StemCell Therapy

PHILADELPHIA, Sept. 10, 2022 (GLOBE NEWSWIRE) -- Cabaletta Bio, Inc. (Nasdaq: CABA), a clinical-stage biotechnology company focused on the discovery and development of targeted cell therapies for patients with autoimmune diseases, today presented updated clinical and translational data through 6 months of follow-up in cohorts A1 through A4 as well as 28-day safety data and DSG3-CAART persistence data through day 29 for cohorts A1 through A5 from the DesCAARTes™ trial at the 31st European Academy of Dermatology and Venereology (EADV) Congress, which is being held in Milan, Italy from September 7-10, 2022.

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Cabaletta Bio Presents New Interim Data from the DesCAARTes™ Phase 1 Trial at the 31st EADV Congress

-Sotigalimab in combination with neoadjuvant chemoradiation induced higher pathologic complete response rates, an important predictor of survival, in patients with both adenocarcinoma and squamous cell carcinoma- -Sotigalimab in combination with neoadjuvant chemoradiation induced higher pathologic complete response rates, an important predictor of survival, in patients with both adenocarcinoma and squamous cell carcinoma-

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Apexigen Presents New Data from a Phase 2 Trial Evaluating its CD40 Antibody, Sotigalimab, in Combination with Neoadjuvant Chemoradiation in Patients...

ImCheck Therapeutics today presented promising updated safety and patient response data from the completed dose escalation combination cohort of its ongoing EVICTION clinical trial during an oral session at the European Society for Medical Oncology (ESMO) Congress currently being held in Paris, France. EVICTION is an open-label Phase I/IIa study evaluating ImCheck’s lead antibody ICT01 as a monotherapy in both solid tumor and hematological cancers, and in combination with pembrolizumab in solid tumors.

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Presents Positive Safety and Efficacy Data from the Completed Phase 1 Dose Escalation Cohort of ICT01 plus Pembrolizumab in the EVICTION Trial at...

– Nirogacestat Treatment Resulted in Rapid, Sustained and Statistically Significant Improvements in Primary and All Key Secondary Efficacy Endpoints –

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SpringWorks Therapeutics Announces Data from Phase 3 DeFi Trial Evaluating Nirogacestat in Adult Patients with Progressing Desmoid Tumors at the...

88% overall response rate (15 out of 17) from interim data of pan-FGFR treatment (FGFRi)-naïve FGFR2-fusion cholangiocarcinoma (CCA) patients treated at the pivotal dose

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Late Breaking Data Presented at ESMO Congress 2022 Demonstrate Potential of RLY-4008 to Transform Treatment Options for Cholangiocarcinoma Patients...

TORONTO, Sept. 11, 2022 (GLOBE NEWSWIRE) -- Axiom Real-Time Metrics ("Axiom"), the premier provider of unified eClinical solutions and services focused on small-to-medium life science organizations, will be exhibiting at SCDM 2022 Annual Conference, September 11-13 in San Antonio, TX.

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Axiom Exhibiting at SCDM 2022 Annual Conference

PHILADELPHIA, Sept. 12, 2022 (GLOBE NEWSWIRE) -- AnPac Bio-Medical Science Co., Ltd. (“AnPac Bio,” the “Company” or “we”) (ANPC), a biotechnology company with operations in the United States and China focused on early cancer screening and detection, announced that on September 9, 2022, it received a Staff determination letter (the “Letter”) from the Listing Qualifications Department of The Nasdaq Stock Market LLC (“Nasdaq”) notifying the Company of the Staff’s determination to delist the Company’s securities from The Nasdaq Capital Market due to the Company’s failure to regain compliance with the $1 per share bid price requirement of Listed Securities required for continued listing as set forth in Listing Rule 5450(a)(1) (the “$1 Bid Rule”). The Letter states that, unless the Company requests an appeal of the Letter, trading of the Company’s American Depositary Shares will be suspended at the opening of business on September 20, 2022, and a Form 25-NSE will be filed with the Securities and Exchange Commission (the “SEC”) to remove the Company’s securities from listing and registration on the Nasdaq Stock Market. The Company has the option to appeal the delisting determination and intends to do so.

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AnPac Bio-Medical Sciences Announces Receipt of Staff Delisting Determination from Nasdaq; Intends to Appeal

Prison facilities in Ionia and Adrian are shrinking this fall in the wake of a plummeting prison population and a crippling shortage of workers.

The consolidations wont result in layoffs, however. There are enough openings in prisons in each of the Michigan communities to absorb the employees of the mothballed facilities.

But these closures could just be a short-term solution to Michigans chronic corrections officer shortage.

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At the end of the day, if [employee] attrition isnt addressed by the summer of 2023, were going to be in the same boat, said Byron Osborn, president of the Michigan Corrections Organization.

The Michigan Reformatory in Ionia will close in November, with the male prisoners now housed there moving to other facilities, according to a Michigan Department of Corrections announcement released Wednesday. In Adrian, the south side of the Gus Harrison Correctional Facility will be shuttered by November.

The consolidations will help address two problems: prison units that are underutilized because of a dropping prison population and a shortage of employees to operate all the current facilities. Currently, some of the states prison employees work mandatory overtime weekly. According to a Bridge Michigan story in July, some employees routinely worked 80 hours a week.

While these announcements are normally and understandably difficult on staff, in this instance, we know it may be welcome news to many, MDOC Director Heidi Washington said in a statement Wednesday. This will provide much-needed relief to our officers, nurses and other employees who have worked significant overtime shifts over the past few years.

With Wednesdays announcement, the states prison system now has 33 closed prison units.

Michigans prison population peaked with over 51,000 inmates in 2007. Today, the prison population is about 32,000, the lowest level in 30 years, according to the MDOC statement.

The states aging population has contributed to the decline as has a drop in the recidivism rate in the past two decades, from 45 percent of ex-cons returning to prison to about 24 percent.

MDOC spokesperson Chris Gautz said the new consolidations are unlike any other closures in recent memory because its likely that any displaced worker who wants to stay with the prison system will be able to continue to work in the same community at a neighboring facility. There are more job openings at Ionias three remaining prisons than workers at the soon-to-be-closed Michigan Reformatory.

Once those workers transfer to other facilities, mandatory overtime will decrease significantly, Gautz said. The Ionia state prison facilities each have an employee vacancy rate of about 25 percent.

This is really good news for Ionia (prison workers) who have been working a lot of mandated overtime, Gautz said.

Osborn, the union president and a corrections officer for 28 years, said that while his members in Ionia and Adrian will be relieved to have less mandatory overtime, other state prison facilities also face crippling staff shortages.

Jackson is worse than Ionia, Osborn told Bridge Michigan. We have six facilities in the U.P. that are all short (of prison officers). Were short everywhere.

Osborn praised MDOC director Washington for beefed-up recruitment efforts for new employees, but officers are quitting faster than they can be replaced.

People leave because they dont want to work double shifts and get beat up by prisoners, Osborn said. Its not a pleasant place to work.

He encouraged the Legislature to consider increased pay and benefits for prison employees to attract and retain officers.

This is going to be a six-month Band-Aid before our normal attrition rate eats up the gains, Osborn said.

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With fewer inmates (and officers), Michigan closes another prison - Bridge Michigan

Crazy Bulk Testol 140 is a legal alternative to RAD 140 (testolone). It was created to offer bodybuilders and athletes the same muscle building benefits of the SARM with the side effects and the legal complications. This Testol-140 review covers all aspects of the product; what is it, what it does, what is in it and also provides some real Testol 140 reviews from customers that have used it.

