StemCell Therapy

Scientists are making use of discarded animal organs by turning them into origami but its more than just an art project.

A team of researchers at Northwestern University created the paper cranes to demonstrate the flexibility and malleability of their latest breakthrough: a tissue paper that has the potential to heal wounds, prevent scarring and help hormone production in cancer patients.

This new class of biomaterials has potential for tissue engineering and regenerative medicine as well as drug discovery and therapeutics, Ramille Shah, one of the team members, told Northwestern.edu. Its versatile and surgically friendly.

The tissue paper is a blend of proteins from animal organs that, when wet, can be folded, rolled, cut, flattened, balled, ripped and even crafted into tiny birds. It can also be frozen for later use, making it even more practical.

In one of the first lab tests, the team successfully grew hormone-secreting follicles in a culture using a paper made from a cow ovary. Their findings were recently published in Advanced Functional Materials.

And as with many scientific discoveries, the team at Northwestern stumbled upon the new material as an accident.

The scientists were researching 3D-printed mice ovaries when one of the team members spilled the hydrogel-based gelatin ink used in creating the ovaries. The ink pooled into a dry sheet that ended up being surprisingly strong.

The light bulb went on in my head, Adam Jakus, another one of the team members, told Northwestern.edu. I knew right then I could make large amounts of bioactive materials from other organs.

Since then, the researchers have been collecting scrap pig and cow organs from a local butcher and using them to further test out the regenerative tissue paper.

Breaking down everything from animal uteruses to kidneys to muscles to hearts, the team extracts the structural proteins which give an organ its form then dries them out and combines it was a polymer, or resin, which generates the thin, paper structure.

The final product is basically a papier-mch-like sheet of proteins that can retain the biochemicals needed to regenerate a sick or injured piece of tissue, like a human liver, or skin laceration.

Though a lot more research is needed, the material could one day be used to accelerate healing after surgery and help treat hormone deficiencies in cancer patients. The researchers also found it can support human stem cell growth.

It is really amazing that meat and animal by-products like a kidney, liver, heart and uterus can be transformed into paper-like biomaterials that can potentially regenerate and restore function to tissues and organs, Jakus said. Ill never look at a steak or pork tenderloin the same way again.

Read more:
'Origami organs' could be the future of regenerative medicine - New York Post

This entry was posted on August 10, 2017 at 2:44 pm and is filed under Regenerative Medicine. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |