StemCell Therapy

Stem Cells in Focus is an ISSCR topic in which a series of webcasts is organized allowing the public to discuss Stem Cell topics with leaders in the field.

Yesterday STELLAR member Melissa Little dicussed her topic during a webcast session on:Exploring Organoids: Growing a Kidney in a Dish.

Below is an interview with Melissa conducted byMaya Chaddah leading up to the webcast.

There was great excitement in 2013 when Australian scientist, Prof. Melissa Little, at The University of Queenslands Institute for Molecular Bioscience in Brisbane, Australia saw tiny buds of tissue growing in a dish that looked like embryonic kidneys. Originally a cancer geneticist, she had spent years studying the genes and pathways that lead to the formation of Wilms tumor, a kidney cancer found in children. As the connections between abnormal kidney formation during development and kidney dysfunction in children became apparent, she began exploring new ways to help individuals with kidney disease.

In the 15 years since Prof. Little started focusing on kidney development, renal disease and repair, the rates of chronic kidney disease have skyrocketed globally, due in large part to conditions like diabetes, hypertension (high blood pressure), glomerulonephritis (immune-mediated disease) and cardiovascular disease. Although the adult kidney can repair some damage for example, after a night of excessive alcohol, a period of dehydration, rapid blood loss, or exposure to chronic toxins it cannot grow new nephrons, which are vital to its function, after we are born. So chronic kidney damage takes its toll and ultimately leaves individuals on dialysis or awaiting kidney transplants, which are in very short supply.

The kidney is a very complex organ, comprised of 250,000 to 2 million nephrons that filter the blood (about 5 cups/minute), resorb nutrients and excrete waste. Each nephron is shaped like the head of a wrench leading into a long convoluted tube that bends and winds. Blood is filtered at the head of the wrench and different points along the tube take back what the body needs ions, amino acids and water. The tube then dumps what the body doesnt want into a large pipe called the collecting duct, which funnels the waste to the bladder for excretion. Any condition that repeatedly affects the ability of the nephrons to filter the blood can lead to a build-up of kidney damage over time.

Prof. Littles team was keen to understand kidney development in humans. Because the adult human kidney cannot make new nephrons, they attempted to replicate the process by which nephrons develop in the human embryo, using cultured cells grown in the laboratory. This involved identifying the conditions under which embryonic stem cells derived from the earliest unspecialized cells in an embryo can be coaxed to make mesoderm, the layer of cells in the early embryo with the potential to make kidney cells. From there, they developed a very tight, quality controlled method for reproducibly making nephron progenitors, the cells which make nephrons, as well as early nephrons and collecting duct cells.

What Prof. Littles team finds amazing is how exactly these types of cells, the nephrons and their progenitors and collecting duct cells, self-assemble into three dimensional structures outside the body, in a totally artificial lab environment. She likens the mystery to when animals are born and immediately just know how to stand up and go to their mothers. The kidney organoids her team can grow right now are only tiny buds of tissue, much smaller than normal kidneys and less complicated, but clearly with the same kinds of cells found in an embryo making a kidney. The next steps are to keep pushing the kidney organoids down the developmental pathway that ends with fully functional organs, and then to investigate whether the nephrons could do their job if given a blood supply.

More:
STELLAR - Stem Cells in Kidney Disease - Stem Cell based ...

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Chemistry Conversions

by Stephen Z. Fadem, M.D., FACP

The primary focus of The Nephron Information Center is to support the generation and dissemination of valid health information relevant to the kidney community as well as to the public. How can we meet your needs as we filter and recycle useful information? Your comments are welcome in Guestbook

DISCLAIMER

Note: This information does not constitute medical advice, and is for information and education purposes only. We cannot answer questions nor give any advice through e-mail. Please consult your physician for specific treatment recommendations. The information obtained through this service, and the information which you receive through the Internet is only for general guideline purposes, and is not an ultimate source of information, nor something which you should rely on as a sole source for your medical care. All medical and therapeutic decisions must come from your health care provider. The authors, editors, producers, sponsors, and contributors shall have no liability, obligation or responsibility to any person or entity for any loss, damage, adverse consequence alleged to have happened directly or indirectly as a consequence of this material.

about the Author, Stephen Z. Fadem, M.D., FACP

1996 - 2005 Stephen Z Fadem, M.D., FACP all rights reserved

HOW MANY HOURS SHOULD AN ONLINE CME PROGRAM BE? TOUCHCALC: The Mergener Formula

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Kidney Resource Page

BCH Division of Genetics and Genomics Seminar

Generating Cartilage from Human Pluripotent Stem Cells: A Developmental Approach.

Special Seminar

How Neurons Talk to the Blood: Sensory Regulation of Hematopoiesis in the Drosophila Model

Genetics Seminar Series

Neural Reprogramming of Germline Cells and Trans-Generational Memory in Drosophila

BCH Division of Genetics and Genomics Seminar

Genetics Seminar Series - Focused Seminars

Reflecting the breadth of the field itself, the Department of Genetics at Harvard Medical School houses a faculty working on diverse problems, using a variety of approaches and model organisms, unified in their focus on the genome as an organizing principle for understanding biological phenomena. Genetics is not perceived simply as a subject, but rather as a way of viewing and approaching biological phenomena.

While the range of current efforts can best be appreciated by reading the research interests of individual faculty, the scope of the work conducted in the Department includes (but is by no means limited to) human genetics of both single gene disorders and complex traits, development of genomic technology, cancer biology, developmental biology, signal transduction, cell biological problems, stem cell biology, computational genetics, immunology, synthetic biology, epigenetics, evolutionary biology and plant biology.

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Home | HMS Department of Genetics

Gene therapy carries the promise of cures for many diseases and for types of medical treatment that didn't seem possible until recently. With its potential to eliminate and prevent hereditary diseases such as cystic fibrosis and hemophilia and its use as a possible cure for heart disease, AIDS, and cancer, gene therapy is a potential medical miracle-worker.

But what about gene therapy for children? There's a fair amount of risk involved, so thus far only seriously ill kids or those with illnesses that can't be cured by standard medical treatments have been involved in clinical trials using gene therapy.

As those studies continue, gene therapy may soon offer hope for children with serious illnesses that don't respond to conventional therapies.

Our genes help make us unique. Inherited from our parents, they go far in determining our physical traits like eye color and the color and texture of our hair. They also determine things like whether babies will be male or female, the amount of oxygen blood can carry, and the likelihood of getting certain diseases.

Genes are composed of strands of a molecule called DNA and are located in single file within the chromosomes. The genetic message is encoded by the building blocks of the DNA, which are called nucleotides. Approximately 3 billion pairs of nucleotides are in the chromosomes of a human cell, and each person's genetic makeup has a unique sequence of nucleotides. This is mainly what makes us different from one another.

Scientists believe that every human has about 25,000 genes per cell. A mutation, or change, in any one of these genes can result in a disease, physical disability, or shortened life span. These mutations can be passed from one generation to another, inherited just like a mother's curly hair or a father's brown eyes. Mutations also can occur spontaneously in some cases, without having been passed on by a parent. With gene therapy, the treatment or elimination of inherited diseases or physical conditions due to these mutations could become a reality.

Gene therapy involves the manipulation of genes to fight or prevent diseases. Put simply, it introduces a "good" gene into a person who has a disease caused by a "bad" gene.

The two forms of gene therapy are:

Currently, gene therapy is done only through clinical trials, which often take years to complete. After new drugs or procedures are tested in laboratories, clinical trials are conducted with human patients under strictly controlled circumstances. Such trials usually last 2 to 4 years and go through several phases of research. In the United States, the U.S. Food and Drug Administration (FDA) must then approve the new therapy for the marketplace, which can take another 2 years.

The most active research being done in gene therapy for kids has been for genetic disorders (like cystic fibrosis). Other gene therapy trials involve children with severe immunodeficiencies, such as adenosine deaminase (ADA) deficiency (a rare genetic disease that makes kids prone to serious infection), sickle cell anemia, thalassemia, hemophilia, and those with familial hypercholesterolemia (extremely high levels of serum cholesterol).

Read this article:
Gene Therapy and Children - KidsHealth

knowledge center home diabetes what is diabetes?

Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia).

Fast facts on diabetes

Here are some key points about diabetes. More detail and supporting information is in the main article.

There are three types of diabetes:

The body does not produce insulin. Some people may refer to this type as insulin-dependent diabetes, juvenile diabetes, or early-onset diabetes. People usually develop type 1 diabetes before their 40th year, often in early adulthood or teenage years.

Type 1 diabetes is nowhere near as common as type 2 diabetes. Approximately 10% of all diabetes cases are type 1.

Patients with type 1 diabetes will need to take insulin injections for the rest of their life. They must also ensure proper blood-glucose levels by carrying out regular blood tests and following a special diet.

Between 2001 and 2009, the prevalence of type 1 diabetes among the under 20s in the USA rose 23%, according to SEARCH for Diabetes in Youth data issued by the CDC (Centers for Disease Control and Prevention). (Link to article)

The body does not produce enough insulin for proper function, or the cells in the body do not react to insulin (insulin resistance).

Read the rest here:
Diabetes: Causes, Symptoms and Treatments

Welcome to the internet site of the Glaucoma Service Foundation to Prevent Blindness.We believe the best patient care is only possible when patients actively participate in their care and are as informed as possible about glaucoma. This site, voted one of the top five glaucoma websites in the world, provides a wealth of information as well as links to other resources.

This site provides access to unique chat sessions hosted by Glaucoma Service physicians. This chat was honored at the 2004 Annual Meeting of the American Academy of Ophthalmology as the premiere virtual glaucoma chat support group in the world, which personalizes the educational outreach of the Service to an unprecedented degree. The chat support group is a cornerstone of the Services e-Medicine program, which includes tele-consultation, tele-informatics, and research into the practicality of tele-screening for glaucoma.

The Glaucoma Service Foundation was founded in 1979 by world renowned glaucoma specialist George L. Spaeth, MD and his late wife Ann to support glaucoma education, research and community outreach.

Special thanks to the Robison D. Harley Fund for Glaucoma Education and Research, the lead sponsor for the Annual CARES Conference.

Wills Eye is consistently ranked as one of America's best ophthalmology centers by U.S. News & World Report.

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Glaucoma Service Foundation to Prevent Blindness

Onchocerciasis ( or ), also known as river blindness and Robles disease, is a disease caused by infection with the parasitic worm Onchocerca volvulus.[1] Symptoms include severe itching, bumps under the skin, and blindness.[1] It is the second most common cause of blindness due to infection, after trachoma.[2]

The parasite worm is spread by the bites of a black fly of the Simulium type.[1] Usually many bites are required before infection occurs.[3] These flies live near rivers therefore the name of the disease.[2] Once inside a person the worms create larvae that make their way out to the skin.[1] Here they can infect the next black fly that bites the person.[1] There are a number of ways to make the diagnosis including: placing a biopsy of the skin in normal saline and watching for the larva to come out, looking in the eye for larvae, and looking within the bumps under the skin for adult worms.[4]

A vaccine against the disease does not exist.[1] Prevention is by avoiding being bitten by flies.[5] This may include the use of insect repellent and proper clothing.[5] Other efforts include those to decrease the fly population by spraying insecticides.[1] Efforts to eradicate the disease by treating entire groups of people twice a year is ongoing in a number of areas of the world.[1] Treatment of those infected is with the medication ivermectin every six to twelve months.[1][6] This treatment kills the larva but not the adult worms.[7] The medication doxycycline, which kills an associated bacterium called Wolbachia, appears to weaken the worms and is recommended by some as well.[7] Removal of the lumps under the skin by surgery may also be done.[6]

About 17 to 25 million people are infected with river blindness, with approximately 0.8 million having some amount of loss of vision.[3][7] Most infections occur in sub-Saharan Africa, although cases have also been reported in Yemen and isolated areas of Central and South America.[1] In 1915, the physician Rodolfo Robles first linked the worm to eye disease.[8] It is listed by the World Health Organization as a neglected tropical disease.[9]

Adult worms remain in subcutaneous nodules, limiting access to the host's immune system.[citation needed] Microfilariae, in contrast, are able to induce intense inflammatory responses, especially upon their death. Wolbachia species have been found to be endosymbionts of O. volvulus adults and microfilariae, and are thought to be the driving force behind most of O. volvulus morbidity. Dying microfilariae have been recently discovered to release Wolbachia surface protein that activates TLR2 and TLR4, triggering innate immune responses and producing the inflammation and its associated morbidity.[10] The severity of illness is directly proportional to the number of infected microfilariae and the power of the resultant inflammatory response.[citation needed]

Skin involvement typically consists of intense itching, swelling, and inflammation.[11] A grading system has been developed to categorize the degree of skin involvement:[12][13][verification needed]

Ocular involvement provides the common name associated with onchocerciasis, river blindness, and may involve any part of the eye from conjunctiva and cornea to uvea and posterior segment, including the retina and optic nerve.[11] The microfilariae migrate to the surface of the cornea. Punctate keratitis occurs in the infected area. This clears up as the inflammation subsides. However, if the infection is chronic, sclerosing keratitis can occur, making the affected area become opaque. Over time, the entire cornea may become opaque, thus leading to blindness. Some evidence suggests the effect on the cornea is caused by an immune response to bacteria present in the worms.[citation needed] The skin is itchy, with severe rashes permanently damaging patches of skin.

The Mazzotti reaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of onchocerciasis with the medication diethylcarbamazine(DEC). Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis.

The phenomenon is so common when DEC is used that this drug is the basis of a skin patch test used to confirm that diagnosis. The drug patch is placed on the skin, and if the patient is infected with O. volvulus microfilaria, localized pruritus and urticaria are seen at the application site.[14]

This is an unusual form of epidemic epilepsy associated with onchocerciasis.[15] This syndrome was first described in Tanzania by Louise Jilek-Aall, a Norwegian psychiatric doctor in Tanzanian practice, during the 1960s. It occurs most commonly in Uganda and South Sudan.

See the article here:
Onchocerciasis - Wikipedia, the free encyclopedia

Chronic Pain develops slowly and is persistent and long-lasting. Acute and Chronic Injuries Acute injuries are sudden, sharp, traumatic injuries that occur immediately (or within hours) and cause pain (possibly severe pain). Most often acute injuries result from some sort of impact or trauma such as a fall, sprain, or collision and it's pretty obvious what caused the injury.

Acute injuries also cause common signs and symptoms of injury such as pain, tenderness, redness, skin that is warm to the touch, swelling and inflammation. If you have swelling, you have an acute injury.

