StemCell Therapy

Is there an arthritis diet?

For most forms of arthritis, diets play little or no role in precipitating or exacerbating the condition. However, in general, oils of fish have been shown to have anti-inflammatory properties. Some arthritis suffers benefit from omega-3 fatty acid supplements. Some feel they benefit from the curcumin that is present in curry foods.

Gout is a particular type of arthritis that is clearly diet-related. Foods that are high in purines, especially red meats and shellfish, can worsen the condition. Moreover, certain foods elevate the levels of uric acid, including alcohol (especially beer) and those foods containing high amounts of fructose (such as the corn syrup found in soft drinks). For people with celiac disease, gluten-containing foods (wheat, barley, rye) can worsen joint pains.

With the exception of the unique metabolic form of arthritis in gout and celiac disease, there are no universally accepted foods that must be avoided by people with arthritis. Gout can be promoted and precipitated by dehydration as well as fructose-containing foods (corn syrup, etc.), high-purine foods (seafood, shellfish, organ meats), and alcoholic beverages (particularly beer). People with gout should avoid these foods. The arthritis of celiac disease can be worsened by intake of gluten-containing foods (wheat, barley, rye).

Medically Reviewed by a Doctor on 5/17/2016

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Arthritis Symptoms, Treatment, Causes - Is there an arthritis ...

Often called "wear and tear" arthritis, osteoarthritis (OA) is the most common form of arthritis in the U.S. In most cases, over time, cartilage in joints breaks down, and OA symptoms begin to occur. OA is most commonly found in the:

Wrists, elbows, shoulders, and ankles can also be affected by OA, but this occurs less frequently. When OA is found in these joints, there may have been a history of injury or stress to that joint.

Typically, OA comes on slowly. For many, the first signs are joints that ache after physical work or exercise. As the disease progresses, other most common symptoms include:

If you are experiencing any of these symptoms, it's important to talk to your doctor to find out if you have OA.

OA most often occurs in the following areas:

Knees Because knees are primarily weight-bearing joints, they are very commonly affected by OA. If you have OA in your knees, you may feel that these joints are stiff, swollen, and painful, making it hard to walk, climb, and get in and out of chairs and bathtubs.

Hips OA in the hip can cause pain, stiffness, and severe disability. Hips both support the weight of the body and enable movement of your lower body. When you have OA in your hips, you may also feel the pain in your groin, inner thigh, or knees. OA in the hip can lead to difficulty moving, bending, and walking.

Fingers and Hands When OA occurs in hands and fingers, the base of the thumb joint is commonly affected and people experience stiffness, numbness, and aching. Other symptoms of hand and finger OA include:

Spine If you have OA of the spine, you may experience stiffness and pain in the neck or in the lower back. Sometimes arthritis-related changes in the spine can put pressure on the nerves, causing weakness or numbness in your arms or legs.

While the exact cause of OA is unknown, joint damage can be due to repetitive movement (also known as "wear and tear"). It can also begin as the result of an injury. Either way, with OA there's erosion of the cartilage, the part of the joint that covers the ends of the bones.

Here are some factors that may increase your risk of developing OA:

Age Age is the strongest risk factor for OA. Although OA can start in young adulthood, in these cases, it is often due to joint injury.

Gender OA affects both men and women. However, before age 45, OA occurs more frequently in men; after age 45, OA is more common in women.

Joint injury or overuse caused by physical labor or sports Traumatic injury to a joint increases your risk of developing OA in that joint. Joints that are used repeatedly in certain jobs may be more likely to develop OA because of injury or overuse.

Obesity The chances of getting OA generally increase with the amount of weight the bodys joints have to bear. The knee is particularly affected because it is a major weight-bearing joint.

Joint Alignment People with joints that dont move or fit together correctly, like bowlegs, dislocated hips, or double-jointedness, are more likely to develop OA in those joints.

Heredity An inherited defect in one of the genes responsible for manufacturing cartilage may be a contributing factor in developing OA.

If you experience joint pain, stiffness, and/or swelling that won't go away, you should make an appointment to see your doctor. Your doctor will be able to determine if you have arthritis and, if so, what type.

When you see your doctor about your symptoms, he or she may ask questions about when and how you started experiencing them. The doctor will probably give you a physical examination to check your general health, and examine the joints that are bothering you.

You may also need other tests to help confirm the diagnosis of OA and determine the extent and severity of joint damage. Some of these may include:

If you are experiencing some of these symptoms, the sooner you talk to your doctor, the sooner you may get diagnosed and get treatment.

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Osteoarthritis Symptoms and Causes | Information about ...

Rheumatoid arthritis (RA) is an autoimmune disease where the body's immune system attacks normal joint tissues, causing inflammation of the joint lining.

This inflammation of the joint lining (called the synovium) can cause pain, stiffness, swelling, warmth, and redness. The affected joint may also lose its shape, resulting in loss of normal movement. RA is an ongoing disease, with active periods of pain and inflammation, known as flares, alternating with periods of remission, when pain and inflammation disappear.

RA can affect many different joints. In some people, it can even affect parts of the body other than the joints, including the eyes, blood, the lungs, and the heart.

Although RA is often a chronic disease, the severity and duration of symptoms may unpredictably come and go. With RA, people experience periods of increased disease activity, called flare-ups or flares, alternating with periods when the symptoms fade or disappear, called remission.

If you experience some of these symptoms, you may want to talk to your doctor:

As RA progresses, about 25% of people with the disease develop small lumps of tissue under the skin, called rheumatoid nodules, which can vary in size. Usually, they are not painful.

If you are experiencing any of the symptoms described above, it is important to find out from a doctor if you have RA.

The exact causes of RA are unknown. But research has shown that several factors may contribute to the development of RA:

Rheumatoid arthritis can cause joint inflammation, which can affect the ability to go about your daily activities. If left untreated, RA can worsen and destroy joints. After the onset of the disease, some of the effects of RA are as follows:

If you have persistent discomfort and swelling in multiple joints on both sides of your body, make an appointment to see your doctor. Early diagnosis and treatment can help slow disease progression.

When you see your doctor about your symptoms, he or she may ask questions about your medical history and examine the joints that are bothering you. Your doctor will also decide if you need other tests to help confirm the diagnosis of RA and determine the extent and severity of joint damage. These may include:

Blood Tests

X-rays

If you have joint pain, stiffness, and/or swelling that won't go away, you may have arthritis. Talk with your doctor about your symptoms.

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What is Rheumatoid Arthritis?

What is the treatment for arthritis?

The treatment of arthritis is very dependent on the precise type of arthritis present. An accurate diagnosis increases the chances for successful treatment. Treatments available include physical therapy, home remedies, splinting, cold-pack application, paraffin wax dips, anti-inflammatory medications, pain medications (ranging from acetaminophen [Tylenol] to narcotics), immune-altering medications, biologic medications, and surgical operations. For treatments of particular forms of arthritis, see the corresponding articles for the form of arthritis of interest.

The outlook for patients with arthritis depends on its severity, complications, and whether or not there are non-joint manifestations of the disease. For example, rheumatoid arthritis can affect the lungs, kidneys, eyes, etc. Chronic joint inflammation can lead to permanent damage to the joint and loss of joint function, making movement difficult or impossible.

Since most forms of arthritis are inherited to some degree, there is no real way to prevent them. Arthritis that follows joint injury could be prevented by adhering to safety regulations and trying to avoid becoming injured. Arthritis related to infection (for examples, septic arthritis, reactive arthritis, Whipple's disease) could be prevented by not becoming infected with the causative organism. The extent to which this is possible varies depending upon the individual condition.

Medically Reviewed by a Doctor on 5/17/2016

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Arthritis Symptoms, Treatment, Causes - MedicineNet

Arthritis Pain

Arthritis is a painful and degenerative condition marked by inflammation in the joints that causes stiffness and pain. Osteoarthritis, the most common type of arthritis, gets worse with age and is caused by wear and tear over the years.

Doctors traditionally treat arthritis with anti-inflammatory medications and painkillers. However, some medications cause side effects, and a natural approach to pain relief is becoming more popular. Remember to consult your doctor before trying these natural remedies.

Your weight can make a big impact on the amount of pain you experience from arthritis. Extra weight puts more pressure on your jointsespecially your knees, hips, and feet.

Reducing the stress on your joints by losing weight will improve your mobility, decrease pain, and prevent future damage to your joints.

There are more benefits to exercise than just weight loss. Regular movement helps to maintain flexibility in your joints. Weight-bearing exercises like running and walking can be damaging. Instead, try low-impact exercises like water aerobics or swimming to flex your joints without adding further stress.

Simple hot and cold treatments can make a world of difference when it comes to arthritis pain. Long, warm showers or bathsespecially in the morninghelp ease stiffness in your joints. Use an electric blanket or heating pad at night to keep your joints loose and use moist heating pads.

Cold treatments are best for relieving joint pain. Wrap a gel ice pack or a bag of frozen vegetables in a towel and apply it to painful joints for quick relief.

Injections for knee pain. Compare your options

Acupuncture is an ancient Chinese medical treatment that involves inserting thin needles into specific points on your body. This is supposed to re-route energies and restore balance in your body.

It is thought that acupuncture has the ability to reduce arthritis pain. If you want to try this treatment method, be sure to find an experienced acupuncturist with good references.

Meditation and relaxation techniques may be able to help you reduce pain from arthritis by reducing stress and enabling you to cope with it better. According to the National Institutes of Health (NIH), studies have found that the practice of mindfulness meditation is helpful for some people with painful joints. Researchers also found that those with depression and arthritis benefitted the most from meditation.

Everyone needs omega-3 fatty acids in their diets for optimum health. However, these fats may also help your arthritis. Fish oil supplements, which are high in omega-3s, may help reduce joint stiffness and pain.

Another fatty acid that can help is gamma-linolenic acid, or GLA. Its found in the seeds of certain plants like evening primrose, borage, hemp, and black currants. You can also buy the oils of the seeds as a supplement. However, be sure to check with your doctor before taking them.

Turmeric, the yellow spice common in Indian dishes, contains a chemical called curcumin that may be able to reduce arthritis pain. The secret is its anti-inflammatory properties.

The NIH reports that turmeric given to lab rats reduced inflammation in their joints. Research on humans is scarce, but it cant hurt to add this tasty spice to your dinners.

According to the Arthritis Foundation, regular massaging of arthritic joints can help reduce pain and stiffness, and improve your range of motion. Work with a physical therapist to learn self-massage, or schedule appointments with a massage therapist regularly.

Hear from real patients who treated their knee pain with injectables

Your massage therapist should be experienced with working on people who have arthritis. Check with your doctor for a recommendation.

There are many kinds of herbal supplements on the market that claim to be able to reduce joint pain. Some of the herbs touted for arthritis pain include boswellia, bromelain, devils claw, ginkgo, stinging nettle, and thunder god vine.

Always talk to your doctor before trying a new supplement to avoid side effects and dangerous drug interactions.

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If you're facing a medical emergency, call your local emergency services immediately, or visit the nearest emergency room or urgent care center.

