SALT LAKE CITY, May 08, 2023 (GLOBE NEWSWIRE) -- Myriad Genetics, Inc., (NASDAQ: MYGN), a leader in genetic testing and precision medicine, today announced it has achieved the Great Place to Work® certification for 2023.
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Myriad Genetics Earns 2023 Great Place to Work Certification™
SAN DIEGO, May 08, 2023 (GLOBE NEWSWIRE) -- Adamis Pharmaceuticals Corporation (NASDAQ: ADMP), a commercial-stage biopharmaceutical company primarily focused on developing and commercializing products in various therapeutic areas, including opioid overdose, allergy, respiratory and inflammatory disease, today announced that it will host an investor conference call on Monday, May 15, 2023 at 2:00 p.m. Pacific Time to discuss its financial and operating results for the first quarter 2023 as well as provide a corporate update, which may include an update concerning the results of the company’s special meeting of stockholders scheduled to be held on May 15, 2023 at 10:00 a.m. Pacific Time as well as the proposals to be considered and acted upon at the meeting. The company’s first quarter 2023 financial results news release is expected to be available after 1:00 p.m. Pacific Time on May 15, 2023, and on its website.
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Adamis Pharmaceuticals Schedules First Quarter 2023 Financial Results Conference Call and Corporate Update
SAN DIEGO, May 08, 2023 (GLOBE NEWSWIRE) -- BioAtla, Inc. (Nasdaq: BCAB), a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics for the treatment of solid tumors, today announced that the Company’s management will provide a corporate update and participate in one-on-one investor meetings at the JMP Securities Life Sciences Conference, to be held in New York, NY, from May 15-16, 2023.
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BioAtla to Participate in the JMP Securities Life Sciences Conference
Q1 2023 revenue $21.4 million, 27% y/y growth Reiterating FY 2023 revenue guidance range of $95-98 million
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Akoya Reports Record Revenue in the First Quarter of 2023 and Reiterates Full Year 2023 Revenue Guidance
Reiterates 2023 Financial Guidance Reiterates 2023 Financial Guidance
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Certara Reports First Quarter 2023 Financial Results
MALVERN, Pa., May 08, 2023 (GLOBE NEWSWIRE) -- TELA Bio, Inc. ("TELA Bio") (NASDAQ: TELA), a commercial-stage medical technology company focused on providing innovative soft-tissue reconstruction solutions that optimize clinical outcomes by prioritizing the preservation and restoration of the patient's own anatomy, today announced that the Compensation Committee of the Board of Directors of TELA Bio approved inducement grants of restricted stock units covering 27,250 shares of its common stock to seventeen newly-hired employees, with a grant date of May 5, 2023 (the "Grant Date"). The restricted stock units were granted pursuant to the Nasdaq Rule 5635(c)(4) inducement grant exception as a component of each individual's employment compensation and were granted as an inducement material to his or her acceptance of employment with TELA Bio.
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Hypoimmune-modified allogeneic iPSCs evade immune response and rejection without immunosuppression in non-human primate model
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Sana Biotechnology Announces Preclinical Data Published in Nature Biotechnology Demonstrating its Hypoimmune-Engineered Cells Escape Immune Detection...
First patient dosed in Quoin’s single arm, open label clinical trial in Netherton Syndrome patients currently receiving off-label systemic therapy
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Quoin Pharmaceuticals Provides Corporate Update and Announces First Quarter 2023 Financial Results
From fear to freedom: Anchor Paul LaGrone shares his story of sudden hair loss & the disease that caused it ABC Action News Tampa Bay
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From fear to freedom: Anchor Paul LaGrone shares his story of sudden hair loss & the disease that caused it - ABC Action News Tampa Bay
Biotechnology has numerous applications, particularly in medicine and agriculture. Examples include the use of biotechnology in merging biological information with computer technology (bioinformatics), exploring the use of microscopic equipment that can enter the human body (nanotechnology), and possibly applying techniques of stem cell research and cloning to replace dead or defective cells and tissues (regenerative medicine). Companies and academic laboratories integrate these disparate technologies in an effort to analyze downward into molecules and also to synthesize upward from molecular biology toward chemical pathways, tissues, and organs.
In addition to being used in health care, biotechnology has proved helpful in refining industrial processes through the discovery and production of biological enzymes that spark chemical reactions (catalysts); for environmental cleanup, with enzymes that digest contaminants into harmless chemicals and then die after consuming the available food supply; and in agricultural production through genetic engineering.