Chronic injuries, on the other hand, can be subtle and slow to develop. They sometimes come and go, and may cause dull pain or soreness. They are often the result of overuse, but sometimes develop when an acute injury is not properly treated and doesn't heal.

Cold Therapy with Ice Cold therapy with ice is the best immediate treatment for acute injuries because it reduces swelling and pain. Ice is a vaso-constrictor (it causes the blood vessels to narrow) and it limits internal bleeding at the injury site. There is controversy as to whether continued application of ice results in a sudden vasodilation of the blood vessels (the hunting response) and if so, at what time this response begins and how often a cycle of constriction and dilation occurs.

To ice an injury, wrap ice in a thin towel and place it on the affected area for 10 minutes at a time. Allow the skin temperature to return to normal before icing a second or third time. You can ice an acute injury several times a day for up to three days.

Cold therapy is also helpful in treating some overuse injuries or chronic pain in athletes. An athlete who has chronic knee pain that increases after running may want to ice the injured area after each run to reduce or prevent inflammation.

The best way to ice an injury is with a high quality ice pack that conforms to the body part being iced. Examples include ColdOne Cold Therapy Wraps and SnowPack Cold Therapy products. You can also get good results from a bag of frozen peas, an ice massage with water frozen in a paper cup (peel the cup down as the ice melts) or a bag of ice.

Read more about how to safely use ice on injuries.

Heat Therapy Heat is generally used for chronic injuries or injuries that have no inflammation or swelling. Sore, stiff, nagging muscle or joint pain is ideal for the use of heat therapy. Athletes with chronic pain or injuries may use heat therapy before exercise to increase the elasticity of joint connective tissues and to stimulate blood flow. Heat can also help relax tight muscles or muscle spasms. Don't apply heat after exercise. After a workout, ice is the better choice on a chronic injury.

Because heat increases circulation and raises skin temperature, you should not apply heat to acute injuries or injuries that show signs of inflammation. Safely apply heat to an injury 15 to 20 minutes at a time and use enough layers between your skin and the heating source to prevent burns.

Go here to read the rest:
Ice or Heat a Sports Injury? - Sports Medicine

Ranked third in the nation among colleges of veterinary medicine by U.S. News & World Report, NC States College of Veterinary Medicine is a driving force in veterinary innovation. From our leadership in understanding and defining the interconnections between animal and human health, to groundbreaking research in areas like equine health, and our commitment to training the next generation of veterinary health professionals, we are dedicated to advancing animal and human health from the cellular level through entire ecosystems.

Learn more about what we do

The following article by Tracey Peake, reprinted from The Abstract: NC States research blog,concerns research by neurobiologist Troy Ghashghaei of the Department of Molecular Biomedical Sciences in NC States College of Veterinary Medicine.

A common protein, when produced by specialized barrier cells in the brain, could help protect the brain from damage due to aging. This protein MARCKS may act as both a bouncer and a housekeeping service, by helping clear away proteins and keeping the cell barrier intact, and its absence in these cells weakens their ability to serve as a barrier and transport system for cerebrospinal fluid (CSF) in the brain.

Your brain doesnt just sit in your skull like play-doh in its plastic case. Its surrounded and cushioned by CSF, a clear, colorless fluid produced in the brain that circulates nutrients and chemicals taken from blood throughout the brain. CSF also removes waste products and sends them back out to the bloodstream for disposal.

Like blood, CSF only circulates through certain channels. Ependymal cells are the specialized cells that serve as both the barrier to keep the CSF running through its channels and as the transport system that moves various molecules between the brain and the CSF.

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NC State College of Veterinary Medicine

Life-Saving Stem Cells - Discover, Learn, ShareNearly everyone inside and outside of the medical and scientific community agrees that stem cell research represents one of the most exciting and promising frontiers for treating people with a myriad of diseases and conditions. Stem cell research and treatments represent perhaps mankind's greatest opportunity to fulfill that ancient call to "heal the sick," relieve suffering and improve the quality of life for untold millions of people.

This website provides scientific facts and concise information for those of us who are not scientists, researchers or medical professionals. You will learn answers toquestions like ..."Who is benefitting from stem cell research and therapies today?" and "What types of stem cells are working?" In addition, basic questions such as"What is a stem cell?""Why do we need stem cell research?" are answered.

The video patient profiles featured on this site emphasize ADULT stem cell advances with the goal of informing and the hope of inspiring you to take action. These real-life stories represent a small sampling of people and the many diseases and conditions now being helped by adult stem cells naturally found in the human body. Stem Cell Research Facts illustrates how current adult treatments and therapies directly impact the lives of patients and their families today - as opposed to debating themerits of other types of stem cell research.

We invite you to discover, learn and share the incredible possibilites of stem cell research. We welcome your feedback and encourage you to return for the latest developments in the world of stem cell research. Thank you!

