StemCell Therapy

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These two authors contributed equally to this work

Using a histone FRAP method, this study identifies Gadd45a as a chromatin relaxer and somatic cell reprogramming enhancer. Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

Using a histone FRAP method, this study identifies Gadd45a as a chromatin relaxer and somatic cell reprogramming enhancer. Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

FRAP is used to assess heterochromatin/euchromatin dynamics in somatic cell reprogramming.

Gadd45a is a chromatin relaxer and improves somatic cell reprogramming.

Gadd45a destabilizes histoneDNA interactions and facilitates the binding of Yamanaka factors to their targets.

Keshi Chen, Qi Long, Tao Wang, Danyun Zhao, Yanshuang Zhou, Juntao Qi, Yi Wu, Shengbiao Li, Chunlan Chen, Xiaoming Zeng, Jianguo Yang, Zisong Zhou, Weiwen Qin, Xiyin Liu, Yuxing Li, Yingying Li, Xiaofen Huang, Dajiang Qin, Jiekai Chen, Guangjin Pan, Hans R Schler, Guoliang Xu, Xingguo Liu, Duanqing Pei

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