StemCell Therapy

SALTILLO For Martha Webb, cooking is all about using the best and freshest ingredients available.

If you dont use good ingredients, youre not going to end up with something thats fit to eat, said Webb, 59.

Her husband, Raymond, regularly travels to Pontotoc County to buy her butter that folks in the Amish community make, and she grows many of her own vegetables and herbs.

Her side yard in Saltillo is planted with huge beds of rosemary, basil, dill, oregano, sage, Italian parsley and cilantro. Come summer, shell have tomatoes, running beans, squash and bell peppers.

Ive planted new potatoes for the grandkids to dig up and my asparagus is just about gone, she said. We had 60 heads of Romaine lettuce but only three are left now. And I love my herbs. I cant cook without fresh herbs.

The mother of two and grandmother of three learned gardening as a child.

When I was growing up, if we didnt grow it or kill it, we didnt eat it, Webb said. Daddy had a truck patch and my brothers hunted and fished and I hunted and fished, she said. The only thing Mama went to the store for was staples.

Webb, who was raised in Union County but now lives in Saltillo, went to college at Bethel University in Tennessee where she had a double major: piano and drama. She taught music at South Pontotoc and at Plantersville before moving to the Fillmore Center, an alternative school in Tupelo, to teach English.

Fillmore was an interesting job, she said. I loved those kids. The ones you could help made up for the ones you couldnt.

Webb retired early from teaching in 2015 due to rheumatoid arthritis. As long as her hands will allow her, shell continue to play the piano at Wesley United Methodist Church, a job shes held for 23 years.

Because shes busy with church Sunday mornings, she gets her Sunday dinner started early. She plans the menu on Wednesday and starts cooking on Saturday. She might serve Hawaiian ham with peas, greens and a salad, or a beef roast with potatoes and carrots, green beans and slaw.

Sometimes we have chicken, sometimes meatloaf, and sometimes my husband will smoke a pork loin or pork butt, she said. My kids have never known not having Sunday dinner. Even growing up, we had dinner together every night at the table. If you werent dead, then youd better be there.

Webb actually uses the weekends to get most of her meals ready for the week ahead.

I do quality cooking I dont just run in there and make Hamburger Helper, she said. Both my daughters can cook. Whatever is important to you is going to be important to your kids. I have the best children and the best life and I feel guilty every day for what God has given me.

1 box Duncan Hines lemon supreme cake mix

1 small box instant lemon pudding mix

1/2 cup Limoncello liqueur

1/4 cup Limoncello liqueur

4 ounces cream cheese, softened

1/2 to 3/4 cup confectioners sugar

For the cake, preheat the oven to 350 degrees. Combine cake mix, pudding mix, eggs, oil, sour cream and Limoncello in a large bowl and beat for 2 minutes. Pour batter into a greased and floured Bundt pan and bake for 45 to 55 minutes or until cake lightly springs back when touched. Cool for a few minutes in the pan, then invert onto a cake plate. Dust with confectioners sugar or glaze with Limoncello Frosting.

For the frosting, melt butter in a small saucepan over medium heat. Stir in Limoncello. Simmer for 4 to 5 minutes, stirring often. Remove from heat and using a mixer, whip in cream cheese and sugar until the frosting is thick, but still pourable. Drizzle over cooled cake.

1 precooked, smoked shank ham

1 large can sliced pineapple in heavy syrup

3/4 cup light brown sugar

1/4 teaspoon ground cloves

3/4 cup apricot preserves

Preheat oven to 350 degrees. Lightly score ham. Mix the juice from the canned pineapple with the apricot nectar. Stir in brown sugar and cloves. Using an injector for meats, inject the solution liberally into the ham. Place in a roasting pan and cover with foil. Bake for 1 1/2 hours. Uncover the ham and, using toothpicks, place pineapple slices on the fat sides of the ham, with cherries in the center of the slices. Heat any remaining sauce and add preserves. Baste the ham with this sauce every 15 minutes as the ham bakes, uncovered, another 30 minutes.

1 stick butter, room temperature

1 teaspoon vanilla flavoring

1/4 teaspoon almond flavoring

3/4 cup granulated sugar, plus extra for sprinkling

1 cup confectioners sugar

2 1/4 cups self-rising flour

This recipe must be followed exactly and in order for the dough to have the right consistency.

Preheat oven to 300 degrees. Line a cookie sheet with parchment paper.

With a mixer on low speed, whip the butter until fluffy. Add oil, egg and flavorings. Add both sugars and beat until blended. Add flour a little at a time. The dough should be soft. Roll dough into 1-inch balls and place on prepared cookie sheet. Press a smooth-bottomed drinking glass into extra granulated sugar and then press cookie balls to flatten. Bake until cookie edges are golden. Cool slightly then remove to paper towels to completely cool. Makes 3 1/2 to 4 dozen 3-inch cookies.

2 cups coarsely chopped, cooked squash

Cool squash, then mix in egg, onion and flour. Drop by rounded tablespoons into hot vegetable oil and cook until golden brown. Drain on paper towels.

1 pound ground mild Italian sausage

2 pounds Angus ground chuck

1 medium sweet onion, chopped

1 medium green bell pepper, chopped

1 (28-ounce) can tomato sauce

1 (28-ounce) can petite-diced tomatoes

1 (28-ounce) can crushed tomatoes

1/2 cup chopped fresh basil

1/4 cup chopped fresh oregano

1 tablespoon dried Italian seasoning

Brown sausage and ground chuck in olive oil. Drain off any fat. To the pan, add onion, bell pepper and garlic and saute a couple of minutes. Add remaining ingredients and bring sauce to a boil. Reduce heat to low and simmer slowly for at least 1 hour (longer is better). Stir often and add water if sauce becomes too thick. This sauce freezes well.

4 small zucchini (8- to 10-inches)

1 cup chopped red bell pepper

4 cups fresh corn (or 2 packages frozen, thawed)

1 large tomato, seeded and chopped

1 cup grated Parmesan cheese

Slice zucchini lengthwise into quarters, then slice across into 1/2-inch thick slices.

Melt butter in a skillet and add onion and bell pepper. Saute a couple of minutes and stir in corn. Season with salt and pepper and cook for 4 to 5 minutes. Stir in zucchini and cook 2 or 3 minutes, covered. Remove from heat and stir in tomato and sprinkle with cheese. Place under the broiler until the cheese is melted. Serves 8.