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In an effort to determine if stem cell therapy can prevent or improve a condition called "diabetic foot" caused by poor blood flow in patients with diabetes, a team of researchers in China has found that transplanting human placenta-derived mesenchymal stem cells (MSCs) into rats modeled with diabetes can affect blood vessel growth, potentially improving blood flow and preventing critical limb ischemia (CLI), a condition that results in diabetic foot and frequently leads to amputation.

The study will be published in a future issue of Cell Transplantation and is currently freely available on-line as an unedited, early epub at: http://www.ingentaconnect.com/content/cog/ct/pre-prints/content-ct-1594_liang_et_al

"CLI describes an advanced stage of peripheral artery disease characterized by obstruction of the arteries and a markedly reduced blood flow to the extremities. CLI is associated with high rates of mortality and morbidity, putting the patients at high-risk for major amputation," said study co-author Dr. Zhong Chao Han of the Beijing Institute of Stem Cells, Health and Biotech. "Mesenchymal stem cells are ideal candidates for transplantation because they have both angiogenic (potential to form new blood vessels) and immunomodulatory properties and are capable of differentiating into three different lineages. The utility of placenta-derived MSCs is poorly understood, so we sought to investigate the efficacy of combined regular therapy and cell therapy in treating diabetes-related CLI."

According to the researchers, human placenta was obtained from full-term cesarean section deliveries with written informed consent of the mother. The use of human-derived cells was approved by the Institutional Biomedical Research Ethics Committee of the Chinese Academy of Medical Science and Peking Union Medical College.

After injection into rats surgically modeled with CLI, the stem cells were traced and counted at various points in time. The researchers found that the stem cell counts decreased dramatically over time, but a few cells differentiated into vascular cells. The infused cells also secreted cytokines, which are small proteins secreted by cells that have a specific effect on the interactions and communications between cells.

"We believe that cytokines secreted by MSCs attract endothelial cells, a type of cells that make up the tissues lining the interior surface of blood vessels," said the researchers. "These cells participate in building new vascular tissues and also inhibit inflammation."

The researchers concluded that their experimental data implied that MSCs improved ischemia recovery in diabetic rats via direct cell differentiation and paracrine (protein-mediated) mechanisms, although the two mechanisms exist simultaneously. The paracrine mechanisms, said the researchers, were likely more important than direct cell differentiation.

"So far, MSC therapy represents a simple, safe and effective therapeutic approach for diabetes and its complications," the researchers concluded. "Our studies lay the groundwork for the transition from the experimental bench to the clinical bedside."

"Diabetes is becoming more prevalent across the globe and stem cell therapy may be a vital approach to serious vascular complications," said Dr. Maria Carolina Oliveira Rodrigues of the Ribeiro Preto Medical School - University of So Paulo, Brazil and section editor of Cell Transplantation. "Future studies should aim to expound upon previous findings in MSC transplantation studies and confirm the efficacy of placenta-derived MSCs for CLI."

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Transplantation with Human Placental Stem Cells Improves ...

Ageing, also spelled aging, is the process of becoming older. In the narrow sense, the term refers to biological ageing, especially of human beings and many animals (whereas for example bacteria, perennial plants and some simple animals are potentially immortal). In the broader sense, ageing can refer to single cells within an organism which have ceased dividing (cellular senescence) or to the population of a species (population ageing).

In humans, ageing represents the accumulation of changes in a human being over time,[1] encompassing physical, psychological, and social change. Reaction time, for example, may slow with age, while knowledge of world events and wisdom may expand. Ageing is among the greatest known risk factors for most human diseases:[2] of the roughly 150,000 people who die each day across the globe, about two thirds die from age-related causes.

The causes of ageing are unknown; current theories are assigned to the damage concept, whereby the accumulation of damage (such as DNA breaks or oxidised bases) may cause biological systems to fail, or to the programmed ageing concept, whereby internal processes (such as DNA telomere shortening) may cause ageing.

The discovery, in 1934, that calorie restriction can extend lifespan by 50% in rats has motivated research into delaying and preventing ageing.

Human beings and members of other species, especially animals, necessarily experience ageing and mortality. In contrast, many species can be considered immortal: for example, bacteria fission to produce daughter cells, strawberry plants grow runners to produce clones of themselves, and animals in the genus Hydra have a regenerative ability with which they avoid dying of old age.

Even within humans and other mortal species, there are arguably cells with the potential for immortality: cancer cells which have lost the ability to die when maintained in cell culture such as the HeLa cell line, and specific stem cells such as germ cells (producing ova and spermatozoa).[3] In artificial cloning, adult cells can be rejuvenated back to embryonic status and then used to grow a new tissue or animal without ageing.[4] Normal human cells however die after about 50 cell divisions in laboratory culture (the Hayflick Limit, discovered by Leonard Hayflick in 1961).

After a period of near perfect renewal (in humans, between 20 and 35 years of age), ageing is characterised by the declining ability to respond to stress, increasing homeostatic imbalance and the increased risk of disease. This currently irreversible series of changes inevitably ends in death.

A number of characteristic ageing symptoms are experienced by a majority or by a significant proportion of humans during their lifetimes.

Dementia becomes more common with age.[15] About 3% of people between the ages of 6574 have dementia, 19% between 75 and 84 and nearly half of those over 85 years of age.[16] The spectrum includes mild cognitive impairment and the neurodegenerative diseases of Alzheimer's disease, cerebrovascular disease, Parkinson's disease and Lou Gehrig's disease. Furthermore, many types of memory decline with ageing, but not semantic memory or general knowledge such as vocabulary definitions, which typically increases or remains steady until late adulthood[17] (see Ageing brain). Intelligence may decline with age, though the rate may vary depending on the type and may in fact remain steady throughout most of the lifespan, dropping suddenly only as people near the end of their lives. Individual variations in rate of cognitive decline may therefore be explained in terms of people having different lengths of life.[18] There are changes to the brain: after 20 years of age there is a 10% reduction each decade in the total length of the brain's myelinated axons.[19]

Age can result in visual impairment, whereby non-verbal communication is reduced,[20] which can lead to isolation and possible depression. Macular degeneration causes vision loss and increases with age, affecting nearly 12% of those above the age of 80.[21] This degeneration is caused by systemic changes in the circulation of waste products and by growth of abnormal vessels around the retina.[22]

A distinction can be made between "proximal ageing" (age-based effects that come about because of factors in the recent past) and "distal ageing" (age-based differences that can be traced back to a cause early in person's life, such as childhood poliomyelitis).[18]

Ageing is among the greatest known risk factors for most human diseases.[2] Of the roughly 150,000 people who die each day across the globe, about two thirds100,000 per daydie from age-related causes. In industrialised nations, the proportion is higher, reaching 90%.[23][24][25]

At present, the biological basis of ageing is unknown, even in relatively simple and short-lived organisms. Less still is known about mammalian ageing, in part due to the much longer lives in even small mammals such as the mouse (around 3 years). A primary model organism for studying ageing is the nematode C. elegans, thanks to its short lifespan of 23 weeks, the ability to easily perform genetic manipulations or suppress gene activity with RNA interference, and other factors.[26] Most known mutations and RNA interference targets that extend lifespan were first discovered in C. elegans.[27]

Factors that are proposed to influence biological ageing[28] fall into two main categories, programmed and damage-related. Programmed factors follow a biological timetable, perhaps a continuation of the one that regulates childhood growth and development. This regulation would depend on changes in gene expression that affect the systems responsible for maintenance, repair and defence responses. Damage-related factors include internal and environmental assaults to living organisms that induce cumulative damage at various levels.[29]

There are three main metabolic pathways which can influence the rate of ageing:

It is likely that most of these pathways affect ageing separately, because targeting them simultaneously leads to additive increases in lifespan.[31]

The rate of ageing varies substantially across different species, and this, to a large extent, is genetically based. For example, numerous perennial plants ranging from strawberries and potatoes to willow trees typically produce clones of themselves by vegetative reproduction and are thus potentially immortal, while annual plants such as wheat and watermelons die each year and reproduce by sexual reproduction. In 2008 it was discovered that inactivation of only two genes in the annual plant Arabidopsis thaliana leads to its conversion into a potentially immortal perennial plant.[32]

Clonal immortality apart, there are certain species whose individual lifespans stand out among Earth's life-forms, including the bristlecone pine at 5062 years[33] (however Hayflick states that the bristlecone pine has no cells older than 30 years), invertebrates like the hard clam (known as quahog in New England) at 508 years,[34] the Greenland shark at 400 years,[35] fish like the sturgeon and the rockfish, and the sea anemone[36] and lobster.[37][38] Such organisms are sometimes said to exhibit negligible senescence.[39] The genetic aspect has also been demonstrated in studies of human centenarians.

In laboratory settings, researchers have demonstrated that selected alterations in specific genes can extend lifespan quite substantially in yeast and roundworms, less so in fruit flies and less again in mice. Some of the targeted genes have homologues across species and in some cases have been associated with human longevity.[40]

Caloric restriction and exercise are two ways to activate autophagy and inhibit mTOR which can help resolve common age-related health problems.[citation needed]

Caloric restriction substantially affects lifespan in many animals, including the ability to delay or prevent many age-related diseases.[80] Typically, this involves caloric intake of 6070% of what an ad libitum animal would consume, while still maintaining proper nutrient intake.[80] In rodents, this has been shown to increase lifespan by up to 50%;[81] similar effects occur for yeast and Drosophila.[80] No lifespan data exist for humans on a calorie-restricted diet,[54] but several reports support protection from age-related diseases.[82][83] Two major ongoing studies on rhesus monkeys initially revealed disparate results; while one study, by the University of Wisconsin, showed that caloric restriction does extend lifespan,[84] the second study, by the National Institute on Ageing (NIA), found no effects of caloric restriction on longevity.[85] Both studies nevertheless showed improvement in a number of health parameters. Notwithstanding the similarly low calorie intake, the diet composition differed between the two studies (notably a high sucrose content in the Wisconsin study), and the monkeys have different origins (India, China), initially suggesting that genetics and dietary composition, not merely a decrease in calories, are factors in longevity.[54] However, in a comparative analysis in 2014, the Wisconsin researchers found that the allegedly non-starved NIA control monkeys in fact are moderately underweight when compared with other monkey populations, and argued this was due to the NIA's apportioned feeding protocol in contrast to Wisconsin's truly unrestricted ad libitum feeding protocol. [86] They conclude that moderate calorie restriction rather than extreme calorie restriction is sufficient to produce the observed health and longevity benefits in the studied rhesus monkeys.[87]

In his book How and Why We Age, Hayflick says that caloric restriction may not be effective in humans, citing data from the Baltimore Longitudinal Study of Aging which shows that being thin does not favour longevity.[need quotation to verify][88] Similarly, it is sometimes claimed that moderate obesity in later life may improve survival, but newer research has identified confounding factors such as weight loss due to terminal disease. Once these factors are accounted for, the optimal body weight above age 65 corresponds to a leaner body mass index of 23 to 27.[89]

