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Conference looks at the medical possibilies of using adult stem cells – Florida Times-Union

February 6th, 2017 9:47 am

In 2014, when Springer Publications published Stem Cells in Aesthetic Procedures, the first book ever published on the subject, Jacksonville physician Lewis Obi contributed a chapter, Specialized Stem Cell Fat Transfer to Face.

At places like the Mayo Clinic, researchers have been looking at the possibilities that stem cells could someday help repair damaged organs.

But Obi, a veteran plastic surgeon, already has been using stem cells, harvested from a patients own fat, in a number of procedures in recent years. He has become an ardent champion of the potential stem cells have in regenerative medicine. While stem cells extracted from bone marrow have been used in the past, Obi said there are actually more stem cells in fat than in bone marrow and they are easier to harvest

The current use of stem cells and the potential of stem cells will be the subject of a two day symposium by the Cell Surgical Network of Florida, an organization Obi founded. The symposium will be held Thursday and Friday at Memorial Hospital.

Presenters during the conference include three Jacksonville physicians, Obi, orthopedic surgeon David Heekin and anesthesiologist and pain management specialisit Orlando Florette. Heekin will talk about the orthopedic uses of stem cells and Florette will talk about the use of stem cells in pain management.

Another presenter will be Hee Young Lee, a Korean physician who invented Maxstem, a totally enclosed system which processes adult fat into large numbers of viable stem cells. Obi has used these cells in both his plastic surgery practice as well as in regenerative medicine.

Stuart Williams, a researcher with the University of Louisville, will discuss issues with the Food and Drug Administration, which has been reluctant to approve the use of stem cells to treat many conditions that stem cell advocates believe could be treated effectively with stem cells.

Mark Berman, co-author of the 2015 book The Stem Cell Revolution and co-founder of the Cell Surgical Network, the nations largest stem cell network, is scheduled to appear via Skype to talk about using stem cells to mitigate the effects of concussions.

Thursday will feature asesssions on preparing and storing stem cells and bioprinting. Friday will feature 12 presentations, the last being a panel discussion by nine faculty members.

For more about the conference and about the Cell Surgical Network of Florida, go to http://www.stemcellsurgeryflorida.com.

Charlie Patton: (904) 359-4413

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How a person’s own fat could one day treat diabetes – Knowridge Science Report

February 6th, 2017 9:47 am

Scientists have extracted stem cells from a 50-year-old test subjects fatty tissue and applied genetic reprogramming to make them mature into functional beta cells.

The feat brings them a step closer to a personalized repair kit for diabetes.

In the presence of glucose, the beta cells generated using this genetic software produce the hormone insulinjust like natural beta cells, which are found in the pancreas.

The researchers report the findings in Nature Communications.

The team, led by Martin Fussenegger, professor of biotechnology and bioengineering in ETH Zurichs department of biosystems science and engineering, took the stem cells and added a highly complex synthetic network of genesthe genetic software.

They designed this network to precisely recreate the key growth factors involved in this maturation process.

Central to the process are the growth factors Ngn3, Pdx1, and MafA. Concentrations of these factors change during the differentiation process. For instance, MafA is not present at the start of maturation.

Only on day four, in the final maturation step, does it appear, its concentration rising steeply and then remaining at a high level.

The changes in concentration of Ngn3 and Pdx1, however, are very complex: while the concentration of Ngn3 rises and then falls again, the level of Pdx1 rises at the beginning and towards the end of maturation.

Fussenegger stresses that it is essential to reproduce these natural processes as closely as possible in order to produce functioning beta cells: The timing and the quantities of these growth factors are extremely important.

In Fusseneggers opinion, it is a real breakthrough that a synthetic gene network has been successfully used to achieve genetic reprogramming that delivers beta cells.

Until now, scientists have controlled such stem cell differentiation processes by adding various chemicals and proteins using pipettes.

Its not only really hard to add just the right quantities of these components at just the right time, its also inefficient and impossible to scale up, Fussenegger says.

In contrast, the new process can successfully transform three out of four adipose stem cells into beta cells.

These beta cells look very similar to their natural counterpartsboth kinds contain dark spots known as granules, which store insulin. In addition, the artificial beta cells function in a very similar way.

At the present time, the quantities of insulin they secrete are not as great as with natural beta cells, he admits.

In the future, the new technique might make it possible to implant new functional beta cells in diabetes sufferers that are made from their own adipose tissue.

While beta cells have been transplanted in the past, this has always required subsequent suppression of the recipients immune systemas with any transplant of donor organs or tissue.

With our beta cells, there would likely be no need for this action, since we can make them using endogenous cell material taken from the patients own body, says Fussenegger.

This is why our work is of such interest in the treatment of diabetes.

To date, the ETH researchers have only cultured their beta cells; they have yet to implant them in someone with diabetes.

This is because they first wanted to test whether stem cells could be fully differentiated from start to finish using genetic programming.

Fussenegger is convinced that this new method could also be used to produce other cells.

Stem cells taken from adipose tissue could be differentiated into various cell types, he says, and most people have an overabundance of fat from which these stem cells can be harvested.

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News source: ETH Zurich. The content is edited for length and style purposes. Figure legend: This Knowridge.com image is for illustrative purpose only.

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How diet influences colon cancer – Knowridge Science Report

February 6th, 2017 9:47 am

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer.

Now, a study from MIT reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous.

The study of mice suggests that a high-fat diet drives a population boom of intestinal stem cells and also generates a pool of other cells that behave like stem cells.

This means they can reproduce themselves indefinitely and differentiate into other cell types.

These stem cells and stem-like cells are more likely to give rise to intestinal tumors, says Omer Yilmaz, an MIT assistant professor of biology and leader of the research team.

Not only does the high-fat diet change the biology of stem cells, it also changes the biology of non-stem-cell populations, which collectively leads to an increase in tumor formation, says Yilmaz, who is a member of MITs Koch Institute for Integrative Cancer Research and a gastrointestinal pathologist at Massachusetts General Hospital.

Under a high-fat diet, these non-stem cells acquire the properties of stem cells so that when they are transformed they become tumorigenic, says David Sabatini, an MIT professor of biology, member of the Whitehead Institute, and investigator with the Howard Hughes Medical Institute.

Sabatini and Yilmaz, who previously collaborated on research into the effects of caloric restriction on stem cell potential in the intestine, are the senior authors of the study, which appears in Nature.

Exploring cancer risk

People who are obese have a greater risk of developing colorectal cancer, according to previous studies.

Yilmaz lab, which studies the relationship between diet and cancer, set out to uncover the cellular mechanisms underpinning the enhanced risk of colon cancer.

Recent studies have shown that intestinal stem cells, which last a lifetime, are the cells most likely to accumulate the mutations that give rise to colon cancer.

These stem cells live in the lining of the intestine, known as the epithelium, and generate all of the different cell types that make up the epithelium.

To investigate a possible link between these stem cells and obesity-linked cancer, Yilmaz and colleagues fed healthy mice a diet made up of 60 percent fat for nine to 12 months.

This diet, Yilmaz noted, is much higher in fat than the typical American diet, which is usually about 20 to 40 percent fat.

During this period, the mice on the high-fat diet gained 30 to 50 percent more body mass than mice fed a normal diet, and they developed more intestinal tumors than mice on a normal diet.

These mice also showed some distinctive changes in their intestinal stem cells, the researchers discovered.

First, they found that the mice on a high-fat diet had many more intestinal stem cells than mice on a normal diet. These stem cells were also able to operate without input from neighboring cells.

Normally, intestinal stem cells are surrounded by support or niche cells, which regulate stem cell activity and tell them when to generate stem cells or differentiated cells.

However, the stem cells from mice on a high-fat diet were more able to function on their own;

when they were removed from the mice and grown in a culture dish without their niche cells, they gave rise to mini-intestines much more readily than intestinal stem cells from mice on a normal diet.

Expanding the pool

The researchers also found that another population known as progenitor cells differentiated daughter cells of stem cells started to behave like stem cells:

They began to live much longer than their usual lifespan of a few days, and they could also generate mini-intestines when grown outside of the body.

This is really important because its known that stem cells are often the cells in the intestine that acquire the mutations that go on to give rise to tumors, Yilmaz says.

Not only do you have more of the traditional stem cells (on a high-fat diet), but now you have non-stem-cell populations that have the ability to acquire mutations that give rise to tumors.

The researchers also identified a nutrient-sensing pathway that is hyperactivated by the high-fat diet.

The fatty acid sensor known as PPAR-delta responds to high levels of fat by turning on a metabolic process that enables cells to burn fat as an energy source instead of their usual carbohydrates and sugars.

Indeed, small-molecule agonists of PPAR-delta mimic the effects of a high-fat diet in animals fed a normal diet, Sabatini says.

In addition to activating this metabolic program, PPAR-delta also appears to turn on a set of genes that are important for stem cell identity, Yilmaz says.

His lab is now further investigating how this happens in hopes of identifying possible cancer drug targets for tumors that arise in obesity.

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News source: MIT. The content is edited for length and style purposes. Figure legend: This Knowridge.com image is credited to MIT News.

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Study shows stem cells could treat hair loss – WNDU-TV

February 6th, 2017 9:47 am

A new clinical study is offering hope for folks who suffer from hair loss. The treatment: stem cells.

Americans spend between one and four billion dollars a year treating hair loss. It's a problem that affects around 56 million people in this country. Now, four surgeons in the U.S. are testing a stem cell treatment in a non-surgical procedure, and overseas trials in Japan and Egypt are already showing some success.

Roy Woelke knows how overwhelming hair loss can be. He's been dealing with it for 30 years.

I noticed thinning in my late 20s, and it never stops. It seems like it just goes on and on, he said.

Hes had three hair replacement surgeries, but thats really just moving hair around the head, and as he says, you run out of supply. Dr. Kenneth Williams may have new hope for Roy and millions of others. Hes running a clinical trial that uses stem cells and platelet-rich plasma, or PRP, to treat baldness.

The study is taking cells that are in our body that help to regenerate or stimulate inactive or dormant hair follicles. That is the theory behind what were doing this procedure on.

Doctor Williams takes fat from the abdomen, emulsifies it and separates the stem cells, mixes it with the patients own plasma which has been spun down to be super concentrated. Then with 300 shots, he injects the mixture into the scalp, twice over a three month period. Roy hopes to get into the trial, which has five participants so far. Dr. Williams already does the procedure for paying patients whove had promising results.

Those patients are seeing some differences in the density of the hair. Were waiting for the final results, which takes 9 to 12 months after the administration. We look to see the final results of what were doing," Dr. Williams explained.

Dr. Williams hopes to publish results in two years.

His trial is supported by National Institutes of Health, but not by a major pharmaceutical company yet. That means his trial is patient-funded, meaning theyll pay a reduced cost of the $2,500 to $5,800 procedure, depending on which arm of the trial is chosen.

-- Research Summary

Background: Around 70 percent of men and 40 percent of women are impacted by hair loss. Two- thirds of American men will suffer from some kind of hair loss by the age of 35. By the age of 50, 85 percent of American men will experience thinning of their hair. The process begins for 25 percent of men during their twenties, and even though it is a common process that occurs naturally, like aging, most men and women are unhappy and would do anything to fix or delay the process. Hair loss can occur for different reasons like disease, reaction to medications and stressful events; however, heredity is most often the cause of hair loss. (Source: http://www.americanhairloss.org/men_hair_loss/introduction.asp & http://www.straandstudy.com)

Treatments: American hair loss sufferers have spent around $3.5 billion combined in treatments. If a treatment is not FDA approved or recommended by the AHLA (American Hair Loss Association), it may not be a safe option for your scalp or hair. The key to treating hair loss or hair thinning is treating it early. The two popular options recommended by the AHLA are medication or surgery, like propecia, and/or surgical hair restoration. (Source: http://www.americanhairloss.org/men_hair_loss/treatment.asp)

Straand Study: Dr. Kenneth Williams is currently running a clinical trial that will hopefully help and delay hair loss. Unlike any other form of current treatment, Dr. Williams is focusing on stem cells and platelet-rich plasma, or PRP, to treat baldness. The study consists of taking stem cells that are already in the body to regenerate or stimulate inactive hair follicles. Studies show that stem cells residing in the scalp remain at recurrent numbers but in balding patients, the conversion of stem cells to progenitor cells required for follicle growth is reduced. The goal of this study is to stimulate hair to become active and to be able to grow again. In the non-surgical procedure, Dr. Williams takes fat from the abdomen of the patient. The stem cells are separated from the fat cells by emulsification. The stem cells are then mixed with the patients plasma and the mixture is injected 300 times into the scalp of the patient twice in the span of three months. With the current five participants in the study, the results have been very promising. The current trial is supported by National Institutes of Health and is patient-funded. For more information on the study or to become a participant, visit http://www.straandstudy.com. (Source: Dr. Kenneth Williams & http://www.straandstudy.com)

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Blind mom regains sight after church visit – whnt.com

February 6th, 2017 9:47 am

whnt.com
Blind mom regains sight after church visit
whnt.com
After struggling with medical issues, Gutierrez went blind in her right eye in 2012. She says she lost vision completely in both eyes in November 2015. A physician diagnosed Gutierrez with benign intracranial hypertension a condition where pressure ...

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Monday Close-Up: Finding her way – Daily Herald

February 6th, 2017 9:47 am

Daily Herald
Monday Close-Up: Finding her way
Daily Herald
Like many things, eyesight is a spectrum. 20/20 vision is considered perfect eyesight, and anything below 20/200 vision is considered legally blind (i.e. a person with perfect vision can see at 200 feet what a person with 20/200 vision can only make ...

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Diabetes crisis grips Southern California – Los Angeles Daily News – LA Daily News

February 6th, 2017 9:46 am

Sarah Cooke listened as her aging diabetic patients vented about trying to cope with the pernicious disease.

Guilt and denial, thats pretty much it, said a woman with short gray hair.

Confused, said another woman wearing wire-rimmed glasses. I dont know what I can eat and what I cant.

Cooke, a clinical dietitian at Loma Linda University Health Care, leads a weekly class as part of an effort to combat the diabetes crisis in Southern California, with elderly residents particularly vulnerable. Cooke recently discovered that about 70 percent of all patients who enter Loma Linda University Medical Center are diabetic.

The important thing is to get to people shortly after theyre diagnosed and get them the resources and proper education, she said. A lot of people have had diabetes for a number of years, have developed complications and never had the opportunity to talk to a dietitian or take a class.

After hearing the diabetic patients complaints, Cooke offers suggestions. During her nine years as a dietitian at Loma Linda, Cooke has seen an increasing number of younger patients who have pre-diabetes. She attributes this to the sodas, sugary energy and coffee drinks, and fast food that many younger people subsist on, in addition to their sedentary lifestyle.

That is translating into an onrush of suffering as these patients age, when the effects of the disease are most pronounced. Diabetes is a disease in which the bodys inability to produce any or enough of the hormone insulin causes elevated levels of glucose (or sugar) in the blood. If untreated, it can lead to hypertension, heart disease, strokes, blindness, kidney disorders, amputations and death.

Physicians anticipate the rate of diabetes among the elderly will increase sharply in the coming years. About 45 percent of all adults in the state have pre-diabetes or undiagnosed diabetes, according to a study by the UCLA Center for Health Policy Research. Up to 30 percent of those with pre-diabetes will develop Type 2 diabetes within five years.

The diabetes rate in the state has increased by 35percent since 2001, according to the study. About 13 million adults in California have pre-diabetes or diabetes and another 2.5million adults have already been diagnosed with the disease, totaling about 40percent of the states population. Nationally, annual medical spending for people with diabetes is almost twice that for people without the disease. A person who is diagnosed with diabetes by age 40 will have lifetime medical spending that is $124,600 more than someone who is not diabetic.

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Education is important in preventing and controlling diabetes, said Dr. Theodore Friedman, an endocrinologist at Martin Luther King Jr. Outpatient Center and chairman of the county Department of Health Services Endocrinology Work Group. He leads a weekly class for diabetics, most of whom are seniors, which emphasizes healthy eating and exercise. He has discovered that elderly diabetic patients are sometimes more amenable to changing their eating and unhealthy habits than younger patients, he said.

