Regenerative therapies such as stem cells and platelet-rich plasma already play an important role in managing osteoarthritis (OA). Nonetheless, veterinarians have found that response to even these therapies is less than ideal in many cases, prompting researchers to continuously seek novel therapies for this all-too-common musculoskeletal disorder. One of the newest to be unveiled is called bone marrow mononuclear cell (BMNC) therapy. One researcher who presented at the 2020 American Association of Equine Practitioners Convention, held virtually, reported that the equine industry is in critical need for therapies that resolve joint inflammation but preserve tissue healing, and BMNC appears a promising candidate.
Much more than stem cells classically sought for cartilage healing, bone marrow is rich in macrophage progenitor cells, explained James B. Everett, DVM, MS, previously of the Virginia-Maryland College of Veterinary Medicine, who now works at the Equine Surgical Center at ThorSport Farm,in Murfreesboro, Tennessee. Macrophages are a type of white blood cell that play a role in tissue repair and cartilage integrity, and produce the anti-inflammatory mediators, including interleukin-10 (IL-10).
Everett said macrophages in the synovial (joint) membrane are essential for joint health, clearing aggressors, secreting key molecules required for optimal joint function, and forming a shield that protects tissues undergoing repair, similar to a wound scab. However, when the amount of tissue damage overwhelms these housekeeping functions, macrophages stimulate inflammation as a means of recruiting more cells, especially more macrophages, to cope with increased demands for repair.
If this response is efficiently accomplished, macrophages then produce, among other things, high concentrations of IL-10 and resolve the inflammatory process, returning the joint to a healthy state, he said.
Everett emphasized that not all inflammation is bad. This acute inflammation is essential to establish a resolving response, and anti-inflammatory therapies can negatively interfere.
As presented by Everetts colleague Bruno Menarim, DVM, PhD, in a separate session, studies show that BMNCs promote the endogenous resolution of experimentally induced inflammation. To see if these promising features translated to naturally occurring inflammation in live horses, Everetts research team studied 19 horses, dividing them into three treatment groups:
The selected horses were diagnosed with OA in a single joint, and the team injected those joints once with the saline, triamcinolone, or BMNCs. The BMNCs were autologous, meaning veterinarians collected them from each patients own bone marrow aspirate. They processed the aspirate in-house, and the isolated mononuclear cells, composed predominantly of macrophages, were ready to inject into the affected joint within three hours of aspiration.
We found that while objectively assessed lameness (via Lameness Locator) decreased in all three groups, it was only significant in the BMNC-treated horses, said Everett. Further, the treatment was well-tolerated with no adverse events appreciated in this study.
He said that using BMNCs can help reduce the need for chronic use of non-steroidal anti-inflammatory drugs and corticosteroids, which produces potentially harmful consequences. Further, BMNCs preserve the production of molecules such as interleukins and cytokines that are essential for restoring joint homeostasis. Corticosteroids often inhibit these molecules.
The researchers noted that these results support a larger clinical trial using BMNCs in clinical cases of equine OA.