Alternatively, the benefits of dietary restriction can also be found by changing the macro nutrient profile to reduce protein intake without any changes to calorie level, resulting in similar increases in longevity.[90][91] Dietary protein restriction not only inhibits mTOR activity but also IGF-1, two mechanisms implicated in ageing.[52] Specifically, reducing leucine intake is sufficient to inhibit mTOR activity, achievable through reducing animal food consumption.[92][93]

The Mediterranean diet is credited with lowering the risk of heart disease and early death.[94][95] The major contributors to mortality risk reduction appear to be a higher consumption of vegetables, fish, fruits, nuts and monounsaturated fatty acids, i.e., olive oil.[96]

The amount of sleep has an impact on mortality. People who live the longest report sleeping for six to seven hours each night.[97][98] Lack of sleep (<5 hours) more than doubles the risk of death from cardiovascular disease, but too much sleep (>9 hours) is associated with a doubling of the risk of death, though not primarily from cardiovascular disease.[99] Sleeping more than 7 to 8 hours per day has been consistently associated with increased mortality, though the cause is probably other factors such as depression and socioeconomic status, which would correlate statistically.[100] Sleep monitoring of hunter-gatherer tribes from Africa and from South America has shown similar sleep patterns across continents: their average sleeping duration is 6.4 hours (with a summer/winter difference of 1 hour), afternoon naps (siestas) are uncommon, and insomnia is very rare (tenfold less than in industrial societies).[101]

Physical exercise may increase life expectancy.[102] People who participate in moderate to high levels of physical exercise have a lower mortality rate compared to individuals who are not physically active.[103] Moderate levels of exercise have been correlated with preventing aging and improving quality of life by reducing inflammatory potential.[104] The majority of the benefits from exercise are achieved with around 3500 metabolic equivalent (MET) minutes per week.[105] For example, climbing stairs 10 minutes, vacuuming 15 minutes, gardening 20 minutes, running 20 minutes, and walking or bicycling for 25 minutes on a daily basis would together achieve about 3000 MET minutes a week.[105]

Avoidance of chronic stress (as opposed to acute stress) is associated with a slower loss of telomeres in most but not all studies,[106][107] and with decreased cortisol levels. A chronically high cortisol level compromises the immune system, causes cardiac damage/arterosclerosis and is associated with facial ageing, and the latter in turn is a marker for increased morbidity and mortality.[108][109] Stress can be countered by social connection, spirituality, and (for men more clearly than for women) married life, all of which are associated with longevity.[110][111][112]

The following drugs and interventions have been shown to retard or reverse the biological effects of ageing in animal models, but none has yet been proven to do so in humans.

Evidence in both animals and humans suggests that resveratrol may be a caloric restriction mimetic.[113]

As of 2015 metformin was under study for its potential effect on slowing ageing in the worm C.elegans and the cricket.[114] Its effect on otherwise healthy humans is unknown.[114]

Rapamycin was first shown to extend lifespan in eukaryotes in 2006 by Powers et al. who showed a dose-responsive effect of rapamycin on lifespan extension in yeast cells.[115] In a 2009 study, the lifespans of mice fed rapamycin were increased between 28 and 38% from the beginning of treatment, or 9 to 14% in total increased maximum lifespan. Of particular note, the treatment began in mice aged 20 months, the equivalent of 60 human years.[116] Rapamycin has subsequently been shown to extend mouse lifespan in several separate experiments,[117][118] and is now being tested for this purpose in nonhuman primates (the marmoset monkey).[119]

Cancer geneticist Ronald A. DePinho and his colleagues published research in mice where telomerase activity was first genetically removed. Then, after the mice had prematurely aged, they restored telomerase activity by reactivating the telomerase gene. As a result, the mice were rejuvenated: Shrivelled testes grew back to normal and the animals regained their fertility. Other organs, such as the spleen, liver, intestines and brain, recuperated from their degenerated state. "[The finding] offers the possibility that normal human ageing could be slowed by reawakening the enzyme in cells where it has stopped working" says Ronald DePinho. However, activating telomerase in humans could potentially encourage the growth of tumours.[120]

Most known genetic interventions in C. elegans increase lifespan by 1.5 to 2.5-fold. As of 2009[update], the record for lifespan extension in C. elegans is a single-gene mutation which increases adult survival by tenfold.[27] The strong conservation of some of the mechanisms of ageing discovered in model organisms imply that they may be useful in the enhancement of human survival. However, the benefits may not be proportional; longevity gains are typically greater in C. elegans than fruit flies, and greater in fruit flies than in mammals. One explanation for this is that mammals, being much longer-lived, already have many traits which promote lifespan.[27]

Some research effort is directed to slow ageing and extend healthy lifespan.[121][122][123]

The US National Institute on Aging currently funds an intervention testing programme, whereby investigators nominate compounds (based on specific molecular ageing theories) to have evaluated with respect to their effects on lifespan and age-related biomarkers in outbred mice.[124] Previous age-related testing in mammals has proved largely irreproducible, because of small numbers of animals and lax mouse husbandry conditions.[citation needed] The intervention testing programme aims to address this by conducting parallel experiments at three internationally recognised mouse ageing-centres, the Barshop Institute at UTHSCSA, the University of Michigan at Ann Arbor and the Jackson Laboratory.

Several companies and organisations, such as Google Calico, Human Longevity, Craig Venter, Gero,[125]SENS Research Foundation, and Science for Life Extension in Russia,[126] declared stopping or delaying ageing as their goal.

Prizes for extending lifespan and slowing ageing in mammals exist. The Methuselah Foundation offers the Mprize. Recently, the $1 Million Palo Alto Longevity Prize was launched. It is a research incentive prize to encourage teams from all over the world to compete in an all-out effort to "hack the code" that regulates our health and lifespan. It was founded by Joon Yun.[127][128][129][130][131]

Different cultures express age in different ways. The age of an adult human is commonly measured in whole years since the day of birth. Arbitrary divisions set to mark periods of life may include: juvenile (via infancy, childhood, preadolescence, adolescence), early adulthood, middle adulthood, and late adulthood. More casual terms may include "teenagers," "tweens," "twentysomething", "thirtysomething", etc. as well as "vicenarian", "tricenarian", "quadragenarian", etc.

Most legal systems define a specific age for when an individual is allowed or obliged to do particular activities. These age specifications include voting age, drinking age, age of consent, age of majority, age of criminal responsibility, marriageable age, age of candidacy, and mandatory retirement age. Admission to a movie for instance, may depend on age according to a motion picture rating system. A bus fare might be discounted for the young or old. Each nation, government and non-governmental organisation has different ways of classifying age. In other words, chronological ageing may be distinguished from "social ageing" (cultural age-expectations of how people should act as they grow older) and "biological ageing" (an organism's physical state as it ages).[132]

In a UNFPA report about ageing in the 21st century, it highlighted the need to "Develop a new rights-based culture of ageing and a change of mindset and societal attitudes towards ageing and older persons, from welfare recipients to active, contributing members of society."[133] UNFPA said that this "requires, among others, working towards the development of international human rights instruments and their translation into national laws and regulations and affirmative measures that challenge age discrimination and recognise older people as autonomous subjects."[133] Older persons make contributions to society including caregiving and volunteering. For example, "A study of Bolivian migrants who [had] moved to Spain found that 69% left their children at home, usually with grandparents. In rural China, grandparents care for 38% of children aged under five whose parents have gone to work in cities."[133]

Population ageing is the increase in the number and proportion of older people in society. Population ageing has three possible causes: migration, longer life expectancy (decreased death rate) and decreased birth rate. Ageing has a significant impact on society. Young people tend to have fewer legal privileges (if they are below the age of majority), they are more likely to push for political and social change, to develop and adopt new technologies, and to need education. Older people have different requirements from society and government, and frequently have differing values as well, such as for property and pension rights.[134]

In the 21st century, one of the most significant population trends is ageing.[135] Currently, over 11% of the world's current population are people aged 60 and older and the United Nations Population Fund (UNFPA) estimates that by 2050 that number will rise to approximately 22%.[133] Ageing has occurred due to development which has enabled better nutrition, sanitation, health care, education and economic well-being. Consequently, fertility rates have continued to decline and life expectancy have risen. Life expectancy at birth is over 80 now in 33 countries. Ageing is a "global phenomenon," that is occurring fastest in developing countries, including those with large youth populations, and poses social and economic challenges to the work which can be overcome with "the right set of policies to equip individuals, families and societies to address these challenges and to reap its benefits."[136]

As life expectancy rises and birth rates decline in developed countries, the median age rises accordingly. According to the United Nations, this process is taking place in nearly every country in the world.[137] A rising median age can have significant social and economic implications, as the workforce gets progressively older and the number of old workers and retirees grows relative to the number of young workers. Older people generally incur more health-related costs than do younger people in the workplace and can also cost more in worker's compensation and pension liabilities.[138] In most developed countries an older workforce is somewhat inevitable. In the United States for instance, the Bureau of Labor Statistics estimates that one in four American workers will be 55 or older by 2020.[138]

Among the most urgent concerns of older persons worldwide is income security. This poses challenges for governments with ageing populations to ensure investments in pension systems continues in order to provide economic independence and reduce poverty in old age. These challenges vary for developing and developed countries. UNFPA stated that, "Sustainability of these systems is of particular concern, particularly in developed countries, while social protection and old-age pension coverage remain a challenge for developing countries, where a large proportion of the labour force is found in the informal sector."[133]

The global economic crisis has increased financial pressure to ensure economic security and access to health care in old age. In order to elevate this pressure "social protection floors must be implemented in order to guarantee income security and access to essential health and social services for all older persons and provide a safety net that contributes to the postponement of disability and prevention of impoverishment in old age."[133]

It has been argued that population ageing has undermined economic development.[139] Evidence suggests that pensions, while making a difference to the well-being of older persons, also benefit entire families especially in times of crisis when there may be a shortage or loss of employment within households. A study by the Australian Government in 2003 estimated that "women between the ages of 65 and 74 years contribute A$16 billion per year in unpaid caregiving and voluntary work. Similarly, men in the same age group contributed A$10 billion per year."[133]

Due to increasing share of the elderly in the population, health care expenditures will continue to grow relative to the economy in coming decades. This has been considered as a negative phenomenon and effective strategies like labour productivity enhancement should be considered to deal with negative consequences of ageing.[140]

In the field of sociology and mental health, ageing is seen in five different views: ageing as maturity, ageing as decline, ageing as a life-cycle event, ageing as generation, and ageing as survival.[141] Positive correlates with ageing often include economics, employment, marriage, children, education, and sense of control, as well as many others. The social science of ageing includes disengagement theory, activity theory, selectivity theory, and continuity theory. Retirement, a common transition faced by the elderly, may have both positive and negative consequences.[142] As cyborgs currently are on the rise some theorists argue there is a need to develop new definitions of ageing and for instance a bio-techno-social definition of ageing has been suggested.[143]

With age inevitable biological changes occur that increase the risk of illness and disability. UNFPA states that,[136]

"A life-cycle approach to health care one that starts early, continues through the reproductive years and lasts into old age is essential for the physical and emotional well-being of older persons, and, indeed, all people. Public policies and programmes should additionally address the needs of older impoverished people who cannot afford health care."

