References
Abdelmohsen K, Panda A, Kang MJ et al. (2013) Senescenceassociated lncRNAs: senescenceassociated long noncoding RNAs. Aging Cell 12: 890900.
Anselmi CV, Malovini A, Roncarati R et al. (2009) Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Research 12: 95104.
Atzmon G, Cho M, Cawthon RM et al. (2010) Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the USA 107 (Suppl 1): 17101717.
Barzilai N, Atzmon G, Schechter C et al. (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA: The Journal of the American Medical Association 290: 20302040.
Beekman M, Blanche H, Perola M et al. (2013) Genomewide linkage analysis for human longevity: genetics of Healthy Aging Study. Aging Cell 12: 184193.
Beekman M, Nederstigt C, Suchiman HE et al. (2010) Genomewide association study (GWAS)identified disease risk alleles do not compromise human longevity. Proceedings of the National Academy of Sciences of the USA 107: 1804618049.
Bell JT, Tsai PC, Yang TP et al. (2012) Epigenomewide scans identify differentially methylated regions for age and agerelated phenotypes in a healthy ageing population. PLoS Genetics 8: e1002629.
Bonafe M, Barbieri M, Marchegiani F et al. (2003) Polymorphic variants of insulinlike growth factor I (IGFI) receptor and phosphoinositide 3kinase genes affect IGFI plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. Journal of Clinical Endocrinology and Metabolism 88: 32993304.
Bonafe M, Marchegiani F, Cardelli M et al. (2002) Genetic analysis of Paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians. European Journal of Human Genetics: EJHG 10: 292296.
Boyden SE and Kunkel LM (2010) Highdensity genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS One 5: e12432.
Campo S, Sardo MA, Trimarchi G et al. (2004) Association between serum paraoxonase (PON1) gene promoter T(107)C polymorphism, PON1 activity and HDL levels in healthy Sicilian octogenarians. Experimental Gerontology 39: 10891094.
Carrieri G, Marzi E, Olivieri F et al. (2004) The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians. Aging Cell 3: 443448.
Deelen J, Beekman M, Uh HW et al. (2011) Genomewide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 10: 686698.
Deelen J, Beekman M, Uh HW et al. (2014) Genomewide association metaanalysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics 23: 44204432.
Deelen J, Uh HW, Monajemi R et al. (2013) Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF1 signaling and telomere maintenance pathways. Age 35: 235249.
Eggertsen G, Tegelman R, Ericsson S, Angelin B and Berglund L (1993) Apolipoprotein E polymorphism in a healthy Swedish population: variation of allele frequency with age and relation to serum lipid concentrations. Clinical Chemistry 39: 21252129.
Flachsbart F, Caliebe A, Kleindorp R et al. (2009) Association of FOXO3A variation with human longevity confirmed in German centenarians. Proceedings of the National Academy of Sciences of the USA 106: 27002705.
Garatachea N, Emanuele E, Calero M et al. (2014) ApoE gene and exceptional longevity: insights from three independent cohorts. Experimental Gerontology 53: 1623.
Gaspari L, Pedotti P, Bonafe M et al. (2003) Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 8: 522528.
Gombar S, Jung HJ, Dong F et al. (2012) Comprehensive microRNA profiling in Bcells of human centenarians by massively parallel sequencing. BMC Genomics 13: 353364.
Gro S, UtaDorothee I, Klintschar M and Bartel F (2014) Germline genetics of the p53 pathway affect longevity in a gender specific manner. Current Aging Science. doi:10.2174/1874609807666140321150751 (Epub ahead of print).
HalaschekWiener J, Vulto I, Fornika D et al. (2008) Reduced telomere length variation in healthy oldest old. Mechanisms of Ageing and Development 129: 638641.