1 flute or batard Italian bread

1 cup cherry tomatoes, quartered

1/2 cup chopped fresh basil

1/4 cup chopped fresh oregano

1 to 2 cloves minced garlic

1 teaspoon red wine vinegar

Shredded Italian 5-cheese blend

Preheat oven to 450 degrees.

Slice bread into 3/4-inch-thick slices. Brush with olive oil and place on a greased cookie sheet. Place in oven until lightly crisped.

In a bowl, combine tomatoes, herbs, garlic and vinegar. Top bread slices with tomato mixture. Sprinkle with grated cheese and drizzle with balsamic glaze. Place back in oven until cheese is melted. Makes about 12.

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Retired teacher doesn't let arthritis slow her down - Northeast Mississippi Daily Journal

Walk to Cure Arthritis is May 13 at zoo

Posted May 10, 2017

FRASER When Matthew Dantes was 9 years old, he started to experience physical ailments most children his age couldnt comprehend. Today, Matthew, 18, has juvenile rheumatoid arthritis.

The gamut of aches, pains, joint stiffness, rashes, fevers and difficulty walking originally confounded doctors. Matthews mother, Christine Dantes, said her son was misdiagnosed for three years because doctors couldnt connect a 9-year-olds symptoms with a particular disease.

A lot of doctors dont know what this disease looks like on a child, Christine Dantes said. That is the main problem we had with Matthew.He was misdiagnosed because he didnt present the classic symptoms that an adult with arthritis would.

One pediatrician told Matthews family that he was just suffering from growing pains, adding that joints would be red and warm to the touch or even swollen if the condition was more serious.

Now, none of his joints get visibly swollen. Only his knees do.

Following the pediatricians diagnosis, the family searched for more answers. Matthew was tested for muscular dystrophy by a pediatric neurologist. Christine said the neurologist told the family that Matthew suffered from a case of cerebral palsy that was never properly diagnosed as an infant.

An orthopedic surgeon followed. Christine said the surgeon serial-casted Matthew for three weeks, due to being convinced the pain and stiffness were caused by tight heel cords.

The real problem was the arthritis was now in his ankles and serial casting literally froze them in that position, she said. By the time he got out of the casts he could barely walk and was in extreme pain. He was told by kids that he walked like Frankenstein.

Even after years of physical therapy, the pain worsened. He couldnt run or play with the other children. When he tried to join a soccer team, the coach asked if he had clubbed feet due to how he walked and ran.

After being continually misdiagnosed by a variety of medical professionals including being suggested to test for both lupus and leukemia Matthew could barely get down the stairs at home due to his knees not being able to bend.

It was heartbreaking as a parent to see your child slowly lose all the things that brought them joy, she said. He was in constant pain and it really robbed him of a big part of his childhood.

After years of reading and researching the possible cause of her sons physical discomfort, Christine was the one who made the correct diagnosis: Her son had arthritis.

She and Matthew visited a pediatric rheumatologist, where blood work, an inflammation panel and an MRI were performed. Days before his 12th birthday, it was confirmed he had juvenile rheumatoid arthritis. Though by that time, years of incorrect medical opinions created joint damage and contractures that were irreversible.

Matthew had permanent limitations. Christine said her son has good days and bad days, and then some really bad days. He suffers from arthritis in his knees, elbows and ankles; pain and stiffness are in his wrists, fingers and hips.

There was a hope he would enter medicated remission, but that dream faded this past February, when he had an arthritic flare and was simultaneously diagnosed with Crohns disease.

Its believed that Crohns occurred after Matthew started taking a biological drug called Enbrel at the end of last summer. It was explained that patients who take Enbrel for arthritis are at risk of side effects of inflammatory bowel disease. Now, its another thing for Matthew to endure.

Many people dont realize that arthritis is not just an old persons disease, and its not just the pain and stiffness that is a daily struggle, Christine said. The side effects from these drugs are real, and so are the risks that come with taking them.

Its heartbreaking as a parent to wonder what kind of future your child is going to have.I worry, will the damage to his body be from the arthritis, or from the drugs he has to take to control the disease?

Walking in solidarity Matthews condition affected his family and friends in a profound way.

Christine said Matthew never wanted to come across as a victim, and he hates being the center of attention. He doesnt even like bringing up his ailments, she added, or talking to the media.

Bringing awareness to the issue is important for him, however, and his old school has provided a positive avenue for Matthew to feel endeared while simultaneously helping to fight the diseases that literally cripple his body.

On May 13, at the Detroit Zoo, the 2017 Detroit Walk to Cure Arthritis will take place. As of press time, 17 friends and former classmates of Matthews at the Arts Academy in the Woods in Fraser were scheduled to walk in the event.

Christina Martin, parent liaison at Arts Academy in the Woods, is also a longtime friend of Christine Dantes. Martins kids grew up with Matthew. When Dantes told Martin that Matthew who normally walks every year possibly wasnt going to make the event, she took matters in her own hands.

She began to raise funds, sharing information through Facebook and the Arthritis Foundation. Money was raised for Arts Academy students participating in the walk, including bags filled with special items.

Now, there are approximately 13 walkers and four backups as part of the group Movin for Matthew.

Just this past year things have really been tough, Martin said. (Matthew) was going through so much. I thought it would be kind of a cool idea for us to do it in his name.

After losing 20 pounds and spending nearly his entire second semester of college homebound, Matthews inflammation is being properly controlled through medication. Hes on high doses of prednisone, which is temporary, and a biological drug called Humira.

We are hoping his medications continue to keep his inflammation down, Christine said. If they do, and I really hope they should, Matthew will be able to participate in the walk.

I dont want to mislead anyone and make them think that Matthew is worse than he is right now.He is definitely doing better and whether or not it stays that way is to be determined, but right now we are counting our blessings.

For more information on the walk, visit walktocurearthritis.org.

About the author

Nick Mordowanec covers Fraser, Clinton Township, Fraser Public Schools, Clintondale Community Schools and Baker College for the Fraser-Clinton Chronicle. Nick, a graduate of Michigan State University, has worked for C & G Newspapers since 2013 and has won awards from the Society of Professional Journalists Detroit Chapter and the Michigan Press Association. He has slight obsessions with Seinfeld and Led Zeppelin.

