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Genetics of Longevity in Model Organisms: Debates and …

August 4th, 2016 9:42 am

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Virginia Center For Health And Wellness | RoseWellness

August 4th, 2016 9:42 am

Welcome to Rose Wellness Center - A New Approach To Treatment

At Rose Wellness Center, we believe in restoring and maintaining good health by strengthening the body's own healing power to prevent disease and overcome chronic illnesses. We strive to identify root cases and treat the patient as a whole, rather than just treating the symptoms. Each patient has a unique set of health issues and one size fits all does not work. Our practitioners create a personalized treatment plan based on health and family history as well as results from specialized diagnostic testing.

We arededicated to providing our patientsthe absolute best treatment modalities in a warm, welcoming environment.We practice integrative medicine by combining the best of conventional medicine, alternative therapies, nutritional supplements, and lifestyle changes. Our experienced practitioners havehelped thousands of patients achieve their optimum health and well-being.

Are you ready to experience what so many other patients have experienced at Rose Wellness Center - a doctor's office that understands how important your time is, how important your health is, and works hand in hand with you throughout your healing journey to optimum health and well-being.

Call us at (571)529-6699or fill the contact form to get started.

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Virginia Center For Health And Wellness | RoseWellness

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Virginia Integrative Health – Medical Centers – 410 Pine St …

August 4th, 2016 9:42 am

Please refrain from posting non-factual information in a review otherwise you are violating laws regarding defamation and libel. Please change your review to only post factual information.

Nope, it is factual and if you think what I said in my review isn't factual, then sue me!

You may want to re-read the emails, as what you posted does not match what was written. Also, Dr. Petrie doesn't have a practice in Virginia.

Of course she doesn't....lol

Dear Ms. Preston-

It has come to our attention that you have not been complying with your required treatment plan as we outlined for your FLMA. As you know the FLMA that we completed for you was for a reduced work schedule specifically to attend weekly doctor visits, to include our office. You have not attended ANY of these weekly visits at our office since the FLMA was signed by Dr. Ginnan, despite phone calls from our office which you failed to return.

We feel ethically bound at this point to retroactively rescind your FLMA, unless you keep your weekly visits at our office starting on June 15, 2015. Please call us immediately to set up your appointment

WHO DOES SOMETHING THIS ABSURD, EVERYONE I HAVE TOLD THINKS IT SOUNDS CRAZY!!!!!!

2 weeks ago Email # 4--oh and this is patient Jay W--probably the only good review of this business!

Thanks for the great review on yelp, to my family business that was only trying to help you. Much appreciations. You and I both know that all they were trying to do was help. You were getting better when you were going there. But I guess if you didn't get exactly what you wanted. Slander! That real mature. Have a nice day God bless. Jay W.

Of course Dr. Petrie (I mean Ms. Petrie because her Chiropractic license is suspended per an email I received from the VA Medical Board) doesn't have a business which is why I received a civil summons to appear in Fairfax County Court on 7/29/15 and she is the named plaintiff suing me for $25,000 for defamation and tortious interference of business. I guess she's trying to get the $25,000 from me that she was fined by the VA Medical Board. This woman is definitely a quack and a fraud and I am contacting the media to out this scam to warn other victims!!!!!

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Virginia Integrative Health - Medical Centers - 410 Pine St ...

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FALCON v. LONG BEACH GENETICS INC | FindLaw

August 4th, 2016 9:42 am

Leslie FALCON et al., Plaintiffs and Appellants, v. LONG BEACH GENETICS, INC. et al., Defendants and Respondents.

Plaintiffs and appellants Leslie Falcon, her minor daughter (at times collectively the Falcons) and Michael Patterson appeal from a summary judgment in favor of defendants and respondents Long Beach Genetics, Inc. (LBG), Esoterix, Inc. (Esoterix), and Laboratory Corporation of America (LabCorp) on plaintiffs' second amended complaint for negligence arising out of an erroneous deoxyribonucleic acid (DNA) test result used to determine minor's paternity. Plaintiffs advance several arguments as to why the trial court erred in granting summary judgment, but we need only decide whether the Civil Code section 47, subdivision (b) litigation privilege (the section 47(b) privilege or the litigation privilege) bars the action and whether the trial court abused its discretion by denying plaintiffs leave to amend. Because defendants' alleged conduct on which plaintiffs rely falls within the section 47(b) privilege, we conclude the trial court did not err in granting summary judgment, nor did it err by denying leave to amend the complaint. Accordingly, we affirm the judgment.

FACTUAL AND PROCEDURAL BACKGROUND

We set out the undisputed material facts as ascertained from the parties' moving and opposing papers (see Guz v. Bechtel National, Inc. (2000) 24 Cal.4th 317, 327) and state other facts and draw inferences from them in the light most favorable to plaintiffs. (Code Civ. Proc., 437c, subd. (c); Aguilar v. Atlantic Richfield Co. (2001) 25 Cal.4th 826, 843 (Aguilar).) Having said this, we are compelled to note the difficulty we have had identifying the evidence supporting plaintiffs' claimed disputes as to defendants' enumerated material facts pertaining to the section 47(b) privilege. Plaintiffs' opposing separate statements largely contain argumentative assertions in response to each listed fact, unsupported by the cited evidence.1 And, much of plaintiffs' evidence is directed to their assertion that LBG was not a licensed healthcare provider in the relevant time period, which is not relevant to the section 47(b) privilege issue. In that respect, plaintiffs' opposing separate statements are of little evidentiary value. (Cf. Tucker Land Co. v. State of California (2001) 94 Cal.App.4th 1191, 1201 [supplemental proffer of undisputed material facts of no evidentiary value where the facts were not supported by specific references to pages and lines in the depositions and cited exhibits].)

To further complicate review, plaintiffs make numerous factual assertions in their briefs without record citation. Accordingly, our review of the facts is also hindered by their failure to provide citations to the record that comply with California Rules of Court, rule 8.204(a)(1)(C). We are entitled to disregard such unsupported factual assertions even on de novo review of a summary judgment. (See Mueller v. County of Los Angeles (2009) 176 Cal.App.4th 809, 816, fn. 5 [The claimed existence of facts that are not supported by citations to pages in the appellate record, or not appropriately supported by citations, cannot be considered by this court.]; Stockinger v. Feather River Community College (2003) 111 Cal.App.4th 1014, 1025.)

LBG is a laboratory that conducted DNA paternity testing until 2005, when it was acquired by LabCorp. In the fall of 2003, Leslie Falcon and Patterson scheduled a free paternity test with the County of San Diego (County) to confirm that minor was Patterson's child. On September 26, 2003,2 County commenced a paternity proceeding in the San Diego County Superior Court entitled County of San Diego v. Michael Patterson (Super.Ct.S.D.County, 2004, No. DF177011). In connection with that proceeding, Patterson agreed to provide a genetic specimen for testing on October 30, 2003, which would be delivered to LBG for testing. LBG's testing location was at the superior court in downtown San Diego, and its family relationship testing was performed as part of its contractual relationship with County. It collected DNA samples from Patterson and the Falcons in order to assist County in determining minor's paternity.

In November 2003, LBG issued test results excluding Patterson as minor's biological father and mailed it to both parents. The test results were accompanied by a declaration of LBG custodian of records Christine D'Autremonte, certifying the records. On January 30, 2004, County sent Patterson a letter informing him that the blood test results revealed he was not minor's father. The test results, however, were erroneous, as they were based on the DNA markers of someone other than Patterson. Leslie Falcon did not discover the error until February 2008, in connection with her application to reopen minor's paternity case.

In November 2009, the Falcons sued defendants for negligence. The judicial council form complaint alleged that defendants negligently concluded and thereafter via declaration testimony informed the San Diego Superior Court and Plaintiffsthat through their DNA tests, which were 99.99 [percent] accurate[minor] was not the daughter of her actual father Michael Patterson, causing damage in November 2003. The Falcons further alleged they did not suspect, nor were they able to discover this error until the Defendant conducted further DNA tests in February 2008 and that the negligence caused and continues to cause both economic and non-economic damages to the Plaintiffs. Patterson was added as a plaintiff in July 2010.

Defendants moved for summary judgment and alternatively summary adjudication of issues. They argued (1) plaintiffs' claims were barred by the litigation privilege; (2) defendants owed no duty to plaintiffs; and (3) the complaint was barred by the one-year statute of limitations under the Medical Injury Compensation Reform Act (MICRA)3 and thus failed to state facts sufficient to constitute a cause of action. As to Patterson, defendants argued that even if the MICRA one-year limitations period did not apply, his claim was barred by the two-year general negligence statute of limitations.

Plaintiffs opposed the motion, filing separate but largely identical papers. In part, plaintiffs argued the section 47(b) privilege did not apply to LBG's negligent performance of the first paternity test and defendants owed a legal duty to plaintiffs as intended third party beneficiaries of the contract between County and LBG.4 Neither Patterson nor Leslie Falcon submitted a declaration in support of the motion. Instead, in their separate statements they cited evidence submitted by defendants, and later supplemented their showing with defendants' responses to requests for admissions. Plaintiffs lodged foreign authorities including Berman v. Laboratory Corporation of America (Okla.2011) 268 P.3d 68 (Berman), in which the Oklahoma Supreme Court held a plaintiff's negligence claim was not barred by an Oklahoma absolute privilege for communications made during or preliminary to a judicial proceeding, and LabCorp owed that plaintiff, a parent seeking to prove her child's paternity, a duty to conduct accurate DNA testing ordered by Oklahoma's Department of Human Services for child support purposes. (Id. at pp. 7172.)

At about the same time, Patterson applied ex parte to file a third amendment to the complaint to add a claim for punitive damages. He sought to allege that LabCorp had retested Falcon and Patterson's DNA in 2008 at the request of DCSS, but did not inform Falcon or Patterson until 2010, and further that LabCorp did not integrate LBG's data after its merger with LBG, which caused LabCorp's cross-referencing system to fail in 2007 to recognize the 2003 testing error. Patterson sought to allege that these failures constituted gross negligence warranting punitive damages. The trial court set a hearing on the motion for March 2, 2012.

Plaintiffs thereafter neglected to timely file their motion for leave to amend, and Patterson again sought ex parte an order shortening time to file the motion. In the amended pleading, Patterson additionally sought to challenge LBG's assertion it was a licensed health care provider for purposes of applying the MICRA statute of limitations, claiming LBG withheld evidence that proved otherwise. The trial court denied Patterson's request to shorten time and scheduled the motion for June 15, 2012, after the summary judgment hearing.

At oral argument on defendants' summary judgment motion, counsel argued extensively about the existence of litigation, the parties' knowledge of County's paternity proceeding, and their motivation for going to County for blood testing. The court asked counsel to focus on the connection between the DNA test and County's proceeding, and Patterson's counsel represented that the paternity test was a free service offered by County performed without any reference to MediCal or any paternity action. When pressed, however, to identify the record evidence of that assertion, counsel could not, and eventually offered to supplement her showing with materials from DCSS. The Falcons' counsel asked the court to allow them to amend the complaint to represent the facts, that the negligent gravamen of this, or the gravamen is the negligent conduct, not the noncommunicative conduct [sic]. Plaintiffs also sought to amend the complaint to allege that defendants had conducted a retest in 2007 but did not inform Patterson until 2010, breaching its contract with County and violating Family Code section 7552.