Hannum G, Guinney J, Zhao L et al. (2013) Genomewide methylation profiles reveal quantitative views of human aging rates. Molecular Cell 49: 359367.
van Heemst D, Beekman M, Mooijaart SP et al. (2005a) Reduced insulin/IGF1 signalling and human longevity. Aging Cell 4: 7985.
van Heemst D, Mooijaart SP, Beekman M et al. and Long Life study g (2005b) Variation in the human TP53 gene affects old age survival and cancer mortality. Experimental Gerontology 40: 1115.
vB Hjelmborg J, Iachine I, Skytthe A et al. (2006) Genetic influence on human lifespan and longevity. Human Genetics 119: 312321.
Hurme M, Lehtimaki T, Jylha M, Karhunen PJ and Hervonen A (2005) Interleukin6 174G/C polymorphism and longevity: a followup study. Mechanisms of Ageing and Development 126: 417418.
Kerber RA, O'Brien E, Boucher KM, Smith KR and Cawthon RM (2012) A genomewide study replicates linkage of 3p2224 to extreme longevity in humans and identifies possible additional loci. PLoS One 7: e34746.
Kojima T, Kamei H, Aizu T et al. (2004) Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulinlike growth factor 1 signaling pathways. Experimental Gerontology 39: 15951598.
Lee JH, Cheng R, Honig LS et al. (2014) Genome wide association and linkage analyses identified three loci4q25, 17q23.2, and 10q11.21associated with variation in leukocyte telomere length: the Long Life Family Study. Frontiers in Genetics 4: 310.
Li Y, Wang WJ, Cao H et al. (2009) Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Human Molecular Genetics 18: 48974904.
Lio D, Scola L, Crivello A et al. (2002) Genderspecific association between 1082 IL10 promoter polymorphism and longevity. Genes and Immunity 3: 3033.
Lunetta KL, D'Agostino RB Sr., Karasik D et al. (2007) Genetic correlates of longevity and selected agerelated phenotypes: a genomewide association study in the Framingham Study. BMC Medical Genetics 8 (Suppl 1): S13.
Moskalev AA, Aliper AM, SmitMcBride Z, Buzdin A and Zhavoronkov A (2014) Genetics and epigenetics of aging and longevity. Cell Cycle 13: 10631077.
Murabito JM, Yuan R and Lunetta KL (2012) The search for longevity and healthy aging genes: insights from epidemiological studies and samples of longlived individuals. Journals of Gerontology Series A, Biological Sciences and Medical Sciences 67: 470479.
Nebel A, Kleindorp R, Caliebe A et al. (2011) A genomewide association study confirms APOE as the major gene influencing survival in longlived individuals. Mechanisms of Ageing and Development 132: 324330.
Newman AB, Glynn NW, Taylor CA et al. (2011) Health and function of participants in the Long Life Family Study: a comparison with other cohorts. Aging 3: 6376.
Noren Hooten N, Fitzpatrick M, Wood WH III et al. (2013) Agerelated changes in microRNA levels in serum. Aging 5: 725740.
Pawlikowska L, Hu D, Huntsman S et al. (2009) Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8: 460472.
Schachter F, FaureDelanef L, Guenot F et al. (1994) Genetic associations with human longevity at the APOE and ACE loci. Nature Genetics 6: 2932.
Sebastiani P, Bae H, Sun FX et al. (2013) Metaanalysis of genetic variants associated with human exceptional longevity. Aging 5: 653661.
Sebastiani P, Riva A, Montano M et al. (2011) Whole genome sequences of a male and female supercentenarian, ages greater than 114 years. Frontiers in Genetics 2: 90.
Sebastiani P, Solovieff N, Dewan AT et al. (2012) Genetic signatures of exceptional longevity in humans. PLoS One 7: e29848.
Soerensen M, Dato S, Tan Q et al. (2012a) Human longevity and variation in GH/IGF1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Experimental Gerontology 47: 379387.
Soerensen M, Dato S, Tan Q et al. (2013) Evidence from casecontrol and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. Age 35: 487500.
Soerensen M, Thinggaard M, Nygaard M et al. (2012b) Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a crosssectional and longitudinal analysis. Aging Cell 11: 223227.
Stessman J, Maaravi Y, HammermanRozenberg R et al. (2005) Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. Mechanisms of Ageing and Development 126: 333339.
Willcox BJ, Donlon TA, He Q et al. (2008) FOXO3A genotype is strongly associated with human longevity. Proceedings of the National Academy of Sciences of the USA 105: 1398713992.
Willcox BJ, He Q, Chen R et al. (2006) Midlife risk factors and healthy survival in men. JAMA: the Journal of the American Medical Association 296: 23432350.
Xia Y, Gueguen R, VincentViry M, Siest G and Visvikis S (2003) Effect of six candidate genes on early aging in a French population. Aging Clinical and Experimental Research 15: 111116.
Further Reading
Andersen SL, Sebastiani P, Dworkis DA, Feldman L and Perls TT (2012) Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span. Journals of Gerontology Series A, Biological Sciences and Medical Sciences 67: 395405.
Chang AL, Bitter PH Jr., Qu K et al. (2013) Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. Journal of Investigative Dermatology 133: 394402.
Chung WH, Dao RL, Chen LK and Hung SI (2010) The role of genetic variants in human longevity. Ageing Research Reviews 9 (Suppl 1): S67S78.
Kahn AJ (2014) FOXO3 and related transcription factors in development, aging, and exceptional longevity. Journals of Gerontology Series A, Biological Sciences and Medical Sciences. doi: 10.1093/gerona/glu044 (Epub ahead of print).
LabatRobert J and Robert L (2014) Longevity and aging. Role of free radicals and xanthine oxidase. A review. PathologieBiologie 62: 6166.
Raichlen DA and Alexander GE (2014) Exercise, APOE genotype, and the evolution of the human lifespan. Trends in Neurosciences 37: 247255.
Rajpathak SN, Liu Y, BenDavid O et al. (2011) Lifestyle factors of people with exceptional longevity. Journal of the American Geriatrics Society 59: 15091512.
Seripa D, D'Onofrio G, Panza F et al. (2011) The genetics of the human APOE polymorphism. Rejuvenation Research 14: 491500.
Sevini F, Giuliani C, Vianello D et al. (2014) mtDNA mutations in human aging and longevity: controversies and new perspectives opened by highthroughput technologies. Experimental Gerontology 56: 234244.
Zhu H, Belcher M and van der Harst P (2011) Healthy aging and disease: role for telomere biology? Clinical Science 120: 427440.
Read this article:
Genetics and Genomics of Human Longevity
- Diet or genetics: Which has a greater impact on lifespan? - India Today - October 22nd, 2024
- Dietary restriction or good genes: new study tries to unpick which has a greater impact on lifespan - The Conversation - October 22nd, 2024
- Comparison of blood parameters in two genetically different groups of horses for functional longevity in show jumping - Frontiers - October 22nd, 2024
- Dietary restriction impacts health and lifespan of genetically diverse mice - Nature.com - October 14th, 2024
- Study: Eating Less Could Significantly Improve LifespanIf You Have Good Genes - NTD - October 14th, 2024
- New Research Reveals Genetic Tweaks to Boost Oat Nutrition and Longevity - India Education Diary - October 14th, 2024
- imaware acquires binx health’s consumer testing business, becoming a leader in STI health screening - December 5th, 2023
- Catalyst Pharmaceuticals Announces Appointment of Michael W. Kalb as Chief Financial Officer and Other Executive Promotions - December 5th, 2023
- CorMedix Inc. Announces Partnership With The Leapfrog Group - December 5th, 2023
- Sunshine Biopharma Moves Principal Office to New York City - December 5th, 2023
- Viracta Therapeutics Announces Interim Data from Phase 1b/2 Clinical Trial of Nana-val in Patients with Epstein-Barr Virus-Positive Solid Tumors that... - December 5th, 2023
- SELLAS Life Sciences Announces Positive Recommendation from REGAL Independent Data Monitoring Committee of Galinpepimut-S in Acute Myeloid Leukemia - December 5th, 2023
- Inhibikase Therapeutics Granted Pre-NDA Meeting with the FDA for IkT-001Pro - December 5th, 2023
- NeuroStar TMS Receives Expanded Regulatory Approval in Japan - December 5th, 2023
- Harvard Apparatus Regenerative Technology and Renowned Professor/Physician Establish a Collaboration to Repair and Regenerate the Uterus - December 5th, 2023
- Scilex Holding Company announces the addition of ZTlido® (lidocaine topical system) as a preferred agent to the Medicaid Preferred Drug List (PDL) of... - December 5th, 2023
- GT Biopharma Announces IND Submission for GTB-3650 for Treatment of CD33+ Leukemia - December 5th, 2023
- Taking years off your age? This Israeli expert says its all up to you - Haaretz - November 7th, 2022
- Joris Deelen to present at the 9th Aging Research & Drug Discovery Meeting 2022 - EurekAlert - April 2nd, 2022
- LeBron James Can Become The GOAT: He Surpassed Michael Jordan In Almost Every Category Except Championships, MVP Awards And Finals MVPs - Fadeaway... - April 2nd, 2022
- Herd genetics begins with the bull | Agriculture | victoriaadvocate.com - Victoria Advocate - April 2nd, 2022
- InsideTracker x Apple Watch, Better Paired Together to Deliver Personalized Health Insights, Science-Backed Guidance for Human Optimization - PR... - April 2nd, 2022
- 10 Foods That Are Awesome When It Comes To Breast Health - The List - April 2nd, 2022
- The secret to making your brain work better - Financial Times - April 2nd, 2022
- Irish study finds eight novel ways to live longer (it's not all diet and genes) - The Irish Times - January 17th, 2022
- Independent Seed Companies Aspire for Longevity and Differentiation - Seed World - January 17th, 2022
- The benefits of intermittent fasting the right way - BBC News - January 17th, 2022
- Lifeist Subsidiary Mikra Cellular Sciences to Launch First Product CELLF to Combat Brain Fog and Unlock Healthy Aging, Announces U.S. Patent... - December 8th, 2021
- Longevity and anti-aging research: Prime time for an ... - November 21st, 2021
- North American South Devon Association - November 21st, 2021
- Can drinking red wine ever be good for us? - BBC Future - November 21st, 2021
- Gero scientists found a way to break the limi | EurekAlert! - November 21st, 2021
- Embark sponsors The National Dog Show, in commitment to improving life and longevity of all dogs - PRNewswire - November 21st, 2021
- In most ways, women age better than men and live longer. Scientists are trying to figure out why. - The Philadelphia Inquirer - November 21st, 2021
- Inherited Metabolic Disorders Market Study | Know the prominent factors that will help in reshaping the market growth - BioSpace - November 21st, 2021
- Why Hangovers Get Worse as You Age, and What to Do About It - Livestrong - November 21st, 2021
- Addicted to coffee? Heres how it can be harmful to your health - Khaleej Times - November 21st, 2021
- Animal Expert Shares 5 Things That Will Help Your Dog Live a Longer, Healthier Life - ScienceAlert - August 30th, 2021
- The Bat Elixir: Geneticists Suspect that the Flying Mammal Holds the Key to Extended Healthy Life | The Weather Channel - Articles from The Weather... - August 30th, 2021
- Greenland Sharks Live Hundreds of Years; Can These Sharks Teach Humans How to Live Long? - Science Times - August 30th, 2021
- 9 Healthy Eating Habits to Live Over A Century, Say Dietitians | Eat This Not That - Eat This, Not That - August 30th, 2021
- 95 and Counting - Arlington Connection - June 24th, 2021
- What Lifestyle Decisions Will Help You Become a "Cognitive Super-Ager"? - InsideHook - June 24th, 2021
- Wentworth weight gains steal the Wagyu show - Queensland Country Life - June 24th, 2021
- People on the Move: Appointments, retirements, achievements - Beef Central - June 24th, 2021
