StemCell Therapy

History of the Department

On the following page is a brief history of the department, along with a video entitled The First 48 Years of the Department of Genetics at the University of Pennsylvania. On the subsequent page there are four additional videos: The Billingham Chairmanship and Transplantation Immunology (Clyde Barker and David Gasser), The Mellman Chairmanship and Cytogenetics (Beverly Emanuel and David Gasser), The Mellman Chairmanship and Maternal/Fetal Medicine (Michael Mennuti and David Gasser), and The Kazazian Chairmanship (Haig Kazazian and David Gasser). Read and view more about the department...

The Department of Genetics hosts a different speaker every Monday of the academic year, with invitees ranging from postdoctoral researchers to prominent scientists presenting a broad array of current, genetics-related research. Our series is cosponsored with the Department of Cell and Developmental Biology, the Epigenetics Program, and the Institute for Regenerative Medicine. Click here to view the schedule.

We are pleased to announce that this year's Tom Kadesch Prize in Genetic Research has been awarded to Derek Oldridge.

Dan Rader, Rebecca Mueller, Derek Oldridge, Abby Huntington, Hannah Kadesch, John Maris

We are pleased to announce the recruitment of Golnaz Vahedi, Ph.D.Golnaz received her Ph.D. in Computational Biology from Texas A&M in 2009, where she studied gene regulatory networks applying Boolean probabilistic modeling and other methods. After developing her interest in regulatory networks controlling gene expression, Golnaz joined Dr. John OSheas laboratory at the National Institutes of Health in 2009. During her postdoctoral training Dr. Vahedi made seminal findings in the area of epigenetic and transcription factor control of cell fate in the immune system. Golnaz will join the Department as a tenure track Assistant Professor on May 1, 2015. Her arrival is expected to further strengthen and expand the Department's capacities in the computational and bioinformatics aspects of immunogenetics.

Yoseph Barash In silico to in vivo splicing analysis using splicing code models. Gazzara MR, Vaquero-Garcia J, Lynch KW, Barash Y. Methods. S1046-2023(13)00444-1, 2013.

AVISPA: a web tool for the prediction and analysis of alternative splicing. Barash Y, Vaquero-Garcia J, Gonzlez-Vallinas J, Xiong HY, Gao W, Lee LJ, Frey BJ. Genome Biol. 14(10):R114, 2013.

Maja Bucan From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes. Georgi B, Voight BF, Bucan M PLoS Genet. 2013. 9(5): e1003484.

Genomic View of Bipolar Disorder Revealed by Whole Genome Sequencing in a Genetic Isolate Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bucan M PLoS Genet 10(3): e1004229. doi:10.1371/journal.pgen.1004229, 2014.

Doug Epstein Divergent roles for Wnt/-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation. Rakowiecki S,Epstein DJ. Development 140(8):1730-9, 2013.

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Trowe MO, Zhao L, Weiss AC, Christoffels V,Epstein DJ, Kispert A. Development 140(11):2299-309, 2013.

Arupa Ganguly Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation. Bunin GR, Li Y, Ganguly A, Meadows AT, Tseng M. Cancer Causes Control. 2013 Feb;24(2):343-55. doi: 10.1007/s10552-012-0120-x. Epub 2012 Dec 8.

A case-control study of paternal occupational exposures and the risk of childhood sporadic bilateral retinoblastoma. Abdolahi A, van Wijngaarden E, McClean MD, Herrick RF, Allen JG, Ganguly A, Bunin GR. Occup Environ Med. 2013 Jun;70(6):372-9. doi: 10.1136/oemed-2012-101062. Epub 2013 Mar 16.

Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome. Ewens KG, Kanetsky PA, Richards-Yutz J, Al-Dahmash S, De Luca MC, Bianciotto CG, Shields CL, Ganguly A. Invest Ophthalmol Vis Sci. 2013 Aug 23;54(8):5721-9. doi: 10.1167/iovs.13-12195.

Dominant form of congenital hyperinsulinism maps to HK1 region on 10q. Pinney SE, Ganapathy K, Bradfield J, Stokes D, Sasson A, Mackiewicz K, Boodhansingh K, Hughes N, Becker S, Givler S, Macmullen C, Monos D, Ganguly A, Hakonarson H, Stanley CA. Horm Res Paediatr. 2013;80(1):18-27. doi: 10.1159/000351943. Epub 2013 Jul 13.

