StemCell Therapy

PURPOSE:

We investigated whether the relationship between diabetes and all-cause and CVD-related mortality differed between women with and withoutbreast canceramong a cohort drawn from the same source population.

We interviewed 1,363 women newly diagnosed withbreast cancerin 1996-1997, and 1,358 age-matched women withoutbreast cancer, to assess history of physician-diagnosed diabetes. All-cause (n=631) and CVD-specific mortality (n=234) was determined by the National Death Index through 2009. We estimated multivariable-adjusted hazard ratios (HRs) for the rates of all-cause and CVD-specific mortality and, to account for competing causes of death, and subdistribution HRs (sHRs) for risk of CVD-related death.

Among women with and withoutbreast cancer, respectively, diabetes was associated with: all-cause mortality [HR (95% CI) 1.52 (1.13, 2.05) and 2.17 (1.46, 3.22)]; CVD-specific deaths [1.74 (1.06, 2.84) and 2.06 (1.11, 3.84)]; and risk of CVD-related death [sHR 1.36 (0.81, 2.27) and 1.79 (0.94, 3.40)]. Differences in effect estimates between women with and withoutbreast cancerdid not reach statistical significance (p-interaction>0.10).

We found that the positive association between a history of physician-diagnosed diabetes and risk of all-cause and CVD-related mortality is of similar magnitude among a population-based cohort of women with or withoutbreast cancer.

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Diabetes and Cardiovascular Disease Mortality Among A Population-Based Cohort of Women with and Without Breast Cancer - DocWire News

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