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6 Reasons to Use Testol 140?

Increases lean muscle mass naturally and safely

Helps muscle definition

Fires-up metabolism to burn excess fat

Can mimic rapid anabolic gains

Boosts natural testosterone levels

Legal to buy and use

At its most basic, Testol 140 is a testosterone booster. You may have guessed that by the name.

However, this is anything but a run-of-the-mill testosterone-boosting supplement. It was developed to provide bodybuilders with a safe alternative to a popular bodybuilding drug called Testolone, which is also often referred to by its original development code, RAD 140.

RAD 140 has much in common with anabolic steroids but there are differences. RAD 140 is a selective androgen receptor modulator (SARM), not a steroid.

Testol 140 is neither a steroid nor a SARM, it's an all-natural supplement designed to increase testosterone levels sufficiently to deliver SARM and steroid-like benefits. It's also designed to be 100% safe. In case you haven't heard, SARMs and steroids are not.

In this Testol 140 review, we are going to put this legal and safe alternative underneath the microscope and see how good it really is. We are going to take a look at how it works, the way it compares to steroids and SARMs, and the abilities of the ingredients the supplement contains.

As and when necessary, we will reference scientific studies and research papers, all of which are available online. We will provide links to these at the bottom of the page.

However, before we begin evaluating the supplement and its ingredients, we will provide a little information about testosterone, steroids, SARMs, and the value all three have as muscle growth enhancers, along with the benefits they provide in other areas.

Testol 140 can also be used in a SARM bulking stack to improve results. The bulking stack includes other Crazy Bulk legal SARMs.

View SARM Bulking Stack Offers

"Great formula for helping to maintain lean muscle mass. Clean and don't give stomach cramps. Helped me cut fat and increase my muscle development after about a month on it."

"Im 37 and my testosterone levels were low and I couldn't gain muscle mass. I was tired all the time. Testol-140 saved my life!! I have more energy and stamina. I can see more muscle definition."

"Felt incredible while taking Testol-140. My mood was great and my energy lasted a lot longer. My workout routine lasts longer and I feel so much stronger."

"I'm a hard gainer, I find it difficult to put on muscle. Testol 140 helped me increase muscle mass and boosted my physical performance. I have so much more energy and staying power now."

"I am a powerlifter, taking Testol 140 made me blast through my plateau, I am lifting more than ever now"

"Been taking Testol-140 for about 4 months, I used a bulking stack with LGD 4033 and Ostarine MK 2866. I have tons more muscle power and muscular mass. I also use it in combo with some other supplements in a cutting stack, it really helps decrease body fat and fat reduction."

Check Verified Testol140 Reviews

Manufactured by Crazy Bulk - a leading supplement company that specializes in legal steroids, SARM and bodybuilding products.

Crazy Bulk has been in existence for around a decade. In this time Crazy Bulk has pretty much revolutionized the bodybuilding and muscle supplement industry. Nowadays you do not need to compromise your health for massive muscle gains. You can build lean muscle mass with natural ingredients just as quickly without subjecting your body to the harmful effects of anabolic steroids.

Testosterone is a steroid produced in the body. It's also the male sex hormone.

In its role as a steroid, testosterone aids muscle growth and repair, improves bone density, aids fat burning, provides invigoration, and even assists clear thinking. It's a busy bee.

In its role as an androgen hormone, testosterone is a key player in the many changes that occur during puberty and adolescence. Changes that transform little boys into men.

Men don't have a monopoly on testosterone. Women produce it in their bodies too but to a much lesser extent. The androgen hormone estrogen is the driving force in the female body but we don't need to delve too deeply into the various differences between the sexes here.

When men are low in testosterone, it can lead to many undesirable issues including reductions in bone and muscle mass. It can also cause loss of libido and interfere with a man's ability to have sex.

At the other end of the scale, higher testosterone levels can help men improve their overall body composition by fueling improvements in muscle mass and reductions in body fat.

Other potential benefits include increased energy, greater stamina, heightened sex drive, and improvements in sexual performance.

Most of these benefits are due to testosterone's ability to bind with androgen receptors.

Androgen receptors allow testosterone to react with muscle tissue. When they bind with the hormone it enhances protein synthesis and muscle gains.

Steroids and SARMs are chemical impostors that share testosterone's ability to bind with androgen receptors and improve muscle growth.

Selective androgen receptor modulators are reputed to be safer than steroids because they only bind with the androgen receptors in muscle and bone. However, all SARMs, including RAD 140, can present dangerous side effects. They are experimental drugs and should never be seen as safe.

Testolone is an investigative SARM created by Radius Health. The company name is the source of the "RAD" in the drug development code.

Like other true SARMs, it takes over the role of testosterone. This causes your body to produce less. The result of this is you cannot just stop using RAD 140. You need to follow your cycle with a post-cycle therapy (PCT) until your testosterone production comes back online.

However, animal-based research suggests the RAD 140 SARM may deliver notable improvements in muscle size. For this reason, it has become a very popular bodybuilding SARM.

Some bodybuilders use RAD 140 on its own. Far more cycle it alongside other SARMs and steroids, but it's not approved for human use. It remains an experimental drug. There may be significant dangers involved.

In 2020, Hepatology Communications published two cases of bodybuilders who suffered liver damage due to using this SARM. [1]

Testol 140 is the Crazy Bulk safe alternative to Testolone RAD 140. You may have heard of Crazy Bulk because the company gets a lot of respect for its range of safe and legal alternative steroid substitutes.

Instead of pushing your natural testosterone out of the way and replacing it with a synthetic alternative, Testol 140 helps your body increase testosterone production.

By doing this, the supplement makes extra testosterone available to bind with the androgen receptors in your muscles. This, of course, results in greater enhancements in protein synthesis - and SARM-like muscle growth.

Crazy Bulk tells its customers to expect the following results:

Safe increases in muscle mass and bulk

Greater exposure of your muscle mass

Fat loss

A natural testosterone boost

In this case, Crazy Bulk is selling its supplement short.

The key thing to remember here is that Testol 140 is a testosterone booster. That means, if you use it, you can expect all the benefits associated with higher testosterone production.

This may include improvements in libido and sexual performance, and improvements in cognitive function. As with the SARM it replaces, Testol 140 should also improve bone mineral density.

It can be used in a bulking stack and is accepted to be among the best bulking SARMs in existence.

Each (4-capsule) dose of Testol 140 provides nine ingredients in the following quantities:

Zinc (10 mg)

Magnesium (375 mg)

Vitamin B6 (1.4 mg)

Vitamin D3 (5 mcg)

Conjugated linoleic acid (1200 mg)

Fenugreek 4:1 (400 mg)

KSM-66 Ashwagandha extract 12:1 (300 mg)

Pomegranate whole fruit powder (300 mg)

Senactive (50 mg)

Please note Fenugreek and KSM-66 are provided here in concentrated form.

Fenugreek is concentrated to four times normal strength. That means the 400 mg the supplement contains is the equivalent of 1.6 grams of standard-strength fenugreek extract.

KSM-66 is 12 times normal strength so don't accept the 300 mg inclusion rate at face value. It's the equivalent of 3.6 grams of KSM-66 provided at normal strength.

Using concentrates like these allows Crazy Bulk to keep the size of the pills reasonably small.

Here is a deeper dive into the ingredients included in the Testol140 formula and what they actually do.

Zinc has a longstanding reputation as a testosterone booster. Data collected via numerous clinical trials confirm the important role this mineral plays in testosterone production.