Ruling Berman, supra, 268 P.3d 68 was directly at odds with California authority, specifically Ramalingam v. Thompson (2007) 151 Cal.App.4th 491 and Gootee v. Lightner (1990) 224 Cal.App.3d 587, the trial court granted summary judgment in defendants' favor. Taking judicial notice of the existence of County's proceeding, the court ruled the gravamen of plaintiffs' complaint was communicative conduct barred by the section 47(b) privilege; that LBG performed the test in connection with the paternity proceedings initiated by County and plaintiffs' alleged injuries arose from the laboratory's communication of the test results to the parties in that action. The court denied plaintiffs' request for leave to amend the complaint to allege that LBG breached its duty to notify plaintiffs of its 2008 retest results under Family Code section 7552.5 and the contract between it and County. It reasoned that the amendment was unreasonably delayed, as the Falcons had filed the action in November 2009 and Patterson was added in July 2010, but the request to amend was not made until the April 2012 summary judgment hearing. It further ruled plaintiffs could not state a viable cause of action in any event.5 Plaintiffs appeal from the ensuing judgment.

DISCUSSION

I.Summary Judgment Principles and Standard of Review

Any party may move for summary judgment in any action or proceeding if it is contended that the action has no merit or that there is no defense to the action or proceeding. (Code Civ. Proc., 437c, subd. (a).) A defendant moving for summary judgment bears the burden of persuasion that one or more elements of the cause of action in question cannot be established, or that there is a complete defense thereto. (Aguilar, supra, 25 Cal.4th at p. 850; Code Civ. Proc., 437c, subd. (p)(2).) Such a defendant bears an initial burden of production to make a prima facie showing of the nonexistence of any triable issue of material fact. (Aguilar, at p. 850.) Once the defendant meets its initial burden of production, the burden shifts to plaintiff to demonstrate the existence of a triable issue of material fact. (Id. at pp. 850851.)

On appeal, we review the record and the trial court's decision de novo, liberally construing the evidence in support of the plaintiffs as the opposing parties and resolving doubts concerning the evidence in their favor. (Coral Const., Inc. v. City and County of San Francisco (2010) 50 Cal.4th 315, 336; State of California v. Allstate Ins. Co. (2009) 45 Cal.4th 1008, 1017.) Despite this review in plaintiffs' favor, plaintiff's evidence remains subject to careful scrutiny. [Citation.] We can find a triable issue of material fact if, and only if, the evidence would allow a reasonable trier of fact to find the underlying fact in favor of the party opposing the motion in accordance with the applicable standard of proof. (King v. United Parcel Service, Inc. (2007) 152 Cal.App.4th 426, 433; see Sangster v. Paetkau (1998) 68 Cal.App.4th 151, 163 [responsive evidence that gives rise to no more than mere speculation cannot be regarded as substantial, and is insufficient to establish a triable issue of material fact].)

II.The Section 47(b) Privilege Bars Plaintiffs' Negligence Claim

A.The Section 47(b) Privilege

The section 47(b) litigation privilege provides that a publication or broadcast made as part of a judicial proceeding is privileged. (Action Apartment Assn., Inc. v. City of Santa Monica (2007) 41 Cal.4th 1232, 1241.) The usual formulation is that the privilege applies to any communication (1) made in judicial or quasi-judicial proceedings; (2) by litigants or other participants authorized by law; (3) to achieve the objects of the litigation; and (4) that [has] some connection or logical relation to the action. [Citation.] The privilege is not limited to statements made during a trial or other proceedings, but may extend to steps taken prior thereto, or afterwards. (Action Apartment, at p. 1241, quoting Silberg v. Anderson (1990) 50 Cal.3d 205, 212; see also Hawran v. Hixson (2012) 209 Cal.App.4th 256, 282; Komarova v. National Credit Acceptance, Inc. (2009) 175 Cal.App.4th 324, 336 [communications with some relation to an anticipated lawsuit are within the privilege].) And judicial or quasi-judicial proceedings are defined broadly to include all kinds of truth-seeking proceedings, including administrative, legislative and other official proceedings. (Wang v. Heck (2012) 203 Cal.App.4th 677, 684.) [T]he communication must be in furtherance of the objects of the proceeding, which is part of the requirement that the communication be connected with, or have some logical relation to, the [proceeding], i.e., that it not be extraneous to the [proceeding]. (Hawran, at pp. 282283, quoting Action Apartment, at p. 1251.)

The litigation privilege is absolute and broadly applied regardless of malice. (Jacob B. v. County of Shasta (2007) 40 Cal.4th 948, 955.) Its purposes are to afford litigants and witnesses free access to the courts without fear of being harassed subsequently by derivative tort actions, to encourage open channels of communication and zealous advocacy, to promote complete and truthful testimony, to give finality to judgments and to avoid unending litigation. (Ibid.) It promotes effective judicial proceedings by encouraging full communication with the courts. (Ibid.) Accordingly, doubts as to whether the privilege applies are resolved in its favor. (Hawran v. Hixson, supra, 209 Cal.App.4th at p. 283; Wang v. Heck, supra, 203 Cal.App.4th at p. 684.)

Despite its broad and absolute nature, the litigation privilege only protects publications and communications. Thus, a threshold issue in determining the applicability of the privilege is whether the defendant's conduct was communicative or noncommunicative The distinction between communicative and noncommunicative conduct hinges on the gravamen of the action That is, the key in determining whether the privilege applies is whether the injury allegedly resulted from an act that was communicative in its essential nature. (Rusheen v. Cohen (2006) 37 Cal.4th 1048, 10571058; see also Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at pp. 12481249.) And, if the gravamen of the action is based on a communicative act, the litigation privilege extends to noncommunicative acts that are necessarily related to the communicative conduct Stated another way, unless it is demonstrated that an independent, noncommunicative, wrongful act was the gravamen of the action, the litigation privilege applies. (Rusheen, at p. 1065; Tom Jones Enterprises, Ltd. v. County of Los Angeles (2013) 212 Cal.App.4th 1283, 1295.) The interpretation of Civil Code section 47, subdivision (b) is a pure question of law that we review independently. (Wang v. Heck, supra, 203 Cal.App.4th at p. 684.)

B.Challenges to the Elements of the Section 47(b) Privilege

Patterson contends these facts do not meet the elements of the section 47(b) privilege, that is, the existence of an underlying judicial or quasi-judicial proceeding, or the necessary communication made by litigants or other participants authorized by law, to achieve the objects of the litigation, having some connection or logical relation to the action. (See Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1241.) Specifically, Patterson maintains there is no evidence of any dispute, or that a true case with appropriate pleadings were [sic] filed prior to testing, and there is no evidence he and Falcon had initiated the case or were participating in litigation. He suggests plaintiffs did not need to engage in a paternity fight because they were both engaged and happy custodial parents, and the DNA test had no connection or logical relation to the action because he was not refusing to support his child.

Falcon includes similar arguments in her reply brief on appeal. In part, relying on County of San Diego v. Gorham (2010) 186 Cal.App.4th 1215, a case not involving the section 47(b) privilege, she argues service of summons and complaint of County's action was a prerequisite to any determination that plaintiffs were litigants in that action, and there was no personal jurisdiction over the parties, violating their rights to due process. She also argues the plaintiffs underwent testing of their own free will and did not respond to any court order or ask to be involved in any litigation.

These contentions are meritless. The trial court properly took judicial notice of the existence and pendency of County's superior court proceeding against Patterson (Evid.Code, 452, subd. (d) [judicial notice proper of records of any court of record of any state of the United States]; People v. Lee (2011) 51 Cal.4th 620, 651, fn. 20), and there is no dispute Patterson consented to the defendants' DNA testing. As we explain below, Patterson's stipulation constituted a general appearance in the action, conferring jurisdiction over his person. DNA testing was sought to assist County in the then pending proceeding to ascertain minor's paternity; defendants' acts in conducting the test and communicating its results plainly furthered that goal, and had some logical relation to the action. (Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1241.) None of the authorities relied upon by Patterson and the Falcons support the proposition that application of the section 47(b) privilege requires a party or participant initiate or be cognizant of pending or contemplated litigation. More specific to this case, plaintiffs' arguments give us no basis to conclude a party's willingness to undergo DNA testing, where that testing is performed under contract with a County for purposes of a pending paternity proceeding, somehow negates any connection or logical relation between the test and the paternity action.6

C.Plaintiffs Allege Their Injury Resulted from the Defendant's Communication of the Erroneous Test Results to County

Characterizing the trial court's decision as inequitable, illogical, and contrary to the Legislature's intent in enacting Civil Code section 47, subdivision (b), plaintiffs contend the litigation privilege cannot apply to a free paternity test conducted negligently merely because the erroneous test results were communicated to County and the parties. They argue: The litigation privilege was intended to protect expert witnesses from being sued for their opinions, for the testimony they offer in court. But DNA paternity testing is mathematical, a test akin to throwing a switch and comparing two printed documents to determine if the marks on the two documents are identical. Plaintiffs assert the entire purpose of defendants' paternity test is to provide the court and the parents definitive proof of a child's father, and thus the distinction between the performance of the test itself and the inevitable communication of its results becomes meaningless, and would leave parties harmed by a negligently performed test without any legal remedy.

As stated above, plaintiffs squarely allege the basis for negligence liability is that defendants negligently concluded and thereafter via declaration testimony informed the San Diego Superior Court and Plaintiffs through their DNA tests [that minor] was not the daughter of her actual father Michael Patterson (Italics added.) Plaintiffs allege that this negligence caused damage in November 2003. Plaintiffs' allegations demonstrate their injuries resulted from an act that was communicative in its essential nature. (Rusheen v. Cohen, supra, 37 Cal.4th at pp. 10571058.) Accordingly, the litigation privilege extends not only to the defendants' communication of the genetic test results, but the noncommunicative act of the DNA testing itself that is necessarily related to the communication. (Id. at p. 1065.)

Under settled summary judgment standards, we are limited to assessing those theories alleged in the plaintiffs' pleadings. (Conroy v. Regents of University of Cal. (2009) 45 Cal.4th 1244, 1250 [the materiality of a disputed fact is measured by the pleadings, which set the boundaries of the issues to be resolved at summary judgment]; County of Santa Clara v. Atlantic Richfield Co. (2006) 137 Cal.App.4th at 292, 332; Laabs v. City of Victorville (2008) 163 Cal.App.4th 1242, 12531258 & fn. 7; Oakland Raiders v. National Football League (2005) 131 Cal.App.4th 621, 648.) The burden of a defendant moving for summary judgment only requires that he or she negate plaintiff's theories of liability as alleged in the complaint. A moving party need not refute liability on some theoretical possibility not included in the pleadings. [Citation.] [A] motion for summary judgment must be directed to the issues raised by the pleadings. The [papers] filed in response to a defendant's motion for summary judgment may not create issues outside the pleadings and are not a substitute for an amendment to the pleadings. (County of Santa Clara, at p. 332.) The function of the pleadings in a motion for summary judgment is to delimit the scope of the issues: the function of the affidavits or declarations is to disclose whether there is any triable issue of fact within the issues delimited by the pleadings. (FPI Development, Inc. v. Nakashima (1991) 231 Cal.App.3d 367, 381.) [A] plaintiff wishing to rely upon unpleaded theories to defeat summary judgment must move to amend the complaint before the hearing. (Oakland Raiders, at p. 648; see also County of Santa Clara, at p. 333; Laabs. v. City of Victorville, at p. 1257.)

Even if plaintiffs had specifically alleged that the basis for their claim was defendants' negligent testing, and not the communication of the test results via D'Autremonte's declaration, our conclusion would not change. The summary judgment evidence is undisputed that the test results were communicated to County and the parties for the purpose of County's paternity proceeding. Thus, defendants' testing and its communication to County are necessarily linked, and the injury would not have occurred but for communication of the results in the legal proceeding.