Many societies in Western Europe and Japan have ageing populations. While the effects on society are complex, there is a concern about the impact on health care demand. The large number of suggestions in the literature for specific interventions to cope with the expected increase in demand for long-term care in ageing societies can be organised under four headings: improve system performance; redesign service delivery; support informal caregivers; and shift demographic parameters.[144]

However, the annual growth in national health spending is not mainly due to increasing demand from ageing populations, but rather has been driven by rising incomes, costly new medical technology, a shortage of health care workers and informational asymmetries between providers and patients.[145] A number of health problems become more prevalent as people get older. These include mental health problems as well as physical health problems, especially dementia.

It has been estimated that population ageing only explains 0.2 percentage points of the annual growth rate in medical spending of 4.3% since 1970. In addition, certain reforms to the Medicare system in the United States decreased elderly spending on home health care by 12.5% per year between 1996 and 2000.[146]

Positive self-perception of health has been correlated with higher well-being and reduced mortality in the elderly.[147][148] Various reasons have been proposed for this association; people who are objectively healthy may naturally rate their health better than that of their ill counterparts, though this link has been observed even in studies which have controlled for socioeconomic status, psychological functioning and health status.[149] This finding is generally stronger for men than women,[148] though this relationship is not universal across all studies and may only be true in some circumstances.[149]

As people age, subjective health remains relatively stable, even though objective health worsens.[150] In fact, perceived health improves with age when objective health is controlled in the equation.[151] This phenomenon is known as the "paradox of ageing." This may be a result of social comparison;[152] for instance, the older people get, the more they may consider themselves in better health than their same-aged peers.[153] Elderly people often associate their functional and physical decline with the normal ageing process.[154][155]

The concept of successful ageing can be traced back to the 1950s and was popularised in the 1980s. Traditional definitions of successful ageing have emphasised absence of physical and cognitive disabilities.[156] In their 1987 article, Rowe and Kahn characterised successful ageing as involving three components: a) freedom from disease and disability, b) high cognitive and physical functioning, and c) social and productive engagement.[157]

The ancient Greek dramatist Euripides (5th century BC) describes the multiply-headed mythological monster Hydra as having a regenerative capacity which makes it immortal, which is the historical background to the name of the biological genus Hydra. The Book of Job (c. 6th century BC) describes human lifespan as inherently limited and makes a comparison with the innate immortality that a felled tree may have when undergoing vegetative regeneration.[158]

See more here:
Ageing - Wikipedia, the free encyclopedia

Broadway Chiropractic-Wellness

1410 Broadway New York, NY

Includes:

Thorough consultation with the doctor, Complete spinal examination, 2 X-rays (if necessary),and Report of findings Hours Monday 11:00 AM - 7:00 PM Tuesday 11:00 AM - 7:00 PM Wednesday 8:00 AM - 7:00 PM Thursday 11:00 AM - 7:00 PM Friday 8:00 AM - 3:00 PM Saturday Closed Sunday Closed Services Acupressure, Acupuncture, Chiropractic Traction Therapy, Chiropractic Treatment for Injuries, Chiropractors, Disc Herniation Treatment, Emergency Chiropractic Care, Flexion-Distraction Therapy, Holistic Chiropractic Care, Homeopathic Medicine, Massage Therapy, Mobile Chiropractic Care, Pain Management, Pediatric Chiropractic, Physical Therapy

Roger A. Costa, DC

165 West End Avenue, # 1F New York, NY

Bradley Lipton DC

1 W 34th st. New York, NY

Petracco Chiropractic Center

218 Newark Avenue Jersey City, NJ

Dr. Barry Goldstein

130 W 42nd St #604 New York, NY

New York Chiropractic Life

91 Central Park W. New York, NY

Laura Gross

West 52nd Street New York, NY

Mike Berkley

West 57th Street New York, NY

Dorene Hyman

West 29th St. New York, NY

Heather B Noonan M.S.,L. Ac.

428 West 56 Street New York, NY

Read the original here:
Acupuncture Secaucus NJ - acupuncture, Secaucus NJ ...

New York Times bestseller

Cameron Diaz follows up her #1 New York Times bestseller, The Body Book, with a personal, practical, and authoritative guide that examines the art and science of growing older and offers concrete steps women can take to create abundant health and resilience as they age.

Cameron Diaz wrote The Body Book to help educate young women about how their bodies function, empowering them to make better-informed choices about their health and encouraging them to look beyond the latest health trends to understand their bodies at the cellular level. She interviewed doctors, scientists, nutritionists, and a host of other experts, and shared what shed learnedand what she wished shed known twenty years earlier.

Now Cameron continues the journey she began, opening a conversation with her peers on an essential topic that that for too long has been taboo in our society: the aging female body. In The Longevity Book, she shares the latest scientific research on how and why we age, synthesizing insights from top medical experts and with her own thoughts, opinions, and experiences.

The Longevity Book explores what history, biology, neuroscience, and the womens health movement can teach us about maintaining optimal health as we transition from our thirties to midlife. From understanding how growing older impacts various bodily systems to the biological differences in the way aging effects men and women; the latest science on telomeres and slowing the rate of cognitive decline to how meditation heals us and why love, friendship, and laughter matter for health, The Longevity Book offers an all-encompassing, holistic look at how the female body agesand what we can all do to age better.

Excerpt from:
Longevity Book - amazon.com

The majority of cancer patients use complementary therapies such as herbs and dietary supplements. Although figures differ, surveys indicate that as many as 60 percent of people with cancer take two or more dietary supplements daily.

About Herbs App

The About Herbs mobile app provides you with comprehensive, objective information about herbs, botanicals, supplements, complementary therapies, and more.

Determining whether herbs, vitamins, and other over-the-counter dietary supplements would be helpful or harmful to you can be challenging. Will a substance work as the label states it will? Is it likely to interact with your cancer medicines? Is it worth the cost?

Memorial Sloan Kettering Cancer Centers About Herbs database, a tool for the public as well as healthcare professionals, can help you figure out the value of using common herbs and other dietary supplements.

A pharmacist and botanicals expert manages and continually updates the database with assistance from other MSK Integrative Medicine Service experts, providing you with objective and evidence-based information that can be helpful in judging a products:

Herbs, Botanicals & Other Products: FAQs

Many people have questions about using herbs, vitamins, and other dietary supplements during cancer treatment, or as a preventive measure. Find our experts answers to common questions.

Its important to tell your doctor or another qualified professional that you are using a dietary supplement. The reason for this is that an active ingredient in the product could interact with increase or lessen the effect of other medicines youre taking.

People undergoing treatment for cancer should not receive any dietary supplements unless theyre prescribed by a doctor or given as part of a clinical trial thats received Institutional Review Board approval.

The United States Food and Drug Administration (FDA) does not evaluate the safety and labeling of dietary supplements before they are sold. Also, the clinical effects of these products are often difficult to predict due to lack of human data. The potencies of herbal supplements are influenced by plants or plant parts used, harvesting and processing methods, and the amounts of active compounds absorbed. We encourage you to discuss any safety concerns with your doctor before using these products.

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About Herbs, Botanicals & Other Products | Memorial Sloan ...

At Penn Medicine, complementary or integrative medicine and wellness services supplement traditional cancer treatments. Integrative Medicine may supplement your traditional treatment services, such as chemotherapy, surgery and radiation therapy. Integrative Medicine may provide ways to enhance the quality of your life, minimize or reduce side effects of cancer and cancer treatment, and promote your healing and recovery.

Our physicians at Penn Medicine's Abramson Cancer Center are knowledgeable and supportive of complementary cancer treatments. Our cancer team works with you and your family to integrate these supportive programs into the overall care plan, while ensuring your health and safety.

Our range of integrative supportive services is designed to help you cope with the cancer experience and improve your overall sense of well-being.

Services include:

For additional questions or assistance with scheduling, please contact our Integrative Oncology Patient Navigator, Laura Galindez, MSW, LSW at (215) 360-0580 or laura.galindez@uphs.upenn.edu.

Research being conducted at Penn Medicine tests the effects and mechanisms of promising health behaviors and integrative therapeutic approaches for symptom management and wellness promotion in cancer.

Additionally, through our educational programs, you will become empowered with the information to make informed decisions about your cancer care.

Researchers at Penn are exploring ways to best incorporate integrative therapies safely and effectively into the conventional medical therapies to create patient-centered care for optimal health and healing.

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Integrative Medicine and Wellness Abramson Cancer Center

We have an array of treatment approaches and we use any and all of them in the programs we give our patients to be pain free and achieve their wellness objectives. If you or someone you care for has been hurt in a crash or other kind of accident, contact us or come in and we will support you to the best of our abilities with our dedicated service.

At Integrative Physical Medicine we offer an array of services not found in most healthcare settings. Our ability to offer the best in medical and alternative treatments in one location means that our patients have more options. Our team will work with you to develop a treatment plan that makes sense for you.

Schedule a free consultation today with our medical care team so that we can get a better understanding of your needs. We will work with you one on one to help you overcome the pain you are experiencing.

We look forward to hearing from you! Make An Appointment Today.

I feel so much better.

Amazing staff at the Winter Haven location! I showed up crying late on a Wednesday night and they took me right in and took care of me with no problem. They

Intergrative physical medicine of Winter Haven Fl. has great service and its filled with helpful and loving people. From the minute you walk in your greeted

Integrative Physical Medicine of Winter The place is great. Its a wonderful environment with a great staff.

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Awesome staff. Always willing to help. I am always willing to share my experience.

Great care from a wonderful staff at the Winterhaven location.

I love this place! The staff is awesome!!!

Thank you for helping my father after his car accident. Your staff was efficient, patient, understanding, and sometimes funny!

The entire staff is absolutely the best! Everyone is kind, patient, understanding and knowledgeable about therapy. Whether a car accident or medical issues,

Im here to tell every one this is by far the best place for physical therapy. My experience here has been nothing but the best from staff to Drs there

Amazing staff at the Winter Haven location! I showed up crying late on a Wednesday night and they took me right in and took care of me with no problem. They

The whole entire staff here are great I would recommend more people to this business because they are the best

Intergrative physical medicine of Winter Haven Fl. has great service and its filled with helpful and loving people. From the minute you walk in your greeted

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Been coming for a few weeks and my experience has been phenomenal. Staff is always friendly and willing to help. I work in primary care and always refer my

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Integrative Physical Medicine of Orlando is a great office, with flexible and convenient hours for patients to come before or after work and even on lunch

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They are so professional and on top of everything here. Love the staff love equipment and love how they all work together like a well oiled machine. Wish I

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Integrative Physical Medicine Office Locations: DEBARY | KISSIMMEE POINCIANA | LAKE MARY | MAITLAND | MOUNT DORA | ORLANDO | OVIEDO | WINTER HAVEN

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Integrative Physical Medicine - Pain Relief

Welcome to the Department of Integrative Medicineand Cancer Support Communityat Orlando Health. We believe that conventional western medicine is the best approach to combat cancer and other diseases, but there are complementary paths to aid healing by treating the whole person in a cohesive balance of mind, body, and spirit. The Integrative Medicine Program engages patients and their families to become active participants in improving their physical, emotional, and social health. The ultimate goals are to optimize quality of life, overall health, and clinical outcomes through personalized evidence-based complementary approaches and research based education. As part of this initiative to treat the whole person, we are pleased to announce that we have become an official affiliate of the Cancer Support Community.

