StemCell Therapy

WHAT IS KIDNEY

Kidneys are a pair of bean-shaped organs that lie in abdominal cavity. It is essential in the urinary system and also serve homeostatic functions such as the regulation of electrolytes, maintenance of acidbase balance, and regulation of blood pressure (via maintaining salt and water balance). They serve the body as a natural filter of the blood, and remove wastes which are diverted to the urinary bladder. In producing urine, the kidneys excrete wastes such as urea and ammonium.

Chronic kidney disease occurs when one suffers from gradual and usually permanent loss of kidney function over time. With loss of kidney function, there is an accumulation of water; waste; and toxic substances, in the body, that are normally excreted by the kidney. Loss of kidney function also causes other problems such as anemia, high blood pressure, acidosis (excessive acidity of body fluids). Although the major causes of chronic kidney disease are diabetes and hypertension. The stage-5 patient is called end stage or chronic kidney disease patient.

Table 1. Stages of Chronic Kidney Disease

*GFR is glomerular filtration rate, a measure of the kidneys function

The kidney is a highly complex organ, composed of more than 30 different cell types in different compartments, such as tubular epithelial cells, interstitial cells, glomerular cells and cells of the vasculature. Currently the CKD patients are increasing worldwide and there is no appropriate treatment available for chronic kidney disease. So based on successful experiment on the animals & humans, now researchers are hopeful of its application on human being.

Chronic kidney disease causes dysfunction of the cells from vascular, interstitial, glomerular and tubular compartments which triggers the release of fibrogenic cytokines and recruitment of inflammatory cells to injured kidneys. The rapid interposition of scar tissue probably confers a survival advantage by preventing infectious microorganisms from invading the wound, but prevents subsequent tissue or renal cell regeneration.

Stem cell transplantation into CKD patient may provide improvement like reduced creatinine level because stem cells like mesenchymal stem cell has the property to differentiate into renal specific cells such as nephron, tubular epithelial cells, nephron and others. After infusion of stem cells into the CKD patients via using catheterization into the renal artery, then start to regenerate the damaged/injured renal tissue and also induce/activate resident stem cells in the renal via para/autocrine signaling. Stem cells therapy provides better environment to regenerate the damaged cells via differentiating into the renal specific cells and also induce the resident stem cells. Otherwise patients require 1-2 tabloids to achieve good stem cell dose in our body because stem cell supplement work similar to stem cell therapy.

Stem Cell Treatment which can be given via multiple injection in the selective hospitals/clinics at very huge cost (10,000-25,000 USD) but stem cell supplement which can be shipped in secure packages and delivered right to your home at very affordable price than stem cell transplantation.

Basically we have two types of stem cell supplements which work equally as stem cell therapy. Get more detail on our all two types of stem cell supplement in detail:-

1 Sheep Placenta derived Tabloids: Placenta derived stem cell supplement which has been made first time in Switzerland and manufactured under the FDA approved and cGMP registered Pharmaceutical Facility here in the United States which obtains trust with maximum quality, safety and consistency. This is the only Stem Cell Supplement product in world which is made by sheep stem cells (tabloid form) through Dry Freezing Technology (patented method). Sheep placenta tabloid delivers stem cells at good amount which remain biologically active (using a proven technique for gently conserving biological substances) without damaging the effectiveness of their valuable bioactive matter and it can be shipped in secure packages and delivered right to your home. Being enteric coated this softgel tabloids dissolve in the small intestine whereby the stem cells and other active ingredients are fully absorbed by the body. To get better results and benefits of this supplement, we prescribe to take 1 3 softgel tabloids in one day.

2 Stem Cell Worx: Another supplement Stem Cell Worx (Intaoral spray) is natural dietary health supplement which contain some natural ingredient (Bovine Colostrum, Trans Resveratrol & Fucoidan) which is helpful to increase the circulation of stem cells in the body for an extended period of time and help to make your body healthy and disease free for a long time. This supplement activates your own adult stem cells naturally and provides robust immunity and stimulates your bodys natural repair system.

Stem cell may reduce/maintain serum creatinine level in end stage/chronic kidney patient for a long time but there is no assurance that it may be alternative of kidney transplant in future after stem cell therapy. As kidney transplant success rate is not 100% in kidney failure patient and some patient may get again kidney related problem even after kidney transplant because of the usage of immunosuppressant drug for a long time so if patients who already got kidney transplant and again facing kidney disease then such type of patients also may get stem cell therapy because It may reduce/maintain serum creatinine level and also reduce the immunosuppressant drug dosage because mesenchymal stem cell has the immune-modulation property and suppress the activation of T-regulatory cells after infusion.

1. Sen et al. 2012. JAMA. Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

If you have further any queries related to stem cell supplement/therapy for Kidney Failure then contact us without any hesitation on our contact numbers:- +91-9650-988899/699988

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Treatment of Kidney Failure with stem cell supplements

Stem cell therapy is a biotherapy. It brings new hope for people with refractory and incurable diseases. In clinic, it has showed enormous curative effects in treating kidney disease.

Stem cell therapy is the infusion, or injection, of healthy stem cells into your body to replace damaged or diseased body cells. In treating kidney disease,stem cells can differentiate into new cells to replace the impaired renal intrinsic cells, thus reversing impaired kidney structure.

Stem cells are multifunctional cells with the ability of self-renewal and multi-directional differentiation.In certain condition,they can differentiate into various kinds of functioning cells.According to the developmental stage of stem cells,they can divide into embryonic stem cell and somatic stem cell.Based on the developmental potential of stem cells, they can divide into totipotent stem cell,pluripotent stem cell and unipotent stem cell.As they can generate all kinds of tissues and organs,they are called "universal cell".

In kidney disease,the kidneys are impaired significantly,thus resulting in high level of waste products and toxins in body. In such a bad environment,it is not possible for stem cells to differentiate and regenerate.Before stem cell therapy is performed,Blood Purification and Micro-Chinese Medicines Osmotherapy will be used to purify blood by removing all kinds of toxins and waste products from body.

Based on the homing ability,stem cells can differentiate into new cells to replace the impaired renal intrinsic cells.This can regenerate the impaired kidney tissues,thus restoring kidney structure.Thereby,the renal function will be improved.

1. It is widely used to treat diseases and conditions.

2. The best carrier of immunization and gene therapy.

3. Free of toxicity and immune rejection.

4. It can be used before patient understanding pathogenesis completely.

With stem cell therapy,the patients do not need have surgery. So there is no surgical risk in treating disease.As stem cells are primary cells with weak antigenicity on the surface, they will not cause rejection reaction after after being injected into body.

If you want to learn more about stem cell therapy, you can email to kidneycares@hotmail.com .

Stem cell therapy is an advanced technology with the characteristics of safety,non-toxity or low-toxity,and no side effect.The most common clinical adverse reaction is anaphlaxis, but which will recover in several hours by itself.Slightly high fever may occur and the patients do not need to worry about it.

I. Primary kidney disease such as Primary Nephrotic Syndrome, Acute Glomerulonephritis,Chronic Glomerulonephritis,IgA Nephropathy,MPGN,FSGS,and Membrane Proliferative Glomerulonephritis.

II. Renal injury caused by Autoimmune Diseases and connective tissue disease: Lupus Nephritis, Anaphylactic Purpura Nephritis, Glomerular Basement Membrane Disease, Primary Renal Vasculitis, Chronic Infectious Arthritis, Ankylosing Spondylitis, Psoriasis, Sicca Syndrome, Scleroderma, Polymyositis, Dermatomyositis, Behcet's Disease Etc.

III. Renal injury caused by Metabolic Diseases: Diabetic Nephropathy, Hyperuricemic Nephropaihy and hypokalemic nephropathy.