Data from one study is particularly interesting. Some of the participants were young men in good health. The rest of the participants were elderly men who were marginally zinc deficient.

The scientists reduced zinc intake among the younger men, causing them to become zinc deficient. Although the induced deficiency was only slight, after 20 weeks, the young men were showing a significant drop in testosterone.

Meanwhile, the scientists gave the elderly men daily doses of zinc via supplements. After six months, the men's serum testosterone levels had almost doubled. [2]

Magnesium is another mineral that can boost testosterone. However, although zinc is present in most good testosterone-boosting supplements, magnesium is not - this is where Testol 140 has an advantage over competing SARM alternatives.

Magnesium may not be a popular choice with supplement manufacturers but it's great to see Crazy Bulk using it here. It's a perfect choice for a supplement that's aimed at men who like to lift weights. The results of one clinical trial, in particular, prove that this is so.

The researchers in charge of the study in question set out to explore the relationship between magnesium, exercise, and testosterone levels.

Some of the research subjects were men with sedentary lifestyles. The rest were taekwondo athletes who were training for 90-120 minutes each day.

Data from the study shows the magnesium supplements increased free and total testosterone levels in the men of both groups.

However, the increase was more notable among the athletic men. [3]

Vitamin B6 aids energy metabolism by helping the body extract energy from food. If you have ever noticed its presence in energy drinks and this has given you pause for thought, now you know why it is there.

You take Testol 140 before training so, it goes without saying, the vitamin B6 it provides may help empower your workout. However, vitamin B6 has value in multiple areas some of which may be particularly beneficial to bodybuilders and other athletes who like to train.

Research suggests vitamin B6 may play a role in protein synthesis. Results from one study that supports this theory suggest the vitamin may also increase testosterone uptake and sensitivity in the tissues. [4]

More recently, scientists have discovered vitamin B6 appears to have a favorable effect on the muscle stem cells that are a driving force in muscle regeneration. [5]

There are two forms of vitamin D available to supplement manufacturers - vitamin D2 and vitamin D3.

One form is plant-based. The other comes from animals. Testol 140 provides vitamin D3 (cholecalciferol). That's the animal-based form. It's generally produced from sheep wool. However, regardless of its source, its presence in the formulation will make Testol 140 an unsatisfactory option for vegans and vegetarians.

Vitamin D has a longstanding association with improvements in testosterone. It also aids calcium absorption, helping to provide strong bones. In addition to doing these things, vitamin D assists good health in many other ways including supporting healthy immune function.

Even if you disregard its reputation as a testosterone booster, vitamin D is still a worthy inclusion for a formulation like this one. Research suggests a link between muscle strength and function. [6]

Conjugated linoleic acid (CLA) is a fatty acid that's naturally occurring in meat and dairy products. Grass-fed beef is a particularly good source.

However, the CLA in supplements is plant-based. It's refined from safflower oil.

CLA does not boost testosterone. Nevertheless, it's a good addition to the Testol 140 formulation.

Although some testosterone boosters are designed for middle-aged men suffering from low testosterone, Testol 140 does not hang with that crowd. It's made for men who want to gain more muscle and have a superior physique.

Research shows CLA enhances fat-burning capability while also offering modest improvements in muscle mass. [7]

As a companion ingredient to the main testosterone boosters in the formulation, CLA is first-rate and Testol 140 provides a very generous dose.

Read more:
Testol 140 Review, Real Testol-140 Reviews Before and After Results - Dailyuw

It was the sort of bold, climate-focused initiative that California has developed a reputation for an effective ban on the sale of new gasoline-powered cars by 2035.

But last months historic vote by the California Air Resources Board follows a number of sweeping state environmental actions that have met with varying degrees of success.

Now, as officials seek to fundamentally change Californias automotive culture thereby reducing its largest source of planet-warming carbon emissions and air pollution experts say those past initiatives may shed light on whether Californias nation-leading auto plan can work.

In Los Angeles, the dense smog that once smothered the city is regarded today as folklore. At its worst, between the 1950s and 1980s, the caustic haze was so thick that people could see only as far as a city block. It irritated peoples throats and lungs, and gave them bloodshot eyes. Back then, there were more than 200 days with unhealthy air annually, according to the Air Resources Board.

Since that time, there has been tremendous progress toward reducing smog and air pollution, much of it due to cleaner cars. The amount of smog-forming nitrogen oxides has been slashed by more than 50% in the last two decades, substantially improving public health.

But Californias progress in fighting air pollution has stagnated in recent decades, and the state is still home to the worst air pollution in the nation. The South Coast air basin Los Angeles, Orange, Riverside and part of San Bernardino counties has yet to meet any federal health standards for ozone levels, including the oldest measure enacted in 1979.

If youre looking back 70 years, weve done a wonderful job, said Joe Lyou, president of the Coalition for Clean Air. If youre looking back over the last decade or two, not so good. And if youre looking at the legal standards that demand that we provide healthy air for people to breathe, were not doing well at all.

Global warming has further exacerbated the problem by fueling wildfires and conditions that are more conducive to smog formation.

Hazardous air pollution days are off the charts because of growth in climate-driven wildfires, said Will Barrett, national senior director for clean air advocacy for the American Lung Assn. We also know ozone is formed when tailpipe emissions and other emissions mix in the atmosphere on hot, sunny days. We are seeing more heat, more extreme weather events, creating better conditions for the formation of ozone and threatening health on the ground. These are dual crises. They stem from the same sources transportation sources.

But it was the states ability to tackle and solve a major smog crisis that gives some experts hope that it can also transform transportation.

The Air Resources Boards greatest claim to fame before the climate era was its role in creating and enforcing the adoption of catalytic converters and other technologies to reduce the emissions of smog-forming pollution, which was choking the major metropolitan centers in both the Bay Area and on the South Coast, said Danny Cullenward, policy director at the nonprofit climate research organization CarbonPlan. So the Air Resources Board as an institution really sort of cut its teeth, and was extraordinarily successful in earlier decades, in tackling just a massive problem that involved complicated technologies, powerful industries and issues that affected peoples everyday lives.

One of Californias landmark climate programs, cap-and-trade was initially launched in 2006 with the aim of reducing the states greenhouse gas emissions to 1990 levels by 2020. It exceeded expectations, and in fact reached the target four years ahead of time.

In 2017, the program was reauthorized with a much more ambitious goal: Slashing greenhouse gas emissions to 40% of 1990 levels by 2030. To get there, the program uses a system of pollution credits that essentially lets large carbon emitters buy and sell unused credits with the aim of keeping everyone at or below a certain total.

Experts say it only sort of worked. While the program has remained a key element of Californias climate strategy, emissions were down about 11% in 2020 far from the 40% goal. Whats more, that number likely accounts for emissions reductions tied to the start of the COVID-19 pandemic.

The evidence is pretty clear that were not on track for that target, and the reliance on this program is a big part of the reason why were not on track, Cullenward said.

Air Resources Board spokesman David Clegern said via email that the state has the policies in place to meet its target, but getting there means concerted action needs to happen on implementing policies to reduce transportation, short-lived climate pollutants, electricity and other emissions to achieve 2030.

The fact that the state achieved its 2020 goal four years early and the success of programs such as the Low Carbon Fuel Standard and the addition of new programs means the role of cap-and-trade may be smaller in the future, but that will be evaluated after release of the 2020 Scoping Plan later this year, he said. The scoping plan is a roadmap for achieving carbon neutrality in the state, and is updated every five years.

Cullenward noted that the cap-and-trade program has some clear parallels to the advanced clean cars rule, including its plan to provide credits to auto manufacturers who sell more electric vehicles than theyre required to. However, there are also some key differences that made him more optimistic about the gas car bans prospects of success.