Read more:
Novel Bone Marrow 'Ingredient' To Help Arthritic Horses The Horse - TheHorse.com
- The Compression Fracture of Thoracic Spine Due to Methotrexate-Associated Lymphoproliferative Disorder in Rheumatoid Arthritis: A Case Report - Cureus - February 15th, 2025
- Rheumatoid arthritis tied to cognitive decline in dementia - Medical Xpress - February 15th, 2025
- Tools and Devices to Improve Life and Mobility With Arthritis - U.S. News & World Report - February 15th, 2025
- Actor Adam Thomas Reveals How 'Eating Nothing But Meat and Eggs' is Easing his Arthritis Pain But These Are the Risks - Men's Health UK - February 15th, 2025
- New insights into the association between arthritis and overactive bladder in NHANES 20052020 - Nature.com - February 15th, 2025
- Rheumatoid Arthritis Treatment Market to Hit US$ 79.1 Billion - openPR - February 15th, 2025
- Psoriatic Disease, TNF Inhibitors, and Risk of Major Adverse Events - Medpage Today - February 15th, 2025
- The best treatments for arthritic knees if you want to avoid knee replacement surgery - The Telegraph - February 15th, 2025
- Early Launch Metrics Indicate UCBs Bimzelx (bimekizumab) Poised to Disrupt the U.S. Psoriatic Arthritis Market - GlobeNewswire - February 15th, 2025
- Rosnilimab shows promise in rheumatoid arthritis trial - Investing.com - February 15th, 2025
- 5 foods that keep your joints strong and healthy - Mint - February 15th, 2025
- If You Have Arthritis, This New Makeup Brand Is for You - Money Talks News - February 15th, 2025
- Lower Your Risk Of Rheumatoid Arthritis With These 5 Basic Habits - mindbodygreen - February 15th, 2025
- 'I treat top athletes with arthritis - cupboard staple ingredients are quite effective for pain and swelling' - GB News - February 15th, 2025
- AnaptysBio Whipsaws On Promising Results In Rheumatoid Arthritis Treatment - Yahoo - February 15th, 2025
- Rheumatology enters the chat: research projects use AI and collaborative thinking to improve patient care - University of Alberta - February 15th, 2025
- In Patients with HS, a Closer Look at Stigmatization and Perceived Health Status - Medpage Today - February 15th, 2025
- Psoriatic Arthritis Treatment Market is Set To Fly High in Years to Come: AbbVie Inc., Amgen Inc., Johnson & - EIN News - February 15th, 2025
- Sandoz Rolls Out Rival Version Of AbbVie's Arthritis Drug Humira - BW Healthcare World - February 15th, 2025
- GSK To Bounce Regulatory Submissions For Experimental Arthritis Drug - BW Healthcare World - February 15th, 2025
- Living With Arthritis: Health Information Basics for You and Your ... - January 27th, 2025
- Rheumatoid Arthritis: Diagnosis, Treatment, and Steps to Take - January 27th, 2025
- Rheumatoid Arthritis | Health Topics | NIAMS - January 27th, 2025
- 6 Things to Know About Psoriatic Arthritis - Hartford HealthCare - January 27th, 2025
- MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway - Nature.com - January 27th, 2025
- Rheumatoid Arthritis Basics: Overview, Symptoms, and Causes - January 27th, 2025
- 8 Things You Should Do in Your 20s, 30s, and 40s to Prevent Joint Pain Later in Life - Self - January 27th, 2025
- 8 Natural Remedies to Relieve Join Pain and Improve Mobility - Health.com - January 27th, 2025
- East Texas vet tells what to watch for during cold weather in arthritic pets - KTRE - January 27th, 2025
- Research Shows a Link Between Inflammation in the Gut and Rheumatoid Arthritis - Health Central - January 27th, 2025
- Address to the Business Community Attend the Arthritis Foundation Event - TAPinto.net - January 27th, 2025
- The journey of 2-year-old with arthritis - PAHomePage.com - January 27th, 2025
- East Texas vet tells what to watch for during cold weather in arthritic pets - KLTV - January 27th, 2025
- Four tips for managing rheumatoid arthritis in the winter - Yahoo Lifestyle UK - January 27th, 2025
- Living with arthritis: Here's how diet, exercise, and daily habits can ease the pain - Moneycontrol - January 27th, 2025
- Sichuan wildlife park peddles tiger urine, claiming efficacy for rheumatoid arthritis, other conditions - Global Times - January 27th, 2025
- Non-surgical option to ease knee arthritis - The Week - January 27th, 2025
- Ease arthritis pain by adding 1 juice to your diet - Surrey Live - January 27th, 2025
- Four tips for managing rheumatoid arthritis in the winter - Yahoo News UK - January 27th, 2025