The Cancer Support Community is an international non-profit dedicated to providing support, education, and hope to people affected by cancer for over 30 years. In July 2009, The Wellness Community and Gildas Club Worldwide joined forces to become the Cancer Support Community. The Wellness Community was founded by Dr. Harold Benjamin in Santa Monica, California in 1982. Gilda Radner, famous for her work in the original Saturday Night Live cast, was a participant at The Wellness Community. The first Gildas Club opened in New York City in 1995 in her memory by her friends and family including her husband, actor Gene Wilder, and her therapist Joanne Bull. The Cancer Support Community offers a network of personalized services and education at no charge for all people affected by cancer through an affiliate network.

Orlando Health provides this program for all people impacted by cancer in the Central Florida area. The mission of the Cancer Support Community perfectly complements that of Orlando Health: to ensure that all people impacted by cancer are empowered by knowledge, strengthened by action, and sustained by community. The program addresses the social and emotional health of people at any age along the cancer continuum, including at diagnosis, treatment, post-treatment, long-term survivorship, end-of-life and bereavement to ensure no one has to face cancer alone. Novel technologies, including mobile, are also being explored to help extend the reach of these meaningful resources. Please review the link below for latest calendar of events available this month from the Cancer Support Community.

For any questions or to contact the Cancer Support Community team, please call 321.841.5056 or emailcancersupportcommunity@orlandohealth.com

If you would like more information about the Department of Integrative Medicine, please call us at 321.841.5056.

To schedule an appointment for acupuncture or oncology massage, please call the Integrative Medicine Department at 321.841.5056 or email integrativemedicine@orlandohealth.com

On the 5th floor of the Cancer Center and through the Cancer SupportCommunityprogramwe offer an Artist in Residence program that allows patients receiving infusion therapy to paint in their room or join a class to engage in art therapy.

This program is offered in collaboration with Baker Barrios Architects and the Orlando Health Foundation.

There is no trouble so great or grave that cannot be much diminished by a nice cup of tea. Bernard-Paul Heroux, 1900's Basque philosopher

Once a week and for special events at the Cancer Center, British tea is poured into elegant bone china cups to provide respite from the daily pace of life in a soothing space.High tea is served every Thursday from 2:00 to 3:00 pm in the fifth floor day room. Join us and experience the beauty and elegance of high tea.

Walking the labyrinth helps me to hold an uncertain future. Patient family member

Modeled after the labyrinth at Chartres Cathedral near Paris, France, the labyrinth is located on the fourth floor terrace of UF Health Cancer Center Orlando Health. We were the 2nd hospital in the country to begin offering a labyrinth for its patient/families, staff and local community. The labyrinth is an ancient healing tool used as a walking meditation or embodied prayer. Ninety-eight percent of walkers report feeling more peaceful after walking this simple path.

Walking the labyrinth can have a calming and restorative effect on blood pressure and stress levels.

The labyrinth is available to walk weekdays from 7 am to 6 pm.

More:
Cancer Support Community & Integrative Medicine

The following symptoms of diabetes are typical. However, some people with type 2 diabetes have symptoms so mild that they go unnoticed.

Common symptoms of diabetes:

Early detection and treatment of diabetes can decrease the risk of developing the complications of diabetes.

Women with gestational diabetes often have no symptoms, which is why it's important for at-risk women to be tested at the proper time during pregnancy.

Learn more about gestational diabetes.

Have you already been diagnosed with diabetes but are concerned about symptoms that may be the result of complications related to diabetes?

Visit the Complications section.

You may also be interested in our book, Uncomplicated Guide To Diabetes' Complications, 3rd Edition

Do you have questions or concerns about diabetes symptoms? Want to connect with others? Visit the American Diabetes Association Community to find support now!

If you've recently been diagnosed with type 2 diabetes, enroll in the FREE Living With Type 2 Diabetes program to get more information and support.

The rest is here:
Diabetes Symptoms: American Diabetes Association

Help Make A Difference: Donate Today to Support a Cure!

Every 23 seconds, someone is diagnosed with diabetes. Diabetes causes more deaths a year than breast cancer and AIDS combined. It must be stopped!

Your gift today will go a long way in helping us save lives and continue to lead the search for a cure, so that one day we can be free of diabetes and its burdens.

Honor someone you love or remember someone you've lost with a gift in their name.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Fill out the form to make a one-time gift of $25 or more and receive 200 miles from eMiles.

Help cure diabetes. We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $350,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

We're making tremendous strides to advance crucial diabetes research. But we have an epidemic on our hands and time is precious. We need far more resources to speed life-changing diabetes research that will provide better treatments and, one day, a cure.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Your support is vital. Please donate today to support diabetes research.

We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $200,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

This special matching gift offer is brought to you by our campaign sponsor, Amaranth Diabetes Foundation. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

Help cure diabetes. We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $350,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

We're making tremendous strides to advance crucial diabetes research. But we have an epidemic on our hands and time is precious. We need far more resources to speed life-changing diabetes research that will provide better treatments and, one day, a cure.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Your support is vital. Please donate today to support diabetes research.

We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $200,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

This special matching gift offer is brought to you by our campaign sponsor, Amaranth Diabetes Foundation. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

Help cure diabetes. We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $350,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

We're making tremendous strides to advance crucial diabetes research. But we have an epidemic on our hands and time is precious. We need far more resources to speed life-changing diabetes research that will provide better treatments and, one day, a cure.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Your support is vital. Please donate today to support diabetes research.

Earn 1,000 Points from MyPoints by making a tax-deductible gift of $15 or more.

We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. The Amaranth Diabetes Foundation will match your contribution, dollar-for-dollar, up to campaign total of $200,000. Please don't wait, donate today - we only have until June 24th to meet this goal.

Earn 1,000 Points from MyPoints by making a tax-deductible gift of $15 or more.

This special matching gift offer is brought to you by our campaign sponsor, Amaranth Diabetes Foundation. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. Our generous partner, Visionworks, will match your contribution, dollar-for-dollar, up to campaign total of $50,000. Please don't wait, donate today - we only have until August 15 to meet this goal.

We're making tremendous strides to advance crucial diabetes research, and prevent and cure diabetes. But we have an epidemic on our hands and time is precious. We need far more resources to speed life-changing diabetes research that will provide better treatments and, one day, a cure.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Your support is vital. Please donate today to support diabetes research.

We're happy to announce that Visionworks is demonstrating its support of the American Diabetes Association with an offer to match every donation to this appeal dollar for dollar up to a campaign total of $50,000! Donate today we have until August 15 to meet this goal.

This matching gift offer is brought to you by Visionworks. Visionworks, a leading provider of eye care services, is committed to helping people with diabetes lead healthy lives. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

We have an incredible opportunity to DOUBLE the impact of your support for critical diabetes research. Our generous partner, Visionworks, will match your contribution, dollar-for-dollar, up to campaign total of $50,000. Please don't wait, donate today - we only have until August 15 to meet this goal.

We're making tremendous strides to advance crucial diabetes research, and prevent and cure diabetes. But we have an epidemic on our hands and time is precious. We need far more resources to speed life-changing diabetes research that will provide better treatments and, one day, a cure.

UPDATE: For a limited time every dollar you give will be MATCHED x2 ($1 you give = $3!)

Your support is vital. Please donate today to support diabetes research.

We're happy to announce that Visionworks is demonstrating its support of the American Diabetes Association with an offer to match every donation to this appeal dollar for dollar up to a campaign total of $50,000! Donate today we have until August 15 to meet this goal.

This matching gift offer is brought to you by Visionworks. Visionworks, a leading provider of eye care services, is committed to helping people with diabetes lead healthy lives. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

Honor a loved one with a donation in their name for Father's Day. Make a tax deductible gift now to help Stop Diabetes.

Your tax-deductible gift will fund critical diabetes research, education and awareness programs that will improve the lives of those with diabetes. Your gift includes the choice of an email or print announcement card for your gift recipient.

Honor a loved one with a donation in their name. Make a tax deductible gift now to help Stop Diabetes.

Please use our Memorial Donation Form if you would like to create a memorial in the name of a beloved family member or friend. If you prefer, you may make your donation by phone at 1-800-DIABETES (1-800-342-2383) or by mail.

This special matching gift offer is brought to you by our campaign sponsor, Amaranth Diabetes Foundation. We are grateful for their support of the American Diabetes Association and people with diabetes. Donations to this matching gift campaign will be directed 100% to Association-funded diabetes research. Donations or contributions to Step Out: Walk to Stop Diabetes, Tour de Cure, or other special event fundraising campaigns do not qualify for this matching gift offer.

Help give the gift of diabetes summer camp to a child like yours.

Give a child living with diabetes the life-changing experience of spending a whole week having fun and learning how to better manage this tough disease with other kids who all have diabetes, too.

It's tough to feel like you're the only person in the world who has to deal with diabetes, but then you go to camp. Camp is a place where I feel safe and people understand what I'm going through. When I'm there, everyone gets it, no one stares and there's no explanation necessary.

Help give the gift of diabetes summer camp to a child like yours.

Give a child living with diabetes the life-changing experience of spending a whole week having fun and learning how to better manage this tough disease with other kids who all have diabetes, too.

It's tough to feel like you're the only person in the world who has to deal with diabetes, but then you go to camp. Camp is a place where I feel safe and people understand what I'm going through. When I'm there, everyone gets it, no one stares and there's no explanation necessary.

In the next 48 hours, 7,670 Americans will be diagnosed with diabetes, changing their lives forever. There's no sugarcoating itdiabetes is bad news. It makes everything harderfrom eating a meal to staying healthy to being treated fairly at work and school and so much more.

That's why we want to show these people that they're not alone during what is probably a very tough time in their lives. Show them that you stand with them by making a gift to help fight this devastating disease. No matter how much youre able to give, your tax-deductible gift will help speed the search for a cure and improve care for people living with diabetes, as well as prevent more Americans from developing this deadly disease. #GiveForDiabetes

In the next 48 hours, 7,670 Americans will be diagnosed with diabetes, changing their lives forever. There's no sugarcoating itdiabetes is bad news. It makes everything harderfrom eating a meal to staying healthy to being treated fairly at work and school and so much more.

STANDING TOGETHER OUR WONDERFUL SUPPORTERS

Fill out the fields to put your pin in the map!

Read more:
American Diabetes Association: 2016 Help Cure Diabetes v1 ...

What will they be when they grow out?

by Diane Brucato-Thomas, RDH, EF, BS, FAADH

To be or not to be? That is the question was likely uttered on the stage at the Shakespeare Festival next door to where we sat on a blanket on the Lithia Park grass, in Ashland, Oregon. We were contemplating the backgammon board between us, as leaves sprinkled down, in the crisp autumn air. Apparently, the backgammon board was not all that Jack was contemplating. A similar question left his lips, Diane, when does the will begin?

