StemCell Therapy

Motoo Kobayashi,1,2,* Yuki Okada,1,2,* Hiromichi Ueno,1 Takayuki Mizorogi,1 Kenji Ohara,1 Koh Kawasumi,1 Kohei Suruga,3 Kazunari Kadokura,3 Yasuyuki Ohnishi,2 Toshiro Arai1,2

1Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8601, Japan; 2One Health Co. Ltd, Tokyo 157-0066, Japan; 3Food Function R&D Division, International Operation Department, Kibun Foods Inc., Tokyo 206-0812, Japan

*These authors contributed equally to this work

Correspondence: Toshiro AraiLaboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo 180-8601, JapanTel +81 422 31 4151Fax +81 422 31 7841Email tarai@nvlu.ac.jp

Background: Obesity has become a serious public health problem all over the world, and prevalence of obesity has increased in cats. Obesity is characterized by continuous low-grade inflammation based on oxidative stress by excessively produced reactive oxygen species (ROS). Supplementation with anti-oxidant and anti-inflammatory compounds is very effective to relieve the obesity condition. A plant extract mixture containing Rhus verniciflua and some other herbs, Rv-PEM01-99, shows anti-oxidant and anti-inflammatory effects in animals. The aim of this study was to evaluate the effects of supplementation with Rv-PEM01-99 as an anti-inflammatory compound in healthy and obese cats.Materials and Methods: Ten healthy mix breed cats and four obesity disease cats were used. The healthy cats were randomly divided into control and test groups. Anti-inflammatory compound, Rv-PEM01-99, in which quercetin derivative is the main component, was supplemented to the healthy test group and the obesity disease cats at the dose of 100 120 mg/kg/day (2.5 3.0 mg/kg/day as quercetin) for 4 weeks. Metabolites, hormones and enzymes were measured before and after the compound supplementation.Results: The anti-inflammatory compound supplementation decreased serum amyloid A (SAA) concentrations as inflammatory markers in both healthy and obesity disease cats. In obesity disease cats, plasma total cholesterol concentrations and AST and ALT activities decreased significantly after the compound supplementation.Conclusion: Quercetin derivative seems to have strong anti-inflammatory activities. In the healthy cats, anti-inflammatory compound supplementation decreased plasma NEFA and SAA concentrations. In the obesity disease cats, the compound supplementation may have alleviated obesity disease by relieving inflammation and improvement of lipid metabolism in livers.

Keywords: anti-inflammatory compound, cat, obesity, quercetin, SAA

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