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Teen suffering from arthritis gets a little help from his friends - C&G Newspapers

The Indy 500 legend has been through several highs and lows recently. Clark Wade/IndyStar

Indianapolis 500 legend A.J. Foyt.(Photo: Clark Wade/IndyStar)Buy Photo

Its been a long and wild ride, and A.J. Foyt has enjoyed nearly every second of it.

I had a lot of fun, the 82-year-old racing legend told IndyStar on Wednesday at his racing garage in Speedway. If I passed out talking to you right now and fell on the floor, at least I made good money, had a happy life and what else can you ask for? So many people are so miserable with their jobs and that. I had a wonderful job doing what was fun.

Foyts job driving into racing's history books provided him with a lifetimes worth of close friends, amazing stories and thrilling adventures. But it also often required him to put his life on the line.

"I guess I was a little bit crazy back in those days,"Foyt, who walks with a limp but without assistance, said with a smile.

But being crazy was part of the job, he said. He needed it to overcome his fears.

"A lot of race drivers you talk to these days say they've never been scared in racing," Foyt said. "Well, they're lying to you and they're lying to themselves. I cannot name you one race at one time or another thatI didn'tscare the hellout of myself. Honestly. I don't know if that's good or bad, but I'm just being honest with you."

Read more from Jim: Alexander Rossi is starting to feel at home in Indy

This year's Indy 500 crowd is on pace to pass 300,000

Despite thosehealthy fears, his long and prestigious racing career resulted ina laundry list of injuries and eventual ailments that would and have horrifieddoctors.

The four-time Indianapolis 500 champion has stared death and dismemberment in the face more times than hed care to count, dealing withcar wrecks, killer bees, a bulldozer accident, heart ailments and two staph infections. As a result, hes nearly had his feet amputated,broken his back two or three times, has two false knees and a false hip, a titanium plate in his chest from open heart surgeryand said hell be on antibiotics for the rest of his life because of the amount of metal he has inside of him.

But he's far from discouraged and fightsto keep going with the same vigor and courage the colored his youth. One way he's done so recently is by undergoing stem cell therapy.Foyt said his wife, Lucy, who suffers from diabetes and arthritis, suggested that they both take on the treatment in order to try and find "the fountain of youth."

I mainly did it for her, Foyt said. She got sugar diabetes real bad, and (is) pretty sick, but, of course, I did it for myself too, dont get me wrong. But shes really been suffering the last five or six years. So we just thought wed try it.

A.J. and Lucy Foyt spent seven days in Cancun, Mexico the treatment is not performed in the United States undergoing a therapy he said likely wont take effect for another month at least. A.J. Foyt had adult stem cells injected into each shoulder and ankle, as well as into his blood.

Theres no guarantees the treatment will help either of them, but the uncertainty doesnt bother him.

I figure if we gain something, fine, and if we dont, well, Ive lost before," Foyt said.

But giving Foyt an edge in his fight against injury, ailment and Father Timeis a competitive fire that has burned within him his whole life.

A little more than a month ago, Foyt and fellow driving legend Dan Gurney were honored in Long Beach, Calif., for the 50th anniversary of their all-American victory at 24 Hours of Le Mans. Many racing greats attended the event, and Foyt was happy to see them, but he couldn't help but stackhimself up one more time against his old rivals.

I guess Im doing better than them, Foyt said with a smile. Poor Parnelli (Jones) has a lot of back trouble. Dan was in a wheelchair. Last three or four years Ive been going in and out of them, but Im still going pretty strong. So far Im hanging in there pretty good. ...Every days a good day. And Iguess thats good when youre getting ready to kick."

Follow IndyStar Motor Sports Insider Jim Ayello on Twitter and Instagram: @jimayello.

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AJ Foyt on fear, his stem cell therapy and more - Indianapolis Star

Updated: May 9, 2017 - 6:06 PM

FOX13 consumer advisor Clark Howard says new research shows there may be a way to fill cavities by re-growing part of the tooth itself.

Fillings are one of the most common and least expensive dental procedures in America.

JohnSiewekeis the Dental Director at Good Samaritan Health Center in Atlanta. He says while common, fillings are also technique sensitive.

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If you do not follow that technique then you aregonnaget leakage between the tooth and the filling and that'sgonnalead to more decay and more break down and potential pain,Siewekeexplained. Depending on how far that is allowed to go could lead to the loss of the tooth.

Now a team of researchers at Kings College in London think theyve found a way to fill cavities, by stimulating a process that already takes place naturally when a tooth is damaged.

Teeth are a mineralized organ. Highly complex, they contain 2 different types of mineral; the enamel, which is the stuff on the outside that you see and underneath they have another mineral called dentine and right in the middle they have a soft tissue which has got blood supply and nerves, Paul Sharpe said.

Sharpe explained that when damage occurs, stem cells in the pulp are activated and begin the process of producing Dentine to repair the tooth, but it only works when the damage is small.

When the damage is big it just can't cope, the process is not robust enough to repair big holes ... i.e., when a dentist has drilled out decay, he said.

Thats where Tideglusib comes in. Sharpe and his team used the drug to stimulate the process of dentine production in mice.

They placed a small amount of the drug on a sponge and inserted it in the tooth of a mouse where a hole was drilled. The result, Sharpe said, was a massive stimulation of the natural process.

So you get dentine formed and it completely fills the tooth, Sharp said. So the hole that's drilled is now filled with the natural material that's been removed that the tooth has created itself.

It took two to four weeks for the dentine to grow back. Sharpe says its a strong natural repair that could prevent more damage down the road.

Failure with the conventional treatment where you are using cement is that the cement can crack, Sharpe explained. You can get fissures and that can lead to a reinfection of the tooth and there you have to go back to the dentist and have a new one put in.

According to the National Association of Dental Plans, 114 million in the U.S. had no dental coverage at the end of 2016, so making sure new treatments are affordable is key.

Thats one of the reasons Sharpe and his team chose Tideglusib.