For one, he said, the Air Resources Board has historically had more strength as a regulator of mobile emission sources (such as cars) than of stationary ones such as factories and power plants, as evidenced by its earlier success with catalytic converters and smog reduction. Whats more, while the industries regulated by cap-and-trade are local, powerful and politically organized, the state has little in the way of combustion engine production.

Despite Californias green reputation, it remains the seventh-highest oil producing state in the nation, extracting about 358,000 barrels per day, according to state data.

However, oil production has been declining for decades, and the California Geologic Energy Management Division, or CalGEM, reported that more permits have been issued to plug and permanently seal existing wells than to drill new ones since 2019. The agency issued 564 new well permits in 2021, down from 1,917 in 2020 and 2,665 in 2019.

Some experts said thats not aggressive enough.

This transition cant happen too slowly, because there is a climate crisis, and there are significant public health impacts on frontline communities, said Bahram Fazeli, director of research and policy at Communities for a Better Environment.

Although there are ambitions to phase out Californias oil and gas production completely most recently, Gov. Gavin Newsom set his sights on 2045 there has yet to be an official deadline such as the one for the gas car ban.

But the state has made some efforts to control or reduce oil production, including a ban on new oil and gas wells within 3,200 feet of homes, schools and healthcare facilities. Newsom last summer also ordered a ban on new permits for hydraulic fracturing, or fracking, beginning in 2024.

As we move to swiftly decarbonize our transportation sector and create a healthier future for our children, Ive made it clear I dont see a role for fracking in that future and, similarly, believe that California needs to move beyond oil, the governor said at the time.

Fazeli noted that a recent study out of the University of Massachusetts Amherst found that achieving that transition by 2045 is feasible in California, though it would require a significant investment: About $138 billion per year, according to the study. But the fossil fuel industry is, by nature, opposed to such an existential threat, Fazeli said, and even passing common sense legislation such as the 3,200-foot buffer zone has proven challenging.

Californias economy is not different from other economies the economy is a fossil fuel economy, he said. So California is going through this growing pain of, how do we become a clean energy economy? How do we transition from a fossil fuel economy to a clean energy economy, and also provide good paying jobs? Thats a key part of the puzzle.

Another part of the puzzle is balance, according to Kyle Meng, an associate professor of environmental economics at UC Santa Barbara.

When it comes to gasoline, you really need policies to deal with both the demand side like the new car ban and subsidies for EVs as well as the supply side, which is the production of oil, he said. One without the other would lead to unexpected, adverse consequences.

For example, reducing demand without supply could mean California ends up exporting its excess oil, Meng said, while reducing supply too quickly could leave communities that rely on the industry in bad shape. In Kern County, one of the states top producing regions, oil and gas extraction provide as much as 20% of the areas property tax revenue.

As in other sectors, equity remains a major concern, especially when it comes to the communities suffering the worst effects of oil and gas drilling, Meng said. But when considering the states climate efforts thus far, he said there has been good progress.

If you were to tell me that California would hit the states 2020 greenhouse gas goals back in 2005, I wouldnt have believed it. But California did it, he said. However, looking forward, the task for this decade is even more ambitious. The big open question is not just whether California can meet its 2030 greenhouse gas goals, but whether those goals are met in a way that doesnt exacerbate existing inequities across the state.

Although phasing out gas-powered cars is one of the states greatest priorities, that alone wont be enough. Driving habits must change, too, if the state expects to achieve carbon neutrality.

The state climate plan depends on motorists driving at least 12% fewer miles by 2030, and no fewer than 22% by 2045.

Since the advent of the automobile and the construction of the highway system, large cities like Los Angeles and San Francisco have become car-centric. Today, around 75% of daily commuting trips consist of one person driving with no passengers a practice that remains the primary mode of transportation in California.

Highway building and sprawl go hand in hand, said Susan Handy, a researcher at UC Davis who has studied strategies to reduce automobile dependence. Thats true in California, and its also true everywhere else. When we built highways, it made it possible to develop farther from city centers than ever before. And now were in a situation where weve got these sprawling development patterns and it makes it very hard to get around by means other than the car.

As the states population has risen and more cars are on the road, state officials funded highway construction and expansion to ease congestion, which ironically fostered more driving.

The only major significant decreases in miles driven occur during economic downturns and, recently, with the onset of the COVID-19 pandemic in 2020 as more people have worked remotely. However, driving has rebounded to pre-pandemic levels.

Public policy strategy to reduce driving has historically included gas tax hikes or tolls, which could serve as a deterrent. But the state could do better at investments and incentivizing other forms of transportation like biking and mass transit, Handy said.

Much of Californias plans have depended on providing financial incentives to trade in gas-powered cars for zero-emission vehicles. But some state officials have requested the state look into how driving behaviors might change if the state invests more in mass transit.

I think its tough, because were a car culture, right? Air Resources Board chair Liane Randolph said at a meeting in June. We know how to help people buy cars. What we dont know is how to help people change the culture so that they are able to ride public transit in a way thats economical and equitable and efficient for them to get to work and to school and wherever they need to go.

Infrastructure will play a huge role in Californias transition away from gas cars, multiple experts said. Charging stations will be needed to help power electric vehicles, and electricity will be needed to power those charging stations, among myriad considerations.

So far, the state has established many goals to help get there, including plans to construct at least 250,000 public vehicle charging stations by the middle of the decade; 10,000 of which should be fast chargers, according to the California Public Utilities Commission. The state also plans to require landlords of multifamily housing units to provide residents with a means to charge electric cars, though those details are still being worked out.

And its not only personal vehicles that will need the stations, but also the heavy-duty trucks that transport goods throughout the state every day. The twin ports of Los Angeles and Long Beach have the goal of being serviced exclusively by zero-emission trucks by 2035, but they have a long way to go: Only 35 of the 22,000 trucks that serve the port complex are electric, battery electric or hydrogen fuel cell, according to data from their clean truck program.

Though the state has made efforts to streamline the permit process for charging stations, mapping tools show huge gaps in their locations, particularly in inland Central California and far Northern California.

Were nowhere close to where we need to be on infrastructure, especially charging infrastructure for electric vehicles, electric trucks, electric buses, electric off-road equipment, said Lyou, of the Coalition for Clean Air. And its emerged as the most challenging thing we have to do.

Another part of the problem is that recharging the batteries of electric cars and trucks could also lead to increased greenhouse gas emissions, depending on where that energy is coming from.

If youre talking about California trying to move its emissions from gasoline cars into EVs, youre talking about probably doubling the amount of electricity demand on the grid, said Meng, of UC Santa Barbara. Wheres that going to come from? You could imagine large utility-scale solar in places like Kern County, but with the laws as theyre written now, its very hard for Kern County to get property tax benefits from a solar farm than it could from oil drilling.

Excerpt from:
Can California deliver on its zero-emission car goal? - Los Angeles Times

Want to whip up your ownrecipe for afountain of youth and slow down aging? We're going to tell you exactly how to do it. Research indicates that performing high-intensity workouts on a regular basis will foster longevity. You heard that right! High-intensity fitness is an amazing workout to slow aging and promote longevity. Ready to help yourself look and feel so much younger and healthier? We're with you, so let's get started!

The recommended amount of moderately intense aerobic exercise for Americans, according to guidelines, is a minimum of 150 minutes each week, in addition to two days of muscle-strengthening exercise. But research indicates that kicking that amount of aerobic fitness up 3 to 5 times the minimum recommended amount can drastically improve your metabolism, heart health, risk of disease, and maximize your longevity. It may sound a bit intimidating, but performing around 7.5 hours of moderate exercise each week breaks out to just over one hour every day. That's a small price to pay for a longer, healthier life, don't you agree?

According to the review, which was published in the journal Current Opinion in Clinical Nutrition and Metabolic Care, you can totally safely work out even longer than that, although the benefits derived may not increase. When you are in middle age, a strong indicator of longevity is a high uptake of oxygen, and muscle mass is an extremely foretelling component when it comes to growing older.

Related: The Lifestyle Habits That Slow Down Aging, From a 100-Year-old Neurologist

If your goal is to live a longer, healthier life, we can't stress enough just how important it is to add high-intensity interval training (HIIT) to your weekly regimen. HIIT is a workout that switches between vigorous bouts of exercise and moves at a slower pace. According to AARP, studies indicate thaton a cellular level, performing HIIT workouts can slow down the aging process.

Related: What Science Says About the Exercise Habits That Slow Aging

Researchers studied 1,567 individuals in their 70s for a period of five years (via ABC News). The participants were broken into three groups. Groups 1 and 2 performed high-intensity interval training (HIIT) or repeated training at a moderate intensity, two times each week. Group 3 performed the national guidelines for physical activity. To the researchers' surprise, Group 3 far exceeded the workouts of Groups 1 and 2, because they actually worked out more intensely those who performed their exercise at a moderate level.

According to one of the authors of the study, Maria Fiatarone Singh from the University of Sydney, "The HIIT group came out the best in terms of mortality," adding, "It increased aerobic fitness more than the other two groups. So that was significant, and it increased quality of life, both mental and physical." It's also important to know that there are many ways to plan out your workout. Singh says,"You don't have to run to be at high intensity," adding, "You can climb stairs or walk briskly uphill and you'll be at 90 per cent of peak heart rate, if you're an older adult. The idea that you have to run, which is off-putting for many people because of arthritis, is not the case, and there are lots of low-impact ways to do it."

Working out is just as important to bettering your life while you are living as it is to ward off mortality, according to Professor Wendy Brown from the University of Queensland (via ABC News). Brown also points out that while individuals of all ages can reap the benefits of regular physical exercise, continuing to do so as you grow older is crucial. She refers to the study and comments, "What was amazing was in these hundreds and hundreds of people, they went for five years," adding, "They went through knee replacements. They went through hip replacements. They went through all kinds of other health things that happen with [aging.] And then they went back and joined the group afterwards. The minute you stop doing it [exercise] as you age, the wheels start to fall off." Above all? She suggests, "I don't think it matters as long as you keep doing it."6254a4d1642c605c54bf1cab17d50f1e

Alexa Mellardo

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The Best Workout To Slow Aging and Promote Longevity, Science Reveals Eat This Not That - Eat This, Not That

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Fancy a tea break? No, we insist, really. Because a new study has linked drinking regular mugs of the stuff to living longer. So, whether you need to take a breather from a work deadline, or want to wind down with a book before bed, a cuppa will do more than help you feel calm.

The research, published in the journal Annals Of Internal Medicine, found that people who sip on at least two cups of black tea daily experienced boosted longevity. Scientists looked at the drinking habits of more than 500,000 participants and discovered that it reduced the risk of mortality by between nine per cent and 13 per cent over a decade.

While the impact may be impressive, the reasons why are still a little unclear. It is thought that the polyphenol content of tea might be responsible for improved heart health. One thing's for sure, the researchers concluded that whether you add milk or sugar to your brew, it didn't seem to make a difference.

The study also indicates that black tea - drunk by 89 per cent of participants - could be just as beneficial as green tea. The latter has long been linked to improved wellbeing, with research showing that it can help with everything from brain function to cardiovascular health.

It builds on previous investigations by scientists into the virtues of your tea break. A previous study suggested that drinking tea could improve brain structure, helping you become more organised and efficient. Meanwhile, other research indicated that it could reduce many risk factors for heart disease, including by lowering blood pressure. Hot stuff.

Talking of warming beverages, here's what experts want you to know about Starbucks' Pumpkin Spice Latte...

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Drinking two cups of tea a day is linked to boosted longevity - Women's Health UK

The annual Longevity Project kicks off Friday, Sept. 2, with the first in a series of articles on the topic of cancer. The reporting series will touch on cancer prevalence, advancements in medicine, mental health impacts, access to care and more.

The Longevity Project is a weekslong effort by the Summit Daily News to educate our readers about what it takes to live a long, fulfilling life in the High Country.

The series of articles will be published on the first four Fridays in September followed by an event Sept. 29 at 10 Mile Music Hall in Frisco featuring speaker Scott Lindgren, an expedition kayaker who has a brain tumor.

We know cancer touches every part of a community in some way, so in conjunction with the public health reporting project, were asking readers to share their stories of survival or loss as it relates to a cancer diagnosis.

Stories can be submitted at SummitDaily.com/submit-longevity and will be shared in the Summit Daily as well as in the program guide for the Longevity Project event.

Excerpt from:
Share your story of loss or survival as part of The Longevity Project series on cancer - Summit Daily

Over the years, the asphalt industry has been working hard to improve the longevity of the pavements we drive on. We have acknowledged the fact that the right treatment, on the right pavement, at the right time is much more cost-effective than removing and replacing an asset once it's beyond repair. We as an industry know this, the smart asset owners know this, and yet many pavements are left to deteriorate while new roads and other needs take priority.

"Asset owners have more pavements in need of preservation than money to preserve them," John Hickey,executive director at the Asphalt Pavement Association of Oregon said. "Managers set short-term budgets in almost every sector and that has permeated the public infrastructure sector even though the considerations driving how we budget for infrastructure necessitate a long-term perspective. Even if pavement preservation budgets initially are sufficient, funding often gets diverted to what is perceived as more pressing needs. Maybe its a new pedestrian bridge or light rail system regardless of the benefit those new assets may confer, they are often paid for out of existing infrastructure funding without consideration for the long-term effects on the overall system. We tell our kids they cant get new things until they learn to take care of what they have, but we dont live by that rule when it comes to public infrastructure."

And the problem isn't getting any better.U.S. roads received aD gradein ASCE's 2021 Report Card, retaining the D they got back in 2017. Breaking down the nation's roads into four grading categories, 41.9 percent are categorized as good, 15.6 percent as fair, 22.6 percent as mediocre and 20.1 percent as poor.

So why has there been no improvement? The simple answer is perception.

"Pavements show deterioration relatively slowly and it is easy to think they will last another season or two, which will give us time to figure out a funding," Hickey says. "The obvious problem is that the newly added infrastructure often costs more than we initially estimate and it also requires preservation and maintenance. Pavement managers are in a constant battle advocating for pavement preservation funding in a system where the people who allocate the dollars want to show constituents something shiny and new."

In order to make impactful change on the lifespan of our pavements, the industry needs to continually push a long-term preservation strategy and deploy a "fix it first" mentality when it comes to our roadways.

According to the National Center for Pavement Preservation, there are nearly 4 million miles of paved public roads in the United States, valued at $1.75 trillion. The roads and other pavements in America are a huge investment and are vital for moving people and goods in an efficient manner. Yet we let them fall into a state of disrepair.

Unfortunately, there is very little new funding in the Infrastructure Investment & Jobs Act (IIJA) specifically dedicated to repair and no new requirements on highway monies for prioritizing repair on roads and bridges. Overall the law doubled down on the practice of giving states immense flexibility with the bulk of their money and then hoping that they use that flexibility to prioritize repair.

