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Stem Cell Therapy for Diabetes Cure Hyperglycemia

August 4th, 2016 9:40 am

Stem Cell Therapyfor Diabetics

Diabetes Mellitus (DM) is condition characterized by a common element, hyperglycemia, which contributes to the development of macro-vascular , microvascular and neuropathic complications; making it one of the major causes of mortality in developed or developing societies. It affects a great number of people throughout the world. Diabetes is a degenerative disease that causes a person to have higher than normal blood sugar as a result of the body not producing enough insulin (Type 1) or sometimes because the cells wont respond to the insulin being produced (Type 2). This high blood sugar state produces the symptoms known as polyuria or frequent urination,polyphagia increased hunger and polydipsia increased thirst.

The 3 Primary types of Diabetes Mellitus in humans is:

Other known types of diabetes mellitus DM include cystic fibrosis-related diabetes, steroid induced diabetes (high doses of glucocorticoids),congenital diabetes (genetic defects of insulin secretion), and some types of monogenic diabetes.

Some major contributing factors of diabetes type 1 and 2 are high blood pressure or hyperglycemia or low blood sugar hypoglycemic.Recent clinical trials for treatment of Diabetes using Stem cells have some that some oral diabetic medications may help contribute to premature heart failure. Men, Women and children diagnosed with diabetes type 1 or 2 should seek treatment for hypoglycemia or hyperglycemia as these symptoms are very dangerous and can lead to more problems if let untreated.

Our Peripheral Blood Stem Cell Diabetes Treatment(PBSC ) therapy for Diabetes Type II does just that. Stem Cell Treatments for Diabetes isAutologous (stem cells from your own body) and is also Painless (Unlike Bone Marrow Stem Cell Treatments while maintaining effectiveness) and without the use of any pharmaceuticals using patients own circulating Stem Cells from peripheral blood or adipose MSC stem cells.

Diabetes Cause & Stem Cell Diabetes Treatment

TheCell Transplantsfor Diabeticsuses enriched PBSC or Cord Blood treatment plan fights diabetes on the bodies cellular level to help eliminate hyperglycemia and all its associated complications. Recent trials have also suggested that Stem Cells can also reduces low blood sugar hypoglycemic events that if left untreated can result in severe debilitation or even death. Our treatmentprotocol in Bangkok will require use of your own naturally produced stem cells in the bloodstream. A process called leukapheresis or apheresis is used to obtain PBSCs (Peripheral Blood Stem Cells) for transplantation. For about 2 or 4 days before the apheresis, the patient may be given medication to help increase the number of circulating stem cells in the bloodstream. During apheresis, blood is removed through the large vein in the patients arms or via a CVC central venous catheter which is a flexible tube inserted in neck, chest, or groin veins. The blood is collected through the proprietary stem cell collection machine. The machine counts and separates the CD34+ MSC and Progenitor Stem cells that are used in ourtreatment protocol. Apheresis and cell collection can take 3 to 5 hours. The CD34 Positive MSC and Progenitor stem cells are then isolated, and expanded using Platelet Rich Plasma PRP and growth factors and then finally re-injected back into the patient to complete the Diabetes Treatment using stem cells in Thailand.

Our Treatment is very safe andhas clinically shown to differentiate into regenerative pancreatic islet-like cells, demonstrating many of the expected characteristics of real pancreatic islet cells. The new islet cells have the ability to secrete glucagon,insulin and somatostatin.These islet-like clusters express a variety of endocrine specific markers are composed of the key pancreatic cell types (, , ), and are able to synthesize and secrete insulin in a glucose-responsive manner.The Diabetestreatment protocols only uses cells of highest purity, viability and integrity from world quality laboratory and cryogenics facility, which complies with accepted international standards. Cryopreservation is also a cost-effective option for some clients with more severe needs or who may be wanting easy access to matched stem cells for any future treatments. Some patients with severely degenerative medical conditions will require more transplantation cycles to allow better results.

PBSC Collection for Stem Cell Treatment

Diabetic patients are usually treated by injecting the stem cells into the pancreatic artery via catheter tube. Patients who cannot safely undergo the catheterization procedure may receive injections via IV drip (intravenously). Patients who cannot be treated by catheter, such as those with kidney problems, are offered an Intravenous (IV) delivery for the Treatment Diabetes.

The goal of theStem Cell Diabetes treatment is complete abolition ormeasurable reduction of insulindependency by > 50% by the end of 6 months of using the Thai Medical Approved PBSC Therapy in Thailand

Actual Results from TMV Approved Stem Cell Diabetes Treatment in Thailand

Facts About Treatment for Diabetes using Stem CellTransplants

For more information about how stem cell can be used to treat diabetes please take a look some clinical data from US ClinicalTrials.Gov

Autologous Stem Cell Transplants Type 1 Diabetes Safety and Efficacy

TMV has helped thousands of men and women just like youtake control of their health. We have earned the reputation as a trusted organization that will guide you every step of the way with honest answers,medical opinions and fixed prices only. We also offer assistance on many non-medical aspects of your medical trip at no extra cost. Other Stem cell treatments we offer include stem cell treatments for spinal cord injury,stem cells for heart disease,treatment for Autism,treatment for ED,stem cell breast augmentations,cell therapy for arthritis and the new non-surgical stem cell facelift.

The entire Diabetes Stem Cell Therapy plan for Those with Diabetes will require a 14-21 day stay in Thailand and consists of the following phrases:

The cost of the entire 14-21 day treatment programdepends on the patients current health condition and medical needs. To qualify for the treatment and get fixed prices please gather your recent blood checkups such as: CBC Complete Blood Count,HbA1c test, Fasting Glucose and Diabetic Urinalysis and contact us. We also offer all-Inclusive packages that include short term furnished apartments or Hotel near the treatment center,round trip airport transportation and a personal manager for local or translation assistance. The package includes one additional guest at no additional charge.To learn more about stem cell therapy for diabetes please contact us today.

The Journey of a Thousand Miles Starts with a Single Step

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Stem Cell Therapy for Diabetes Cure Hyperglycemia

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What are adult stem cells? [Stem Cell Information]

August 4th, 2016 9:40 am

An adult stem cell is thought to be an undifferentiated cell, found among differentiated cells in a tissue or organ. The adult stem cell can renew itself and can differentiate to yield some or all of the major specialized cell types of the tissue or organ. The primary roles of adult stem cells in a living organism are to maintain and repair the tissue in which they are found. Scientists also use the term somatic stem cell instead of adult stem cell, where somatic refers to cells of the body (not the germ cells, sperm or eggs). Unlike embryonic stem cells, which are defined by their origin (cells from the preimplantation-stage embryo), the origin of adult stem cells in some mature tissues is still under investigation.

Research on adult stem cells has generated a great deal of excitement. Scientists have found adult stem cells in many more tissues than they once thought possible. This finding has led researchers and clinicians to ask whether adult stem cells could be used for transplants. In fact, adult hematopoietic, or blood-forming, stem cells from bone marrow have been used in transplants for more than 40 years. Scientists now have evidence that stem cells exist in the brain and the heart, two locations where adult stem cells were not at firstexpected to reside. If the differentiation of adult stem cells can be controlled in the laboratory, these cells may become the basis of transplantation-based therapies.

The history of research on adult stem cells began more than 60 years ago. In the 1950s, researchers discovered that the bone marrow contains at least two kinds of stem cells. One population, called hematopoietic stem cells, forms all the types of blood cells in the body. A second population, called bone marrow stromal stem cells (also called mesenchymal stem cells, or skeletal stem cells by some), were discovered a few years later. These non-hematopoietic stem cells make up a small proportion of the stromal cell population in the bone marrow and can generate bone, cartilage, and fat cells that support the formation of blood and fibrous connective tissue.

In the 1960s, scientists who were studying rats discovered two regions of the brain that contained dividing cells that ultimately become nerve cells. Despite these reports, most scientists believed that the adult brain could not generate new nerve cells. It was not until the 1990s that scientists agreed that the adult brain does contain stem cells that are able to generate the brain's three major cell typesastrocytes and oligodendrocytes, which are non-neuronal cells, and neurons, or nerve cells.

Adult stem cells have been identified in many organs and tissues, including brain, bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, heart, gut, liver, ovarian epithelium, and testis. They are thought to reside in a specific area of each tissue (called a "stem cell niche"). In many tissues, current evidence suggests that some types of stem cells are pericytes, cells that compose the outermost layer of small blood vessels. Stem cells may remain quiescent (non-dividing) for long periods of time until they are activated by a normal need for more cells to maintain tissues, or by disease or tissue injury.

Typically, there is a very small number of stem cells in each tissue and, once removed from the body, their capacity to divide is limited, making generation of large quantities of stem cells difficult. Scientists in many laboratories are trying to find better ways to grow large quantities of adult stem cells in cell culture and to manipulate them to generate specific cell types so they can be used to treat injury or disease. Some examples of potential treatments include regenerating bone using cells derived from bone marrow stroma, developing insulin-producing cells for type1 diabetes, and repairing damaged heart muscle following a heart attack with cardiac muscle cells.

Scientists often use one or more of the following methods to identify adult stem cells: (1) label the cells in a living tissue with molecular markers and then determine the specialized cell types they generate; (2) remove the cells from a living animal, label them in cell culture, and transplant them back into another animal to determine whether the cells replace (or "repopulate") their tissue of origin.

Importantly, scientists must demonstrate that a single adult stem cell can generate a line of genetically identical cells that then gives rise to all the appropriate differentiated cell types of the tissue. To confirm experimentally that a putative adult stem cell is indeed a stem cell, scientists tend to show either that the cell can give rise to these genetically identical cells in culture, and/or that a purified population of these candidate stem cells can repopulate or reform the tissue after transplant into an animal.

As indicated above, scientists have reported that adult stem cells occur in many tissues and that they enter normal differentiation pathways to form the specialized cell types of the tissue in which they reside.

Normal differentiation pathways of adult stem cells. In a living animal, adult stem cells are available to divide for a long period, when needed, and can give rise to mature cell types that have characteristic shapes and specialized structures and functions of a particular tissue. The following are examples of differentiation pathways of adult stem cells (Figure 2) that have been demonstrated in vitro or in vivo.

Figure 2. Hematopoietic and stromal stem cell differentiation. Click here for larger image. ( 2008 Terese Winslow)

Transdifferentiation. A number of experiments have reported that certain adult stem cell types can differentiate into cell types seen in organs or tissues other than those expected from the cells' predicted lineage (i.e., brain stem cells that differentiate into blood cells or blood-forming cells that differentiate into cardiac muscle cells, and so forth). This reported phenomenon is called transdifferentiation.

Although isolated instances of transdifferentiation have been observed in some vertebrate species, whether this phenomenon actually occurs in humans is under debate by the scientific community. Instead of transdifferentiation, the observed instances may involve fusion of a donor cell with a recipient cell. Another possibility is that transplanted stem cells are secreting factors that encourage the recipient's own stem cells to begin the repair process. Even when transdifferentiation has been detected, only a very small percentage of cells undergo the process.

In a variation of transdifferentiation experiments, scientists have recently demonstrated that certain adult cell types can be "reprogrammed" into other cell types in vivo using a well-controlled process of genetic modification (see Section VI for a discussion of the principles of reprogramming). This strategy may offer a way to reprogram available cells into other cell types that have been lost or damaged due to disease. For example, one recent experiment shows how pancreatic beta cells, the insulin-producing cells that are lost or damaged in diabetes, could possibly be created by reprogramming other pancreatic cells. By "re-starting" expression of three critical beta cell genes in differentiated adult pancreatic exocrine cells, researchers were able to create beta cell-like cells that can secrete insulin. The reprogrammed cells were similar to beta cells in appearance, size, and shape; expressed genes characteristic of beta cells; and were able to partially restore blood sugar regulation in mice whose own beta cells had been chemically destroyed. While not transdifferentiation by definition, this method for reprogramming adult cells may be used as a model for directly reprogramming other adult cell types.

In addition to reprogramming cells to become a specific cell type, it is now possible to reprogram adult somatic cells to become like embryonic stem cells (induced pluripotent stem cells, iPSCs) through the introduction of embryonic genes. Thus, a source of cells can be generated that are specific to the donor, thereby increasing the chance of compatibility if such cells were to be used for tissue regeneration. However, like embryonic stem cells, determination of the methods by which iPSCs can be completely and reproducibly committed to appropriate cell lineages is still under investigation.

Many important questions about adult stem cells remain to be answered. They include:

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What are adult stem cells? [Stem Cell Information]

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Atlanta Georgia Office of the American Diabetes Association

August 4th, 2016 9:40 am

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Adults and children in Georgia are increasingly feeling the effects of diabetes as more than 1,000,000 suffer from this deadly disease, 350,000 of whom don't even know they have it! If present trends continue, it is estimated that one out of every three children, one in two minority children, faces a future with diabetes.

That is why the American Diabetes Association, Atlanta/North Georgia Region office is so committed to educating the public about how to stop diabetes and support those living with this disease.

We are here to help and invite you to join us. You will be helping us to confront it, fight it and stop it.

For information on resources available to the workplace, contact Leslie Potts at lpotts@diabetes.org.

For more information on FREE resources available for your church, contact Leslie Potts at lpotts@diabetes.org.

We welcome your help.

Your involvement as an American Diabetes Association volunteer whether on a local or national level will help us expand our community outreach and impact, inspire healthy living, intensify our advocacy efforts, raise critical dollars to fund our mission, and uphold our reputation as the moving force and trusted leader in the diabetes community.

Find volunteer opportunities in our area through the Volunteer Center.

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Atlanta Georgia Office of the American Diabetes Association

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Kidney Disease Therapy Knowledge-Kidney Failure

August 4th, 2016 9:40 am

What are the current treatment options for kidney diseases? Here is the overview of blood purification technology, kidney transplant, Chinese medicines (acupuncture, cupping therapy, Gua Sha, Qi Gong, massage, Taijiquan, pedicure, medicated bath) and the latest immunotherapy. We will introduce you their adaptable diseases, advantages and disadvantages. You can make the best choice according to your specific illness and physical conditions. Of cause you should consult the doctors for advise and guidance.

Dialysis is to purify the blood and treat renal failure.

Hemodialysis can help remove wastes and sustain life.

Peritoneal dialysis is to use peritoneum as semipermeable membrane.

Plasma exchange uses fresh plasma to replace toxic materials.

Immune adsorption is to use adsorbent to remove pathological factors

Blood perfusion is often combined with hemodialysis in clinic.

Hemofiltration is the exchange of ultrafiltrate and substitute.

Blood pollution treatment is a brand new treatment for kidney disease.

Acupuncture is to use needles to activate meridians and acupuncture points.

Cupping therapy is to use pots to cause congestion or blood stasis.

Gual Sha is to use jade or horn to rub certain parts of the skin.

Massage is friction, knead or knocking of the surface of body.

Qigong is regulation of respiration, physical and mental activity.

Taijiquan is one type of Chinese Kong fu for building up physical strength.

Medicated bath is to treat disease by taking bath with medicines in water.

Pedicure is to stimulate the reflection zone in the feet.

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Kidney Disease Therapy Knowledge-Kidney Failure

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Regenerative Medicine Conferences | Europe | Worldwide …

August 4th, 2016 9:40 am

The 5th International Conference on Tissue Engineering & Regenerative Medicine which is going to be held during September 12-14, 2016 at Berlin, Germany will bring together world-class personalities working on stem cells, tissue engineering and regenerative medicine to discuss materials-related strategies for disease remediation and tissue repair.

Tissue Regeneration

In the field of biology, regeneration is the progression of renewal, regeneration and growth that makes it possible for genomes, cells, organ regeneration to natural changes or events that cause damage or disturbance.This study is carried out as craniofacial tissue engineering, in-situ tissue regeneration, adipose-derived stem cells for regenerative medicine which is also a breakthrough in cell culture technology. The study is not stopped with the regeneration of tissue where it is further carried out in relation with cell signaling, morphogenetic proteins. Most of the neurological disorders occurred accidental having a scope of recovery by replacement or repair of intervertebral discs repair, spinal fusion and many more advancements. The global market for tissue engineering and regeneration products such as scaffolds, tissue implants, biomimetic materials reached $55.9 billion in 2010 and it is expected to reach $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%. It grows to $135 billion by 2024.

Related Conferences

International Conference on Cancer Immunology and Immunotherapy July 28-30, 2016 Melbourne, Australia; International Conference on Molecular Biology October 13-15, 2016 Dubai, UAE; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany; 6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 5th International Conference and Exhibition on Cell and Gene Therapy May 19-21, 2016 San Antonio, USA; Tissue Niches & Resident Stem Cells in Adult Epithelia Gordon Research Conference, Regulation of Tissue Homeostasis by Signaling in the Stem Cell Niche August 7-12,Hong Kong, China; 10 Years of IPSCs, Cell Symposia, September 25-27, 2016Berkeley, CA, USA; The Company of Biologists Workshops: From Stem Cells to Human Development September 25-28, 2016Southbridge, MA, USA; World Stem Cells & Regenerative Medicine Congress May 18-20, 2016 London, UK; Notch Signaling in Development, Regeneration & Disease Gordon Research Conference, July 31-August 5, 2016Lewiston, ME, USA

Designs for Tissue Engineering

The developing field of tissue engineering aims to regenerate damaged tissues by combining cells from the body with bioresorbable materials, biodegradable hydrogel, biomimetic materials, nanostructures and nanomaterials, biomaterials and tissue implants which act as templates for tissue regeneration, to guide the growth of new tissue by using with the technologies. The global market for biomaterials, nanostructures and bioresorbable materials are estimated to reach $88.4 billion by 2017 from $44.0 billion in 2012 growing at a CAGR of 15%. Further the biomaterials market estimated to be worth more than 300 billion US Dollars and to be increasing 20% per year.

Related Conferences

6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 5th International Conference and Exhibition on Cell and Gene Therapy May 19-21, 2016 San Antonio, USA; International Conference on Restorative Medicine October 24-26, 2016 Chicago, USA; International Conference on Molecular Biology October 13-15, 2016 Dubai, UAE; 2nd International Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; ISSCR 14th Annual Meeting 22-25 June, 2016San Francisco, California, USA; Keystone Cardiac Development, Regeneration and Repair (Z2) April 3 7, 2016Snowbird, Utah, USA; The Stem Cell NicheDevelopment & Disease May 22-26, 2016Hillerd, Denmark; EMBL Hematopoietic Stem Cells: From the Embryo to the Aging Organism, June 3-5, 2016Heidelberg, Germany; ISSCR Pluripotency: From basic science to therapeutic applications March 22-24, 2016 Kyoto, Japan

Organ Engineering

This interdisciplinary engineering has attracted much attention as a new therapeutic means that may overcome the drawbacks involved in the current artificial organs and organ transplantation that have been also aiming at replacing lost or severely damaged tissues or organs. Tissue engineering and regenerative medicine is an exciting research area that aims at regenerative alternatives to harvested tissues for organ transplantation with soft tissues. Although significant progress has been made in the tissue engineering field, many challenges remain and further development in this area will require ongoing interactions and collaborations among the scientists from multiple disciplines, and in partnership with the regulatory and the funding agencies. As a result of the medical and market potential, there is significant academic and corporate interest in this technology.

Related Conferences

International Conference on Restorative Medicine October 24-26, 2016 Chicago, USA; 5th International Conference and Exhibition on Cell and Gene Therapy May 19-21, 2016 San Antonio, USA; 6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany;2ndInternational Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA;Phacilitate Cell & Gene Therapy WorldJanuary 25-27, 2016Washington D.C., USA;ISSCR Stem Cell Models of Neural Degeneration and DiseaseFebruary 1-3, 2016Dresden, Germany;Craniofacial Morphogenesis & Tissue RegenerationMarch 12-18, 2016California, USA;Keystone Stem Cells and Cancer (C1)March 6-10,Colorado, USA;Keystone Stem Cells and Regeneration in the Digestive Organs (X6)March 13 17Colorado, USA

CancerStem Cells

The characterization of cancer stem cell is done by identifying the cell within a tumor that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. This stem cell which acts as precursor for the cancer acts as a tool against it indulging the reconstruction of cancer stem cells, implies as the therapeutic implications and challenging the gaps globally. The global stem cell market will grow from about $5.6 billion in 2013 to nearly $10.6 billion in 2018, registering a compound annual growth rate (CAGR) of 3.6% from 2013 through 2018. The Americas is the largest region of global stem cell market, with a market share of about $2.0 billion in 2013. The region is projected to increase to nearly $3.9 billion by 2018, with a CAGR of 13.9% for the period of 2013 to 2018. Europe is the second largest segment of the global stem cell market and is expected to grow at a CAGR of 13.4% reaching about $2.4 billion by 2018 from nearly $1.4 billion in 2013.

Related Conferences

6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 5th International Conference and Exhibition on Cell and Gene Therapy May 19-21, 2016 San Antonio, USA; International Conference on Molecular Biology October 13-15, 2016 Dubai, UAE; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany;2ndInternational Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; Molecular and Cellular Basis of Growth and Regeneration (A3) January 10 14, 2016Colorado, USA; Phacilitate Cell & Gene Therapy World January 25-27, 2016Washington D.C., USA; ISSCR Stem Cell Models of Neural Degeneration and Disease March 13 17, 2016Dresden, Germany; Craniofacial Morphogenesis & Tissue Regeneration March 12-18, 2016California, USA; World Stem Cells & Regenerative Medicine Congress May 18-20, 2016 London, UK

Bone Tissue Engineering

Tissue engineering of musculoskeletal tissues, particularly bone and cartilage, is a rapidly advancing field. In bone, technology has centered on bone graft substitute materials and the development of biodegradable scaffolds. Recently, tissue engineering strategies have included cell and gene therapy. The availability of growth factors and the expanding knowledge base concerning the bone regeneration with modern techniques like recombinant signaling molecules, solid free form fabrication of scaffolds, synthetic cartilage, Electrochemical deposition, spinal fusion and ossification are new generated techniques for tissue-engineering applications. The worldwide market for bone and cartilage repairs strategies is estimated about $300 million. During the last 10/15 years, the scientific community witnessed and reported the appearance of several sources of stem cells with both osteo and chondrogenic potential.

Related Conferences

5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany; 6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 3rd2nd International Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; 5th International Conference and Exhibition on Cell and Gene Therapy May 19-21, 2016 San Antonio, USA; International Conference on Restorative Medicine October 24-26, 2016 Chicago, USA;10th World Biomaterials Congress May 17-22, 2016 Quebec, Canada;2016 TERMIS-EU Conference June 28- July1, 2016 Uppsala, Sweden; 2016 TERMIS-AP Conference Tamsui Town of New Taipei CityMay 23-28, 2016;2016 TERMIS-AM Conference September 3-6, 2016, San Diego, USA; Pluripotency: From basic science to therapeutic applications 22-24 March 2016 Kyoto, Japan

Scaffolds

Scaffolds are one of the three most important elements constituting the basic concept of regenerative medicine, and are included in the core technology of regenerative medicine. Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease or trauma. The developing field of tissue engineering (TE) aims to regenerate damaged tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for tissue regeneration, to guide the growth of new tissue. Scaffolds has a prominent role in tissue regeneration the designs, fabrication, 3D models, surface ligands and molecular architecture, nanoparticle-cell interactions and porous of the scaffolds are been used in the field in attempts to regenerate different tissues and organs in the body. The world stem cell market was approximately 2.715 billion dollars in 2010, and with a growth rate of 16.8% annually, a market of 6.877 billion dollars will be formed in 2016. From 2017, the expected annual growth rate is 10.6%, which would expand the market to 11.38 billion dollars by 2021.

Related Conferences

4th International Congress on Bacteriology and Infectious Diseases May 16-18, 2016 San Antonio, USA; 2nd World Congress and Expo on Applied Microbiology October 31-November 02, 2016 Istanbul, Turkey; International Conference on Infectious Diseases & Diagnostic Microbiology Oct 3-5, 2016 Vancouver, Canada; International Conference on Water Microbiology & Novel Technologies July 18-20, 2016 Chicago, USA; 5th International Conference on Clinical Microbiology and Microbial Genomics October 24-26, 2016 Rome, Italy; Annual Meeting of the German Society for Gene Therapy 12 - 13 March 2015 Vienna, Austria; International Bone-Tissue-Engineering Congress 8 - 10 October 2015. Stuttgart, Germany; Till & McCulloch Meetings October 26-28, 2015 Toronto, Canada; 9th International Symposium on Neuroprotection and Neurorepair April 19 to April 22, 2016 Magdeburg, Germany; Craniofacial Morphogenesis & Tissue Regeneration March 12-18, 2016California, USA

Tissue Regeneration Technologies

Guided tissue regeneration is defined as procedures attempting to regenerate lost periodontal structures through differential tissue responses. Guided bone regeneration typically refers to ridge augmentation or bone regenerative procedures it typically refers to regeneration of periodontal therapy. The recent advancements and innovations in biomedical and regenerative tissue engineering techniques include the novel approach of guided tissue regeneration and combination of nanotechnology and regenerative medicine.

Related Conferences

3rd International Conference on Gynecology & Obstetrics October 17-19, 2016 Dubai, UAE; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany; 6th World Congress on Cell & Stem Cell Research February 29-March 02, 2016 Philadelphia, USA; 2nd International Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; International Conference on Restorative Medicine October 24-26, 2016 Chicago; 2016 Annual Convention & Exposition June 6-9, 2016 Philadelphia, USA;3rd International Conference on BioTribology - ICoBT 2016 September 11-14, 2016 London, UK; International Symposium on Endovascular Therapy - ISET February 6-10, 2016Florida, USA; International Bone Tissue Engineering Congress October 810 , 2015Stuttgart, Germany

Regeneration and Therapeutics

Regenerative medicinecan be defined as a therapeutic intervention which replaces or regenerates human cells, tissues or organs, to restore or establish normal function and deploys small molecule drugs, biologics, medical devices and cell-based therapies. It deals with the different therapeutic uses like stem cells for tissue repair, tissue injury and healing process, cardiac stem cell therapy for regeneration, functional regenerative recovery, effects of aging on tissue repair/regeneration, corneal regeneration & degeneration. The global market is expected to reach $25.5 billion by 2011 and will further grow to $36.1 billion by 2016 at a CAGR of 7.2%. It is expected to reach $65 billion mark by 2024.

Related Conferences

World Congress on Human Genetics October 31- November 02, 2016 Valencia, Spain; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany; 2nd International Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; European Conference on Genomics and Personalized Medicine April 25-27, 2016 Valencia, Spain; 4th International Conference on Plant Genomics July 14-15, 2016 Brisbane, Australia; World Stem Cells & Regenerative Medicine Congress May 18-20, 2016 London, UK; 18th International Conference on Tissue Engineering and Regenerative Medicine Applications May 12 - 13, 2016 Amsterdam, Netherlands; 18th International Conference on Bone, Muscle and Joint Diseases February 25 - 26, 2016 London, UK; 2nd Conference on Tissue Engineering and Regenerative Medicine March 18 to 20, 2016 Los Angeles, USA;

Regenerative medicine

Regenerative medicine is a branch of translational research in tissue engineering and molecular biology which deals with the process of replacing, engineering or regenerating human cells, tissues or organs to restore or establish normal function. The latest developments involve advances in cell and gene therapy and stem cell research, molecular therapy, dental and craniofacial regeneration. Regenerative medicines have the unique ability to repair, replace and regenerate tissues and organs, affected due to some injury, disease or due to natural aging process. These medicines are capable of restoring the functionality of cells and tissues. The global regenerative medicine market will reach $ 67.6 billion by 2020 from $16.4 billion in 2013, registering a CAGR of 23.2% during forecast period (2014 - 2020). Small molecules and biologics segment holds prominent market share in the overall regenerative medicine technology market and is anticipated to grow at a CAGR of 18.9% during the forecast period.

Related Conferences

International Conference on Next Generation Sequencing July 21-22, 2016 Berlin, Germany; 5th International Conference on Computational Systems Biology August 22-23, 2016 Philadelphia, USA; 7th International Conference on Bioinformatics October 27-28, 2016 Chicago, USA; International Conference on Synthetic Biology September 28-30, 2015 Houston, USA; 4th International Conference on Integrative Biology July 18-20, 2016 Berlin, Germany; World Conference on Regenerative Medicine October 2123, 2015 Lepizig, Germany; World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases April 14-17 2016 Malga, Spain; Bioinspired Materials Gordon Research Conference June 5-10, 2016, Girona, Spain

Applications of Tissue Engineering

The applications of tissue engineering and regenerative medicine are innumerable as they mark the replacement of medication and organ replacement. The applications involve cell tracking and tissue imaging, cell therapy and regenerative medicine, organ harvesting, transport and transplant, the application of nanotechnology in tissue engineering and regenerative medicine and bio banking. Globally the research statistics are increasing at a vast scale and many universities and companies are conducting events on the subject regenerative medicine conference like tissue implants workshops, endodontics meetings, tissue biomarkers events, tissue repair meetings, regenerative medicine conferences, tissue science conference, regenerative medicine workshop, veterinary regenerative medicine, regenerative medicine symposiums, tissue regeneration conferences, regenerative medicine congress.

Related Conferences

World Congress on Human Genetics October 31- November 02, 2016 Valencia, Spain; 5th International Conference on Tissue Science and Regenerative Medicine September 12-14, 2016 Berlin, Germany; 2nd International Conference & Exhibition on Tissue preservation and Bio-banking August 18-19, 2016 Portland, USA; European Conference on Genomics and Personalized Medicine April 25-27, 2016 Valencia, Spain; 4th International Conference on Plant Genomics July 14-15, 2016 Brisbane, Australia; Biocatalysis (GRS) Gordon Research Seminar Jul 9-10, 2016 New England, UK; World Conference on Regenerative Medicine October 2123, 2015 Lepizig, Germany; 18thInternational Conference on Tissue Engineering and Regenerative Medicine Applications May 12 - 13, 2016 Amsterdam, Netherlands; International Bone-Tissue-Engineering Congress 8 - 10 October 2015. Stuttgart, Germany; Craniofacial Morphogenesis & Tissue Regeneration March 12-18, 2016California, USA.

Market Analysis in Regenerative Medicine:

There are strong pricing pressures from public healthcare payers globally as Governments try to reduce budget deficits. Regenerative medicine could potentially save public health bodies money by reducing the need for long-term care and reducing associated disorders, with potential benefits for the world economy as a whole.The global market for tissue engineering and regeneration products reached $55.9 billion in 2010, is expected to reach $59.8 billion by 2011, and will further grow to $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%. It grows to $135 billion to 2024. The contribution of the European region was 43.3% of the market in 2010, a value of $24.2 billion. The market is expected to reach $25.5 billion by 2011 and will further grow to $36.1 billion by 2016 at a CAGR of 7.2%. It grows to $65 billion to 2024.

Related Conferences

2ndInternational Conference & Exhibition on Tissue preservation andBio-bankingAugust 18-19, 2016 Portland, USA; European Conference on Genomics andPersonalized MedicineApril 25-27, 2016 Valencia, Spain;3rdInternational Conference onGynecology& Obstetrics October 17-19, 2016 Dubai, UAE; 5thInternational Conference on Tissue Science andRegenerative MedicineSeptember 12-14, 2016 Berlin, Germany; 6thWorld Congress on Cell &Stem Cell ResearchFebruary 29-March 02, 2016 Philadelphia, USA;18thInternational Conference on Bone, Muscle andJoint DiseasesFebruary 25 - 26, 2016 London, UK; 2ndConference on Tissue Engineering andRegenerative MedicineMarch 18 to 20, 2016 Los Angeles, USA;InternationalBone-Tissue-Engineering Congress 8 - 10 October 2015. Stuttgart, Germany; CraniofacialMorphogenesis& Tissue Regeneration March 12-18, 2016California, USA.

Market Analysis Report:

Tissue engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. Regenerative medicine is not one discipline. It can be defined as a therapeutic intervention which replaces or regenerates human cells, tissues or organs, to restore or establish normal function and deploys small molecule drugs, biologics, medical devices and cell-based therapies

Currently it has emerged as a rapidly diversifying field with the potential to address the worldwide organ shortage issue and comprises of tissue regeneration and organ replacement. Regenerative medicine could potentially save public health bodies money by reducing the need for long-term care and reducing associated disorders, with potential benefits for the world economy as a whole.The global tissue engineering and regeneration market reached $17 billion in 2013. This market is expected to grow to nearly $20.8 billion in 2014 and $56.9 billion in 2019, a compound annual growth rate (CAGR) of 22.3%. On the basis of geography, Europe holds the second place in the global market in the field of regenerative medicine & tissue engineering. In Europe countries like UK, France and Germany are possessing good market shares in the field of regenerative medicine and tissue engineering. Spain and Italy are the emerging market trends for tissue engineering in Europe.

Tissue engineering is "an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. Currently it has emerged as a rapidly diversifying field with the potential to address the worldwide organ shortage issue and comprises of tissue regeneration and organ replacement. A novel set of tissue replacement parts and implementation strategies had shown a great revolution in this field. Cells placed on or within the tissue constructs is the most common methodology in tissue engineering.

Regenerative medicine is not one discipline. It can be defined as a therapeutic intervention which replaces or regenerates human cells, tissues or organs, to restore or establish normal function and deploys small molecule drugs, biologics, medical devices and cell-based therapies

This field continues to evolve. In addition to medical applications, non-therapeutic applications include using tissues as biosensors to detect biological or chemical threat agents, and tissue chips that can be used to test the toxicity of an experimental medication. Tissue Engineering and Regenerative Medicine is the major field in Medicine, which is still under research and the advancements are maximizing day to day.

Regenerative Medicine-2015 is an engrossed a vicinity of cognizant discussions on novel subjects like Tissue Regeneration, Materials & Designs for Tissue Engineering, Stem CellTools to Battle Cancer, Bioreactors in Tissue Engineering, Regeneration & Therapeutics, Cord Blood & Regenerative Medicine and Clinical Medicine, to mention a few. The three days event implants a firm relation of upcoming strategies in the field of Tissue Science & Regenerative Medicine with the scientific community. The conceptual and applicable knowledge shared, will also foster organizational collaborations to nurture scientific accelerations.We bring together business, creative, and technology leaders from the tissue engineering, marketing, and research industry for the most current and relevant.

Berlin is one of the largest and most diverse science regions in Europe. Roughly 200,000 people from around the world teach, research, work and study here. Approximately 17 percent of all students come from abroad, most of them from China, Russia and the USA. Many cooperative programs link Berlins institutes of higher education with partner institutes around the world. Berlin is a city of science at the heart of Europe a city whose history of scientific excellence stems from its many important research institutions and its long track record of scientific breakthroughs. Berlin has numerous modern Technology Centers. Their science-oriented infrastructure makes them attractive locations for young, technology-oriented companies.

Germany places great emphasis on globally networked research cooperation. Many organizations support international researchers and academics: Today more than 32,000 are being supported with scholarships. Besides this, research funding in Germany has the goal of financing the development of new ideas and technologies. The range covers everything from basic research in natural sciences, new technologies to structural research funding at institutions of higher education. On the basis of geography, the regenerative medicine bone and joint market Europe hold the second place in the global market in the field of regenerative medicine & tissue engineering. The market growth is expected to reach $65 billion by 2024 in Europe. In Europe countries like UK, France, and Germany are possessing good market share in the field of regenerative medicine and tissue engineering. Spain and Italy are the emerging market trends for tissue engineering in Europe. As per the scope and emerging market for tissue engineering and regenerative medicine Berlin has been selected as Venue for the 5th International Conference on Tissue Science and Regenerative Medicine.

Meet Your Target MarketWith members from around the world focused on learning about Advertising and marketing, this is the single best opportunity to reach the largest assemblage of participants from the tissue engineering and regenerative medicine community. The meeting engrossed a vicinity of cognizant discussions on novel subjects like Tissue Regeneration, Materials & Designs for Tissue Engineering, Stem CellTools to Battle Cancer, Bioreactors in Tissue Engineering, Regeneration & Therapeutics, Cord Blood & Regenerative Medicine and Clinical Medicine, to mention a few. The three days event implants a firm relation of upcoming strategies in the field of Tissue Engineering & Regenerative Medicine with the scientific community. The conceptual and applicable knowledge shared, will also foster organizational collaborations to nurture scientific accelerations.Conduct demonstrations, distribute information, meet with current and potential customers, make a splash with a new product line, and receive name recognition.

International Stem Cell Forum (ISCF)

International Society for Stem Cell Research (ISSCR)

UK Medical Research Council (MRC)

Australian Stem Cell Center

Canadian Institutes of Health Research (CIHR)

Euro Stem Cell (ACR)

Center for Stem Cell Biology

Stem Cell Research Singapore

UK National Stem Cell Network

Spain Mobile Marketing Association

European Marketing Confederation (EMC)

European Letterbox Marketing Association(ELMA)

European Sales & Marketing Association (ESMA)

The Incentive Marketing Association (IMA Europe)

European Marketing Academy

Figure 1: Statistical Analysis of Societies and Associations

Source: Reference7

Presidents or Vice Presidents/ Directors of Associations and Societies, CEOs of the companies associated with regenerative medicine and tissue engineering Consumer Products. Retailers, Marketing, Advertising and Promotion Agency Executives, Solution Providers (digital and mobile technology, P-O-P design, retail design, and retail execution), Professors and Students from Academia in the study of Marketing and Advertising filed.