We are not convinced by plaintiffs' arguments otherwise. The distinction between an expert's opinion testimony, which plaintiffs assert is subject to the privilege, and underlying negligently performed scientific testing, which assertedly should fall outside the privilege, is simply not recognized by California authorities applying the section 47(b) privilege in analogous contexts. For example, in Block v. Sacramento Clinical Labs, Inc. (1982) 131 Cal.App.3d 386, the Court of Appeal held the litigation privilege applied to an action for professional negligence against a toxicologist for a negligently performed blood analysis provided to the district attorney to determine whether criminal charges were warranted. (Id. at pp. 387388.) The toxicologist had erred in his calculations of the amount of baby aspirin a baby would have ingested based on the salicylate concentration in its blood. (Id. at p. 388.) The plaintiff argued the toxicologist was liable if his lack of ordinary care caused foreseeable injury to her economic interests: [O]nce [the defendant] had made his erroneous preliminary determination that the child had ingested a large number of aspirins immediately prior to her death, his purpose was to provide that information to the District Attorney and to the court so that they would rely thereon. (Id. at p. 392.) The plaintiff argued there was no question her injuries were clearly foreseeable and in fact foreseen by the defendant. (Ibid.)

The Court of Appeal held this theory place[d] [the defendant's] communication of the report to the district attorney and, later, his testimony in the criminal proceeding, at the heart of the claim of liability Whether the matter be characterized as the publication of a negligently prepared report or the negligent publication of the report, plaintiff finds the duty upon which her theory of negligence relies in the foreseeable consequences of publication of the report in or related to the judicial proceeding. (Block v. Sacramento Clinical Labs, Inc., supra, 131 Cal.App.3d at pp. 392393.) Any other approach would substantially defeat the purpose of [the] privilege. (Id. at p. 394.) The court observed that the plaintiff at oral argument sought to escape the privilege by characterizing the action as arising out of the defendant's negligent conduct alone. (Id. at p. 393, fn. 10.) It concluded, however, that under any cognizable theory of duty, the negligent calculation formed the basis of [defendant's] communication and was privileged. (Ibid.) Block held the defendant toxicologist's conduct fell within the litigation privilege; he performed and communicated the calculations on the request of the district attorney in furtherance of its investigation whether there was probable cause to initiate criminal charges relating to the infant's death, and thus the conduct had some relation to proposed and seriously considered criminal litigation. (Id. at pp. 393394.)

More recently, in Wang v. Heck, supra, 203 Cal.App.4th 677, the appellate court affirmed a summary judgment on grounds the section 47(b) privilege barred a plaintiff motorist's negligence claim against a neurologist who had filled out a medical evaluation form for a patient that was relied upon by the Department of Motor Vehicles (DMV) to reinstate the patient's license. (Id. at pp. 679, 681.) Like plaintiffs in the present case, the plaintiff in Wang sought to avoid the privilege's application by arguing the negligence was not the completion of the DMV medical evaluation form, but the neurologist's treatment of the patient before that time and her failure to warn the patient not to drive. (Id. at pp. 685, 686.) The Court of Appeal rejected that argument. It reasoned none of the plaintiff's causes of action could stand without relying on the neurologist's completion of the DMV medical evaluation form. (Id. at p. 684.) It pointed out that the neurologist was a participant authorized by law to complete the form, and [a]lthough [the neurologist] did not complete the DMV evaluation form for purposes of testifying in judicial proceedings, the form was used in a truth-seeking proceeding[,] that is, it was used in the DMV administrative hearing in order for the DMV hearing officer to determine whether to reinstate the patient's license. (Id. at p. 685.) Further, the form was completed to achieve the object of the DMV hearing: to determine the patient's fitness for driving. (Ibid.) The court stated: [I]t is clear that [the neurologist's] conduct prior to completing the DMV evaluation form was the basis of her communication in completing the form. Although appellants attempt to characterize their claim as medical negligence by failing to warn [the patient] not to drive, the basis of their complaint is [the neurologist's] statement on the DMV medical evaluation form that [the patient] could drive safely. (Id. at p. 686.) In concluding the gravamen of the plaintiff's action was communicative, the Wang court's focus was not on the neurologist's testimonial function at a judicial proceeding, but the use of the neurologist's report in connection with that proceeding. As the court in Wang recognized (id. at pp. 686687), our high court emphasizes the importance of the litigation privilege's absolute protection of access to the courts, even despite its costs: [It] is desirable to create an absolute privilege not because we desire to protect the shady practitioner, but because we do not want the honest one to have to be concerned with [subsequent derivative] actions [Citations.] [W]hen there is a good faith intention to bring a suit, even malicious publications are protected as part of the price paid for affording litigants the utmost freedom of access to the courts. (Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1244.)

Here, as in the above cases, the defendants' DNA test was prepared for the purpose of determining minor's paternity in connection with County's paternity proceeding, and transmitted to and used by County for that purpose. This result does not, as plaintiffs argue, afford[] absolute immunity to DNA paternity testers (Some capitalization omitted.) It protects only those persons or entities conducting tests in connection with or contemplation of litigation within the meaning of the section 47(b) litigation privilege, a result compelled by the breadth of the privilege and its purposes. In reaching our conclusion, we necessarily decline plaintiffs' invitation to adopt the reasoning of the Oklahoma Supreme Court in Berman, supra, 268 P.3d 68.7

Because the conduct relied upon by plaintiffs falls within the section 47(b) litigation privilege, we need not address plaintiffs' arguments concerning whether defendants owed them a duty of care.

III.Patterson's Due Process Argument

Patterson contends he and Falcon were denied their federal due process rights under the Fourteenth Amendment of the U.S. Constitution because they were never served with the summons and complaint pertaining to County's paternity proceeding, and were never apprised of the pendency of the action. This argument fails for several reasons.

First, such a theory was not pleaded in the operative complaint. The sole cause of action in plaintiffs' second amended complaint is general negligence, and thus under the above-summarized summary judgment standards, we are limited to assessing that claim. Plaintiffs did not allege a cause of action for violation of any federal civil rights, which would rest on an entirely different theor[y] of recovery (Laabs v. City of Victorville, supra, 163 Cal.App.4th at p. 1257) and is not fairly encompassed in the second amended complaint. As a consequence, Patterson's due process arguments do not raise triable issues of material fact for a jury on plaintiffs' negligence cause of action.

Second, plaintiffs do not provide record citations to support the assertions made in their opening appellate briefs concerning service of any summons and complaint or their lack of knowledge of County's pending paternity proceeding.8 Third, plaintiffs' opposing summary judgment evidence cited in the trial courtnamely, the declaration of LBG's general manager and laboratory director John Taddie, Ph.D., the request for dismissal of County's 2003 proceeding, and Patterson's stipulation regarding DNA parentage test and order thereondo not provide evidentiary support for plaintiffs' factual statements.

Finally, the summary judgment record establishes that on October 30, 2003, Patterson executed a stipulation to undergo DNA testing, which was filed in County's proceeding on November 5, 2003. While a court must have personal jurisdiction over parties (see County of San Diego v. Gorham, supra, 186 Cal.App.4th at pp. 12261227), it is long settled that a party's consent is a proper basis to confer personal jurisdiction over the party. (See In re Vanessa Q. (2010) 187 Cal.App.4th 128, 135.) In short, Patterson's execution of the stipulation constituted a general appearance in the matter, which operated as a consent to jurisdiction of his person. (See Code Civ. Proc., 410.50, subd. (a); e.g., City of Riverside v. Horspool (2014) 223 Cal.App.4th 670, 679 [general appearance occurs when the defendant takes part in the action or in some manner recognizes the authority of the court to proceed]; Dial 800 v. Fesbinder (2004) 118 Cal.App.4th 32, 52 [same].) Any of these grounds compels us to reject Patterson's due process argument.

IV.Leave to Amend

The Falcons contend that even if the section 47(b) privilege applies, the trial court reversibly erred by denying their oral motion for leave to amend during the summary judgment hearing. They maintain plaintiffs had timely sought leave to amend in 2011 and 2012 to allege additional claims stemming from the respondent's subsequent cover up of its negligence. Patterson similarly claims plaintiffs sought leave to amend in January 2012 to include allegations of negligent acts occurring in 2007 and 2008 that delayed Patterson's 2010 discovery that minor was his daughter. Plaintiffs argue they made every possible effort to timely amend the complaint, and did not unreasonably delay in requesting leave to amend.

A.Legal Principles

A trial court has wide discretion to allow the amendment of pleadings, and generally courts will liberally allow amendments at any stage of the proceeding. (Atkinson v. Elk Corp. (2003) 109 Cal.App.4th 739, 761.) On a motion for summary judgment [w]here the complaint is challenged and the facts indicate that a plaintiff has a good cause of action which is imperfectly pleaded, the trial court should give the plaintiff an opportunity to amend. (Soderberg v. McKinney (1996) 44 Cal.App.4th 1760, 1773.) But if the proposed amendment fails to state a cause of action, it is proper to deny leave to amend. (Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at p. 652.)

Further, unwarranted delay in seeking leave to amend may be considered by the trial court when ruling on a motion for leave to amend (Huff v. Wilkins (2006) 138 Cal.App.4th 732, 746), and appellate courts are less likely to find an abuse of discretion where, for example, the proposed amendment is offered after long unexplained delay or where there is a lack of diligence (Hulsey v. Koehler (1990) 218 Cal.App.3d 1150, 1159.) Thus, when a plaintiff seeks leave to amend his or her complaint only after the defendant has mounted a summary judgment motion directed at the allegations of the unamended complaint, even though the plaintiff has been aware of the facts upon which the amendment is based, [i]t would be patently unfair to allow plaintiffs to defeat [the] summary judgment motion by allowing them to present a moving target unbounded by the pleadings. (Melican v. Regents of University of California (2007) 151 Cal.App.4th 168, 176; but see Laabs v. City of Victorville, supra, 163 Cal.App.4th at p. 1257, fn. 6 [if at the hearing of a summary judgment motion a party finds his pleading inadequate, the court may and should permit him to amend].)

And, under the sham pleading doctrine, the trial court may disregard amendments that omit harmful allegations in the original complaint or add allegations inconsistent with it. (State of California ex rel. Metz v. CCC Information Systems, Inc. (2007) 149 Cal.App.4th 402, 412; Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at pp. 652652 [applying sham pleading doctrine to request for leave to amend in summary judgment context].)

B.Plaintiffs Have Not Demonstrated the Trial Court Abused its Discretion in Denying Leave to Amend

Plaintiffs have not shown the trial court manifestly abused its discretion in denying them leave to amend. They argue they timely sought to allege specific further negligent acts on LabCorp's part in 2007 and 2008 to support an additional claim for negligence or further gross negligence. These acts, which plaintiffs do not further describe in their opening briefs, presumably are defendants' asserted failure to send the parties copies of the test results from additional DNA testing conducted in 2008. But the trial court's decision was not limited to unreasonable delay and plaintiffs do not address the remainder of the court's ruling, which addressed the requirements of Family Code section 7552.59 and the existence of a legal duty of care to notify the parties of the additional test results (see footnote 5, ante). Absent such an analysis, plaintiffs have not shown to this court, as they must (Dey v. Continental Central Credit (2008) 170 Cal.App.4th 721, 731), that the court abused its discretionmade a ruling that exceeds the bounds of reason or is legally incorrect (ibid.)in concluding plaintiffs could not state a viable cause of action for negligence.