Enhanced Sensitivity for Detection of Low-Level Germline Mosaic RB1 Mutations in Sporadic Retinoblastoma Cases Using Deep Semiconductor Sequencing. Chen Z, Moran K, Richards-Yutz J, Toorens E, Gerhart D, Ganguly T, Shields CL, Ganguly A. Hum Mutat. 2013 Nov 26. doi: 10.1002/humu.22488. [Epub ahead of print]

David Gasser Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10. Gasser DL, Winkler CA, Peng M, An P, McKenzie LM, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF and Kopp JB. Am J Physiol Renal Physiol 305(8): F1228-F1238, 2013.

Yugong Ho An -regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus Ho Y, Cooke NE, Liebhaber SA. Mol Cell Biol. In Press.

Stephen Liebhaber An -regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus Ho Y, Cooke NE, Liebhaber SA. Mol Cell Biol. In Press.

TissueSpecific CTCF Occupancy andBoundary Function at the Human Growth HormoneLocus Tsai, Y-C, Cooke, NE, and Liebhaber, SA Nucleic Acids Research. 42: 4906-21., 2014.

Specific enrichment of the RNA-bindingproteins PCBP1 and PCBP2 in chief cells of the murinegastric mucosa Ghanem,LR, Chatterji, P, and Liebhaber, SA Gene Expression Patterns. 14:78-87, 2014. Autonomous Actions of theHumanGrowth Hormone Long-Range Enhancer Yoo, EJ, Brown, CD., Tsai, Y-C, Cooke, NE, and Liebhaber, SA Nucleic Acids Research. 2015.

Julia I-Ju Leu Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. Leu JI, Zhang P, Murphy ME, Marmorstein R, George DL ACS Chem Biol. 9(11): 2508-16, 2014.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R PLoS One. 9(7): e103518, 2014.

Meera Sundaram A cell non-autonomous role for Ras signaling in C. elegans neuroblast delamination Parry, J. M. and Sundaram, M. V. Development 141: 4279-4284, 2014.

Sarah Tishkoff Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent. Aminkeng F, Ross CJ, Rassekh SR, Brunham LR, Sistonen J, Dube MP, Ibrahim M, Nyambo TB, Omar SA, Froment A, Bodo JM, Tishkoff S, Carleton BC, Hayden MR. The Pharmacogenomics Journal J. doi: 10.1038/tpj. 2013.

Comparison Between Southern Blots and qPCR Analysis of Leukocyte Telomere Length in the Health ABC Study. Elbers CC, Garcia ME, Kimura M, Cummings SR, Nalls MA, Newman AB, Park V, Sanders JL, Tranah GJ, Tishkoff SA, Harris TB, Aviv A. The journals of gerontology. Series A, Biological sciences and medical sciences, published online ahead of print, 2013.

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure. Gomez F, Tomas G, Ko WY, Ranciaro A, Froment A,Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Hirbo JB, Rocha J, Tishkoff SA. Human Genetics 132(9): 987-99, 2013.

Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Ko WY, Rajan P, Gomez F,Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. American Journal of Human Genetics 93(1): 54-66, 2013.

Great ape genetic diversity and population history. Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprub C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrs AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T. Nature. 499(7459):471-5. 2013. Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa. Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo JB, Thompson SI, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo J-M, Nyambo T, Belay G, Drayna D, Breslin PAS, Tishkoff SA. Molecular Biology and Evolution, Advanced online publication. 2013.

Zhaolan (Joe) Zhou Cellular origins of auditory event-related potential deficits in Rett syndrome Goffin D, Brodkin ES, Blendy JA, Siegel SJ and Zhou Z Nature Neuroscience. 17(6): 804-806, 2014.

Yoseph Barash has been awarded an R01 from the National Institute on Aging. Title: Modeling Splicing in normal tissues and neurodegenerative disease R01 AG046544-01A1

Joe Zhou has been awarded an R01 from the NINDS. Title: Understanding the Pathogenic Mechanisms of Rett Syndrome R01-NS081054

Donna George has been awarded a P01 from the NCI. Title: Targeted Therapies in Melanoma 2P01 CA114046-06

John Murray has been awarded an R01 from the NIH. Title: Mechanisms integrating lineage history with fate specification in C. elegans 1R01GM105676-01A1

Casey Brown has been awarded an R01 from the NIMH. Title: Identification and validation of cell specific eQTLs by Bayesian modeling 1-R01-MH101822-01

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Department of Genetics || University of Pennsylvania

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