Industry 40%

Academia 50%

Others 10%

Figure 2: Target Audience

Technische University Munchen

University of Wrzburg

University Medical Center

University of Tubingen

Universittsklinikum Mnster

Technische Universitt Dresden

Leipzig University

University Medicine of Rostock

Institut fur Humangenetik und Anthropologie der Universitat

Otto-von-Guericke University

Hannover Medical School

Max Planck Institute

Figure 3: Top Universities in Germany

There are strong pricing pressures from public healthcare payers globally as Governments try to reduce budget deficits. Regenerative medicine could potentially save public health bodies money by reducing the need for long-term care and reducing associated disorders, with potential benefits for the world economy as a whole.The global market for tissue engineering and regeneration products reached $55.9 billion in 2010, is expected to reach $59.8 billion by 2011, and will further grow to $89.7 billion by 2016 at a compounded annual growth rate (CAGR) of 8.4%. It grows to $135 billion to 2024

The contribution of the European region was 43.3% of the market in 2010, a value of $24.2 billion. The market is expected to reach $25.5 billion by 2011 and will further grow to $36.1 billion by 2016 at a CAGR of 7.2%. It grows to $65 billion to 2024. [Source: Reference2]

Figure 4: Global Market Growth of Tissue Engineering and Regenerative Medicine

Figure 5: Industries associated with Tissue Engineering and Regenerative Medicine

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Alternative medicine – Wikipedia, the free encyclopedia

August 4th, 2016 9:40 am

Alternative medicine is any practice that is put forward as having the healing effects of medicine, but does not originate from evidence gathered using the scientific method,[n 1][n 2][n 3] is not part of biomedicine,[n 1][n 4][n 5][n 6] or is contradicted by scientific evidence or established science.[1][2][3] It consists of a wide range of health care practices, products and therapies, ranging from being biologically plausible but not well tested, to being directly contradicted by evidence and science, or even harmful or toxic.[n 4][1][3][4][5][6] Examples include new and traditional medicine practices such as homeopathy, naturopathy, chiropractic, energy medicine, various forms of acupuncture, traditional Chinese medicine, Ayurvedic medicine, Sekkotsu, and Christian faith healing. The treatments are those that are not part of the science-based healthcare system, and are not clearly backed by scientific evidence.[7][8][10] Despite significant expenditures on testing alternative medicine, including $2.5 billion spent by the United States government, almost none have shown any effectiveness greater than that of false treatments (placebo), and alternative medicine has been criticized by prominent figures in science and medicine as being quackery, nonsense, fraudulent, or unethical.[11][12]

Complementary medicine is alternative medicine used together with conventional medical treatment, in a belief not confirmed using the scientific method that it "complements" (improves the efficacy of) the treatment.[n 7][14][15][16]CAM is the abbreviation for complementary and alternative medicine.[17][18]Integrative medicine (or integrative health) is the combination of the practices and methods of alternative medicine with conventional medicine.[19]

Alternative medical diagnoses and treatments are not included as science-based treatments that are taught in medical schools, and are not used in medical practice where treatments are based on what is established using the scientific method. Alternative therapies lack such scientific validation, and their effectiveness is either unproved or disproved.[n 8][1][14][21][22] Alternative medicine is usually based on religion, tradition, superstition, belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, or fraud.[1][2][3][14] Regulation and licensing of alternative medicine and health care providers varies from country to country, and state to state.

The scientific community has criticized alternative medicine as being based on misleading statements, quackery, pseudoscience, antiscience, fraud, or poor scientific methodology. Promoting alternative medicine has been called dangerous and unethical.[n 9][24] Testing alternative medicine has been called a waste of scarce medical research resources.[25][26] Critics have said "there is really no such thing as alternative medicine, just medicine that works and medicine that doesn't",[27] and "Can there be any reasonable 'alternative' [to medicine based on evidence]?"[28]

Alternative medicine consists of a wide range of health care practices, products, and therapies. The shared feature is a claim to heal that is not based on the scientific method. Alternative medicine practices are diverse in their foundations and methodologies.[7] Alternative medicine practices may be classified by their cultural origins or by the types of beliefs upon which they are based.[1][2][7][14] Methods may incorporate or base themselves on traditional medicinal practices of a particular culture, folk knowledge, supersition, spiritual beliefs, belief in supernatural energies (antiscience), pseudoscience, errors in reasoning, propaganda, fraud, new or different concepts of health and disease, and any bases other than being proven by scientific methods.[1][2][3][14] Different cultures may have their own unique traditional or belief based practices developed recently or over thousands of years, and specific practices or entire systems of practices.

Alternative medical systems can be based on common belief systems that are not consistent with facts of science, such as in naturopathy or homeopathy.[7]

Homeopathy is a system developed in a belief that a substance that causes the symptoms of a disease in healthy people will cure similar symptoms in sick people.[n 10] It was developed before knowledge of atoms and molecules, and of basic chemistry, which shows that repeated dilution as practiced in homeopathy produces only water and that homeopathy is scientifically implausible.[31][32][33][34] Homeopathy is considered quackery in the medical community.[35]

Naturopathic medicine is based on a belief that the body heals itself using a supernatural vital energy that guides bodily processes,[36] a view in conflict with the paradigm of evidence-based medicine.[37] Many naturopaths have opposed vaccination,[38] and "scientific evidence does not support claims that naturopathic medicine can cure cancer or any other disease".[39]

Alternative medical systems may be based on traditional medicine practices, such as traditional Chinese medicine, Ayurveda in India, or practices of other cultures around the world.[7]

Traditional Chinese medicine is a combination of traditional practices and beliefs developed over thousands of years in China, together with modifications made by the Communist party. Common practices include herbal medicine, acupuncture (insertion of needles in the body at specified points), massage (Tui na), exercise (qigong), and dietary therapy. The practices are based on belief in a supernatural energy called qi, considerations of Chinese Astrology and Chinese numerology, traditional use of herbs and other substances found in China, a belief that a map of the body is contained on the tongue which reflects changes in the body, and an incorrect model of the anatomy and physiology of internal organs.[1][40][41][42][43][44]

The Chinese Communist Party Chairman Mao Zedong, in response to the lack of modern medical practitioners, revived acupuncture and its theory was rewritten to adhere to the political, economic and logistic necessities of providing for the medical needs of China's population.[45][pageneeded] In the 1950s the "history" and theory of traditional Chinese medicine was rewritten as communist propaganda, at Mao's insistence, to correct the supposed "bourgeois thought of Western doctors of medicine".Acupuncture gained attention in the United States when President Richard Nixon visited China in 1972, and the delegation was shown a patient undergoing major surgery while fully awake, ostensibly receiving acupuncture rather than anesthesia. Later it was found that the patients selected for the surgery had both a high pain tolerance and received heavy indoctrination before the operation; these demonstration cases were also frequently receiving morphine surreptitiously through an intravenous drip that observers were told contained only fluids and nutrients.[40]Cochrane reviews found acupuncture is not effective for a wide range of conditions.[47] A systematic review of systematic reviews found that for reducing pain, real acupuncture was no better than sham acupuncture.[48] Although, other reviews have found that acupuncture is successful at reducing chronic pain, where as sham acupuncture was not found to be better than a placebo as well as no-acupuncture groups.[49]

Ayurvedic medicine is a traditional medicine of India. Ayurveda believes in the existence of three elemental substances, the doshas (called Vata, Pitta and Kapha), and states that a balance of the doshas results in health, while imbalance results in disease. Such disease-inducing imbalances can be adjusted and balanced using traditional herbs, minerals and heavy metals. Ayurveda stresses the use of plant-based medicines and treatments, with some animal products, and added minerals, including sulfur, arsenic, lead, copper sulfate.[citation needed]

Safety concerns have been raised about Ayurveda, with two U.S. studies finding about 20 percent of Ayurvedic Indian-manufactured patent medicines contained toxic levels of heavy metals such as lead, mercury and arsenic. Other concerns include the use of herbs containing toxic compounds and the lack of quality control in Ayurvedic facilities. Incidents of heavy metal poisoning have been attributed to the use of these compounds in the United States.[5][52][53][54]

Bases of belief may include belief in existence of supernatural energies undetected by the science of physics, as in biofields, or in belief in properties of the energies of physics that are inconsistent with the laws of physics, as in energy medicine.[7]

Biofield therapies are intended to influence energy fields that, it is purported, surround and penetrate the body.[7] Writers such as noted astrophysicist and advocate of skeptical thinking (Scientific skepticism) Carl Sagan (1934-1996) have described the lack of empirical evidence to support the existence of the putative energy fields on which these therapies are predicated.

Acupuncture is a component of traditional Chinese medicine. In acupuncture, it is believed that a supernatural energy called qi flows through the universe and through the body, and helps propel the blood, blockage of which leads to disease.[41] It is believed that insertion of needles at various parts of the body determined by astrological calculations can restore balance to the blocked flows, and thereby cure disease.[41]

Chiropractic was developed in the belief that manipulating the spine affects the flow of a supernatural vital energy and thereby affects health and disease.

In the western version of Japanese Reiki, the palms are placed on the patient near Chakras, believed to be centers of supernatural energies, in a belief that the supernatural energies can transferred from the palms of the practitioner, to heal the patient.

Bioelectromagnetic-based therapies use verifiable electromagnetic fields, such as pulsed fields, alternating-current, or direct-current fields in an unconventional manner.[7]Magnetic healing does not claim existence of supernatural energies, but asserts that magnets can be used to defy the laws of physics to influence health and disease.

Mind-body medicine takes a holistic approach to health that explores the interconnection between the mind, body, and spirit. It works under the premise that the mind can affect "bodily functions and symptoms".[7] Mind body medicines includes healing claims made in yoga, meditation, deep-breathing exercises, guided imagery, hypnotherapy, progressive relaxation, qi gong, and tai chi.[7]

Yoga, a method of traditional stretches, exercises, and meditations in Hinduism, may also be classified as an energy medicine insofar as its healing effects are believed to be due to a healing "life energy" that is absorbed into the body through the breath, and is thereby believed to treat a wide variety of illnesses and complaints.[56]

Since the 1990s, tai chi (t'ai chi ch'uan) classes that purely emphasise health have become popular in hospitals, clinics, as well as community and senior centers. This has occurred as the baby boomers generation has aged and the art's reputation as a low-stress training method for seniors has become better known.[57][58] There has been some divergence between those that say they practice t'ai chi ch'uan primarily for self-defence, those that practice it for its aesthetic appeal (see wushu below), and those that are more interested in its benefits to physical and mental health.

Qigong, chi kung, or chi gung, is a practice of aligning body, breath, and mind for health, meditation, and martial arts training. With roots in traditional Chinese medicine, philosophy, and martial arts, qigong is traditionally viewed as a practice to cultivate and balance qi (chi) or what has been translated as "life energy".[59]

Substance based practices use substances found in nature such as herbs, foods, non-vitamin supplements and megavitamins, animal and fungal products, and minerals, including use of these products in traditional medical practices that may also incorporate other methods.[7][12][60] Examples include healing claims for nonvitamin supplements, fish oil, Omega-3 fatty acid, glucosamine, echinacea, flaxseed oil, and ginseng.[61]Herbal medicine, or phytotherapy, includes not just the use of plant products, but may also include the use of animal and mineral products.[12] It is among the most commercially successful branches of alternative medicine, and includes the tablets, powders and elixirs that are sold as "nutritional supplements".[12] Only a very small percentage of these have been shown to have any efficacy, and there is little regulation as to standards and safety of their contents.[12] This may include use of known toxic substances, such as use of the poison lead in traditional Chinese medicine.[61]

Manipulative and body-based practices feature the manipulation or movement of body parts, such as is done in bodywork and chiropractic manipulation.

Osteopathic manipulative medicine, also known as osteopathic manipulative treatment, is a core set of techniques of osteopathy and osteopathic medicine distinguishing these fields from mainstream medicine.[62]

Religion based healing practices, such as use of prayer and the laying of hands in Christian faith healing, and shamanism, rely on belief in divine or spiritual intervention for healing.

Shamanism is a practice of many cultures around the world, in which a practitioner reaches an altered states of consciousness in order to encounter and interact with the spirit world or channel supernatural energies in the belief they can heal.[63]

Some alternative medicine practices may be based on pseudoscience, ignorance, or flawed reasoning.[64] This can lead to fraud.[1]

Practitioners of electricity and magnetism based healing methods may deliberately exploit a patient's ignorance of physics in order to defraud them.[14]

"Alternative medicine" is a loosely defined set of products, practices, and theories that are believed or perceived by their users to have the healing effects of medicine,[n 2][n 4] but whose effectiveness has not been clearly established using scientific methods,[n 2][n 3][1][3][20][22] whose theory and practice is not part of biomedicine,[n 4][n 1][n 5][n 6] or whose theories or practices are directly contradicted by scientific evidence or scientific principles used in biomedicine.[1][2][3] "Biomedicine" is that part of medical science that applies principles of biology, physiology, molecular biology, biophysics, and other natural sciences to clinical practice, using scientific methods to establish the effectiveness of that practice. Alternative medicine is a diverse group of medical and health care systems, practices, and products that originate outside of biomedicine,[n 1] are not considered part of biomedicine,[7] are not widely used by the biomedical healthcare professions,[69] and are not taught as skills practiced in biomedicine.[69] Unlike biomedicine,[n 1] an alternative medicine product or practice does not originate from the sciences or from using scientific methodology, but may instead be based on testimonials, religion, tradition, superstition, belief in supernatural energies, pseudoscience, errors in reasoning, propaganda, fraud, or other unscientific sources.[n 3][1][3][14] The expression "alternative medicine" refers to a diverse range of related and unrelated products, practices, and theories, originating from widely varying sources, cultures, theories, and belief systems, and ranging from biologically plausible practices and products and practices with some evidence, to practices and theories that are directly contradicted by basic science or clear evidence, and products that have proven to be ineffective or even toxic and harmful.[n 4][4][5]

"Alternative medicine", "complementary medicine", "holistic medicine", "natural medicine", "unorthodox medicine", "fringe medicine", "unconventional medicine", and "new age medicine" may be used interchangeably as having the same meaning (synonyms) in some contexts,[70][71][72] but may have different meanings in other contexts, for example, unorthodox medicine may refer to biomedicine that is different from what is commonly practiced, and fringe medicine may refer to biomedicine that is based on fringe science, which may be scientifically valid but is not mainstream.

The meaning of the term "alternative" in the expression "alternative medicine", is not that it is an actual effective alternative to medical science, although some alternative medicine promoters may use the loose terminology to give the appearance of effectiveness.[1]Marcia Angell stated that "alternative medicine" is "a new name for snake oil. There's medicine that works and medicine that doesn't work."[73] Loose terminology may also be used to suggest meaning that a dichotomy exists when it does not, e.g., the use of the expressions "western medicine" and "eastern medicine" to suggest that the difference is a cultural difference between the Asiatic east and the European west, rather than that the difference is between evidence-based medicine and treatments which don't work.[1]

"Complementary medicine" refers to use of alternative medical treatments alongside conventional medicine, in the belief that it increases the effectiveness of the science-based medicine.[74][75][76] An example of "complementary medicine" is use of acupuncture (sticking needles in the body to influence the flow of a supernatural energy), along with using science-based medicine, in the belief that the acupuncture increases the effectiveness or "complements" the science-based medicine.[76] "CAM" is an abbreviation for "complementary and alternative medicine".

The expression "Integrative medicine" (or "integrated medicine") is used in two different ways. One use refers to a belief that medicine based on science can be "integrated" with practices that are not. Another use refers only to a combination of alternative medical treatments with conventional treatments that have some scientific proof of efficacy, in which case it is identical with CAM.[19] "holistic medicine" (or holistic health) is an alternative medicine practice which claim to treat the "whole person" and not just the illness itself.

"Traditional medicine" and "folk medicine" refer to prescientific practices of a culture, not to what is traditionally practiced in cultures where medical science dominates. "Eastern medicine" typically refers to prescientific traditional medicines of Asia. "Western medicine", when referring to modern practice, typically refers to medical science, and not to alternative medicines practiced in the west (Europe and the Americas). "Western medicine", "biomedicine", "mainstream medicine", "medical science", "science-based medicine", "evidence-based medicine", "conventional medicine", "standard medicine", "orthodox medicine", "allopathic medicine", "dominant health system", and "medicine", are sometimes used interchangeably as having the same meaning, when contrasted with alternative medicine, but these terms may have different meanings in some contexts, e.g., some practices in medical science are not supported by rigorous scientific testing so "medical science" is not strictly identical with "science-based medicine", and "standard medical care" may refer to "best practice" when contrasted with other biomedicine that is less used or less recommended.[n 11][79]

Prominent members of the science[27][80] and biomedical science community[21] assert that it is not meaningful to define an alternative medicine that is separate from a conventional medicine, that the expressions "conventional medicine", "alternative medicine", "complementary medicine", "integrative medicine", and "holistic medicine" do not refer to anything at all.[21][27][80][81] Their criticisms of trying to make such artificial definitions include: "There's no such thing as conventional or alternative or complementary or integrative or holistic medicine. There's only medicine that works and medicine that doesn't;"[21][27][80] "By definition, alternative medicine has either not been proved to work, or been proved not to work. You know what they call alternative medicine that's been proved to work? Medicine;"[82] "There cannot be two kinds of medicine conventional and alternative. There is only medicine that has been adequately tested and medicine that has not, medicine that works and medicine that may or may not work. Once a treatment has been tested rigorously, it no longer matters whether it was considered alternative at the outset. If it is found to be reasonably safe and effective, it will be accepted;"[21] and "There is no alternative medicine. There is only scientifically proven, evidence-based medicine supported by solid data or unproven medicine, for which scientific evidence is lacking."[81]

Others in both the biomedical and CAM communities point out that CAM cannot be precisely defined because of the diversity of theories and practices it includes, and because the boundaries between CAM and biomedicine overlap, are porous, and change. The expression "complementary and alternative medicine" (CAM) resists easy definition because the health systems and practices to which it refers are diffuse and its boundaries are poorly defined.[4][n 12] Healthcare practices categorized as alternative may differ in their historical origin, theoretical basis, diagnostic technique, therapeutic practice and in their relationship to the medical mainstream. Some alternative therapies, including traditional Chinese medicine (TCM) and Ayurveda, have antique origins in East or South Asia and are entirely alternative medical systems;[87] others, such as homeopathy and chiropractic, have origins in Europe or the United States and emerged in the eighteenth and nineteenth centuries. Some, such as osteopathy and chiropractic, employ manipulative physical methods of treatment; others, such as meditation and prayer, are based on mind-body interventions. Treatments considered alternative in one location may be considered conventional in another.[90] Thus, chiropractic is not considered alternative in Denmark and likewise osteopathic medicine is no longer thought of as an alternative therapy in the United States.[90]

One common feature of all definitions of alternative medicine is its designation as "other than" conventional medicine. For example, the widely referenced descriptive definition of complementary and alternative medicine devised by the US National Center for Complementary and Integrative Health (NCCIH) of the National Institutes of Health (NIH), states that it is "a group of diverse medical and health care systems, practices, and products that are not generally considered part of conventional medicine."[7] For conventional medical practitioners, it does not necessarily follow that either it or its practitioners would no longer be considered alternative.[n 13]

Some definitions seek to specify alternative medicine in terms of its social and political marginality to mainstream healthcare.[95] This can refer to the lack of support that alternative therapies receive from the medical establishment and related bodies regarding access to research funding, sympathetic coverage in the medical press, or inclusion in the standard medical curriculum.[95] In 1993, the British Medical Association (BMA), one among many professional organizations who have attempted to define alternative medicine, stated that it[n 14] referred to "those forms of treatment which are not widely used by the conventional healthcare professions, and the skills of which are not taught as part of the undergraduate curriculum of conventional medical and paramedical healthcare courses".[69] In a US context, an influential definition coined in 1993 by the Harvard-based physician,[96] David M. Eisenberg,[97] characterized alternative medicine "as interventions neither taught widely in medical schools nor generally available in US hospitals".[98] These descriptive definitions are inadequate in the present-day when some conventional doctors offer alternative medical treatments and CAM introductory courses or modules can be offered as part of standard undergraduate medical training;[99] alternative medicine is taught in more than 50 per cent of US medical schools and increasingly US health insurers are willing to provide reimbursement for CAM therapies. In 1999, 7.7% of US hospitals reported using some form of CAM therapy; this proportion had risen to 37.7% by 2008.[101]

An expert panel at a conference hosted in 1995 by the US Office for Alternative Medicine (OAM),[102][n 15] devised a theoretical definition[102] of alternative medicine as "a broad domain of healing resources... other than those intrinsic to the politically dominant health system of a particular society or culture in a given historical period."[103] This definition has been widely adopted by CAM researchers,[102] cited by official government bodies such as the UK Department of Health,[104] attributed as the definition used by the Cochrane Collaboration,[105] and, with some modification,[dubious discuss] was preferred in the 2005 consensus report of the US Institute of Medicine, Complementary and Alternative Medicine in the United States.[n 4]

