StemCell Therapy

TORONTO, Aug. 22, 2024 (GLOBE NEWSWIRE) -- Firefly Neuroscience, Inc. (“Firefly,” “we,” or the “Company”) (NASDAQ: AIFF), an Artificial Intelligence (“AI”) technology company developing innovative neuroscientific solutions that improve brain health outcomes for patients with mental illnesses and neurological disorders, today announced management will host a shareholder update call on Wednesday, September 4, 2024 at 5:00 PM Eastern Time.

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TAMPA, Fla., Aug. 22, 2024 (GLOBE NEWSWIRE) -- Inhibitor Therapeutics, Inc. ("Inhibitor") (OTCQB: INTI) today provided an update on development efforts for its itraconazole formulation for the treatment of Basal Cell Carcinomas in patients with Basal Cell Carcinoma Nevus Syndrome, otherwise known as Gorlin Syndrome. Inhibitor has allied with The Gorlin Syndrome Alliance and sought supportive guidance from the accomplished and highly-experienced members of its Scientific Advisory Board in efforts to pursue an expeditious path to acceptance by the U.S. Food and Drug Administration (FDA).

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WARREN, N.J., Aug. 22, 2024 (GLOBE NEWSWIRE) -- Tevogen Bio Holdings Inc. (“Tevogen” or “Tevogen Bio”) (Nasdaq: TVGN), a clinical-stage specialty immunotherapy biotech pioneer developing off-the-shelf, genetically unmodified T cell therapeutics in oncology, neurology, and virology, has entered into a definitive agreement for a $6.0 million Series C Preferred Stock investment with The Patel Family, LLP.

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TORONTO, Aug. 22, 2024 (GLOBE NEWSWIRE) -- PharmAla Biotech Holdings Inc. (“PharmAla” or the “Company”) (CSE: MDMA) (OTC:MDXXF), a biotechnology company focused on the research, development, and manufacturing of LaNeo™ MDMA and novel derivatives of MDMA (MDXX class molecules), is pleased to announce that it has created a new tool for researchers, providing direct access to its Chemistry, Manufacturing and Control (CMC) data – as well as its investigator’s brochure – to qualified researchers.

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NEW YORK and MAINZ, GERMANY, August 22, 2024 — Pfizer Inc. (NYSE: PFE, “Pfizer”) and BioNTech SE (Nasdaq: BNTX, “BioNTech”) today announced that the U.S. Food and Drug Administration (“FDA”) has approved the supplemental Biologics License Application for individuals 12 years of age and older (COMIRNATY® (COVID-19 Vaccine, mRNA)), and granted emergency use authorization for individuals 6 months through 11 years of age (Pfizer-BioNTech COVID-19 Vaccine) of the companies’ Omicron KP.2-adapted 2024-2025 Formula COVID-19 vaccine. This season’s vaccine is for use as a single dose for most individuals 5 years of age and older. Individuals 5 years of age and older with certain kinds of immunocompromise previously vaccinated with Pfizer and BioNTech COVID-19 vaccines or children under the age of 5 who have not already completed a three-dose series with previous formulas of a COVID-19 vaccine may be eligible to receive additional doses.

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SEATTLE, Aug. 22, 2024 (GLOBE NEWSWIRE) -- Adaptive Biotechnologies Corporation (Nasdaq: ADPT), a commercial stage biotechnology company that aims to translate the genetics of the adaptive immune system into clinical products to diagnose and treat disease, today announced it will be participating in the upcoming Morgan Stanley 22nd Annual Global Healthcare Conference in New York, NY.

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REDWOOD CITY, Calif., Aug. 22, 2024 (GLOBE NEWSWIRE) -- Seer, Inc. (Nasdaq: SEER), a leading life sciences company commercializing a disruptive new platform for proteomics, today announced that the company will be participating in the upcoming Morgan Stanley 22nd Annual Global Healthcare Conference in New York, NY.

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Posters to be presented highlight clinical study designs investigating pegtibatinase as the first potential disease-modifying treatment for classical homocystinuria Posters to be presented highlight clinical study designs investigating pegtibatinase as the first potential disease-modifying treatment for classical homocystinuria

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DEER PARK, Ill., Aug. 22, 2024 (GLOBE NEWSWIRE) -- Eton Pharmaceuticals, Inc (“Eton” or the “Company”) (Nasdaq: ETON), an innovative pharmaceutical company focused on developing and commercializing treatments for rare diseases, announced today that the Company will participate at the H.C. Wainwright 26th Annual Global Investment Conference in New York City.

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WINNIPEG, Manitoba, Aug. 22, 2024 (GLOBE NEWSWIRE) -- Kane Biotech Inc. (TSX- V:KNE; OTCQB:KNBIF) (“Kane Biotech”) will announce its second quarter 2024 financial results after market close on Thursday, August 29, 2024.

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Complete the form below to unlock access to this Audio Article: "What are Progenitor Cells? Exploring Neural, Myeloid and Hematopoietic Progenitor Cells"

Every cell in the human body, and that of other mammals, originates from stem cell precursors. Progenitor cells are descendants of stem cells that then further differentiate to create specialized cell types.There are many types of progenitor cells throughout the human body. Each progenitor cell is only capable of differentiating into cells that belong to the same tissue or organ. Some progenitor cells have one final target cell that they differentiate to, while others have the potential to terminate in more than one cell type.