States should consider a "fix it first" approach to using these funds.

"In 2017, the Oregon Legislature passed a major infrastructure funding bill that had multiple funding mechanisms to adequately pay for, among other things, improving bridge seismic resiliency and preserving pavements," Hickey says. "But, the final bill included earmark projects in primarily urban areas, which are notorious for taking a long time and being expensive."

As inflation continues to be a challenge for State DOTs, it they truly want to do more with less money, preservation is the answer.

If inflation wasnt bad enough, as pavement conditions decline, pavement preservation costs increase. So what are the solutions to keep up with continual pavement decline?

In Oregon, it's Thinlays.

"Thinlays are the most beneficial pavement preservation technique," Hickey says. "Added structure and improved smoothness are probably the two Thinlay benefits that are most relevant since we need pavements to support increased loading and improved smoothness can result in a significant reduction in greenhouse gas emissions from vehicles."

Thin asphalt overlays are a reliable way to restore smoothness and drivability to an aging pavement, while correcting distresses and even adding structural value in some instances.Typically, a thin asphalt overlay is a surface mix of 1.5 inches or less placed on a well prepared surface. The pavement being overlaid may be milled or unmilled, but it should not show signs of structural distress requiring a more extensive rehabilitation.

The decision to apply a thin overlay to an existing pavement surface should be made only after a careful evaluation of the pavement condition and the elimination of the need to perform a structural rehabilitation. You also need careful consideration of an entire pavement maintenance program, otherwise costs can creep up on you.

"The primary challenge in implementing a Thinlay pavement preservation program is the fact that they often have a higher initial cost and it is hard for pavement managers to overcome the budgeting hurdles described above," Hickey says. "Marion County in Oregon is an example of an agency that has had success implementing a Thinlay program, which has improved pavement conditions and set the County up for lower pavement preservation costs over the long-term."

One of the biggest benefits of asphalt pavements is their ability to be built upon, year over year, while maintaining structural strength.

"Perpetual Pavement" is the name coined to describe a layered, flexible pavement design and construction concept. Application of the concept produces a deep-strength asphalt pavement that can resist structural fatigue distress for a long time (at least 50 years) and, thus, results in a long-lived pavement. These long-lasting structural bases can be economically maintained by replacing just the surface, never needing total removal and replacement.

Perpetual pavements are designed to develop distresses from the top-down, rather than from the bottom-up. This preserves the integrity of the bottom layers of the pavement structure, and confines damage to the top layer where it can be easily managed without requiring full-depth repairs or major rehabilitation. In fact, we now know that asphalt pavements can be designed toneverdevelop bottom-up fatigue-related distress, regardless of how many loads are applied to the pavement, and how heavy those loads may be.

By confining damage to the top layer of the pavement, maintenance and rehabilitation costs over the life of a perpetual pavement are significantly reduced. And given the fact that the lower layers of pavement are preserved, the structural life of a perpetual pavement is on the order of 50 years or more, rather than the 20-year life expectancy that has traditionally been the standard.

The cost savings and increased life expectancy are huge benefits that smaller agencies and local governments cant afford to ignore. Both high-volume highways and interstates and low-volume county roads and city streets can reap the benefits of perpetual pavement too, even if those structures were not originally designed or built to perpetual specifications. Perpetual pavement can, in fact, be achieved by increasing pavement thickness one inch of asphalt at a time.

For local agencies with limited budgets, that extra inch of asphalt will pay for itself many times over by reducing long-term maintenance costs and doubling the life expectancy of the road itself.

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How the Asphalt Industry Can Improve Pavement Longevity - For Construction Pros

Many pastors, particularly newbies, have a noble aspiration to stay long term in a church. I think it is safe to say that most of us know the value of serving long-term in one place. It gives us the privilege of journeying with people as they travel through different seasons of lifesomething not possible with short-sprint ministries. It also provides the opportunity to bring about deep and long-lasting change in a church.

For many of us, long-term ministry is a dream that turns into a nightmare.

Then the harsh realities of pastoral ministry hit us like a speeding freight train. We find ourselves looking for an exit; for greener pastures somewhere else.

Too often, people enter church ministry with blissful naivety; without recognising and weighing up the cost of staying in a church long term. Its like people who love the thrill of climbing Mt Everest but who fail to understand how much it costs to get to the top. If we want to last the distance, we need to take a hard and honest look at how much it will cost us and ask if we are prepared to pay that price. So what is the cost we need to be aware of? Here are three parts to it:

We all love speed. We are always looking for things to happen faster and faster. Faster internet. Faster fast food. Faster computers. Faster microwave food. Things need to move faster. Top Guns Maverick sums it up: I feel the need; the need for speed.

If we plan to serve in one church long term, then we have to sacrifice our need for speed. Changing and growing a church can be very very very slow and by slow I mean more than a few months or even a year. Sometimes it takes decades.

Changing and growing a church can be very very very slow. Sometimes it takes decades.

I remember speaking to a young pastor who was excited about his new church. Six months into it he was still excited. After two years he was ready to pull the plug.

Of course, some churches seem to change faster than a speeding bullet. But many others move at snails pacepainfully slow for speed-lovers. But why should we be surprised? Churches are not like speed boats that can do 180-degree spins at the drop of a hat. They are like ocean liners that take a long time to change course.

Churches come with traditions, practices, values and customs that have accumulated over yearsmaybe even centuries! It will take time to decipher them, let alone change them. To think we can change the church overnight (or even in a year or two) is crazy. Just earning peoples trust will take longer than that: As the saying goes, It is hard to earn a persons trust. But it can be easily lost overnight.

However, if slowness is a problem for us, we need to remember that it isnt for God. He was prepared to wait until Abram and Sarai were old before miraculously providing their first child. He was prepared to wait 400 years before bringing Israel out of Egypt (Gen 15:12-16). He was prepared to wait 80 years before using Moses for that job. God has his own timing.

Yet things are usually happening in the meantime. When things are slow, we need to recognise that God is still at work, changing people every minute of the day in quiet and subtle ways. Even in the most hardened of churches, the Spirit of God will use the Word to bring about Christ-like transformation. It is worth remembering the book of Ruth: as the whole nation of Israel was going down the toilet (see Judges), God was at work in a country village, bringing together a Ruth and Boaz, through whom David and his greater Heir would come to the rescue.

Who likes to fail? Success is something we pursue and celebrate. We put our successful leaders on pedestals and urge everyone to be like them.

Unfortunately, church ministry often sings to a similar tune. We pick successful pastors to be guest speakers at our church growth conferences, clinging to the worldy hope that we might be able to copy their formula. Notice that one of the key questions in strategic planning is, What does success look like?

Now, Im not against being successful, and I certainly dont want to be someone who cuts down tall poppies. It is important to plan for success. But we need to remember that success is something God gives us. He may use our planning and effort, but he does not depend on them. Success is up to God, not us (see 1Cor 3:5-9).

If we are serious about long-term ministry, we need to know and be prepared for a string of failures.

If we are serious about long-term ministry, we need to know and be prepared for a string of failures. There will be people we will fail. Many sermons will go down like lead balloons. We will make wrong (if notbad) decisions that will hurt people. We will fail to give some people the attention they need. People will complain about our boring meetings. We may fail to disciple people; fail to raise up leaders; fail to visit the sick; fail to evangelise our community; fail to raise money; fail to find extra staff. We might lose our cool or say the wrong thing that causes people to leave the church.

Failure is part and parcel of any long-term ministry. This is not an excuse for failure. It is simply to recognise that we will not always get it right. Indeed, many times we will get it wrong.