The 1995 OAM conference definition, an expansion of Eisenberg's 1993 formulation, is silent regarding questions of the medical effectiveness of alternative therapies.[106] Its proponents hold that it thus avoids relativism about differing forms of medical knowledge and, while it is an essentially political definition, this should not imply that the dominance of mainstream biomedicine is solely due to political forces.[106] According to this definition, alternative and mainstream medicine can only be differentiated with reference to what is "intrinsic to the politically dominant health system of a particular society of culture".[107] However, there is neither a reliable method to distinguish between cultures and subcultures, nor to attribute them as dominant or subordinate, nor any accepted criteria to determine the dominance of a cultural entity.[107] If the culture of a politically dominant healthcare system is held to be equivalent to the perspectives of those charged with the medical management of leading healthcare institutions and programs, the definition fails to recognize the potential for division either within such an elite or between a healthcare elite and the wider population.[107]

Normative definitions distinguish alternative medicine from the biomedical mainstream in its provision of therapies that are unproven, unvalidated or ineffective and support of theories which have no recognized scientific basis. These definitions characterize practices as constituting alternative medicine when, used independently or in place of evidence-based medicine, they are put forward as having the healing effects of medicine, but which are not based on evidence gathered with the scientific method.[7][14][21][74][75][109] Exemplifying this perspective, a 1998 editorial co-authored by Marcia Angell, a former editor of the New England Journal of Medicine, argued that:

This line of division has been subject to criticism, however, as not all forms of standard medical practice have adequately demonstrated evidence of benefit, [n 1][79] and it is also unlikely in most instances that conventional therapies, if proven to be ineffective, would ever be classified as CAM.[102]

Public information websites maintained by the governments of the US and of the UK make a distinction between "alternative medicine" and "complementary medicine", but mention that these two overlap. The National Center for Complementary and Integrative Health (NCCIH) of the National Institutes of Health (NIH) (a part of the US Department of Health and Human Services) states that "alternative medicine" refers to using a non-mainstream approach in place of conventional medicine and that "complementary medicine" generally refers to using a non-mainstream approach together with conventional medicine, and comments that the boundaries between complementary and conventional medicine overlap and change with time.[7]

The National Health Service (NHS) website NHS Choices (owned by the UK Department of Health), adopting the terminology of NCCIH, states that when a treatment is used alongside conventional treatments, to help a patient cope with a health condition, and not as an alternative to conventional treatment, this use of treatments can be called "complementary medicine"; but when a treatment is used instead of conventional medicine, with the intention of treating or curing a health condition, the use can be called "alternative medicine".[111]

Similarly, the public information website maintained by the National Health and Medical Research Council (NHMRC) of the Commonwealth of Australia uses the acronym "CAM" for a wide range of health care practices, therapies, procedures and devices not within the domain of conventional medicine. In the Australian context this is stated to include acupuncture; aromatherapy; chiropractic; homeopathy; massage; meditation and relaxation therapies; naturopathy; osteopathy; reflexology, traditional Chinese medicine; and the use of vitamin supplements.[112]

The Danish National Board of Health's "Council for Alternative Medicine" (Sundhedsstyrelsens Rd for Alternativ Behandling (SRAB)), an independent institution under the National Board of Health (Danish: Sundhedsstyrelsen), uses the term "alternative medicine" for:

In General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, published in 2000 by the World Health Organization (WHO), complementary and alternative medicine were defined as a broad set of health care practices that are not part of that country's own tradition and are not integrated into the dominant health care system.[114] Some herbal therapies are mainstream in Europe but are alternative in the US.[116]

The history of alternative medicine may refer to the history of a group of diverse medical practices that were collectively promoted as "alternative medicine" beginning in the 1970s, to the collection of individual histories of members of that group, or to the history of western medical practices that were labeled "irregular practices" by the western medical establishment.[1][117][118][119][120] It includes the histories of complementary medicine and of integrative medicine. Before the 1970s, western practitioners that were not part of the increasingly science-based medical establishment were referred to "irregular practitioners", and were dismissed by the medical establishment as unscientific and as practicing quackery.[117][118] Until the 1970's, irregular practice became increasingly marginalized as quackery and fraud, as western medicine increasingly incorporated scientific methods and discoveries, and had a corresponding increase in success of its treatments.[119] In the 1970s, irregular practices were grouped with traditional practices of nonwestern cultures and with other unproven or disproven practices that were not part of biomedicine, with the entire group collectively marketed and promoted under the single expression "alternative medicine".[1][117][118][119][121]

Use of alternative medicine in the west began to rise following the counterculture movement of the 1960s, as part of the rising new age movement of the 1970s.[1][122][123] This was due to misleading mass marketing of "alternative medicine" being an effective "alternative" to biomedicine, changing social attitudes about not using chemicals and challenging the establishment and authority of any kind, sensitivity to giving equal measure to beliefs and practices of other cultures (cultural relativism), and growing frustration and desperation by patients about limitations and side effects of science-based medicine.[1][118][119][120][121][123][124] At the same time, in 1975, the American Medical Association, which played the central role in fighting quackery in the United States, abolished its quackery committee and closed down its Department of Investigation.[117]:xxi[124] By the early to mid 1970s the expression "alternative medicine" came into widespread use, and the expression became mass marketed as a collection of "natural" and effective treatment "alternatives" to science-based biomedicine.[1][124][125][126] By 1983, mass marketing of "alternative medicine" was so pervasive that the British Medical Journal (BMJ) pointed to "an apparently endless stream of books, articles, and radio and television programmes urge on the public the virtues of (alternative medicine) treatments ranging from meditation to drilling a hole in the skull to let in more oxygen".[124] In this 1983 article, the BMJ wrote, "one of the few growth industries in contemporary Britain is alternative medicine", noting that by 1983, "33% of patients with rheumatoid arthritis and 39% of those with backache admitted to having consulted an alternative practitioner".[124]

By about 1990, the American alternative medicine industry had grown to a $27 Billion per year, with polls showing 30% of Americans were using it.[123][127] Moreover, polls showed that Americans made more visits for alternative therapies than the total number of visits to primary care doctors, and American out-of-pocket spending (non-insurance spending) on alternative medicine was about equal to spending on biomedical doctors.[117]:172 In 1991, Time magazine ran a cover story, "The New Age of Alternative Medicine: Why New Age Medicine Is Catching On".[123][127] In 1993, the New England Journal of Medicine reported one in three Americans as using alternative medicine.[123] In 1993, the Public Broadcasting System ran a Bill Moyers special, Healing and the Mind, with Moyers commenting that "...people by the tens of millions are using alternative medicine. If established medicine does not understand that, they are going to lose their clients."[123]

Another explosive growth began in the 1990s, when senior level political figures began promoting alternative medicine, investing large sums of government medical research funds into testing alternative medicine, including testing of scientifically implausible treatments, and relaxing government regulation of alternative medicine products as compared to biomedical products.[1][117]:xxi[118][119][120][121][128][129] Beginning with a 1991 appropriation of $2 million for funding research of alternative medicine research, federal spending grew to a cumulative total of about $2.5 billion by 2009, with 50% of Americans using alternative medicine by 2013.[11][130]

In 1991, pointing to a need for testing because of the widespread use of alternative medicine without authoritative information on its efficacy, United States Senator Tom Harkin used $2 million of his discretionary funds to create the Office for the Study of Unconventional Medical Practices (OSUMP), later renamed to be the Office of Alternative Medicine (OAM).[117]:170[131][132] The OAM was created to be within the National Institute of Health (NIH), the scientifically prestigious primary agency of the United States government responsible for biomedical and health-related research.[117]:170[131][132] The mandate was to investigate, evaluate, and validate effective alternative medicine treatments, and alert the public as the results of testing its efficacy.[127][131][132][133]

Sen. Harkin had become convinced his allergies were cured by taking bee pollen pills, and was urged to make the spending by two of his influential constituents.[127][131][132] Bedell, a longtime friend of Sen. Harkin, was a former member of the United States House of Representatives who believed that alternative medicine had twice cured him of diseases after mainstream medicine had failed, claiming that cow's milk colostrum cured his Lyme disease, and an herbal derivative from camphor had prevented post surgical recurrence of his prostate cancer.[117][127] Wiewel was a promoter of unproven cancer treatments involving a mixture of blood sera that the Food and Drug Administration had banned from being imported.[127] Both Bedell and Wiewel became members of the advisory panel for the OAM. The company that sold the bee pollen was later fined by the Federal Trade Commission for making false health claims about their bee-pollen products reversing the aging process, curing allergies, and helping with weight loss.[134]

In 1993, Britain's Prince Charles, who claimed that homeopathy and other alternative medicine was an effective alternative to biomedicine, established the Foundation for Integrated Health (FIH), as a charity to explore "how safe, proven complementary therapies can work in conjunction with mainstream medicine".[135] The FIH received government funding through grants from Britain's Department of Health.[135]

In 1994, Sen. Harkin (D) and Senator Orrin Hatch (R) introduced the Dietary Supplement Health and Education Act (DSHEA).[136][137] The act reduced authority of the FDA to monitor products sold as "natural" treatments.[136] Labeling standards were reduced to allow health claims for supplements based only on unconfirmed preliminary studies that were not subjected to scientific peer review, and the act made it more difficult for the FDA to promptly seize products or demand proof of safety where there was evidence of a product being dangerous.[137] The Act became known as the "The 1993 Snake Oil Protection Act" following a New York Times editorial under that name.[136]

Senator Harkin complained about the "unbendable rules of randomized clinical trials", citing his use of bee pollen to treat his allergies, which he claimed to be effective even though it was biologically implausible and efficacy was not established using scientific methods.[131][138] Sen. Harkin asserted that claims for alternative medicine efficacy be allowed not only without conventional scientific testing, even when they are biologically implausible, "It is not necessary for the scientific community to understand the process before the American public can benefit from these therapies."[136] Following passage of the act, sales rose from about $4 billion in 1994, to $20 billion by the end of 2000, at the same time as evidence of their lack of efficacy or harmful effects grew.[136] Senator Harkin came into open public conflict with the first OAM Director Joseph M. Jacobs and OAM board members from the scientific and biomedical community.[132] Jacobs' insistence on rigorous scientific methodology caused friction with Senator Harkin.[131][138][139] Increasing political resistance to the use of scientific methodology was publicly criticized by Dr. Jacobs and another OAM board member complained that "nonsense has trickled down to every aspect of this office".[131][138] In 1994, Senator Harkin appeared on television with cancer patients who blamed Dr. Jacobs for blocking their access to untested cancer treatment, leading Jacobs to resign in frustration.[131][138]

In 1995, Wayne Jonas, a promoter of homeopathy and political ally of Senator Harkin, became the director of the OAM, and continued in that role until 1999.[140] In 1997, the NCCAM budget was increased from $12 million to $20 million annually.[141] From 1990 to 1997, use of alternative medicine in the US increased by 25%, with a corresponding 50% increase in expenditures.[142] The OAM drew increasing criticism from eminent members of the scientific community with letters to the Senate Appropriations Committee when discussion of renewal of funding OAM came up.[117]:175 Nobel laureate Paul Berg wrote that prestigious NIH should not be degraded to act as a cover for quackery, calling the OAM "an embarrassment to serious scientists."[117]:175[141] The president of the American Physical Society wrote complaining that the government was spending money on testing products and practices that "violate basic laws of physics and more clearly resemble witchcraft".[117]:175[141] In 1998, the President of the North Carolina Medical Association publicly called for shutting down the OAM.[143]

In 1998, NIH director and Nobel laureate Harold Varmus came into conflict with Senator Harkin by pushing to have more NIH control of alternative medicine research.[144] The NIH Director placed the OAM under more strict scientific NIH control.[141][144] Senator Harkin responded by elevating OAM into an independent NIH "center", just short of being its own "institute", and renamed to be the National Center for Complementary and Alternative Medicine (NCCAM). NCCAM had a mandate to promote a more rigorous and scientific approach to the study of alternative medicine, research training and career development, outreach, and "integration". In 1999, the NCCAM budget was increased from $20 million to $50 million.[143][144] The United States Congress approved the appropriations without dissent. In 2000, the budget was increased to about $68 million, in 2001 to $90 million, in 2002 to $104 million, and in 2003, to $113 million.[143]

In 2004, modifications of the European Parliament's 2001 Directive 2001/83/EC, regulating all medicine products, were made with the expectation of influencing development of the European market for alternative medicine products.[145] Regulation of alternative medicine in Europe was loosened with "a simplified registration procedure" for traditional herbal medicinal products.[145][146] Plausible "efficacy" for traditional medicine was redefined to be based on long term popularity and testimonials ("the pharmacological effects or efficacy of the medicinal product are plausible on the basis of long-standing use and experience."), without scientific testing.[145][146] The Committee on Herbal Medicinal Products (HMPC) was created within the European Medicines Agency in London (EMEA). A special working group was established for homeopathic remedies under the Heads of Medicines Agencies.[145]

Through 2004, alternative medicine that was traditional to Germany continued to be a regular part of the health care system, including homeopathy and anthroposophic medicine.[145] The German Medicines Act mandated that science-based medical authorities consider the "particular characteristics" of complementary and alternative medicines.[145] By 2004, homeopathy had grown to be the most used alternative therapy in France, growing from 16% of the population using homeopathic medicine in 1982, to 29% by 1987, 36% percent by 1992, and 62% of French mothers using homeopathic medicines by 2004, with 94.5% of French pharmacists advising pregnant women to use homeopathic remedies.[147] As of 2004[update], 100 million people in India depended solely on traditional German homeopathic remedies for their medical care.[148] As of 2010[update], homeopathic remedies continued to be the leading alternative treatment used by European physicians.[147] By 2005, sales of homeopathic remedies and anthroposophical medicine had grown to $930 million Euros, a 60% increase from 1995.[147][149]

In 2008, London's The Times published a letter from Edzard Ernst that asked the FIH to recall two guides promoting alternative medicine, saying: "the majority of alternative therapies appear to be clinically ineffective, and many are downright dangerous." In 2010, Brittan's FIH closed after allegations of fraud and money laundering led to arrests of its officials.[135]

In 2009, after a history of 17 years of government testing and spending of nearly $2.5 billion on research had produced almost no clearly proven efficacy of alternative therapies, Senator Harkin complained, "One of the purposes of this center was to investigate and validate alternative approaches. Quite frankly, I must say publicly that it has fallen short. It think quite frankly that in this center and in the office previously before it, most of its focus has been on disproving things rather than seeking out and approving."[144][150][151] Members of the scientific community criticized this comment as showing Senator Harkin did not understand the basics of scientific inquiry, which tests hypotheses, but never intentionally attempts to "validate approaches".[144] Members of the scientific and biomedical communities complained that after a history of 17 years of being tested, at a cost of over $2.5 Billion on testing scientifically and biologically implausible practices, almost no alternative therapy showed clear efficacy.[11] In 2009, the NCCAM's budget was increased to about $122 million.[144] Overall NIH funding for CAM research increased to $300 Million by 2009.[144] By 2009, Americans were spending $34 Billion annually on CAM.[152]

Since 2009, according to Art. 118a of the Swiss Federal Constitution, the Swiss Confederation and the Cantons of Switzerland shall within the scope of their powers ensure that consideration is given to complementary medicine.[153]

In 2012, the Journal of the American Medical Association (JAMA) published a criticism that study after study had been funded by NCCAM, but "failed to prove that complementary or alternative therapies are anything more than placebos".[154] The JAMA criticism pointed to large wasting of research money on testing scientifically implausible treatments, citing "NCCAM officials spending $374,000 to find that inhaling lemon and lavender scents does not promote wound healing; $750,000 to find that prayer does not cure AIDS or hasten recovery from breast-reconstruction surgery; $390,000 to find that ancient Indian remedies do not control type 2 diabetes; $700,000 to find that magnets do not treat arthritis, carpal tunnel syndrome, or migraine headaches; and $406,000 to find that coffee enemas do not cure pancreatic cancer."[154] It was pointed out that negative results from testing were generally ignored by the public, that people continue to "believe what they want to believe, arguing that it does not matter what the data show: They know what works for them".[154] Continued increasing use of CAM products was also blamed on the lack of FDA ability to regulate alternative products, where negative studies do not result in FDA warnings or FDA-mandated changes on labeling, whereby few consumers are aware that many claims of many supplements were found not to have not to be supported.[154]

By 2013, 50% of Americans were using CAM.[130] As of 2013[update], CAM medicinal products in Europe continued to be exempted from documented efficacy standards required of other medicinal products.[155]

In 2014 the NCCAM was renamed to the National Center for Complementary and Integrative Health (NCCIH) with a new charter requiring that 12 of the 18 council members shall be selected with a preference to selecting leading representatives of complementary and alternative medicine, 9 of the members must be licensed practitioners of alternative medicine, 6 members must be general public leaders in the fields of public policy, law, health policy, economics, and management, and 3 members must represent the interests of individual consumers of complementary and alternative medicine.[156]

Much of what is now categorized as alternative medicine was developed as independent, complete medical systems. These were developed long before biomedicine and use of scientific methods. Each system was developed in relatively isolated regions of the world where there was little or no medical contact with pre-scientific western medicine, or with each other's systems. Examples are traditional Chinese medicine and the Ayurvedic medicine of India.

Other alternative medicine practices, such as homeopathy, were developed in western Europe and in opposition to western medicine, at a time when western medicine was based on unscientific theories that were dogmatically imposed by western religious authorities. Homeopathy was developed prior to discovery of the basic principles of chemistry, which proved homeopathic remedies contained nothing but water. But homeopathy, with its remedies made of water, was harmless compared to the unscientific and dangerous orthodox western medicine practiced at that time, which included use of toxins and draining of blood, often resulting in permanent disfigurement or death.[118]

Other alternative practices such as chiropractic and osteopathic manipulative medicine were developed in the United States at a time that western medicine was beginning to incorporate scientific methods and theories, but the biomedical model was not yet totally dominant. Practices such as chiropractic and osteopathic, each considered to be irregular practices by the western medical establishment, also opposed each other, both rhetorically and politically with licensing legislation. Osteopathic practitioners added the courses and training of biomedicine to their licensing, and licensed Doctor of Osteopathic Medicine holders began diminishing use of the unscientific origins of the field. Without the original nonscientific practices and theories, osteopathic medicine is now considered the same as biomedicine.

Further information: Rise of modern medicine

Until the 1970s, western practitioners that were not part of the medical establishment were referred to "irregular practitioners", and were dismissed by the medical establishment as unscientific, as practicing quackery.[118] Irregular practice became increasingly marginalized as quackery and fraud, as western medicine increasingly incorporated scientific methods and discoveries, and had a corresponding increase in success of its treatments.