Agricultural applications of biotechnology have proved the most controversial. Some activists and consumer groups have called for bans on genetically modified organisms (GMOs) or for labeling laws to inform consumers of the growing presence of GMOs in the food supply. In the United States, the introduction of GMOs into agriculture began in 1993, when the FDA approved bovine somatotropin (BST), a growth hormone that boosts milk production in dairy cows. The next year, the FDA approved the first genetically modified whole food, a tomato engineered for a longer shelf life. Since then, regulatory approval in the United States, Europe, and elsewhere has been won by dozens of agricultural GMOs, including crops that produce their own pesticides and crops that survive the application of specific herbicides used to kill weeds.
Studies by the United Nations, the U.S. National Academy of Sciences, the European Union, the American Medical Association, U.S. regulatory agencies, and other organizations have found GMO foods to be safe, but skeptics contend that it is still too early to judge the long-term health and ecological effects of such crops. In the late 20th and early 21st centuries, the land area planted in genetically modified crops increased dramatically, from 1.7 million hectares (4.2 million acres) in 1996 to 180 million hectares (445 million acres) by 2014. By 201415 about 90 percent of the corn, cotton, and soybeans planted in the United States were genetically modified. The majority of genetically modified crops were grown in the Americas.
Overall, the revenues of U.S. and European biotechnology industries roughly doubled over the five-year period from 1996 through 2000. Rapid growth continued into the 21st century, fueled by the introduction of new products, particularly in health care. By 2020 the biotechnology market size was estimated at $752.88 billion globally, with new opportunities for growth emerging in particular from government- and industry-driven efforts to accelerate drug development and product-approval processes.
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Where Does BioLine RX Ltd - ADR (BLRX) Stock Fall in the Biotechnology Field After It Is Down -3.67% This Week? InvestorsObserver
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Where Does BioLine RX Ltd - ADR (BLRX) Stock Fall in the Biotechnology Field After It Is Down -3.67% This Week? - InvestorsObserver
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OverviewPeripheral neuropathy can affect nerves anywhere in your body. It can disrupt your bodys control of automatic processes, as well as your sense of touch and muscle control.What is peripheral neuropathy?
Peripheral neuropathy is an umbrella term for nerve diseases that affect a specific subdivision of your nervous system. Many different conditions can cause peripheral neuropathy, which means a wide range of symptoms is also possible. Peripheral neuropathy can also affect different body parts, depending on how and why it happens.
The term peripheral is from the Greek word that means around. Peripheral in this context means outside of or away from the central nervous system. The term neuropathy combines two words that trace their origins back to ancient Greek:
Your nervous system has two parts, the central nervous system and the peripheral nervous system. Your brain and spinal cord are the two components that make up your central nervous system. Your peripheral nervous system consists of all the other nerves in your body. It also includes nerves that travel from your spinal cord and brain to supply your face and the rest of your body.
Peripheral neuropathy can refer to any condition affecting your peripheral nerves. Healthcare providers often use the terms neuropathy and polyneuropathy (meaning disease of many nerves) interchangeably with peripheral neuropathy. Peripheral nerves are farthest from the central nervous system, and they often show the earliest and most severe effects of these conditions
Peripheral neuropathy can affect anyone, regardless of age, sex, race or ethnicity, personal circumstances, medical history, etc. However, some people are at greater risk for specific types of peripheral neuropathy (see below under Causes and Symptoms for more about this).
Peripheral neuropathy is also very common with some age-related diseases. That means the risk of developing peripheral neuropathy increases as you get older.
Peripheral neuropathy is common, partly because this term refers to so many conditions. About 2.4% of people globally have a form of peripheral neuropathy. Among people 45 and older, that percentage rises to between 5% and 7%.
To understand how peripheral neuropathy affects your body, it helps to know a little about the structure of neurons, a key type of cell that makes up your nerves. Neurons send and relay signals through your nervous system using electrical and chemical signals. Each neuron consists of the following:
Peripheral neuropathy happens in two main ways:
How peripheral neuropathy develops, particularly the timeline of its progress, depends very much on what causes it. Injuries can cause it to develop instantaneously or within minutes or hours. Some toxic and inflammation-based forms of peripheral neuropathy may develop rapidly over days or weeks, while most other conditions take months, years or even decades to develop.
There are many different symptoms of peripheral neuropathy. This condition can affect a single nerve, a connected group of related nerves, or many nerves in multiple places throughout your body. The symptoms also depend on the type of nerve signals affected, and multiple signal types may be involved.
The symptom types (with more about them below) are:
Your peripheral nervous system carries motor signals, which are commands sent from your brain to your muscles. These signals are what make it possible for you to move around. Your muscles need nerve connections to the brain to stay healthy and work properly.
Motor symptoms include:
Your peripheral nerves convert information about the outside world into nerve signals. Those signals then travel to your brain, which processes those signals into what you can sense of the world around you. Peripheral neuropathy can disrupt what your senses pick up from the outside world or the ability of those senses to communicate with your brain.
The sensory symptoms of peripheral neuropathy include:
Your body has several autonomic processes. These are the automatic functions of your body that happen without your thinking or even being aware of them. They include things like sweating, digestion, blood pressure control, etc. Autonomic nerve fibers carry autonomic signals. Disruptions in autonomic signals mean your bodys automatic processes cant work correctly. Some may work off and on, while others may not work at all.
Autonomic symptoms of peripheral neuropathy can include:
Peripheral neuropathy can happen for many reasons. These include:
Peripheral neuropathy isnt contagious. While it can happen because of infectious diseases, this condition doesnt spread from person to person on its own. The only exception is Hansen disease, which can spread from person to person but doesnt spread easily.
Diagnosing peripheral neuropathy usually involves a combination of methods. These include:
The most common types of tests for peripheral neuropathy (either to confirm the diagnosis or rule out other conditions) include:
The treatment for peripheral neuropathy can vary widely depending on its cause. Other factors can also affect treatment, including your medical history, personal preferences and more. Your healthcare provider is the best person to tell you more about the treatment(s) they recommend and the likely recovery timeline. In general, the following treatment methods are more common for peripheral neuropathy:
The possible side effects and complications of treatments for peripheral neuropathy depend on many factors. These include the specific cause of the neuropathy, other conditions you have, the specific treatments you receive and more. Your healthcare provider is the best person to tell you more about the possible side effects and complications you might experience.
Peripheral neuropathy is a sign of a problem with the nerve signals traveling between parts of your body and your brain. While this can happen for minor reasons that arent serious, it can also happen because of severe or dangerous conditions. Its also sometimes possible to stop or reverse certain types of neuropathies if treatment begins quickly enough. Because of these factors, you shouldnt try to self-diagnose and self-treat it. A healthcare provider is the best person to guide you in managing this condition.
Some of the possible causes of peripheral neuropathy are preventable. You can also lower your chances of developing it by preventing or delaying certain conditions. In general, the best preventive or precautionary steps you can take include:
The effects of peripheral neuropathy depend on the cause, the nerves it affects, your medical history, treatments you receive and more. Your healthcare provider is the best person to tell you more about what you can expect in your case.
Peripheral neuropathy can be a temporary concern, or it can be permanent. How long it lasts depends on what caused it, the extent of the damage if any that it caused, the treatments and more.
Peripheral neuropathy is most likely to be permanent with chronic conditions like type 2 diabetes, autoimmune diseases and genetic conditions. However, this can still vary, so its best to ask your healthcare provider about whats most likely in your case.
Peripheral neuropathy is usually not dangerous, but it can have very disruptive effects on your life. These effects are usually not as severe when it only affects one nerve or a limited group of nerves. The more nerves it affects, the greater the potential impact.
The outlook also depends partly on your symptoms. Pain from peripheral neuropathy is usually the most disruptive symptom, but medications or other treatments may help. Autonomic symptoms are among the most serious because they involve your bodys vital functions. When those dont work correctly, it can have very severe and sometimes dangerous effects.
Motor and sensory symptoms can also greatly disrupt your ability to work and go about your daily activities. They can cause problems sometimes severe with mobility, balance and coordination. Sensory symptoms are also disruptive, especially when they involve pain or affect your ability to control what you do with the affected body part(s).
Lastly, treatments can make a big difference in outlook. Some treatments can greatly reduce or even stop symptoms, but this varies. Your healthcare provider is the best source of information on the outlook for your case and what you can do to help.
If you have peripheral neuropathy, its important to follow your healthcare providers guidance. That includes seeing them as recommended, taking medications or treatments as prescribed and modifying your life to protect yourself and manage your symptoms. The actions you can take also vary widely depending on many factors, and what helps one person may not be as effective for another.