Stem cells share two qualifying characteristics. Firstly, all stem cells have the potential to differentiate into multiple types of cells. Secondly, stem cells are capable of unlimited self-replication via asymmetric cell division, a process known as self-renewal.There are two broad categories of stem cells found in all mammals. The first are embryonic stem cells. These cells arise from the inner cell mass of the blastocyst in an early-stage embryo. Embryonic stem cells are the blueprint used to create every cell in the body. Because they can be used to create any type of cell, they are known as pluripotent.

The second type of stem cells found in mammals are adult stem cells (or somatic stem cells). Unlike pluripotent embryonic stem cells, adult stem cells are more limited in relation to the type of cells that they become. Unlike embryonic stem cells that could be used to create any cell, adult stem cells are limited to generating cell types within a specific lineage, such as blood cells or cells of the central nervous system. This level of differentiation potential is termed multipotent.

Stem cells create two types of progeny: more stem cells or progenitor cells. All progenitor cells are descendants of stem cells. When it comes to cell differentiation, they fall on the spectrum between stem cells and fully differentiated (mature) cells.

Whilst stem cells have indefinite replication (left) progenitor cells can at most differentiate into multiple types of specialized cell (right).

Function:

Cellular repair or maintenance

Cell Potency:

Multipotent, oligopotent, or unipotent

Self-renewal:

Limited

Origin:

Stem cells

Creates:

Further differentiated cells (either progenitor cells of mature/fully differentiated cells)

Progenitor cells are an intermediary step involved in the creation of mature cells in human tissues and organs, the blood, and the central nervous system.

The human central nervous system (CNS) contains three types of fully differentiated cells: neurons, astrocytes and oligodendrocytes. The latter two are collectively known as glial cells.Every neuron, oligodendrocyte and astrocyte in the CNS evolves from the differentiation of neural progenitor cells (NPCs). NPCs themselves are produced by multipotent neural stem cells (NSCs). Both NPCs and NSCs are termed neural precursor cells.Before the 1990s, it was believed that neurogenesis terminated early in life. More recent studies demonstrate that the brain contains stem cells that are capable of regenerating neurons and glial cells throughout the human lifecycle. These stem cells have only been found in certain brain regions, including the striatum and lateral ventricle.

Hematopoietic progenitor cells (HPCs) are an intermediate cell type in blood cell development. HPCs are immature cells that develop from hematopoietic stem cells, cells that can both self-renew and differentiate into hematopoietic progenitor cells. HPCs eventually differentiate into one of more than ten different types of mature blood cells.Hematopoietic progenitor cells are categorized based upon their cell potency, or their differentiation potential. As blood cells develop, their potency decreases.

First, hematopoietic stem cells differentiate into multipotent progenitor cells. Multipotent progenitor cells are those with the potential to differentiate into a subset of cell types. These cells then differentiate into either the common myeloid progenitor (CMP) or common lymphoid progenitor (CLP). Both CMPs and CLPs are types of oligopotent progenitor cells (progenitor cells that differentiate into only a few cell types).

CMPs and CLPs continue to differentiate along cell lines into lineage-restricted progenitor cells that become final, mature blood cells.Myeloid progenitor cells are precursors to the following types of blood cells:

Lymphoid progenitor cells (also known as lymphoblasts) are precursors to other mature blood cell types, including:

The primary role of progenitor cells is to replace dead or damaged cells. In this way, progenitor cells are necessary for repair after injury and as part of ongoing tissue maintenance. Progenitor cells also replenish blood cells and play a role in embryonic development.

Neural progenitor cells (NPCs) are being explored alongside neural stem cells for their potential to treat diseases of or injury to the central nervous system. A deeper understanding of how these cells function on a cellular and molecular basis is needed to progress from early experimental research to therapeutic use.NPCs are currently utilized in research conducted on CNS disorders, development, cell regeneration and degeneration, neuronal excitability, and therapy screening. When compared to induced pluripotent stem cells, which are cells reprogrammed into a pluripotent state, NPCs can cut down on time in some experiments.Hematopoietic progenitor cells and stem cells are being researched for their capacity to treat blood cell disorders. They are also currently used to help treat patients with a variety of malignant and non-malignant diseases via bone marrow transplants that deliver bone marrow and peripheral blood progenitor cells to patients. These procedures can assist patients in recovering from the damage caused by chemotherapy.Additionally, researchers are examining the potential of using progenitor cells to create a variety of tissues, such as blood vessels, heart valves, and electrically conductive tissue for the cardiovascular system.

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What are Progenitor Cells? Exploring Neural ... - Technology Networks

Somehow time has flown by so that Ive been around for ages in the stem cell universe and some unproven stem cell clinic type firms, like the well-known Panama stem cell clinic that sells autism treatments, are also long-timers.

Its been an odd parallel existence for more than a decade.

Todays post is focused on this Panama stem cell clinic. Think of it as a fact-check or a scientific review of a sort. Overall, I believe there are serious reasons for concern about The Stem Cell Institute.