IV. Renal tubular disease and renal interstitial disease: Renal Tubular Acidosis, various kinds of acute and chronic interstitial nephritis;

V. Renal injury caused by infectious diseases: hepatitis B Virus associated glomerulonephritis, hepatitis C Virus associated glomerulonephritis

VI. cardiac function and IV

VII. Cardiorenal Syndrome and Hepatorenal Syndrome

VIII.Renal Injury caused by hypertension.

IX.Hereditary kidney diseases: Alport nephritis, thin glomerular basement membrane disease, Fabry disease etc.;

X. Polycystic Kidney Disease

I. Patient who is allergic to stem cell or patient with serious allergy;

II. pregnant women (woman in lactation period is allowed)

III. Infected patients who is still out of control;

IV. Serious mental illness patient, including patient with tristimania;

V. Severe Hypertension (BP is higher than 160/100mmHg)

VI. Patient with III and IV cardiac function, coronary disease, unstable angina, myocardial ischemia

VII. Patients with obvious renal atrophy

VIII. Patients with severe bleeding tendency

IX. Patients who are taking part in clinical research.

X. Polycystic Kidney Disease

Not all the patients are suitable to the stem cell therapy our hospital own strict selection system to ensure our curative effect.If you are interested in the therapy, you can consult with our online doctor now!

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Stem Cell Therapy - Kidney -cares

Stem Cell Therapy is one of the methods that have the potential to cure kidney diseases. As we know, the exact reasons of many kidney diseases are still unknown, let alone the cures for these diseases. Stem Cell Therapy is good news to many kidney disease patients. This article will give a brief introduction of this effective treatment.

In brief, Stem Cell Therapy is a kind of therapy that injects the stem cell into patients body to restore and rebuild the injured parts. Stem cell is basic cell of our body which can be found in umbilical cord or bone marrow and have the ability to mature into any type of tissue in our body. When the stem cells get into patients body, they will be attracted to the injured part. They differentiate into cells of the injured parts and replace the damaged cells. The purpose of treating disease can be reached. It is different from the traditional Chinese medicine and western medicine. The conventional way treat kidney disease is to suppress the overactive immunoreactions and reduce or alleviate inflammation and harmful substance to delay the progress of the disease. These treatments cant treat the disease completely.

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When these stem cells get into patients body, their kidneys will release cytokines to draw them to kidney. Then these stem calls will produce large quantity of daughter cells and these daughter cells will differentiate into all kinds of renal cells that are needed, such as renal tissues cells and renal blood vessel cells. If the microcirculation of kidney gets improved, the blood pressure of glomeruli will get lower. The relief of ischemia in kidney will contribute to the improvement of whole blood circulation. Simultaneously, the increase of EPO can alleviate the anemia condition of patients. Alone with enhancing of immunity, the excess immunoreactions will decrease, adjusting the immune system to work normally. The kidney lesion can be restored.

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This therapy can be widely used to treat many diseases and it can give patients complete treatments. Patients dont have to take many medicines or have an operation, so more and more kidney patients prefer to take this therapy for recovery.

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Since Stem Cell Therapy has the potential curative effects for kidney disease, many patients have asked whether it is available in India, Australia, USA, UK, Canada, etc. So far, Nephrologists in the hospital of China have applied the Stem Cell Therapy for years. They have rich experience in this therapy. If you are interested in this therapy, you can contact our online doctor. They will give you more detailed information.

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According to patients condition, the costs of Stem Cell Therapy are different. For example, some patients with little kidney function have to inject more stem cells than others, so their cost will be more. To learn the estimated total cost of Stem Cell Therapy for you, you can send your latest test report or illness description to kidney-symptoms@hotmail.com. Kidney experts here can tell you the treatment plan and cost in detail.

As for you own illness conditions, you can get some guidance related to diet, exercise, medicines or some natural remedies. The online consultation service is free. Please remember to leave your email address, or phone number so that we can contact you and help you! Please leave the patient's FULL name in case of a duplicate, and to make our doctor give timely response and help.

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Stem Cell Therapy Treats Kidney Disease or Kidney Failure ...

A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell. The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. Controversy about the exact definition remains and the concept is still evolving.[1]

The terms "progenitor cell" and "stem cell" are sometimes equated.[2]

Most progenitors are described as oligopotent. In this point of view, they may be compared to adult stem cells. But progenitors are said to be in a further stage of cell differentiation. They are in the center between stem cells and fully differentiated cells. The kind of potency they have depends on the type of their "parent" stem cell and also on their niche. Some progenitor cells were found during research, and were isolated. After their marker was found, it was proven that these progenitor could move through the body and migrate towards the tissue where they are needed.[citation needed] Many properties are shared by adult stem cells and progenitor cells.

Progenitor cells are found in adult organisms and they act as a repair system for the body. They replenish special cells, but also maintain the blood, skin and intestinal tissues. They can also be found in developing embryonic pancreatic tissue.

The majority of progenitor cells lie dormant or possess little activity in the tissue in which they reside. They exhibit slow growth and their main role is to replace cells lost by normal attrition. In case of tissue injury, damaged or dead cells, progenitor cells can be activated. Growth factors or cytokines are two substances that trigger the progenitors to mobilize toward the damaged tissue. At the same time, they start to differentiate into the target cells. Not all progenitors are mobile and are situated near the tissue of their target differentiation. When the cytokines, growth factors and other cell division enhancing stimulators take on the progenitors, a higher rate of cell division is introduced. It leads to the recovery of the tissue.

[3] The characterization or the defining principle of progenitor cells, in order to separate them from others, is based on the different cell markers rather than their morphological appearance.

Before embryonic day 40 (E40), progenitor cells generate other progenitor cells; after that period, progenitor cells produce only dissimilar mesenchymal stem cell daughters. The cells from a single progenitor cell form a proliferative unit that creates one cortical column; these columns contain a variety of neurons with different shapes.[citation needed]

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Progenitor cell - Wikipedia, the free encyclopedia

Chronic renal failure, also known as chronic kidney disorder (CKD), is a condition in which the kidney functioning declines slowly, but steadily. Chronic renal failure is a gradual process which goes on for weeks, months, or years, and the kidneys slowly stop working.

The main function of kidneys are to remove waste from the body and prevent toxins from building up in the bloodstream. They also produce hormones that control other body functions.

Causes:

The most common causes are diabetes (type 1 or type 2 diabetes) and high blood pressure. Damage to small blood vessels in the body is a complication arising from these two conditions. The kidneys blood vessels also get damaged, resulting into CKD.Other common causes are kidney infection, multiple cysts in the kidneys, urinary tract blockages, and excessive use of medications.

Symptoms:

Chronic renal failure symptoms appear years after it starts developing.This can be caught early only by conducting regular blood tests of a suspected patient. Some signs are more obvious than others. A few signs are abnormal urination, puffy eyes, hands, and feet (called edema), high blood pressure, fatigue and shortness of breath, loss of appetite. This can also go up to seizures and mental confusion.

Once a patient is diagnosed with chronic renal failure, the treatment depends on the medical problem and its complications that have caused the kidney failure.

Stem cells are known to have a tangible application in Chronic Kidney Disease (CKD). They have the ability to regenerate glomerulus, interstitium, blood vessels and tubules, the four essential components of the renal matrix and in-turn potentially reverses symptoms of CKD. They secrete protective and nourished factors that prevent progressive apoptosis of functional cells and stimulate replication of host cells.

The improvement can be depicted by a gradual decrease in BUN, creatinine, and uric acid levels. Overtime GFR and urine output should also improve substantially with regeneration of the kidney tissue.

Please furnish us with your detailed medical history, investigations and all relevant test reports to initiate the formal process of consultation with our doctors and ascertain eligibility for stem cell therapy. You can get in touch with is through our Contact Us page, or by calling our toll free number on 1800 222 454.