Read more here:
Adult Stem Cells - Therapies and Treatments

Medical travel for unproven stem-cell-based therapies is commonly referred to as stem cell tourism. Clinics worldwide over-promise the benefits of their so-called treatments and grossly downplay or ignore the risks. Such unproven therapy is without scientific rationale. Neither the efficacy of the treatments, nor the lack of serious side effects has been shown in animal models. This 'magic cure by stem cells' approach must be condemned under all circumstances. If there is no chance of improvement in the patients condition, the 'therapy' is both unethical and scientifically and clinically unacceptable. It will not help the patient; the risks for adverse effects may be high; and it will not contribute to the development of clinically-established stem cell therapies. Even if the administration of stem cells is associated with negligible or minor risks, clinical application remains unjustified on a compassionate basis: the patient's expectations will not be met and they are very likely to suffer emotionally as a result. The solution must be to encourage governments to tighten regulations and to better educate patient-consumers.

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Stem cell tourism: The risks of unproven therapies ...

Is there a maximum biological limit to the human life span of somewhere around 120 years?

Could we live much longer, given the right conditions?

Answers to these and other fundamental questions about aging may now be within reach.

IS THERE AN AGE LIMIT?

One hundred and twenty years, as far as we know, is the longest that anyone has ever lived. A man in Japan, Shirechiyo Izumi, reached the age of 120 years, 237 days in 1986, according to documents that most experts think are authentic. He died after developing pneumonia.

Long lives always make us wonder: What is the secret? Does it lie in the genes? Is it where people live or the way they live -- something they do or do not do? Eat or do not eat? Most of the scientists who study aging, gerontologists, say the secret probably lies in all of the above -- heredity, environment, and lifestyle.

But gerontologists also ask other and more difficult questions. For example, if the 120-year-old had not finally succumbed to illness, could he have lived on and on? Or was he approaching some built-in, biological limit? Is there a maximum human life span beyond which we cannot live no matter how optimal our environment or favorable our genes?

Whether or not there is such a limit, what happens as we age? What are the dynamics of this process and how do they make life spans short, average, or long? Once we understand these dynamics, could they be used to extend everyone's life span to 120 or even, as some scientists speculate, to much greater ages?

And finally for all of us, the most important question: How can insights into longevity be used to fight the diseases and disabilities associated with old age to make sure this period of life is healthy, active, and independent?

In Search of the Secrets of Aging describes what we know so far about the answers to these questions and what we want to know. It gives an overview of research on aging and longevity, showing the major puzzle pieces already in place and, to the extent possible, the shapes of those that are missing.

Originally posted here:
Secrets of Aging, Long Life, longevity Genes

Welcome! If you want to lose weight, gain muscle, increase energy levels or just generally look and feel healthier you've come to the right place.

Here's where to start:

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A time-honored and research-tested way to extend an animals lifespan is to restrict its caloric intake. Studies repeatedly confirm that if, say, a lab mouse normally gets two full bowls of lab chow a day, limiting that mouse to one and a half bowls of lab chow a day will make that mouse live longer than the mouse eating the full two bowls.Cool, cool, a longer life is great and all, but what about the downsides of straight calorie restriction, aside from willfully restricting your food intake, ignoring hunger pangs, relegating yourself to feeling discontent with meals, and counting calories and macronutrients obsessively? Are there any others? Sure:

Loss of muscle mass. Humans undergoing calorie restriction often suffer loss of lean muscle mass and strength, all pretty objectively negative effects (unless you really go for the gaunt Christian Bale in The Machinist look and use a super-strong bionic exoskeleton for all your physical tasks).

Loss of bone mineral density. Humans who calorie restrict in studies also show signs of lower bone mineral density when compared to humans who lose weight from exercise,particularly in the hip and spine the two areas most susceptible to fall-related bone breaks. I wrote about this study some time ago here.

Oh, and theres the fact that the act of restricting ones calories can be mind-numbing, miserable, and difficult for a great many people, especially if its a lifelong pursuit. (Unless, of course, you eat according to the Primal Blueprint and are fat-adapted. It can make CR not only tolerable, but a cinch because we become so good at living off stored body fat. We dont suffer from sugar lows when we skip meals the way most people who fast do, but I digress.) Thats kind of a biggie.

What about fasting? In previous installments of this series, Ive explained how fasting can sometimes be described as a short cut to the benefits of calorie restriction, an easier (and even more effective) path to the same destination. Studies on fasting/calorie restriction and cancer find that fasting is more effective in a shorter amount of time (weeks or months versus mere days). Does the same hold true for longevity? Can fasting also extend lifespan without making us look like a calorie-restricted monkey?

1945 marks the first real study (PDF) of the effects of intermittent fasting on lifespan in animals. Beginning at day 42 of their lives, rats were either fasted one day in four, one day in three, or every other day. All fasted rats, save for the females who were fasted one day in four, lived longer than control rats on a normal schedule. Although females outlived males in general (like always), fasting had the greatest effect in males. Male rats did best on every other day fasting; female rats did best on one day in three fasting. Fasted rats weighed less than control rats, so they likely also ate less, even though feeding days were ad libitum.