Long-time stem cell clinics | The Stem Cell Institute in Panama | What they sell | Who works at The Stem Cell Institute? | Lack of expertise & specialty training? | Lack of data | Cost of stem cell therapy in Panama $16,000-$30,000 and up | Take home message | References

Quick Article Summary and Claim Review.Stem cells are a still unproven approach to autism and other conditions. The Stem Cell Institute in Panama claims that umbilical cord stem cells can help autistic children and people with other conditions. In my view there are no strong data to support this claim, particularly on autism. The most rigorous study to date by Duke suggests no consistent benefit. There are definite risks too and the procedures are expensive. You should consult your childs pediatrician.

Both the Panama clinic place, run by Neil Riordan and called simply enough The Stem Cell Institute, Texas stem cell clinic Celltex, and the Regenexx clinic brand come to mind in this long-termer category. These three firms are quite different though. Ive written many times before about Celltex and a bit aboutRegenexx, but less so about The Stem Cell Institute. My most recent item on this Panama place was related to the puzzling threads between them and the Duke Autism Program.

There are stem cell clinics all over the world, but some draw more attention and customers than others. I also view some as posing potentially higher or lower risks on different levels.

The Stem Cell Institute in Panama strikes me as risky on some specific levels such as having many children getting unproven cellular injections as part of their business model. This place seems particularly successful with their PR too.

I dont know about you, but for me the name institute implies a non-profit research institution, but to the best of my knowledge The Stem Cell Institute is a for-profit. While it does some research, I dont see that as its primary mission.

The Stem Cell Institute offers injections for a wide menu of health conditions using umbilical cord and other kinds of cells. You can see a screenshot I took from their website recently to get a sense of their marketing.

Its strikingly diverse, raising the question for me of how one place can purportedly have the expertise to try to treat so many different conditions.

To cover all of these conditions with care and expertise Id say that youd need a neurologist, an immunologist, an orthopedist, a cardiologist, and pediatric physician specialists of several kinds.

Do they have the needed medical staff with board certifications in so many different specialties?

In regard to the above question, who are the doctors and other staff at the Panama stem cell clinic?

Last I checked their website, they listed 7 physicians in total including a medical director, a clinical trials research physician, and staff physicians.

Only the first 3 doctors listed have bios describing their training. Do they have the needed expertise?

Of these 3, the Medical Director, Jorge Paz-Rodriguez, MD, appears to be an internist. Hernan H. Hernandez, MD may be a hematologist. Dr. Cindy Leu may be a general practitioner. I wasnt able to clear up if she has a specialty.

The clinical trials doctor listed, Giselle Fernandez, MD, also might be a GP, but Im not positive. As to the staff physicians, I was not able to determine if they have any specialties or are GPs despite looking around on the web and watching some videos. Leader Neil Riordan is a Ph.D., not an M.D.

Overall, as a result of the lack of information and the nature of what I could find, in my opinion, it does not seem like this clinic clearly has the needed expertise to treat so many medical conditions and patients ranging from pediatric to geriatric. In my view, this increases risks for patients.

If these Stem Cell Institute physicians have more specialty training than I could find, I will update this post.

I also view the offerings of The Stem Cell Institute as lacking in rigorous data to back them up. Neil Riordan has some publications, but the research in these papers relevant to what they are selling is not convincing at all to me. It does not show that the stem cell offerings, such as umbilical cord MSCs, actually work. The papers also do not indicate that they are definitely safe for the conditions being marketed.

The clinical studies generally do not have placebo controls, randomization, or double-blinding. If you are developing an as yet unproven cellular therapy, it may be fine to have early phase trials without placebos, etc., but if you are already marketing and injecting folks with this unproven stuff and charging for it, its an entirely different situation. The Stem Cell Institute seems to me to be putting the cart before the horse. Note that while others have done research on cord blood cells for autism including Duke, the data are generally very discouraging.

It is expensive to go to the Stem Cell Institute. Their own website mentions the cost as follows, $15,825 USD for children and $23,150 for adults. An important paper this year in Cytology by Jeremy Snyder and Leigh Turner, focusing in part on reverberations between the Stem Cell Institute and Duke, also discussed cost and fit into this general price range.

Like many stem cell clinics abroad and even in the US, the cost often ends up being a package including a hotel stay and ground transportation.

There are also many fundraising campaigns on GoFundMe that mention Panama stem cells and sometimes include patients mentioning about what they paid. All of this is generally consistent with a price range of $16,000-$30,000.

As with other clinics, the cost can go much higher than what is stated. Factors influencing cost include the number of injections and the type of condition. If you get several injections or go on multiple occasions over the course of months or years, the costs can go way up, even into the high tens of thousands.

Also, one should factor in the odds of attaining success in the medical condition that is the problem and with unproven stem cells the odds of real documented success in my view are very low. Then there are risks as well.

Overall, in my view there is a low probability of efficacy from what is being sold at this firm in Panama and we cant be sure about safety. At least some of the cells being sold are amplified in a lab, potentially increasing safety risks. As I said earlier, I also worry about the apparent lack of relevant (and Id say crucially needed) medical specialty training.