Nor do plaintiffs explain on appeal how their new theorythat they suffered damage by the lack of knowledge of the 2008 DNA testingis consistent with the complaint's allegations that plaintiffs did not suspect, nor were they able to discover this error until the Defendant conducted further DNA tests in February 2008 or their admissions in their summary judgment papers that Leslie Falcon discovered the error in February 2008, and Patterson was served with another lawsuit relating to minor's paternity in or around April or May 2008. Plaintiffs may not discard factual allegations of a prior complaint, or avoid them by contradictory averments, in a superseding, amended pleading, and must explain inconsistencies between the prior and proposed pleading. (Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at p. 653; see also Vallejo Development Co. v. Beck Development Co. (1994) 24 Cal.App.4th 929, 946.) The trial court could reasonably conclude that any amendment was inconsistent with plaintiffs' theory of the case, and reject it on that basis.

DISPOSITION

The judgment is affirmed.

FOOTNOTES

1.For example, in their opposing summary judgment separate statements and opening appellate briefs, the Falcons and Patterson assert they had no knowledge of the 2003 paternity proceeding at issue in this matter and Patterson was not served with any summons or complaint. In response to defendants' assertion that the DNA test took place within the confines of the 2003 paternity proceeding, plaintiffs assert: The 2003 paternity test was requested without any knowledge by the parties of said lawsuit, it was not within the confines of any litigation brought or known by the tested parties. [San Diego County Department of Child Support Services (DCSS)] did not serve the tested party any Summons or Complaint. Setting aside the fact that plaintiffs provide no authority for the proposition that a plaintiff must either initiate or have knowledge of pending litigation to defeat the section 47(b) litigation privilege, the evidence cited for this propositionthe declaration of LBG's general manager and laboratory director John Taddie, Ph.D., the request for dismissal of the 2003 proceeding against Patterson, and the November 2003 stipulation regarding DNA parentage test and order thereon executed by Pattersondoes not support these assertions.

2.The September 26, 2003 filing date of County's proceeding is reflected in LabCorp's request for judicial notice of the court file in County's paternity action, as well as in a page from the register of actions attached as an exhibit to counsel's declaration in support of LabCorp's motion for summary judgment. In its order granting summary judgment and judgment thereon, the trial court states that County's paternity proceeding was initiated in September 2003.

3.MICRA applies to any claim of professional negligence against a health care provider. [Citations.] A health care provider is any person licensed or certified pursuant to Division 2 (commencing with Section 500) of the Business and Professions Code (de Mercado v. Superior Court (2007) 148 Cal.App.4th 711, 714.) Code of Civil Procedure section 340.5 provides in part: In an action for injury or death against a health care provider based upon such person's alleged professional negligence, the time for the commencement of action shall be three years after the date of injury or one year after the plaintiff discovers, or through the use of reasonable diligence should have discovered, the injury, whichever occurs first.

4.Plaintiffs also argued defendants' motion should be denied due to defense counsel's unethical misconduct in withholding documents concerning LBG's licensed healthcare provider status and MICRA's one-year limitations period did not apply to plaintiffs' claims because LBG was not a licensed healthcare provider in 2003. Patterson additionally argued there was a factual dispute over whether he knew or reasonably should have known about LBG's 2003 testing error. These points are not pertinent to application of the section 47(b) privilege.

5.The judgment states: Family Code section 7552.5 requires the County to serve on all parties a copy of the results of all genetic tests performed under Section 7552 or 7558 no later than 20 days prior to any hearing in which the genetic test results may be admitted into evidence. As an initial matter, plaintiffs do not identify any hearing that triggered the duty to serve LabCorp's revised conclusion. In addition, the statute imposes the duty to serve on the County. The County hired LBG/LabCorp to provide services in connection with paternity litigation and to assist the court in rendering a judgment in the matter. LabCorp's contractual assumption of the County's obligation under section 7552.5 does not create a duty of care on the part of LabCorp to plaintiffs. (Cf. Felton v. Schaeffer (1991) 229 Cal.App.3d 229.) Likewise, the fact that LabCorp may have contractually agreed to perform the County's obligation to serve plaintiffs with test results does not tend to establish they were intended third party beneficiaries.

6.At oral argument, the appellants repeated an argument raised for the first time in Patterson's reply brief: that LabCorp cannot meet the third and fourth prongs of the litigation privilege because its negligence was in testing the DNA of an unknown man. They contend that as a result, LabCorp's report of test results, even if a communication made in connection with litigation, neither was made to achieve the objects of the litigation nor has any connection or logical relation to the action. (See Action Apartment Assn., Inc. v. City of Santa Monica,supra, 41 Cal.4th at p. 1241; Silberg v. Anderson,supra, 50 Cal.3d at p. 212; see also Rusheen v. Cohen,supra, 37 Cal.4th at p. 1057 [communications with some relation to judicial proceedings are absolutely immune from tort liability].) This argument, if accepted, would make application of the litigation privilege turn not on the connection between the communication and the litigation but on the type or nature of the underlying negligence. We decline to adopt such an unworkable test, which would contradict the law in California that the litigation privilege is to be construed broadly to afford litigants and witnesses [citation] the utmost freedom of access to the courts without fear of being harassed subsequently by derivative tort actions' (Action Apartment, at p. 1241) and that doubts are to be resolved in favor of applying the privilege. (Hawran v. Hixson,supra, 209 Cal.App.4th at p. 283.) LabCorp's DNA testing and communication of results, regardless of the nature of LabCorp's error, was done for the purpose of determining the minor's paternity in connection with County's proceeding, and thus was in furtherance of the objects of, and had some functional relation to, that proceeding. (Action Apartment, at p. 1251 [communication must be in furtherance of the objects of the proceeding and not be extraneous to it]; Rusheen v. Cohen, at p. 1057; Hawran v. Hixson, at pp. 282283 [connection or logical relation for the section 47b privilege must be a functional connection; a necessary or useful step in the litigation process].)

7.The Oklahoma Supreme Court's discussion in Berman,supra, 268 P.3d 68, makes clear that the parameters of Oklahoma's statutory absolute privilege to communications made during or preliminary to a proposed proceeding (12 O.S.2001 1443.1), are different from California's section 47(b) privilege, which applies to all torts except malicious prosecution. (Action Apartment Assn., Inc. v. City of Santa Monica,supra, 41 Cal.4th at pp. 12411242). The Oklahoma privilege bars defamation actions, and had been extended to claims for intentional infliction of emotional distress when based on the same factual allegations as the defamation claim. (Berman, 268 P.3d at p. 71.) The Oklahoma Supreme Court pointed out that the case at hand did not involve a claim for defamation, and further, that the plaintiff's claims were not based on evidence relevant to the paternity and DNA sample of the alleged father, but on evidence that LabCorp tested the DNA of a completely different man, thus the communication was based on the evidence of a stranger to this case. (Ibid.) The court concluded the negligence claim arose not out of the laboratory's communication to the Oklahoma Department of Human Services, but out of its conduct in the performance of its duties. (Id. at pp. 7172.) Observing that the importance of reliable and accurate DNA test results cannot be overstated, the Oklahoma Supreme Court went on to hold, as a matter of first impression, that LabCorp owed a duty to the plaintiff to perform accurate DNA testing for purposes of determining the paternity of her child. (Id. at p. 72.)

8.The Falcons argue: Unbeknownst to appellants at the time they accessed the free paternity test, due to utilizing MediCal for the birthing costs of minor appellant , the County Welfare Department automatically notified, which in turn prompted, the County Department of Child Support Services to initiate a support case for [minor]. This action was done electronically without notice to Falcon or Patterson; neither party knew of or expected any DCSS action to be filed. Neither Falcon nor Patterson initiated any type of case, nor was either party served a Summons or Complaint prior to requesting the free test. Moreover, neither party had any knowledge or notice of any pending case or proceeding prior to accessing the free paternity test from the county. There was no achieving the objects of the litigation as they had no intent to litigate and was [sic] not even aware any litigation existed. There was no purpose or intent to litigate for child support. Patterson makes a largely identical argument. Neither paragraph contains any citation to the record.

9.Family Code section 7552.5 provides in part: A copy of the results of all genetic tests performed under Section 7552 [genetic tests performed by approved laboratory] or 7558 [local child support agency administrative order for genetic testing] shall be served upon all parties, by any method of service authorized under Chapter 5 (commencing with Section 1010) of Title 14 of Part 2 of the Code of Civil Procedure except personal service, no later than 20 days prior to any hearing in which the genetic test results may be admitted into evidence. (Fam.Code, 7552.5, subd. (a).)

O'ROURKE, J.

WE CONCUR:McCONNELL, P.J.IRION, J.

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FALCON v. LONG BEACH GENETICS INC | FindLaw

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Human Gene Therapy

August 4th, 2016 9:42 am

Editor-in-Chief: Terence R. Flotte, MD Deputy Editor, Europe: Thierry VandenDriessche, PhD Deputy Editor, U.S.: Barry J. Byrne, MD, PhD Human Gene Therapy Editor: Guangping Gao, PhD Methods Editor: Hildegard Bning, PhD Clinical Development Editor: James M. Wilson, MD, PhD

Latest Impact Factor* is 3.755 *2014 Journal Citation Reports published by Thomson Reuters, 2015

Human Gene Therapy is the premier, multidisciplinary journal covering all aspects of gene therapy. The Journal publishes in-depth coverage of DNA, RNA, and cell therapies by delivering the latest breakthroughs in research and technologies. Human Gene Therapy provides a central forum for scientific and clinical information, including ethical, legal, regulatory, social, and commercial issues, which enables the advancement and progress of therapeutic procedures leading to improved patient outcomes, and ultimately, to curing diseases.

The Journal is divided into three parts. Human Gene Therapy, the flagship, is published 12 times per year. HGT Methods, a bimonthly journal, focuses on the applications of gene therapy to product testing and development. HGT Clinical Development, a quarterly journal, serves as a venue for publishing data relevant to the regulatory review and commercial development of cell and gene therapy products.

Human Gene Therapy was voted one of the most influential journals in Biology and Medicine over the last 100 years by the Biomedical & Life Sciences Division of the Special Libraries Association.

Human Gene Therapy, HGT Methods, and HGT Clinical Development are under the editorial leadership of Editor-in-Chief Terence R. Flotte, MD, University of Massachusetts Medical School; Deput Editor Europe Thierry VandenDriessche, PhD, Free University of Brussels (VUB); Deputy Editor U.S. Barry J. Byrne, MD, PhD,Powell Gene Therapy Center, University of Florida, College of Medicine; Human Gene Therapy Editor Guangping Gao, PhD, University of Massachusetts Medical School; Methods Editor Hildegard Bning, PhD, University of Cologne; Clinical Development Editor James M. Wilson, MD, PhD,University of Pennsylvania School of Medicine, Gene Therapy Program; and other leading investigators. View the entire editorial board.

Audience: Geneticists, medical geneticists, molecular biologists, virologists, experimental researchers, and experimental medicine specialists, among others.

Human Gene Therapy and HGT Methods provide Instant Online publication 72 hours after acceptance

The views, opinions, findings, conclusions and recommendations set forth in any Journal article are solely those of the authors of those articles and do not necessarily reflect the views, policy or position of the Journal, its Publisher, its editorial staff or any affiliated Societies and should not be attributed to any of them.

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Human Gene Therapy

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Northern Kentucky Health Department | Diabetes

August 4th, 2016 9:42 am

Are you at risk for diabetes?Diabetes control program Diabetes classes Diabetes support groups Needle disposal Eye examsFacts and figuresMore information

Are you at risk for diabetes? Twenty-five percent of Americans with diabetes dont know they have the disease. Take a diabetes risk test to learn your risk for type 2 diabetes and whether you should follow up with one of the Health Department's diabetes educators to take steps to protect your health. For more information on diabetes, contactJoan Geohegan at 859.363.2115 or Julie Shapero at 859.363.2116.