In a 1982 study, mice fed every other day lived 82% longer than mice fed ad libitum every day. No word on calorie intake.

More here:
How Fasting Increases Lifespan | Mark's Daily Apple

Located in the heart of Perth, the leading health professionals at Chiropractic Care & Longevity Center are dedicated to helping you achieve your wellness objectives -- combining skill and expertise that spans the entire chiropractic wellness spectrum.Dr. Kathy Wickens is committed to bringing you better health and a better way of life by teaching and practicing the true principles of chiropractic wellness care.

Patients seeking treatment at Chiropractic Care & Longevity Center with Dr. Kathy Wickens are assured of receiving only the finest quality care through the use of modern chiropractic equipment and technology. Dr. Kathy Wickens and the staff have a genuine concern for your well-being!

If you are new to our website, please feel free to discover and learn about chiropractic wellness. If you are interested in starting your journey towards wellness please subscribe to our award winning newsletter. If you are already a newsletter subscriber, please explore the member wellness section of our website for wellness articles, resources, and health facts---specifically targeted by Dr. Kathy Wickens to your wellness needs and interests.

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Personalized Regenerative Medicine

Stem Cells & Stem Cell Therapies

Making sure the bases are covered As a persons own bone marrow stem cells play an important role in helping heal damaged organs andtissues in many diseases.Dr. Steenblock tests for things that interfere with stem cell mobilization and/or their vitality and activity: Heavy metals such as mercury, lead, cadmium, arsenic, etc: With adults, A DMPS* View Article

When a doctor sees a patient for the first time he will ask for copies of medical records as part of gathering information and data that, in combination with taking a medical history and doing relevant exams and tests, helps him arrive at a diagnosis (or confirm previously made ones) and formulate a medical care View Article

Augmenting natures own repair & restoration mechanism When diseasesets in and begins to progress the sufferers bodytries to repair the damage by activating stem cells. Unfortunately, these stem cells are not always up to the job of repair and regeneration. The chemical signals produced by the ailing bodythen attracts circulating bone marrow stem cells. However, View Article

In his decades of private practice, Dr Steenblock has established himself as a pioneer in many fields of medicine. From stroke care andacute brain trauma to regenerative and cell-based medicine in the treatment of ALS, Cerebral Palsy and other chronic and degenerative diseases, what has separated Dr Steenblock from his peers is his unique and View Article

Putting it all together Once a patients diagnosis is confirmed, modified or even overturned and the results of all tests ordered are in, Dr. Steenblock formulates a treatment plan. The therapeutic regimen he introduces is personalized to help insure the patient gets optimal results and has his greatest shot at making significant clinical improvements. If View Article

NEW COMPREHENSIVE STEM CELL PROGRAM FOR STROKE SURVIVORS During the past twenty years Dr. David Steenblock has treated over 2000 stroke patients using daily hyperbaric oxygen and other leading edge treatments. As-a-result he has learned a great deal about what it takes to help stroke patients get the most improvement possible, even 10 years or View Article

Here are patients speaking about the experiences with stem cells and stroke and being treated by Dr Steenblock. In his decades of private practice, Dr Steenblock has established himself as a pioneer in many fields of medicine. From stroke care andacute brain trauma to regenerative and cell-based medicine in the treatment of ALS, Cerebral View Article

Dale Hartley suffered a stroke ten and a half years ago. Dale had heard about Dr. Steenblocks program on the radio. He was as thrilled then as today that Dr. Steenblock had something more to offer than conventional medicine. He and his wife Audrey came to Dr. Steenblocks clinic to undergo the stroke program. When View Article

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Dr David Steenblock - Adult Stem Cells & Stem Cell Treatments

TREATMENT WITH Fat Stem Cell Therapy

Diabetes Type II Treatment Avg. Rating: 4 out of 5 from 67 votes.

Diabetes Type II is perhaps the most common form of diabetes and affects millions of Americans. We believe that 8.5% of the American population suffers from Type 2 Diabetes. The condition develops with age, diet and has links to being passed on by parents. In Diabetes Type II, either the body does not produce enough insulin or the cells ignore the insulin. "Insulin is necessary for the body to be able to use glucose for energy. When you eat food, the body breaks down all of the sugars and starches into glucose, which is the basic fuel for the cells in the body. Insulin takes the sugar from the blood into the cells." This quote comes from the American Diabetes Association website.

Expensive drugs and strict diets are needed to control Diabetes Type II, until now. Today we have Fat Stem Cell Therapy. Experts know that fat stem cell therapy has shown the reversal of Type 2 Diabetes with blood sugar, triglycerides and hemoglobin A1c returning to normal within 6 weeks.

A detailed explanation of our procedure for treating Diabetes Type II with autologous adipose enriched Stem Cell Therapy is available on our procedure page. Activated Stem Cells are returned back into the patient using an intravenous drip. The entire process takes about 5-6 hours to complete.