Uh, well ... uuhhhhh ... Now, there was a question that I had not thought much about. Jack was good at snatching those kinds of questions out of thin air. Sometimes, I thought he used them as a means of distraction if I was winning, so I would make a dumb move. But then, his letters were the same way: How many drops of water does it take to fill a swimming pool? and he would go about figuring it out step by brilliant step in the body of the letter.

I came back to the question at hand and darn near gave away the game. I never was good at multitasking. Jack looked at me. Well? Does a plant have a will when it turns toward the light? Does a protozoa have a will? Does the will begin before or after the brain develops? Does a sperm cell have a will when it starts its journey with such seeming determination? Or does the will begin when the fertilized egg starts to divide? Or is it when the cells differentiate, determining their purpose within the organism? Exactly when does the will begin?

We ended up going round and round on that one, on that breezy fall day in 1984.

Fifteen years before I met this brilliant man, who could conjure scientific facts and philosophical dilemmas on a whim, Jack was diagnosed with Parkinson's disease. He was far from being alone. Parkinson's is a very common neurodegenerative disorder, found to affect 2% of the population over age 65. Actor Michael J. Fox brought Parkinson's more into the limelight when he was diagnosed at a much younger age. It is caused by a progressive degeneration and loss of neurons in the brain that produce dopamine. The symptoms include tremors, abnormally decreased mobility (hypokinesia), and rigidity. I remember Jack holding my arm as his feet would shuffle to a slow start, just to walk from here to there.

Jack died in 1996.

How I would love to have the opportunity to have a deep discussion with Jack today! Parkinson's disease may be among the first diseases to be well-suited to treatment using stem cell transplantation. Methods to induce embryonic stem cells to differentiate into cells with many of the functions of specific dopamine-producing neuron cells have been successfully developed in several laboratories.

Jack would have been fascinated to learn that recently scientists directed mouse embryonic stem cells to differentiate into dopamine-producing neurons and then transplanted them into the brains of a rat model of Parkinson's disease. These stem cell derived neurons reinnervated the brains of the rat Parkinson model, released dopamine, and improved their motor function!

Scientists are now developing a number of strategies in the laboratory for producing dopamine-releasing neurons from human adult stem cells to be transplanted into humans with Parkinson's disease. If the generation of an unlimited supply of dopamine-producing neurons is successful, neurotransplantation may be widely available for Parkinson's patients in the future.

Parkinson's disease is just one of many previously incurable diseases and conditions that may find a cure in stem cell regenerative therapies. Muscular dystrophy, Alzheimer's disease, osteoporosis, diabetes, cardiovascular disease, renal failure, and spinal cord injuries are a few others. Virtually any disease that occurs as a result of damaged, failing or malfunctioning tissues may potentially be cured through regenerative therapies.

Stem cells from one part of the body will be expanded (grown out) and reimplanted to replace an entirely different type of tissue. This type of transplant will totally negate the need for antirejection drugs, since the implant is made of the patient's own body cells.

Most recently, the very first engineered whole organ transplant, using a windpipe made with the patient's own stem cells, was successfully completed by surgeons in Spain. The patient was a 30-year-old woman, whose airways were damaged by tuberculosis and who needed the transplant to save her lung.

The doctors removed a trachea and bronchus from a donor patient who recently died. Using strong chemicals and enzymes, all of the cells were dissolved from the donor trachea, leaving only a fibrous tissue scaffolding made of collagen protein. This structure was used as the framework to repopulate with the woman's own cells. The doctors used two types of the woman's own cells to populate the scaffold cells lining her own windpipe, and very immature bone marrow cells (adult stem cells), which could be encouraged to form the kind of cells that normally surround the trachea.

The repopulated scaffold was rotated in a special bioreactor and after only four days of growth in the lab, the newly-coated donor trachea was ready for transplant. It looked and behaved identically as a normal human donor trachea would. This was cut to fit and replaced the woman's damaged windpipe. Four days after the transplant, the hybrid trachea was almost indistinguishable from the adjacent normal airway. Further, there was no sign of rejection four months later.

The idea of using stem cells from the person's own body to provide undifferentiated mesenchymal cells, not only circumvents the necessity for antirejection medication, it entirely avoids the controversy of using embryonic stem cells. Most exciting for us in the dental field is that undifferentiated mesenchymal cells originated from the cranial ectoneuromesioderm can be found in the pulp of teeth! These stem cells may be used to produce tissues found from the neck up, including nerves, bone, cartilage, and fat.

This discovery prompted Dr. Greg Chotkowski, an oral surgeon whose own son suffers from muscular dystrophy, to look at the plethora of extracted teeth being discarded daily in an entirely new light. Here was a noninvasive source of magical adult stem cells readily available for patients' future access. This realization led Dr. Chotkowski to create StemSave, a company that provides an opportunity for dentists and patients to recover and cryogenically preserve their own or their child's healthy stem cells for future regenerative purposes. This is an incredible gift of life to offer for your child's future health.

One of my favorite clients is a smart and beautiful 30-year-old mother from Brazil. She was showing me a picture of her darling 10-month-old son, when she cited her gratefulness that he was born in good health. She told me that, at the time when she gave birth, she had been reading about stem cell therapies and research being done, and asked the nurses at her hospital about banking the umbilical stem cells. Surprisingly, she was told that it was too difficult and, therefore, was not given the opportunity. Imagine, this woman was thrilled to hear from me that there would be another opportunity when her little boy began to lose his baby teeth.

Deciduous teeth that are just starting to loosen, particularly incisors or canines, with more than one-third of the root structure intact, are perfect candidates for viable pulpal stem cell recovery. The tooth must be free of infection, deep caries, and have an intact blood supply. Mesodens or supernumerary teeth are another ideal source. Extracted permanent teeth, such as wisdom teeth or bicuspids extracted for orthodontic purposes can also be a source for adult stem cells, as long as the teeth are free of infection or pathology, have a complete root, and intact blood supply.

If a client chooses to bank their dental stem cells, they can enroll online at http://www.stemsave.com. Their dentist will then receive a recovery and transport kit in time for the extraction appointment. When the tooth is removed from the oral cavity at 98.6 degrees, the dentist places the tooth or teeth into a vial included in the recovery kit. This is then placed into a thermos containing a patented phase change material that maintains the internal environment of the thermos at room temperature, inducing hypothermia. UPS is dispatched through StemSave for immediate pickup and delivery within 48 hours. This is critical to keep the pulp alive.

When StemSave receives the package, the teeth are removed and disinfected. Then they are cracked open, and the pulp is removed and tested for viability. The dental stem cells are then cryogenically preserved in liquid nitrogen utilizing DMSO as a cryoprotectant. DMSO prevents crystallization damage within the cells, so, even though frozen, the cells remain undamaged in suspended animation at a cryopreservation facility that has been in business for 25 years.

At this point in time, studies involving the applicability of adult stem cells derived from dental pulp has focused on proving the viability of these cells for regenerative applications. Less invasive than extracting stem cells from conventional sources, such as bone marrow and umbilical cords, dental pulp stem cell extraction is an attractive and less expensive alternative.

Jeremy Mao, DDS, PhD, a professor and director of the Tissue Engineering and Regenerative Medicine Laboratory and professor of dentistry at Columbia University, states that, although more clinical research and differentiation studies are needed involving dental stem cells, the future holds a great potential for the use of these cells. Clinical research of the potential for utilizing these cells in the treatment of diseases or conditions involving neural, bone, cartilage, or fat is just beginning.

Dr. Mao's latest announcement states in an abstract that he has turned dental stem cells into pancreatic beta islet cells that produce insulin. Considering the fact that the occurrence of diabetes in the United States is reaching epidemic proportions, this is most exciting!

Since the very beginning of the profession of dental hygiene, dental hygienists were known as specialists in prevention. In recent years, as periodontal diseases have become linked with systemic diseases, dental hygienists are being touted as not only saving teeth, but saving lives! Now, dental hygienists are in the unique position to not only save lives, but actually play a role in improving the quality of and extending lives.

Dental hygienists see almost every client that comes in the door. How many of these adults need an extraction?

How many college kids are having their wisdom teeth extracted? How many teens are getting orthodontic extractions? How many little tykes are anxiously awaiting the tooth fairy? How many new mothers like my client were denied an opportunity to bank their umbilical stem cells? Imagine the fact that encouraging the simple banking of those viable dental stem cells may save and extend their lives in the event of an unfortunate disease or condition occurring. Talk about making a difference!

Now that I've got your attention, stay tuned. The sequel to this article will go into more depth to help you understand the miraculous life-giving science of stem cells and regenerative medicine.

This brings me back to Jack. I found a couple of letters he wrote to my husband. In this one from 1988, Jack relates that his cousin once asked:

You say, And so you are 70 and have your own hell with that Parkinson's disease.' Has the happiness in your life been worth the suffering?

Jack answered:

My whole life, practically, has been a wonderful experience. Somehow I escaped the thistle and thorns. The accent on my existence has been exploring and knowing. I find the times we live in now most fascinating.

I never planned on an immortal existence ... Man and other living things go through a cycle of birth, life, and death. I remember, as a youngster, asking the question: What is the mechanism for gathering together the residue of ashes or bacterial decay and reconstituting it into a loving sentient being? A shriveled shell of 75 or an improved new young model?'

In another letter from December 1981, Jack writes: How often do you pause to marvel at the new things of recent years? ... sending a space craft to Jupiter and having thousands of pictures sent back, putting a man on the moon, releasing nuclear energy, the wonders of electronics ... Who needs (more) miracles? We've got all we need ... and real ones.

These contemplations make me wish Jack were here now. I would gladly give up winning the backgammon game to discuss the amazing potential of stem cell therapy, regenerative medicine, and the hope of life without the debilitating symptoms. What a way to spend the day!

Originally posted here:
Stem Cells - Registered Dental Hygienist - RDH Mag

Recommended Preventative Medicine Guidelines for Giraffe (Giraffa camelopardalis sp.),

Preventative medicine is key to providing long-term health care for all animals, including giraffe (Giraffa camelopardalis sp.). Use of a preventative program helps to avoid intra- and inter- specific infectious disease, developmental problems, and in the long term management is cost effective.

Giraffe are commonly kept in zoological facilities and generally present few problems. In many instances however, giraffe can be difficult to clinically manage, due to the mechanics of dealing with a megavertebrates. Operant conditioning, even with limited physical facilities, may assist with the evaluation of captive giraffe and is encouraged. A preventative health care plan should also address the social and psychological needs og the individuals and the group as a whole. Activities that stimulate normal behaviors have beneficial physical effects on the animals and make for better display animals as well. Use of browse is strongly encouraged for this and other health effects addressed in the nutritional section.

Giraffe are difficult animals to physically examine due to the inherent dangers of manual and chemical restraint.1-3 In general, current recommendations advise against yearly immobilization for physical examinations until safe methods for routine sedation and handling are defined. When performed, a physical examination should include;

1. Visual examination during normal ambulation for symmetry, gait, and overall appearance.

2. Verification of permanent identification (microchip, tattoo, ear tag, patterning, etc.).

3. Physical examination to include auscultation, hoof condition and wear, ophthalmic and aural exam, visual assessment of the external genitalia, haircoat density, dental assessment, EKG when possible, etc.

