StemCell Therapy

Regenexxprovides various regenerative medicine options that facilitate healing, without surgical intervention. Dr. Henry Stiene (non-spine) and Dr. John Brannan (treatment of the spine) are the exclusive providers ofRegenexxtreatments in the Tri-State Area.

Beacon Orthopaedics currently has seven physicians that provide regenerative medicine for patients. These are non-invasive or minimally invasive options that can help patients heal faster without surgery. A popular regenerative medicine option is PRP (platelet rich plasma) therapy. PRP Therapy utilizes a patients own blood to rebuild and heal a damaged tendon or cartilage in the body. This type of regenerative therapy can help relieve pain in the affected area and also jump starts the healing process.PRP is most commonly used to treat patients with osteoarthritis in the hip, knee or shoulder. Patients seeking regenerative medicine for chronic tendonitis in the ankle or elbow often choose PRP treatments as well. More conservative methods of treatment are typically attempted first, such as rest, medication, physical therapy, etc., but when those methods fail, PRP is often a good solution.

Stem cells therapy is increasing in popularity. As with other forms of regenerative medicine, stem cell treatments can fix joint, tendon, or other pains without surgery.Stem cells are basic human cells that have the capability of creating new cells in the body. When applied to regenerative medicine, this means they can be used to create new healthy bone, tissue, etc. Stem cell procedures are now being used in orthopedics, often to treat bone fractures, healing ligaments or tendons, regenerating articular cartilage in arthritic joints, and replacing degenerative vertebral disks.

Prolotherapy (short for proliferant therapy) is a regenerative treatment used to treat pain arising from joints, tendons, ligaments, muscles, and the connective tissue that holds these structures together. Pain from these structures may be due to injury, overuse, normal wear and tear (degeneration) and nerve injury or irritation.

Prolotherapy uses solutions such as concentrated dextrose that produce a minor injury or inflammation to these structures. Connective tissue such as ligaments and tendon have a very poor blood supply and this severely limits the ability of these tissues to heal themselves as living tissue needs a healthy blood supply to maintain nourishment and repair itself.

Perineural InjectionTherapy (PIT) is a proven safe, effective treatment for patients who may not be goodcandidates for joint replacement surgery or biologic options such as stem cell injections or PRP. Perineural injections are used for treating inflamed and injured nerves causing chronic pain. This pain is often due to trauma, arthritis, sports, overuse, occupational, and surgical injuries. For additional information, please click here.

*Dr. Henry Stiene and Dr. John Brannan are the exclusiveRegenexx providers in the Greater Cincinnati Area. To schedule a consultation with either physician, please call (513) 354-3700.

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Regenerative Medicine - Beacon Orthopaedics & Sports Medicine

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT).

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues. The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it. The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury. Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery. Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:

Prolotherapy:

This treatment involves injecting a proliferant (usually dextrose) into weakened or injured joints, ligaments, or tendons. With a precise injection of a mild irritant solution directly on the site of injury, prolotherapy creates a mild, controlled inflammation that stimulates the bodys natural healing mechanism to lay down new tissue on the weakened area. Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain. Injection sessions are done 3-6 weeks apart, and usually a series of 3 injection sessions is done and then the response is assessed. The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves. They can be used for any part of the body where nerve pain exists. After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.

Platelet Rich Plasma Therapy (PRP):

During PRP therapy, a small vial of your own blood is drawn and placed in a centrifuge to separate the platelet-rich plasma from other blood components. This highly concentrated platelet-rich layer contains growth factors and a variety of cells. Growth factors stimulate local cells for tissue repair and remodeling. Your PRP is injected into and around the area of injury. Several injections may be done at the injured site at one time to fully treat the area. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Cell Therapy:

Stem cells(MSCs) are readily available and can be harvested from your bone marrow through a needle. Once injected into an area of injury, MSCs secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle. MSCs can be thought of as the manager of your bodys innate healing potential. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Lipoaspirate (Fat) Graft:

Lipo aspirate therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic. It is especially effective for areas where there are soft tissue defects such as tears or arthritis. This type of injection is used in collaboration with PRP or bone marrow aspirate cell injections, which deliver growth factors to the injured area.

Alpha 2 Macroglobulin (A2M):

A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown and progression of arthritis. A small vial of your own blood is drawn and placed in a centrifuge to separate the blood components, then is injected. A2M attaches to and removes the destructive enzymes that damage cartilage cells in the joint. The A2M is soothing to the joint and acts like a natural anti-inflammatory.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment. The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.

What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background. Rene S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function. With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine. Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.

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Syracuse Regenerative Medicine - rsmmd.com

Genesis Pain and Regenerative Medicine is a leader in the treatment of pain. Dr. Enty is a pain doctor offering in officeand outpatient treatments for neck and back pain, failed back surgery, headaches, arthritis, neuropathy, diseases, joint injuries, soft-tissue injuries and sports related injuries. Genesis pain doctor offers PRP Platelet Rich Plasma and HTA Human Tissue Allograft procedures. Our goal is to maximize patients quality of life and minimize pain associated with specific conditions through non-surgical options.

Persistent pain affects millions of Americans daily and costs individuals and businesses billions of dollars annually from direct medical expenses and lost productivity. Genesis Pain and Regenerative Medicine offer traditional pain management treatments as well as advanced medicine options through regenerative medicine. Our physicians provide a comprehensive approach to the treatment of pain which has proven to achieve the best results. Our approach, which includes working with a team of specialists, takes into consideration not only our patients pain but also any other physical, emotional, psychological or lifestyle difficulties.

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Don Enty, MD | Genesis Pain and Regenerative Medicine Dr. Don ...

Regenerative medicine is a specialized, innovative new wave of treatment that cane be done to change the game for acute and chronic foot and ankle pain. These treatments are used to promote complete healing and regeneration rather than just treating your symptoms.

Our highly-trained team of Tampa podiatrists uses the latest technology using evidence-based medicine to treat problems conservatively that were once only solved by surgery.

Here at Bayshore Podiatry, we specialize in the following regenerative medicine procedures to help heal your foot and ankle pain:

Platelet Rich Plasma (PRP) is a form of regenerative medicine that promotes soft tissue and bone healing and stimulates recovery. When introduced into torn tendons or ligaments, they stimulate healing. With arthritis, they decrease inflammation and reverse the degradation process.

*Learn more about Platelet Rich Plasma*

Stem cell therapy is an amazing new medical technology that uses the healing power of ones own body (or a matching donor) to repair certain foot and ankle conditions. This treatment promotes bone and soft tissue healing to help remove scar tissue, reduce inflammation, and help promote new tissue growth faster!

