StemCell Therapy

A new study has found elderly men with existing cardiometabolic disease with a version of a gene associated with longevity and aging in humans appeared to have a reduced risk of death.

The gene in question, Forkhead Box O3 (FOXO3) has long been highlighted in the past as being important in the aging process.

Chronic cardiometabolic diseases of aging such as diabetes, heart disease, and high blood pressure increases the risk of death and a shorter lifespan.

The study followed 3,584 men from the Kuakini Honolulu Heart Program in Honolulu, Hawaii, to examine the effects of the longevity version (alleles) of the FOXO3 gene in men with cardiometabolic diseases and found they lived just as long as men who did not have the disease.

The findings were presented in a paper published in Aging

The work was conducted by an international team, including researchers at the University of Sydney and the University of Hawaii.

Emeritus Professor Brian Morris from the Faculty of Medicine and Health, University of Sydney was corresponding author on the paper.

We have found for the first time that the remaining lifespan of elderly men with longevity associated alleles (versions) of FOXO3 who have one of more chronic conditions of ageing, such as diabetes and hypertension live as long as elderly men who lack any of these lifethreatening conditions, says Emeritus Professor Morris.

This suggests that expression of this particular version of FOXO3 in humans appears to impact what would otherwise be an increased risk for mortality in men with prevalent cardiometabolic conditions.

More:
Longevity gene could be key in reducing risk of death for men with chronic disease - News - The University of Sydney

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