If you have symptoms of peripheral neuropathy, you should see a healthcare provider as soon as possible. In some cases, peripheral neuropathy symptoms start before the condition causes permanent changes or damage, so it may be possible to limit the effects or even reverse them.
If you receive a diagnosis of peripheral neuropathy, you should see your healthcare provider as recommended or if you notice changes in your symptoms. You should also talk to them if you experience side effects from any treatments. Talking to your healthcare provider can be especially helpful when you have symptom changes or side effects that affect your usual routine and activities. Your provider may be able to modify your treatment or find ways to adapt to these changes and limit their effects.
In general, peripheral neuropathy isnt likely to cause life-threatening complications or symptoms. However, there are a few conditions that fall under peripheral neuropathy that are severe and need immediate medical attention.
There are also conditions that share symptoms with peripheral neuropathy. You should go to the ER if you have symptoms of certain conditions that can be especially dangerous, such as:
You should also go to the ER if you have autonomic symptoms of peripheral neuropathy, such as:
Peripheral neuropathy may be reversible in some cases, but many factors influence whether or not this is possible. Because there are so many factors involved, your healthcare provider should be the one to answer this question for you. The information they provide will be the most accurate and relevant for your specific case and circumstances.
Fatigue is a symptom that can happen with conditions that can cause peripheral neuropathy. It can also happen due to living with severe or long-term pain due to peripheral neuropathy, or because of autonomic problems from peripheral neuropathy. However, it isnt a direct symptom of peripheral neuropathy itself.
Peripheral neuropathy can be serious, but there are many reasons why it might not be. Whether or not its serious depends on many factors, including the symptoms it causes, how severely it affects nerves and more. Your healthcare provider is the best person to tell you about the seriousness of your case and what that means for you.
Peripheral neuropathy isnt something you can self-diagnose. A qualified and trained healthcare provider can diagnose it, but the diagnosis process almost always involves some form of diagnostic, imaging or laboratory testing. You may suspect you have peripheral neuropathy based on the symptoms you experience, but you should see a healthcare provider to be sure.
Theres no one common treatment for peripheral neuropathy. The treatments depend on whats causing it and the symptoms you experience. Some causes of peripheral neuropathy are directly treatable. For others, treating and minimizing the symptoms and their effects is the best approach.
Yes, peripheral neuropathy can sometimes go away, but this isnt universal. Many factors can influence how long peripheral neuropathy lasts. The condition that causes peripheral neuropathy is a major factor in whether or not it will go away, as are the treatments you receive. Its also important to remember that what works for one person may not work for another, because peripheral neuropathy can happen very differently from person to person.
A note from Cleveland Clinic
Peripheral neuropathy is an umbrella term for any condition, disease or disorder that affects your peripheral nerves, which are all the nerves outside of your spinal cord and brain. There are many different ways that peripheral neuropathy can happen, so this condition is common.
For some people, peripheral neuropathy is temporary, treatable or both. For others, its permanent and incurable. Thanks to advances in medical science and technology, many symptoms or forms of peripheral neuropathy are now treatable. That offers many people a chance to manage this condition, meaning they can live longer and with fewer restrictions or impacts from the related conditions and symptoms.
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Peripheral Neuropathy: What It Is, Symptoms & Treatment - Cleveland Clinic
What is peripheral neuropathy?
Peripheral neuropathy refers to the many conditions that involve damage to the peripheral nervous system, which is a vast communications network that sends signals between the central nervous system (the brain and spinal cord) and all other parts of the body.
Peripheral nerves send many types of sensory information to the central nervous system (CNS), such as the message that your feet are cold. They also carry signals from the CNS to the rest of the body. Best known are the signals to the muscles that tell them to contract, which is how we move, but there are different types of signals that help control everything from our heart and blood vessels, digestion, urination and sexual function to our bones and immune system.
More than 20 million people in the U.S. are estimated to have some form of peripheral neuropathy, but this figure may be significantly higher as not all people with symptoms of neuropathy are tested for the disease and tests currently do not look for all forms of neuropathy.
Nerve signal interruption
The peripheral nerves are like cables that connect different parts of a computer or connect to the Internet. When they malfunction, complex functions can grind to a halt.
Nerve signaling in neuropathy is disrupted in three ways:
Some forms of neuropathy involve damage to only one nerve (mononeuropathy). Neuropathy affecting two or more nerves in different areas is called multiple mononeuropathy or mononeuropathy multiplex. More often, many or most of the nerves are affected (polyneuropathy).
Classifying the nerves and peripheral neuropathies
More than 100 types of peripheral neuropathy have been identified, each with its own symptoms and prognosis. Symptoms vary depending on the type of nervesmotor, sensory, or autonomicthat are damaged.
Most neuropathies affect all three types of nerve fibers to varying degrees; others primarily affect one or two types. Doctors use terms such as predominantly motor neuropathy, predominantly sensory neuropathy, sensory-motor neuropathy, or autonomic neuropathy to describe different conditions.
About 75 percent of polyneuropathies are length-dependent, meaning the farthest nerve endings in the feet are where the symptoms develop first or are worse. In severe cases, these neuropathies can spread upwards toward the central parts of the body. In non-length dependent polyneuropathies, the symptoms can start around the torso, or are patchy.
Symptoms
Symptoms can range from mild to disabling, but are rarely life-threatening. The symptoms depend on the type of nerve fibers affected and the type and severity of damage. Symptoms may develop over days, weeks, or years. In some cases, symptoms improve on their own and may not require advanced care. Unlike nerve cells in the CNS, peripheral nerve cells continue to grow throughout life.
Symptoms are related to the type of nerves affected.
Motor nerve damage is most commonly associated with muscle weakness. Other symptoms include:
Sensory nerve damage causes various symptoms because sensory nerves have a broad range of functions.
Autonomic nerve damage affects the axons in small-fiber neuropathies. Common symptoms include:
Types of peripheral neuropathy
There are several types of peripheral neuropathies, including
Most instances of neuropathy are either acquired, meaning the neuropathy or the inevitability of getting it isn't present from the beginning of life, or genetic. Acquired neuropathies are either symptomatic (the result of another disorder or condition) or idiopathic (meaning it has no known cause).
Acquired peripheral neuropathy causes include:
Genetically caused polyneuropathies are rare. Genetic mutations can either be inherited or arise "de novo," meaning they are completely new to an individual and are not present in either parent. Some genetic mutations lead to mild neuropathies with symptoms that begin in early adulthood and result in little, if any, significant impairment. More severe hereditary neuropathies often appear in infancy or childhood. The small-fiber neuropathies that present with pain, itch, and autonomic symptoms can be genetic.
Diagnosing peripheral neuropathy
The variability of symptoms that neuropathies can cause often makes diagnosis difficult. A diagnosis of neuropathy can include:
Additional tests may be ordered to help determine the nature and extent of the neuropathy.
Physiologic tests of nerve function
Neuropathology tests of nerve appearance
Autonomic testing
Radiology imaging tests
Muscle and nerve ultrasound is a noninvasive experimental technique for imaging nerves and muscles for injury such as a severed nerve or a compressed nerve. Ultrasound imaging of the muscles can detect abnormalities that may be related to a muscle or nerve disorder. Certain inherited muscle disorders have characteristic patterns on muscle ultrasound.
Treating peripheral neuropathy
Treatments depend entirely on the type of nerve damage, symptoms, and location. Your doctor will explain how nerve damage is causing your specific symptoms and how to minimize and manage them. You may be able to reduce your medication dose or manage your neuropathy without medications. Definitive treatment can allow for functional recovery over time, as long as the nerve cell itself has not died.
Correcting underlying causes can result in the neuropathy resolving on its own as the nerves recover or regenerate. Nerve health and resistance can be improved by healthy lifestyle habits such as maintaining optimal weight, avoiding toxic exposures, eating a balanced diet, and correcting vitamin deficiencies.
Smoking constricts the blood vessels that supply nutrients to the peripheral nerves and can worsen neuropathic symptoms. Exercise can deliver more blood, oxygen, and nutrients to far-off nerve endings, improve muscle strength, and limit muscle atrophy. Self-care skills in people with diabetes and others who have an impaired ability to feel pain can alleviate symptoms and often create conditions that encourage nerve regeneration. Strict control of blood glucose levels can reduce neuropathic symptoms and help people with diabetic neuropathy avoid further nerve damage.
Inflammatory and autoimmune conditions leading to neuropathy can be controlled using immunosuppressive drugs such as prednisone, cyclosporine, or azathioprine. Plasmapheresisa procedure in which blood is removed, cleansed of immune system cells and antibodies, and then returned to the bodycan help reduce inflammation or suppress immune system activity. Agents such as rituximab that target specific inflammatory cells, large intravenously administered doses of immunoglobulins, and antibodies that alter the immune system, also can suppress abnormal immune system activity.
Improving symptoms
Medications recommended for chronic neuropathic pain are also used for other medical conditions. Among the most effective are a class of drugs first marketed to treat depression. Nortriptyline and newer serotonin-norepinephrine reuptake inhibitors such as duloxetine hydrochloride modulate pain by increasing the brain's ability to inhibit incoming pain signals.
Another class of medications that quiets nerve cell electrical signaling is also used for epilepsy. Common drugs include gabapentin, pregabalin, and less often topiramate and lamotrigine. Carbamazepine and oxcarbazepine are particularly effective for trigeminal neuralgia, a focal neuropathy of the face.
Local anesthetics and related drugs that block nerve conduction may help when other medications are ineffective or poorly tolerated. Medications put on the skin (topically administered) are generally appealing because they stay near the skin and have fewer unwanted side effects. Lidocaine patches or creams applied to the skin can be helpful for small painful areas, such as localized chronic pain from mononeuropathies such as shingles. Another topical cream is capsaicin, a substance found in hot peppers that can desensitize peripheral pain nerve endings.Doctor-applied patches that contain higher concentrations of capsaicin offer longer term relief from neuropathic pain and itching, but they worsen small-fiber nerve damage.Weak over-the-counter formulations also are available. Lidocaine or longer acting bupivacaine are sometimes given using implanted pumps that deliver tiny quantities to the fluid that bathes the spinal cord, where they can quiet excess firing of pain cells without affecting the rest of the body. Other drugs treat chronic painful neuropathies by calming excess signaling.
Narcotics (opioids) can be used for pain that doesn't respond to other pain-control medications and if disease-improving treatments aren't fully effective. Because pain relievers that contain opioids can lead to dependence and addiction, their use must be closely monitored by a physician. One of the newest drugs approved for treating diabetic neuropathy is tapentadol, which has both opioid activity and norepinephrine-reuptake inhibition activity of an antidepressant.
Surgery is the recommended treatment for some types of neuropathies. Protruding disks (pinched nerve) in the back or neck that compress nerve roots are commonly treated surgically to free the affected nerve root and allow it to heal. Injuries to a single nerve (mononeuropathy) caused by compression, entrapment, or rarely tumors or infections may require surgery to release the nerve compression. Polyneuropathies that involve more scattered nerve damage, such as diabetic neuropathy, are not helped by surgical intervention. Surgeries or interventional procedures that attempt to reduce pain by cutting or injuring nerves are not often effective as they worsen nerve damage and the parts of the peripheral and central nervous system above the cut often continue to generate pain signals (phantom pain). More sophisticated and less damaging procedures such as electrically stimulating remaining peripheral nerve fibers or pain-processing areas of the spinal cord or brain have largely replaced these surgeries.
Transcutaneous electrical nerve stimulation (TENS) is a noninvasive intervention used for pain relief in a range of conditions. TENS involves attaching electrodes to the skin at the site of pain or near associated nerves and then administering a gentle electrical current. Although data from controlled clinical trials are not available to broadly establish its efficacy for peripheral neuropathies, in some studies TENS has been shown to improve neuropathic symptoms associated with diabetes.
Prevention
The best treatment is prevention, and strategies for reducing injuries are highly effective and well tested. Since medical procedures ranging from casting fractures to injuries from needles and surgery are another cause, unnecessary procedures should be avoided.
The new adjuvanted vaccine (anadjuvantis an ingredient used in some vaccines that helps create a stronger immune response in people receiving the vaccine)against shingles prevents more than 95 percent of cases and is widely recommended for people over 50, including those who have had previous shingles or vaccination with the older, less effective vaccine.
Diabetes and some other diseases are common preventable causes of neuropathy. People with neuropathy should ask their doctors to minimize use of medications that are known to cause or worsen neuropathy where alternatives exist. Some families with very severe genetic neuropathies use in vitro fertilization (IVF) to prevent transmission to future generations.
The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. NINDS is a component of the National Institutes of Health (NIH), a leading supporter of biomedical research in the world.