4. Clinicopathologic assessment;

A. Bloodwork to include:

a. Complete blood count

b. Serum chemistry panel

c. Mineral panel

d. Serology to include Leptospirosis sp (17 serovar panel- Appendix II), Malignant Catarrhal Fever, Bluetongue, Brucellosis, M. paratuberculosis, and New World West Nile virus status.

B. Routine urinalysis.

5. Estimated or actual weight.

6. Fecal analyses

A. Parasite screen- fecal flotation, direct.

B. Enteric pathogen screen; salmonella, campylobacter

C. Mycobacterium paratuberculosis surveillance- 3 fecal cultures (see Appendix).

7. Tuberculosis (TB) test- intradermal testing can be performed in the caudal tail fold with 0.1cc Bovine PPD as opportunity arises. It is not currently recommended to immobilize giraffe on a routine basis for tuberculosis screening unless clinical signs support testing, a history of tuberculosis in the herd warrants screening, or impending shipment is to occur.

8. Recommended vaccinations-

A. Giraffe are susceptible to Clostridium tetani.4 Vaccination with tetanus toxoid should be performed every other year or opportunistically.

B. Other vaccination for infectious disease (Leptospirosis sp., rabies, etc.) is left to the discretion of the institutions and perceived risks. There are no reported infections with New World West Nile virus in giraffe and vaccination is not recommended at this time.

9. Prophylactic treatments as needed

A. Ivermectin

B. Vitamin E/Selenium

C. Pyrantel tartrate

D. Fenbendazole

10. Hoof trimming

A. Some animals can be conditioned to allow routine hoof trimming in a restraint. Hoof trimming should be performed as needed to prevent long-term problems.

Parasite Control

Routine fecal examination (minimum twice yearly) should be performed on all individuals. Persistent parasitemia should be addressed with rotational anthelmintics based on a comprehensive parasite program.5-6 Larval drug resistance can be determined prior to developing any deworming program as resistance has developed in giraffe herds in certain areas. Testing can be performed with Dr. Tom Craig at Texas A&M.

Literature cited

1. Bush, M. Anesthesia of high-risk animals: Giraffe. In: (Fowler, M.E., R.E. Miller, eds.) Zoo and Wild Animal Medicine, Current Therapy 4. 1999. W.B. Saunders Co. Philadelphia, PA. Pp. 545-547.

2. Bush, M., D.G. Grobler, J.P. Raath, L.G. Phillips, M. A. Stamper and W.R. Lance. 2001. Use of medetomidine and ketamine for immobilization of free-ranging giraffes. J.A.V.M.A. 218(2): 245-249.

3. Fischer, M.T., R.E. Miller, and E.W. Houston. 1997. Serial tranquilization of a reticulated giraffe (Giraffa camelopardalis reticulata) using xylazine. J.Zoo Wildl. Med. 28(2): 182-184.

4. Nofs, S.A., T.A. Reichard, W. Shellabarger. 2002. Tetanus in a Reticulated giraffe (Giraffa camelopardalis reticulata): Observations and implications at the Toledo zoo. Proc. Am. Assoc. of Zoo Vet. Ann Conf., Milwaukwee, WI Pp. 186-190.

5. Isaza, R., G.V. Kollias. Designing a trichostrongyloid parasite control program for captive exotic ruminants. In (Fowler, M.E. and R.E. Miller, eds.). Zoo and Wild Animal Medicine. W.B. Saunders Co. Philadelphia, PA 593-597.

6. Young, K.E., J.M. Jensen, T.M. Craig. 2000. Evaluation of anthelmintic activity in captive wild ruminants by fecal egg reduction tests and a larval development assay. J. Zoo Wildl. Med. 31(3): 348-352.

Appendix I

1. Fecal specimen testing for M. paratuberculosis from giraffe.

a. Collect at least 3 grams of feces daily for 3 days. Refrigerate specimens until the third specimen is obtained, place in seal able baggies or large seal able plastic tubes, place on ice and ship via overnight express to;

Johnes Testing Center

University of Wisconsin

School of Veterinary Medicine

2015 Linden Drive, West Room 4230

Madison, WI 53706-1102

Phone (608) 265-6463

2. Serology specimens for M. paratuberculosis ELISA and AGID.

a. Collect 1cc of serum in sealable plastic tubes and send on ice to;

Johnes Testine Center

University of Wisconsin

School of Veterinary Medicine

2015 Linden Drive West, Room 4230

Madison, WI 53706-1102

Phone (608) 265-6463

Appendix II

1. Leptospire titers-

a. Collect 2cc of serum in seal able plastic tubes and send on ice sent to;

National Veterinary Services Laboratory

1800 Dayton Road

Ames, IA 50010

Phone (515) 663-7266

Read the original here:
Giraffe Preventative Medicine Guidelines - American ...

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MicroRNAscomprise a novel class of small, non-coding endogenous RNAs that regulategene expressionby directing their target mRNAs for degradation or translational repression. miRNAs represent small RNA molecules encoded in the genomesofplants and animals. These highly conserved 22 nucleotides long RNA sequences regulate the expression of genes by binding to the 3'-untranslated regions (3'-UTR) of specific mRNAs. A growing body of evidence shows that mRNAs are one of the key players in cell differentiation and growth, mobility andapoptosis.

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SimilarGenomicsandgenomicmedicinenewfieldofnaturalexaminationinwhichthegenomegroupins of variousspecies- human, mouse and a wide assortment of different life forms from yeast to chimpanzees-are looked at. The assessment of likenesses and contrasts betweengenomesof various life forms; can uncover contrasts in the middle of people and species and also transformative connections.

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Track 11:Plant Genomics

Late mechanical headways have generously extended our capacity to dissect and comprehendplantgenomes and to diminish the crevice existing in the middle of genotype and phenotype. The quick advancing field of genomics permits researchers to dissect a huge number of qualities in parallel, to comprehend the hereditary building design ofplant genomesfurthermore to separate the qualities in charge oftransformations.

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Track 12:Personal Genomics

Individualgenomicsis the branch of genomics worried with thesequencingand examination of the genome of a person. The genotyping stage utilizes diverse strategies, includingsingle-nucleotide polymorphism(SNP) examination chips or incomplete or fullgenome sequencing.

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Track 13:Microbial Genomics

MicrobialGenomicsappliesrecombinantDNA,DNAsequencingroutines,andbioinformaticsto succession, gather, and dissect the capacity and structure of genomes in organisms. Amid the previous 10 years, genomics-based methodologies have profoundly affected the field ofmicrobiologyand our comprehension of microbial species. In view of their bigger genome sizes,genome sequencingendeavors on growths and unicellular eukaryotes were slower to begin than ventures concentrated on prokaryotes.

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Track 14:Future trends in Genomics

Genomics researchholds the way to meeting a considerable lot of the difficulties of the coming years. Right now, the greatest test is in information investigation. We can produce a lot of information modestly, yet that overpowers our ability to comprehend it. The significant test of the Genome Research is we have to imbue genomic datainto restorative practice, which is truly hard.

RelatedConferences: International ConferenceonClinical and Molecular Genetics, November 28-30, 2016 Chicago, USA; 2nd International ConferenceonTranscriptomicsAugust 18-20, 2016 Portland, Oregon USA; International ConferenceonNextGenerationSequencingJuly 21-22, 2016 Berlin, Germany; The Fourteenth Asia PacificBioinformaticsConference, 11th-13 January 2016, San Francisco, USA; WorldCongress onHumanGeneticsOctober 31- November 02, 2016 Valencia, Spain; 18th International Conference onGeneticsand Genomics, June 9 - 10, 2016, San Francisco, USA; NGS 16Genome Annotation, April 4 6, 2016, Barcelona, Spain; Maintenance of Genome Stability 2016, March 7-10, 2016, Panama, Central America;Epigenomics: new marks, new horizons, December 2015, 2 December 2015, UK;Human GenomeMeeting, 28 February 2 March 2016, Houston, USA

Track15:GenomicMedicine GenomicMedicineas "a developing restorative train that includes utilizing genomicdata around a person as a major aspect of their clinical consideration (e.g., for demonstrative or remedial choice making) and the wellbeing results and strategy ramifications of that clinical use." Already, genomic medication is having an effect in the fields of oncology,pharmacology, uncommon and undiscovered maladies, and irresistible illness.

RelatedConferences: International ConferenceonMolecularandCancerBiomarkersSeptember 15-17, 2016 Berlin, Germany; 4th International ConferenceonIntegrativeBiology, July 18-20, 2016 Berlin; 7th International ConferenceonBiomarkers & Clinical Research, November 28-30, 2016 Baltimore, USA; International ConferenceonBiochemistryOctober 13-15, 2016 Kuala Lumpur, Malaysia; International Conference onProtein Engineering, October 26-28, 2015 Chicago, USA;BiomarkerSummit, 2123 March 2016, San Diego, United States; 18th International ConferenceonBiomarkersandClinicalMedicine, 16-17 May, 2016, Paris, France; Circulating Biomarkers World Congress 2016, 21-22 March, 2016, Boston, USA; The Biomarker Conference, 18 - 19 February 2016, San Diego, USA; CancerMolecular Markers, 7-9, March 2016, San Francisco, USA

Track 16:Genomics Market

Genomics is the study of the genetic material or genomes of an organism. Analysts forecast theGlobal Genomicsmarketwill grow at a CAGR of 11.21% over the period 2013-2018. According to the report, the most important driver of the market is an increase in the demand for consumables. The growing adoption ofgenetictestingfor various applications, especially in regions such as the APAC, and an increase in genetictesting volumes in North America and Western Europe is increasing the demand for consumables.

RelatedConferences: 5th International ConferenceonComputationalSystemsBiologyAugust 22-23, 2016 Philadelphia, USA; 6th International ConferenceonBioinformaticsMarch 29-30, 2016 Valencia, Spain; 7th International Conference onBioinformaticsOctober 27-28, 2016 Chicago, USA; 2nd International Conference onTranscriptomicsAugust 18-20, 2016 Portland, Oregon USA; International ConferenceonNext GenerationSequencingJuly 21-22, 2016 Berlin, Germany; The Fourteenth Asia PacificBioinformaticsConference, 11th-13 January 2016, San Francisco, USA; 18th International Conference on Bioinformatics andBiotechnology, 19 20 May 2016, Berlin, Germany; IEEE conference onBioinformaticsandComputationalBiology, October 5-7, 2016, Chiang Mai, Thailand; 7th International ConferenceonBioinformaticsModels, MethodsandAlgorithms, 21- 23 Feb, 2016, Rome, Italy;Bio banking2016, 57 January 2016, London, United Kingdom.

OMICS International hosted3rd International Conference on Genomics & Pharmacogenomics during September 21-23, 2015 at San Antonio, USA based on the theme Implications & Impacts of Genomic Advances on Global Health.