It had already been used in patients for treatments in neurological disorders such as Alzheimers, he said. So that means this drug has been used systemically into the bloodstream at high concentrations ... and there is safety data ... so all the costs of drug development -- safety trials and everything else -- we don't have those. That's why I think among other things it could be cost-effective treatment.

Its also a relatively simple process, which also helps to keep cost down.

It's very uncomplicated, Sharpe said. Dentistry is massively high volume/low cost treatment -- so anything that's really over-complicated and expensive is never going to make the market.

It will still be about two years before there are human trials, but Sharpe stresses that even if this treatment goes mainstream, the drug is only meant to repair damage.

Sieweke agrees and says prevention is the best way to keep your dental costs down.

I think a lot of times that is getting lost in the real day-to-day treatment world. The focus is, What's broken? How do we fix it? And unfortunately too often also, What's the cost? And the cheapest way to bring down the cost of dental care is to prevent it, Sieweke said.

Clark says hes excited for the future.

You never know with science, but I think this one is the real deal for your mouth and mine, Clark said.

The best way to keep your dental bill down is to brush your teeth. Do you know how to do it correctly? Clark recently learned that he did not.

2017 Cox Media Group.

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Never get another filling? Drug helps regrow your teeth | FOX13 - FOX13 Memphis

United News of India

International Stem Cell Corporation Receives Approval to Start Second Patient Cohort in Clinical Trial for Parkinson ... P&T Community CARLSBAD, Calif., May 09, 2017 (GLOBE NEWSWIRE) -- International Stem Cell Corporation (OTCQB:ISCO), a California-based clinical stage biotechnology company developing stem cell-based therapies and biomedical products, today announced that that the ... Public sector stem cell bank at KGMUUnited News of India all 9 news articles »

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International Stem Cell Corporation Receives Approval to Start Second Patient Cohort in Clinical Trial for Parkinson ... - P&T Community

CANCER is currently one of the top killers worldwide, and the number of cancer cases is only expected to rise. Although there are a number of therapies available, most of them are toxic and cause serious side effects. New research examines the impact of the natural vitamin C on cancer cell growth.

In a recent study, vitamin C proves effective in killing cancer stem-like cells. Cancer is the second leading cause of death and disease worldwide, accounting for almost 9 million deaths in 2015, according to the World Health Organization (WHO).

The global number of new cases of cancer are expected to grow by around 70 percent in the next 20 years. In the United States, the National Cancer Institute (NCI) estimate that almost 40 percent of U.S. men and women will have developed cancer at one point during their lives. There are various treatment options available for cancer, but they are not always effective; most of them are toxic, and they tend to have a variety of side effects.

In some more aggressive cases, the cancer does not respond to treatment, and it is believed that cancer stem-like cells are the reason why the cancer comes back and metastasizes. New research, published in the journal Oncotarget, examines the effectiveness of three natural substances, three experimental drugs, and one clinical drug in stopping the growth of these cancer stem cells (CSCs.)

The study was conducted by researchers from the University of Salford in Manchester in the United Kingdom, and was led by Dr. Gloria Bonuccelli.

In total, the researchers measured the impact of seven substances: the clinical drug stiripentol, three experimental drugs (actinonin, FK866, and 2-DG), and three natural substances (caffeic acid phenyl ester (CAPE), silibinin, and ascorbic acid (vitamin C).) The research focused on the bioenergetic processes of CSCs, which enable the cells to live and multiply. The study aimed to disrupt the CSCs metabolism and ultimately prevent their growth.

Of all the substances tested, the team found that actinonin and FK866 were the most effective. However, the natural products were also found to prevent the formation of CSCs, and vitamin C was 10 times more effective than the experimental drug 2-DG. Additionally, the study revealed that ascorbic acid works by inhibiting glycolysis the process by which glucose is broken down within the cells mitochondria and turned into energy for the cells proliferation.

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Vitamin C can kill cancer stem cells, study shows - Kashmir Watch

DorcasAdetudimu, like the average 12-year-old girl, likes to dance, play the piano and sing. Buta rare disease means she can't do those things for very long without getting sore and tired.

Her family is now appealing to the city of Brandon for help findinga stem cell match so she can have a chance at a normal life.

Adetudimuwas diagnosed with sickle cell disease when she was just six weeks old. The condition, common among those of African descent, is a gene mutation that causes the red blood cells to take a crescent shape, making it hard for oxygen to flow around the body.

"I can't do some things that other kids can do," she said, adding that something as simple as going for a swim can cause her body to go into crisis.

"I feel like I'm very limited to doing stuff," said Dorcas. The condition has led to severe pain and regular hospital stays that sometimes last for weeks at a time.

Her condition has worsened over the years. She now requires blood transfusions every four weeks. Last November, she was admitted to the intensive care unit at a Winnipeg hospital and put into an induced coma while doctors deflated her lungs and transfused all of her blood.

This June 2014 image provided by the National Institutes of Health, shows red blood cells in a patient with sickle cell disease at the National Institutes of Health Clinical Center in Bethesda, Md. (The Associated Press)

"It's a painful thing to see your child in pain," said her mom, Juliette. "That was the worst crisis she has ever had. She'd never been in the ICU before."

Juliette, who is originally from Nigeria but moved to Brandon five years ago with her four children, was told the only chance her daughter would have at a normal life would be through a stem cell transplant. Unfortunately neither Juliette nor any of her three other kids were a match.

"I thought that was it," she said. Adetudimu knows of only two other people in Brandon with sickle cell disease, which is rare in Manitoba and Canada, but common in African nations.

With the help of a family friend, Juliette started organizing a stem cell drive through Canadian Blood Services. She's hoping to get as many people as possible between the ages of 17 and 35 to register and submit a cheek swab on May 17 at the Shopper's Mall in Brandon in the hope of finding a match locally.

Since word of the drive got out, complete strangers have been contacting her wanting to help in any way they can.

"It [is] so overwhelming," Juliette said. "I didn't realize people were going to respond this way."

She said a neighbour, who she hadn't met before, showed up on her doorstep asking how he could help.

"Its encouraging to see this kind of support from people that you don't even know."

She's hoping to not only find a match for her daughter, but to also educate the city's ethnic community, and the public, about sickle cell and the importance getting on the stem cell registry.

"Even if they don't match Dorcas, they can still match with somebody else," she said.