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Stem Cell Therapy for Chronic Kidney Disorder,Stem Cell ...

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Regenerative medicine for the kidney: stem cell prospects ...

Nowadays, there are millions of people living with kidney failure. To a large extent, kidney failure decreases patients life quality severely. Thereby, patients are eager to know is stem cells in China helpful to patients with kidney failur...Read More

IgA Nephropathy is caused by the deposition of IgA, without a timely and effective prevention and control, the kidney function will decline seriously. Traditionally, patients will be recommended with some hormones to remit their symptoms an...Read More

With the development medical science, the Treatment for Chronic Kidney Disease has been not so difficult and more and more patients take stem cell transplant therapy to reverse their kidney function. In beginning of the year of 2015, we hop...Read More

In the past, the only stage 5 kidney failure treatment is kidney transplant, but with the medical development, Stem Cell Therapy as the latest therapy has been used in treating kidney disease, now in India, USA, China, Stem Cell Therapy all...Read More

As the second advanced stage of kidney disease, there must be a certain fear in stage 4 kidney failure patients heart. An efficient treatment means the one which can reverse the condition and help patients live a normal life. The applicatio...Read More

Both Micro-Chinese Medicine Osmotherapy and Stem Cell Therapy are efficient treatments for kidney diseases. Their applications in treating kidney disease bring patients new hopes. Now follow us to learn more about Micro-Chinese Medicine Osm...Read More

Kidney failure patients have not been sentenced to death yet. Kidney failure itself will not cause death directly, but its severe complications can. Doctors will adopt the corresponding measures to deal with complications, however, to manag...Read More

End Stage Renal Failure is the last stage of chronic kidney disease, so it is the most severe stage. When condition develops End Stage Renal Failure, patients believe that dialysis or kidney transplant will be their only choice. However, is...Read More

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Stem Cells Transplant For Renal Failure-Kidney Failure

By Gordon Lore Stem cell research is one of the hottest, controversial, and ethical topics on the medical and political fronts. While research on adult stem cells (ASCs) is proceeding apace, studies on embryonic stem cells (ESCs), which many scientists believe will yield more positive and lasting results, has been stymied by ethical, political and religious concerns. Nonetheless, the eventual application of stem cell research to ongoing clinical application seems destined to be a major revolution in the history of medicine. What are stem cells? Let's start with the basics... Basic Building Blocks Cells comprise the body's basic building blocks. They are found in the skin, muscles, bones, and the internal organs and are important indicators as to how our bodies function. There are perhaps thousands of specialized cell types in the adult human body. Their purpose is to perform specific functions for the organs or tissues which they comprise. Those cells that have shown the greatest promise of replacing diseased organs with healthy new ones are stem cells. What Are Stem Cells? Stem cells are unspecialized entities that distinguish themselves from other body cells in two important ways: (1) Their numbers can be replenished for long periods of time by means of their division; and (2) Once they receive certain chemical signals, they can transform themselves into specialized units with specific functions such as a heart or nerve cell. Cell Types Stem cells can develop into different types, including:

Adult vs. Embryonic Stem Cells For some time, research scientists have been conducting studies to see if the stem cells found in the adult body have the same ability and promise for development as those in embryos. They discovered that ASCs appear to be less versatile while ESCs have far greater potential for treating and/or curing a wide variety of serious ailments. Why? Because they may develop into virtually every type of cell found in the body. ASCs, however, may be able to develop into only a limited number of cell types. ESCs can divide indefinitely when placed in a culture dish while this may not apply to ASCs, thereby reducing their capacity to form new types of cells. Scientists believe that studies of both ESCs and ASCs should continue since both "are critical to our understanding of the etilogy, progression, and treatment of disease." Embryonic Stem Cells ESCs are produced from four-to-five day-old embryos. At this stage, they are known as "blastocytes." Scientists create ESC cultures by transferring a blastocyte's cell mass into a culture dish. The cells are then removed and placed into fresh culture dishes. After being repeated many times, millions of ESCs are eventually produced. Blastotytes that are utilized for treating ESC lines are gotten from eggs that were fertilized in in vitro fertilization clinics but were never placed in a woman's uterus. The embryos that result were frozen and donated for research purposes. There are believed to be more than 400,000 unused frozen embryos in fertility clinics throughout the US. Adult Stem Cells ASCs are found in smaller numbers in most adult tissues. Their primary function is to maintain and repair their host tissues. One advantage of using a patient's own ASCs is that they can be expanded in culture dishes, then differentiated into the desired cells and reintroduced into the patient. Using the patient's cells would guarantee that they would not be rejected by the immune system. Compared to ESCs, however, there is a disadvantage in that it is harder to expand the numbers of ASCs in cell culture.2 In his research, a writer for the Los Angeles Times found that ASCs "do not bear the same ethical baggage as their embryonic counterparts because they can be harvested without creating or destroying new life. But scientists also believe they probably lack the wide-ranging curative potential that embryonic cells have."6 New Organs Most scientists seem convinced that the work done in stem cell research is so promising that it is only a matter of time before widespread therapy derived from this research is routinely used. This includes treating kidney disease and/or growing new organs for transplant. One major challenge revolves around tissue rejection. As in organ transplants, the immune cells in the body will attack transplanted cells as "foreign." This would trigger an immune rejection that could cause failure of the transplant and even endanger the life and welfare of the patient.1But pluripotent stem cells could well be a source of replacement cells and tissues to treat many diseases, including Parkinson's and Alzheimer's, spinal cord injuries, stroke, burns, diabetes, osteoarthritis, and rheumatoid arthritis. Widespread use of this therapy could also help ease the great shortage of organs available for transplantation.2 The National Kidney Foundation believes that "scientists studying stem cells may hold the key for the thousands of people currently on the list for donor organs and the 17 candidates who die daily waiting for hearts, lungs, kidneys, or livers that never come." Since stem cells have the ability to adapt and regenerate into different types of cells, they "have the potential to replace tissues damaged by disease. It is hoped that such tissue engineering might someday help doctors eliminate the need for many transplants and the anti-rejection drugs used in transplantation." Cloning new organs may be one way stem cells can benefit those waiting for donor organs. This involves "reprogramming a cell by replacing its nucleus with that of another cell so it becomes the generic equivalent of the original." Known as a nuclear transfer, the process "raises both hope as well as ethical concerns regarding the possibility of cloning humans for organs."3 Early-Stage Research As scientific investigation goes, stem cell therapy research is still in its infancy. Scientists have been able to do experiments with ESCs only since 1998. This is when James Thompson, MD, at the University of Wisconsin, used a technique he developed to both isolate and grow the cells. Real research was slow to continue, however, since federal funds to support limited ESC research have only been available from the time when President George W. Bush announced the decision to fund it in August 2001.2 The funding applies to research using only the 21 ESC lines existing at that time.9 Currently, because of the mandated limited research on ESCs, ASCs are the only kind of stem cells commonly used to treat human diseases. Actually, doctors have been transferring hematopoietic stem cells (HSCs) in bone marrow transplants for more than 40 years. In recent years, scientists have developed more advanced techniques of "harvesting" HSCs to treat leukemia, lymphoma, and several inherited blood disorders. Information on National Institutes of Health (NIH) clinical trials using stem cells can be found at:www.ClinicalTrials.gov.2 While waiting for the political and ethical firestorms to subside regarding the use of ESCs, research on ASCs continues. Treating Kidney Damage In 2001, scientists from the Imperial Cancer Research Fund and the Imperial College School of Medicine, London, England, "discovered that cells in bone marrow can be turned into tissue, which could help treat kidney damage caused by cancer or other diseases." They studied female kidneys transplanted into male patients with bone marrow transplants. They discovered that "the bone marrow cells had transformed into kidney tissue." "Doctors could use stem cells from the patient's own bone marrow to replenish cells lost by injury," stated Professor Nick Wright of Imperial Cancer's Histopathology Unit. "This would be of huge benefit as the kidney is very poor at repairing itself. There would be much less complication with the kidney rejecting the new cells because they would come from the patient's own body."5 Organ Size and Regenerative Capacity Harvard Stem Cell Institute Co-Director Doug Melton, MD, and his colleagues published a study in the journal Nature that "helps to explain the variation in organ regenerative capacity and in organ size determination as well. The findings also underscore the value of [ESCs] as tools to study normal development." This particular study involved the pancreas, but the thinking is that it could also eventually apply to the kidney. Melton and his colleagues discovered that "the ultimate size and regenerative capacity of... the pancreas is determined by the specific number of progenitor cells that are set aside during a very early time in development." That determines the size of the pancreas in the animal for the rest of its life and most likely holds true for humans as well. Melton believes his work is important because "it shows there are different kinds of mechanisms to control size, or tissue mass, for different organ systems." "This is another in a long list of examples where [ESCs] are extremely useful [in helping us] understand the basic facts about how tissues are made and maintained," Melton continued.4 Sidestepping "the Knotty Ethical Dilemmas" Scientists at the Whitehead Institute for Biomedical Research Cambridge, MA, "have created [ESCs] without using eggs or destroying embryos, an advance that may sidestep the knotty ethical dilemmas that have slowed stem cell research." The experiments on mice "returned mature cells... to a primordial, embryonic state... Those reprogrammed cells had the same properties as true [ESCs] such as the ability to turn into muscle, heart, nerve, and other tissue types." The researchers cautioned that their current research is "very far" from being turned into routine clinical medical treatments. Their findings were published in the journal Nature.7 Curing Renal Failure in Rats Researchers at the University of Tokyo claimed they succeeded in curing kidney failure in rats by transplanting somatic stem cells of the kidneys from healthy rats. "Somatic stem cells [SSCs]... can multiply and develop into a variety of other cells of that specific organ," the researchers stated in the June 20, 2007, issue of the Journal of Cell Biology. "Such cells cannot, however, transform into cells of other organs." Some scientists have said that human kidneys have similar SSCs. Therefore, the method can eventually be applied to cure renal failure in humans. In the experiment, the researchers transplanted 10,000 kidney somatic cells into the diseased kidney of the rats. "Blood tests conducted on the rats seven days later found that their kidney functions had returned to normal," the researchers explained. The Japanese scientists said they were ready "to study how to multiply [SSCs] extracted from human kidneys [in order to] develop a method for returning artificially multiplied cells back to the patients' kidneys."8 NIH Chief Calls For Lifting Restrictions Meanwhile, scientists, legislators, and others continue their effort to lift the restrictions on further ESC research. In a surprise move expected to mobilize opinion on Capitol Hill in March 2007, Elias A. Zerhouni, Director of the NIH, broke with the stance of the Bush administration by telling members of the US Senate Health Appropriations Subcommittee that he favored an end to restrictions on federal funding for ESC research. "It is clear today that American science... and the nation will be better served if we let our scientists have access to more stem cell lines," Zerhouni remarked. "We cannot... be second best in this area... It is important for us not to fight with one hand tied behind our back..., and NIH is the key to that."9 His comments are the strongest yet supporting the lifting of the President's 2001 ban restricting government funding to research using ESC lines.10 Stem Cell Protection Act Introduced In introducing the Human Cloning Ban and Stem Cell Protection Act of 2007, Senator Orrin Hatch (R-UT), also had something to say about stem cell research. "Many scientists believe that we are on the verge of a new revolution in medicine created by human stem cells," Hatch remarked. "The reason stem cells are important... is that many organs cannot make a sufficient number of new cells to replace damaged or lost ones... [An] example of how stem cells may treat common diseases is renal failure, which occurs in an estimated 40% of critical care patients. Dr. Christof Westenfelder, Professor of Medicine and Physiology at the University of Utah, has found that injecting stem cells into failing kidneys improves kidney function, prevents tissue injury, and accelerates regeneration."11 Congress Urges Lifting of ESC Research Ban On June 7, 2007, the US House of Representatives voted to send legislation that would remove the limits placed on ESC research to the White House for signing into law by President Bush. The House vote was 247 to 176. This vote, however, was 35 short of the two-thirds majority needed to override a Presidential veto.12 As he promised, on June 20, 2007, Bush used his powerful veto pen to knock the proposed legislation out of the political arena. This is the second consecutive year Bush has nixed such a bill. In announcing his veto, the President said he was encouraged from recent studies indicating it could be possible to grow stem cells from sources other than those derived from human embryos. "Researchers are now developing promising new techniques that offer the potential to produce pluripotent stem cells without having to destroy human life," Bush remarked. The President also issued an executive order to the NIH requesting that scientists conduct their research on stem cells that are "derived without creating a human embryo for research purposes or destroying, discarding, or subjecting to harm a human embryo or fetus." Critics, however, were quick to accuse Bush of using his Presidential powers to openly give the impression that he was supporting stem cell research when he was actually holding it back.14 Conclusion Christopher Thomas Scott, Director of the Stanford Program in Stem Cells and Society, said in his book that, by the year 2010, more than two million Americans are predicted to have end-stage renal disease at an aggregate cost of a whopping $1 trillion. Scott added that, despite the current future promise, developing new treatment therapies from stem cell research may take so long that "many diseases will have to wait for cures from other quarters of medicine." One reason cures from stem cell research may take so long has to do with the slow and very expensive method of discovering, testing, and manufacturing a new drug. It can take 10-15 years and cost nearly a billion dollars to have a new drug approved by the US Food and Drug Administration and brought to market.13 Despite the drawbacks, the many challenges, and the long time needed to bring their work to the patient's bedside, most scientists still believe that stem cell therapy will eventually revolutionize medical treatment. It's not a matter of if, but when.1 Author's Note: An important scientific breakthrough that has been hailed as "a landmark achievement" as well as "the biological equivalent of the Wright Brothers' first airplane"15 and the "Holy Grail"16 of stem cell research was widely reported just before Thanksgiving 2007. Even President Bush, who vetoed two bills that would provide federal funding for embryonic stem cell research, said he was "very pleased" by the breakthrough. Teams led by Shinya Yamanaka, MD, of Kyoto University in Japan and Junying Yu at the University of Wisconsin-Madison have reportedly created "the equivalent of embryonic stem cells from ordinary skin cells, a breakthrough that could someday produce new treatments for disease without the explosive moral questions of embryo cloning."15 Using stem cells could eventually "allow doctors to create stem cells with a specific patient's genetic code, eliminating the risk that the body would reject transplanted tissues or organs." A great advantage of the new technique involves its simplicity: "it takes just four genes to turn the skin cell back into a stem cell." This can be done in a standard biological laboratory. Also, skin cells can be much more easily harvested than embryonic cells. There are still problems with finding a safe way to transform the skin cells, but scientists are optimistic about solving this dilmma.16 The researchers indicated that "the rejuvenated cells were able to grow into all the main tissue types in the body," and "the discovery provides a clear road map for creating genetically matched replacement cells that could be used to treat patients for a variety of diseases."17 Also, the breakthrough will enable the Bush administration to "approve funding for a promising new line of research." Proponents of embryonic stem cell research, however, said that their approach was "too far along to abandon " and that "the two kinds of scientific research will probably move in tandem for some time."18 References 1. Stem Cell Research Foundation. Frequently Asked Questions. Website: http://www.stemcellresearchfoundation.org/AboutFAQ.htm. Accessed June 8, 2007. 2. Stem Cells and Diseases. In Stem Cell Information. National Institutes of Health, US Department of Health and Human Services. Website: stemcells.nih.gov/info/health.asp. Accessed April 24, 2007. 3. National Kidney Foundation. Do Stem Cells Hold the Key for the Future of Transplantation? Website: http://www.kidney.org/news/newsroom/printfact.cfm?id=44. Accessed April 12, 2007. 4. Colen, BD. Stem cell research sheds light on organ regeneration. Harvard University Gazette, February 22, 2007. Website: http://www.news.harvard.edu/gazette/2007/02.22/05-pancreas.html. Accessed March 13, 2007. 5. Goodenough, P. Adult Stem Cells May Help Treat Kidney Disease. CNSNews.com, July 25, 2001. Website: http://www.cnsnews.com. Accessed April 12, 2007. 6. Healy, M. Stem Cell Hope, Hype, Health. Los Angeles Times, March 5, 2007. 7. Naik, G. Stem-Cell Advance May Skirt Ethical Debate. Wall Street Journal, June 7, 2007. 8. Stem Cell News.com. Stem Cell Transplant Succeeds in Curing Kidney Failure in Rats. Mainichi Daily News, June 21, 2005. Website: http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm. Accessed June 7, 2007. 9. Alonso-Zaldivar, R, and Kaplan, K. Loosening of Stem Cell Limits Backed. Los Angeles Times, March 20, 1997. 10. Bridges, A. Bush's Own NIH Chief Opposes Stem Cell Ban. The Associated Press/abc News. Website: abcnews.go.com/Technology/print. Accessed April 12, 2007. 11. Carr, P. Hatch, Feinstein Promote Stem Cell Research, Human Cloning Ban. News Release from Orrin Hatch, United States Senator for Utah, March 8, 2007. Website: hatch.senate.gov. Accessed April 12, 2007. 12. Haveman, J. Stem cell bill passes House, but faces certain veto. Los Angeles Times, June 8, 2007. 13. Scott, CT. Stem Cell News: From the Experiment That Shook the World to the New Politics of Life. Pi Press. Website: http://www.npr.org/templates.story/story.php?storyId=5204335. Accessed April 12, 2007. 14. Reynolds, M. Bush vetoes embryonic stem cell funding. Los Angeles Times, June 21, 2007. 15. Ritter, M. Stem Cell Breakthrough Uses No Embryos. November 20, 2007. Website: news.aol.com/story/_a/stem-cell-breakthrough-uses-no-embryos/2007112016130990001. 16. AFP. Breakthrough opens door to organ transplants grown in lab. November 20, 2007. Website: afp.google.com/article/ALeqM5iLLQiJ8nHM4MYWfKhSC_g0_CkKeQ. 17. Kaplan, K. Stem cell milestone achieved. Los Angeles Times, November 21, 2007. 18. Alonso-Zaldivar, R. Science can't escape debate. Los Angeles Times, November 21, 2007. About the Author Gordon Lore was the Editorial Coordinator of KidneyTimes.com until 2007 andf ormerly was the Editor of several nephrology journals.