As a Ph.D. I cannot give medical advice, but as a stem cell biologist and long observer of clinical research in this arena as well as of unproven stem cell clinics, I personally would not go to this clinic or have a friend or loved one go.

If you have complaints about the Stem Cell Institute in Panama Id like to learn more about what your concerns are.

Crowdfunding, stem cell interventions and autism spectrum disorder: comparing campaigns related to an international stem cell clinic and US academic medical center, Jeremy Snyder and Leigh Turner, Cytology, March 2021.

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I took a look again into the world of stem cell supplements since its been a few years.

What I found now in 2022 wasnt a pretty picture. This post has several sections so feel free to jump to sections below. Ive also done a new YouTube video on stem cell supplements that goes through the main points to consider. If you like the video please subscribe to our channel.

Supplements in general | Stem cell supplements claims| Supplement ads and products| Visiclear & Visishield | Stem-Kine | Regenexx supplements | Big picture on stem cell pills

Quick Article Summary and Claim Review.Stem cells have generated a lot of buzz, only some of it legitimate. Stem cell supplements and their makers claim that these pills or drinks will improve your health via impacting your stem cells. My research indicates there are no strong data to support any of these claims. Stem cell supplements also could have risks. Since they are also very expensive, as a stem cell biologist I recommend against taking stem cell supplements, but you should consult your physician.

Note that supplements here refer to things people can ingest to somehow supposedly help their stem cells, not supplements that us scientists add to the media we use to grow stem cells.

For context, Im fairly skeptical of supplements in general unless one has a documented deficiency in something like iron or maybe (maybe not) Vitamin D, or if you are vegan maybe you should take B12.

As a 10+ year prostate cancer survivor the only supplement I take still is in fact Vitamin D, but Im having my doubts even about that. Ten years ago it made sense to me theoretically that a hormone like Vitamin D might help prevent cancer recurrence based on in vitro results growing cancer cells in a dish, but the literature hasnt been very encouraging on any benefit in actual people. Im mulling it over.

The idea of zinc supplements given right at the beginning of colds has been controversial but a new study this year gives some weight to it perhaps shortening the length of colds.

I more recently went through the supposed brain supplement Prevagen and found reasons to be concerned about their advertising claims and also about potential risks.

So what about supplements claiming some link to stem cells?

Theres not much foundation for them and they cost a bundle.

The main claims of these supplements is that theyll either make you as a patient have more stem cells, happier stem cells, or aid in stem cells differentiating into the desired cell type. Other claims include anti-inflammatory and anti-aging properties

A big surprise for me was that searching Clinicaltrials.gov finds many studies of the effects of specific supplements on stem cells, but little data. One that did have data was focused on a supplement called NutraStem and tested its effects on CD133+ or CD34+ cells as compared to a placebo. It didnt seem to work.

There is no evidence of supposed stem cell eye supplements benefiting eyes or vision either.

A Google search for Stem cell supplements yields an array of results and ads.

While Google has rightly (and generally very effectively) banned stem cell clinic ads, it still feels like anything goes with stem cell supplement ads. You can see a screenshot above for some results. An Amazon search yields tons of overlapping and sometimes wild results too, some approaching a thousand dollars a pop.

Take a look at a grassfed bone marrow (Im imagining a test tube of living bone marrow with someone trying to feed it grass) supplement claiming to have something to do with stem cells:

Contains all the nutrients, specialized cells (including stem cells and base cells), collagen, growth factors, fat soluble activators and substances that the body uses to build, repair, and maintain all tissues

I doubt there are living stem cells in there. And, what are base cells? Basal cells?

Ive been hearing more about two vision-related supplements called Visiclear and Visishield.

These supplements contain vitamins, antioxidants and other factors. Various claims on the web suggest that these products may help vision by either keeping stem cells healthy or restoring stem cell health.

Im skeptical.

While we stem cell researchers do sometimes add vitamins or antioxidants to our cultures of stem cells in the lab, its not clear that antioxidants that people eat or take as supplements would have benefits to endogenous stem cells, including in the eye.

A quick search on Amazon found that these products are also very expensive. There are quite a few unhappy customers who left reviews there as well.

One purported stem cell-related product that pops up often on Google searches is something called Stem-Kine from Neil Riordan, who runs a stem cell clinic firm in Panama. A decade ago he published some on Stem-Kine claiming a link to mobilizing stem cells, but Im not convinced at all.

Physicians in the hospital can reproducibly mobilize stem cells in donors or patients but this is done using powerful, proven drugs, and has been the subject of tons of published research such as related to preparing stem cell transplants after chemo in cancer patients. (By the way, you might find this guest post on a familys experience with stem cell donation to be an interesting read.)

These supplements are super expensive too. How much does Stem-Kine cost? For a case of 60 x 700mg capsules on Amazon youll pay about $70, which seems ridiculous to me.

But could it work?

Its hard to say without more data, but I doubt it and anything like this has risks too.

Further, its not clear that mobilizing bone marrow stem cells in a healthy patient on a regular basis is a wise thing to do.

Check out the comments from Wise Young in the comments section for another view.

The Regenexx brand has a whole supplement product line now including Regenexx Complex. One supplement, called Advanced Stem Cell Support Formula costs about one hundred bucks for 32 fluid ounces which is about $400 a gallon.

