New NIH studies seek adults and families affected by sickle cell disease/trait People with sickle cell disease (SCD) can experience excruciating pain, kidney problems, a higher risk of stroke and, in rare cases, chronic leg ulcers. Little is known about why the severity of these symptoms varies throughout a lifetime or why these symptoms differ from person to person. NHGRI researchers are seeking help from people affected by SCD to find the factors - environmental, social and genetic - that impact the severity of the symptoms. Read more Investigational Device Exemptions (IDE) and Genomics Workshop On Friday, June 10, 2016, the National Human Genome Research Institute (NHGRI) hosted the Investigational Device Exemptions (IDE) and Genomics Workshop. The workshop brought together perspectives from investigators, institutional review boards (IRB), the FDA and NHGRI on how to determine if a study requires an IDE, and how to fulfill IDE requirements if the FDA should require an IDE for research involving the use of genomic technologies, including next-generation sequencing (NGS). View agenda The Genomics Landscape Clinical Sequencing: Beyond Exploration The Genomics Landscape for June features exciting developments with NHGRI's Clinical Sequencing Exploratory Research Program. We also highlight the new director of the National Library of Medicine, recently funded studies on the ethical, legal and social implications of genomic information, the final seminar commemorating the 25th anniversary of the launch of the Human Genome Project and available online videos for genome analysis lectures. Read more Bacterial toxins make the body go boom By outward appearances, plants and animals don't seem to have much in common. When it comes to their immune systems, however, they might be more similar than their exteriors suggest. Researchers at the National Human Genome Research Institute have discovered an immune mechanism in humans, known as a "guard" mechanism, which was once thought to exist only in plants. They've published their results in the June 6 online journal Nature Immunology. Read more Perspective: Precision medicine may move us beyond the use of race in prescribing drugs Health care providers have long struggled with considering race when prescribing and dosing medications. In a May 26 New England Journal of Medicine perspective, Vence L. Bonham, J.D., an investigator with NHGRI's Social and Behavioral Research Branch, and his colleagues, are asking if the precision medicine approach will reduce or eliminate the role that race plays in prescribing drugs and in health care overall. Read more
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