That might demoralise us. A string of failures and mistakes might make us want to pack our bags and move on. But if we are serious about staying, we will have to pick ourselves up and keep pushing on. We also need to remember that while no one loves to be a failure, God loves failures and died for them. We need to remember that our failures should not define us, nor do they need to be the end of the world (though some moral failures will disqualify us from ministry).

Yet, what ultimately defines us is not what we fail to do for God but what God has successfully done for us. He loved us, not because we were so good, but quite the opposite. Remember Pauls words in 2 Cor 11:16-33. As the super-apostles paraded their super credentials, Paul paraded his failures and weaknesses. As he reminds us, it is when we are weak that Gods grace is more than sufficient. 2 Cor 12:9.

Our natural instinct for self-preservation makes us want to avoid pain at all costs. But if we are serious about long-term ministry, we will need to be prepared for hurt that will come time and time again. Many of us have a dreamy view of ministry; that it is all fun and games. If we talk about suffering, we think of it as the sort of suffering we have to endure to get fit.

But long-term pastoral ministry is not for the faint-hearted. People will complain and criticise and often unfairly. They will complain about your preaching, your leadership, your decisions, your dress code, your manner, your pay, and your attitude. People you have depended on will turn against you and stab you in the back. Church leaders will gang up on you because you are trying to do the right thing. Although you are trying to serve the church, some people will think you are leading them to deaththink about Moses. Of course, we are not Moses, but many of us probably have an idea of how he must have felt.

But again, why should we expect anything different? Although the church is Gods holy people, they are still a bunch of ratbag kids who need to grow up to become like Christ. In his graciousness, God has given us a part in this. But as any parent will tell you, raising children can be painful. In Galatians 4:19, Paul even likens his efforts to the pains a mother goes through in giving birth to a baby. This is the pain he feels until Christ is fully formed in the church. It is hard enough to endure birth pangs for an hour or two. Imagine 20 years of them!

If we are serious about long-term ministry, we need to be prepared for the years of such pain. Are we prepared to pay this cost? We need to be if we are serious about long-term ministry.

And yet, if we are serious, Gods grace and power will prove to be more than sufficient to sustain us to the very end. As Paul wraps his ministry and passes the baton to Timothy, he encourages him with these words:

For this reason I remind you to fan into flame the gift of God, which is in you through the laying on of my hands. For the Spirit God gave us does not make us timid, but gives us power, love and self-discipline. So do not be ashamed of the testimony about our Lord or of me his prisoner. Rather, join with me in suffering for the gospel, by the power of God.(2 Timothy 1:6-8, NIV)

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Longevity: Playing the Long Game in Ministry - The Gospel Coalition

New Delhi: Widely considered one of the most significant figures of the second half of the 20th century, Mikhail Gorbachev, the last president of the Soviet Union passed. Gorbachev, credited with ending the Cold Wat without any bloodshed lived till the age of an astounding 91 years, even though was suffering from long and a serious illness that has always been shrouded in mysteries. Earlier this year Gorbachev, whose biggest contribution was to provide Russians with freedom of speech and multi-party democracy, had been hospitalized for an unknown kidney ailment, which media reports said was dialysis treatment but was refuted by the Tass. The cause of his death has not been announced yet.

A few years back, Australian media had also said he was suffering from severe diabetes, a claim not verified.

Secrets of Gorbachevs longevity

According to the Tass, the Nobel Prize winner will be buried in Moscow's Novodevichy cemetery, next to his wife Raisa.

Unabashed love for family and celebration of bondsGorbachev was married to Raisa for 46 years before she died of leukemia in 1999. In the volumes of his memoirs, which he had dedicated to her, Gorbachev had mentioned being heartbroken by her death. He loved traveling and used to take short breaks with his family to rejuvenate and recuperate from the stressful work times.Gorbachev's memoirs also feature pictures from the various family holidays taken in and outside Russia.

Love of Music: A great stress buster

In the dark night, I know that you, my love, are awake, sitting by the crib you're secretly wiping away a tear; How I love your deep gentle eyes, how I want to press my lips to yours," he sang for an interview to the BBC way back in 2013.

Unfailing sense of humor

Gorbachev was also known for his humorous takes on serious politics. According to various journalists who interviewed him, especially after he left office, Gorbachev used to take a dig at himself quite often. "Look, now I need three legs to get around!" He told BBCs Steve Rosenberg in Moscow after he started using a stick to walk around. "What happened to the USSR was my drama. And a drama for everyone who lived in the Soviet Union," he chuckled as he spoke about the fall of the USSR.

Link:
Know 3 longevity secrets of the last USSR President Mikhail Gorbachev who died at the ripe age of 91 - Times Now

Longevity is an important aspect and factor when it comes to evaluating all-time athletes in any sport. The ability to maintain one's greatness is important, as it shows that someone can be a winning player over a period of time rather than having a short peak and a worse overall career.

There are a lot of legends playing professional sports currently that have elite longevity. Tom Brady is still a good quarterback in the NFL, Serena Williams has recently moved on to the third round of the 2022 US Open after upsetting her opponent, while LeBron James is still a superstar in the NBA. We are witnessing greatness all around.

Recently, Philadelphia 76ers guard Tyrese Maxey offered some praise for LeBron James, Serena Williams, and Tom Brady and their longevity. He jokingly asked about what is "in the water" that those three athletes are drinking, and it's clear that Maxey is amazed atwhat those legendary stars have been able to accomplish.

What is in the water Bron, Serena, and TB12 drinking!? At this point Im just curious!

There is no doubt that those athletes have had long and productive careers and will retire as legends of their respective sports. Most NBA fans know that LeBron James' longevity in the sport is absolutely unprecedented. Once, former player Eddie Johnson pointed out that players such as Magic Johnson and Larry Bird were "no longer relevant" by the time they were LeBron James' age, and noted that this "lets you know how great" James actually is.

Its amazing how LeBron at almost 37 is still being ripped for struggling, when he has an AD in his prime and not living up to expectations. Magic, Bird, Duncan, Hakeem, and Jordan were no longer relevant at 37. That lets you know how great LBJ is. Keep it moving."

Hopefully, we see LeBron James have another good year with the Los Angeles Lakers next year. While the team missed out on the playoffs this past season, they have revamped their roster, and perhaps that will lead to a different outcome for the next year.

As for Tyrese Maxey, he will likely be focused on trying to win a championship with the Philadelphia 76ers. Many expect him to become the third star of the franchise behind James Harden and Joel Embiid, and he definitely has the talent to do so.

Continue reading here:
Tyrese Maxey Lauds LeBron James, Serena Williams, And Tom Brady For Their Longevity: "What Is In The Water Bron, Serena, And TB12...

Auckland: New Zealand left-arm seamer Mitchell McClenaghan is worried of senior players not being valued much by the New Zealand Cricket (NZC) upon reaching a certain age.

McClenaghans fears come after pace all-rounder Colin de Grandhomme announced his retirement from international cricket on Wednesday.

A veteran of 29 Tests, 45 ODIs and 41 T20Is who played an integral hand in the success of New Zealand in recent times, de Grandhomme was selected by the Adelaide Strikers ahead of season 12 of the Big Bash League (BBL) through an inaugural overseas draft. De Grandhomme, 36, follows in the footsteps of Kiwi left-arm pace bowler Trent Boult, who too was granted a release from his central contract by NZC.

Also Read: Hope Next Year He is Not Worried About the Orange Cap

I think once youre at a certain age, youre not really valued at New Zealand Cricket. I feel like there should be some reward for longevity in this game, particularly with the way the contracts are set up with NZC.