Learn more about Stem Cell Therapy

Dr Zachery Barnett is a recommended physician/provider through Amniox in the Tampa region specializing is clarixflo, injectable amnion for tendon, joint, musculoskeletal and nerve pathology. Schedule an appointment today or call us at (813) 877-6636 to learn more about our regenerative medicine treatments and if theyre the right fit for you!

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Regenerative Medicine - Bayshore Podiatry

IU School of Medicine 8/15/18

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Indiana University School of Medicine is investing more than $20 million over the next five years to establish a new center focused on regenerative medicine, a rapidly developing field aimed at repairing and replacing tissue and organs damaged by age, disease or trauma.

Chandan Sen, PhD, one of the nations leading experts in the discipline, has been recruited from The Ohio State University to serve as inaugural director of the Indiana Center for Regenerative Medicine and Engineering effective August 15. He brings with him more than $10 million in research grants and a team of more than 30 scientists and staff who will study how to tap into the power of regenerative medicine and engineering to heal burns, develop new therapies for diabetic complications, treat injured soldiers, and even regrow damaged and diseased tissue.

The potential of regenerative medicine is tremendous, and in Chandan Sen we will have one the countrys most accomplished and innovative researchers leading our program, said IU School of Medicine Dean Jay L. Hess, MD, PhD, MHSA. We expect IU School of Medicine to be among a handful of top institutions delivering on the promise of regenerative medicine. The discoveries made and the new therapies and devices developed at this center will improve the lives of Hoosiers and of patients everywhere.

Sen and his team have already developed a non-invasive, nanochip device that uses technology called tissue nanotransfection to reprogram one type of tissue into another with a simple touch and electric spark that is harmless to the body. In laboratory studies, the group was able to convert skin tissue in mice into functional blood vessels that were used to repair a badly injured leg. Similar experiments have shown promise in larger animals such as the pig.

The technology has been licensed with the goal of making it available for use in humans. Sen feels confident that this technologywhich avoids the use of stem cells and is simple to usewill one day enable skin and other tissue to be converted to tissue types necessary for therapy. For example, it may help prevent amputation in diabetics and repair nerve damage related to neuropathy.

A team of interdisciplinary experts will continue developing the technology at the Indiana Center for Regenerative Medicine and Engineering, which will involve a collaboration with faculty across multiple disciplines at Indiana University as well as in the Purdue University Weldon School of Biomedical Engineering.

The vision of this center is to take regenerative medicine forward in a way that no one else is doing in the world today, Sen said. Each cell of the adult body has some regenerative properties, some more than others. Our approach aims at reprogramming adult tissue utilizing our own technologies that can be readily used in a field setting without any laboratory-based procedures. We plan to use the technologies at our disposalsome of which were generated by our group and some of which are available at IU and Purdueto develop transformative health care solutions that will clearly impact peoples lives.

PARTNERSHIPS IMPROVE PATIENT HEALTH AND ECONOMIC VITALITY

The Indiana Center for Regenerative Medicine and Engineering will be located in 11,000 square feet of newly renovated space in the Medical Research & Library building on the IU School of Medicine campus in downtown Indianapolis.

The center will be closely linked to the clinical program at Indiana University Health, with Sen serving as executive director of the IU Health Comprehensive Wound Center. Sens science has led to FDA-cleared commercial products in the domain of wound care.

Beyond the potential benefits for patient care, the Indiana Center for Regenerative Medicine and Engineering also promises to contribute to Indianas critically important life sciences, tech and advanced engineering economy.

Sen will collaborate with industry partners, including Indianapolis-based Cook Regentec and West Lafayette-based Cook Biotech, as part of the INCITE program. INCITE, funded with a $25 million grant from the Lilly Endowment Inc., is designed to attract top scientists to Indiana whose expertise are in alignment with Indianas major life science companies. A portion of Sens start-up package is being funded through the grant.

The regenerative medicine center will also place a heavy emphasis on commercialization, ensuring that discoveries are developed into marketable solutions that reach patients. With that in mind, Sen and the center will have space in the new 16 Tech innovation community planned for the near west side of Indianapolis.

As a research-intensive medical school, we are highly focused on developing new therapies for patients, said Anantha Shekhar, MD, PhD, executive associate dean for research affairs. To be successful, we must continue building productive relationships with industry and ensure we develop pathways for our research to be translated into new drugs, diagnostics and devices. Chandan has demonstrated that he is adept at turning ideas into innovative solutions and will no doubt contribute to Indianas standing as a leader in the life sciences.

Sen will also hold a leadership role in the IU Precision Health Initiative. The first of Indiana Universitys Grand Challenges, the IU Precision Health Initiative aims to prevent and cure diseases through a more precise understanding of the genetic, behavioral and environmental factors that influence a persons health. With the establishment of the Indiana Center for Regenerative Medicine and Engineering comes the creation of a sixth pillaror scientific area of focusof the IU Precision Health Initiative focused on regenerative medicine and engineering.

STATEMENTS FROM COLLABORATORS AND INFLUENCERS

IU Health looks forward to working closely with the new center and its scientists to help apply their research to improvements in patient care. The advances coming in regenerative medicine stand to benefit patients at IU Health and elsewhere. Dennis Murphy, President and CEO of IU Health

Dr. Sens innovative work shows the real-world impact of university-based research. His visionary innovations promise to save and improve lives not just across the Hoosier state, but around the world. Fred H. Cate, Vice President for Research, Indiana University

Cook is happy to welcome Dr. Sen to the growing life science ecosystem here in Indiana. We share with Dr. Sen a deep interest and commitment to helping patients in areas like regenerative medicine, tissue engineering and wound care. The presence of research and innovation teams at Cook Regentec in the 16 Tech innovation district adjacent to IUSM and also at Cook Biotech in West Lafayette provides a tangible opportunity for collaboration and technology advancement. Rob Lyles, President, Cook Regentec

16 Tech is purposefully designed to stimulate innovation and provide opportunities for entrepreneurs, innovators, researchers and ideas to collide. Its also a place that will attract world-class talent. We are pleased to welcome the Indiana Center for Regenerative Medicine and Engineering to 16 Tech and to provide the environment where collaboration among world-class talent could very well lead to life-changing medical advances. Bob Coy, President and CEO of 16 Tech Community Corporation

This exciting and timely initiative will bolster Indianas position as a life science leader through the development of innovative technologies that enlarge health care approaches and open new business opportunities. George R. Wodicka, Dane A. Miller Head and Professor of Biomedical Engineering, Purdue University Weldon School of Biomedical Engineering

ABOUT CHANDAN SEN, PHD

Originally from India, Chandan Sen graduated from the University of Calcutta with a bachelors and masters degree in physiology and earned his PhD, also in physiology, from the University of Eastern Finland. He trained as a postdoctoral fellow at the University of California at Berkeley in the Department of Molecular and Cell Biology.

Sens first faculty appointment was in the Lawrence Berkeley National Laboratory in California. He moved to The Ohio State University in 2000. He held multiple leadership roles at Ohio State, including executive director of The Ohio State University Comprehensive Wound Center and director of the universitys Center for Regenerative Medicine & Cell Based Therapies.

At IU, he is a professor of surgery with tenure and holds the J. Stanley Battersby Chair. He is also associate vice president for military and applied research for Indiana University; associate dean for entrepreneurship for the IU School of Medicine; professor of biomedical engineering by courtesy at Purdue University; and associate director for technology and innovation for the Indiana Clinical and Translational Sciences Institute.

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What is regenerative medicine?

Losing the use of your voice box, or larynx, can be devastating. It affects your ability to speak, swallow and breathe, and can also dampen your sense of smell and make it difficult to cough. MRC scientists in London are now working on an extraordinary new treatment to help over two thousand people who suffer with serious larynx problems each year. Using stem cells, they are partially rebuilding the larynxas a potential replacement organ for patients.

This ground-breaking research is an example of the work being undertaken in regenerative medicine a branch of science that seeks to repair or replace damaged and diseased human cells and tissues. This may involve transplanting stem cells or tissues that have been grown in the lab, such as the larynx, or stimulating the body to repair itself. Regenerative medicine has the potential to completely change the way we care for patients by helping us to develop new treatments for a wide range of debilitating conditions.

At the heart of regenerative medicine is research using stem cells. These are cells that can regenerate almost indefinitely. Some, known as pluripotent stem cells, can develop into any of the cell types in the body. This extraordinary flexibility means they have the potential to treat many different diseases and conditions that currently have no cure, like type 1 diabetes, blindness, Parkinsons disease, heart disease and arthritis.

Creating new cells to replace dead or damaged tissue is known as stem cell therapy. Professor Robin Ali is an MRC-funded scientist at University College Londonwho is exploring the use of stem cell therapy for restoring eyesight in patients with degenerative retinal disease. By producing new, healthy retinal cells and injecting them into a patient with the disease, Robin hopes to find out if the therapy will be safe and effective to use in future. So far it has been successfully tested in mice, and now Robins work is moving towards clinical trials. Theres little more we can learn by treating another mouse. The most exciting science now is in patients and seeing just how effectively the technology can work in people, says Robin.

Professor Robin Ali is an MRC-funded scientist working at the forefront of regenerative medicine to find new therapies for people with degenerative eye conditions.

Stem cells are also being used to improve our understanding of how degenerative diseases develop and progress. This will help scientists to find drugs that can slow down the symptoms of these diseases, prevent them from getting worse, and even reverse them. A specific type of adult stem cell, called an induced pluripotent stem (iPS) cell, is essential to this work. iPS cells are created from ordinary skin, blood or hair cells by winding back the clock and reprogramming them to become stem cells. They are then able to develop into many different cell types that can be used in the lab to study disease. This approach has been used to recreate nerve cells from patients who are suffering with conditions like Parkinsons and Alzheimers disease, and cardiac cells from patients with heart disease. Scientists can study these cells more closely and use them to develop and test drugs something which is impossible to do in living patients.

Research in regenerative medicine is already having a huge impact in the clinic. Though sometimes overlooked, bone marrow transplants using blood stem cells are a well-established treatment for leukaemia. There are also a number of new regenerative therapies that are being used to help patients in the clinic. For example, there are skin regeneration treatments for burns patients and people with diabetic ulcers, treatments for anaemia and cartilage damage, and new options for reconstructive surgery.

Work is now underway to develop potential future treatments. One approach is looking at whether transplanting adult cells can stimulate damaged tissue to repair itself. Stuart Forbes, at the MRC Centre for Regenerative Medicine in Edinburgh, is investigating how cells called macrophages, which are extracted from patients bone marrow, can be used to encourage damaged liver cells to repair themselves. Another MRC-funded clinical trial has shown how this type of cell therapy can stimulate the self-repair of nerve cells, restoring limb movement in dogsthat have injured their spines. Efforts are now focused on how to use this technique to help human patients.

In a second approach, researchers are transplanting specific cell types or tissue grown in the lab to actively repair damage. This is where the use of pluripotent stem cells in particular, human embryonic stem cells (hESC) has the most potential. The first hESC-based clinical trial has just started in the UK to treat the juvenile eye condition, Stargardts macular dystrophy. Another trial, led by Professor Pete Coffey at University College London, will test the use of hESC to treat age-related macular degeneration. This is a degenerative condition leading to blindness which affects around 1 in 4 people over the age of 60 in the UK.

MRC scientists are also using hESCs in other disease areas. Tilo Kunath, at the University of Edinburgh, is creating dopamine-releasing brain cells from hESCs that can be used as potential cell transplants to treat patients with Parkinsons Disease. And at the University of Sheffield, Marcelo Rivolta is exploring new ways of treating congenital deafness, which affects 1 in every 1,000 children, by replacing the sensory hair cells in the inner ear. Marcelos team has shown that these cells, when grown from hESCs, can be transplanted to restore hearing in gerbils. They are now looking to develop this approach into a treatment for humans.

Promoting stem cell research and regenerative medicine is a priority for the MRC. We have supported pioneering stem cell research since the field first emerged, and remain at the forefront of regenerative medicine. In the 1980s we funded Sir Martin Evans Nobel Prize-winning work to isolate and genetically manipulate embryonic stem cells for the first time, and today our scientists are investigating the use of stem cells to treat blindness, heart disease and neurodegenerative diseases such as Parkinsons disease and Multiple Sclerosis.

We are the main funder of regenerative medicine research in the UK, and spend in the region of 40 million per year in this area. Our work is guided by a Strategy for UK Regenerative Medicine (PDF, 1.60MB) which describes the many opportunities and challenges faced by the field. As well as supporting individual teams of scientists, we have invested in MRC research centres, units and institutes across the UK such as those in Edinburgh, London, Oxford and Cambridge.

The UK Regenerative Medicine Platform launched in 2013

The field of regenerative medicine faces many technical and scientific challenges. These include understanding how to turn stem cells into the type of cell needed and how to manufacture them safely and in large-enough quantities for use in the clinic. It is also crucial to figure out how to target treatments to the part of the body that needs repairing, and to find ways of stopping the body from rejecting transplants.