Dating from the 1970s, medical professionals, sociologists, anthropologists and other commentators noted the increasing visibility of a wide variety of health practices that had neither derived directly from nor been verified by biomedical science.[157] Since that time, those who have analyzed this trend have deliberated over the most apt language with which to describe this emergent health field.[157] A variety of terms have been used, including heterodox, irregular, fringe and alternative medicine while others, particularly medical commentators, have been satisfied to label them as instances of quackery.[157] The most persistent term has been alternative medicine but its use is problematic as it assumes a value-laden dichotomy between a medical fringe, implicitly of borderline acceptability at best, and a privileged medical orthodoxy, associated with validated medico-scientific norms.[158] The use of the category of alternative medicine has also been criticized as it cannot be studied as an independent entity but must be understood in terms of a regionally and temporally specific medical orthodoxy.[159] Its use can also be misleading as it may erroneously imply that a real medical alternative exists.[160] As with near-synonymous expressions, such as unorthodox, complementary, marginal, or quackery, these linguistic devices have served, in the context of processes of professionalisation and market competition, to establish the authority of official medicine and police the boundary between it and its unconventional rivals.[158]

An early instance of the influence of this modern, or western, scientific medicine outside Europe and North America is Peking Union Medical College.[161][n 16][n 17]

From a historical perspective, the emergence of alternative medicine, if not the term itself, is typically dated to the 19th century.[162] This is despite the fact that there are variants of Western non-conventional medicine that arose in the late-eighteenth century or earlier and some non-Western medical traditions, currently considered alternative in the West and elsewhere, which boast extended historical pedigrees.[158] Alternative medical systems, however, can only be said to exist when there is an identifiable, regularized and authoritative standard medical practice, such as arose in the West during the nineteenth-century, to which they can function as an alternative.

During the late eighteenth and nineteenth centuries regular and irregular medical practitioners became more clearly differentiated throughout much of Europe and,[164] as the nineteenth century progressed, most Western states converged in the creation of legally delimited and semi-protected medical markets.[165] It is at this point that an "official" medicine, created in cooperation with the state and employing a scientific rhetoric of legitimacy, emerges as a recognizable entity and that the concept of alternative medicine as a historical category becomes tenable.[166]

As part of this process, professional adherents of mainstream medicine in countries such as Germany, France, and Britain increasingly invoked the scientific basis of their discipline as a means of engendering internal professional unity and of external differentiation in the face of sustained market competition from homeopaths, naturopaths, mesmerists and other nonconventional medical practitioners, finally achieving a degree of imperfect dominance through alliance with the state and the passage of regulatory legislation.[158][160] In the US the Johns Hopkins University School of Medicine, based in Baltimore, Maryland, opened in 1893, with William H. Welch and William Osler among the founding physicians, and was the first medical school devoted to teaching "German scientific medicine".[167]

Buttressed by the increased authority arising from significant advances in the medical sciences of the late 19th century onwardsincluding the development and application of the germ theory of disease by the chemist Louis Pasteur and the surgeon Joseph Lister, of microbiology co-founded by Robert Koch (in 1885 appointed professor of hygiene at the University of Berlin), and of the use of X-rays (Rntgen rays)the 1910 Flexner Report called upon American medical schools to follow the model set by the Johns Hopkins School of Medicine and adhere to mainstream science in their teaching and research. This was in a belief, mentioned in the Report's introduction, that the preliminary and professional training then prevailing in medical schools should be reformed in view of the new means for diagnosing and combating disease being made available to physicians and surgeons by the sciences on which medicine depended.[n 18][169]

Among putative medical practices available at the time which later became known as "alternative medicine" were homeopathy (founded in Germany in the early 19c.) and chiropractic (founded in North America in the late 19c.). These conflicted in principle with the developments in medical science upon which the Flexner reforms were based, and they have not become compatible with further advances of medical science such as listed in Timeline of medicine and medical technology, 19001999 and 2000present, nor have Ayurveda, acupuncture or other kinds of alternative medicine.[citation needed]

At the same time "Tropical medicine" was being developed as a specialist branch of western medicine in research establishments such as Liverpool School of Tropical Medicine founded in 1898 by Alfred Lewis Jones, London School of Hygiene & Tropical Medicine, founded in 1899 by Patrick Manson and Tulane University School of Public Health and Tropical Medicine, instituted in 1912. A distinction was being made between western scientific medicine and indigenous systems. An example is given by an official report about indigenous systems of medicine in India, including Ayurveda, submitted by Mohammad Usman of Madras and others in 1923. This stated that the first question the Committee considered was "to decide whether the indigenous systems of medicine were scientific or not".[170][171]

By the later twentieth century the term 'alternative medicine' entered public discourse,[n 19][174] but it was not always being used with the same meaning by all parties. Arnold S. Relman remarked in 1998 that in the best kind of medical practice, all proposed treatments must be tested objectively, and that in the end there will only be treatments that pass and those that do not, those that are proven worthwhile and those that are not. He asked 'Can there be any reasonable "alternative"?'[28] But also in 1998 the then Surgeon General of the United States, David Satcher,[175] issued public information about eight common alternative treatments (including acupuncture, holistic and massage), together with information about common diseases and conditions, on nutrition, diet, and lifestyle changes, and about helping consumers to decipher fraud and quackery, and to find healthcare centers and doctors who practiced alternative medicine.[176]

By 1990, approximately 60 million Americans had used one or more complementary or alternative therapies to address health issues, according to a nationwide survey in the US published in 1993 by David Eisenberg.[177] A study published in the November 11, 1998 issue of the Journal of the American Medical Association reported that 42% of Americans had used complementary and alternative therapies, up from 34% in 1990.[142] However, despite the growth in patient demand for complementary medicine, most of the early alternative/complementary medical centers failed.[178]

Mainly as a result of reforms following the Flexner Report of 1910[179]medical education in established medical schools in the US has generally not included alternative medicine as a teaching topic.[n 20] Typically, their teaching is based on current practice and scientific knowledge about: anatomy, physiology, histology, embryology, neuroanatomy, pathology, pharmacology, microbiology and immunology.[181] Medical schools' teaching includes such topics as doctor-patient communication, ethics, the art of medicine,[182] and engaging in complex clinical reasoning (medical decision-making).[183] Writing in 2002, Snyderman and Weil remarked that by the early twentieth century the Flexner model had helped to create the 20th-century academic health center in which education, research and practice were inseparable. While this had much improved medical practice by defining with increasing certainty the pathophysiological basis of disease, a single-minded focus on the pathophysiological had diverted much of mainstream American medicine from clinical conditions which were not well understood in mechanistic terms and were not effectively treated by conventional therapies.[184]

By 2001 some form of CAM training was being offered by at least 75 out of 125 medical schools in the US.[185] Exceptionally, the School of Medicine of the University of Maryland, Baltimore includes a research institute for integrative medicine (a member entity of the Cochrane Collaboration).[186][187] Medical schools are responsible for conferring medical degrees, but a physician typically may not legally practice medicine until licensed by the local government authority. Licensed physicians in the US who have attended one of the established medical schools there have usually graduated Doctor of Medicine (MD).[188] All states require that applicants for MD licensure be graduates of an approved medical school and complete the United States Medical Licensing Exam (USMLE).[188]

The British Medical Association, in its publication Complementary Medicine, New Approach to Good Practice (1993), gave as a working definition of non-conventional therapies (including acupuncture, chiropractic and homeopathy): "those forms of treatment which are not widely used by the orthodox health-care professions, and the skills of which are not part of the undergraduate curriculum of orthodox medical and paramedical health-care courses". By 2000 some medical schools in the UK were offering CAM familiarisation courses to undergraduate medical students while some were also offering modules specifically on CAM.[190]

The Cochrane Collaboration Complementary Medicine Field explains its "Scope and Topics" by giving a broad and general definition for complementary medicine as including practices and ideas which are outside the domain of conventional medicine in several countries and defined by its users as preventing or treating illness, or promoting health and well being, and which complement mainstream medicine in three ways: by contributing to a common whole, by satisfying a demand not met by conventional practices, and by diversifying the conceptual framework of medicine.[191]

Proponents of an evidence-base for medicine[n 21][193][194][195][196] such as the Cochrane Collaboration (founded in 1993 and from 2011 providing input for WHO resolutions) take a position that all systematic reviews of treatments, whether "mainstream" or "alternative", ought to be held to the current standards of scientific method.[187] In a study titled Development and classification of an operational definition of complementary and alternative medicine for the Cochrane Collaboration (2011) it was proposed that indicators that a therapy is accepted include government licensing of practitioners, coverage by health insurance, statements of approval by government agencies, and recommendation as part of a practice guideline; and that if something is currently a standard, accepted therapy, then it is not likely to be widely considered as CAM.[102]

That alternative medicine has been on the rise "in countries where Western science and scientific method generally are accepted as the major foundations for healthcare, and 'evidence-based' practice is the dominant paradigm" was described as an "enigma" in the Medical Journal of Australia.[197]

Critics in the US say the expression is deceptive because it implies there is an effective alternative to science-based medicine, and that complementary is deceptive because the word implies that the treatment increases the effectiveness of (complements) science-based medicine, while alternative medicines which have been tested nearly always have no measurable positive effect compared to a placebo.[1][198][199][200]

Some opponents, focused upon health fraud, misinformation, and quackery as public health problems in the US, are highly critical of alternative medicine, notably Wallace Sampson and Paul Kurtz founders of Scientific Review of Alternative Medicine and Stephen Barrett, co-founder of The National Council Against Health Fraud and webmaster of Quackwatch.[201] Grounds for opposing alternative medicine which have been stated in the US and elsewhere are:

Paul Offit has proposed four ways that "alternative medicine becomes quackery":[80]

A United States government agency, the National Center on Complementary and Integrative Health (NCCIH), has created its own classification system for branches of complementary and alternative medicine. It classifies complementary and alternative therapies into five major groups, which have some overlap and two types of energy medicine are distinguished: one, "Veritable" involving scientifically observable energy, including magnet therapy, colorpuncture and light therapy; the other "Putative" which invoke physically undetectable or unverifiable energy.[210]

Alternative medicine practices and beliefs are diverse in their foundations and methodologies. The wide range of treatments and practices referred to as alternative medicine includes some stemming from nineteenth century North America, such as chiropractic and naturopathy, others, mentioned by Jtte, that originated in eighteenth- and nineteenth-century Germany, such as homeopathy and hydropathy,[160] and some that have originated in China or India, while African, Caribbean, Pacific Island, Native American, and other regional cultures have traditional medical systems as diverse as their diversity of cultures.[7]

Examples of CAM as a broader term for unorthodox treatment and diagnosis of illnesses, disease, infections, etc.,[211] include yoga, acupuncture, aromatherapy, chiropractic, herbalism, homeopathy, hypnotherapy, massage, osteopathy, reflexology, relaxation therapies, spiritual healing and tai chi.[211] CAM differs from conventional medicine. It is normally private medicine and not covered by health insurance.[211] It is paid out of pocket by the patient and is an expensive treatment.[211] CAM tends to be a treatment for upper class or more educated people.[142]

The NCCIH classification system is -

Alternative therapies based on electricity or magnetism use verifiable electromagnetic fields, such as pulsed fields, alternating-current, or direct-current fields in an unconventional manner rather than claiming the existence of imponderable or supernatural energies.[7]

Substance based practices use substances found in nature such as herbs, foods, non-vitamin supplements and megavitamins, and minerals, and includes traditional herbal remedies with herbs specific to regions in which the cultural practices arose.[7] Nonvitamin supplements include fish oil, Omega-3 fatty acid, glucosamine, echinacea, flaxseed oil or pills, and ginseng, when used under a claim to have healing effects.[61]

Mind-body interventions, working under the premise that the mind can affect "bodily functions and symptoms",[7] include healing claims made in hypnotherapy,[212] and in guided imagery, meditation, progressive relaxation, qi gong, tai chi and yoga.[7] Meditation practices including mantra meditation, mindfulness meditation, yoga, tai chi, and qi gong have many uncertainties. According to an AHRQ review, the available evidence on meditation practices through September 2005 is of poor methodological quality and definite conclusions on the effects of meditation in healthcare cannot be made using existing research.[213][214]

Naturopathy is based on a belief in vitalism, which posits that a special energy called vital energy or vital force guides bodily processes such as metabolism, reproduction, growth, and adaptation.[36] The term was coined in 1895[215] by John Scheel and popularized by Benedict Lust, the "father of U.S. naturopathy".[216] Today, naturopathy is primarily practiced in the United States and Canada.[217] Naturopaths in unregulated jurisdictions may use the Naturopathic Doctor designation or other titles regardless of level of education.[218]

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Integrative Medicine – 9781437717938 | US Elsevier Health …

August 4th, 2016 9:40 am

Part 1: Integrative Medicine

1. The Philosophy of Integrative Medicine

2. Creating Optimal Healing Environments

3. The Healing Encounter

Part 2: Integrative Approach to Disease

Section 1: Affective Disorders

4. Depression

5. Anxiety

6. Attention Deficit Hyperactivity Disorder (ADHD)

7. Autism Spectrum Disorder

8. Insomnia

Section 2: Neurology

9. Alzheimer's Disease

10. Headache

11. Peripheral Neuropathy

12. Multiple Sclerosis

13. Parkinson's Disease

Section 3: Infectious Disease

14. Otitis Media

15. Chronic Sinusitis

16. Viral Upper Respiratory Infection

17. HIV Disease and AIDS

18. Herpes Simplex Virus

19. Chronic Hepatitis

20. Urinary Tract Infection

21. Recurrent Yeast Infections

22. Lyme Disease

Section 4: Cardiovascular Disease

23. Hypertension

24. Heart Failure

25. Coronary Artery Disease

26. Peripheral Vascular Disease

27. Arrhythmias

Section 5: Allergy/Intolerance

28. Asthma

29. The Allergic Patient

30. Multiple Chemical Sensitivity Syndrome

Section 6: Metabolic/Endocrine Disorders

31. Insulin Resistance and the Metabolic Syndrome

32. Type 2 Diabetes

33. Hypothyroidism

34. Hormone Replacement in Men

35. Hormone Replacement in Women

36. Polycystic Ovarian Syndrome

37. Osteoporosis

38. An Integrative Approach to Obesity

39. Dyslipidemias

Section 7: Gastrointestinal Disorders

40. Irritable Bowel Syndrome

41. Gastroesophageal Reflux Disease

42. Peptic Ulcer Disease

43. Cholelithiasis

44. Recurring Abdominal Pain in Pediatrics

45. Constipation

Section 8: Autoimmune Disorders

46. Fibromyalgia

47. Chronic Fatigue Spectrum

48. Rheumatoid Arthritis

49. Inflammatory Bowel Disease

Section 9: Obstetrics/Gynecology

50. Post Dates Pregnancy

51. Labor Pain Management

52. Nausea and Vomiting in Pregnancy

53. Premenstrual Syndrome

54. Dysmenorrhea

55. Uterine Fibroids (Leiomyomata)

56. Vaginal Dryness

Section 10: Urology

57. Benign Prostatic Hyperplasia

58. Urolithiasis

59. Chronic Prostatitis

60. Erectile Dysfunction

Section 11: Musculoskeletal Disorders

61. Osteoarthritis

62. Myofascial Pain Syndrome

63. Chronic Low Back Pain

64. Neck Pain

65. Gout

66. Carpal Tunnel Syndrome

67. Epicondylosis

Section 12: Dermatology

68. Atopic Dermatitis

69. Psoriasis

70. Urticaria

71. Recurrent Aphthous Ulceration

72. Seborrheic Dermatitis

73. Acne Vulgaris and Acne Rosacea

74. Human Papillomavirus and Warts

Section 13: Cancer

75. Breast Cancer

76. Lung Cancer

77. Prostate Cancer

78. Colorectal Cancer

79. Skin Cancer

80. End-of-Life Care

Section 14: Substance Abuse

81. Alcoholism and Substance Abuse

Section 15: Ophthalmology

82. Cataracts

83. Age-Related Macular Degeneration

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Careers in Biotechnology – List of various options

August 4th, 2016 9:40 am

Various biotechnology careers include forensic DNA analyst, scientist, clinical research associate job, laboratory assistant, microbiologist, greenhouse and field technician, bioinformatics specialist, animal caretaker and many more.

Biotechnology is combining knowledge about life and living organisms with modern technology to create new systems, devices, materials, foodthat could improve human life and help preserve environment. Most biotechnology products are associated with agriculture, food industry and medicine, and logically - careers in those fields are most popular.

Average Salary (per month) for a Green House and Field Technician may range from: US $2500-3000 In India, salaries may range between: INR 15,000-30,000 (or more, depending upon the experience)

This position is usually associated with crime laboratories where DNA analysis is performed to solve legal issues. Urine, saliva, blood, semen, hairthose are the samples that could be used for DNA analysis. After sample collection, DNA is extracted and analyzed using couple methods (PCR, electrophoresis). Final results are further compared with the already known DNA profiles. Methodology is strict: properly collected and stored evidence, documentation on technical laboratory details and well written final reports are essential for successful prosecution. Depending on the laboratory size, employees could be more or less specialized.

Average Salary (per month) for a Clinical Research Associate may range from: US $4500-5000 In India, salaries may range between: INR 20,000-25,000 (or more, depending upon the experience and repute of the firm)

Average Salary (per month) for a Bioinformatics Specialist may range from: US $5000-6000 In India, salaries may range between: INR 30,000-45,000 (or more, depending upon the experience and repute of the firm)

Animal caretaker is nurturing animals used in biotech research. List of species used is long: all the way from mice and rats to cows and chimps. Water and food supplies, cage cleaning, animal health monitoring, relocation, milking, artificial insemination a lot of duties need to be performed and not all tasks are representative. If you put aside that animals have specific odor (and different bodily fluids and excretions) keep in mind that watching animal suffer during experiments isnt easy or nice thing to do. Average Salary (per month) for an Animal Caretaker may range from: US $1000-1200 In India, salaries may range between: INR 10,000-15,000

Average Salary (per month) for a Production Engineer may range from: US $6000-7000 In India, salaries may range between: INR 30,000-50,000 (depending upon experience, institute of study and company as well)

Average Salary (per month) for a QA engineer may range from: US $5000-6000 In India, salaries may range between: INR 25,000-30,000 (depending upon experience, institute of study and company as well)

Average Salary (per month) for a Consultant may range from: US $6000-8000 In India, salaries may range between: INR 30,000-1,00,000 (depending upon experience, institute of study and company as well)

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Diabetes: Symptoms, Causes and Treatments – Health News

August 4th, 2016 9:40 am

knowledge center home diabetes what is diabetes?

Diabetes, often referred to by doctors as diabetes mellitus, describes a group of metabolic diseases in which the person has high blood glucose (blood sugar), either because insulin production is inadequate, or because the body's cells do not respond properly to insulin, or both. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia).

Fast facts on diabetes

Here are some key points about diabetes. More detail and supporting information is in the main article.

This information hub offers detailed but easy-to-follow information about diabetes. Should you be interested in the latest scientific research on diabetes, please see our diabetes news section.

There are three types of diabetes:

The body does not produce insulin. Some people may refer to this type as insulin-dependent diabetes, juvenile diabetes, or early-onset diabetes. People usually develop type 1 diabetes before their 40th year, often in early adulthood or teenage years.

Type 1 diabetes is nowhere near as common as type 2 diabetes. Approximately 10% of all diabetes cases are type 1.

Patients with type 1 diabetes will need to take insulin injections for the rest of their life. They must also ensure proper blood-glucose levels by carrying out regular blood tests and following a special diet.

Between 2001 and 2009, the prevalence of type 1 diabetes among the under 20s in the USA rose 23%, according to SEARCH for Diabetes in Youth data issued by the CDC (Centers for Disease Control and Prevention). (Link to article)

More information on type 1 diabetes is available in our type 1 diabetes page.

The body does not produce enough insulin for proper function, or the cells in the body do not react to insulin (insulin resistance).

Approximately 90% of all cases of diabetes worldwide are type 2.

Some people may be able to control their type 2 diabetes symptoms by losing weight, following a healthy diet, doing plenty of exercise, and monitoring their blood glucose levels. However, type 2 diabetes is typically a progressive disease - it gradually gets worse - and the patient will probably end up have to take insulin, usually in tablet form.