Diabetes control programThe Health Departments diabetes control program is a self-management training program for adults, and is accredited by the American Association of Diabetes Educators. The program is facilitated by a Certified Diabetes Educator/Registered Nurse and a Registered, Licensed Dietitian. The Health Department offers group sessions to help you learn to manage your diabetes. Specific information is given on healthy eating, physical activity, coping with a chronic disease and more. The program is offered in the community. Counseling is also available in Spanish upon request. For more information, please call one of our educators, Joan Geohegan, RN, BSN, CDE, at 859.363.2115 or Julie Shapero, RD, LD, at 859.363.2116.

Diabetes classes The Health Department routinely holds free classes on diabetes, with topics that include: what is diabetes, healthy eating, complications and more. The classes are led by a Registered Nurse and a Registered Dietitian. For more information, please call Joan Geohegan at 859.363.2115 or Julie Shapero at 859.363.2116.

Diabetes support groups The Health Department sponsors three adult diabetes support groups:

Dates and times are subject to change, so please contact Joan Geohegan at 859.363.2115 to confirm

Needle disposal Need to dispose of needles or other medical waste at your home? The Kentucky Department for Environmental Protection has created a fact sheet with tips on how to protect yourself and those who pick up your trash. Eye exams If you have diabetes, regular eye exams are crucial to avoid eye problems. Diabetes can lead to eye problems such as cataracts, glaucoma and retinopathy. Make sure to see your doctor as soon as possible if you have diabetes and start to experience issues with your vision.

Facts and figures

More information For more information on diabetes, please call one of our educators, Joan Geohegan, RN, BSN, CDE, at 859.363.2115 or Julie Shapero, RD, LD, at 859.363.2116.

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Northern Kentucky Health Department | Diabetes

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Longevity, how to live longer with diet, food, and dietary …

August 4th, 2016 9:42 am

Longevity Secrets, practical steps to take to have a longer life, diet, food and supplements Subscribe to a FREE Natural Healing newsletter at Physician Formulas December 15, 2015 by Ray Sahelian, M.D.

In the USA, the two major risk factors for premature death are smoking and high blood pressure. Even in middle age, adopting a healthy lifestyle can lower the risk for heart disease and premature death. A program of healthy eating, exercise and stress reduction can not only reverse some diseases -- it may actually slow down the aging process at the genetic level. The lifestyle changes affected the telomeres -- little caps on the end of the chromosomes that carry the DNA, a team at the University of California, San Francisco reported in December 2013.

Supplements for Longevity and healthier life There is currently no evidence in humans that taking supplements or hormones (such as human growth hormone) will make us live longer. However, it seems reasonably safe to take small amounts of certain supplements that have shown in preliminary research to be helpful.

Antioxidants People think that a longevity secret is to take as many antioxidants in high doses. But more is not necessarily better. If you plan to take them, use low doses, even it means taking a portion of a capsule. Acetyl l-carnitine and the antioxidant lipoic Acid are interesting nutrients that may be beneficial, more research is needed before making recommendations. Acetylcysteine could be of benefit. Carnosine appears to be able to extend the lifespan of cultured cells, and rejuvenate senescent cells. Resveratrol from red wine has potential. Eat a few grapes a week or drink a couple of ounces of wine a few times a week. Wine has many beneficial polyphenols. The compound that makes red wine a healthful drink may also hold one of the secrets to longevity. Researchers found that resveratrol acted on fruit flies and worms in the same way as a method known to extend longevity of animals including monkeys -- sharply restricting how much they eat.. The finding opens the possibility that people could take a pill to achieve the same benefits as strict dieting to live longer, healthier lives, said David Sinclair of Harvard Medical School in Boston, who led the study. "We found this chemical that can extend longevity of every organism we give it to." Royal Jelly has been studied in rodents. Vitamin D supplementation may improve longevity in those who have a low intake of vitamin D.

Nutritional supplements help mice stay healthy with age When mice were supplemented with more than 2 dozen vitamins, minerals nutrients and herbal extracts, they did not experience a 50 per cent loss in daily movement like other non-supplemented animals. The benefits were associated with an improvement in the activity of mitochondria as well as by reducing levels of free radicals. David Rollo, from McMaster University, says, This study obtained a truly remarkable extension of physical function in old mice, far greater than the respectable extension of longevity that we previous documented. This holds great promise for extending the quality of life of health span of humans. David Rollo says that it is unclear if the effects would be repeated in humans and years or decades of clinical trials would be required before any definitive conclusions could be made. The dietary product given to the mice included vitamins B1, B3 (niacin), B6, B12, C, D, E, folic acid, beta-carotene, CoQ10, rutin, bioflavonoids, ginko biloba, ginseng, green tea extract, ginger root extract, garlic, L-Glutathione, magnesium, selenium, potassium, manganese, chromium picolinate, acetyl L-carnitine, melatonin, alpha-lipoic acid, N-acetyl cysteine, acetylsalicylic acid, cod liver oil, and flax seed oil. Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Experimental Biology and Medicine 2010.

Longevity enhancers - Secrets and simple steps to take: The field of longevity and anti-aging is full of promises and unsubstantiated claims. As of now, there is no definitive research in humans of any substances or techniques that have been proven to extend longevity. However, there are a number of steps we can take to potentially live longer. These include:

1. Positive Attitude Have a positive attitude and improve your coping skills to daily stress. Embrace the philosophy that "It's not what happens to me, it's what I make of it." In a sample of people aged 50 and older who were followed for an average of 23 years, respondents who reported having a positive attitude toward aging lived an average of more than 7 years longer than those who had a more dismal view of getting older. Do you want to be happier? Take a look at my book on Happiness. A 50-year long study suggests that longevity is improved in men and women who are active, emotionally calm, and organized. Psychosomatic Medicine, July / August 2008. Optimists live longer, healthier lives than pessimists. Researchers at University of Pittsburgh, led Dr. Hilary Tindle, looked at rates of death and chronic health conditions among participants of the Women's Health Initiative study, which has followed more than 100,000 women ages 50 and over since 1994. Women who were optimistic were 14 percent less likely to die from any cause than pessimists and 30 percent less likely to die from heart disease after eight years of follow up in the study. Optimists also were also less likely to have high blood pressure, diabetes or smoke cigarettes. March 2009. Emotionally stable, intelligent men may live longer than neurotic, less intelligent men. Men with neurotic traits -- a tendency to worry and to experience emotional ups and downs -- and lower cognitive ability have a higher mortality rate than men without these traits. Psychosomatic Medicine, 2009. If you feel like you have most things in your life under control, this could make you feel even more confident and you'll probably live longer than other people. Feb. 3, 2014, Health Psychology, online.

People with a bright outlook on the future may live longer than those who take a dimmer view. Researchers in the Netherlands found that older men and women judged to have optimistic personalities were less likely to die over the nine-year study period than those with pessimistic dispositions. Much of this reduced risk was due to lower rates of death from cardiovascular disease among the most optimistic men and women in the study. They were 77 percent less likely to die of a heart attack, stroke or other cardiovascular cause than the most pessimistic group-regardless of factors such as age, weight, smoking and whether they had cardiovascular or other chronic diseases at the study's start. 2. Keep a normal weight Keep a healthy weight and reduce the number of calories consumed, but not to the point of starving. Caloric restriction prolongs life in animals, but less is known in humans. Cutting calories may do more than help people shed excess weight. According to a new report, a low-calorie diet may also slow age-related changes in the heart's genes that can lead to chronic disease. In the study, "middle-aged" 14-month-old mice were fed either a normal diet or one restricted in calories. When the mice reached 30 months of age, or the equivalent of 90 years of a human life span, the researchers analyzed their heart tissue. The hearts of mice on the low-calorie diets showed nearly 20% fewer age-related genetic changes and also appeared to have less DNA damage than those of mice on regular diets. Restricting calories also inhibited potentially disease-causing changes in the immune system, and suppressed apoptosis, or programmed cell death. A telephone poll conducted by ABC News found that 73% of respondents would not restrict their caloric intake in order to live longer. Mouse study: eating less at any age prolongs life. Bottom line: reduce caloric intake, but not to the point of having a miserable time. The size of an aging man's belly and the bulk of his biceps provide a more accurate picture of his mortality risk than body mass index (BMI) alone. As people age they typically lose muscle mass and gain belly fat.

3. What you eat determines how long you live Consume a healthy diet. Reduce consumption of foods cooked at high temperature. Drink more tea, particularly green tea. By relying more on steaming, boiling and stewing to cook foods and using acidic marinades on meat cooked with dry heat, people may be able to stay healthier. These strategies will reduce the amount of advanced glycation end products (AGEs), or glycotoxins that people consume with their food. The more AGEs healthy people eat, the greater their levels of inflammation and oxidative stress. Use the sugar substitute stevia which contains stevioside, a safe sweetener with no calories. Make sure to have more long chained fatty acids in your diet such as omega-3 fatty acids found in fish. Fresh fruit and vegetable consumption of greater than 5 servings a day is associated with progressively longer survival and lower mortality rates. 2013 American Society for Nutrition. Fruit and vegetable consumption and all-cause mortality: a dose-response analysis.

Duke Med Health News. 2013. Vegetarian diets aid longevity, reduce risk of all-cause mortality. But results are more significant in men than women. Further research is needed to determine why.

High total red meat consumption was associated with progressively shorter survival, largely because of the consumption of processed red meat. Consumption of nonprocessed red meat alone was not associated with shorter survival. Differences in survival associated with processed and with nonprocessed red meat consumption. Am J Clin Nutr 2014.

Herbs and spices Consume more culinary herbs and spices such as garlic, onion, curcumin, parsley, mint, and others.

4. Exercise and longevityRegular exercise and being physically active will help you live longer. Regular stretching or yoga is helpful in keeping joints and ligaments supple. If you are sedentary, even a small increase in activity can enhance your longevity by a couple of years. People who engage in plenty of light movement have a lower risk of developing a disability and losing their capacity to care for themselves. People who want to increase longevity may do so by running or engaging in regular activity. In one study done at Stanford University in California, middle-aged members of a runner's club were half as likely to die over a 20-year period as people who did not run. Running reduced the risk not only of heart disease, but of cancer and neurological diseases such as Alzheimer's. Any type of exercise will likely do the trick. Fitness, strength and flexibility do not inevitably fade away with age, and are more often a matter of lifestyle choicest. Often, the discomforts of middle-age, like lower back pain or stiff joints, are blamed on aging alone. However, a well-rounded exercise routine that includes aerobic activity, strength training and stretching can help people offset the effects of aging. Avoid extreme physical activities. Marathon runners have increased stiffness of the large arteries, suggesting that some types of regular high-intensity exercise may actually be bad for the heart, potentially leading to hardening of the arteries, high blood pressure, heart attack and even death. A moderate running regimen -- for instance two to three hours per week appears best for longevity. People who get either no exercise or high-mileage runners both tend to have shorter lifespans than moderate runners. The study was conducted by the Cardiovascular Research Institute at the Lehigh Valley Health Network in Allentown, PA and published in April 2014. Everyone knows that walking limbers the aging body, but did you know it keeps the mind supple as well? Walking can actually boost the connectivity within brain circuits, which tends to diminish as the grey hairs multiply. Frontiers in Aging Neuroscience, Published 2010. Excess TV viewing, such as more than 2 hours a day, shortens lifespan. Almost any amount and type of physical activity may slow aging deep in our cells, and middle age is a critical time to get the process rolling.

Even small changes can help confirmed couch potatoes improve their health and enhance longevity. Although the benefits of exercise and a healthy diet are well known, people may think they have to make major changes in their lifestyle to obtain any results. But any increase in physical activity is beneficial.