- Drinking one juice can ease arthritis pain, studies reveal - Daily Record - January 27th, 2025
- Annual Health Observances | NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) - October 6th, 2024
- Obesity dampens rheumatoid arthritis treatment effectiveness, satisfaction - Healio - October 6th, 2024
- Patient Perspectives: Finding Grace While Living With Rheumatoid Arthritis - Rheumatology Advisor - October 6th, 2024
- Rheumatoid arthritis tied to heavy economic and human burdens - Medical Xpress - October 6th, 2024
- Dual therapy can have synergistic effect in difficult-to-treat inflammatory diseases - Healio - October 6th, 2024
- Hand-Held Scanner Could Transform Cancer and Arthritis Diagnosis - Technology Networks - October 6th, 2024
- Medical imaging breakthrough could transform cancer and arthritis diagnosis - University College London - October 6th, 2024
- Citryll and leading rheumatology centres receive - GlobeNewswire - October 6th, 2024
- Its going to be ubiquitous: Weight loss drugs may aid rheumatic disease treatment - Healio - October 6th, 2024
- Comorbidities Associated With Psoriasis: 5 Things to Know - Medscape - October 6th, 2024
- Opinion: Let's treat arthritis with the seriousness it deserves - Vancouver Sun - October 6th, 2024
- New handheld scanner technology could transform cancer and arthritis diagnosis - The Engineer - October 6th, 2024
- Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology - Open Access Government - October 6th, 2024
- Handheld scanner could transform cancer and arthritis diagnosis study - The Independent - October 6th, 2024
- Ankylosing Spondylitis and Self-Care: 6 Science-Backed Tips - Everyday Health - October 6th, 2024
- From a Labrador with arthritis to a goldfishs lifespan your pet queries answered... - The Sun - October 6th, 2024
- 15 Home Essentials That Make Life Easier If You Have Arthritis - HuffPost - September 21st, 2024
- Gout, a painful form of arthritis, is on the rise. Avoiding red meat and alcohol can help. - Yahoo Life - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pain - MedicineNet - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - U.S. News & World Report - September 21st, 2024
- Arthritis can flare up in colder weather: Tips to easing the pan - Medical Xpress - September 21st, 2024
- See how Waymo is bringing Arthritis Foundation of Arizona families to the ballpark - ABC15 Arizona in Phoenix - September 21st, 2024
- Prevalence of Loneliness in Inflammatory Arthritis and its Association with Disease Activity - Physician's Weekly - September 21st, 2024
- Psoriatic Arthritis and Gluten: Whats the Link? - Health Central - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Southernminn.com - September 21st, 2024
- 6 Knee Injuries That Can Cause Arthritis - Health News Hub - September 21st, 2024
- The Best Rheumatoid Arthritis Self-Care Tips To Soothe Painful Joints and Improve Mobility - Yahoo Life - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - El Paso Inc. - September 21st, 2024
- Shifting kneecap in kids? Early ligament repair can prevent arthritis in young Age: Experts - The Times of India - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Shelbynews - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Citizentribune - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - News-Daily.com - September 21st, 2024
- Casavant: Access to virtual care at risk for millions of arthritis patients - Daily Independent - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Avery Journal Times - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - The Elkhart Truth - September 21st, 2024
- What To Eat (And Skip) on a Rheumatoid Arthritis Diet To Reduce Painful Inflammation - Woman's World - September 21st, 2024
- Tiny knee bone linked to arthritis may have helped humans walk upright, scientists suggest - Sky News - September 13th, 2024
- Medical Marijuana Helps People With Arthritis And Other Rheumatic Conditions Reduce Use Of Opioids And Other Medications, Study Shows - Marijuana... - September 13th, 2024
- My 'stomach bug' turned out to be an agonising pain condition that left me wheelchair bound within four years - Daily Mail - September 13th, 2024
- Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis - Nature.com - September 13th, 2024