To tackle these and other obstacles, we helped to launch the UK Regenerative Medicine Platform (UKRMP)in 2013, together with BBSRC and EPSRC. This 25 million initiative has brought together leading research teams from different universities and different areas of science such as biology, medicine and engineering. This will help to ensure that promising scientific discoveries in regenerative medicine are translated into the clinic where they can benefit patients. The UKRMP will work closely with the newly established Innovate UK'sCell Therapy Catapult, which promotes the commercialisation and late-stage development of regenerative medicine products, as well as with research charities and other stakeholders.

It is important that researchers can access and use human stem cells that are ethically-sourced and reliable. We play a leading role in this area by making sure that UK human embryonic stem cell (hESC) research is appropriately regulated. Our activity includes MRC funding for the UK Stem Cell Bank the worlds first which provides ethical and high-quality hESC lines that scientists in the UK and overseas can use for laboratory and clinical work. These hESC lines must be produced to the highest quality in order to be used in patient studies. To help with this, we have funded three centres to produce more than 20 hESC lines that are now being used in clinical studies (see From the lab to the clinic).

As well as the UK Stem Cell Bank, we established the Human Induced Pluripotent Stem Cell Initiative (HIPSCI) in 2013, together with Wellcome Trust. HIPSCI is creating a catalogue of iPS cells from over 500 healthy volunteers and 500 patients with genetic disease. These cells will be made available to scientists who want to do laboratory research on the effects of our genes on health and disease. Their work will help us to understand how iPS cells can be controlled and used in future stem cell therapies.

Our work in regenerative medicine is not limited just to the UK. In the past three years, we have collaborated with the US and China on stem cell research. Together with the Californian Institute of Regenerative Medicine in the US, we are addressing new approaches for treating age-related macular degeneration and acute myeloid leukaemia. We are also working with the National Natural Science Foundation of China on a number of projects that link the best UK and Chinese labs in stem cell research.

Professor Peter Andrews is an MRC-funded scientist who coordinates the International Stem Cell Initiative. His research in the lab focuses on the science behind stem cell therapies.

Our membership in the International Stem Cell Funders Forum (ISCF), which brings together the worlds major biomedical funding organisations, has allowed us to take a leading role in encouraging international working, sharing resources, and helping to establish best practice among researchers. An example of this is the International Stem Cell Initiative (ISCI) project, led by Professor Peter Andrewsat the University of Sheffield Centre. ISCI was set up to shed light on the factors that influence stem cell growth and behaviour. It does this by bringing together labs from across the globe to share data and resources. Work by ISCI has helped to identify unstable regions within the chromosomes of pluripotent stem cell lines, which need to be controlled if the lines are to be used as therapies in the future.

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Regenerative Medicine is; at its core, a conservative therapy. We do not utilize drugs, surgery or foreign materials to treat your painful condition. We use your very own cells to naturally repair and regenerate the affected tissues to reverse the damage. Powerful cells in your bone marrow called Mesenchymal Stem Cells can change and grow into new muscle, tendon, ligament, bone and even cartilage when called upon by the body. Growth factors provided by the platelets in your blood further stimulate and enhance this process. Marrow is harvested from the bone at the back of your waist through a relatively gentle, low volume aspiration.

From a simple blood draw, we can concentrate the platelets in a centrifuge. The combined injectate is skillfully targeted to the area needing treatment using state-of-the-art imaging techniques. In a time when we are flooded with more drugs and supplements than ever offering to treat injury and pain, people are demanding organic remedies and more natural cures. We are extremely proud to add this fantastic therapy to the already comprehensive list of services provided.

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Summit Regenerative Medicine

Call or text 941-794-5868, email, orclick the link belowto make anappointmentor request more information:

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Regenerative medicine technologies are relatively new forms of treatment designed to enhance your bodys ability to heal itself. These treatments use natural substances that modify your natural healing mechanisms to help joints, tendons and ligaments heal and repair themselves.

There are three branches of regenerative medicine: Rejuvenation, Replacements, and Regeneration.

There are 3 types of regenerative medicine offered at our centers, including:

PRP is a mixture of growth factors and other proteins found in the platelets of your own blood. These platelets migrate to areas of injury in the body and initiate and enhance a healing response. PRP treatments utilize a technology where we draw your own blood, concentrate the platelets and growth factors, and inject them back into the body at sites of injury or degeneration. These proteins enhance the activity of the healing mechanisms and decrease the mediators of inflammation to help make a patient feel better and heal the injury.Download more information

Cell-based therapy is a mixture of growth factors, proteins and mesenchymal stem cells that are found naturally in the body. These substances can be harvested from either your fat or bone marrow and injected into areas of injury or degeneration to enhance healing and ongoing repair. These mesenchymal stem cells have the ability to differentiate into other types of cells and continue to help your healing over the long term. Download more information

Amniotic products use either fluid or tissue to protect, cushion and reduce inflammation in joints and tendons. Amniotic tissue contains bioactive proteins harvested from healthy voluntary donors and therefore allows this procedure to be minimally invasive. Download more information

I am a 52-year-old physician and CrossFit athlete. Dr. Arthur Valadie surgically repaired my left knee 12 years ago. The outcome was excellent. Recently, he injected stem cells in the same knee. My knee feels fantastic and there is no exercise I cant perform!

After two years of shoulder pain, Dr. Valadie offered the Lipogems stem cell therapy as an alternative to conventional rotator cuff surgery. I am now 90+ days removed from the procedure and honestly amazed with the result. Im 80% back to my pre-injury condition. I cannot recommend Dr. Valadie, his team and this procedure highly enough. Simply incredible. Thank you!

I have suffered with osteoarthritis for three years in my right knee. After having the stem cell replacement procedure in November 2017, I have less pain and inflammation in the knee. I have much more ease with daily activities and continue to see improvement. The procedure was simple and painless. There was some discomfort after, but only within the first 24 hours.

PRP treatments are most effective for chronic ligament and tendon sprains and strains, that have failed other forms of treatments. Some of the treatments that can benefit from PRP include:

In addition to the list above PRP can also be effective in osteoarthritis cases, by stimulating the healing process of the cartilage, which reduces the pain. The areas that can benefit from PRP include:

First, a small amount of blood is drawn from the patient. Preparation of the solutions can take 25-30 minutes. Once the blood is drawn, it is placed in a machine called a centrifuge, that spins the blood at a high speed. This machine helps separate the blood into red blood cells and concentrated platelets. Once the blood is separated from the platelets, the blood is discarded and what remains is a concentrated platelet-rich plasma, known as PRP.