Basic lifestyle habits lead to a longer lifespan. Exercise, a healthy diet and good sleep slow down the aging process at a cellular level, and protect the body and mind against the harm caused by stress. July 29, 2014, Molecular Psychiatry

5. Avoid smoking cigarettes. Smokers die ten years younger on average than non-smokers As if smokers need another reason to kick the habit, California scientists have discovered that nornicotine, a byproduct of nicotine, the substance that makes cigarettes so addictive, causes a type of chemical reaction in the body similar to that which occurs when sugar is scorched or food goes bad. This reaction is thought to play a role in diabetes, cancer and other diseases. The interaction between sugars and proteins can produce substances called advanced glycation endproducts, or AGEs. The accumulation of AGEs appears to contribute to the aging process and certain diseases. Guided imagery may help quit smoking. 6. Loving connectoinsHave strong connections to others, whether through family and relatives, marriage, children, pets, or connecting with nature, planet earth, and the universe. Have loving and caring friends. Research suggests that having a strong network of friends helps people live longer.

7. Get a deep sleep. Getting a deep sleep is probably the most important longevity secret.

8. Keep your mind young and active by learning. Doing crossword puzzles or watching the show Jeopardy can do wonders in maintaining mental sharpness and word recall. The more educated you are, the less likely you are to become chronically ill or disabled, and your chances for greater longevity will improve. But, the amount of money you make plays a bigger role in whether your illness progresses.

9. Try to surround yourself with nature. Green trees in the neighborhood, sunshine in the home, are linked to longevity.

10. Tooth care Take care of your teeth and mouth to prevent or minimize gum disease and dental caries. Use a soft brush after a meal and then floss. Smoking can cause gum disease.

Addition longevity tips Work as long as you can. It is widely held that early retirement is associated with longer life expectancy and later retirement is associated with early death. Survival rates appear to improve with increasing age at retirement. This seems to be the case for both high- and low-income groups.

Participating in volunteer activities may add years to an older person's life. Volunteering may improve health by expanding retirees' social networks, increasing their access to resources and improving their sense of self-worth.

Drink more tea, and less sodas and sugared drinks. Limit fruit juice intake to no more than 8 ounces a day since fruit juices have a lot of fructose. Many delicious herbal teas are available, including green tea, ginger, rooibos herb, rose hips, mint, fennel herb, licorice, etc.

10. Limit coffee intake to one or two cups - chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections, which may increase the risk of cardiovascular or heart disease.

Drink an ounce or two of wine a few times a week.

Do DHEA hormone and pregnenolone hormone increase longevity? In high doses, DHEA and pregnenolone may increase the risk for cancer and heart arrhythmia. But it is possible, that in some people, low doses such as 1 or 2 mg may have health benefits.

Have fun, have more sexual intimacy and increase your pleasure with Passion Rx sexual pleasure pills. The herbs in this formula are Ashwagandha herb, Catuaba herb, Cnidium herb, Choline, DMAE brain enhancer, Muira Puama, Tribulus, Tongkat ali, and a version with Yohimbe herb.

Additional longevity enhancers: Being financially stable Having a satisfying career Healing old and new emotional wounds Having a personal religious or philosophical belief system that gives meaning to this world. Driving safely, wearing seat belts, minimizing the use of cell phones while driving.

Genetics One of the most important influences on longevity is genetics, something we cannot influence with our present scientific knowledge. People who have parents and grandparents who live long are more likely to also live a long life.

High blood pressure and longevity Hypertension can take years off both life expectancy and time lived free of disease. Research, based on data from a long-running U.S. heart-health study, found that the impact of high blood pressure on life expectancy may be more significant than previously estimated. Researchers found that high blood pressure at the age of 50 shaved about 5 years off men's and women's lives. It also caused them to endure 7 more years with cardiovascular disease compared with their peers who had normal blood pressure in middle-age. It's well known that high blood pressure raises the risk of heart disease, stroke and kidney failure, but only a few studies have looked at how blood pressure affects longevity.

Stress reduction Chronic psychological stress is associated with accelerated shortening of the caps, called telomeres, on the ends of chromosomes in white blood cells -- and thus hasten their demise -- according to a report in the Proceedings of the National Academy of Sciences. Telomeres promote chromosome stability. Telomeres shorten with each replication of the cell, and cells cease dividing when telomeres shorten sufficiently. The team investigated the theory that psychological stress affects telomere shortening and thereby contributes to a decrease in longevity. Their study included 39 healthy, premenopausal women who were primary caregivers for a child with a chronic illness, and 19 age-matched mothers of healthy children who served as a comparison "control" group. Stress was measured with a standardized questionnaire, and telomere length was measured in participants' blood samples. Within the caregiving group, the longer that a woman had been a caregiver, the shorter was the length of telomeres. In the 14 women with the highest stress scores, telomeres averaged 3,110 units in length; the 14 with the lowest stress had telomeres that averaged 3,660 units. In adults, telomeres shorten by an average of 31 to 63 units per year, so the scientists estimate that the 550-unit shortening in the high-stress group translates to 9 to 17 additional years of aging.

Mitochondria and acetyl-l-carnitine Decline in mitochondrial function may lead to cellular energy deficits, especially in times of greater energy demand, and compromise vital ATP-dependent cellular operations, including detoxification, repair systems, DNA replication, and osmotic balance. Mitochondrial decay may also lead to enhanced oxidant production and thus render the cell more prone to oxidative insult. In particular, the heart may be especially susceptible to mitochondrial dysfunction due to myocardial dependency on beta-oxidation of fatty acids for energy and the postmitotic nature of cardiac myocytes, which would allow for greater accumulation of mitochondrial mutations and deletions. Thus, maintenance of mitochondrial function may be important to maintain overall myocardial function. Herein, we review the major age-related changes that occur to mitochondria in the aging heart and the evidence that two such supplements, acetyl-l-carnitine (ALCAR) and (R)-alpha-lipoic acid, may improve myocardial bioenergetics and lower the increased oxidative stress associated with aging. We and others have shown that feeding old rats ALCAR reverses the age-related decline in carnitine levels and improves mitochondrial beta-oxidation in a number of tissues studied. However, ALCAR supplementation does not appear to reverse the age-related decline in cardiac antioxidant status and thus may not substantially alter indices of oxidative stress. Lipoic acid, a potent thiol antioxidant and mitochondrial metabolite, appears to increase low molecular weight antioxidant status and thereby decreases age-associated oxidative insult.

Japanese women had a life expectancy of 85.59 years in 2004, making them the world's longest living group for the 20th consecutive year. Japanese men trailed with a life expectancy of 78.64 years, which placed them second for longevity after Icelandic men, who live an average of 78.8 years.

Octogenerian has a baby An 88-year-old Indian farmer has become the father of a baby boy. He says he has sex daily and wants more kids. "I don't want to live to 100 but, as long as I live, I should be able to enjoy sex," said Virmaram Jat, who lives in a village in the Barmer district in the western desert sate of Rajasthan. The prosperous farmer, with a flowing white beard and a weather-beaten face, says he takes long walks every day and has been drinking fresh camel milk since childhood. The paper reported his latest wife -- his third -- is 45 years younger and delivered male twins last month, but only one boy survived. The octogenarian is a vegetarian and has never smoked cigarettes or drunk alcohol.

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Longevity, how to live longer with diet, food, and dietary ...

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Dental Pulp Stem Cells: A New Cellular Resource for …

August 4th, 2016 9:42 am

Corneal blindness afflicts millions of individuals worldwide and is currently treated by grafting with cadaveric tissues; however, there are worldwide donor tissue shortages, and many allogeneic grafts are eventually rejected. Autologous stem cells present a prospect for personalized regenerative medicine and an alternative to cadaveric tissue grafts. Dental pulp contains a population of adult stem cells and, similar to corneal stroma, develops embryonically from the cranial neural crest. We report that adult dental pulp cells (DPCs) isolated from third molars have the capability to differentiate into keratocytes, cells of the corneal stoma. After inducing differentiation in vitro, DPCs expressed molecules characteristic of keratocytes, keratocan, and keratan sulfate proteoglycans at both the gene and the protein levels. DPCs cultured on aligned nanofiber substrates generated tissue-engineered, corneal stromal-like constructs, recapitulating the tightly packed, aligned, parallel fibrillar collagen of native stromal tissue. After injection in vivo into mouse corneal stroma, human DPCs produced corneal stromal extracellular matrix containing human type I collagen and keratocan and did not affect corneal transparency or induce immunological rejection. These findings demonstrate a potential for the clinical application of DPCs in cellular or tissue engineering therapies for corneal stromal blindness.

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Dental Pulp Stem Cells: A New Cellular Resource for ...

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Epidemiology : Department of Preventive Medicine: Feinberg …

August 4th, 2016 9:42 am

The Epidemiology Division applies research methods to understand the patterns and causes of health and disease in the population and to translate this knowledge into programs designed to prevent disease. The division has a long history of involvement in NIH-sponsored multi-site, longitudinal cohort studies, and its faculty oversee many investigator-initiated, NIH-sponsored research projects and trials.

These studies focus on the natural history and etiology of various chronic diseases such as cardiovascular disease, cancer, obesity, diabetes, pulmonary disease, arthritis and chronic kidney disease. Researchers develop early, intensive prevention efforts for individuals and groups at high risk for developing certain chronic diseases, using refined statistical and epidemiological methods.

The division also educates and trains pre- and postdoctoral students, university faculty, and community members to use epidemiology, biostatistics, and bioinformatics to apply and translate research findings.

To study the distribution and determinants of complex diseases and conditions in diverse populations, and to identify and assess novel risk markers and prevention strategies for disease development and progression. The Epidemiology Division is dedicated to educating and training pre- and postdoctoral students, university faculty, and community members in the use of cutting-edge epidemiology, biostatistics, and bioinformatics methodologies for purposes of applying and translating research findings into improved public health.

Learn more about us via the links below.

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Epidemiology : Department of Preventive Medicine: Feinberg ...

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ARTICLE IN PRESS – Nanomedicine

August 4th, 2016 9:42 am

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Aging, genetics and longevity drugs – biopsychiatry.com

August 4th, 2016 9:42 am

BOSTON, Massachusetts (AP) -- A young man climbs from bed, stares into a mirror and glimpses his future.

He has just turned 34. His body is trim, his hair thick and dark. But what's that around his eyes? Those crow's-feet are getting harder to ignore. And do his teeth look a bit ground down by decades of chewing, or is it his imagination?

He will probably repeat the same check tomorrow, and tomorrow, and tomorrow -- about 16,000 more times if he, like the average American, dies at around 80. "I don't think 80 years is long enough. There's a lot of things I want to do," he laments.

But what can he -- or anyone -- do about getting old? He can't stop it, any more than he can dispel rain clouds roiling on the horizon, any more than ancient alchemists could distill a real elixir of immortality.

Or can he?

His name is David Sinclair. He is biologist at Harvard Medical School. His job is to prevent aging.

Catapulted by advances in biotechnology, scores of researchers have begun to pinpoint genes that may prolong human life while delaying its late-stage diseases, frailties and maybe even gray hair and wrinkles. Their remarkable successes in laboratory animals -- like worms that live four times longer than normal -- have already germinated several drug companies. They hope to develop compounds to stretch healthy lifetimes beyond limits once presumed to be fixed.

Some respected researchers envision millions living as long as Jeanne Calment of France, who died at age 122 in 1997. Tom Johnson, a University of Colorado geneticist, thinks people could one day live to 350 years old, spanning the ages like Methuselah and the other biblical patriarchs.

"I am absolutely convinced we are going to be able to extend human life," Johnson says. "This is not science fiction."

Under the best circumstances, a life-prolonging drug could conceivably arise in five years, says longevity guru Cynthia Kenyon, a molecular geneticist at the University of California-San Francisco.

While enthusiastic about distant prospects, some others predict only modest advances for the near future, because aging is such a fundamental and complex process. "I think it would be sensationalist and crazy to think we'd be seeing people living to 120, 130," argues Thomas Perls, a Boston University aging specialist who studies the genetics of centenarians.

In truth, no one knows for sure what can be accomplished or how soon. However, for the first time in human history, an intense and methodical quest is under way to turn off aging with proven science, instead of snake oil.

For centuries, aging has been understood as a scattered, chaotic, inevitable breakdown of the body and its organs. Like a car with too many miles, it eventually wears out. You can keep fixing parts, but others soon break down.

There was special reason for doubt in the genetic approach to slowing aging. Evolutionary theory dictates that we inherited genes that most helped our ancestors reach sexual maturity, not ones that helped or hurt them afterward.

If so, a genetic trigger for aging would be a long shot, except for one thing.

At first, it was more of a biological curiosity. In the 1930s, Cornell University nutritionist Clive McCay discovered that underfed rats live a lot longer than others. Just cut calories by about 30 percent, balance their diet, and they survive about 40 percent longer or more. The technique works in fish, fleas, and other species, and early data suggest it works in monkeys too, say researchers at the University of Wisconsin and the National Institute of Aging.

Underfeeding has revealed a second remarkable power: It keeps animals healthy, largely free of aging ailments like cancer and heart disease. They stay strong and energetic. They even keep more fur.

"On one side, the calorie-restricted mice are jumping, and running around, and looking young," says Stephen Spindler, a biochemist who does such experiments at the University of California-Riverside. "On the other side, the litter mates look old. They're gray, and they have more balding. They move less. It makes me want to go on a diet."

Even if it proved to work in people -- still an open question -- few would likely tolerate such a Spartan diet.

Maybe dieting isn't necessary, though. Researchers suspected that the effects of underfeeding point to some built-in biological switch after all: a set of master genes that can delay aging. Could they be found? And could their effect be mimicked by a drug that boosts or blocks the right proteins, the soldier molecules that do the work assigned by genes?

Kenyon, of the University of California-San Francisco, knew of a microscopic roundworm that, when starved or overcrowded, slips into suspended animation. In this hardened condition known as dauer, it can hold out for months. It would otherwise die within about three weeks.

This state is directed by a gene, daf-2, that controls growth by helping manufacture an insulin-like hormone. Kenyon wondered if worms with disabled variants of this gene might turn into spry, wiggly Methuselahs. In her tests, they did. Similar manipulations worked in flies and mice. A raft of such discoveries in the 1990s helped legitimize the new field of aging genetics.

"Aging had been cast kind of into the trash heap of biology, particularly in molecular terms. There's nothing much you can do about it, so what's the point?" says Kenyon, a 40-something dynamo who talks in a teenager's rapid-fire bursts and gives her age as 150.

Over the past 15 years, researchers have discovered several dozen genes that prolong life significantly in yeast, roundworms, fruit flies and mice. As in underfed animals, they appear to put off not just death, but the hobbling conditions of old age.

Most of these genes carry deadpan scientific monikers: p66shc, ctl-1, Lamin A. Others were mercifully christened in whimsy like age-1, clock, Methuselah, and INDY -- for "I'm Not Dead Yet," a name inspired by a line from a Monty Python movie.

Many longevity genes first tracked in animals have human counterparts. Other genes were first spotted in humans.

Nerve researcher Gabrielle Boulianne, of the University of Toronto, was studying one of them in 1998. She was researching amyotrophic lateral sclerosis, the degenerative nerve condition known as Lou Gehrig's disease. It had been linked to a gene known as SOD1, which treats metabolic waste products. Since fruit flies carry a twin gene, she transplanted and supercharged the human gene in their nerve cells, hoping to develop a research model for the disease.

What happened next was unforeseen: The flies lived an average of up to 40 percent longer. "In some respects, I was shocked," Boulianne says. "That was not the original goal."

In keeping with underfeeding experiments, some of these genes help resist environmental threats, like food shortages, overheating or infection. Some slow down metabolism or boost its efficiency. Others help recondition the body's protein building blocks or reduce the destruction of gene-degrading free radicals. Still others make hormones that control growth and cell division, a process that goes awry in cancer.

Many of these genes, like gatekeepers, open or close access to other genes. At the Massachusetts Institute of Technology, Lenny Guarente -- Sinclair's mentor -- is pursuing a gatekeeper gene common to mice and humans, SIRT1. It is tied to several players implicated in aging: sugar metabolism, hormone signaling, and cellular death.

In theory, such genes can block the chemical messengers that spur aging ailments like cancer, heart disease and Alzheimer's. These researchers dream of one pill that fits all.

"It's a new way in thinking about diseases," says Guarente, a lanky 51-year-old with an impish smile who looks like he may have already found an aging secret and tried it.

Elixir Pharmaceuticals, which he co-founded in Cambridge, Massachusetts, plans to test several drugs in animals. Since its early days in 2001, it has raised $36.5 million and grown to a staff of about 30, according to CEO Edward Cannon.

He acknowledges it's still unclear how to move a longevity drug to market. Given even the paltry human life span now, the thorough testing required by the U.S. Food and Drug Administration would take too long. Cannon says the first longevity drugs might be approved for specific diseases of aging, but prescribed more broadly by some doctors to prolong life.

"It's a great business opportunity," says Xi Zhao-Wilson, CEO of a competitor, Biomarker Pharmaceuticals in Campbell, California. "The market is huge, we know that."

Some executives say their longevity products might be marketed first for pets or as human dietary supplements, allowing makers to skirt full-blown human testing. It's a market where claims are sometimes made on shaky grounds, but the longevity companies say their products would be based on solid science.

Some biologists worry that likely side effects are being undersold already. They say that nearly any drug that alters the workings of a powerful master gene will probably stir up unintended effects. They warn of infertility, sluggish metabolism or weakened immunity.

Longevity researcher Steven Austad at the University of Idaho says all aging genes found so far would do harm "not necessarily apparent in the laboratory."

Yet he felt confident enough to bet a colleague $150, on a lark, that someone born by 2000 will be alive and well in the year 2150. Assuming that person wouldn't be either of them, the two scientists banked their combined $300 to pay the winner's descendants when the bet is decided.

By then, the pot is estimated at $500 million, thanks to something that only gets better with time: compound interest.

Taking Austad's bet was sociologist S. Jay Olshansky, an authority on aging demographics at the University of Illinois-Chicago. "You get many of these gene jockeys grossly exaggerating and extending the work done on invertebrates and other organisms to ... humans," he says. But even he holds great hope for the field in the long run.

Some scientists and scholars say it's already time to start considering how to handle the profound impact long-life drugs would have on society. Will they tack on extra years of sickness to the bonus years of health, overwhelming the medical system? Can society create enough jobs for older workers and support retirees longer?

Political scientist Francis Fukuyama, on The President's Council on Bioethics, says such problems beg for discussion because a proven longevity drug would be "almost impossible to stop."

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Aging, genetics and longevity drugs - biopsychiatry.com

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Sermorelin Therapy | Human Growth Hormone, HGH | HGH Doctors

August 4th, 2016 9:42 am

Sermorelinis agrowth hormonereleasing hormone (GHRH); it stimulates the increased production of Human Growth Hormone (HGH) in the body. Sermorelin works by naturally stimulating the body to produce more of its own natural Human Growth Hormone. It will not produce excessive levels of HGH; the body will only use the amount of Sermorelin it needs to manufacture a healthy amount so it is safe and effective.

Sermorelin is considered just as effective as HGH injections unless a medical condition prevents the body from producing Human Growth Hormone. This is why your EHormonesMD HGH Doctor will do a complete screening to find your individual needs and determine if Sermorelin or HGH is right for you. As with most medial conditions, it is always important to work with a specialist.

Sermorelin stimulates the production of Human Growth Hormone, or HGH as it is more commonly known. Production of HGH typically remains sufficient until our early 20s, subsequently declining with age. HGH is responsible for stimulating growth in cells, tissues and organs. The positive effects of endogenous HGH can be seen in healthy lean mass (your muscle tissue), bone density, decreased central body fat, regulated blood sugar levels and improved immune function. HGH and Testosterone are the cornerstones of Age Management Medicine (anti-aging).

If you are 30 years of age or over, experiencing decreased energy levels, depleted muscle tone and increased central body fat, you may be a candidate for Sermorelin Therapy. First, an EHormonesMD managed physician will have to perform comprehensive lab work and a physical examination. To get started, simply fill out the form to the right or call us directly at1-800-658-8858.

More on Human Growth Hormone HGH More on Testosterone

Click here to read the paper by the Society for Applied Research in Aging (SARA)

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Sermorelin Therapy | Human Growth Hormone, HGH | HGH Doctors

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Endocrinology – Greensboro Medical

August 4th, 2016 9:42 am

Endocrinology

Dr. Kohut is originally from Sewickley, Pennsylvania. Greensboro has been his home since 1982. He earned his Bachelor of Science degree in Zoology from the University of Cincinnati and his Doctor of Medicine from the University of Cincinnati, School of Medicine. His training in Internal Medicine was completed in 1980 and his fellowship in Endocrinology and Metabolism was completed in 1982, both at Mayo Graduate School of Medicine in Rochester, Minnesota.

Dr. Kohut is board certified in Endocrinology and Metabolism and is board certified by the American Board of Internal Medicine. He is also board certified in Clinical Lipidology. He is licensed in medicine in the state of North Carolina. He is an active staff member at Moses Cone Hospital and is a member of the American College of Physicians.

Dr. Kohuts interests outside of work include woodworking and water skiing.

Endocrinology

Dr. Balan is originally from Bangalore, India. Greensboro has been her home since 2003. She earned her Doctor of Medicine from Bangalore Medical College in India. Dr. Balan completed her internship at Yale. Her training in Internal Medicine was completed at Columbia University and her fellowship in Endocrinology and Metabolism was completed at Brown University in Providence, Rhode Island.

Dr. Balan is board certified in Endocrinology and Metabolism and is board certified by the American Board of Internal Medicine. She is licensed in medicine in the state of North Carolina. She is an active staff member at Moses Cone Hospital and is a member of the American Association of Clinical Endocrinology and the Endocrinology Society

Dr. Balans interests outside of work include reading and spending time with her family.

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Endocrinology - Greensboro Medical

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Welcome to Greensboro Endocrinology – Dr. Michael Altheimer

August 4th, 2016 9:42 am

Welcome to Greensboro Endocrinology, the endocrinology, diabetes, and internal medicine practice of Michael D. Altheimer, MD. Board certified in internal medicine and endocrinology, Dr. Altheimer has built a reputation for providing high quality and exceptionally personalized care since establishing his practice in Greensboro, NC, in 1986.

At Greensboro Endocrinology, we take the time to listen to your concerns. We provide state-of-the-art, evidence-based care, delivered in an individualized and compassionate manner. Most of our patients seek long-term care for diabetes, lipid disorders, thyroid conditions, and/or other endocrine and metabolic problems. Most often, this is done in the form of consultative careworking closely with your primary care physician or other referring provider. In addition, for a smaller segment of our patient population, we provide comprehensive long-term adult primary medical care with a focus on wellness and prevention. We encourage all of our patients to be well-informed and active participants in their own healthcare. Thank you for placing your trust in our practice as we partner in your care.