NINDS-funded research ranges from clinical studies of the genetics and the natural history of hereditary neuropathies to discoveries of new cause and treatments for neuropathy, to basic science investigations of the biological mechanisms responsible for chronic neuropathic pain. Together, these diverse research areas will advance the development of new therapeutic and preventive strategies for peripheral neuropathies. Understanding the causes of neuropathy provides the foundation for finding effective prevention and treatment strategies.
Genetic mutations have been identified in more than 80 distinct hereditary neuropathies. NINDS supports studies to understand the disease mechanisms of these conditions and to identify other genetic defects that may play roles in causing or modifying the course of disease. The Inherited Neuropathies Consortium (INC)a group of academic medical centers, patient support organizations, and clinical research resources dedicated to conducting clinical research in Charcot-Marie-Tooth disease and improving the care of people with the diseaseis working to characterize the natural history of several different forms of neuropathy and to identify genes that modify clinical features in these disorders. Knowing which genes are mutated, and what their normal function is, allows precise diagnosis and leads to new therapies that can prevent or reduce nerve damage. INC is also developing and testing biomarkers (signs that can indicate the diagnosis or progression of a disease) and clinical outcome measures that will be needed in future clinical trials to determine whether individuals respond to candidate treatments.
Rapid communication between the peripheral nervous system and the central nervous system often depends on myelination, a process through which special cells called Schwann cells create an insulating coating around axons. Several NINDS-funded studies focus on understanding how myelin protein and membrane production and maintenance in Schwann cells is regulated and how mutations in genes involved in these processes cause peripheral neuropathies. Schwann cells play a critical role in the regeneration of nerve cell axons in the peripheral nervous system. By better understanding myelination and Schwann cell function, researchers hope to find targets for new therapies to treat or prevent nerve damage associated with neuropathy.
In inflammatory peripheral neuropathies such as Guillain-Barr syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP), the body's immune system mistakenly attacks peripheral nerves, damaging myelin and weakening signaling along affected nerves. NINDS-supported researchers hope to better understand how antibodies to cell membrane components cause peripheral nerve damage and how the effects of these antibodies can be blocked. Researchers are also studying how mutations in the Autoimmune Regulator (AIRE) gene in a mouse model of CIDP cause the immune system to attack peripheral nerves. NINDS research has helped discover that some types of small-fiber polyneuropathy appear to be immune-caused, particularly in women and children.
NINDS-supported researchers are also exploring the use of tissue engineered from the cells of humans with peripheral neuropathy as models to identify specific defects in the transport of cellular components along axons and the interactions of nerves with muscles. Such tissue engineering approaches may eventually lead to new therapeutics for peripheral neuropathies.
In addition to efforts to treat or prevent underlying nerve damage, other NINDS-supported studies are informing new strategies for relieving neuropathic pain, fatigue, and other neuropathy symptoms. Researchers are investigating the pathways that carry pain signals to the brain and are working to identify substances that will block this signaling.
For research articles and summaries on peripheral neuropathy, search PubMed, which contains citations from medical journals and other sites.
Learn About Clinical Trials
Clinical trials are studies that allow us to learn more about disorders and improve care. They can help connect patients with new and upcoming treatment options.
Consider participating in a clinical trial so clinicians and scientists can learn more about peripheral neuropathy and other nerve disorders. Clinical research uses human volunteers to help researchers learn more about a disorder and perhaps find better ways to safely detect, treat, or prevent disease.
All types of volunteers are neededthose who are healthy or may have an illness or diseaseof all different ages, sexes, races, and ethnicities to ensure that study results apply to as many people as possible, and that treatments will be safe and effective for everyone who will use them.
For information about participating in clinical research visit NIH Clinical Research Trials and You. Learn about clinical trials currently looking for people with peripheral neuropathy at Clinicaltrials.gov, a database of current and past trials, some of which have research results.
Information and resources on peripheral neuropathy and nerve disease are available from the following organizations:
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Ionis Pharmaceuticals - Eplontersen halted ATTRv-PN disease progression and improved neuropathy impairment and quality of life in Phase 3 study through 66 weeks Marketscreener.com
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Ionis Pharmaceuticals - Eplontersen halted ATTRv-PN disease progression and improved neuropathy impairment and quality of life in Phase 3 study...
Successfully Treating Diabetic Neuropathy at Vero Neuropathy | Paid Content Local 5 - weareiowa.com
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Peripheral Neuropathy Treatment at Advanced Nerve and Health Center WFAA.com
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COUNTY COLUMN: Learn to Live well with diabetes at The Well Norman Transcript
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