Until a match is found, Dorcas will need frequent transfusions. Juliette isn't losing hope.

"I believe in miracles. Nothing is impossible," she said. "I am hopeful ... [a match] would change everything for Dorcas and the family."

The stem cell drive takes place at Brandon's Shopper's Mall on May 17 between noon and 9 p.m.

Dorcas (bottom right), with her mom and three other siblings in their Brandon, Man., home. None of her family members tested positive as a stem cell match for Dorcas. (Riley Laychuk/CBC)

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Brandon family appealing for stem cell match to cure girl's sickle cell disease - CBC.ca

GETTY

Blepharitis - also known as lid margin disease - is a potentially sight-threatening ocular condition, but only one in four British people know it exists.

Despite the fact it can lead to ulceration of the cornea and permanent damage to vision, there are many people who remain undiagnosed with the condition.

According to Moorfields Eye Hospital, one in six people in the UK displays symptoms.

Signs include crusty deposits around the lashes, gritty and painful eyes, and irritation around the eyelids.

GETTY

Burning or gritty eyes can lead to the condition, which accounts for one in 20 GP appointments for eye problems.

Abnormal eyelash growth, finding contact lenses uncomfortable to wear, and increased sensitivity to light are also indicators.

Burning or gritty eyes can lead to the condition, which accounts for one in 20 GP appointments for eye problems.

Experts believe it is being fuelled by insomnia, sugary diets, air conditioning and spending long hours at a computer screen.

However, according to a survey by eye-care specialists Bausch + Lomb, two in five people have no idea what causes it.

1 of 8

Ole Henriksen Ultimate Lift Eye Gel, 35 (0207 235 5000) Avoid if you have sensitive eyes because the gel can sting the first few times you apply it. Eyes do appear less puffy after a weeks use though. 6/10

GETTY

They also found 40 per cent of us have no idea how to manage it.

But if its not treated, or does not respond to therapy, it can lead to blindness.

While it cant be cured, you can control the symptoms and prevent permanent scarring of the eyelid margins, according to the NHS.

Francesca Marchetti, leading ocular expert and a member of the WINK advisory eye-care panel, said: Given how many people are affected by blepharitis, and the implications for vision if it is not managed effectively, these findings are extremely worrying.

GETTY

The first line treatment for blepharitis is using a combination of heat therapy, eye massage and good eyelid hygiene every day, this will manage the condition and in many cases will prevent further flare-ups.

A combination of cleansing the eyelids with special wipes and heat therapy can help.

The National Institute for Health and Care Excellence (NICE) advises: Eyelid hygiene is essential and this should be continued even when symptoms are well controlled.

They suggest applying a warm wipe to the closed eyelids for 5 to 10 minutes to loosen the debris and softens any deposits of meibum, an oily substance which protects the tear film but can problematic if the meibomian glands are blocked, or the meibum is too waxy.

Marchetti added: To have a therapeutic benefit, the heated compress must be a consistent 40 to 45C, and remain at that temperature for at least five minutes. But if it is any higher, or there are more intense hot-spots, there is a very real risk of burning or damaging the sensitive tissues around the eye.

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This is what your gritty eyes could mean - Express.co.uk

Mississauga

Hundreds to pull cargo plane to fight blindness Mississauga Hundreds of enthusiasts will be pulling a giant 60-ton cargo plane later this month to fight blindness and help restore vision to millions of people across the globe. Orbis Canada, a Canadian organization that works to deliver accessible quality eye ...

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Hundreds to pull cargo plane to fight blindness - Mississauga

The Reach Cambridge Biotechnology course introduces students to both the academic study of biotechnology and its exciting practical applications in the real world. This fast-growing area of modern science has the potential to fundamentally alter how we produce food, treat disease and create medicines. Topics covered include genetics, drug resistance, pharmaceutical science, biotechnological devices and drug design. Through lectures by experts in the field and hands-on practical sessions, students will be offered a unique insight into both the study of biotechnology at university and the vocational opportunities in the field beyond higher education.

This exciting and dynamic course will be a rewarding program for all those who have a passionate interest in biotechnology and biological sciences. During the Scholar program, the Biotechnology course is academically intensive and intellectually challenging, focused on the complex scientific problems which the discipline is in the process of tackling.

All Reach Cambridge courses are open to students aged between 14-18 years old.

All courses are taught in English. In order to get the most out of the learning experience, students are advised to have a level of English conducive to understanding sophisticated academic language and to converse with other students and staff in English at all times.

We do offer English as Second Language courses if you, or we, feel that this is more appropriate. Your personal statement will help indicate to us your level of English. We will also ask for a copy of your latest school transcript to help us assess the teaching level of the courses.

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BioTech Jobs in the BioTechnology Pharmaceuticals Industry

Healthcare conglomerate Johnson & Johnson said on Monday the U.S. Justice Department has opened an investigation concerning management and advisory services provided to rheumatology and gastroenterology practices that bought two of its drugs.

The U.S. healthcare company said its Janssen Biotech Inc unit received a civil investigative demand from the Justice Department regarding an investigation under the False Claims Act related to its arthritis drugs Remicade and Simponi Aria.

J&J also revealed in its quarterly filing that the U.S. Attorney's Office in Massachusetts is seeking documents broadly relating to pharmaceutical co-payment support programs for hepatitis C drug Olysiotm, Simponi and Crohn's disease drug Stelara. (bit.ly/2qUhznX)

That office's subpoena also seeks documents relating toaverage manufacturer price and best price reporting to the Center for Medicare and Medicaid services related to those products, as well as rebate payments to state Medicaid agencies, Johnson & Johnson said in the filing.

(Reporting by Akankshita Mukhopadhyay in Bengaluru; Editing by Bill Trott)

WASHINGTON The U.S. economy will fall short of the Trump administration's goal of 3 percent growth this year and will only achieve that when its regulatory, tax, trade and energy policies are fully in place, Commerce Secretary Wilbur Ross said on Tuesday.

News Corp reported better-than-expected quarterly revenue as the owner of the Dow Jones Newswires and the Wall Street Journal saw an uptick in its digital real estate business and growth in its advertising revenue.

A decline in subscribers and higher programming costs at cash-cow ESPN weighed on shares of Walt Disney Co on Tuesday, overshadowing a quarterly profit that topped Wall Street estimates.

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J&J discloses US probe related to arthritis drugs - Reuters

Arthritis in the hands more common than you might think, study says Wichita Eagle Arthritis in the hands is more common than you might think. Nearly 1 in 2 women and 1 in 4 men will develop the condition in their lifetime, according to a new study. The risk of symptomatic hand osteoarthritis also varies by race and weight. Aching or ...

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Arthritis in the hands more common than you might think, study says - Wichita Eagle

the Irish News

Survey reveals impact of arthritis on mental health - The Irish News the Irish News A survey released by Arthritis Care reveals the hidden impact that living with arthritis has on people's mental wellbeing. Of those surveyed in Northern Ireland 83 ... Survey unveils 'enormous hidden impact' arthritis has on mental ...ITV News Fundraising dinner success for Arthritis Care | News | Tenby ObserverTenby Observer all 4 news articles »

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Survey reveals impact of arthritis on mental health - The Irish News - the Irish News

May 9, 2017 Credit: Vetsuisse Faculty, UZH

The intervertebral disc is the "shock absorber" between the vertebrae of the spine, cushioning every step, bend and jump. If the fibrocartilage tissue in the spine degenerates over time, an intervertebral disc can "slip" pinching the medulla or nerves. The consequences include intense pain or even paralysis. Dogs and people are often susceptible to this disease. Since intervertebral discs themselves cannot regenerate, the affected disc material is removed in an operation that can be performed on both people and animals. The pressure on the nerves and medulla disappears, but the degeneration of the disc remains.

Frank Steffen, neurologist at the Clinic for Small Animal Surgery at the Vetsuisse Faculty of the University of Zurich, has developed a stem cell therapy for the condition. Stem cells are multipotent cells that can be differentiated into various cell types. Steffen hopes that the stem cells will possibly form new disc cartilage once injected into a damaged disc. His study on three sick German shepherds demonstrate that treatment with the body's own stem cells is well tolerated an important first step.

Gaining knowledge directly from the afflicted animal

Research on intervertebral disc regeneration is frequently performed using animal testing. At the Clinic for Small Animal Surgery in Zurich, researchers have taken another path: "Since we treat numerous dogs who spontaneously sustain a slipped disc every year, we have been able to gain important knowledge directly from animals that are actually afflicted with this disease," Steffen explains. "Due to the similarity in pathology and the course of the illness, conclusions can presumably be drawn for the treatment of affected persons as well." The project for the development of stem cell therapy in dogs is being conducted in cooperation with Swiss Paraplegic Research (SPR) in Nottwil, Switzerland.

With the permission of the dog owners, Steffen and his team removed stem cells from the marrow of the pelvic bone of the affected animals. After the cleaning and preparation of the cell material in the laboratory, the stem cells were injected into the degenerated intervertebral disc during an operation. "Our objective is for the stem cells to trigger cellular and molecular repair processes and, ideally, to form new intervertebral disc cells in order to contribute to the regeneration of the tissue," Steffen says.

After tolerability, check effectiveness

The results are promising: The three dogs tolerated the injections of their own stem cells and the researchers have determined no negative effects. However, later X-rays and magnetic resonance tomographies did not show clear indications that the damaged discs have regenerated in comparison with the control group.

Steffen says, "Proving the tolerability of the therapy was our first important step." Now, he is working on the effectiveness of the stem cell injections with the targeted addition of growth factors. "If our method proves successful one day, it would be a pioneering step for human medicine as well," the neurologist says.

Explore further: MRI can visualize effects of traction on herniated discs

More information: Frank Steffen et al. Bone Marrow-Derived Mesenchymal Stem Cells as Autologous Therapy in Dogs with Naturally Occurring Intervertebral Disc Disease: Feasibility, Safety and Preliminary Results, Tissue Engineering Part C: Methods (2017). DOI: 10.1089/ten.TEC.2017.0033

Certain blood vessels in the brainstem constrict when blood vessels elsewhere in the body would dilate. And that contrary behavior is what keeps us breathing, according to a new paper by UConn researchers published May 8 ...

Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.

Researchers from North Carolina State University and the University of North Carolina at Chapel Hill have developed a new technique that uses modified insulin and red blood cells to create a glucose-responsive "smart" insulin ...

New research from Boston Children's Hospital and Beth Israel Deaconess Medical Center (BIDMC) shows that chronic sleep loss increases pain sensitivity. It suggests that chronic pain sufferers can get relief by getting more ...

A team of researchers at Cambridge has identified how areas of the brain govern both our emotions and our heart activity, helping explain why people with depression or anxiety have an increased risk of cardiovascular disease.

An international study led by researchers at Monash University' Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, ...

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Stem cells therapy for naturally occurring intervertebral disc disease - Medical Xpress

Myopia exists when light focuses in front of the retina, rather than on top of it. | Courtesy of David Gee/College of Optometry

The University of Houstons College of Optometry is leading the charge in the fight against myopia, or nearsightedness, with several studies aimed at discovering how to fully stop the progression of the condition in children a problem that can lead to permanent blindness.

Dr. Earl Smith, Dean of the UH College of Optometry, wasnamed one of the Most Influential in Optometryin 2015 for his extensive research into myopia and was recently awarded a $1.9 million research grant by the National Eye Institute to help fund hisongoing work. Dr. David Berntsen is part of a clinical trial for childrens contact lenses that builds off of some of Smiths work, and Dr. Ruth Manny worked on two studies that tested eyeglasses and looked for myopia risk factors.

Were in the middle of an epidemic of myopia, Smith said. In Asia, East Asia, for example: Japan, Hong Kong, Taiwan, Singapore if you look at the kids graduating from technical high schools in urban areas, 80 to 95 percent are nearsighted, and theyre not a little bit nearsighted. Theyre a lot nearsighted.

Myopia exists when the eye grows too long on its axial length, Smith said, so light from a faraway object focuses in front of the retina, rather than on it. This causes objects at large distances to look blurry.

The myopia epidemic, Smith said, is likely caused by intense educational practices and lack of time outside for children. Sitting indoors, reading and studying for long hours does not give the eye enough variety in distance or exposure to sunlight. Everything inside is close to the eye, Smith said, while everything outside is far away, giving the eye the needed signal to slow growth.

Myopia is one of the largest causes of permanent blindness in Asia, he said, and the condition is taking hold in the United States. From 1970 to 2000, the number of myopia sufferers in the adult population jumped from to 45 percent from 25 percent. Those with severe myopia increased by a factor of eight, Smith said.

An estimated five billion people half of the earths population will be nearsighted by 2050 if nothing is done about the epidemic, Smith said. One billion of those five billion people will have severe myopia, Smith said, which is likely to lead to permanent blindness.

Glasses and contact lenses are the most common ways to correct nearsightedness, Smith said, because they changethe focus of the light received by the eye so that it comes to rest on the retina.

Smith said the goal of his research is to understand the role of vision in affecting eye growth. The eye has corrective systems in place so that during development, if vision is blurry, the eye will grow to correct it.

At first, Smith said, his research was focused on those suffering from lazy or crossed eyes. His focus shifted once he foundthat visual experience plays a key role in the development of those conditions and myopia.

Vision regulates the way the eye grows, whether one is nearsighted or not, Smith said. Its a fascinating thing. The eye uses visual feedback associated with defocus to regulate the way the eye grows. Because of changes in our behavior, those systems sometimes operate in ways that cause the eye to become nearsighted.

Smith said the biggest contribution his research made was proving that the periphery vision could dominate eye growth. If corrective bifocal contact lenses are applied, giving the wearer clear vision while simultaneously correcting the peripheral vision, eye growth will be slowed and myopia can be avoided, Smith said.

Dr. David Berntsen,an associate professor at the College of Optometry and fellow recipient of funding from the National Institutes of Health, is working on the Bifocal Lenses In Nearsighted Kids clinical trial.

My funding and the primary work in my lab is clinical trials in kids, looking at specific types of lenses to see if they can slow myopia progression, Berntsen said.

The funding Berntsen received is a different type of grant system that funds large-scale clinical trials, he said. The BLINK study is a collaboration between UH researchers and colleagues at Ohio State University.

BLINK enrolled about 150 kids at UH and 144 at Ohio State University, aged 7 to 11-years-old, over the course of about a year and a half, Berntsen said.

Berntsen explained that each child is randomly assigned one of three kinds of contact lenses. The control lens is one that is normally prescribed to correct myopia.The other two are bifocals with varying degrees of plus-power in the periphery of the lens focusing the light sooner at the edges, controlling eye growth according to the findings of Smiths research.The peripheral light is then focused in front of the retina, which sends a signal to the eye to slow growth.

Traditional lenses give the wearer clear central vision, but peripheral light focuses behind the retina, which may stimulate the eye to grow longer,which exacerbates myopia, Berntsen.

Corrective lenses are the standard of care for treating myopia, Berntsen said, so there are no studies comparing myopic progression with lenses versus no lenses.There are studies that have found that peripheral light focused behind the retina like with traditional spectacles is associated with faster progression than when peripheral light is focused in front of the retina,like with Berntsens bifocal contacts.

Berntsen said the ultimate goal of his research is to stop eye growth in myopic children, but currently it can only be slowed.

Another College of Optometry professor, Dr. Ruth Manny, was involved in a similar study in 2008. The Correction of Myopia Evaluation Trialaimed to understand differences in the progression of myopia in children wearing different types of eyeglasses.

The question COMET was designed to answer was: Is the increase in nearsightedness that occurs as children get older different between children who wear eyeglasses with progressive additional bifocals (no line bifocal) and children who wear conventional single vision spectacle lenses? Manny said in an email.

There were 469 children enrolled in four different cities: Houston, Boston, Philadelphia and Birmingham, Alabama. Manny said that after three years of study, researchers found that while myopia progression was less in those children wearing bifocals, the difference was too small to recommend no-line bifocals as a method to treat myopic children.

The results of COMET have led researchers to explore different treatments, Manny said, such as the bifocal contact lenses in Berntsens study.

Manny was also involved in a study called theCollaborative Longitudinal Evaluation of Ethnicity and Refractive Errorthat looked at 13 risk factors for myopia in children, and found that refractive error, orlight focusing incorrectly within the eye, was the single best predictor of the condition.

Despite working within the same college at UH, Smith, Berntsen and Manny are not directly involved in each others research, they explained.

[emailprotected]

Tags: College of Optometry, myopia, nearsightedness, optometry, research, UH College of Optometry

Does the construction along Spur 5, which will eventually impact the U.S. 59 north and south on-ramps from I-45, affect your commute to class?

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College of Optometry researchers fight myopia, blindness - The Daily Cougar

(Press Release) Studies show there is a gender gap in eye disease. Women are more likely than men to suffer from sight-threatening conditions such as age-related macular degeneration, cataracts, and glaucoma.

In support of Healthy Vision Month in May, Marianas Eye Institute and the American Academy of Ophthalmology remind women to make vision a top priority.

Women make up 65 percent of macular degeneration cases; 61 percent of glaucoma and cataract patients are women, and 66 percent of blind patients are women. Why the inequity? There are a few theories. On average women live longer and many eye problems are age-related. Some eye conditions, such as dry eye, are more common in women, young and old. Social and economic factors affect womens access to eye care, especially in developing countries.

Whatever the cause, there are a few unique vision problems women need to watch out for more than men. Dry eye occurs at double the rate in postmenopausal women. In general, women are more susceptible to autoimmune diseases than men, many of which affect vision, such as lupus, Sjogrens syndrome and hyperthyroidism. Also, pregnancy can cause vision changes due to the hormones pregnant women experience.

Good news is most vision loss is preventable. Marianas Eye Institute and the academy offers five simple steps to take control of your eye health today:

Get a comprehensive medical eye exam at age 40. Early signs of disease or changes in vision may begin at this age. An exam by one of Marianas Eye Institutes specialists is an opportunity to carefully examine the eye for diseases and conditions that may have no symptoms in the early stages.

Know your family history. Certain eye diseases can be inherited. If you have a close relative with macular degeneration, you have a 50 percent chance of developing this condition. A family history of glaucoma increases your glaucoma risk by four to nine times. Talk to family members about their eye conditions. It can help you and your eye specialist evaluate your risk.

