StemCell Therapy

While its undeniable that logging miles has major health benefits, scientists dont exactly understand how it affects your body at the molecular levelbut researchers are attempting to figure that out.

A Stanford University study published in Cell set out to determine what happens in the body just after exercise, and try to get one step closer to explaining exactly what makes exercise so good for your health.

In the study, 36 people aged 40 to 75 completed a peak VO2 testwhich measures maximum oxygen consumption during intense exercise as a marker of aerobic fitnesson a treadmill. Before running, researchers sampled their blood. Then, after about 9 to 10 minutes of running, the participants blood was sampled multiple times: immediately after exercise, and then 15, 30, and 60 minutes after they reached their peaks.

Researchers then completed multi-omic profiling, where they looked at the participants blood to see how exercise affected molecular changes in the cellsincluding how exercise affects immune cells and plasma. Over 17,000 molecules were measured, and 9,815 moleculesmore than halfshowed significant change, Michael Snyder, Ph.D., professor and chair of genetics at the Stanford University School of Medicine, in Stanford, California, told Runners World.

Exercise has a lot of health benefits, but nobody knows how exercise really works, Snyder said. Im not saying our study figured it out, but it gives us a window into whats going on in the body.

Researchers were able to see changes in oxidative stress, which is a harmful chemical process when theres too much of it. They also saw immune system markers and molecular markers of healing and inflammation go up right away as the body began to recover.

These results give a window into different systemic events, such as the potential to look into how oxidative stress affects aging, how exercise affects your immune system, how your body reacts to metabolic stresswhich occurs in exercise as energy depletes, leading to accumulation of lactic acid in musclesand how muscles are engaged during exercise as researchers work to further study the effects exercise has on the body.

I do view it as just trying to work out the choreography of whats going on, Snyder said. Its like a symphony, maybe the violins start off first, then the next instrument and the next come in.

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This kind of testing can give researchers the ability to see whats happening in peoples bodies, such as seeing how muscle markers and markers for cardiovascular disease are all stimulated and engaged.

While we know that exercise is important for heart health, its not exactly known how it benefits your ticker. This is something researchers hope to use these findings to study more in the future, Snyder said. And, while this test was only done using a treadmill stress test, researchers will look at how molecules in the body are affected by other types of exercise.

Results showed that peoples fitness and health levels were consistent with how much exercise affected the molecules in their bodies. For example, people that were healthy had similar molecular changes before and after exercise; those who were insulin resistant (prediabetic and diabetic) didnt have as large of an immune response, which may be able to show how exercise affects this condition or helps predict the onset of diabetes.

And, through these blood samples, the molecular patterns found anemia that other testing hadnt picked up in one healthy individual, Snyder said.

So what can this tell you about your health? Right now, researchers are still figuring that out. But as the molecules change, they are able to see things like how different systems in your body engage during exercise, how your cardiovascular pathways are affected, and when different types of fat burning may occur. All of these elements give researchers a better look at how exercise engages the entire body.

Were looking at the details of how the symphony is able to play, Snyder said.

In the future, the researchers hope that a version of molecular profiling can be used as a way to measure aerobic fitness and along with typical treadmill testing.

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One Run Can Alter 9,815 Molecules in Your BodyHeres Why Thats Important - runnersworld.com

This entry was posted on June 26, 2020 at 4:50 pm and is filed under Molecular Genetics. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |