StemCell Therapy

ABC Health

Updated:10/07/202017:28h

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Spanish researchers have seen that a fat stem cell therapy improves the prognosis in patients with Covid-19. The research, which has just been published in ClinicalMedicine, magazine that belongs to the group The Lancet, shows that a cell therapy with stem cells from adipose tissue for the treatment of critically ill patients covid-19, which has been applied through a compassionate use program, reduces 75% of treated patients inflammation and increases the activity of your immune system.

The patients included in this study have been treated in four Spanish centers: Fundacin Jimnez Daz, the Clnica Universidad de Navarra, the Hospital Universitario de Salamanca and the Hospital General Universitario Gregorio Maran.

Research has evaluated the tolerability and safety of administration to patients of adipose tissue-derived mesenchymal stem cells. Mesenchymal stem cells, known as multipotent cells, can differentiate into various cell types while maintaining a high capacity for renewal.

Those coming from adipose tissue cells (adipocytes) They have anti-inflammatory and immunomodulatory effects, are easily accessible and have a great capacity to expand also in the laboratory over long periods of time without losing their characteristics.

Advanced mesenchymal stem cell therapy is already approved for some inflammatory diseases. In turn, there is preclinical evidence that intravenous administration of this cell therapy in models of respiratory infection caused by viruses reduces lung damage. For this reason, together with the fact of the role of inflammation in the pathogenesis of lung damage associated with SARS-CoV-2, we think that this therapy could be a beneficial alternative for severe covid-19 patients , points out the Felipe Prosper, senior researcher at Up.

The research presents the results of a study in which cells have been treated for the first time mother mesenquimales Covid-19 patients undergoing mechanical ventilation. In our Cell Production units we have been able to store these stem cells and have them available to administer to the 13 patients participating in the study.

They were all in critical condition and they had previously received treatment with antivirals and anti-inflammatories, a therapeutic protocol that is currently being used to combat the disease, he explains. Francisco Fernndez-Avils, of the Gregorio Maran General University Hospital.

Patients received between one and three doses of these cells from healthy donors. Two weeks after the first dose, nine patients improved their clinical condition and seven were already extubated and out of the ICU. In no case did we observe any adverse effects related to treatment , confirms Fermn Snchez-Guijo, of the University Hospital of Salamanca and of Institute of Biomedical Research of Salamanca (IBSAL), and first signatory of the published work.

In this preliminary series of cases, the researchers observed a general improvement of ventilation, radiological and biological parameters of patients associated with this cell therapy. According to the experts, the results obtained in this study represent the basis for further progress in order to demonstrate whether this treatment is really effective in patients with covid-19 pneumonia.

The therapy already has the approval of the Spanish Agency for Medicines and Health Products (AEMPS) to carry out the phase 2 clinical trial whose objective will be to demonstrate the efficacy of the treatment against standard therapy.

This work is the first published study that includes a series of patients with severe Covid-19 pneumonia treated with this cell therapy. Currently, multiple studies have been started with stem cells in patients with covid-19 pneumonia, both in Spain and in other countries of the world, in which the use of various sources of stem cells such as bone marrow, fat, or placenta .

We are convinced that our results are particularly relevant as they support the performance of these studies, says the doctor. Damin Garca Olmo, from Jimnez Daz Foundation.

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Fat stem cells improve prognosis in patients with Covid-19 ...

This entry was posted on July 11, 2020 at 1:45 pm and is filed under Fat Stem Cells. You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed. |