Overweight and obese people have a much higher risk of developing type 2 diabetes compared to those with a healthy body weight. People with a lot of visceral fat, also known as central obesity, belly fat, or abdominal obesity, are especially at risk. Being overweight/obese causes the body to release chemicals that can destabilize the body's cardiovascular and metabolic systems.

Being overweight, physically inactive and eating the wrong foods all contribute to our risk of developing type 2 diabetes. Drinking just one can of (non-diet) soda per day can raise our risk of developing type 2 diabetes by 22%, researchers from Imperial College London reported in the journal Diabetologia. The scientists believe that the impact of sugary soft drinks on diabetes risk may be a direct one, rather than simply an influence on body weight.

The risk of developing type 2 diabetes is also greater as we get older. Experts are not completely sure why, but say that as we age we tend to put on weight and become less physically active. Those with a close relative who had/had type 2 diabetes, people of Middle Eastern, African, or South Asian descent also have a higher risk of developing the disease.

Men whose testosterone levels are low have been found to have a higher risk of developing type 2 diabetes. Researchers from the University of Edinburgh, Scotland, say that low testosterone levels are linked to insulin resistance. (Link to article)

For more information on how type 1 and type 2 diabetes compare, see our article: the difference between type 1 and type 2 diabetes.

More information on type 1 diabetes is available in our type 2 diabetes page.

This type affects females during pregnancy. Some women have very high levels of glucose in their blood, and their bodies are unable to produce enough insulin to transport all of the glucose into their cells, resulting in progressively rising levels of glucose.

Diagnosis of gestational diabetes is made during pregnancy.

The majority of gestational diabetes patients can control their diabetes with exercise and diet. Between 10% to 20% of them will need to take some kind of blood-glucose-controlling medications. Undiagnosed or uncontrolled gestational diabetes can raise the risk of complications during childbirth. The baby may be bigger than he/she should be.

Scientists from the National Institutes of Health and Harvard University found that women whose diets before becoming pregnant were high in animal fat and cholesterol had a higher risk for gestational diabetes, compared to their counterparts whose diets were low in cholesterol and animal fats. (Link to article)

See the next page of our article for a full list of possible diabetes symptoms.

The vast majority of patients with type 2 diabetes initially had prediabetes. Their blood glucose levels where higher than normal, but not high enough to merit a diabetes diagnosis. The cells in the body are becoming resistant to insulin.

Studies have indicated that even at the prediabetes stage, some damage to the circulatory system and the heart may already have occurred.

Diabetes (diabetes mellitus) is classed as a metabolism disorder. Metabolism refers to the way our bodies use digested food for energy and growth. Most of what we eat is broken down into glucose. Glucose is a form of sugar in the blood - it is the principal source of fuel for our bodies.

When our food is digested, the glucose makes its way into our bloodstream. Our cells use the glucose for energy and growth. However, glucose cannot enter our cells without insulin being present - insulin makes it possible for our cells to take in the glucose.

Insulin is a hormone that is produced by the pancreas. After eating, the pancreas automatically releases an adequate quantity of insulin to move the glucose present in our blood into the cells, as soon as glucose enters the cells blood-glucose levels drop.

A person with diabetes has a condition in which the quantity of glucose in the blood is too elevated (hyperglycemia). This is because the body either does not produce enough insulin, produces no insulin, or has cells that do not respond properly to the insulin the pancreas produces. This results in too much glucose building up in the blood. This excess blood glucose eventually passes out of the body in urine. So, even though the blood has plenty of glucose, the cells are not getting it for their essential energy and growth requirements.

Doctors can determine whether a patient has a normal metabolism, prediabetes or diabetes in one of three different ways - there are three possible tests:

Diabetes comes from Greek, and it means a "siphon". Aretus the Cappadocian, a Greek physician during the second century A.D., named the condition diabainein. He described patients who were passing too much water (polyuria) - like a siphon. The word became "diabetes" from the English adoption of the Medieval Latin diabetes.

In 1675, Thomas Willis added mellitus to the term, although it is commonly referred to simply as diabetes. Mel in Latin means "honey"; the urine and blood of people with diabetes has excess glucose, and glucose is sweet like honey. Diabetes mellitus could literally mean "siphoning off sweet water".

In ancient China people observed that ants would be attracted to some people's urine, because it was sweet. The term "Sweet Urine Disease" was coined.

All types of diabetes are treatable. Diabetes type 1 lasts a lifetime, there is no known cure. Type 2 usually lasts a lifetime, however, some people have managed to get rid of their symptoms without medication, through a combination of exercise, diet and body weight control.

Researchers from the Mayo Clinic Arizona in Scottsdale showed that gastric bypass surgery can reverse type 2 diabetes in a high proportion of patients. They added that within three to five years the disease recurs in approximately 21% of them. Yessica Ramos, MD., said "The recurrence rate was mainly influenced by a longstanding history of Type 2 diabetes before the surgery. This suggests that early surgical intervention in the obese, diabetic population will improve the durability of remission of Type 2 diabetes." (Link to article)

Patients with type 1 are treated with regular insulin injections, as well as a special diet and exercise.

Patients with Type 2 diabetes are usually treated with tablets, exercise and a special diet, but sometimes insulin injections are also required.

If diabetes is not adequately controlled the patient has a significantly higher risk of developing complications.

Below is a list of possible complications that can be caused by badly controlled diabetes:

Written by Markus MacGill. Last updated: 5 January 2016.

Disclaimer: This informational section on Medical News Today is regularly reviewed and updated, and provided for general information purposes only. The materials contained within this guide do not constitute medical or pharmaceutical advice, which should be sought from qualified medical and pharmaceutical advisers.

Please note that although you may feel free to cite and quote this article, it may not be re-produced in full without the permission of Medical News Today. For further details, please view our full terms of use

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Precision Medicine – Food and Drug Administration

August 4th, 2016 9:40 am

FDA's Role in the Precision Medicine Initiative

Most medical treatments are designed for the "average patient" as "one-size-fits-all-approach," that is successful for some patients but not for others. Precision medicine, sometimes known as "personalized medicine" is an innovative approach to disease prevention and treatment that takes into account differences in peoples genes, environments and lifestyles.

Advances in precision medicine have already led to powerful new discoveries and several new FDA-approved treatments that are tailored to specific characteristics of individuals, such as a persons genetic makeup, or the genetic profile of an individuals tumor. Patients with a variety of cancers routinely undergo molecular testing as part of patient care, enabling physicians to select treatments that improve chances of survival and reduce exposure to adverse effects.

To advance these developments, President Obamas Precision Medicine Initiative seeks to identify genetically-based drivers ofdisease in order to develop new, more effective treatments. FDAs role is to ensure the accuracy of genetic tests, many of which are derived from next generation sequencing, a rapid and fairly inexpensive technology that collects data on a persons entire genome.Researchers are combing through segments of this data to look for genetic variants, potentially meaningful differences that might eventually result in a treatment.

However, the vast amount of information generated through next generation sequencing (NGS) poses novel regulatory issues for FDA.Recognizing these challenges, FDA is at work on a workable regulatory platform that will encourage innovation while ensuring accuracy. To get there, weve been issuing discussion papers, holding workshops and collaborating with our stakeholders.

In addition, FDA has created precisionFDA, a community research and development portal that allows for testing, piloting, and validating existing and new bioinformatics approaches to NGS processing.

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Ophthalmology & Visual Sciences: University of Maryland …

August 4th, 2016 9:40 am

The University of Maryland School of Medicine established the first department for diseases of the eye in the United States in 1873. Since then, the Department of Ophthalmology and Visual Scienceshas played an integral part in the school's curriculum. This dedication to better sight for all has led to many research and surgical innovations, including the creation of the modern-day ophthalmoscope and the first surgery to correct strabismus.

It was a professor at the school, George Frick, who wrote "A Treatise on Diseases of the Eye" in 1824. The first book on ophthalmology by an American author, it immediately became the "bible" for those teaching in the field. Today's faculty continue to maintain high profiles as experts in the visual sciences, as evidenced by their continuous funding in this extremely competitive specialty.

Faculty from the Department of Ophthalmology and Visual Sciences are involved in the education of students from their very first year of med school through residencies, fellowships and beyond. This instruction is primarily hands-on, giving student early exposure in dealing with the patient population.

As we strive to improve the services we provide to the community, we continue to place a special emphasis on communication with our patients, our colleagues and the citizens of Maryland. Please contact us with your questions regarding the latest treatments for ophthalmic disease or for information about our research endeavors, open faculty positions or training opportunities.

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integrative medicine – The Skeptic’s Dictionary – Skepdic.com

August 4th, 2016 9:40 am

Experts in the psychology of human error have long been aware that even highly trained experts are easily misled when they rely on personal experience and informal decision rules to infer the causes of complex events. --Barry Beyerstein

According to [Andrew] Weil, many of his basic insights about the causes of disease and the nature of healing come from what he calls "stoned thinking," that is, thoughts experienced while under the influence of psychedelic agents or during other states of "altered consciousness" induced by trances, ritual magic, hypnosis, meditation, and the like. --Arnold S. Relman, M.D.

They have so many healers there [Nevada City/Grass Valley] it makes you sick. -- U. Utah Phillips

If you mix cow pie with apple pie, it does not make the cow pie taste better; it makes the apple pie worse. --Mark Crislip

Integrative medicine is a synonym for "alternative" medicine that, at its worst, integrates sense with nonsense. At its best, integrative medicine supports both consensus treatments of science-based medicine and treatments that the science, while promising perhaps, does not justify. It mixes the scientific with the metaphysical ("spirit-mind-body connection" is a favorite expression) and the scientifically untested, discredited, or questionable. Defenders of integrative medicine have an exceptionally high opinion of things "natural" and "organic."

The expression is a marketing term popularized by Andrew Weil, M.D. Integrative medicine is not a medical "specialty," nor is it special or superior to plain old science-based medicine. As David Gorski, M.D., says, "integrative medicine" is a brand, not a specialty.note Weil's branding and marketing strategy has paid off. The University of Arizona has given him his own Institute of Integrative Medicine to direct.

Weil graduated from Harvard Medical School but did not complete a residency nor, as far as I can ascertain, ever take the medical boards in any state.

After a one-year internship at Mount Zion Hospital in San Francisco in 1968-69, he began what was supposed to have been a two-year tour of duty at the National Institute of Mental Health. He resigned after a year. He says it was because of official opposition to his work with marijuana. He then left the world of allopathic medicine entirely, to go off to an Indian reservation in South Dakota to study with a Sioux medicine man and learn about herbal medicine and ritual healing. "On the reservation," he says, "I participated in sweat lodge ceremonies, grew a beard, and `dropped out.'" At home afterward, "I started to practice yoga, experiment with vegetarianism, and learn to meditate." (Relman 1998)

Apparently, he continued his herbal research during an extensive stay in South America.

After medical school, he decided, he would forgo the young doctor's traditional apprenticeship as a hospital intern and resident and instead devote his time to traveling through the forests and villages of South America, studying not the great engine of Western medicine but the gentle power of the curative herb. Weil spent more than three years in the field in Peru, Ecuador, Colombia and elsewhere, and when he returned to the U.S. in the mid-1970s, he decided that he would make his living teaching, writing and otherwise spreading the alternative-medicine word. (Kluger 1997)

Today, Weil mixes scientific medicine with Ayurvedic and other forms of quackery and calls this practice "integrative medicine." One of his main tenets is: "It is better to use natural, inexpensive, low-tech and less invasive interventions whenever possible." However, there is no scientific evidence for the claim that natural interventions are always superior to artificial ones. Millions of people use herbs and natural products for a variety of conditions, such as calcium, echinacea, ginseng, ginkgo biloba, glucosamine, saw palmetto, shark cartilage, and St. John's wort. All of these, when tested scientifically, have failed to support the traditional wisdom regarding their healing powers. Pharmaceuticals and other treatments are much superior to most herbal remedies. If a plant has been shown to be effective as a healing agent, the active ingredient has been extracted and tested scientifically and is part of scientific medicine. Otherwise, any beneficial effect following use of the herb or plant is probably best explained as due to the placebo effect, natural regression, the body's own natural healing processes, or to some other non-herbal factor.

Why so many peopleincluding many highly educated and medically trained peoplebelieve in the efficacy of quack remedies is a complex issue. As Barry Beyerstein has pointed out in his most thorough analysis of this phenomenon, there are a "number of social, psychological, and cognitive factors that can convince honest, intelligent, and well-educated people that scientifically-discredited [or untested] treatments have merit" (Beyerstein 1999). The typical believer in untested or discredited medical treatments accepts uncritically the apparently clear messages of personal experience that such treatments are effective. To the uncritical thinker, many worthless or harmful treatments seem to "work" (the pragmatic fallacy). Such people are either unaware of or intentionally ignore the many perceptual and cognitive biases that deceive us into thinking there are causal relationships between quack treatments and feeling better or recovering from some illness or disease. They uncritically place "more faith in personal experience and intuition than on controlled, statistical studies" (Beyerstein 1999).

Furthermore, the mass media is rarely critical of "alternative" healing and often presents non-scientific medicine in a very positive light. And critics of complementary and alternative medicine (CAM) are often stereotyped as lackeys for the AMA or the pharmaceutical firms. For example, when a recent double-blind study of 225 men with enlarged prostates [benign prostate hyperplasia or BPH] found no statistically significant difference between those who took saw palmetto and those who took a placebo twice a day for one year, a user of saw palmetto wrote a letter to the editor of the Sacramento Bee in which he claimed that the study was

an attempt by the pharmaceutical industry to promote manufactured drugs that help the prostrate.

I have had a long experience using saw palmetto in various formulations. It works and it has prevented me from having surgery in my 50s. I am now in my mid-60s. I was desperate at the time. Saw palmetto is a blessing.

The Bee should investigate how the pharmaceutical industry manipulates public thought and perception. It's a much more interesting concept. (Letters to the editor, Sacramento Bee, Feb. 25, 2006).

Rather than accept the results of a scientific study, the letter writerlike many purveyors and proponents of quack treatmentstrusts his interpretation of his personal experience, even though it is contradicted by a double-blind scientific experiment.* He also brings up a common claim among believers in quack remedies: the pharmaceutical industry has rigged the game so they can sell more drugs. The letter writer believes that the pharmaceutical industry has somehow manipulated the seven scientists who did this study, as well as the New England Journal of Medicine, which published their research.

The letter writer is probably not the least bit interested in the fact that the National Institutes of Health, which spends millions of dollars each year trying to validate quack treatments, has funded a major new study of saw palmetto and another commonly-used herbal treatment for BPH.* The new study will involve several hundred patients at 11 centers nationwide. Such information is probably of no interest to this letter writer, since he already knows that "saw palmetto is a blessing." Of course, if the results of the new study support the claim that saw palmetto is an effective treatment for BPH, he may view the study with a more positive eye, as it will confirm his bias. In any case, the fact that someone has not had prostate problems since he started taking some herb is not very strong evidence that the herb has had anything to do with it. His prostate problemswhatever they may have beenmay have subsided had he done nothing. It is possible that he stopped drinking caffeinated beverages at the same time he started taking the herb and that the entire positive effect he feels is due to not ingesting caffeine. Perhaps he began ejaculating several times a week after his problem emerged.* A scientific study can control for various factors that might be causing an outcome and isolate the most likely significant factor. Intuition is unable to do this.

Many believers in integrative medicine are led to their uncritical evaluation of personal experience because of their deep commitment to metaphysical notions such as subtle energy or spiritual forces. They do not accept that the biological world is governed by mechanistic processes determined by laws of nature. Scientific or evidence-based medicine is rooted in a set of beliefs about reality that seem to contradict their beliefs in non-physical entities and forces that are at the core of their perception of reality. They don't necessarily reject science altogether, but they are as likely to put their faith in prayer, intuition, meditation, or visions induced by drugs, as they are in randomized, double-blind, controlled studies.

Scientific medicine is not infallible, of course. And we should not draw strong conclusions from a single study. That goes for both skeptics and believers. The results of a scientific study should usually be taken to hold tentatively, until significant replication or other strong supportive evidence leads to a consensus. Even then, the door should never be closed to further investigation, should new data arise that warrants it. The tendency of most of us, however, is to be uncritical and accepting of a study if it seems to support our beliefs. A skeptic might hail the Bent et al. study that found no significant benefit of saw palmetto, while a believer might reject the study because of a perceived fault. One need not speculate about drug company conspiracies to find a reason to reject a scientific study. No study is perfect. It is not difficult to find fault with nearly every scientific study ever done: the study did not go on long enough, the dosage was too small or too large or was given too frequently or not frequently enough, the placebo wasn't masked well enough, the sample was too small, the randomization process wasn't perfect, and so on.

Furthermore, each human being is a unique and extremely complex biological organism. The same chemicals may affect different people in significantly different ways. They may even affect the same person differently at different times. It is not uncommon for a well-designed double-blind study to contradict earlier studies (as was the case with the Bent et al. study). It should not be a shock to anyone if the next saw palmetto study finds that it significantly improves BPH, but if it does that should not be the end of such studies. Eventually, a consensus should be reached about the effectiveness of this smelly herb to heal the prostate. But even when that consensus is reached, there will still be a few contrarians who will continue to prescribe and sell saw palmetto to patients concerned about prostate problems. Some of these will base their contrary belief on their intuitions but others will say that further studies need to be done because, after all, there have been some studies that have indicated it is effective and there are still many men who swear by it. It is always possible that the next study will prove beyond a reasonable doubt that it is effective. And if it doesn't? Well, there is always the next study and the one after that.

Randomized double-blind studies are not perfect, but they are much more reliable than anecdotes and personal experience because they allow us the opportunity to control our observations in such a way as to minimize the effect of the many perceptual and cognitive biases that affect us all and are great sources of error. We are prone to wishful thinking, "a willingness to endorse comforting beliefs and to accept, uncritically, information that reinforces our core attitudes and self-esteem" (Beyerstein 1999). We often see patterns that aren't really there and find significance in coincidental occurrences.

The pioneers of the scientific revolution were aware of the large potential for error when informal reasoning joins forces with our penchant for jumping to congenial conclusions. By systematizing observations, studying large groups rather than a few isolated individuals, instituting control groups, and trying to eliminate confounding variables, these innovative thinkers hoped to reduce the impact of the frailties of reasoning that lead to false beliefs about how the world works. None of these safeguards exists when we base our decisions merely on a few satisfied customers personal anecdotesunfortunately, these stories are the alternative practitioners stock in trade. Psychologists interested in judgmental biases have repeatedly demonstrated that human inference is especially vulnerable in complex situations, such as that of evaluating therapeutic outcomes, which contain a mix of interacting variables and a number of strong social pressures. Add a pecuniary interest in a particular outcome, and the scope for self-delusion is immense. (Beyerstein 1999).

The appeal of Weil's integrative medicine is that he mixes sound scientific knowledge and advice with illogical hearsay. For example, on his Men's Health Internet page, he provides scientific information regarding men with prostate problems. He offers common sense advice such as don't ingest caffeine and alcohol if you are having trouble with frequent urination, since these substances will increase the need to urinate. But he also advises men to eat more soy because: "Asian men have a lower risk of BPH and some researchers believe it is related to their intake of soy foods." As Sally Fallon and Mary G. Enig note, however: "the same logic requires us to blame high rates of cancers of the esophagus, stomach, thyroid, pancreas and liver in Asian countries on consumption of soy" (Soy Alert! 2001). Weil also states that saw palmetto "may help" BPH because: "There is clinical evidence that saw palmetto can help shrink the size of the prostate, and it may help promote healthy prostate function." Now we know there is clinical evidence that saw palmetto doesn't help shrink the size of the prostrate.