Most of my patients say they want to lose weight, he said. Many are on so many medications theyre trying to reduce the number theyre taking. They really want to change, while some younger people feel theyre invincible or theyre too busy to alter their lifestyle.

The rate of adults with diabetes in Los Angeles County (about 10 percent) is slightly higher than the state average (about 9 percent), according to the UCLA study. The county Health Department offers a number of diabetes classes, but some impoverished elderly patients dont have transportation and cant attend regularly. As a result, the department offers eleven classes, some in Spanish and English, posted on YouTube, ranging from nutrition suggestions to stress management to mixing insulin.

In the past, diabetes education was more for wealthy people, Friedman said. Now were trying to educate everyone. Were trying to get patients to get as involved as possible in managing their diabetes.

Although experts say the diabetes rate is concerning all over Southern California, the level varies from county to county. Orange Countys rate is below the state average.

Thats the case in Riverside County, too. But next door, in San Bernardino County, the diabetes-related death rate 32.4 per 100,000 population is more than 50 percent higher than the state average.

Because the problem is so severe among the elderly, extensive community outreach is needed, said Dr. Kevin Codorniz of Loma Lindas division of endocrinology, diabetes and metabolism. The classes at the Diabetes Treatment Center and at other hospitals are an important way to educate patients so they understand the disorder and change their lifestyle to avoid dangerous blood sugar levels.

Carolyn Edwards, who attended the class at Loma Linda, lives nearby in Bloomington. Edwards, 71, a retired hotel front desk manager, was diagnosed with diabetes decades ago, but never assiduously monitored her condition.

When I was working it was easier to keep my sugar levels down because I was much more active, she said. But when I retired it became much more of a challenge. I had stopped fixing meals and just snacked or went to hamburger places. Then my blood sugar went crazy and my doctor suggested I take this class.

For years Edwards had little energy and was often too weak to walk. She frequently felt so dizzy that she occasionally leaned against a wall for support and slowly slid to the floor. After two classes at the Diabetes Center, she said she has made significant changes and already feels more energetic. She now tests her blood sugar twice a day, shops and makes herself healthy dinners every night, and works out on a stationary bicycle at a gym.

Most of the people who participate in the Loma Linda class are in their fifties and older. The first class focuses on the basics of diabetes, the second on nutrition, and the third on blood sugar monitoring and reading food labels. The patients put into practice what theyve learned and then return two months later for a final class, when their weight and blood sugar levels are tested again.

Cooke recently saw a 70-year-old patient with severe diabetes who was almost 50 pounds overweight and had a number of complications, including kidney failure and hyperten-sion. When Cooke asked the woman about her eating habits, the woman mentioned that she consumed eight tortillas. A day? Cooke asked. No, the woman said. Each meal.

That meant she was eating 24 tortillas every day, Cooke said. The woman thought that since tortillas arent sweet, they wouldnt be bad for her diabetes. She didnt realize this was way too much carbohydrates and carbohydrates break down into sugar.

Cooke immediately signed the woman up for a diabetes class.

Corwin writes for the Center for Health Reporting at the Leonard D. Schaeffer Center for Health Policy & Economics at the University of Southern California. Research for the story was supported by the Gary and Mary West Foundation.

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Diabetes among the most expensive American diseases, as drug … – Sacramento Bee

February 6th, 2017 9:46 am

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Stellar Biotechnologies Congratulates Partner’s Decision to Extend Drug Development for Diabetes – Yahoo Finance

February 6th, 2017 9:46 am

LOS ANGELES, Feb. 6, 2017 /PRNewswire/ --Stellar Biotechnologies, Inc. (SBOT), a leading manufacturer of a key protein utilized in multiple immunotherapy development pipelines targeting cancers, Alzheimer's and lupus, among other diseases, today issued a statement congratulating Neovacs S.A. for its decision to extend the development of its lupus drug for Type 1 diabetes.

Neovacs, a collaboration partner utilizing Stellar's KLH protein as a carrier molecule for its Kinoid treatment, announced in a press release that it would begin preclinical proof-of-concept studies in diabetes this year, with the objective of entering clinical studies in the first half of 2018. Type 1 diabetes is an autoimmune disease, which affects 25 million people worldwide, according to the World Health Organization. Lupus affects approximately 5 million people globally.

"We extend our congratulations to Neovacs on this promising news and the continuing advancement of their Kinoid technology," said Stellar President and CEO Frank Oakes. "The large patient populations of lupus, and now diabetes, underscore the need for us to prepare Stellar to be in a position to provide significantly larger supplies of our pharmaceutical-grade KLH products."

To this end, Stellar has ongoing initiatives to expand its infrastructure and production capacity to manufacture multi-kilogram quantities of its Stellar KLH products. In addition, last year, Stellar and Neovacs announced formation of a joint venture, Neostell S.A.S., for manufacturing immunotherapy products for Neovacs and potentially other third-party customers utilizing KLH-based therapeutic vaccines. Therapeutic vaccines represent a new class of treatments, known as active immunotherapies, which are designed to stimulate a patient's own immune system to generate an immune response to target and attack an existing disease or condition.

About Stellar Biotechnologies Based north of Los Angeles at the Port of Hueneme, Stellar Biotechnologies, Inc. (SBOT) is the leader in sustainable manufacture of Keyhole Limpet Hemocyanin (KLH), an important immune-stimulating protein used in wide-ranging therapeutic and diagnostic markets. KLH is both an active pharmaceutical ingredient (API) in many new immunotherapies (targeting cancer, immune disorders, Alzheimer's and inflammatory diseases) as well as a finished product for measuring immune status. Stellar is unique in its proprietary methods, facilities, and KLH technology. The company is committed to meeting the growing demand for commercial-scale supplies of GMP grade KLH, ensuring environmentally sound KLH production, and developing KLH-based active immunotherapies. Stellar KLH is a trademark of Stellar Biotechnologies.

Follow Stellar: LinkedIn | Twitter | Facebook | Google+

Stellar Forward-Looking Statements This press release may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements may be identified by the use of words such as "anticipate," "believe," "plan," "estimate," "expect," "intend," "may," "will," "would," "could," "should," "might," "potential," or "continue" and variations or similar expressions. Readers should not unduly rely on these forward-looking statements, which are not a guarantee of future performance. There can be no assurance that forward-looking statements will prove to be accurate, as all such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause actual results or future events to differ materially from the forward-looking statements. Such risks include, but may not be limited to: general economic and business conditions; technology changes; competition; changes in strategy or development plans; availability of funds and resources; anticipated requirements for operating capital; governmental regulations and the ability or failure to comply with governmental regulations; changes in trade policy and international law; the timing of Stellar's or its partners' anticipated results, including in connection with clinical trials; the ability to meet the goals of Stellar's joint ventures and strategic partnerships;and other factors referenced in Stellar's filings with securities regulators. For a discussion of further risks and uncertainties related to the Stellar's business, please refer to Stellar's public company reports filed with the U.S. Securities and Exchange Commission and the British Columbia Securities Commission. All forward-looking statements are made as of the date hereof and are subject to change. Except as required by law, Stellar assumes no obligation to update such statements. This press release does not constitute an offer or solicitation of an offer for sale of any securities in any jurisdiction, including the United States.

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‘Snus’ users run greater risk of type 2 diabetes – Medical Xpress

February 6th, 2017 9:46 am

February 6, 2017 Credit: iStockphoto

Consuming one or more pot of "snus" Swedish snuff or dipping tobacco per day increases the risk of developing type 2 diabetes by 70 per cent. This is the same risk increase as previously seen for smokers who smoke one packet of cigarettes a day. The study on the effects of snus was conducted by researchers at Karolinska Institutet and their colleagues at Ume and Lund universities, and is published in the Journal of Internal Medicine.

According to figures from the Public Health Agency of Sweden, 19 per cent of men and 4 per cent of women in Sweden take snus. Type 2 diabetes is also common; seven per cent of the adult population have a diabetes diagnosis and up to 20 per cent are in the risk zone. The disease is a serious one, as it can lead to complications, cardiovascular disease and premature death.

The researchers at Karolinska Institutet and Ume and Lund universities studied pooled data for a total of 54,500 men followed between the years of 1990 and 2013, during which time 2,441 of them developed type 2 diabetes. Owing to the size of the study, the team was able to estimate the effects of snus on never-smokers and thus avoid having the results contaminated by those who use both snus and cigarettes.