Youre on a year-by-year contract so theres actually no security at all. Youre not an employee like you are with New Zealand Rugby, where youre on a longer-term contract where you dont need to look over your shoulder and youre on good money, said McClenaghan on SENZ Breakfast show.

McClenaghan, who played 48 ODIs and 29 T20Is for New Zealand, feels that lack of security in NZC contracts was why de Grandhomme announced his retirement from international cricket after bagging a BBL deal with Strikers.

You could lose your job tomorrow so all your security is out the window, so I can understand why Colin waited until he had a job to go to before kicking it in. I think in his mind he probably thought hed have four or five Tests left at a max and then that (would) probably be taken towards the end of his career. Thats just the nature of being a contractor unfortunately for NZC and obviously for New Zealand cricketers as well.

ASIA CUP 2022:FULL COVERAGE|SCHEDULE|RESULTS

New Zealand will be next seen in action in a three-match ODI series in Australia starting from September 6.

Get the latest Cricket News, Schedule and Cricket Live Scores here

Read more here:
'There Should be Some Reward for Longevity in This Game'-Kiwi Pacer Wants Change In Central Contracts - News18

On Friday, August 26, the CSUF Kinesiology and Public Health departments honored 33 esteemed emeriti by unveiling a portrait wall in the KHS building.

Bill Beam, kinesiology professor and chair emeritus (1983-2015) was instrumental in planning the event, bringing together alumni, current and former faculty, community members, college leadership, and, of course, the emeriti and their families.

Many notable CSUF emeriti were present for this event whose individual contributions include authoring world-class books on diving, receiving national recognition for research in veterans health and employee education for the U.S. Department of Veterans Affairs, and breaking the Chicago Cubs 108-year curse.

What a great way to honor our early leadersthe movers and shakers who brought us where we are, said Michele Wood, chair of public health. Public health started as a track in kinesiology. We are now working to establish a mental health and well-being scholarship, and re-envisioning HPRI into an entity that focuses on health equity and resilience. As a department, we are engaged, we are vibrant, we are productive, and we are mentoring future leaders.

Among the phrases that come to mind when one is honoring the people whose work, in this case, teaching, research, and service as well as their collegiality, have paved the way for those who have followed, is to say that we stand on the shoulders of giants,' said Steve Walk, chair and professor of kinesiology. While this phrase is apt, one also considers the often-used image of the tree, in our case the orange tree seen in our campus seal, for embodying longevity and wisdom, bearing the fruit that supports generations to come, establishing roots that ensure health, solidity, and longevity, and recording in its very core the successes and challenges of the past. And lets be honest, for a long time, physical education struggled for a security of place in higher education, strove to overcome cultural stereotypes, intellectual prejudices and associated hierarchies, and in its work to become kinesiology, almost came apart at the seams on some campuses. Not so much at Cal State Fullerton. Your work to build the department was done in the context of these challenges, and its successes are a testament to your shared beliefs and commitment to working collegially to bring them about.

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Kinesiology and Public Health Emeriti Honored | CSUF News - CSUF News

Two experts from Cleveland Clinic explain how a new cell-based gene therapy is helping patients with certain types of leukemia, with research into potential wider applications continues.

As World Leukemia Day approaches on 4 September, experts from global health system Cleveland Clinic are working on new immunotherapy treatments for blood cancers such as leukemia, expanding treatment options and bringing hope to patients for whom other treatments have failed.

Leukemia is a group of cancers characterized by rapid, uncontrolled growth of abnormal blood cells called leukemia cells. It can occur in children and adults and according to the World Cancer Research Fund International, it is the 13th most prevalent cancer globally.

According to Jan Joseph Melenhorst, PhD, a translational immunologist who is Director of Cleveland Clinics recently established Cell Therapy and Immuno-Engineering Program, chimeric antigen receptor (CAR) T-cell therapy is profoundly changing the treatment landscape, bringing the promise of durable remission for many patients with blood cancers such as leukemia.

Dr-Jan Joseph-Melenhorst

CAR T-cell therapy is a specialized treatment using a patients own T-cells a type of white blood cell that forms part of the immune system.

The T-cells are extracted and genetically modified so that they can recognize and destroy cancer cells, before being multiplied and infused back into the bloodstream, explains Dr. Melenhorst, who is also Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.

He added that while CAR T-cell therapy has brought new hope for many patients, there are currently several challenges to overcome in administering the treatment.

In particular, it may be more expensive than other therapies. Additionally, it has potentially serious side effects.

This limits access to treatment as the therapy needs to be administered on an inpatient basis at a specialized facility where the side effects can be managed. We are working with Clevelands Case Western Reserve University and other parties and collaborating with various manufacturers to address issues such as accessibility, safety, and costs, he says.

Dr. Melenhorst and his team are also aiming to improve the efficacy of existing CAR T-cell therapies while developing new versions for a wide range of blood and other cancers.

Their colleague, Craig Sauter, MD, is a hematologist and Director of Blood and Marrow Transplant at the Cleveland Clinic who has been using CAR T-cell therapy to successfully treat patients with leukemia and other blood cancers where other treatments have failed.

The standard of care in initial therapy for many acute leukemia patients remains cytotoxic chemotherapy, with the aim of achieving remission. In cases where first-line chemotherapy or other treatments have failed, however, CAR T-cells provide another potential treatment option for patients with B-cell acute lymphoblastic leukemia. In the FDA-approved indications, it has proved much more effective than the previous standard, which was a further round of chemotherapy, he says.

The U.S. Food and Drug Administration (FDA) has approved commercial CAR T-cell products for several types of blood cancers including acute lymphocytic leukemia (ALL) in patients who have been resistant to other treatments or whose cancer has returned after a period of remission. Clinical trials are also underway at institutions including Cleveland Clinic for CAR T-cells to treat acute myeloid leukemia (AML).

ALL and AML are two of the four main types of leukemia. The disease is classified as acute or chronic based on how rapidly the disease spreads in the body, and as myeloid or lymphocytic depending on whether the leukemia cells arise from myeloid cells, which develop in bone marrow, or from lymphoid cells, which are related to the immune system.

Dr. Craig Sauter

Explaining how the procedure works in practice,

Dr. Sauter says the first step is to extract the patients lymphocytes and insert an inactive virus that delivers new genetic instructions to the T-cells to start producing chimeric antigen receptors targeting proteins that live on the malignant cells.

Researchers take a small batch of these newly altered CAR T-cells and induce them to grow and multiply until there are enough to effectively target cancer cells.

The CAR T-cells are frozen and stored until the patient is ready to receive them. To prepare for the infusion, the patient receives a mild form of chemotherapy to prevent the immune system from rejecting the CAR T-cells.

According to Dr. Sauter, most people need to stay in the hospital for one to two weeks so their response to the treatment can be monitored and any side effects treated. The two most common side effects of CAR T-cell therapies are cytokine release syndrome (CRS) and neurological problems such as headaches, confusion, or difficulty speaking during the treatment period.

Dr. Sauter points out CAR T-cell therapy is in its early phase, but he is cautiously optimistic about its potential. In future, as a result of further research and carefully conducted studies, there may be an opportunity to identify high-risk groups who may benefit from having CAR T-cell therapy over chemotherapy in earlier lines of treatment, he says. The possibility of its application being extended to treat other forms of cancer is also very exciting.

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States.

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Hope For Leukemia Patients, Where Other Treatments Have Failed - Longevity LIVE - Longevity LIVE