On the positive side, Weil notifies the reader: "You should inform your health care practitioner you are using this product." Your physician needs to know what supplements you are taking because what he or she prescribes to you may interact adversely with the herbs you are taking.

For those who want to study alternatives to scientific medicine, the University of Arizona seems like the hot spot. It not only supports the work of Gary Schwartz and the Center for Frontier Medicine in Biofield Science, Andrew Weil heads its integrative medicine program. Why would a major university risk its reputation by supporting such programs? Because these programs are very popular with the masses, the media, many medical schools and physicians, and politicians. Furthermore, there is significant grant money available to such programs through agencies like the NIH and the university gets a significant cut of whatever money the grantees take in. Someday we may look back at this period in our history and see the "alternative" science movement as a well-engineered social movement that created a very popular mass delusion on par with the tulip mania of 17th century Holland.

__________

Note: Although "integrative medicine is not recognized as a speciality by the American Board of Medical Specialities. The ABMS is, as one disgruntled practitioner of integrative medicine put it, "a guild." Membership requires approval by every subspecialty member and there are more than 100 subspecialties. Integrative medicine isn't one of them. Other certifiying boards are more like clubs. You meet some minimum requirement and you pays your dues and you're in. Weil has cleverly formed his own American Board of Integrative Medicine, which has been accepted as a member of the American Board of Physician Specialties (ABPS). The ABPS is more like a club than a guild. Physicians certified by ABPS and licensed by theMedical Board of Californiaare prohibited from using the term "board certified" unless they are also certified by theAmerican Board of Medical Specialties.* From 2000 until 2014, the American Board of Integrative and Holistic Medicine provided the only board certification exam in integrative medicine. As of May 2014, the American Board of Integrative Medicine will replace the ABIHM for board certification in integrative medicine. So, Weil will be soon able to create board certified practitioners of integrative medicine, but they will not be allowed call themselves "board certified" in California. I don't know about other states.

See also alternative medicine, complementary medicine, energy, frontier medicine, hidden persuaders, integrative oncology, holistic medicine, NCCAM, and supplements.

* Ray Hyman provides an example of a chiropractor who agreed to a double-blind controlled test of applied kinesiology (AK). After AK had failed the test, the chiropractor said: "You see, that is why we never do double-blind testing anymore. It never works!"

further listening

further reading

I have written several articles and short pieces about alternative-health related topics. The following is a list of those I think are most relevant to the article above.

Evaluating Personal Experience

Energy Healing: Looking in All the Wrong Places

Evaluating Acupuncture Studies: Laughable vs. Dangerous Delusions

The trouble with acupuncture, homeopathy, etc.

Sticking Needles into Acupuncture Studies

How safe are alternative therapies?

Oprah and Oz spreading superstition at the speed of night

Ancient Wisdom

Prescribing Placebos

Mesmerized by hypnotherapy

Statistics and Medical Studies

Review of R. Barker Bausell's Snake Oil Science: The Truth about Complementary and Alternative Medicine

Bunk 7 - Needles and Nerves

Acupuncture shown NOT to ease back and neck pain after surgery

cosmetic acupuncture

books and articles

Barrett, Stephen and William T. Jarvis. eds. The Health Robbers: A Close Look at Quackery in America, (Amherst, N.Y.: Prometheus Books, 1993).

Bausell, R. Barker. (2007). Snake Oil Science: The Truth about Complementary and Alternative Medicine. Oxford University Press.

Gardner, Martin. Fads and Fallacies in the Name of Science (New York: Dover Publications, Inc., 1957), ch. 16.

Hall, Harriet. (2006). "Andrew Weil: Harvard Hatched a Gullible Guru." Skeptical Inquirer. Volume 30, No. 1. This is a review of Weil's Natural Health, Natural Medicine.

Mackay, Charles. Extraordinary Popular Delusions & the Madness of Crowds (Crown Publishing, 1995).

Park, Robert L. Voodoo Science: The Road from Foolishness to Fraud (Oxford U. Press, 2000).

Randi, James. The Faith Healers (Amherst, N.Y.: Prometheus Books, 1989).

Raso, Jack. "Alternative" Healthcare: A Comprehensive Guide (Amherst, NY: Prometheus Books, 1994).

Raso, Jack. "Mystical Medical Alternativism," Skeptical Inquirer, Sept/Oct 1995.

Sampson, Wallace and Lewis Vaughn, editors. Science Meets Alternative Medicine: What the Evidence Says About Unconventional Treatments (Prometheus Books, 2000).

Shapiro, Rose. 2008. Suckers: How Alternative Medicine Makes Fools of Us All. Random House.

Singh, Simon and Edzard Ernst. 2008. Trick or Treatment: The Undeniable Facts about Alternative Medicine. W. W. Norton.

Stenger, Victor J. "Quantum Quackery," Skeptical Inquirer. January/February 1997.

news

The believers: Alternative therapies are increasingly mainstream. That means headaches for scientistsand no cure in sight "The $1.5 billion that taxpayers have devoted to NCCAM has brought meagre returns....In a paper in the New England Journal of Medicine last July [Ted Kaptchuk] described an experiment with asthma inhalers. The real ones improved patients lung function by 20%, compared with 7% for the alternatives: a dummy inhaler or acupuncture. But patients judged the effectiveness of the three therapies to be about the same." Not accounting for the difference in real vs. perceived benefits of treatment may explain why placebo medicine hasn't gone extinct.

Why Medical Schools Should Not Teach Integrative Medicine "Pseudoscience is insinuating itself into our medical schools across the nation, going by the name Integrative Medicine. Integrative medicine is just the latest buzzword for a collection of superstitions, myths, and pseudoscience that has gone by various names over the years. First it was Holistic medicine, and once that fell out of favor, it became Alternative medicine, followed soon after by Complementary and Alternative medicine (CAM), and lately Integrative medicine. These names cant disguise the fact that many of the practices lumped together are bad medicine. What disturbs me particularly, as a professor, is that CAM is moving into the medical curriculum at respectable medical schools, including the University of Maryland."

UCSF Osher Center for Integrative Medicine Celebrates New Building The $37 million project was made possible through gifts from Bernard and Barbro Osher.... Our hope, noted the Oshers, is that the activities undertaken in this structure, enhanced by the Takahashi meditation garden, will promote good health and wellness, respect for the healing traditions of many cultures and individual progress toward more balanced and meaningful lives.

"The new Osher building underscores UCSFs commitment to increasing access to integrative medicine and making it a larger part of the treatment relationship between medical caregivers and patients."

And that's a good thing? Orac doesn't think so.

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Integrative medicine and the point of credulity by John C McLachlan

In the spirit of Alan Sokal, McLachlan, a professor of medical education, responded to a mass circulated email invitation to submit a paper to something called The Jerusalem Conference on Integrative Medicine. Dr. McLachlan received the following response from the conference organizers:

We are happy to inform you that the Scientific Committee has reached its (sic) decision and that your paper has been accepted and you will be able to present your lecture. The time frame will be 15-20 minutes. Considering the tight schedule, I will appreciate if youll confirm your participation in the convention.

What was his proposal? It was a joke and should have been recognized as a joke by serious medical people. McLachlan's concern that "integrative medicine" is being used to smuggle alternative practices into rational medicine by way of lowered standards of critical thinking seems to have been justified. Here's his proposal:

...I have discovered a new version of reflexology, which identifies a homunculus represented in the human body, over the area of the buttocks. The homunculus is inverted, such that the head is represented in the inferior position, the left buttock corresponds to the right hand side of the body, and the lateral aspect is represented medially. As with reflexology, the map responds to needling, as in acupuncture, and to gentle suction, such as cupping. In my studies, responses are stronger and of more therapeutic value than those of auricular or conventional reflexology. In some cases, the map can be used for diagnostic purposes.

The Academic Woo Aggregator (a list of all the academic medical centers with woo programs)- Orac

A new use for magic mushrooms

Social and judgmental biases that make inert treatments seem to work by Barry L. Beyerstein (1999)

The Belief Engine by Jim Alcock (1995)

A Trip to Stonesville: Some Notes on Andrew Weil by Arnold S. Relman, M.D. (1998)

Why the National Center for Complementary and Alternative Medicine (NCCAM) Should Be Defunded by Wallace I. Sampson, M.D.

Mr. Natural by Jeffrey Kluger Time Magazine May 12, 1997

QuackWatch with Dr. Stephen Barrett

Fraud & Quackery: Internet Resources: Alternative Medicine

Alternatives to Medicine Topical Index Skeptic's Dictionary

The Museum of Quackery

The Medical Messiahs: A Social History of Health Quackery in Twentieth-Century America Chapter 18: Anti-Quackery, Inc. James Harvey Young, PhD

blogs

new Old wine in a new skin: The Society for Integrative Oncology promotes integrating pseudoscience into oncology by Orac "Any medical society that allows naturopaths to be members and touts integrating their expertise into medicine has automatically lost any claim to scientific legitimacy, given that naturopathy consists of a veritable cornucopia ofpretty much every quackery known to humankind, including homeopathy (which isrequired study for naturopathy students and the knowledge of which is tested in the NPLEX, the naturopathic certification examination)....Proponents of integrative oncology are no doubt well-meaning practitioners who think theyre doing good. They even go out of their way to condemn quackery, as though to demonstrate that what they embrace is not quackery. However, as they try to distance themselves from obvious cancer quackery, as Barrie Cassileth, who heads up the integrative medicine service at Memorial Sloan-Kettering Cancer Center,did not too long ago, they seem oblivious to the fact that much of what they accept as potentially part of integrative oncology, such as traditional Chinese medicine, acupuncture, reiki, naturopathy, and the like, is based on the very same pseudoscience and magical thinking that the quackery they condemn."

See also: Integrative oncology: Trojan horse, quackademic medicine, or both? by David Gorski, M.D. "Cancer patients, as I say frequently, are among the most vulnerable of patients. Many of them are facing a very unpleasant death without treatment; seeing that they receive the most effective medicines and treatments we have, free of quackery, is a moral imperative, and I fear that we will soon be failing our patients. We now even have aSociety of Integrative Oncologypromoting the integration of pseudoscience into oncology." Also by Dr. Gorski: Integrative oncology: The Trojan horse that is quackademic medicine infiltrates ASCO.

Even my alma mater, UCSD, has jumped on this bandwagon. San Diego has its own Center for Integrative Medicine. A 2013 symposium list of topics indicates what they are up to: "Topics include: optimal nutrition, physical activity, massage, manual therapies, acupuncture, herbs, biofeedback, meditation, guided imagery, integrative psychiatry, biofield therapies, expressive arts, yoga, and tai chi." Yes, a true mixture of apple pie and cow pie.[/new]

Integrative Medicine Invades the U.S. Military: Part One by Jann Bellamy, July 25, 2013 "If integrative medical practitioners and their proponents were simply directing their time, energy and resources toward facilitating a better model for delivering health care I suppose no one would have any problem. But they arent. They are claiming rights to an entirely new specialty in medicine. Proponents do this by advancing two dubious arguments. First, integrative medicine alone can deliver on this whole person model of care. Second, inclusion of alternative medicine is essential to good patient care."

Integrative Medicine: Patient-Centered Care is the new Medical Paternalism by Kimball Atwood "...the two most consistent IM pitches in recent yearsseen repeatedly in statements found in links from this postare that IM is 'preventive medicine' and that it involves 'patient-centered care.' I demolished the 'preventive' claim a couple of years ago, as did Drs. Lipson, Gorski, and probably others. Today Ill explain why the 'patient-centered care' claim is worse than fatuous."

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Center for Integrative Medicine – facebook.com

August 4th, 2016 9:40 am

Tai Chi Recharge class with Tim Russell Tuesday, September 2 through November 4 5:30 p.m. to 6:30 p.m. Montgomery Room of the Center on Main $10 per class when purchasing a package

By now, most Westerners are familiar with the many benefits attributed to the practice of Tai Chi (also spelled Tai Ji) like stress reduction, improved balance, and increased bone density. This class is designed to provide the Tai Chi benefits simply, without having to learn a formal form. It will be a low impact workout that gradually builds flexibility, strength and endurance. Beginners can join at any time and veterans can complement their current studies with an extra group practice focusing on drills, repetition and relaxation. This is a great fitness opportunity in a great space at a convenient time.

About the instructor: Tim Russell is a manual therapist specializing in soft tissue therapy who has been practicing Tai Chi for over twenty years. He has studied with four main teachers during that time, mainly focusing on the Yang and Chen style family forms.

Space is limited to 12 people so early registration is recommended. Call or come by Center Medspa 643-1980 For more information call Tim Russell at 643-1965

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Integrative Medicine | Department of Medicine

August 4th, 2016 9:40 am

Leading the transformation of health care by creating, educating, and actively supporting a community that embodies the philosophy and practice of healing-oriented medicine, addressing mind, body and spirit.

Dr. Andrew Weil, Director of the Center for Integrative Medicine presents to a group outside the Center.

The Arizona Center for Integrative Medicine was founded in 1994 at the University of Arizona by Dr. Andrew Weil. Since then, the Center has grown from a visionary concept to the recognized world leader in Integrative Medical education. The first Residential Fellowship class began their studies in 1997, with four fellows. Today, our Fellowship has grown to accommodate 120 fellows per year.

We built the Center on the premise that the best way to change a field is to educate the most gifted professionals and place them in settings where they can, in turn, teach others. Our approach has clearly made an impact on the field of integrative medicine, and more importantly, on medicine as a whole. In addition to educational leadership, we are committed to providing the finest clinical care in integrative medicine and engaging in cutting edge research.

The Center defines integrative medicine as healing-oriented medicine that takesaccount of the whole person (mind, body, and spirit), including all aspects of lifestyle.It emphasizes the therapeutic relationship between practitioner and patient and makes use of all appropriate therapies, both conventional and alternative.

The Arizona Center for Integrative Medicine is committed to developing and delivering world-class continuing education in IM for students, professionals and public. Our programs include:

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UC Davis Integrative Medicine – Official Blog

August 4th, 2016 9:40 am

Welcome to UC Davis Integrative Medicine. Our blog is jam-packed with information on everything from nutrition and plant-based diets to exercise and stress management so that you can live a healthier, happierlife

By Rosane Oliveira on March 31, 2016March 31, 2016

Its been quite a celebration around here lately with UCDIMs 5-year anniversary.

Ive spent a lot of time thinking about the past, reflecting on how far we have come.

So before we embark on the future and our next five years, (more)

By Rosane Oliveira on March 29, 2016March 31, 2016

We are here at the fourth and final installment of the One Health Series.

From describing the One Health movement to discussing why what we eat really mattersto talking about cows, I would now love to complete our series by telling you a story. (more)

By Rosane Oliveira on March 27, 2016March 28, 2016

The journey of a thousand milesstarts with a single step. ~ Lao Tzu

It all started exactly 5 years ago.

That was when we took the first step of our journey here (more)

By Rosane Oliveira on March 20, 2016March 17, 2016

H20.

More commonly known as water. (more)

By Rosane Oliveira on March 15, 2016March 25, 2016

For our third installment in this months One Health series, we are going to broach the subject of how humans (as omnivores) differ from other animals on this planet who are true herbivores. I feel it is very important to set the record straight on this topic. (more)

By Rosane Oliveira on March 13, 2016March 14, 2016

My new motto is 3.14159265358.

Let me explain.

That number is the number Pi. (more)

By Rosane Oliveira on March 10, 2016March 9, 2016

The doctor of the future will give no medicine, but will interest his patient in the care of the human frame, in diet and in the cause and prevention of disease. ~Thomas A. Edison

The One Health initiative is a global conversation tackling (more)

By Rosane Oliveira on March 6, 2016March 5, 2016

Were not going to lie sticking to a plant-based diet can be tough at the beginning.

Between coming up with creative recipes and simply knowing whats healthful and whats not, it can be a challenge. (more)

By Rosane Oliveira on March 1, 2016March 2, 2016

Between animal and human medicine there are no dividing linesnor should there be. The object is different but the experience obtained constitutes the basis of all medicine.~ Rudolf Virchow, MD

The world is getting smaller. (more)

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Elsevier Current Opinion – Current Opinion in Biotechnology

August 4th, 2016 9:40 am

IMPACT FACTOR: 7.117 5-Year Impact Factor: 7.983 Issues per year: 6 issues Editorial Board

The Current Opinion journals were developed out of the recognition that it is increasingly difficult for specialists to keep up to date with the expanding volume of information published in their subject. In Current Opinion in Biotechnology, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in biotechnology in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.

Division of the subject into sections The subject of biotechnology is divided into themed sections, each of which is reviewed once a year. The amount of space devoted to each section is related to its importance.

Analytical biotechnology Plant biotechnology Food biotechnology Energy biotechnology Environmental biotechnology Systems biology Nanobiotechnology Tissue, cell and pathway engineering Chemical biotechnology Pharmaceutical biotechnology

Selection of topics to be reviewed Section Editors, who are major authorities in the field, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasised. Section Editors commission reviews from authorities on each topic that they have selected.

Reviews Authors write short review articles in which they present recent developments in their subject, emphasising the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.

Editorial Overview Section Editors write a short overview at the beginning of the section to introduce the reviews and to draw the reader's attention to any particularly interesting developments. This successful format has made Current Opinion in Biotechnology one of the most highly regarded and highly cited review journals in the field (Impact factor = 8.035).

Ethics in Publishing: General Statement

The Editor(s) and Publisher of this Journal believe that there are fundamental principles underlying scholarly or professional publishing. While this may not amount to a formal 'code of conduct', these fundamental principles with respect to the authors' paper are that the paper should: i) be the authors' own original work, which has not been previously published elsewhere, ii) reflect the authors' own research and analysis and do so in a truthful and complete manner, iii) properly credit the meaningful contributions of co-authors and co-researchers, iv) not be submitted to more than one journal for consideration, and v) be appropriately placed in the context of prior and existing research. Of equal importance are ethical guidelines dealing with research methods and research funding, including issues dealing with informed consent, research subject privacy rights, conflicts of interest, and sources of funding. While it may not be possible to draft a 'code' that applies adequately to all instances and circumstances, we believe it useful to outline our expectations of authors and procedures that the Journal will employ in the event of questions concerning author conduct. With respect to conflicts of interest, the Publisher now requires authors to declare any conflicts of interest that relate to papers accepted for publication in this Journal. A conflict of interest may exist when an author or the author's institution has a financial or other relationship with other people or organizations that may inappropriately influence the author's work. A conflict can be actual or potential and full disclosure to the Journal is the safest course. All submissions to the Journal must include disclosure of all relationships that could be viewed as presenting a potential conflict of interest. The Journal may use such information as a basis for editorial decisions and may publish such disclosures if they are believed to be important to readers in judging the manuscript. A decision may be made by the Journal not to publish on the basis of the declared conflict.

For more information, please refer to: http://www.elsevier.com/wps/find/authorshome.authors/conflictsofinterest

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History of genetic engineering – Wikipedia, the free …

August 4th, 2016 9:40 am

Genetic modification caused by human activity has been occurring since around 12,000 BC, when humans first began to domesticate organisms. Genetic engineering as the direct transfer of DNA from one organism to another was first accomplished by Herbert Boyer and Stanley Cohen in 1973. The first genetically modified animal was a mouse created in 1973 by Rudolf Jaenisch. In 1983 an antibiotic resistant gene was inserted into tobacco, leading to the first genetically engineered plant. Advances followed that allowed scientists to manipulate and add genes to a variety of different organism and induce a range of different effects.