Eat healthy foods. A diet low in fat and rich in fruits, vegetables, and whole grains, benefits the entire body, including the eyes. Eye-healthy food choices include citrus fruits, vegetable oils, nuts, whole grains, dark green leafy vegetables and cold water fish.

Stop smoking. Smoking increases the risk for eye diseases such as cataract and age-related macular degeneration. Smoking also raises the risk for cardiovascular diseases which can indirectly influence your eye health. Tobacco smoke, including second-hand smoke, also worsens dry eye.

Wear sunglasses. Exposure to ultraviolet UV light raises the risk of eye diseases, including cataract, fleshy growths on the eye and cancer. Always wear sunglasses with 100 percent UV protection and a hat while enjoying time outdoors.

Eye exams arent only about checking a persons visual acuity or sharpness, but also determining the overall health of their eyes, said Rebecca J. Taylor, M.D., clinical spokesperson for the American Academy of Ophthalmology. We encourage women as well as men to get regular eye care. By making vision a priority today, we can help protect our sight as we age.

We know that women in the CNMI drive most of their familys healthcare decisions. They are often the leaders in their families, said Russ Quinn, CEO of Marianas Eye Institute. Yet the statistics clearly show that women are at higher risk for eye disease, and we encourage them all the CNMIs women to make sure their own care receives priority, he said.

To learn more ways to keep your eyes healthy, visit the Marianas Eye Institute website.

Marianas Eye Institute is known as a regional leader in eye care, providing total eye care for the family, including express glasses, contact lenses, medical eye care, surgery and laser. Marianas Eye Institute is staffed by Dr. Dennis Williams, who has been listed in Americas Top Ophthalmologists, and Dr. Mark Robertson, a magna cum laude optometrist, along with eight other highly talented and nationally certified eye care ophthalmic technicians, opticians, and contact lens technicians. Located on Beach Road in Garapan, across 13 Fishermen Monument, Marianas Eye Institute is open Monday through Saturday and accepts new patients as well as walk-ins. Anyone interested in womens eye health can call 235-9090.

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Women face higher risk of blindness than men - Marianas Variety

Barron's

ETF Flopper: Biotechnology and Pharmaceuticals Feel the Pain Barron's Meanwhile the SPDR S&P Biotech ETF (XBI), the SPDR S&P Pharmaceuticals ETF (XPH), and the First Trust NYSE Arca Biotechnology Index (FBT) fell about 2.7% apiece. The AHCA could have both positive and negative impact on pharma and biotech, but ...

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ETF Flopper: Biotechnology and Pharmaceuticals Feel the Pain - Barron's

Puma Biotechnology Inc.s stock took a dive last week after its regulatory executive resigned less than three weeks before a U.S. Food and Drug Administration panel is scheduled to review the public companys breast cancer drug Neratinib.

The Westwood companys share price dipped 14 percent to $31.38 at the close of business May 5 from $36.45 the day before, when the company notified the Securities and Exchange Commission that Robert Charnas, senior vice president of regulatory affairs and project management, would step down for health reasons effective May 15.

The stock was trading at $29.15 when the markets closed Monday.

The company, which has a market cap of $1.07 billion, hired 63-year-old Charnas last year with a base salary of more than $330,000, stock options, and a more than $378,000 signing bonus, according to the employment offer letter filed with the SEC.

An independent panel of experts is scheduled to review Neratinib for safety and efficacy May 24 before making a recommendation for its use to the FDA.

Caroline Anderson is a staff reporter covering retail, restaurants, and hospitality. She can be reached at canderson@labusinessjournal.com.

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Puma Biotechnology Stock Slumps as Regulatory VP Departs Before FDA Review - Los Angeles Business Journal

This report describes and evaluates animal biotechnology and its application in veterinary medicine and pharmaceuticals as well as improvement in food production. Knowledge of animal genetics is important in the application of biotechnology to manage genetic disorders and improve animal breeding. Genomics, proteomics and bioinformatics are also being applied to animal biotechnology.

Transgenic technologies are used for improving milk production and the meat in farm animals as well as for creating models of human diseases. Transgenic animals are used for the production of proteins for human medical use. Biotechnology is applied to facilitate xenotransplantation from animals to humans. Genetic engineering is done in farm animals and nuclear transfer technology has become an important and preferred method for cloning animals.There is discussion of in vitro meat production by culture.

Biotechnology has potential applications in the management of several animal diseases such as foot-and-mouth disease, classical swine fever, avian flu and bovine spongiform encephalopathy. The most important biotechnology-based products consist of vaccines, particularly genetically engineered or DNA vaccines. Gene therapy for diseases of pet animals is a fast developing area because many of the technologies used in clinical trials humans were developed in animals and many of the diseases of cats and dogs are similar to those in humans.RNA interference technology is now being applied for research in veterinary medicine.

Molecular diagnosis is assuming an important place in veterinary practice. Polymerase chain reaction and its modifications are considered to be important. Fluorescent in situ hybridization and enzyme-linked immunosorbent assays are also widely used. Newer biochip-based technologies and biosensors are also finding their way in veterinary diagnostics.

Approximately 124 companies have been identified to be involved in animal biotechnology and are profiled in the report. These are a mix of animal healthcare companies and biotechnology companies. Top companies in this area are identified and ranked. Information is given about the research activities of 11 veterinary and livestock research institutes. Important 108 collaborations in this area are shown.

Share of biotechnology-based products and services in 2016 is analyzed and the market is projected to 2026.

The text is supplemented with 35 tables and 5 figures.Selected 260 references from the literature are appended.

Key Topics Covered:

Executive Summary

1. Introduction to Animal Biotechnology

2. Application of Biotechnology in Animals

3. A Biotechnology Perspective of Animals Diseases

4. Molecular Diagnostics in Animals

5. Biotechnology-based Veterinary Medicine

6. Research in Animal Biotechnology

7. Animal Biotechnology Markets

8. Regulatory issues

9. Companies Involved in Animal Biotechnology

10. References

For more information about this report visit http://www.researchandmarkets.com/research/mdr33b/animal

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To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/animal-biotechnology-technologies-markets-and-companies-2016-2026-with-profiles-of-the-top-companies---research-and-markets-300452977.html

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Animal Biotechnology Technologies, Markets and Companies 2016 ... - PR Newswire (press release)