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Stem Cell Research and Kidney Disease - Renal Support Network

Renal stem cells are self-renewing, multipotent stem cells which are able to give rise to all the cell types of the kidney. It is involved in the homeostasis and repair of the kidney, and holds therapeutic potential for treatment of kidney failure.[1]

Strong evidence suggests that renal stem cells are located in the renal papilla.[2] Using stain-retaining assay (with bromodeoxyuridine, or BrdU), a low-cycling cell population was found in the papillary region, which was able to divide rapidly to repair the damaged caused by transcient renal ischemia.[2] These cells are able to incorporate into other renal tissues, and was able to repeatedly form spheres in 3D cultures, and clonal analysis also exhibited its multipotency.[2]

Other reports have suggested the renal tubule and renal capsule to be the site of stem cells. The renal capsule contain stain-retaining cells which exhibited markers for mesenchymal stem cells; after their removal, recovery was significantly slower post-ischemic injury. These evidence suggests a stem cell population exists within the renal capsule.[3]

Using in vivo lineage tracing techniques, Lgr5+ cells were found to contribute to the nephron, specifically to the ascending limb of the loop of Henle and the distal convoluted tubule. Thus, Lgr5+ cells can potentially be a marker for renal stem and/or progenitor cells.[4]

There is much debate regarding the cells involved in repair after injury; while some suggests that stem cells are the sole driving force of repair, others suggests that cells dedifferentiate after damage to act like stem cells.[5] Alternately, it was also reported that differentiated tubular epithelial cells are the driving mechanism for regeneration after injury, using proliferative expansion as the mechanism.[6]

Multipotent mouse kidney progenitor cells (MKPC) were obtained from Myh9 targeted mutant mice. Injection of MKPC into mice post-ischemic injury saw the MKPC regenerating different cell lineages and was able to regenerate renal function and enhanced survival.[7]

It has been reported that endogenous kidney tubular renal epithelial cells can be dedifferentiated into induced pluripotent stem cells by the treatment of only two factors - Oct4 and Sox2.[8]

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Renal stem cell - Wikipedia, the free encyclopedia

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1. What are Stem Cells?

Stem cells is a kind of self-renewing cells, which are immature and do not fully differentiate, and have the potential function of regenerating all kinds of tissues and organs. So they are called "universal cells".

According to the different original sources, stem cells can be divided into embryonic stem cells, somatic stem cells, hematopoietic stem cells, neural stem cells and muscle stem cells etc. According to the development potential, stem cells can be divided into totipotent stem cells, pluripotent stem cells and unipotent stem cells.

2. The Characteristics and Advantages of Stem Cells

a. Stem cells have the strong abilities of proliferation and multi-direction differentiation, so a lot of descendants are generated.

b. Through intercellular interactions and generating cell factors to inhibit the proliferation and immune reaction of T cells, thus rebuilding the immune function.

c. Stem cells are widely available, which are easy to separate, culture, proliferate and purify, daughter cells still remain the same characteristics as mother cells after proliferating many times.

d. Low immunogenicity. Stem cells dont have the character of immunological rejection and the problem of blood matching because stem cells are in the initial state and can not be identified easily.

e. Stem cells have the unique ability of homing. Through the function of homing, the traumatic signal can stimulate stem cells to differentiate new cells to replace the damaged organs and tissues so as to repair and rebuild the damaged cells.

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Stem Cells - Kidney Disease Treatment

With the development of modern medicine, Stem Cell Therapy or stem cell transplant has been used widely to treat various diseases including chronic kidney disease, especially kidney failure. If patients want to rebuild their kidney structure and reverse their kidney damage, this therapy may worth a try.

Stem cell is one class of cell with self-renewal and pluripotency ability. In center condition, stem cells can differentiate into various functioning cells, so they are applied in many medical fields including blood disease, respiratory system disease, cancer, nervous system disease, kidney disease, and so on.

In recent years, clinical research finds that stem cells can differentiate into inherent kidney cells and renal parenchymal cells, so stem cell transplant shows an obvious effect on repairing and rebuilding kidney functioning cells.

Compared with conventional therapies, stem cells wont cause rejection reaction, have strong differentiated ability, and dont cause any toxicity or side effect. Additionally, most kidney disease or kidney failure patients can use this therapy with doctors guidance.

Chronic kidney disease has always been one difficult problem in medicine. Stem Cell Therapy provides another new hope for these patients to obtain a brand new life. After taking this therapy, some remarkable improvements can be recognized easily. They are:

- High blood pressure, high creatinine level and high urea level decline obviously

- Capillary circulation all over the body improves

- Immune system is normalized

- Patients have more energy and stronger body

- Protein and red blood cells in urine reduce

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Stem Cell Therapy for Kidney Disease - Kidney Service China

Stem Cells in Focus is an ISSCR topic in which a series of webcasts is organized allowing the public to discuss Stem Cell topics with leaders in the field.