The description says its a proprietary blend of vitamins, herbs, and supplements that may help support healthy stem cell function and cartilage production.

The Amazon page for this or a very similar product lists these ingredients: Vitamin C 1000mg, Vitamin D 2000IU Proprietary Blend 3455 mg of Glucosamine Sulfate and HCl, Chondroitin Sulfate, Curcumin, L-Carnosine, Resleratrol (resVida), Bitter Melon, BioPerine Does not contain wheat, gluten, sugar, soy or dairy. Contains ingredients derived from shellfish and corn.

Is there any published clinical data to back up this expensive supplements use in people? Not that I could see. I dont see a good rationale for Regenexx Complex either.

Note that Advanced Stem Cell Support Formula comes in citrus or strawberry banana flavor. A good-sized Jamba juice with fresh strawberries and bananas, and a boost of some vitamins in it costs about $6 or $7. I havent had one of those in years, but they sound good even if rather full of sugar.

Overall, in my view stem cell supplements are not worth the money, probably wont do anything terribly exciting in a positive way, and could have risks. You can watch a Q&A YouTube video I did below in which one question and answer was related to stem cell supplements.

Note that I actually had an old post (Top 5 possible natural stem cell boosts) on possible simple ways to possibly boost stem cell numbers in a more general sense, but admittedly even these ideas are speculative and do not involve supplements or paying money. For example, try to sleep a healthy amount and especially exercise more in certain ways.

At this point in my view exercise seems like maybe the only possibly reliable and safe way to impact certain kinds of stem cell numbers in your body.

Well see in coming years or decades if any specific supplement can convincingly do something useful that is stem cell-related based on more research. Its also important to consider that anything that boosts stem cell numbers could also pose the risk of unwanted consequences like abnormal cell or tissue growth.

Will there ever be a stem cell pill that one can take to somehow improve your stem cells in numbers or function in a safe way that positively impacts specific aspects of your health? Well see but right now there is nothing like that.

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2022. 8. 12. The high rates of chronic, ... (A Center for Anti-Aging and Regenerative Stem Cell Therapies) Whether to be treated for pathological conditions, ... DOH: 4 PH hospitals allowed to do stem cell therapy one of them is the Asian Stem Cell Institute Details News. Hits: 4058. STEM CELL PHILIPPINES All our products are 100% Singapore-made and we're the only legitimate STEM CELL provider in the Philippines. Our product is created with a highly sophisticated formula that's scientifically proven to give you the best source for viable stem cells available in the market. Order Now! Salamat STEM CELL PH!!!. Stem Cell Therapy in Asia Hospitals and medical centers in Asia offering stem cell therapy. ... A JCI accredited multi-specialty medical institute which has been serving patients from the Philippines and all over the world for over a century. It has over 600 inpatient beds and 1,700 affiliated medical consultants.

Check out the best packages for stem-cell-therapy-for-osteoarthritis in manila-metro, philippines. Compare prices, clinics and choose the right package for your procedure.. Stem cell therapy aims to repopulate the cells in the degenerative disc and restore functional tissue through matrix synthesis by implanted cells and beneficial influences on native cells. Adult stem cells, or MSC's, have been proposed as the ideal source for disc regeneration. An increasing number of studies have demonstrated the ability of.

Here are some highlights. The self-reported responses on cost for stem cell treatments, as indicated by respondents to our 2020 polling, suggest the price has gone up. While the most common answer in 2019 was $2,501-$5,000, in 2020 the most common response was $10,001-$20,000, while $2,501-$5,000 was close behind. Motions Venture Physio Therapy Inc. Motions Venture Physio Therapy Inc., located in Butuan, Agusan del Norte, Philippines offers patients Stem Cell Treatment for Tennis Elbow procedures among its total of 55 available procedures, across 7 different specialties.

Future Directions in Stroke- Stem Cell Therapy. The treatment can cost anywhere from $125,000 to $200,000 depending on if the patients experience any complications. Every patient is different, Hodson said. There is also a risk Hodson will not be chosen to receive a stem cell transplant .. Future Directions in Stroke- Stem Cell Therapy. The treatment can cost anywhere from $125,000 to $200,000 depending on if the patients experience any complications. Every patient is different, Hodson said. There is also a risk Hodson will not be chosen to receive a stem cell transplant ..

The price of a Stem Cell Therapy can vary according to each individuals case and will be determined based on photos and an in-person assessment with the ... Some other countries, such as China and the Philippines, need a visa to visit the country. All visitors need to hold a passport valid for at least 3 months. Weather in. Compare the cost of... Bone marrow transplant. Cellular immune therapy. Hip / Knee regenerative treatment. Stem cell treatment.. Future Directions in Stroke- Stem Cell Therapy. The treatment can cost anywhere from $125,000 to $200,000 depending on if the patients experience any complications. Every patient is different, Hodson said. There is also a risk Hodson will not be chosen to receive a stem cell transplant ..

Future Directions in Stroke- Stem Cell Therapy. The treatment can cost anywhere from $125,000 to $200,000 depending on if the patients experience any complications. Every patient is different, Hodson said. There is also a risk Hodson will not be chosen to receive a stem cell transplant ..