In 1976 the technology was commercialised, with the advent of genetically modified bacteria that produced somatostatin, followed by insulin in 1978. Plants were first commercialised with virus resistant tobacco released in China in 1992. The first genetically modified food was the Flavr Savr tomato marketed in 1994. By 2010, 29 countries had planted commercialized biotech crops. In 2000 a paper published in Science introduced golden rice, the first food developed with increased nutrient value.

Genetic engineering is the direct manipulation of an organism's genome using certain biotechnology techniques that have only existed since the 1970s.[2] Human directed genetic manipulation was occurring much earlier, beginning with the domestication of plants and animals through artificial selection. The dog is believed to be the first animal domesticated, possibly arising from a common ancestor of the grey wolf,[1] with archeologically evidence dating to about 12,000 BC.[3] Other carnivores domesticated in prehistoric times include the cat, which cohabited with human 9 500 years ago.[4] Archeologically evidence suggests sheep, cattle, pigs and goats were domesticated between 9 000 BC and 8 000 BC in the Fertile Crescent.[5]

The first evidence of plant domestication comes from emmer and einkorn wheat found in pre-Pottery Neolithic A villages in Southwest Asia dated about 10,500 to 10,100 BC. The Fertile Crescent of Western Asia, Egypt, and India were sites of the earliest planned sowing and harvesting of plants that had previously been gathered in the wild. Independent development of agriculture occurred in northern and southern China, Africa's Sahel, New Guinea and several regions of the Americas.[7] The eight Neolithic founder crops (emmer wheat, einkorn wheat, barley, peas, lentils, bitter vetch, chick peas and flax) had all appeared by about 7000 BC.[8]Horticulture first appears in the Levant during the Chalcolithic period about 6 800 to 6,300 BC. Due to the soft tissues, archeological evidence for early vegetables is scarce. The earliest vegetable remains have been found in Egyptian caves that date back to the 2nd millennium BC.

Selective breeding of domesticated plants was once the main way early farmers shaped organisms to suit their needs. Charles Darwin described three types of selection: methodical selection, wherein humans deliberately select for particular characteristics; unconscious selection, wherein a characteristic is selected simply because it is desirable; and natural selection, wherein a trait that helps an organism survive better is passed on.[11]:25 Early breeding relied on unconscious and natural selection. The introduction of methodical selection is unknown.[11]:25 Common characteristics that were bred into domesticated plants include grains that did not shatter to allow easier harvesting, uniform ripening, shorter lifespans that translate to faster growing, loss of toxic compounds, and productivity.[11]:2730 Some plants, like the Banana, were able to be propagated by vegetative cloning. Offspring often did not contain seeds, and therefore sterile. However, these offspring were usually juicier and larger. Propagation through cloning allows these mutant varieties to be cultivated despite their lack of seeds.[11]:31

Hybridization was another way that rapid changes in plant's makeup were introduced. It often increased vigor in plants, and combined desirable traits together. Hybridization most likely first occurred when humans first grew similar, yet slightly different plants in close proximity.[11]:32Triticum aestivum, wheat used in baking bread, is an allopolyploid. Its creation is the result of two separate hybridization events.[12]

X-rays were first used to deliberately mutate plants in 1927. Between 1927 and 2007, more than 2,540 genetically mutated plant varieties had been produced using x-rays.[13]

Various genetic discoveries have been essential in the development of genetic engineering. Genetic inheritance was first discovered by Gregor Mendel in 1865 following experiments crossing peas. Although largely ignored for 34 years he provided the first evidence of hereditary segregation and independent assortment.[14] In 1889 Hugo de Vries came up with the name "(pan)gene" after postulating that particles are responsible for inheritance of characteristics[15] and the term "genetics" was coined by William Bateson in 1905.[16] In 1928 Frederick Griffith proved the existence of a "transforming principle" involved in inheritance, which Avery, MacLeod and McCarty later (1944) identified as DNA. Edward Lawrie Tatum and George Wells Beadle developed the central dogma that genes code for proteins in 1941. The double helix structure of DNA was identified by James Watson and Francis Crick in 1953.

As well as discovering how DNA works, tools had to be developed that allowed it to be manipulated. In 1970 Hamilton Smiths lab discovered restriction enzymes that allowed DNA to be cut at specific places and separated out on an electrophoresis gel. This enabled scientists to isolate genes from an organism's genome.[17]DNA ligases, that join broken DNA together, had been discovered earlier in 1967[18] and by combining the two enzymes it was possible to "cut and paste" DNA sequences to create recombinant DNA. Plasmids, discovered in 1952,[19] became important tools for transferring information between cells and replicating DNA sequences. Frederick Sanger developed a method for sequencing DNA in 1977, greatly increasing the genetic information available to researchers. Polymerase chain reaction (PCR), developed by Kary Mullis in 1983, allowed small sections of DNA to be amplified and aided identification and isolation of genetic material.

As well as manipulating the DNA, techniques had to be developed for its insertion (known as transformation) into an organism's genome. Griffiths experiment had already shown that some bacteria had the ability to naturally uptake and express foreign DNA. Artificial competence was induced in Escherichia coli in 1970 when Morton Mandel and Akiko Higa showed that it could take up bacteriophage after treatment with calcium chloride solution (CaCl2).[20] Two years later, Stanley Cohen showed that CaCl2 treatment was also effective for uptake of plasmid DNA.[21] Transformation using electroporation was developed in the late 1980s, increasing the efficiency and bacterial range.[22] In 1907 a bacterium that caused plant tumors, Agrobacterium tumefaciens, was discovered and in the early 1970s the tumor inducing agent was found to be a DNA plasmid called the Ti plasmid.[23] By removing the genes in the plasmid that caused the tumor and adding in novel genes researchers were able to infect plants with A. tumefaciens and let the bacteria insert their chosen DNA into the genomes of the plants.[24]

In 1972 Paul Berg utilised restriction enzymes and DNA ligases to create the first recombinant DNA molecules. He combined DNA from the monkey virus SV40 with that of the lambda virus.[25]Herbert Boyer and Stanley N. Cohen took Berg's work a step further and introduced recombinant DNA into a bacterial cell. Cohen was researching plasmids, while Boyers work involved restriction enzymes. They recognised the complementary nature of their work and teamed up in 1972. Together they found a restriction enzyme that cut the pSC101 plasmid at a single point and were able to insert and ligate a gene that conferred resistance to the kanamycin antibiotic into the gap. Cohen had previously devised a method where bacteria could be induced to take up a plasmid and using this they were able to create a bacteria that survived in the presence of the kanamycin. This represented the first genetically modified organism. They repeated experiments showing that other genes could be expressed in bacteria, including one from the toad Xenopus laevis, the first cross kingdom transformation.[26][27][28]

In 1973 Rudolf Jaenisch created a transgenic mouse by introducing foreign DNA into its embryo, making it the worlds first transgenic animal.[29] Jaenisch was studying mammalian cells infected with simian virus 40 (SV40) when he happened to read a paper from Beatrice Mintz describing the generation of chimera mice. He took his SV40 samples to Mintz's lab and injected them into early mouse embryos expecting tumours to develop. The mice appeared normal, but after using radioactive probes he discovered that the virus had integrated itself into the mice genome.[30] However the mice did not pass the transgene to their offspring. In 1981 the laboratories of Frank Ruddle, Frank Constantini and Elizabeth Lacy injected purified DNA into a single-cell mouse embryo and showed transmission of the genetic material to subsequent generations.[31][32]

The first genetically engineered plant was tobacco, reported in 1983.[33] It was developed by Michael W. Bevan, Richard B. Flavell and Mary-Dell Chilton by creating a chimeric gene that joined an antibiotic resistant gene to the T1 plasmid from Agrobacterium. The tobacco was infected with Agrobacterium transformed with this plasmid resulting in the chimeric gene being inserted into the plant. Through tissue culture techniques a single tobacco cell was selected that contained the gene and a new plant grown from it.[34]

The development of genetic engineering technology led to concerns in the scientific community about potential risks. The development of a regulatory framework concerning genetic engineering began in 1975, at Asilomar, California. The Asilomar meeting recommended a set of guidelines regarding the cautious use of recombinant technology and any products resulting from that technology.[35] The Asilomar recommendations were voluntary, but in 1976 the US National Institute of Health (NIH) formed a recombinant DNA advisory committee.[36] This was followed by other regulatory offices (the United States Department of Agriculture (USDA), Environmental Protection Agency (EPA) and Food and Drug Administration (FDA)), effectively making all recombinant DNA research tightly regulated in the USA.[37]

In 1982 the Organization for Economic Co-operation and Development (OECD) released a report into the potential hazards of releasing genetically modified organisms into the environment as the first transgenic plants were being developed.[38] As the technology improved and genetically organisms moved from model organisms to potential commercial products the USA established a committee at the Office of Science and Technology (OSTP) to develop mechanisms to regulate the developing technology.[37] In 1986 the OSTP assigned regulatory approval of genetically modified plants in the US to the USDA, FDA and EPA.[39] In the late 1980s and early 1990s, guidance on assessing the safety of genetically engineered plants and food emerged from organizations including the FAO and WHO.[40][41][42][43]

The European Union first introduced laws requiring GMO's to be labelled in 1997.[44] In 2013 Connecticut became the first state to enacted a labeling law in the USA, although it would not take effect until other states followed suit.[45]

The ability to insert, alter or remove genes in model organisms allowed scientists to study the genetic elements of human diseases.[46]Genetically modified mice were created in 1984 that carried cloned oncogenes that predisposed them to developing cancer.[47] The technology has also been used to generate mice with genes knocked out. The first recorded knockout mouse was created by Mario R. Capecchi, Martin Evans and Oliver Smithies in 1989. In 1992 oncomice with tumor suppressor genes knocked out were generated.[47] Creating Knockout rats is much harder and only became possible in 2003.[48][49]

After the discovery of microRNA in 1993,[50]RNA interference (RNAi) has been used to silence an organism's genes.[51] By modifying an organism to express mircoRNA targeted to its endogenous genes, researchers have been able to knockout or partially reduce gene function in a range of species. The ability to partially reduce gene function has allowed the study of genes that are lethal when completely knocked out. Other advantages of using RNAi include the availability of inducible and tissue specific knockout.[52] In 2007 microRNA targeted to insect and nematode genes was expressed in plants, leading to suppression when they fed on the transgenic plant, potentially creating a new way to control pests.[53] Targeting endogenous microRNA expression has allowed further fine tuning of gene expression, supplementing the more traditional gene knock out approach.[54]

Genetic engineering has been used to produce proteins derived from humans and other sources in organisms that normally cannot synthesize these proteins. Human insulin-synthesising bacteria were developed in 1979 and were first used as a treatment in 1982.[55] In 1988 the first human antibodies were produced in plants.[56] In 2000 Vitamin A-enriched golden rice, was the first food with increased nutrient value.[57]

As not all plant cells were susceptible to infection by A. tumefaciens other methods were developed, including electroporation, micro-injection[58] and particle bombardment with a gene gun (invented in 1987).[59][60] In the 1980s techniques were developed to introduce isolated chloroplasts back into a plant cell that had its cell wall removed. With the introduction of the gene gun in 1987 it became possible to integrate foreign genes into a chloroplast.[61]

Genetic transformation has become very efficient in some model organism. In 2008 genetically modified seeds were produced in Arabidopsis thaliana by simply dipping the flowers in an Agrobacterium solution.[62] The range of plants that can be transformed has increased as tissue culture techniques have been developed for different species.

The first transgenic livestock were produced in 1985,[63] by micro-injecting foreign DNA into rabbit, sheep and pig eggs.[64] The first animal to synthesise transgenic proteins in their milk were mice,[65] engineered to produce human tissue plasminogen activator.[66] This technology was applied to sheep, pigs, cows and other livestock.[65]

In 2010 scientists at the J. Craig Venter Institute announced that they had created the first synthetic bacterial genome. The researchers added the new genome to bacterial cells and selected for cells that contained the new genome. To do this the cells undergoes a process called resolution, where during bacterial cell division one new cell receives the original DNA genome of the bacteria, whilst the other receives the new synthetic genome. When this cell replicates it uses the synthetic genome as its template. The resulting bacterium the researchers developed, named Synthia, was the world's first synthetic life form.[67][68]

In 2014 a bacteria was developed that replicated a plasmid containing an unnatural base pair. This required altering the bacterium so it could import the unnatural nucleotides and then efficiently replicate them. The plasmid retained the unnatural base pairs when it doubled an estimated 99.4% of the time.[69] This is the first organism engineered to use an expanded genetic alphabet.[70]

In 2015 CRISPR and TALENs was used to modify plant genomes. Chinese labs used it to create a fungus-resistant wheat and boost rice yields, while a U.K. group used it to tweak a barley gene that could help produce drought-resistant varieties. When used to precisely remove material from DNA without adding genes from other species, the result is not subject the lengthy and expensive regulatory process associated with GMOs. While CRISPR may use foreign DNA to aid the editing process, the second generation of edited plants contain none of that DNA. Researchers celebrated the acceleration because it may allow them to "keep up" with rapidly evolving pathogens. The U.S. Department of Agriculture stated that some examples of gene-edited corn, potatoes and soybeans are not subject to existing regulations. As of 2016 other review bodies had yet to make statements.[71]

In 1976 Genentech, the first genetic engineering company was founded by Herbert Boyer and Robert Swanson and a year later and the company produced a human protein (somatostatin) in E.coli. Genentech announced the production of genetically engineered human insulin in 1978.[72] In 1980 the U.S. Supreme Court in the Diamond v. Chakrabarty case ruled that genetically altered life could be patented.[73] The insulin produced by bacteria, branded humulin, was approved for release by the Food and Drug Administration in 1982.[74]

In 1983 a biotech company, Advanced Genetic Sciences (AGS) applied for U.S. government authorization to perform field tests with the ice-minus strain of P. syringae to protect crops from frost, but environmental groups and protestors delayed the field tests for four years with legal challenges.[75] In 1987 the ice-minus strain of P. syringae became the first genetically modified organism (GMO) to be released into the environment[76] when a strawberry field and a potato field in California were sprayed with it.[77] Both test fields were attacked by activist groups the night before the tests occurred: "The world's first trial site attracted the world's first field trasher".[76]

The first genetically modified crop plant was produced in 1982, an antibiotic-resistant tobacco plant.[78] The first field trials of genetically engineered plants occurred in France and the USA in 1986, tobacco plants were engineered to be resistant to herbicides.[79] In 1987 Plant Genetic Systems, founded by Marc Van Montagu and Jeff Schell, was the first company to genetically engineer insect-resistant plants by incorporating genes that produced insecticidal proteins from Bacillus thuringiensis (Bt) into tobacco.[80]

Genetically modified microbial enzymes were the first application of genetically modified organisms in food production and were approved in 1988 by the US Food and Drug Administration.[81] In the early 1990s, recombinant chymosin was approved for use in several countries.[81][82] Cheese had typically been made using the enzyme complex rennet that had been extracted from cows' stomach lining. Scientists modified bacteria to produce chymosin, which was also able to clot milk, resulting in cheese curds.[83] The Peoples Republic of China was the first country to commercialize transgenic plants, introducing a virus-resistant tobacco in 1992.[84] In 1994 Calgene attained approval to commercially release the Flavr Savr tomato, a tomato engineered to have a longer shelf life.[85] Also in 1994, the European Union approved tobacco engineered to be resistant to the herbicide bromoxynil, making it the first genetically engineered crop commercialized in Europe.[86] In 1995 Bt Potato was approved safe by the Environmental Protection Agency, after having been approved by the FDA, making it the first pesticide producing crop to be approved in the USA.[87] In 1996 a total of 35 approvals had been granted to commercially grow 8 transgenic crops and one flower crop (carnation), with 8 different traits in 6 countries plus the EU.[79]

By 2010, 29 countries had planted commercialized biotech crops and a further 31 countries had granted regulatory approval for transgenic crops to be imported.[88] In 2013 Robert Fraley (Monsantos executive vice president and chief technology officer), Marc Van Montagu and Mary-Dell Chilton were awarded the World Food Prize for improving the "quality, quantity or availability" of food in the world.[89]

The first genetically modified animal to be commercialised was the GloFish, a Zebra fish with a fluorescent gene added that allows it to glow in the dark under ultraviolet light.[90] The first genetically modified animal to be approved for food use was AquAdvantage salmon in 2015.[91] The salmon were transformed with a growth hormone-regulating gene from a Pacific Chinook salmon and a promoter from an ocean pout enabling it to grow year-round instead of only during spring and summer.[92]

Opposition and support for the use of genetic engineering has existed since the technology was developed.[76] After Arpad Pusztai went public with research he was conducting in 1998 the public opposition to genetically modified food increased.[93] Opposition continued following controversial and publicly debated papers published in 1999 and 2013 that claimed negative environmental and health impacts from genetically modified crops.[94][95]

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Indianapolis, Indiana – American Diabetes Association

August 4th, 2016 9:40 am

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Diabetes is a serious problem, particularly in Indiana. It would be a difficult task to find someone who does not personally know an individual with diabetes.

Hoosiers are increasingly feeling the effects of this disease. More than 750,000 children and adults in Indiana suffer from all forms of diabetes, including type 1, type 2 and gestational. Approximately 1 in 4 of those who have diabetes does not know it. And at least 1.9 million Hoosiers are living with prediabetes, putting them at risk for type 2 diabetes in the future. Today, it is estimated that 1 in 3 children born after the year 2000 in the U.S. will develop diabetes.

If you're renewing your Indiana license plate, choose the nation's first-ever Stop Diabetes license plate and support research, education and advocacy in Indiana!

Choose the Stop Diabetes license plate when you register or renew your vehicle online or in person at any Indiana license branch. Your plate can help change the future of diabetes in Indiana.

Stay connected and informed about programs and events in Indiana. To sign up for our monthly e-newletter, please contact Beth Grant at egrant@diabetes.org.

We welcome your help.

Your involvement as an American Diabetes Association volunteer whether on a local or national level will help us expand our community outreach and impact, inspire healthy living, intensify our advocacy efforts, raise critical dollars to fund our mission, and uphold our reputation as the moving force and trusted leader in the diabetes community.

Find volunteer opportunities in our area through the Volunteer Center.

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Indianapolis, Indiana - American Diabetes Association

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Academics || Slippery Rock University

August 4th, 2016 9:40 am

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Slippery Rock University enjoys an outstanding reputation for high-quality undergraduate and graduate academic instruction, which is only achieved through the accomplishments of exceptional faculty members.

At the undergraduate level, SRU offers over 150 majors and minors, all of which are designed with your future in mind. Want a college experience built on a challenge? The Honors Program provides academically talented and exceptionally motivated students with special opportunities.

Already completed your bachelor's degree? Graduate programs at SRU are designed with you in mind. Offering more than 30 masters and two doctoral degree programs, available on campus and online, SRU's graduate programs help students get ahead and stay ahead.

Regardless of your program of choice, SRU is committed to your success. Our campus is home to state-of-the-art classrooms, hundreds of academic clubs and honorary societies, and opportunities for research and presentations. Our Career Education and Development provides students with the tools they need to succeed in a 21st century workforce.

Look no further than our SRU Success Stories for proof that monumental futures start here.

Slippery Rock University of Pennsylvania 1 Morrow Way, Slippery Rock, PA 16057, USA

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Academics || Slippery Rock University

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Diabetes News Topix

August 4th, 2016 9:40 am

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Diabetes News Topix

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