Yesterday STELLAR member Melissa Little dicussed her topic during a webcast session on:Exploring Organoids: Growing a Kidney in a Dish.

Below is an interview with Melissa conducted byMaya Chaddah leading up to the webcast.

There was great excitement in 2013 when Australian scientist, Prof. Melissa Little, at The University of Queenslands Institute for Molecular Bioscience in Brisbane, Australia saw tiny buds of tissue growing in a dish that looked like embryonic kidneys. Originally a cancer geneticist, she had spent years studying the genes and pathways that lead to the formation of Wilms tumor, a kidney cancer found in children. As the connections between abnormal kidney formation during development and kidney dysfunction in children became apparent, she began exploring new ways to help individuals with kidney disease.

In the 15 years since Prof. Little started focusing on kidney development, renal disease and repair, the rates of chronic kidney disease have skyrocketed globally, due in large part to conditions like diabetes, hypertension (high blood pressure), glomerulonephritis (immune-mediated disease) and cardiovascular disease. Although the adult kidney can repair some damage for example, after a night of excessive alcohol, a period of dehydration, rapid blood loss, or exposure to chronic toxins it cannot grow new nephrons, which are vital to its function, after we are born. So chronic kidney damage takes its toll and ultimately leaves individuals on dialysis or awaiting kidney transplants, which are in very short supply.

The kidney is a very complex organ, comprised of 250,000 to 2 million nephrons that filter the blood (about 5 cups/minute), resorb nutrients and excrete waste. Each nephron is shaped like the head of a wrench leading into a long convoluted tube that bends and winds. Blood is filtered at the head of the wrench and different points along the tube take back what the body needs ions, amino acids and water. The tube then dumps what the body doesnt want into a large pipe called the collecting duct, which funnels the waste to the bladder for excretion. Any condition that repeatedly affects the ability of the nephrons to filter the blood can lead to a build-up of kidney damage over time.

Prof. Littles team was keen to understand kidney development in humans. Because the adult human kidney cannot make new nephrons, they attempted to replicate the process by which nephrons develop in the human embryo, using cultured cells grown in the laboratory. This involved identifying the conditions under which embryonic stem cells derived from the earliest unspecialized cells in an embryo can be coaxed to make mesoderm, the layer of cells in the early embryo with the potential to make kidney cells. From there, they developed a very tight, quality controlled method for reproducibly making nephron progenitors, the cells which make nephrons, as well as early nephrons and collecting duct cells.

What Prof. Littles team finds amazing is how exactly these types of cells, the nephrons and their progenitors and collecting duct cells, self-assemble into three dimensional structures outside the body, in a totally artificial lab environment. She likens the mystery to when animals are born and immediately just know how to stand up and go to their mothers. The kidney organoids her team can grow right now are only tiny buds of tissue, much smaller than normal kidneys and less complicated, but clearly with the same kinds of cells found in an embryo making a kidney. The next steps are to keep pushing the kidney organoids down the developmental pathway that ends with fully functional organs, and then to investigate whether the nephrons could do their job if given a blood supply.

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STELLAR - Stem Cells in Kidney Disease - Stem Cell based ...

We can say that Stem Cell Therapy is the most efficient treatment for people with kidney disease. Its application makes dialysis or kidney transplant is no longer the only choice. No matter which type of kidney disease you are suffering from, you are still expected to live a normal life as the damaged kidneys can be saved. Now follow us to learn more about Stem Cell Therapy.

Stem Cells are pluripotent cells with strong power of self-replicating and directional differentiation. They are original and immature cells and have the potential ability to regenerate various tissues and organs.

There are different classifications of stem cells according to different criteria. They can be divided into totipotent stem cells, pluripotent stem cells and unipotent stem cells according to their developmental potentiality; according to the developmental stage, they can be divided into embryonic stem cells and somatic stem cells.

Certain stem cells and immune cells will be injected into body to activate human body's self-healing capability, regulate and control the diseased cells, activate cell function, increase the number of normal cells, enhance cell activity, improve the quality of cells and recover cell normal physiological functions.

Stem cells can differentiate into renal intrinsic cells, renal parenchymal cells which can replace the dead and necrotic renal cells and tissues and activate regeneration of body's own cells. These new functional cells can help repair kidney damages and rebuild kidney functions.

Stem Cell Therapy has not been commonly used in every country. Some argue that it is immoral to collect embryonic stem cells from the embryos because embryos is one form of life. Some people worry that companies will provide funds for in vitro fertilization and artificial abortion to obtain more cell lines and they suggest more researches on adult stem cells and give up embryonic stem cell research.

Nowadays, in China, mesenchymal stem cells or umbilical cord blood stem cells are used to replace embryonic stem cells.

-Stem cells have very strong power of proliferation and differentiation and they can produce large number of new functional cells.

-No rejection reaction. Because stem cells are the original cells of the body, the surface antigen is not obvious enough to be recognized by antibody. So there is no rejection reaction after a Stem Cell Therapy.

-It has the convenience of easy separation, culture, amplification and purification and still has the characteristics of stem cells after several times proliferations.

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Stem Cell Transplant For Kidney Disease-Kidney Failure

Abstract Introduction

Administration of mesenchymal stem cells (MSCs) has been shown to improve renal function in rodent models of chronic kidney disease (CKD), in part by reducing intrarenal inflammation and suppressing fibrosis. CKD in cats is characterized by tubulointerstitial inflammation and fibrosis, and thus treatment with MSCs might improve renal function and urinary markers of inflammation in this disease. Therefore, a series of pilot studies was conducted to assess the safety and efficacy of intravenous administration of allogeneic adipose-derived MSCs (aMSCs) in cats with naturally occurring CKD.

Cats enrolled in these studies received an intravenous infusion of allogeneic aMSCs every 2 weeks collected from healthy, young, specific pathogen-free cats. Cats in pilot study 1 (six cats) received 2 106 cryopreserved aMSCs per infusion, cats in pilot study 2 (five cats) received 4 106 cryopreserved aMSCs per infusion, and cats in pilot study 3 (five cats) received 4 106 aMSCs cultured from cryopreserved adipose. Serum biochemistry, complete blood count, urinalysis, urine protein, glomerular filtration rate, and urinary cytokine concentrations were monitored during the treatment period. Changes in clinical parameters were compared statistically by means of repeated measures analysis of variance (ANOVA) followed by Bonferronis correction.

Cats in pilot study 1 had few adverse effects from the aMSC infusions and there was a statistically significant decrease in serum creatinine concentrations during the study period, however the degree of decrease seems unlikely to be clinically relevant. Adverse effects of the aMSC infusion in cats in pilot study 2 included vomiting (2/5 cats) during infusion and increased respiratory rate and effort (4/5 cats). Cats in pilot study 3 did not experience any adverse side effects. Serum creatinine concentrations and glomerular filtration rates did not change significantly in cats in pilot studies 2 and 3.

Administration of cryopreserved aMSCs was associated with significant adverse effects and no discernible clinically relevant improvement in renal functional parameters. Administration of aMSCs cultured from cryopreserved adipose was not associated with adverse effects, but was also not associated with improvement in renal functional parameters.

Chronic kidney disease (CKD) is a common condition in elderly cats and is characterized by tubulointerstitial inflammation, tubular atrophy and interstitial fibrosis with subsequent progressive loss of renal function [1,2]. Currently there is no definitive therapy short of renal transplant to improve kidney function in cats with CKD. Therefore, novel and effective therapeutic options are highly desired for treating this disease in cats.