Just a few hours after the patient receives the treatment, the stem cells will be hard at work repairing the clients body. Normal levels of all benchmarks used to monitor Type 2 Diabetes should be reached within 6 weeks, yet we have seen dramatic changes within 2-4 weeks.

What is really important to note is that if a slight lifestyle and diet change is not made the condition can return just as quickly. Our qualified staff will provide the client with all the information they need to make the small corrections to their diet and lifestyle.

Is The Procedure Painful? No, the procedure is painless and takes about 3.5 hours to harvest and activate the stem cells and about 3 hours to intravenously drip them back into your body. There will be some pain after the local abdominal anesthetic has worn off, but we curb that pain by keeping the client immobilized for up to 48 hours. Our Aftercare program really accelerates results by providing in-depth information to the patient about Diabetes Type II management post treatment.

Does The Type 2 Diabetes Procedure Really Work? YES! It has been clinically tested. The main thing to remember here is that if you do not make a diet and small life-style change, your condition will return.

How Much Does Type 2 Diabetes Therapy Cost? We package the Medical Procedure with a Recovery Program.

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Diabetes Type II Treatment With Fat Stem Cell Therapy

ABSTRACT

Objectives:Background for use of autologous adipose tissue as a source of adult progenitor (stem) cells for use in Prolotherapy. Present a means of lipoaspiration to harvest adipose-derived mesenchymal stromal cells (AD-MSC) and the stromal vascular fraction (SVF) for use in Prolotherapy and regenerative medical applications by non-plastic surgeons.

Design:Explain the patented super luer-lok and microcannulas for use with the Tulip Medical closed syringe system. A sequential explanation and equipment selection for minimally traumatic lipoaspiration in small volumes is presented.

Results:Thousands of autologous fat grafts (AFG) have proven safe and efficacious for lipoaspiration techniques for large and small structural fat grafting procedures. Addition of platelet-rich plasma (PRP) to AFG has been used in several thousand cases of HD ultrasonic-guided injection Prolotherapy for musculoskeletal purposes in the past 4 years with excellent clinical outcomes.

Conclusions:Use of Tulip closed syringe lipoaspiration system with microcannulas offers a safe and effective means of harvesting small volumes of non-manipulated adipose tissues and its accompanying progenitor cells within the SVF. It offers a simple and effective means to gather undifferentiated cells for use in Prolotherapy and regenerative medical applications. Syringe and microcannulas offer a compact system and practical protocol for non-plastic surgical practitioners.

Journal of Prolotherapy.2011;3(3):680-688.

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For many years, cosmetic-plastic surgeons have recognized the value of low pressure lipoaspiration for successful transplantation of adipose tissue for structural augmentation. In the introductory years (1980-1990) of liposuction techniques, autologous fat grafting (AFG) was considered unpredictable. Once bioengineers discovered the mechanisms by which lipoaspiration worked, the closed syringe system for gentle harvesting and transplantation was developed and patented. Early belief that effective lipoaspiration was directly related to force of vacuum was replaced by understanding, that, introduction of fluid into the fat layers permitted the fat cells and stroma to enter into a suspension. This suspension was easily extracted through use of closed syringes, and provided adipose tissues with reduced damage and improved grafting results.1

As the importance of tumescent fluid distribution was appreciated, more value was placed in extensive pre-tunneling (moving cannula without applying vacuum). This better distributed local solution and enhanced the ability to mobilize the adipose tissues into a suspension, which yielded more successful and predictable AFG. During the late 1990s, surgeons began to include utilization of platelet-rich plasma (PRP) to further enhance the successes and acceptance of the graft tissues, in both large and small volume transfers.2

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Autologous Fat Grafts as Mesenchymal Stromal Stem Cell ...

ProgeniDerm Anti-Senescence Skin Stem Cell Serum encourages new epidermal cell growth while protecting and prolonging the cell life of existing skin cells. Wrinkle depth is reduced, hyperpigmentation lightened, and collagen/elastin fibers become thicker and stronger. The ratio of older skin cells to younger skin cells is reversed. Skin looks visibly younger.

Elegantly formulated with fruit-derived Malus Domestica Fruit Stem Cell Extract, ProgeniDerm protects against chromosomal damage that signals skin cells to undergo apoptosis (cell death). Often this signal is sent prematurely due to free radical damage caused by UV light, smoke, stress, etc. With protection against this damage, existing skin cells live longer and more new cells are created.

The Malus Domestica Fruit Stem Cell Extract in ProgeniDerm restores aging skin stem cells regenerative properties. In-vitro and in-vivo testing showed that this new extract:

The ultimate result: skin that regains its ability to repair itself and regenerate new skin cells within two weeks. Substantially greater numbers of new epithelial cells are formed. Enzymes are released that protect cells from damage that shorten the skin cell life cycle. The addition of chondrus crispus (red seaweed/algae extract) and palmitoyl oligopeptide in a hyaluronic acid base combine to make our ProgeniDerm Anti-Senescence Skin Stem Cell serum a powerful new tool against premature aging.