In order to assure the highest level of personalized service and patient satisfaction, each member of our team is carefully chosenbased on training, experience, competence, and (most importantly) a genuine caring attitude.

Greensboro Endocrinology will soon offer our patients secure, 24/7 online access to important information in their electronic medical records, as well as secure communications, through our patient portal.

Conveniently located off North Elm Street (at the first traffic light north of Cone Blvd), at 7C Corporate Center Court, Greensboro Endocrinology shares space, staff, lab, and support services with Medoff Medical, which is the established gastroenterology practice of Jeffrey Medoff, MD.

We hope you find the information on this website helpful. Pleasecontact us with any questions, concerns, or suggestions.

Dr. Altheimer has been my endocrinologist for several years. Upon my first visit I found him knowledgeable and well informed, and he instilled in me a confidence that he could resolve my medical issues. I have been extremely pleased with my treatment and would not hesitate to continue having him as my physician.

-Cindy

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Directions – Greensboro Endocrinology, Dr. Michael Altheimer

August 4th, 2016 9:42 am

We are conveniently located off N. Elm Street (at the first traffic light north of Cone Blvd), at 7C Corporate Center Court, in Greensboro, NC.

If you're headed north on N. Elm Street, turn right at traffic light at BB&T Bank (3150 N. Elm Street), onto Corporate Center Court. Greensboro Endocrinology is located behind the BB&T Bank building, at the far end of the parking lot.

Surface parking and patient drop-off are conveniently located directly in front of our entrance.

Click here for door-to-door directions

Take I-40 West Take highway 70 exit Follow highway 70 into Greensboro Turn right onto Magnolia Street Turn left onto Northwood Street Turn right onto Elm Street Turn right at the first traffic light after crossing Cone Boulevard, onto Corporate Center Court. Office is up and behind the BB&T Bank, at the far end of the parking lot

Take US 220 N to Greensboro Merge onto Freeman Mill Road Freeman Mill Road will become Edgeworth Street Turn right onto West Smith Street Turn left onto Elm Street Turn right at the first traffic light after crossing Cone Boulevard, onto Corporate Center Court. Office is up and behind the BB&T Bank, at the far end of the parking lot Travel time approximately 40 minutes

Take I-40 East into Greensboro Take exit 210 High Point/PTI Airport Turn left at bottom of ramp onto Hwy 68 N Exit right onto Bryan Blvd Take the Westridge Road exit Turn right onto Westridge Road Turn right onto Battleground Ave/US-220 Turn left onto Pisgah Church Road Turn right onto North Elm Street Turn left at the first traffic light onto Corporate Center Court. Office is up and behind the BB&T Bank, at the far end of the parking lot. Travel time approximately 45 minutes

Take I-85 N to Greensboro Take exit 120 (85 Business) Take the exit for US-29 North Take the Cone Blvd exit Merge onto East Cone Blvd Turn right onto North Elm Street Turn right at the first traffic light after crossing Cone Boulevard, onto Corporate Center Court. Office is up and behind the BB&T Bank, at the far end of the parking lot Travel time approximately 35 minutes

Take US-29 S into Greensboro Take the Cone Blvd exit erge onto East Cone Blvd Turn right onto North Elm Street Turn right at the first traffic light after crossing Cone Boulevard, onto Corporate Center Court. Office is up and behind the BB&T Bank, at the far end of the parking lot. Travel time approximately 35 minutes.

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Directions - Greensboro Endocrinology, Dr. Michael Altheimer

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Albany Med Community Division: The Endocrine Group

August 4th, 2016 9:42 am

TheAlbany MedCommunity Division: The Endocrine Group offers the highest level of medical care in a welcoming environment, close to home. We see patients with a wide spectrum of endocrine disorders, including pituitary and adrenal problems, disorders of calcium metabolism, and a variety of other endocrine abnormalities.

The Endocrine Group enhances the convenience of our health services by offering an endocrine surgeon and a podiatry clinic on-site. Dr.Carrie Carsellohas extensive experience in endocrine surgery and the experts at the on-site podiatry clinic specialize in foot care for patients with diabetes.

We also have a team of Certified Diabetes Educators, Registered Dietitians, Nurse Practitioners and Physician Assistants who are specially trained in the field of endocrinology to work with our board-certified endocrinologists.

Medical Nutrition Therapy is offered by our Registered Dietitian Nutritionist (RDN) for theprevention and treatment of diabetes, cardiovascular problems, and high blood pressure. Medical Nutrition Therapy is also offered for patientsto helpmanagecancer, digestive problems, eating disorders, pregnancy, child, adolescent, and adult weight concerns. Sports performance advice and healthy eating tips are also addressed.

In the medical field, it is extremely important to be up-to-speed in the latest technologies that improve the overall patient experience. For this very reason, we have a Certified Clinical Densitometrists who operate our up-to-date DXA machine for precise measurement of bone density in treating our patients with osteoporosis. Additionally, patients with thyroid disorders such as nodules and/or cancer can benefit from high resolution ultrasound operated by ultrasound technicians highly experienced in thyroid sonography.

Our office location and contact information is:

Albany Med Community Division: The Endocrine Group 1365 Washington Ave., Suite 300 Albany, NY 12206

Phone: (518) 489-4704 Fax: (518) 489-0512

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Towson Sports Medicine Maryland | Sports Medicine Baltimore MD

August 4th, 2016 9:42 am

Towson Sports Medicine Center, the first sports center of its kind in Baltimore, was established in 1984 by Baltimore Colts Team Physician and orthopaedic surgeon at Towson Orthopaedic Associates, by Dr. Kenneth Gertsen. It features state-of-the-art rehabilitation for all orthopaedic injuries and orthopaedic-related problems. A division of Towson Orthopaedic Associates, TSM specialties also include injury treatment programs for athletes at any age, any competitive level, from the adolescent to senior, recreational to Olympic athlete.

Towson Sports Medicine NEWS

At PerformFit Sports Experience, we believe that everyone should have the chance to reach their performance goals through the best training methods available. PerformFit Sports Experience is the premiere sports performance training facility in Cockeysville. We strive to help you become the best you can be in all aspects of life!

Whether you are an athlete looking to take your performance to the next level or a parent

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NY Times By Gretchen Reynolds, August 26, 2015 Are we, with the best of intentions, putting young athletes at risk when we urge them to drink lots of fluids during steamy sports practices and games?

A new report about overhydration in sports suggests that under certain circumstances the answer is yes, and that the consequences for young athletes can be

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May, 2015,Towson, MarylandAwareness about the dangers of concussion is at an all-time high, in part because of the highly publicized concussion lawsuit brought by professional football players against

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Towson Sports Medicine VIDEOS

What We Offer at Towson Sports Medicine

Towson Sports Medicine is recognized as being the best and the largest orthopaedic rehabilitation facilities in the Baltimore area. Our staff of physicians, physical therapists and certified athletic trainers has been serving patients for more than 75 years.Towson Sports Medicine Center offers a comprehensive rehabilitation program for injured and post-surgical patients as well as the competitive, weekend and occasional athlete of any age.We are dedicated to providing superior care to those individuals whose lives are entrusted to us.

Towson Sports Medicine CenterTowson Orthopaedic Associates Ruxton Professional Center 8322 Bellona Avenue Towson, MD 21204 410-337-8847

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Towson Sports Medicine Maryland | Sports Medicine Baltimore MD

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Maryland Sports Medicine Center – Orthopedic Care in Olney …

August 4th, 2016 9:42 am

MAKE AN APPOINTMENT

Maryland Sports Medicine Center has, in addition to sports medicine and physical therapy, an orthopedic surgeon.

Please call 301.232.1050 to schedule an appointment today!

Let Maryland Sports Medicine Center assist in your pre- and post-operative rehabilitation. Dr. Higgins has privileges and performs surgery at Montgomery General Hospital in Olney, MD and the Chevy Chase Surgery Center in Chevy Chase, MD.

Check out our outpatient services.

Are you suffering from acute or chronic back pain, shoulder injuries, or a sports-related injury? We also treat:

We offer evening and early morning appointments to accommodate the busy work schedules and lifestyles of our patients.

Please call 301.232.1050 to schedule an appointment at our practice in Olney, Maryland today!

David L. Higgins, MD at Maryland Sports Medicine Center's state-of-the-art facility in Olney, Montgomery County, provides the best orthopedic care and physical therapy for patients with all types of sports and work-related injuries of the muscle, tendon, ligament and bone. In addition, we specialize in post-operative rehabilitation of the shoulder and knee. Doctor Higgins is a certified orthopedic surgeon.

Dr. Higgins received his medical degree from Georgetown University School of Medicine and has been in practice in Maryland since 1991. Dr. Higgins is board certified in orthopedic surgery, performed a fellowship in sports medicine at Hughston Orthopedic Clinic in Columbus, Georgia, and completed his residency at Baylor College of Medicine in Houston, Texas.

Recognized by the U.S. Olympic Committee as a National Network Member, our fully equipped physical therapy centerin Olney, Maryland is staffed with knowledgeable and supportive physical therapists who guide and assess patient rehabilitation to keep patients injury-free and active.

Using "hands-on" physical therapy techniques including: soft tissue and joint mobilizations, therapeutic exercises, custom splinting and modalities such as ultrasound, electrical stimulation and iontophoresis, we are able to greatly reduce patient discomfort and recovery time.

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Society for Endocrinology journals

August 4th, 2016 9:42 am

Journal of Endocrinology

provides a wide coverage of research in all aspects of endocrinology. It is in the top ranks of global endocrine journals and publishes high quality, leading-edge research from all over the world. The readership of the journal is worldwide, with 40% of readers in North America.

provides a forum for papers devoted to describing the mechanisms underlying the action of hormones and related substances, their regulation in physiological processes and disruption in pathological conditions.

is the established global forum for basic, clinical and experimental investigations which concern hormones and cancer in human and animal subjects. Endocrine-Related Cancer publishes all aspects of basic, translational and clinical research in hormone-dependent cancers, and in cancers of endocrine organs.

is the official clinical journal of the Society for Endocrinology. It is essential reading both for those engaged in endocrinological research and for those involved primarily in clinical practice. Clinical Endocrinology is published by Wiley-Blackwell and hosted by Wiley Online Library: different terms and conditions apply.

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ABFM | Sports Medicine

August 4th, 2016 9:42 am

The American Board of Family Medicine offers a Certificate of Added Qualifications (CAQ) in Sports Medicine. This CAQ is designed to recognize excellence among those Diplomates whose practices emphasize expertise in the Sports Medicine field. The CAQ in Sports Medicine is offered twice annually in conjunction with the American Board of Emergency Medicine, the American Board of Internal Medicine, the American Board of Pediatrics and the American Board of Physical Medicine and Rehabilitation.

Certification Requirements

Recertification Requirements

Recertification in Sports Medicine is offered in the ninth or tenth year of the certificate. Candidates may choose to seek recertification in July of either year and in case of failure they will be given the opportunity to retake it in November.

Note: Successfully recertifying earlier than your 10th year of certification starts a new certification cycle and the remaining time on your original certification is foregone.

Requirements to sit for the Sports Medicine Recertification Examination include:

Sports Medicine Examination Content This blueprint describes the content of the Sports Medicine Examination. The blueprint shows how much each category contributes to the overall examination. The subcategories describe possible content, but an individual item at the lower levels will not necessarily appear on a given examination.

Click Here to review the Sports Medicine Examination Content [35 KB]

Sports Medicine

Sports Medicine Summer [390 KB]

Fellowship Performance [542 KB]

Rescore

View important dates and deadlines for Sports Medicine.

Get the answers to frequently asked questions.

Find out how to apply for an exam.

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