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Your gut is a wondrous place. A special layer of cells that coats the insides of your small and large intestines takes in nutrients and water from what you ate while keeping anything bad out of your system. This layer is called the intestinal epithelium. It completely renews itself every four to seven days using stem cells. These are a special cell type that can both self-renew by dividing and differentiated to give rise to any other types of cells to renew your organs. Scientists still do not know how exactly they make these decisions however, or what defines a stem cell.

Bernat Corominas-Murtra, previously postdoc at the Institute of Science and Technology Austria (ISTA) and now assistant professor at the University of Graz, and Edouard Hannezo, professor at ISTA, worked together with an international group of experimental researchers led by the Jacco Van Rheenen team in Amsterdam to study the stem cells in the intestinal epithelium. They found an exciting new mechanism that could change our understanding of what a stem cell is.

The intestinal epithelium is just one layer of cells thick and constantly renewed. It is all over the villi which look like tiny tentacles covering the insides of the small and large intestines. Between the villi, there are tiny pockets in the tissue called intestinal crypts. That name may invoke some mystery and that may be not too far off what really happens there. At the bottom of the crypts, stem cells in the epithelium are constantly dividing. Some of the resulting cells remain as stem cells in the crypt and the others are pushed outwards towards to tip of the surrounding villi, Corominas-Murtra explains, there, in the end, they differentiate into functional cell types that allow intestinal function and which are discarded after a few days. This happens all the time inside your body and if this mechanism breaks down, you can get into serious medical trouble.

While studying these stem cells in the small and large intestines, the scientists were initially perplexed. How we usually think of stem cells is that being a stem cell is determined by intrinsic biochemical properties of a cell something like a biochemical marker we can identify, Corominas-Murtra continues. We found that among the cells that had this traditional stem cell marker, many of them never actually worked as stem cells but were pushed out of the crypts to be discarded instead, without contributing at all to the long-term renewal of the gut. We also saw that while classical markers predicted about the same number of stem cells in both the small and large intestines, there were about twice as many of them actually working as stem cells in the small intestine than in the large intestine. The scientists therefore wanted to understand what determines which cells actually act as stem cells and they found a surprising new mechanism that regulates the stem cells in the crypts.

We found that whether these cells behave as a stem cell or not is all about their location! Cells in the epithelium are not just pushed outwards from the crypt by the cell divisions below them like on a conveyor belt but there is another kind of motion involved, Corominas-Murtra explains. The scientists found that cells in the epithelium layer also actively move around in random directions back and forth along the conveyor belt if you will. This way, cells that were already pushed along the conveyor belt for a bit can end up back at the base of the crypt, and act there again as stem cells to divide and replenish the epithelium. Edouard Hannezo explains the possible implications of these findings, These movements constitute a new environmental mechanism that determines which cells get to functionally act as stem cells. In the small intestine, the molecular signal regulating the movements is stronger than in the large intestine, so cells can move more frequently back into the crypt. This explains why there are more actually working stem cells in the small intestine than in the large ones. This could have major implications for our understanding of what a stem cell actually is and how to use them in medical applications.

This insight builds on previous research by Bernat Corominas-Murtra and Edouard Hannezo at ISTA and the work of the Van Rheenen group. Originally coming from a physics background, Corominas-Murtra and Hannezo created an advanced mathematical model of the intestinal epithelium layer which included the motion of the cells both away from and back towards the crypt. Using their model, they could predict the number of actually working stem cells in the small and large intestines. A number of other research groups from all around Europe designed experiments using the latest methods in microscopy and genetics to test the predictions and found them to be accurate. They even tried to inhibit the chemical signal in the crypts and saw that this reduced the number of working stem cells as predicted.

Reference:Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, et al. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 2022. doi: 10.1038/s41586-022-04962-0

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New Stem Cell Mechanism Discovered in Intestinal Epithelium

Joe Rogan first popped up more squarely on my radar screen years ago because of a concerning video thats out there of him talking with Mel Gibson about stem cells.

At the time it was one of the most-watched videos on YouTube on stem cells.

I took apart thatstem cell video and its claims including related to a Panama stem cell clinic, which in my opinion were way out there. It seems to me that the video was likely encouraging everyday people to take risks for themselves and their families at the clinics.

I thought at the time that maybe that was that.

However, it turns out that Joe Rogan is still really into stem cells. There are many videos out there of him talking with celebrities about stem cells. In addition to Mel Gibson, he has also talked stem cells with former boxer Mike Tyson (see above), rapper Action Bronson, MMA fighter Henry Cejudo, and quite a few others. In some of the videos, Rogan is talking about his own experiences.

The clip promoting the clinic Bioxcellerator ends with Rogan saying, Yeah, its real shit man about the stem cells.

So whats the big deal?

One problem is that the stem cell content on his show encourages risk-taking by the public. The supposed stem cell treatments arent based on solid, consistent data and they focus largely on anecdotes.

As with the Mel Gibson video, in the other videos Joe also often seems to promote specific unproven clinics. Theres no balance in the interviews. I havent watched all the Rogan videos mentioning stem cells but much of the content feels like advertising to me. Like infomercials.

Searching for Joes name and stem cells on the web under videos on Google or on YouTube and youll easily see much of this content.