A stem cell is a cell with the unique ability to develop into specialized cell types in the body. They may be used to help your body heal tissues that have been damaged due to injury or degeneration.

These cells can be harvested from adipose tissue (body fat) or bone marrow with a relatively minor procedure. This is done under local anesthetic to minimize the pain of harvesting. Discomfort from the harvest is usually relatively mild.

Mesenchymal stem cell injections help the body heal itself. The cells can turn into cell types appropriate for the body part which can then help aid in the healing process. These injections are significantly less invasive than surgery and can shorten recovery time and diminish the risks compared to traditional treatments.

There are four types of Cell-Based Therapy that use the latest biological drugs with anti-inflammation agents and steroids, used for inflammatory bowel disease (IBD). The goal for these four therapies is to cure IBD, cell-based therapies offer hope to patients when traditional treatments have failed.

This type of injection is a minimally-manipulated injectable allograft designed to reduce inflammation as well as to protect, cushion, and lubricate joints and tendons.

While a baby is in the womb, it is situated within the amniotic sac. Inside the sac, the baby is surrounded by amniotic fluid. Amniotic fluid is gathered by a relatively easy, minimally invasive procedure from a willing donor, that is neither harmful to the mother or baby.

These injections can counteract inflammation and the harmful proteins that can cause joint pain. This diminished inflammation as well as lubrication can decrease pain and improve function.

We are in the pioneering days of regenerative medicine. Compared to other traditional medical treatments, regenerative medicine treatments have fewer clinical studies because of the relatively recent development of these technologies. We use and follow all available clinical studies regarding these treatments, so we can provide evidence-based ethical regenerative medicine treatments. These treatments are provided by board-certified, fellowship-trained orthopedic surgeons and spine/pain management physicians.

No, insurance does not cover regenerative medicine treatments as it is a relatively new field of medicine. Fortunately, there are many pricing options depending on the treatment you choose.

These are non-surgical treatments. Depending on the mode of treatment, tissue can be obtained either from a healthy donor, a simple blood draw, or a slightly more invasive procedure to obtain mesenchymal stem cells depending on the treatment you choose.

While the complete healing process can take several months, the downtime after the procedure is extremely minimal compared to that of surgery recovery.

If you want to learn more about regenerative medicine, please dont hesitate to contact us. At Coastal Orthopedics, we offer same-day appointments at three locations across Bradenton, Florida to serve you better.

Contact Our Regenerative Medicine Concierge TodayCall Coastal Orthopedics at941-794-5868

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Cord Blood & Regenerative Medicine

The therapeutic potential of cord blood continues to grow.

Regenerative medicine is the science of living cells being used to potentially regenerate or facilitate the repair of cells damaged by disease, genetics, injury or simply aging by stimulating the body's own repair mechanisms.

Why cord blood?

Think about it: the natural power and purity of your newborn's cord blood are responsible for healthy development during pregnancy. So it makes sense that they are the ones most likely to be called upon when studying ways in which science can help restore health.

Cord blood is being used in clinical trials for autism and cerebral palsy.

Over the last few years, cord blood applications have expanded beyond transplant medicine into areas of regenerative medicine in clinical research trials for autism and brain injuries.

After demonstrating that it's safe for children with Autism Spectrum Disorder (ASD) to receive cord blood, a clinical trial is now underway to determine the effects of using a child's own cord blood or unrelated donor cord blood in children with autism. ViaCord families are participating in this innovative research to help kids with conditions once thought untreatable.

Learn more about cord blood and autism

A clinical trial at Duke University recently showed that an infusion of a child's own cord blood appears to improve brain connectivity and motor function in children with cerebral palsy. Twenty ViaCord families participated in this exciting research. Results were published in Stem Cell Translational Medicine. A third study is now underway to determine the safety of using a sibling's cord blood.

Learn more about cord blood and cerebral palsy

Brain Injury:Stroke 68 andHypoxic-IschemicEncephalopathy (HI) 108

Cardiac: Hypoplastic Left Heart Syndrome (HLHS)119

Hearing:Acquired Hearing Loss118

Autoimmune Deficiencies:Type 1 Diabetes84

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Cord Blood and Regenerative Medicine | ViaCord

Regenerative Medicine at Seattle Sports & Regenerative Medicine includes the collection and use of therapeutic stem cells to regrow, repair, or replace damaged or diseased tissue within the musculoskeletal system, including: shoulders, elbows, wrists, hips, knees, and ankles.

As your physician, Dr. Wagner is committed to providing the highest level of care, priding himself on staying connected to the ever-changing medical community and the most advanced medical technology available. It is his promise, as your physician, to responsibly provide the most progressive treatments, as long as he is completely confident that they are safe and beneficial for his patients.

Stem cell therapy and Platelet Rich Plasma (PRP) injections are both offered to alleviate pain and repair injury in the bodys tendons and joints, proving to be very effective in such conditions as osteoarthritis, tendon injuries, meniscus and labrum tears. Over 5 million stem cell procedures for osteoarthritis have been performed in the United States with no significant adverse effects reported.

We understand that the use of stem cells may sound complex, however, stem cell therapy is just the opposite. It is a simple procedure, performed in our office during a visit lasting approximately 90 minutes. If you have questions or would like a consultation with Dr. Wagner to learn if you are a candidate for stem cell therapy, please contact Seattle Sports and Regenerative Medicine.

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Seattle Stem Cell Therapy Clinic - Regenerative Medicine

by admin on March 23, 2018 No comments

By: Matthew Fischer

The regenerative medicine arena consists of a wide range of innovative products. Congress, acknowledging the importance of this field, has established a new program via the 21st Century Cures Act to help spur development and provide for accelerated approval for regenerative medicine products similar to the FDAs fast track and breakthrough therapy designations. This new approval is the Regenerative Medicine Advanced Therapy (RMAT) Designation.

The RMAT Designation includes all the benefits of the FDAs other accelerated designations including early agency engagement and priority review; however, unlike the other designations, the RMAT Designation does not require evidence that the product offers substantial improvement over other therapies. For a drug to be eligible for the RMAT Designation, it must meet the following:

The Code of Federal Regulations sets forth specific guidelines for the designation request process. The office within the FDA tasked with reviewing these requests is the Office of Tissues and Advanced Therapies (OTAT).

In November 2017, the FDA issued draft guidance regarding this expedited program requesting comment from the industry. At the time, the FDA indicated that the agency had received 34 designation requests and acted on 31 of the requests. With this new regulatory framework and specific pathway, the FDA seeks to set the stage for the future with the goal of addressing unmet medical needs with reduced product development time.