Confirm earlier suspicions

"We can confirm earlier suspicions that snus-users have a higher risk of type 2 diabetes, an effect that can seemingly not be explained by them being occasional smokers or having a lifestyle that is less healthy in other respects," says Sofia Carlsson, researcher at Karolinska Institutet's Institute of Environmental Medicine.

There is also a 40 per cent increase in risk at a lower level of consumption (5-6 pots a week). A possible explanation for the result is the effect of nicotine, which experimental studies have shown can impair insulin sensitivity and thus possibly increase the risk of diabetes.

Snus-users expose themselves to at least the same dose of nicotine as smokers, even though they are spared many of the other chemicals contained in cigarette smoke. No increased risk was seen in people who stopped using snus, which suggests that quitting snus can have a beneficial effect in this regard.

"Because snus is relatively uncommon amongst women, we were unable to make corresponding analyses for them, so the impact of snus on the diabetes risk for women is an important matter for future research," says Dr Carlsson.

No less dangerous than cigarettes

From a wider perspective, it is important to point out that existing research suggests that smokers are much more likely to develop cancer and cardiovascular disease than snus-users; it is in terms of type 2 diabetes that snus is no less dangerous than cigarettes.

"The diabetes trend is largely driven by lifestyle factors, so to reduce your risk of diabetes you should not use tobacco, avoid being overweight and be physically active," she says.

Explore further: Smokeless tobacco product snus may increase risk of death among prostate cancer patients

More information: S. Carlsson et al. Smokeless tobacco (snus) is associated with an increased risk of type 2 diabetes: results from five pooled cohorts, Journal of Internal Medicine (2017). DOI: 10.1111/joim.12592

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Roche won’t sell diabetes businessit’s looking for deals to boost it instead – FierceBiotech

February 6th, 2017 9:46 am

A week after Johnson & Johnson said it was weighing strategic options for its diabetes device divisions, reports emerged that Roche was doing the same with its diabetes testing unit. But diagnostics chief Roland Diggelman put an end to speculation Wednesday, saying the Swiss company wants to expand the biz, Reuters reported.

Bloomberg reported Tuesday that people familiar with the matter said Roche was considering options for its diabetes care unit, including a spinoff or a sale.

Roches diabetes care sales dropped 4% in FY 2016, thanks to pricing pressure in the U.S. But Diggelmann dismissed reports the company was considering a sale, Reuters reported. In fact, he said, the company is on the prowl for new tech that could boost the flagging business.

"We basically have all of the technologies we need in-house in varying degrees of development, so we have to ask ourselves, 'How far are we along?'" Diggelmann said, as quoted by Reuters "We're looking around: Are there new possibilities, are there alternatives?"

Roche faced similar speculation in 2015, after Bayer sold off its diabetes device unit to KKR/Panasonic. But while Roches diabetes business had had a rough couple of years, thanks

To price cuts in the U.S., Diggelmann said at the time: "It's still a good business and a business with a future.

The company markets the Accu-Chek line of devices, which includes blood glucose meters and insulin pumps. It leads the diabetes testing industry, ahead of competitors J&J, Abbott and KKR/Panasonic.

In May last year, Roche Diabetes Care inked a deal with Senseonics to sell the latters Eversense Continuous Glucose Monitoring System in Germany, Italy and the Netherlands. Senseonics system comprises a rice-sized sensor that is implanted just under the skin and measures blood glucose levels for 90 days.

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Diabetes May Be Warning Sign of Pancreatic Cancer – WebMD

February 6th, 2017 9:46 am

Jan. 31, 2017 -- Diabetes could be an early sign of pancreatic cancer, new research suggests.

A presentation to the European Cancer Congress in Amsterdam reports that 50% of people in two sample groups who had been diagnosed with pancreatic cancer had been diagnosed with type 2 diabetes in the previous year and been given their first medication to control it.

Fewer than 5 out of 100 people can expect to be alive 5 years after being diagnosed with pancreatic cancer. Survival rates are poor because the cancer doesn't usually cause any symptoms until late in the disease.

The American Cancer Society estimates more than 53,000 people will be diagnosed with pancreatic cancer in 2017.

"Although it has been known for some time that there is an association between type 2 diabetes and pancreatic cancer, the relationship between the two conditions is complex," Alice Koechlin, from the International Prevention Research Institute in Lyon, France, told the conference.

The pancreas contains cells that make insulin. Type 2 diabetes happens when these cells are unable to make enough insulin or the insulin doesn't work properly.

The study involved 368,377 people with type 2 diabetes in Belgium and 456,311 in Italy.

Among these patients over a 5-year period, there were 885 and 1,872 cases of pancreatic cancer diagnosed respectively.

The researchers found that patients had a 3.5 times higher risk of being diagnosed with pancreatic cancer compared to those on other non-insulin, non-incretin diabetes treatments in the first 3 months after their first prescription for a class of diabetes medications known as incretins. The risks decreased with time. These are hormones that stimulate the pancreas to produce more insulin.

Among patients who already had type 2 diabetes, the need to switch to injecting insulin because their condition got worse was associated with a seven-times-higher risk of being diagnosed with pancreatic cancer.

"Doctors and their diabetic patients should be aware that the onset of diabetes or rapidly deteriorating diabetes could be the first sign of hidden pancreatic cancer, and steps should be taken to investigate it," Koechlin said.

"The association between pancreatic cancer and type 2 diabetes has been an area of interest to researchers for several years, so its great to see studies generating new and potentially very valuable information which could alert clinicians to the need for further investigation in certain patients, said Maggie Blanks, chief executive of the Pancreatic Cancer Research Fund, in a statement.

"We now need the work developing early diagnostic tests to catch up so that we can make use of this information as soon as possible. There are global efforts investigating biomarkers for pancreatic cancer in blood or saliva that may have diagnostic potential and the early research that PCRF has funded which identified biomarkers in urine is progressing towards a clinical trial.

"We may well be on the cusp of a significant improvement in both identifying those at higher risk and being able to diagnose quickly, so that appropriate treatment can start as soon as possible."

These findings were presented at a medical conference. They should be considered preliminary as they have not yet undergone the "peer review" process, in which outside experts scrutinize the data prior to publication in a medical journal.

SOURCES:

2017 European Cancer Congress: "Early detection of pancreatic cancer among diabetic patients: results from prescription database analyses."

European Cancer Organisation.

Pancreatic Cancer Research Fund.

American Cancer Society.

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Study: Death likely within 5 years of loss of smell | KXAN.com – KXAN.com

February 6th, 2017 9:45 am

KXAN.com
Study: Death likely within 5 years of loss of smell | KXAN.com
KXAN.com
If you think you are losing your sense of smell, or have a family member who is, doctors say it needs to be checked out.

and more »

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To fulfill stem cell agency’s promise, consider winding it down – Sacramento Bee

February 6th, 2017 9:45 am

Sacramento Bee
To fulfill stem cell agency's promise, consider winding it down
Sacramento Bee
The stem cell agency, in fact, recently failed to raise just $75 million in new funds from private investors. Even if all stem cell clinical trials resulted in drug candidates, they would still come up against the so-called Valley of Death the term ...

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Unraveling the mystery of why cancer cells survive and thrive – Science Daily

February 6th, 2017 9:45 am

Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory (JAX) Professor Roel Verhaak reports in Nature Genetics on a newly discovered telomere maintenance mechanism.

The findings open avenues for functional studies that may yield insight into how to steer cancer cells away from immortalizing and back to normal death programming. Moreover, harnessing telomere maintenance mechanisms could be a potential approach to selectively retarding aging. The 2009 Nobel Prize in Physiology or Medicine to Elizabeth Blackburn, Carol Greider and Jack Szostak established the roles of telomeres and telomerase in the aging of cells and organisms.

In most cells, telomeres shorten over time to the point where cell division is no longer possible, leading to cell death. Certain cells, such as stem cells and germ cells, are capable of ongoing division because they contain active telomerase, an enzyme that lengthens telomeres.

It has been long known to researchers that cancer cells reactivate telomerase through telomerase reverse transcriptase (TERT) transcription, but the mechanisms behind this remain elusive.

"These cancer cells are hijacking a mechanism to maintain telomeres, enabling them to continue to divide," Verhaak says.

The researchers scanned 18,430 samples from cancerous and non-neoplastic tissues to determine and compare their telomere lengths and query them for telomerase activity. The analysis, which included samples from 31 different cancer types, showed that telomeres were generally shorter in tumors than in healthy tissues, and longer in soft tissue tumors and brain tumors compared to other cancers.

They found that the majority -- 73 percent -- of cancers expressed TERT (which in turn drives reactivation of telomerase). In addition to the expected mutations and genomic rearrangements driving TERT expression, the researchers discovered an important new mechanism: TERT promoter methylation.

In methylation, clumps of molecules called methyl groups attach to a segment of DNA and can change the activity of that segment without changing its genetic sequence.

Methylation in DNA sequences known as promoters, as the researchers found in most of the cancer samples, typically acts to repress gene transcription, the process of making an RNA copy of a gene sequence. Counterintuitively, Verhaak says, "we found that TERT DNA promoter methylation resulted in TERT expression. We think that because of the DNA methylation, mRNA transcription-repressing proteins are no longer able to bind."

About 22 percent of the tumor cells lacked detectable TERT expression. "There could be a number of reasons for this," says Floris Barthel, a JAX postdoctoral associate and first author of the study. "Maybe not all tumors harbor immortalized cells with a telomere maintenance mechanism, or there are alternative mechanisms at play, or perhaps TERT expression that falls below the detection threshold we used is still sufficient to maintain telomeres." Future studies are needed to elucidate the telomere maintenance mechanisms, or lack thereof, in these tumors, he notes.

Story Source:

Materials provided by Jackson Laboratory. Original written by Joyce Dall'Acqua Peterson. Note: Content may be edited for style and length.

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Blindness (film) – Wikipedia

February 6th, 2017 9:45 am

Blindness is a 2008 Brazilian-Canadian film, an adaptation of the 1995 novel of the same name by Portuguese author Jos Saramago about a society suffering an epidemic of blindness. The film was written by Don McKellar and directed by Fernando Meirelles with Julianne Moore and Mark Ruffalo as the main characters. Saramago originally refused to sell the rights for a film adaptation, but the producers were able to acquire it with the condition that the film would be set in an unnamed and unrecognizable city. Blindness premiered as the opening film at the Cannes Film Festival on May 14, 2008, and the film was released in the United States on October 3, 2008.

A young Japanese professional is struck blind in his car at a crossing and is then approached by a few people, one offers to drive him home and steals his car. The blinded man describes his sudden affliction: an expanse of dazzling white. Upon arriving home and noticing her husband's blindness, the man's wife takes him to a local ophthalmologist who, after testing the man's eyes, can identify nothing wrong and recommends further evaluation at a hospital. Among the doctor's patients are an old man with a black eye-patch, a woman with dark glasses and a young boy. During a dinner with his wife, the doctor discusses the strange case. The woman with dark glasses, revealed to be a call-girl, becomes the third victim of the strange blindness after an appointment with a john in a hotel.

The next day, the doctor goes blind as well. Around the city, more citizens are struck blind, causing widespread panic, and the government organizes a quarantine for the blind in a derelict asylum. When a hazmat crew arrives to pick up the doctor, his wife climbs into the van, lying that she has gone blind in order to accompany him.

In the asylum, the doctor and his wife are first to arrive and both agree they will keep her sight a secret. Several others arrive: the woman with dark glasses, the Japanese man, the car thief, and the young boy. The wife comes across the old man with the eye-patch, who describes the condition of the world outside. The sudden blindness, known as the "white sickness", is now international, with hundreds of cases reported every day. The increasingly totalitarian government resorts to increasingly ruthless measures to try to staunch the epidemic, refusing the sick aid or medicines.

As more blind people are crammed into the prison, overcrowding and lack of outside support causes hygiene and living conditions to degrade. Soon, the walls and floors are caked in filth and human feces. Anxiety over the availability of food undermines the morale and the lack of organization prevents the fair distribution of food. The soldiers who guard the asylum become hostile.

Living conditions degenerate further when an armed clique of men, led by an ex-barman who declares himself the king of ward 3 gains control over the food deliveries. The MRE rations are distributed only in exchange for valuables, and then for the women of the other wards. Faced with starvation, the doctor's wife kills the king. His death initiates a chaotic war between the wards, which culminates with the asylum being burned down and many inmates dying in the fire. The survivors discover that the guards have abandoned their posts and they are free to venture into the city.

Society has fallen as the entire population is blind amid a city devastated and overrun with filth and dead bodies. The doctor's wife leads her husband and others in search of food and shelter. The doctor and his wife arrive in a supermarket filled with stumbling blind people and they find food in a basement storeroom. As she prepares to leave and meet her husband outside, she is attacked by the starving people who smell the food she is carrying. Her husband, now used to his blindness, saves her and they manage to return to their friends.

The doctor and his wife with their new "family" make their way back to the doctor's house, where they establish a permanent home. Just as suddenly as his sight had been lost, the Japanese man recovers his sight. As the friends all celebrate, the doctor's wife stands out on the porch, staring up into a white overcast sky and appears to be going blind until the camera shifts downwards, revealing that she sees the cityscape.

Secondary characters include:

Meirelles chose an international cast. Producer Niv Fichman explained Meirelles' intent: "He was inspired by [Saramago's] great masterwork to create a microcosm of the world. He wanted it cast in a way to represent all of humanity."[10]

The rights to the 1995 novel Blindness were closely guarded by author Jos Saramago.[6] Saramago explained, "I always resisted because it's a violent book about social degradation, rape, and I didn't want it to fall into the wrong hands." Director Fernando Meirelles had wanted to direct a film adaptation in 1997, perceiving it as "an allegory about the fragility of civilization". Saramago originally refused to sell the rights to Meirelles, Whoopi Goldberg, or Gael Garca Bernal.[11] In 1999, producer Niv Fichman and Canadian screenwriter Don McKellar visited Saramago in the Canary Islands; Saramago allowed their visit on condition that they not discuss buying the rights. McKellar explained the changes he intended to make from the novel and what the focus would be, and two days later he and Fichman left Saramago's home with the rights. McKellar believed they had succeeded where others had failed because they properly researched Saramago; he was suspicious of the film industry and had therefore resisted other studios' efforts to obtain the rights through large sums of money alone.[12] Conditions set by Saramago were for the film to be set in a country that would not be recognizable to audiences,[13] and that the canine in the novel, the Dog of Tears, should be a big dog.[14]

Meirelles originally envisioned doing the film in Portuguese similar to the novel's original language, but instead directed the film in English, saying, "If you do it in English you can sell it to the whole world and have a bigger audience."[9] Meirelles set the film in a contemporary large city, seemingly under a totalitarian government, as opposed to the novel that he believed took place in the 1940s (actually, the book is more likely to take place in the 80s or later, as evident by the fact that the characters stumble upon a store with modern appliances like microwave ovens and dishwashers, and referral to AIDS as a feared disease). Meirelles chose to make a contemporary film so audiences could relate to the characters.[14] The director also sought a different allegorical approach. He described the novel as "very allegorical, like a fantasy outside of space, outside the world", and he instead took a naturalistic direction in engaging audiences to make the film less "cold."[15]

Don McKellar said about adapting the story, "None of the characters even have names or a history, which is very untraditional for a Hollywood story. The film, like the novel, directly addresses sight and point of view and asks you to see things from a different perspective." McKellar wrote the script so audiences would see the world through the eyes of the protagonist, the doctor's wife. He sought to have them question the humanity of how she observes but does not act in various situations, including a rape scene. He consulted Saramago about why the wife took so long to act. McKellar noted, "He said she became aware of the responsibility that comes with seeing gradually, first to herself, then to her husband, then to her small family, then her ward, and finally to the world where she has to create a new civilization." The screenwriter wrote out the "actions and circumstances" that would allow the wife to find her responsibility.[5] While the completed script was mostly faithful to the novel, McKellar went through several drafts that were not. One such saw him veer away from the novel by creating names and backstories for all the characters. Another significantly changed the chronology. Only after these abortive attempts did McKellar decide to cut the backstories and focus primarily on the doctor and his wife. He attempted to reconnect with what originally drew him to the novel: what he called its "existential simplicity". The novel defines its characters by little more than their present actions; doing the same for the adaptation became "an interesting exercise" for McKellar.[12]