Strikingly, some of the clips were uploaded to YouTube by the unproven stem cell clinics mentioned in the videos.

If nothing else this tells us that the clinics view the videos as promotional material. Does Rogan get paid for some of this? Or maybe he gets a discount or free treatments for himself or his family?

Who knows, but these are important questions. He might just be extremely enthusiastic about stem cells without some compensation.

Has he ever had a physician doing legit stem cell-related clinical trials on his show too? If so, I havent seen that.About the closest thing is a 2020 interview with Aubrey De Grey, which Ive included above. Theres some sober discussion in there from Aubrey, but unfortunately, its mixed in with Rogan going on about stem cell clinic offerings. Aubrey has a somewhat more relaxed view about stem cell tourism than I do, but you can tell from this video and other talks that Ive seen him give that he still wants to see all the data.

Moving forward, Rogan could do some good by bringing attention to strong stem cell clinical trials and advocating for a data-focused approach. Thats not likely. In the bigger picture, there are some major concerns about Joe Rogans statements about COVID-19and other health issues as well.

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A North Lanarkshire couple have tied the knot after the groom was given a devastating terminal cancer diagnosis just weeks ago.

Julie Neilson and Michael Duffy, who are parents to five girls, got engaged last Christmas Eve.

While couple had planned to get married in 2022, Michael was given shocking news that he had secondary cancer in his liver in December.

READ MORE: Get the latest news from Glasgow Live here.

Doctors told the 44-year-old machinist he had 'weeks to months' to live, the Daily Record reports.

Without wasting anymore time, the Airdrie couple got married yesterday with their children at Celtic Park as a tribute to Michael's favourite team.

One of those who will watch Julie walk down the aisle is eight-year-old daughter Ava, who has stage five cerebral palsy and a range of other medical conditions which are also sadly terminal.

Julie, 41, told the Record before the big day: "It feels amazing that after all this time it has finally happened.

"It still hasn't sunk in yet and I think it will take a while for both me and Michael to settle down and let it all sink in.

"It's all been non-stop with dresses and make-up artists today, Michael had to sneak out of the house at 9am to go to his pals so he wouldn't see my dress.

"I've been keeping it hidden from everyone - not even the bridal party got to see my dress until I went down the aisle."

The couple set about the task of organising their dream wedding in just over three weeks - so this Christmas period has been the busiest of all.

Julie said: "It's been a very busy couple of weeks.

"On December 5 we were given the news that Michael had secondary adenocarcinoma of the liver.

"It has an unknown origin. The doctors can't find the primary cancer because Michael's own immune system has actually managed to fight that off.

Have your say on this story in the comments section.

"But part of the cancer has broken away and attacked his liver.

"The doctors have said it is very aggressive and he just has weeks to months.

"Michael proposed to me last Christmas Eve and we've been together for four years but we have known each other most of our lives.

"He was my high school crush and it's just unbelievable this has all come together."

Julie and Michael have been supported by the Wedding Wish Makers charity and generous donations from loved ones and well-wishers to help create their dream big day.

But there was only one venue that would do for Celtic fan Michael.

Julie said: "Michael is a big Hoops fan, I don't know that much about football but I like to help out with his predictions.

"It has been hard to organise with all the hospital visits and Michael's diagnosis being so new.

"But I'm used to it because my daughter Ava is medically complex and terminally ill. She has level five cerebral palsy and is medically fragile, it means she requires 24/7 care.

"She can't swallow properly and has to be fed through a button in her stomach.

"So when Michael was given his news it was especially devastating- he has been my support and helped me get through it all."

With the pair now married, Julie says they are not giving up hope yet.

They managed to get stem cell treatment for Ava in Panama around five years ago that has improved her quality of life, and Julie hopes to find treatment for Michael.

She said: "We are looking at all sorts of different options and seeing if there is anything we can do to slow down his condition or somewhere we can get a better variety of treatments.

"We are not giving up yet. We are fighters."

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Couple marry at Celtic Park after groom told he has only weeks to live - Glasgow Live

Asia-Pacific now ranks in first for the total number of trials taking place, compared to its fourth-placed ranking in 2010. Credit: Shutterstock

The Asia-Pacific region has seen a 158% increase in the number of musculoskeletal disorders trials taking place over the past decade, the largest increase for any region worldwide.

The region now ranks in first for the total number of trials taking place, compared to its fourth-placed ranking in 2010.

These figures come from GlobalDatas extensive clinical trials database which seeks to track the number of clinical trials taking place in countries around the world, in numerous therapy areas.

The Asia-Pacific region saw the biggest increase in musculoskeletal disorders related trials.

Between 2010 and 2020, there was a 158% increase in the number of trials taking place.

In 2020, the largest proportion of trials in the region took place in China with 46.5% of all trials in the region taking place there.

India and South Korea had the next largest percentage of trials taking place in the region with 19.2% and 7.3%, respectively.

The Middle East saw a 142% increase in the number of musculoskeletal disorders trials taking place.

Iran saw the largest amount of trials taking place, in 2020, at 76.1%.

Trials in Saudi Arabia and Israel also made up a large proportion of the trials taking place with 13% and 6.5%, respectively.