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Non-Operative Solutions for Orthopaedic Pain

Regenerative Medicine refers to the processes by which specialized technology is used to create living, functional tissues to replace or repair tissue that has been lost due to damage, disease, or hereditary defects. For those struggling with limited mobility due to arthritis, injury, tendinopathy (disease of the tendons), or other forms of musculoskeletal inflammation, patients may be able to experience relief and avoid surgery by harnessing the healing potential of their own cells.

Adipose-Derived Cell TherapiesThis method utilizes fat cells, which have high concentrations of stem cells and other growth factors within them, to decrease inflammation and aid in healing. In a minimally invasive procedure, a doctor will retrieve a patients own fat cells and deposit them into a device that uses a saline agent to rid the cells of blood and oil. At that point, the fat tissue has been resized and holds the ideal material and performance properties to stimulate healing. The doctor will then inject the fat graft into the joint experiencing the arthritic pain to decrease inflammation and encourage healing.

Platelet Rich PlasmaCommonly referred to as PRP, platelet rich plasma utilizes a patients own blood to produce growth factors. Growth factors are naturally occurring proteins that bind to the cells in your body and stimulate growth, healing, and repopulation. With this minimally invasive procedure, a doctor will draw the patients blood and spin it in a centrifuge to separate the blood into layers. The layer, which is rich with growth factors and platelets, is extracted and reintroduced into the damaged joint to encourage healing and reduce inflammation.

Bone Marrow AspirateBone marrow the soft, spongy tissue found in the center of large bones is composed of both fluid and solid matter. It is rich in growth factors and regenerative stem cells. Unlike other cells in the body, these cells are able to replicate themselves into various types of tissue for healing. To utilize bone marrow to stimulate healing and regrowth in an arthritic joint, a doctor will extract bone marrow fluid (called aspirate) from a healthy bone in the body, generally the pelvis, and place it in a centrifuge to generate a concentration of powerful cells. These cells are then reintroduced into the arthritic joint to repair damaged tissue and decrease inflammation.

These procedures are some of the newest treatments available today. They offer patients a minimally invasive option to help relieve the pain of arthritis or injury and improve function. Our highly skilled medical doctors use state-of-the-art diagnostic tools, including musculoskeletal untrasound, high-definition on-site MRI, and X-ray, to obtain pinpoint accuracy during the procedures.

Make an appointment with one of our industry-leading physicians today to see if Regenerative Medicine is an option for you by calling (423) 697-8780.

The physicians at Center for Sports Medicine and Orthopaedics are highly regarded as leaders in their profession, not only in Chattanooga, but in the Southeast region. They continue to be at the forefront of offering patients the latest medical procedures and treatments toward ensuring the best possible outcomes. We are excited to offer our patients an innovative approach to treating pain and healing.

At Center for Sports Medicine & Orthopaedics, our highly trained and compassionate staff takes pride in providing personalized care to all of our patients. That starts with a full orthopaedic evaluation with one of our doctors to assess your needs and evaluate your treatment options. We have specialists who focus on specific areas of the body including the spine, shoulder, hand, elbow, hip, knee, foot and ankle.

Make an appointment with one of our industry-leading physicians today to see if Regenerative Medicine is an option for you by calling (423) 697-8780.

regenerativemed@sportmed.com2415 McCallie AvenueChattanooga, Tennessee 37404

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Regenerative Medicine - sportmed.com

What regenerative medicine options do you offer?

DMOS offers three types of regenerative medicine options, all commonly used to treat different musculoskeletal conditions, including arthritis, muscle strains, tendon and ligament injuries.

The injection type differs based on the patient assessment and their individualized needs.

By definition, PRP is a collection of growth factors (which are proteins that are important in the healing of injuries), that can have controlled levels of white and red blood cells, based on the healing process necessary. Laboratory studies have shown that the increased concentration of growth factors in PRP can potentially speed up the healing process. Many world-class athletes use PRP therapy to repair their sports injuries faster.

Technically, BMAC is a collection of growth factors and cells, which include stem cells. Physicians use BMAC when they believe the potential upside of containing mesenchymal stem cells (MSCs) is necessary for treatment.

This injection serves to help as a local anti-inflammatory and reset the bodys natural balance in the arthritic joint. In technical terms, APS is a denatured PRP that delivers proteins, which block arthritic pain receptors. APS may be the preferred course of treatment based on if the patient exhibits radiographic evidence of knee, hip or shoulder OA (osteoarthritis).

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Regenerative Medicine - DMOS - Des Moines Orthopedic Centers

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT).

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues. The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it. The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury. Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery. Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:

Prolotherapy:

This treatment involves injecting a proliferant (usually dextrose) into weakened or injured joints, ligaments, or tendons. With a precise injection of a mild irritant solution directly on the site of injury, prolotherapy creates a mild, controlled inflammation that stimulates the bodys natural healing mechanism to lay down new tissue on the weakened area. Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain. Injection sessions are done 3-6 weeks apart, and usually a series of 3 injection sessions is done and then the response is assessed. The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves. They can be used for any part of the body where nerve pain exists. After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.

Platelet Rich Plasma Therapy (PRP):

During PRP therapy, a small vial of your own blood is drawn and placed in a centrifuge to separate the platelet-rich plasma from other blood components. This highly concentrated platelet-rich layer contains growth factors and a variety of cells. Growth factors stimulate local cells for tissue repair and remodeling. Your PRP is injected into and around the area of injury. Several injections may be done at the injured site at one time to fully treat the area. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Cell Therapy:

Stem cells(MSCs) are readily available and can be harvested from your bone marrow through a needle. Once injected into an area of injury, MSCs secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle. MSCs can be thought of as the manager of your bodys innate healing potential. Many times only one injection is needed. If there is an incomplete response to treatment additional injections may be advised.

Lipoaspirate (Fat) Graft:

Lipo aspirate therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic. It is especially effective for areas where there are soft tissue defects such as tears or arthritis. This type of injection is used in collaboration with PRP or bone marrow aspirate cell injections, which deliver growth factors to the injured area.

Alpha 2 Macroglobulin (A2M):

A2M is a naturally occurring molecule found in your blood that acts as a powerful protector against cartilage breakdown and progression of arthritis. A small vial of your own blood is drawn and placed in a centrifuge to separate the blood components, then is injected. A2M attaches to and removes the destructive enzymes that damage cartilage cells in the joint. The A2M is soothing to the joint and acts like a natural anti-inflammatory.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids. Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment. The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.

What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background. Rene S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function. With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine. Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.