Active participation and generous response was received from the Organizing Committee Members, scientists, researchers, as well as experts from Non-government organizations, and students from diverse groups who made this conference as one of the most successful and productive events in 2015 from OMICS Group.

The conference was marked with several workshops, multiple sessions, Keynote presentations, panel discussions and Poster sessions. We received active participation from scientists, young and brilliant researchers, business delegates and talented student communities representing more than 35 countries, who have driven this event into the path of success.

The conference was initiated with a warm welcome note by Honorable guests and the Keynote forum.The proceedings went through interactive sessions and panel discussions headed byhonorable Moderator Dr. Aditi Nadkarni, New York University, USA for the conference.

The conference proceedings were carried out through various Scientific-sessions and plenary lectures, of which the following Speakers were highlighted as Keynote speakers:

Utilizing cancer sequencing in the clinic - Best practices in variant analysis, filtering and annotation: Andreas Scherer, Golden Helix Inc., USA

The role of genomics in gene therapy and diagnostic testing and related intellectual property issues: Krishna Dronamraju, Foundation for Genetic Research, USA

Epigenesis, methylation, and single strand breaks: Rosemarie Wahl, St. Mary's University, USA

The application of validation and proficiency testing concepts from current clinical genetic diagnostics for the implementation of new genetic technologies: Kathleen S Wilson, U.T Southwestern Medical Center, USA

Biomimetic membranes: Mariusz Grzelakowski, Applied Biomimetic Inc., USA

The Genomics-2015 also being highlighted for the below International workshop:

Understanding the effects of steroid hormone exposure on regulation of P53 and Bcl-2 gene expression

OMICS Group has taken the privilege of felicitating Genomics-2015 Organizing Committee, Keynote Speakers who supported for the success of this event. OMICS Group, on behalf of the Organizing Committee congratulates the Best Poster awardees for their outstanding performance in the field of Genomics & Pharmacogenomics and appreciates all the participants who put their efforts in poster presentations and sincerely wishes them success in future endeavors.

Poster Judging was done by: Dr. Hao Mei, University of Mississippi Medical Center, USA Best Poster Award was received by: Mr. Juan Carlos Alberto Padilla, Instituto Politecnico Nacional, Mexico

Genomics-2015 attracted the Society for General Microbiology, UK and they came forward to advert their leading journals on the back side cover of conference proceedings book.

Genomics-2015 was sponsored by one of the leading bioinformatics solution center BGI Americas, USA

Genomics-2015 necessarily thanks Aeon Clinical Laboratories, USA for exhibiting recent innovations and express ways in clinical testing.

We are also obliged to various delegate experts, company representatives and other eminent personalities who supported the conference by facilitating active discussion forums. We sincerely thank theOrganizing Committee Membersfor their gracious presence, support, and assistance towards the success of Genomics-2015.

With the unique feedback from the conference,OMICS Groupwould like to announce the commencement of the "6th International Conference on Genomics & Pharmacogenomics, during September 12-14, 2016 at Berlin, Germany.

For More details visit: http://genomics.conferenceseries.com/

Genomics-2014

The conference brought together a broad spectrum of the Genomics community, educators from research universities with their programs and state colleges from across the world, as well as representatives from industry and professional geosciences societies.

This 2ndInternational Conference on Genomics and Pharmacogenomics was based on the theme Envisioning the Genomic Advances in Global Health which covered the below scientific sessions:

Functional genomics

The conference was greeted by the conference moderator Junio Cota, VTT Brasil, Brazil.The support was extended by the honorable guest Krishna Dronamraju, Foundation for Genetic Research, USA; Anton A. Komar, Cleveland State University, USA; J. Claiborne Stephens, Genomics GPS, LLC USA and energized by Keynote presentations.

This 2nd International Conference on Genomics and Pharmacogenomics uplifted with more than 30 oral presentations by researchers, scientists, professors, industry delegates and more than 6 poster participants around the globe. OMICS Group International has taken the privilege of felicitating Earth Science-2014 Organizing Committee Members, Editorial Board Members of the supported Journals and Keynote Speakers who supported for the success of this event.

Last but not the leastOMICS GroupInternational Conferences wishes to acknowledge with its deep sincere gratitude to all the supporters from the Editorial Board Members of our Open Access Journals, Keynote speakers, Honorable guests, Valuable speakers, Poster presenters, students, delegates and special thanks to the Exhibitors andMedia partnersfor their support to make this event a huge success.

With enormous feedback from the participants and supporters of 2nd International Conference on Genomics and Pharmacogenomics, OMICS Group conferences is glad to announce its 3rd International Conference on Genomics and Pharmacogenomics (Genomics-2015) event fron September 21-23, 2015 at San Antonio, USA.

Genomics-2013

The International Conference on Functional and Comparative Genomics & Pharmacogenomics (Genomics-2013) was organized by the OMICS Group during November 12-14, 2013 at DoubleTree by Hilton Hotel Chicago-North Shore, IL, USA. The conference was well received with participation from Genomics-2013 Organizing Committee Members, researchers, scientists, technologists and students from various parts of the world. The three day program witnessed thought provoking speeches from experts which focused on the theme Recent Research Methodologies and Discoveries in Genomics Era. The theme touched upon various topics like

Functional and Comparative Genomics Pharmacogenomics and Personalized medicine Evolutionary and Developmental Genomics Bioinformatics in Genomics & Proteomics Cancergenomics Epigenomics, Transcriptomics and Non-coding genomics Genome Sequencing & Mapping Plant & Ecological Genomics Biomarkers & Molecular Markers

The Conference has gathered support from The European Society of Pharmacogenomics and Theranostics (ESPT), The Nestle Institute of Health Sciences and Geneticational.

Genomics-2013 has swirl up the scientific thoughts on various current genome research related areas. The conference has shown scope of pharmacogenomics (studies of how variations in the human genome affect response to the drugs) and its implications in global health and pharma industry. The conference focused on how pharmacogenomics aids in diagnosing genetic information thus helping to predict not only patients drug response but also many other effects like adverse drug effects and their interactions and the diseases related to that gene. The conference was initiated with a series of invited lectures delivered by both Honorable Guests and members of the Keynote Forum.

Clyde A. Hutchison, Distinguished Investigator from J. Craig Venter Institute, USA who helped in determining the first complete sequence of a DNA molecule (phiX174) and developed site-directed mutagenesis with Michael Smith (1978) delivered a phenomenal and worthy keynote presentation on Building a minimal cell The JCVI design-build-test cycle for synthetic cells during the conference.

Roger Hendrix, Distinguished Professor from University of Pittsburgh, USA explained how he and his group are involved in Genomic analysis of bacteriophages.

William C. Reinhold from National Cancer Institute, NIH, USA presented his speech on The current state of comparative genomics and pharmacogenomics, and the application of the NCI-60 resources and CellMiner tools to these problems.

The conference was chaired by Alexander Bolshoy, Yasuo Iwadate, Gil Atzmon, Gary A. Bulla, Jatinder Lamba, William C. Reinhold, Luciano Brocchieri and Ning-Sun Yang.

Along with the participants of Genomics-2013, we would like to express our gratitude to Dr. Alexander Bolshoy and Dr. William C. Reinhold for their extreme support and assistance towards the conference.

Students from various parts of the world took active participation in poster presentations. Mr. Aren Ewing and Mr. Chih-Yao Hsu were awarded with best posters for their outstanding contribution.

OMICS Group also took the privilege of felicitating Genomics-2013 Organizing Committee, Editorial Board Members of Journal of Data Mining in Genomics and Proteomics, Journal of Pharmacogenomics and Pharmacoproteomics, Journal of Phylogenetics and Evolutionary Biology and Journal of Proteomics and Bioinformatics, Keynote Speakers, Chair and Co-Chairs whose support led the conference into the path of excellence.

The warm support and suggestions from all the participants, inspires us in organizing 2nd International Conference on Genomics & Pharmacogenomics which will be held during September 08-09, 2014 Raleigh, USA.

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Worlds Leading Genomics Conference | Global Meetings ...

The Ophthalmology Residency at Interfaith Medical Center is an AOA accredited program administered along with St. John's Episcopal Hospital, Far Rockaway, New York which is the sponsoring hospital.

The goal of the program is to train Osteopathic Physicians to become proficient in diagnosing and treating patients with ophthalmic pathology, both medically and surgically. The osteopathic philosophy of patient care is stressed throughout the training years. The residency is 36 months in duration and will provide the resident with the didactic and clinical training required to become competent and compassionate ophthalmologists. Most residents enroll in Fellowships in various ophthalmic subspecialties upon completion of the program.

Prospective residents must be graduates of an AOA accredited School of Osteopathic Medicine. In addition, they must have completed an AOA accredited internship. Prospective residents apply for the residency through ERAS during their senior year of medical school.

Residents will rotate through both St. John's Episcopal Hospital and Interfaith Medical Center and will attend to patients in the outpatient clinics, operating rooms, ER as well as inpatient care and consultation. There are also out of hospital rotations that the residents participate in. The residents will be expected to assume increasing responsibilities in ophthalmic care as they progress through the program.

The residents will be expected to complete the American Academy of Ophthalmology's Basic and Clinical Science Course. In addition, they are required to take the annual OKAP in-service exam in each year of training. Didactics will be given daily by the faculty. The residents also attend weekly Grand Rounds at the New York Eye and Ear Infirmary, and in addition attend the weekly Greater New York Ophthalmology Clinical Lecture Series and the OKAP Board Review Course, both given in the evenings in Manhattan. There are required Osteopathic Practice and Principals symposia that the residents attend. Residents are required to participate in independent research projects during their training years. Finally, the residents are encouraged to attend many Ophthalmology symposia that are given in the New York metropolitan area.

The faculty of the program is dedicated to ensuring that the educational goals of the program are achieved. Upon successful completion of the residency, the physician will be qualified to take the Board Certification exam in Ophthalmology given by the American Osteopathic Board of Ophthalmology.

For any questions regarding the program call 718.869.7815

Information for Medical Residency Applicants

Read more here:
Opthalmology Residency at Interfaith Medical Center

Welcome to Allaman Eye Care Medical Group. We are a comprehensive ophthalmology practice conveniently located in Santa Cruz, California. With a board-certified ophthalmologist and two fully licensed optometrists, we strive to provide the highest quality of eye care in a friendly, welcoming environment by combining advanced skill and years of experience.

Our doctors are dedicated to helping patients of all ages improve, preserve and maintain the health of their eyes with specialized treatment of many eye diseases and conditions. We also provide full optometry services, with an in-house optical shop, to fulfill your unique vision needs.

Welcome to Allaman Eye Care Medical Group. We are a comprehensive ophthalmology practice conveniently located in Santa Cruz, California. With a board-certified ophthalmologist and two fully licensed optometrists, we strive to provide the highest quality of eye care in a friendly, welcoming environment by combining advanced skill and years of experience.

Our doctors are dedicated to helping patients of all ages improve, preserve and maintain the health of their eyes with specialized treatment of many eye diseases and conditions. We also provide full optometry services, with an in-house optical shop, to fulfill your unique vision needs.

More here:
Eye Care Medical Group Inc - Opthalmology Santa Cruz CA