Africa saw a 100% increase in the number trials taking place.

Egypt, South Africa and Zimbabwe made up the most trials in the region, with 75%, 10% and 5%, respectively.

North America saw a 15% increase in musculoskeletal disorders related trials taking place.

The United States saw the largest percentage of trials taking place in the region at 87.6%.

Canada and Mexico also made up a significant proportion of the trials taking place.

Europe saw a decrease in the number of musculoskeletal disorders trials.

The region saw a 40% decrease in the number of trials.

Russia made up 10.3% the largest proportion of trials taking place in the region.

Spain and the United Kingdom also made up a large amount of the trials taking place with 9.6% and 8.9%, respectively.

South and Central America saw the biggest decrease in musculoskeletal disorders trials.

The number of trials in the region fell by 50% between 2010 and 2020.

Brazil saw the largest percentage of trials taking place in the region with 50%.

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A former junior motorsport racer with multiple sclerosis who battled against the odds to receive experimental stem cell treatment in Panama in April is already noticing improvements in his condition.

Alister Bailey, 39, a former Barnes resident, travelled to the Stem Cell Institute with his wife Gemma, despite warnings they would not be let in to Panama due to coronavirus travel restrictions.

MS is an autoimmune disease that can affect the brain and spinal cord. Common symptoms include mobility problems, vision problems, muscle spasms, fatigue and speech difficulties.

Before Panama, Alister couldnt hold a cup of tea, but now his hands have stopped shaking and he can pour a drink without spilling it. He has also noticed an improvement in his eyesight.

Gemma said: This might seem trivial but its a huge physical change.Thats a really positive sign and certainly encouraging for us in terms of the next round.

We have seen some positive signs already which is amazing because we didnt really have any expectations this time round to be honest; it was more to stop the deterioration.

He really believes it will work and he feels something is happening.

The Baileys are currently fundraising to get Alister back to Panama for a second round of treatment in November.

The pair were supposed to fly out to Panama for the first round in January after raising 22,500, but coronavirus put a stop to those plans.

Travel restrictions meant they had to delay the trip until the end of April but, even then, it was not an easy ride.

Read below about their rollercoaster journey:

The pair opted for experimental mesenchymal stem cell therapy because treatment options for progressive MS are limited.

A year after he married Gemma, Alister started experiencing episodes where he wasnt able to walk and then he went blind for two days in 2012.

Since receiving his diagnosis, Alister has been on a drug for ten years to slow symptom progression. But Gemma said his condition has rapidly deteriorated in the past three years. While he does not use a wheelchair at home, he cannot walk any long distance unsupported.

She said: Theres no cure for progressive MS so this treatment in Panama is his only hope.

Alister didnt qualify for anything on the NHS which was pretty disheartening.

We have various doctor friends, some of them researching stem cell treatments for different illnesses but they said this is where medicine is going in the future.

The Stem Cell Institute administers mesenchymal stem cells (MSCs) which are recovered from donated umbilical cords and grown in labs.

MSCs are adult cells which can produce other cells like muscle. This is why researchers are interested in testing whether they can protect nerves from more damage and repair the original damage.

The Baileys are hoping to see the best benefits of the treatment after two or three rounds and have prepared themselves for potentially five visits.

They have planned fundraising events to get together the funds needed for November.

On 17 July, Alisters 67-year-old dad Chris took on the Surrey Hills Epic Off-Road Challenge which involves 125km of off-road mountain biking.

Gemma is organising a charity dinner and her friend Claire is running the Lulworth Cove Trail Challenge which involves running along the coastline.

Their friend Jonny Wright has already raised $14,400 as he prepares to cycle 2,500 miles from Maine to Florida in 30 days starting on 27 August.

Their hope is that the treatment will stimulate repair of the damaged tissues so that Alister can play football with his son again.

You can follow the familys journey on their Instagram page.

You can donate to their fundraiser here.

Credit for all photos: Gemma and Alister Bailey.

See the original post here:
Dad with multiple sclerosis who fought for treatment in Panama during Covid restrictions finds first round is 'reaping rewards' - South West Londoner

Multiple sclerosis is an autoimmune disease that can affect the brain and spinal cord, and it is estimated that 130,000 people in the UK have the condition.

There are drugs available to slow the onset of symptoms but treatment options for progressive MS are limited and there is currently no cure.

At the end of July, the US Food and Drug Administration authorised a Phase 2 clinical trial at Hope Biosciences Stem Cell Research Foundation in Texas.

The future of MS treatment is exciting; scientists think solutions for all types of MS could be in their late stage trials by 2025.

But what are the options for those living with progressive MS right now? Some are desperate to halt their symptom deterioration.

Increasingly, they are looking to experimental treatments like the one offered by Panamas Stem Cell Institute.

Alister Bailey and Liam Egalton both raised tens of thousands of pounds to travel to Panama for mesenchymal stem cell therapy. To find out about their turbulent journeys during the pandemic and learn more about ongoing MS treatment research projects, read the full story here:

https://swlondoner.shorthandstories.com/multiple-sclerosis-and-the-experimental-treatment-giving-families-hope/index.html

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Multiple sclerosis and the experimental treatment giving families hope - South West Londoner