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Syracuse Regenerative Medicine

Regenerative medicine promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells. Researchers prepare the stem cells in a lab beforehand, and are manipulated to specialize into specific types of cells, such as heart muscle cells, blood cells or nerve cells. While Stem cell therapy requires no invasive surgery, these stem cells called placental-derived mesenchymal stem cells (MSCs) are prepared beforehand, and injected directly into the area of pain or injury of your joint, muscle, ligament, or tendon. This procedures objective is simply to relieve pain, while the new stem cells stimulate your body to repair itself and heal faster, by generating healthy tissue. Stem cell therapy has recently had a major breakthrough within the medical field, particularly in the field of Orthopedics, due to the potential of these stem cells ability to allow the body to heal itself, and possibly eliminate arthritis pain and other chronic or acute pain from injuries. Benefits of Regenerative Medicine:

What is it? Platelet-rich plasma (PRP) therapy is a revolutionary procedure that uses components of the bodys own blood cells to stimulate the natural healing process in certain orthopedic conditions.The bodys first response to any soft tissue injury (ligaments and tendons) is to deliver platelet cells. Filled with healing and growth factors, the platelets jump-start the repair process. The platelets are separated from the rest of the blood cells and put through a process called centrifugation, which increases the platelets concentration. These platelets are then injected into the area needed with different concentrations of other cells to enhance the bodies healing process and decrease pain. This quick procedure can also provide effective pain relief, eliminating the need for surgery and prolonged recovery.

If you are a candidate for regenerative medicine or PRP therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

Amniotic tissue has been used for many years to treat a variety of medical issues and has had excellent results. More recently there has been application to orthopedic issues such as arthritis and tendon/ligament healing. The amniotic membrane is a layer of the amniotic sac, which is donated after birth and does not contain fetal tissue. It is dehydrated and stored and then rehydrated at the time of injection. The process is very simple and similar to a cortisone injection. The injection can decrease inflammation and promote healing through multiple growth factors. It is safe and very effective.

Many orthopedic conditions can be treated with PRP or Amnitoic Membrane injections, including chronic pain and stiffness associated with osteoarthritis. If you have pain, limited mobility, swelling, or sports injuries, chances are regenerative medicine therapy can benefit you, and has shown promising results, treating these common conditions:

If you are a candidate for regenerative medicine therapy, call Midwest Orthopaedics in Shawnee Mission or Overland Park, Kansas at(913) 362-8317orrequest an appointment online.

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Regenerative Medicine | PRP Therapy | Midwest Orthopaedics

Introduction

During the natural aging process of the human body, several organs and tissues undergo a large anabolic phase (during the first 3 decades of life) and they soon develop into a catabolic phase, which is slower and irreversible (from the 4th to the final decades of life).In the anabolic phase the skin is shiny, silky, has elasticity and a large turgor. There is a large volume of toned muscular mass.The catabolic phase starts in the fourth decade of life and acceleratesin many cases during the seventh decade . In this phase there is an absence of skin sheen and the appearance of wrinkles and senile spots (the dernal layer also starts to show signs of weakness, and this occurs because of the decrease of the proteins that make up the skins elastic system, such as collagen and glycosaminoglycan / GAG).Muscular mass loses its volume and tone progressively, causing the body to show visible signs of aging. Probably a high protein diet may be responsible for the final quality of our organs and tissues during the anabolic phase causing the body to be more resistant and durable. This high protein diet, when applied during the catabolic phase, can maintain a better skin quality and improved muscular mass.During the past 10 years, we have endeavored to understand the consequences of the different intrinsicand extrinsic processes that alter the harmony of the movements of the muscles of the lower third of the face.

The outline of the mouth is made from a complex muscular system, where the

muscle of the mouth actively links with the

muscles that tighten the angle of the mouth sideways,

acts in a secondary fashion in this muscular complex. One can easily see, by way of a systematic evaluation of these muscles, (movements such as :whistling, smiling, making a sad face, and pulling a face as if having a bitter taste in the mouth) .Each patient can present important asymmetrical and accented depressions, caused by the exaggerated contraction of some of these muscles.

Till today,these facial defects have been treated with facial implants (fillers) and some serious cases have been even treated using classical surgical procedures : Fillers as surgery didn t revolve the problems !

Our proposal is to demonstrate that, by way of a selective intramuscular injection, of an oily patented solution containing a mixture of Carbolic Acid with Peanut Oil Acid using endopeel technology created by inventors Dr.Alain Tenenbaum ( facial plastic surgeon) and Mauro Tiziani ( molecular biologist) , it is possible to decrease the force of one or more muscles, that are working harder and in disharmony with the other muscles in the complex muscular system around the mouth.

We believe that the mechanism that is developed, after the injection of the ,,Endopeel,, oily solution, is a selective pointed chemical reversible myolysis, limited within the injected area of the muscular mass. With preliminary tissue studies, we can see that this myolysis is totally reversible after 7 months.

We have acquired experience from more than 1000 clinical cases over the past 8 years. The majority of these patients were re-treated in the same muscles that were treated earlier. The average re-treatment period was 4-6 months, and usually, smaller doses of the patented oily solution were injected, due to the hyperfunction of the muscles movements being attenuated. The average dose per injection is about 0.05 ml and the distance between each point is approximatively 1.0 centimeter.

We found that this treatment is very efficacious as long as there is a clear and precise evaluation of the above mentioned muscle system.

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Endopeel Portal Main Website : Lifting,Tightening & Tissue ...

Regenerative medicine is a game-changer in the world of medicine. Treatments include: Stem Cell Therapy, PRP (Platelet Rich Plasma) Therapy and Amniotic Stem Cell Therapy (Amnion). Each custom treatment option may help to heal damaged tissues and organs, offering solutions and hope for people whose conditions have proven beyond repair previously.

I didnt know anything about PRP when I went to my appointment with Dr. Hall. I was able to do some research before I had anything done. The stem cells come from my own bone marrow. Stem cell treatment is fairly new, but shows positive results. I decided that it was something that could help me. I trust Dr. Hall. Dr. Hall removed the stem cells from my hip and injected them into my knees while I was in surgery under anesthesia.

I was in physical therapy after the surgery. Now Im back in the gym three days a week, exercising on the elliptical machine, weight training and in yoga classes. I walk five miles four or five days a week.

In six weeks, I was at 133 degrees range of motion, which was only 4 degrees behind my good leg. I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.I attribute my advanced recovery to the outstanding hands of the DOC surgeon, the PRP/stem cell therapy, and Mike at ATI Physical Therapy.

If you are reading this testimonial and questioning whether the extra money spent on the PRP and stem cell therapy are worth it, I would highly recommend that you take out a loan if necessary in order to benefit from this healing therapy.

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Regenerative Medicine - directorthocare.com

Though great progress has been made in medicine, current evidence-based and palliative treatments are increasingly unable to keep pace with patients' needs, especially given our aging population. There are few effective ways to treat the root causes of many diseases, injuries and congenital conditions. In many cases, clinicians can only manage patients' symptoms using medications or devices.

Regenerative medicine is a game-changing area of medicine with the potential to fully heal damaged tissues and organs, offering solutions and hope for people who have conditions that today are beyond repair.

Regenerative medicine itself isn't new the first bone marrow and solid-organ transplants were done decades ago. But advances in developmental and cell biology, immunology, and other fields have unlocked new opportunities to refine existing regenerative therapies and develop novel ones.

The Center for Regenerative Medicine takes three interrelated approaches:

Rejuvenation. Rejuvenation means boosting the body's natural ability to heal itself. Though after a cut your skin heals within a few days, other organs don't repair themselves as readily.

But cells in the body once thought to be no longer able to divide (terminally differentiated) including the highly specialized cells constituting the heart, lungs and nerves have been shown to be able to remodel and possess some ability to self-heal. Teams within the center are studying how to enhance self-healing processes.

Replacement. Replacement involves using healthy cells, tissues or organs from a living or deceased donor to replace damaged ones. Organ transplants, such as heart and liver transplants, are good examples.

The center aims to expand opportunities for transplants by finding ways to overcome the ongoing donor shortage, the need for immunosuppression and challenges with organ rejection.

Regenerative medicine holds the promise of definitive, affordable health care solutions that heal the body from within.

Stem cells have the ability to develop through a process called differentiation into many different types of cells, such as skin cells, brain cells, lung cells and so on. Stem cells are a key component of regenerative medicine, as they open the door to new clinical applications.

Regenerative medicine teams are studying a variety of stem cells, including adult and embryonic stem cells. Also being studied are various types of progenitor cells, such as those found in umbilical cord blood, and bioengineered cells called induced pluripotent stem cells. Each type has unique qualities, with some being more versatile than others.

Many of the regenerative therapies under development in the Center for Regenerative Medicine begin with the particular patient's own cells. For example, a patient's own skin cells may be collected, reprogrammed in a laboratory to give them certain characteristics, and delivered back to the patient to treat his or her disease.

Stem cells and their use in regenerative medicine have been in the media a lot lately. But what exactly does it mean? Physicians and researchers in the Center for Regenerative Medicine say it has to do with developing completely new ways to treat and manage chronic diseases such as diabetes, heart failure, and degenerative nerve, bone and joint conditions.

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About Regenerative Medicine - Center for Regenerative ...

Regenerative medicine seeks to replace tissue or organs that have been damaged by disease, trauma, or congenital issues, vs. the current clinical strategy that focuses primarily on treating the symptoms. The tools used to realize these outcomes are tissue engineering, cellular therapies, and medical devices and artificial organs.

Combinations of these approaches can amplify our natural healing process in the places it is needed most, or take over the function of a permanently damaged organ. Regenerative medicine is a relatively new field that brings together experts in biology, chemistry, computer science, engineering, genetics, medicine, robotics, and other fields to find solutions to some of the most challenging medical problems faced by humankind.

When injured or invaded by disease, our bodies have the innate response to heal and defend. What if it was possible to harness the power of the body to heal and then accelerate it in a clinically relevant way? What if we could help the body heal better?

The promising field of Regenerative Medicine is working to restore structure and function of damaged tissues and organs. It is also working to create solutions for organs that become permanently damaged. The goal of this approach is to find a way to cure previously untreatable injuries and diseases.

1. Tissue Engineering and BiomaterialsTissue engineering is a strategy where biologically compatible scaffolds are implanted in the body at the site where new tissue is to be formed. If the scaffold is in the geometric shape of the tissue that needs to be generated, and the scaffold attracts cells the outcome is new tissue in the shape desired. If the newly forming tissue is subjected to exercise as it forms, the outcome can be new functional engineered issue.

Millions of patients have been treated with some form of tissue engineered devices, yet the field is in its infancy. The primary success stories have been with soft tissue regeneration. To learn more about some of the promising studies and clinical trials involving tissue engineering,click here.

2. Cellular TherapiesMany millions of adult stem cells are found in every human. Our body uses stem cells as one way of repairing itself. Studies have illustrated that if adult stem cells are harvested and then injected at the site of diseased or damaged tissue, reconstruction of the tissue is feasible under the right circumstances. These cells can be collected from blood, fat, bone marrow, dental pulp, skeletal muscle and other sources. Cord blood provides yet another source of adult stem cells. Scientists and clinicians are developing and refining their ability to prepare harvested stem cells to be injected into patients to repair diseased or damaged tissue.

To learn more about some of the promising studies and clinical trials involving cellular therapies,click here.

3. Medical Devices and Artificial OrgansIn cases where an organ fails, the predominant clinical strategy is to transplant a replacement organ from a donor. The principal challenges are the availability of donor organs, and the requirement that the donor take immunosuppression drugswhich have side effects. Further, there are many instances where the time to find a suitable donor organ requires an interim strategy to support or supplement the function of the failing organ until a transplantable organ is found. Using circulatory support as an example, there are technologies in various stages of maturity, initially using ventricular assist devices (VADs) as a bridge to a heart transplant, and now there are VADs that are used for long-term circulatory support (destination therapy).

Scientists and clinicians around the world are developing and evaluation devices to supplement or to replace the function of many organ systems including the heart, lung, liver and kidney.

To learn more about some of the promising studies and clinical trials involving medical devices and artificial organs, click here.

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What Is Regenerative Medicine? | Regenerative Medicine at ...

New Video Series - Watch Now

Scroll down to get an inside look into the lab and hear directly from our scientists about their projects aimed at helping patients with conditions such as diabetes, lung disease, hemophilia A and gastrointestinal disorders.

An International Leader in Regenerative Medicine

The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies. Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies - all with the goal to cure, rather than merely treat, disease.

The Next Evolution of Medical Treatments

Regenerative medicine has been called the "next evolution of medical treatments," by the U.S. Department of Health and Human Services. With its potential to heal, this new field of science is expected to revolutionize health care. It is our mission at WFIRM to improve patients' lives by developing regenerative medicine therapies and support technologies.

"We have many challenges to meet, but are optimistic about the ability of the field to have a significant impact on human health. We believe regenerative medicine promises to be one of the most pervasive influences on public health in the modern era."-Anthony Atala, MD, Director

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Wake Forest Institute for Regenerative Medicine (WFIRM ...