McKellar attended a summer camp for the blind as part of his research. He wanted to observe how blind people interacted in groups. He discovered that excessive expositional dialogue, usually frowned upon by writers, was essential for the groups. McKellar cut one of the last lines in the novel from his screenplay: "I don't think we did go blind, I think we are blind. Blind but seeing. Blind people who can see, but do not see." McKellar believed viewers would by that point have already grasped the symbolism and didn't want the script to seem heavy-handed. He also toned down the visual cues in his screenplay, such as the "brilliant milky whiteness" of blindness described in the novel. McKellar knew he wanted a stylistically adept director and didn't want to be too prescriptive, preferring only to hint at an approach.[12]

Meirelles chose So Paulo as the primary backdrop for Blindness, though scenes were also filmed in Osasco, Brazil; Guelph, Ontario, Canada; and Montevideo, Uruguay. With all the characters aside from Julianne Moore's character being blind, the cast was trained to simulate blindness. The director also stylized the film to reflect the lack of point of view that the characters would experience. Meirelles said several actors he talked to were intimidated by the concept of playing characters without names: "I offered the film to some actors who said, 'I can't play a character with no name, with no history, with no past. With Gael (Garca Bernal), he said, 'I never think about the past. I just think what my character wants.'"[16]

By September 2006, Fernando Meirelles was attached to Blindness, with the script being adapted by Don McKellar. Blindness, budgeted at $25 million as part of a Brazilian and Canadian co-production, was slated to begin filming in summer 2007 in the towns of So Paulo and Guelph.[17] Filming began in early July in So Paulo and Guelph.[18] Filming also took place in Montevideo, Uruguay.[19] So Paulo served as the primary backdrop for Blindness, being a city mostly unfamiliar to U.S. and European audiences. With its relative obscurity, the director sought So Paulo as the film's generic location. Filming continued through autumn of 2007.[6]

The cast and crew included 700 extras who had to be trained to simulate blindness. Actor Christian Duurvoort from Meirelles' City of God led a series of workshops to coach the cast members. Duurvoort had researched the mannerisms of blind people to understand how they perceive the world and how they make their way through space. Duurvoort not only taught the extras mannerisms, but also to convey the emotional and psychological states of blind people.[6] One technique was reacting to others as a blind person, whose reactions are usually different from those of a sighted person. Meirelles described, "When you're talking to someone, you see a reaction. When you're blind, the response is much flatter. What's the point [in reacting]?"[20]

Meirelles acknowledged the challenge of making a film that would simulate the experience of blindness to the audience. He explained, "When you do a film, everything is related to point of view, to vision. When you have two characters in a dialogue, emotion is expressed by the way people look at each other, through the eyes. Especially in the cut, the edit. You usually cut when someone looks over. Film is all about point of view, and in this film there is none."[20] Similar to the book, blindness in the film serves as a metaphor for human nature's dark side: "prejudice, selfishness, violence and willful indifference."[6]

With only one character's point of view available, Meirelles sought to switch the points-of-view throughout the film, seeing three distinct stylistic sections. The director began with an omniscient vantage point, transited to the intact viewpoint of the doctor's wife, and changed again to the Man with the Black Eye Patch, who connects the quarantined to the outside world with stories. The director concluded the switching with the combination of the perspective of the Doctor's Wife and the narrative of the Man with the Black Eye Patch.[5]

The film also contains visual cues, such as the 1568 painting The Parable of the Blind by Pieter Bruegel the Elder. Allusions to other famous artworks are also made. Meirelles described the intent: "It's about image, the film, and vision, so I thought it makes sense to create, not a history of painting, because it's not, but having different ways of seeing things, from Rembrandt to these very contemporary artists. But it's a very subtle thing."[6]

Prior to public release, Meirelles screened Blindness to test audiences. He described the impact of test screenings: "If you know how to use it, how to ask the right questions, it can be really useful." A test screening of Meirelles' first cut in Toronto resulted in ten percent of the audience, nearly 50 people, walking out of the film early. Meirelles ascribed the problem to a rape scene that takes place partway through the film, and edited the scene to be much shorter in the final cut.[21] Meirelles explained his goal, "When I shot and edited these scenes, I did it in a very technical way, I worried about how to light it and so on, and I lost the sense of their brutality. Some women were really angry with the film, and I thought, 'Wow, maybe I crossed the line.' I went back not to please the audience but so they would stay involved until the end of the story."[9] He also found that a New York City test screening expressed concern about a victim in the film failing to take revenge. Meirelles believed this concern to reflect what Americans have learned to expect in their cinema.[21]

Focus Features acquired the right to handle international sales for Blindness.[22]Path acquired UK and French rights to distribute the film,[23] and Miramax Films won U.S. distribution rights with its $5 million bid.[24]Blindness premiered as the opening film at the 61st Cannes Film Festival on May 14, 2008,[25] where it received a "tepid reception."[26] Straw polls of critics were "unkind" to the film.[27]

Blindness was screened at the Toronto International Film Festival in September 2008 as a Special Presentation.[28] The film also opened at the Atlantic Film Festival on September 11, 2008,[29] and had its North American theatrical release on October 3, 2008.

The film was on some critics' top ten lists of 2008 films but has received very mixed, predominantly negative reviews. With only 66 of 153 (43%) reviews on the film review site Rotten Tomatoes being positive Blindness is considered "rotten". The film has an average rating of 5.2 out of 10.[30]

Screen International's Cannes screen jury which annually polls a panel of international film critics gave the film a 1.3 average out of 4, placing the film on the lower-tier of all the films screened at competition in 2008.[31] Of the film critics from the Screen International Cannes critics jury, Alberto Crespi of the Italian publication L'Unit, Michel Ciment of French film magazine Positif and Dohoon Kim of South Korean film publication Cine21, all gave the film zero points (out of four).[31]

Kirk Honeycutt of The Hollywood Reporter described Blindness as "provocative but predictable cinema", startling but failing to surprise. Honeycutt criticized the film's two viewpoints: Julianne Moore's character, the only one who can see, is slow to act against atrocities, and the behavior of Danny Glover's character comes off as "slightly pompous". Honeycutt explained, "This philosophical coolness is what most undermines the emotional response to Meirelles' film. His fictional calculations are all so precise and a tone of deadly seriousness swamps the grim action."[32] Justin Chang of Variety described the film: "Blindness emerges onscreen both overdressed and undermotivated, scrupulously hitting the novel's beats yet barely approximating, so to speak, its vision." Chang thought that Julianne Moore gave a strong performance but did not feel that the film captured the impact of Saramago's novel.[33]Roger Ebert called Blindness "one of the most unpleasant, not to say unendurable, films I've ever seen."[34]A. O. Scott of The New York Times stated that, although it "is not a great film, ... it is, nonetheless, full of examples of what good filmmaking looks like."[35]

Stephen Garrett of Esquire complimented Meirelles' unconventional style: "Meirelles [honors] the material by using elegant, artful camera compositions, beguiling sound design and deft touches of digital effects to accentuate the authenticity of his cataclysmic landscape." Despite the praise, Garrett wrote that Meirelles' talent at portraying real-life injustice in City of God and The Constant Gardener did not suit him for directing the "heightened reality" of Saramago's social commentary.[36]

Peter Bradshaw of The Guardian called it "an intelligent, tightly constructed, supremely confident adaptation": "Meirelles, along with screenwriter Don McKellar and cinematographer Cesar Charlone, have created an elegant, gripping and visually outstanding film. It responds to the novel's notes of apocalypse and dystopia, and its disclosure of a spiritual desert within the modern city, but also to its persistent qualities of fable, paradox and even whimsy." [37] "Blindness is a drum-tight drama, with superb, hallucinatory, images of urban collapse. It has a real coil of horror at its centre, yet is lightened with gentleness and humour. It reminded me of George A Romero's Night of the Living Dead, and Peter Shaffer's absurdist stage-play Black Comedy. This is bold, masterly, film-making."[38]