- Pandemic Lessons in Improving the Medical System - The New York Times - February 14th, 2021
- The Role of Hormones in Immunocompetence - Anti Aging News - February 14th, 2021
- Do Short People Live Longer? What We Know - Healthline - February 1st, 2021
- Hereford Thrives In Uncertain Year - Drovers Magazine - February 1st, 2021
- Women's Menstrual Cycles Tied to Moon's Phases - HealthDay News - February 1st, 2021
- Is The Full Moon Affecting Your Sleep and Flow? - Longevity LIVE - Longevity LIVE - February 1st, 2021
- Calico Purring Right Along With Life Extension Research - Nanalyze - February 1st, 2021
- Dr. William Kelley inducted into IAOTPs Hall of Fame - PRUnderground - February 1st, 2021
- Baptist Health of Northeast Florida Joins Forces with Blue Zones to Begin Building a Plan for Well-Being Transformation in Jacksonville - PR Web - February 1st, 2021
- Is longevity determined by genetics?: MedlinePlus Genetics - January 25th, 2021
- Optogenetics Shows How the Microbiome Affects Longevity - January 25th, 2021
- 9 Factors That Affect Longevity | ThinkAdvisor - January 25th, 2021
- Hereford thrives in an uncertain year | Farm Forum | aberdeennews.com - AberdeenNews.com - January 25th, 2021
- Njonjo, Moody Awori: Why these wazee are still up and running - The Standard - January 25th, 2021
- Son reported father to FBI weeks before he reportedly stormed the Capitol - Yahoo News - January 25th, 2021
- Study of More Than 1 Million People Finds Intriguing Link Between Iron Levels And Lifespan - ScienceAlert - January 5th, 2021
- Hereford Thrives in an Uncertain Year - AG INFORMATION NETWORK OF THE WEST - AGInfo Ag Information Network Of The West - January 5th, 2021
- Covid-19 Update Precision Medicine Software market: Poised to Garner Maximum Revenues by 2027 with major key players in the market Syapse, Allscripts,... - January 5th, 2021
- The New Anti-Ageing: How the pandemic unlocked new ways to lower your biological age - Telegraph.co.uk - January 5th, 2021
- A Good Age: Auld lang syne to the eldest who inspired and entertained us - The Patriot Ledger - January 5th, 2021
- Survival Of The Kindest: A New Mantra To Rebuild The Global Economy - Forbes - January 5th, 2021
- The Nashville bombing suspect sent packages to people across the country containing typed conspiracy theories about September 11 and lizard people,... - January 5th, 2021
- How does the human body react to being in space? - Sciworthy - December 24th, 2020
- A century and counting: Ardmore woman turned 100 on Friday - Daily Ardmoreite - December 24th, 2020
- The Adrenomyeloneuropathy Treatment Market to grow on an emphatic note from 2019 to 2029 - PharmiWeb.com - December 24th, 2020
- Getting to the root of why hair goes gray - messenger-inquirer - December 24th, 2020
- Which countries have the highest life expectancy in Europe? - World Economic Forum - December 17th, 2020
- New Research Aims To Increase Longevity Of Bumblebee Hives For NZ Growers - Scoop.co.nz - December 17th, 2020
- The 'Wondrous Map': Charting of the Human Genome, 20 Years Later - Medscape - December 17th, 2020
- Size Matters, And Other Lessons From Medical Genetics - Genomes Unzipped - December 17th, 2020
- Intermittent Fasting Not Working? Here's What Could Be Going Wrong, By an RD - The Beet - December 17th, 2020
- Hair loss treatment: Sandalwood and sandalore are both effective in increasing hair growth - Express - December 17th, 2020
- These are the signs and symptoms of dementia - and the stages explained - Yorkshire Post - December 17th, 2020
- Manahawkin Woman 'Scales' 100 Years With Service, Strength and Determination - The SandPaper - December 17th, 2020
- 15 Things To Stop Doing If You Want To Live To 100 - Longevity LIVE - Longevity LIVE - December 4th, 2020