Recently, a number of studies have suggested the use of mesenchymal stem cells (MSCs) as a novel treatment option for management of CKD, based on encouraging data from rodent studies [3-7]. There have been several rationales advanced for the use of MSCs for treatment of CKD. Rodent studies have suggested that MSCs may incorporate into the renal parenchyma and give rise to new renal tubular cells, though the process appears to be relatively inefficient [8-17]. MSCs also exert potent anti-inflammatory and antifibrotic effects and may therefore indirectly improve renal function by reducing disease-associated inflammation and fibrosis through paracrine effects [3-7]. For example, MSCs have been shown to inhibit lymphocyte proliferation and cytokine production, suppress dendritic cell function, and suppress interferon (IFN) production by natural killer (NK) cells [18].

Since inflammation appears to be present at all stages of CKD in cats, the immunomodulatory actions of MSCs are appealing as an alternative means of suppressing intrarenal inflammation long term and with fewer side effects than with conventional anti-inflammatory drugs. In the majority of experimentally-induced CKD models investigated, MSC administration resulted in improved renal function, decreased intrarenal inflammation, and reduction of renal fibrosis [3-7]. Thus, MSC therapy may be an effective new approach to slow the progression of CKD and improve renal function.

Previous studies have demonstrated that cultured MSCs can be administered intravenously to rodents as well as to humans. However, in rodent models there is a significant risk of pulmonary thrombosis when high numbers of MSCs are rapidly administered intravenously [19]. Alternative routes of delivery have included injection via the renal artery, injection directly into the renal parenchyma, and injection into the renal subcapsular space [3-7]. One potential advantage of intravenous delivery compared to other routes may be the induction of renotropic paracrine effects following intravenous administration of MSCs [20].

Based on compelling results from rodent studies, we conducted a series of pilot studies to investigate the safety and potential efficacy of adipose-derived MSC (aMSC) therapy as a treatment for cats with naturally occurring CKD. These studies were designed to test the hypothesis that allogeneic cryopreserved aMSCs could be safely administered to cats with CKD and would result in improvement in kidney function. For this study, aMSCs were derived from allogeneic, healthy, specific pathogen-free (SPF) donor cats and cryopreserved, either as cells or adipose tissue, prior to intravenous administration to study cats. One primary study endpoint was to determine safety and potential adverse effects of repeated intravenous administration of cryopreserved aMSCs. The second major endpoint was to determine whether repeated MSC administrations were associated with improvement in renal function or urinary markers of intrarenal inflammation. These studies produced evidence of modest, but unlikely to be clinically significant, improvement in renal function but also showed evidence of significant adverse effects associated with intravenous administration of higher doses of cryopreserved aMSCs.

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Stem Cell Research & Therapy | Full text | Safety and ...

Renal failure is a common death risks in India. Stem Cell Therapy in China can be some of help for India patients to reserve renal failure A prospective study of all new cases of chronic renal failure (CRF) including inservice referrals was done at our hospital over a period of 1 year from May 1994 to April 1995. The diagnosis of CRF was based on clinical, laboratory, and radiological features. Kidney biopsies were done when indicated. The patients were subdivided into various etiologic groups of primary renal disease according to standard criteria. However, it carries a poorer prognosis due to late referral and limited availability and affordability of renal replacement therapy in India. Then what is the best way to solve this problem in India? Stem Cell Therapy can help you. The characters of Stem Cell Therapy in Shijiazhuang kidney disease hospital are as follows:Stem Cell Therapy Treats Kidney Disease 1. Obvious treatment effects. Since the powerful ability of self-renewing and multiple differentiations, Stem Cell Therapy can treat diseases completely, repairing the damaged cells and recovering the normal cells. Therefore, it can prevent the relapse of disease.Stem Cell Therapy for CKD Stage 5 Patients 2. No rejection reaction. Because Stem Cell Therapy are the original cells of the body, the surface antigen is not obvious and is not easy to be recognized by antibody. Therefore, patients needn't take immune-suppression drugs.How Can Stem Cell Therapy Stop Expanding Kidney 3. No pain. Stem Cell Therapy is different from kidney transplant and heart transplant. Stem Cell Therapy are just injected by vein without surgery. 4. No side effects. Stem Cell Therapy is a kind of safe treatment. This treatment is non-toxic and has no side effects.Can Stem Cell Therapy Cure FSGS 5. Adequate source of Stem Cell Therapy. There are amounts of Stem Cell Therapy in the body. Stem Cell Therapy are easy to separate, cultivate and purify.

As a latest advanced treatment for kidney disease, Stem Cell Therapy have helped many patients with kidney disease, its good effects gained many flowers and applause. If you want to know more information about Stem Cell Therapy, please chat with experts on line.

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treatment for kidney disease: Stem Cell Therapy for renal ...

Sir, I am IgA Nephropathy patient, my creatinine level 6.1 and hemoglobin is 8.8, what should I do? we get the question on our website. In order to help more patients, the kidney experts from Shijiazhuang Kidney Disease Hospital of China gi IgA Nephropathy is one of a group of conditions called glomerulonephritis, which caused by deposition of a protein (immunoglobulin A). Along with the development of illness condition, patients are prone to suffer from symptoms. Why does the High Creatinine Level is usually taken as an indicator to tell that you have kidney damage. However, some patients wonder that whether kidney infection can raise your creatinine level or not. To know the answer, please read on. For the ques Kidney Failure is a condition that can not only affect your normal life but also can shorten life time. Facing the threatening disease, aside from taking necessary treatments, it is also necessary to have a balanced and healthy diet plan. D Stage 3 Kidney Failure is one of critical periods to take necessary treatments so as to stop progression of illness condition and protect kidney from the further damage. Well then, what steps can I take to prevent serious matter? Actually, IgA Nephropathy is a kind of glomerulonephritis which caused by autoimmune disorders. Many patients with the kidney damage must have the concern: what is the life expectancy for IgA nephropathy patients? Here we will share some information Chronic Kidney Disease or Kidney Failure patients may be prescribed some pain killers which are commonly used for relieving pain feeling. However, some patients may have the concern: can pain killers cause high creatinine level? Actually, c Cottage cheese is a good source of protein, calcium, potassium, phosphorus, sodium, vitamins and so on, which play a significant role in keeping peoples health. Can I eat cottage cheese with Stage 4 CKD? patients have to consider the pros a Kidney disease is really not a joke because patients will suffer from more and more related symptoms and complications due to poor renal function. Well then, is there any ways can increase renal function naturally? Actually, different stage What food should I take to improve anemia caused by CKD? I am sure that question is one of concerned questions who are suffering the condition. Please dont worry. Here we will give your some suggestions.And you can choose freely according t Herb is one of important parts in Traditional Chinese Medicine which has been more and more popular in the modern medical area. And some herbs also have shown a good efficacy on relieving symptoms of Polycystic Kidney Disease, like back pai My son stared dialysis a week ago, is he a good candidate for a stem cell therapy? Creatinine 3.7 is much higher than the normal range which means that much toxins and wastes have deposited in the body. Sometimes, it suggests that you have progressed to Stage 3 Kidney Disease with moderate kidney damage. Well then, is it n I have kidney cyst and I want to try osmotherapy, how can I use? Please help me. Leg and foot swelling also known as leg and foot anemia, is the most common symptom for patients with kidney damage. When it occurs in Stage 4 CKD, do you know the reasons? Do you know the effective treatments? Now, follow me and find out t Kidney cyst refers that fluid-filled sac forming on kidneys. Small kidney cysts have no affect on the body, but large cysts will trigger a myriad of problems. A person with 5cm cyst on right kidney may suffer pain, blood in urine, infection Cysts on both kidneys is very common a disease that is more commonly seen in elderly people. Usually, when cysts are small in size, they cannot cause symptoms, while when cysts enlarge to a certain, they will trigger different symptoms. Som Pain is the common symptom for patients with kidney cysts, especially when cysts enlarge to a certain size. Compared to western pain killers, some herbal medicines have shown more safe, natural and effective effect on relieving related symp BUN (Blood Urea Nitrogen) is an indicator to reflect how well your kidneys are working, which is the metabolic products of protein. Normally, it is formed in liver and discharged out by the kidneys. Well then, should I be concerned a BUN le Symptoms of Lupus Nephritis can vary widely from person to person, including swelling, back pain, blood in urine, high blood pressure, etc. Some patients are more likely to feel fatigue. How does lupus nephritis cause fatigue? And how to de Stem Cell Therapy is also known as stem cell transplant which has tremendous promise to help us understand and treat a range of diseases including chronic kidney disease, especially Kidney Failure. Well then, how does the treatment help ren Kidney cyst is a common kidney disease which are more commonly seen in elderly people. they are fluid-filled sacs that either simple kidney cyst or complex renal cyst. Actually, when they are small, normally they wont induce symptoms, but w I have a questions about my kidney cysts: what should be done for reducing kidney cyst? Please advice me. My 4-year old daughter has HSP and now has 1+protein in her urine. We are going to recheck in 2 days, but now I am worried about protecting her kidneys. The words come from a father. In order to give his professional help, we consult t

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Stem Cell Therapy: New Hope for Kidney Failure ...

Home > Understanding Kidney Disease > Kidney Diseases > Kidney Failure > Kidney Failure Treatment > 2015-06-08 15:16| Font Size A A A

Stem Cell Therapy is also known as stem cell transplant which has tremendous promise to help us understand and treat a range of diseases including chronic kidney disease, especially Kidney Failure. Well then, how does the treatment help renal failure patients? Now, lets see.

Kidney Failure is a medical condition in which the kidneys fail to adequately filter waste products from the body. Along with the progression of illness condition, patients will experience more and more symptoms, and patients will also lose more and more functioning renal cells and tissues. Eventually, Dialysis or Kidney Transplant will be the last choice for patients. But I am sure that the consequence is not what we want. Because patients may suffer from more and more symptoms. As the matter of fact, although kidney failure cannot be cured completely, we still can do useful something so as to stop or at least slow down the progression of illness condition totally.

What is the stem cell therapy?

Fortunately, Stem Cell Therapy can be new hope for kidney failure patients. Briefly, stem cells are characterized by their capacity for self-renewal and ability to differentiate into specialized cell types.

How does it help kidney failure patients?

In recent years, clinical research finds that stem cells can differentiate into inherent kidney cells and renal parenchymal cells, replacing the damaged or necrotic kidney cells and tissues. So stem cell transplant shows an obvious effect on repairing and rebuilding kidney functioning cells. In the condition, the poor renal function can get improvement and kidney will also function normally. Last, patients will also get rid of dialysis and live a improved-quality life.

Is there any risk to take the therapy?

Compared with conventional therapies, stem cells wont cause rejection reaction, have strong differentiated ability, and dont cause any toxicity or side effect. Whats more, after many years research and practices, the success rate of Stem Cell Therapy has been improved largely. Now, it has risen to 90% especially in the specialized kidney disease hospital. I believe most kidney disease patients can get confidence from this success rate.

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Stem Cell Therapy: New Hope for Kidney Failure Patients

Chronic kidney disease(CKD), also known as chronic renal disease, is a progressive loss in renal function over a period of months or years. The symptoms of worsening kidney function are unspecific, and might include feeling generally unwell and experiencing a reduced appetite. Often, chronic kidney disease is diagnosed as a result of screening of people known to be at risk of kidney problems, such as those with high blood pressure or diabetes and those with a blood relative with chronic kidney disease. Chronic kidney disease may also be identified when it leads to one of its recognized complications, such as cardiovascular disease, anemia or pericarditis.

Chronic kidney disease is identified by a blood test for creatinine. Higher levels of creatinine indicate a falling glomerular filtration rate and as a result a decreased capability of the kidneys to excrete waste products. Creatinine levels may be normal in the early stages of CKD, and the condition is discovered if urinalysis (testing of a urine sample) shows that the kidney is allowing the loss of protein or red blood cells into the urine.

To fully investigate the underlying cause of kidney damage, various forms of medical imaging, blood tests and often renal biopsy (removing a small sample of kidney tissue) are employed to find out if there is a reversible cause for the kidney malfunction.

Recent professional guidelines classify the severity of chronic kidney disease in five stages, with stage 1 being the mildest and usually causing few symptoms and stage 5 being a severe illness with poor life expectancy if untreated. Stage 5 CKD is also called established chronic kidney disease and is synonymous with the now outdated terms end-stage renal disease (ESRD), chronic kidney failure (CKF) or chronic renal failure (CRF).

There was no specific treatment unequivocally shown to slow the worsening of chronic kidney disease, until recently. If there is an underlying cause to CKD, such as vasculitis, this may be treated directly with treatments aimed to slow the damage. In more advanced stages, treatments may be required for anemia and bone disease. Severe CKD requires one of the forms of renal replacement therapy; this may be a form of dialysis, but ideally constitutes a kidney transplant or potentially stem cell therapy.

CKD is initially without specific symptoms and can only be detected as an increase in serum creatinine or protein in the urine. As the kidney function decreases:

People with chronic kidney disease suffer from accelerated atherosclerosis and are more likely to develop cardiovascular disease than the general population.

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Stem Cell Kidney Diseases - World Stem Cells, LLC

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Stem Cell Therapy - CKD Treatment

The primary function of the kidney is to remove excess water and waste from the body. Acute kidney failure occurs when the kidneys are suddenly unable to remove waste and concentrate urine without the loss of electrolytes. Chronic kidney failure is the gradual loss of kidney function over time.

The causes of kidney damage can include acute tubular necrosis, a kidney disorder, autoimmune kidney diseases, extremely low blood pressure, clotting disorders of the blood vessels in the kidneys, certain infections that affect the kidney including septicemia, pregnancy complications and urinary tract obstruction.

There are many possible kidney failure symptoms: bloody stools, bruising easily, bad breath, mood changes, reduced appetite, fatigue, hand tremors, decreased sensation, flank pain, high blood pressure, nosebleeds, nausea, vomiting, metallic taste in the mouth, seizures, fluid retention, bleeding longer than usual, persistent hiccups and urination changes.

Adult stem cells are undifferentiated and can morph into the cells of countless tissues, organs and structures within our bodies. Used in many treatments, they restore damaged fibers and rejuvenate impaired cells through cell division, a process in which they multiply indefinitely. Stem cell science has seen much progress in recent years with many new discoveries being made.

Angeles Healths Stem Cell Therapy program can be applied to a variety of conditions including kidney failure. Like many other procedures treatment for kidney failure uses autologous adult stem cells. These are harnessed from the kidney failure patient themselves so there is very little chance of a patients body rejecting them.

Stem cells are taken from the patients bone marrow and adipose tissue, or fat. Adipose tissue extraction tends to be more worthwhile than bone marrow extraction, due to the tissue producing up to ten times more stem cells. It is therefore much more widely used. It is also a much easier process to carry out.

The therapeutic endovascular placement of adipose-derived stem cells that makes up the Stem Cell Therapy treatment program at Hospital Angeles enables organs and structures to be targeted directly.

The specialized non-invasive catheterization process is manageable for the patient. Stem cells can be easily distributed around the body, there is no need for an anesthetic and the procedure is over in less than an hour.

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Treatment for Kidney failure with Stem Cell Therapy | Stem ...