The Boston Globe's Wesley Morris raved about the leading actress: "Julianne Moore is a star for these terrible times. She tends to be at her best when the world is at its worst. And things are pretty bad in "Blindness," a perversely enjoyable, occasionally harrowing adaptation of Jos Saramago's 1995 disaster allegory. [...] "Blindness" is a movie whose sense of crisis feels right on time, even if the happy ending feels like a gratuitous emotional bailout. Meirelles ensures that the obviousness of the symbolism (in the global village the blind need guidance!) doesn't negate the story's power, nor the power of Moore's performance. The more dehumanizing things get, the fiercer she becomes."[39]

The film appeared on some critics' top ten lists of the best films of 2008. Bill White of the Seattle Post-Intelligencer named it the 5th best film of 2008,[40] and Marc Savlov of The Austin Chronicle named it the 8th best film of 2008.[40]

The film has been strongly criticized by several organizations representing the blind community. Dr. Marc Maurer, President of the National Federation of the Blind, said: "The National Federation of the Blind condemns and deplores this film, which will do substantial harm to the blind of America and the world."[41] A press release from the American Council of the Blind said "...it is quite obvious why blind people would be outraged over this movie. Blind people do not behave like uncivilized, animalized creatures."[42] The National Federation of the Blind announced plans to picket theaters in at least 21 states, in the largest protest in the organization's 68-year history.[43] Jos Saramago has described his novel as allegorically depicting "a blindness of rationality". He dismissed the protests, stating that "stupidity doesn't choose between the blind and the non-blind."[44]

In a closed section, Jos Saramago watched the movie together with Fernando Meirelles. When the movie ended, Saramago was in tears. He turned to Fernando Meirelles and said: "Fernando, I am so happy to have seen this movie as I was the day I finished the book." [45]

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Five innovations harness new technologies for people with visual impairment, blindness – Science Daily

February 6th, 2017 9:45 am

During Low Vision Awareness Month, the National Eye Institute (NEI), part of the National Institutes of Health, is highlighting new technologies and tools in the works to help the 4.1 million Americans living with low vision or blindness. The innovations aim to help people with vision loss more easily accomplish daily tasks, from navigating office buildings to crossing a street. Many of the innovations take advantage of computer vision, a technology that enables computers to recognize and interpret the complex assortment of images, objects and behaviors in the surrounding environment.

Low vision means that even with glasses, contact lenses, medicine, or surgery, people find everyday tasks difficult to do. It can affect many aspects of life, from walking in crowded places to reading or preparing a meal, explained Cheri Wiggs, Ph.D., program director for low vision and blindness rehabilitation at the NEI. The tools needed to stay engaged in everyday activities vary based on the degree and type of vision loss. For example, glaucoma causes loss of peripheral vision, which can make walking or driving difficult. By contrast, age-related macular degeneration affects central vision, creating difficulty with tasks such as reading, she said.

Here's a look at a few NEI-funded technologies under development that aim to lessen the impact of low vision and blindness.

Co-robotic cane

Navigating indoors can be especially challenging for people with low vision or blindness. While existing GPS-based assistive devices can guide someone to a general location such as a building, GPS isn't much help in finding specific rooms, said Cang Ye, Ph.D., of the University of Arkansas at Little Rock. Ye has developed a co-robotic cane that provides feedback on a user's surrounding environment.

Ye's prototype cane has a computerized 3-D camera to "see" on behalf of the user. It also has a motorized roller tip that can propel the cane toward a desired location, allowing the user to follow the cane's direction. Along the way, the user can speak into a microphone and a speech recognition system interprets verbal commands and guides the user via a wireless earpiece. The cane's credit card-sized computer stores pre-loaded floor plans. However, Ye envisions being able to download floor plans via Wi-Fi upon entering a building. The computer analyzes 3-D information in real time and alerts the user of hallways and stairs. The cane gauges a person's location in the building by measuring the camera's movement using a computer vision method. That method extracts details from a current image captured by the camera and matches them with those from the previous image, thus determining the user's location by comparing the progressively changing views, all relative to a starting point. In addition to receiving NEI support, Ye recently was awarded a grant from the NIH's Coulter College Commercializing Innovation Program to explore commercialization of the robotic cane.

Robotic glove finds door handles, small objects

In the process of developing the co-robotic cane, Ye realized that closed doorways pose yet another challenge for people with low vision and blindness. "Finding the door knob or handle and getting the door open slows you way down," he said. To help someone with low vision locate and grasp small objects more quickly, he designed a fingerless glove device.

On the back surface is a camera and a speech recognition system, enabling the user to give the glove voice commands such as "door handle," "mug," "bowl," or "bottle of water." The glove guides the user's hand via tactile prompts to the desired object. "Guiding the person's hand left or right is easy," Ye said. "An actuator on the thumb's surface takes care of that in a very intuitive and natural way." Prompting a user to move his or her hand forward and backward, and getting a feel for how to grasp an object, is more challenging.

Ye's colleague Yantao Shen, Ph.D., University of Nevada, Reno, developed a novel hybrid tactile system that comprises an array of cylindrical pins that send either a mechanical or electrical stimulus. The electric stimulus provides an electrotactile sensation, meaning that it excites the nerves on the skin of the hand to simulate a sense of touch. Picture four cylindrical pins in alignment down the length of your index finger. One by one, starting with the pin closest to your finger tip, the pins pulse in a pattern indicating that the hand should move backward.

The reverse pattern indicates the need for forward motion. Meanwhile, a larger electrotactile system on the palm uses a series of cylindrical pins to create a 3-D representation of the object's shape. For example, if your hand is approaching the handle of a mug, you would sense the handle's shape in your palm so that you could adjust the position of your hand accordingly. As your hand moves toward the mug handle, any slight shifts in angle are noted by the camera and the tactile sensation on your palm reflects such changes.

Smartphone crosswalk app

Street crossings can be especially dangerous for people with low vision. James Coughlan, Ph.D., and his colleagues at the Smith-Kettlewell Eye Research Institute have developed a smartphone app that gives auditory prompts to help users identify the safest crossing location and stay within the crosswalk.

The app harnesses three technologies and triangulates them. A global positioning system (GPS) is used to pinpoint the intersection where a user is standing. Computer vision is then used to scan the area for crosswalks and walk lights. That information is integrated with a geographic information system (GIS) database containing a crowdsourced, detailed inventory about an intersection's quirks, such as the presence of road construction or uneven pavement. The three technologies compensate for each other's weaknesses. For example, while computer vision may lack the depth perception needed to detect a median in the center of the road, such local knowledge would be included in the GIS template. And while GPS can adequately localize the user to an intersection, it cannot identify on which corner a user is standing. Computer vision determines the corner, as well as where the user is in relation to the crosswalk, the status of the walk lights and traffic lights, and the presence of vehicles.

CamIO system helps explore objects in a natural way

Imagine a system that enables visually impaired biology students to explore a 3-D anatomical model of a heart by touching an area and hearing "aortic arch" in response. The same system could also be used to get an auditory readout of the display on a device such as a glucose monitor. The prototype system, designed with a low-cost camera connected to a laptop computer, can make physical objects -- from 2-D maps to digital displays on microwaves -- fully accessible to users with low vision or blindness.

The CamIO (short for camera input-output), also under development by Coughlan, provides real-time audio feedback as the user explores an object in a natural way, turning it around and touching it. Holding a finger stationary on 3-D or 2-D objects, signals the system to provide an audible label of the location in question or an enhanced image on a laptop screen. CamIO was conceived by Joshua Miele, Ph.D, a blind scientist at Smith-Kettlewell who develops and evaluates novel sound/touch interfaces to help people with vision loss. Coughlan plans to develop a smartphone app version of CamIO. In the meantime, software for the laptop version will be available for free download. To watch a demonstration of the CamIO system, visit http://bit.ly/2CamIO.

High-powered prisms, periscopes for severe tunnel vision

People with retinitis pigmentosa and glaucoma can lose most of their peripheral vision, making it challenging to walk in crowded places like airports or malls. People with severe peripheral field vision loss can have a residual central island of vision that's as little as 1 to 2 percent of their full visual field. Eli Peli, O.D., of Schepens Eye Research Institute, Boston, has developed lenses constructed of many adjacent one-millimeter wide prisms that expand the visual field while preserving central vision. Peli designed a high-powered prism, called a multiplexing prism that expands one's field of view by about 30 degrees. "That's an improvement, but it's not good enough," explained Peli.