Note: Epidermal skin stem cell DNA/chromosomal protection is the newest, most exciting direction for anti-aging products currently. Cellular Skin Rx is proud to be able to provide a serum containing this cutting-edge, naturally-derived extract to our customers. Now that peptides are firmly established as helpful to the skin for relaxing, firming, and reducing inflammation, using naturally-derived fruit stem cell extracts to prevent damage at the most basic cellular level is taking skin care to a whole new realm. You will see more and more of this approach to maintaining a younger complexion moving forward -with Cellular Skin Rx proudly providing you with products that incorporate these new Active Ingredients That Work.

After applying antioxidant serum of your choice, apply twice daily including eye area.

Combining with antioxidant serums such as C+ Firming serum or CSRx Antioxidant Complex yields best results.

Two weeks to gorgeous skin routine: Each morning use CSRx Antioxidant Defense Complex then C+ Firming serum, follow with ProgeniDerm Anti-Senescence Skin Stem Cell Serum, then any wrinkle-relaxers/firming products/moisturizers/sunscreen you regularly use. Each night use Age-Limit Advanced Refinishing serum or Ultra-Gentle Enzyme Surface Peel, then apply ProgeniDerm again. In just two weeks, you will see a visible difference in your skin tone, color, and texture.

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ProgeniDerm Anti-Senescence Skin Stem Cell Serum ...

Approximately 11 million Americans aged 12 years and older could improve their vision through proper refractive correction. More than 3.3 million Americans aged 40 years and older are either legally blind (having best-corrected visual acuity of 6/60 or worse (=20/200) in the better-seeing eye) or are with low vision (having best-corrected visual acuity less than 6/12 (<20/40) in the better-seeing eye, excluding those who were categorized as being blind). The leading causes of blindness and low vision in the United States are primarily age-related eye diseases such as age-related macular degeneration, cataract, diabetic retinopathy, and glaucoma. Other common eye disorders include amblyopia and strabismus.

For a basic demonstration of the eyes anatomy, watch the Anatomy video.

Refractive errors are the most frequent eye problems in the United States. Refractive errors include myopia (near-sightedness), hyperopia (farsightedness), astigmatism (distorted vision at all distances), and presbyopia that occurs between age 4050 years (loss of the ability to focus up close, inability to read letters of the phone book, need to hold newspaper farther away to see clearly) can be corrected by eyeglasses, contact lenses, or in some cases surgery. Recent studies conducted by the National Eye Institute showed that proper refractive correction could improve vision among 11 million Americans aged 12 years and older.

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Macular degeneration, often called age-related macular degeneration (AMD), is an eye disorder associated with aging and results in damaging sharp and central vision. Central vision is needed for seeing objects clearly and for common daily tasks such as reading and driving. AMD affects the macula, the central part the retina that allows the eye to see fine details. There are two forms of AMDwet and dry.

Wet AMD is when abnormal blood vessel behind the retina start to grow under the macula, ultimately leading to blood and fluid leakage. Bleeding, leaking, and scarring from these blood vessels cause damage and lead to rapid central vision loss. An early symptom of wet AMD is that straight lines appear wavy.

Dry AMD is when the macula thins overtime as part of aging process, gradually blurring central vision. The dry form is more common and accounts for 7090% of cases of AMD and it progresses more slowly than the wet form. Over time, as less of the macula functions, central vision is gradually lost in the affected eye. Dry AMD generally affects both eyes. One of the most common early signs of dry AMD is drusen.

Drusen are tiny yellow or white deposits under the retina. They often are found in people aged 60 years and older. The presence of small drusen is normal and does not cause vision loss. However, the presence of large and more numerous drusen raises the risk of developing advanced dry AMD or wet AMD.

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CDC - About Vision Health - Common Eye Disorders - Vision ...

The eye is a slightly asymmetrical globe, about an inch in diameter. The front part of the eye (the part you see in the mirror) includes:

The iris (the pigmented part) The cornea (a clear dome over the iris) The pupil (the black circular opening in the iris that lets light in) The sclera (the white part) The conjunctiva (a thin layer of tissue covering the front of the eye, except the cornea)

Just behind the iris and pupil lies the lens, which helps to focus light on the back of the eye. Most of the eye is filled with a clear gel called the vitreous. Light projects through the pupil and the lens to the back of the eye. The inside lining of the eye is covered by special light-sensing cells that are collectively called the retina. The retina converts light into electrical impulses. Behind the eye, the optic nerve carries these impulses to the brain. The macula is a small extra-sensitive area within the retina that gives central vision. It is located in the center of the retina and contains the fovea, a small depression or pit at the center of the macula that gives the clearest vision.

Eye color is created by the amount and type of pigment in the iris. Multiple genes inherited from each parent determine a persons eye color.

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Eye Health Center - WebMD