015 1:41 pm

July 22nd, 2015 Editors Ophthalmology

Second Sight, effectivelythe first company to bring rudimentary sight back to blind patients with certain underlying eye conditions (retinitis pigmentosa and outer retinal degeneration), is now proudly reporting that a man with dry age-related macular degeneration (AMD) who has lost central vision has been outfitted with the firms Argus II prosthetic. This is part of a study that will involve more patients and will assess whether the system, which includes a wireless implant and a special set of glasses, essentially replaces the work of the diseased natural photoreceptors and stimulates the remaining healthy retinal cells. The original video signal is gathered from a camera built into a pair of glasses, which is then converted by a wearable computer and sent wireless to the implant.

Heres more about the trial, including video of the patient seeing using the Argus IIsystem:

Product page: Argus II Retinal Prosthesis System

Source: Second Sight

Editors

At Medgadget, we report on the latest medical technology news, interview leaders in the field, and file dispatches from medical events around the world.

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Gene Therapy – A Revolution in Progress: Human Genetics …

September 27th, 2015 2:42 am

Gene therapy attempts to treat genetic diseases at the molecular level by correcting what is wrong with defective genes. Clinical research into gene therapys safety and effectiveness has just begun. No one knows if gene therapy will work, or for what diseases. If gene therapy is successful, it could work by preventing a protein from doing something that causes harm, restoring the normal function of a protein, giving proteins new functions, or enhancing the existing functions of proteins. How Do You Do It? Gene therapy relies on finding a dependable delivery system to carry the correct gene to the affected cells. The gene must be delivered inside the target cells and work properly without causing adverse effects. Delivering genes that will work correctly for the long term is the greatest challenge of gene therapy.

Human ex vivo Gene Therapy

1986

1989

1993

Present

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Gene Therapy - A Revolution in Progress: Human Genetics ...

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