In a study, he and his colleagues mathematically modeled people walking in crowded places and found that the risk of collision is highest when other pedestrians are approaching from a 45-degree angle. To reach that degree of peripheral vision, he and his colleagues are employing a periscope-like concept. Periscopes, such as those used to see the ocean surface from a submarine, rely on a pair of parallel mirrors that shift an image, providing a view that would otherwise be out of sight. Applying a similar concept, but with non-parallel mirrors, Peli and colleagues have developed a prototype that achieves a 45-degree visual field. Their next step is to work with optical labs to manufacture a cosmetically acceptable prototype that can be mounted into a pair of glasses. "It would be ideal if we could design magnetic clip-ons spectacles that could be easily mounted and removed," he said.

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Five innovations harness new technologies for people with visual impairment, blindness - Science Daily

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Arizona woman cured of blindness spreads fame of obscure Lebanese saint – Fox News

February 6th, 2017 9:45 am

The story of a Latina who regained her sight thanks to what is believed to be a miracle performed by St. Charbel, has awakened interest in the relics of this Lebanese saint being kept at a church in Phoenix, Arizona.

Dafne Gutierrez is convinced she was able to see again after she visited the relics at St. Joseph Maronite Catholic Church a year ago. So many people continue to visit the chapel since that it was decided to create a sanctuary in his honor.

The Lebanese pastor of the church, Fr. Wissam Akiki, told EFE that the construction of the sanctuary has already begun and will be shaped like a half-moon, with a large statue of the saint standing at the center.

Gutierrez, whose blindness was healed on Jan. 18, 2016, insists that what happened to her was truly a miracle.

"The doctors can't explain it. At first they thought I was imagining things because I so longed to see, but when they examined me no damage to the optic nerve was to be found," she said. "They were surprised, because according to their diagnosis, I was never going to see again, not even with a cornea transplant," she said.

Cristofer Pereyra, director of the Hispanic Office of the Phoenix Diocese, said that Bishop Thomas Olmsted himself spoke with the doctors and checked very carefully the womans case.

The bishop went to make sure there was no scientific explanation for the miraculous recovery of Dafne's sight, Pereyra said.

Fr. Akiki said that thousands of people now visit the saint's relics for their miraculous powers.

"Dafne came to confess to me, and I told her to pray and have faith. Then I made the sign of the cross on her forehead and her eyes. And then St. Charbel performed the miracle that would benefit her three children," the priest said.

The relics of St. Charbel, whose real name was Youssef Antoun Makhlouf, visited Phoenix between Jan. 15 and Jan. 17, 2016; they have toured various parishes around the country since October 2015.

In view of the great devotion of the faithful to thissaint, it was decided to leave a fragment of his hand in Phoenix,a city with a large Lebanese community.

Gutierrez, who had lived with the Arnold Chiari malformation since age 13, went blind in both eyes several years ago.

"I remember hearing on the news about a saint who did miracles, but I'd already been to so many churches I wasn't very excited about it. It was my sister-in-law who convinced me," she said.

St. Charbel died at age 70 at a Maronite monastery in Lebanon on Christmas Eve, 1898. His body lies in a tomb and was said to remain undecomposed for the greater part of a century.

The saint, who has a long history of healing the sick and disabled, even after his death, was beatified on Dec. 5, 1965, and canonized on Oct. 9, 1977, by Pope Paul VI, making him the first Lebanese saint.

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Arizona woman cured of blindness spreads fame of obscure Lebanese saint - Fox News

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Portsmouth Daily Times | Prevent Blindness declares February as … – Portsmouth Daily Times

February 6th, 2017 9:45 am

Today, more than 2 million Americans ages 50 and over have age-related macular degeneration (AMD), according to the Prevent Blindness report, Future of Vision: Forecasting the Prevalence and Costs of Vision Problems. This includes 88,546 in Ohio alone. And, the increase of the population aged 80 and older will lead to rapid growth in the AMD population over the next 20 years, reaching 3.4 million in 2032 and 4.4 million by 2050.

The Ohio Affiliate of Prevent Blindness has declared February as Age-related Macular Degeneration/Low Vision Awareness Month. AMD is a leading cause of vision loss for Americans age 50 and older. It affects central vision, where sharpest vision occurs. Almost 3 million Americans have low vision, according to the National Eye Institute.

According to the recent National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division (NASEM) consensus study, Making Eye Health a Population Health Imperative: Vision for Tomorrow, increasing age, white race, and female gender are associated with a higher risk of AMD. The report also found that a number of environmental, behavioral, genetic, and other physical conditions have been associated with the risk of AMD, including smoking, obesity and genetics.

There may be no symptoms until the disease progresses or affects both eyes, which is why regular eye exams are important. Vision changes due to AMD may include:

Prevent Blindness offers educational materials at no cost through its dedicated web pages and its toll-free number. Resources include:

Prevent Blindness AMD Learning Center- The AMD Learning Center, found at preventblindness.org/amd, provides a variety of educational tools including AMD risk factors, treatment options, an Adult Vision Risk Assessment tool, fact sheets and more.

Living Well with Low Vision- This growing online resource, lowvision.preventblindness.org, offers information ranging from an extensive list of searchable, local low vision resource directories, to an informative blog with news for people living with age-related eye disease and significant visual impairment, and their caregivers, authored by patient advocate and low vision educator Dan Roberts, M.M.E.

By detecting AMD and treating it early, vision loss can be significantly lessened, said Sherry Williams, President & CEO of Prevent Blindness, Ohio Affiliate. We urge everyone to make an appointment for a dilated eye exam today.

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Portsmouth Daily Times | Prevent Blindness declares February as ... - Portsmouth Daily Times

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Government turns a Nelson’s Eye to increasing cases of blindness reported in Telangana – The New Indian Express

February 6th, 2017 9:45 am

HYDERABAD: Telangana state has 2 per cent rate of prevalence of blindness, reveals the District Level Household and Facility Survey (DLHS-4) data. This is the highest in the country.

The DLHS data clearly indicates that the state government needs to ramp up its infrastructure for controlling the increasing rate of blindness in the state.

In India, blindness is caused mainly due to two reasons: cataract and refractive errors like near and far sightedness. And both of them can be avoided if adequate healthcare is available.

The Central government, as far back as in 1976, had launched the National Programme for Control of Blindness (NPCB) for preventing occurrence of blindness.

However, thanks to the poor financial and infrastructural support from the state and following governments at the Centre, the National Programme for Control of Blindness has not been implemented efficiently and widely in the state of Telangana ever since its formulation.

State of affairs

Telangana has around 150 ophthalmic assistants today, located only in the Cluster Health Centres instead of the Primary Health Centres (PHCs). These ophthalmic assistants play a key role in implementation of the School Eye Screening programme of NPCB.

As part of the SES, the assistants prescribe glasses to students of government school aged between 10 and 14 and diagnosed with refractive error. These glasses are provided for free under the programme.

Statistically speaking, there are around 10 lakh children in the age group of 10-14 studying in government schools in the state. This means, each ophthalmic assistant has to keep track of at least 7,000 children every year. This makes it quite clear why, as per NPCB data, the state government could not achieve the target of providing glasses to 52,930 school children in the years 2014-16. They could provide glasses to around 46,000 school children.

Meanwhile, other states including Gujarat and Madhya Pradesh, for the same period, exceeded their targets providing glasses to over 2.3 lakh and 1.5 lakh children respectively.

Other issues

Lack of adequate infrastructure and expertise at district level to undertake cataract surgeries is another issue.

While Gujarat and MP conducted 16 lakh and 10 lakh cataract surgeries in 2014-16 respectively, only 10 lakh surgeries were conducted in Telangana.

NPCB officials pointed out that there has also been a delay in allotment of money by the Centre and state. The central government recently released around Rs 4 crore to NPCB in the state for the year 2016-17 and the state is yet to release its share.

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Government turns a Nelson's Eye to increasing cases of blindness reported in Telangana - The New Indian Express

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