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Archive for the ‘Preventative Medicine’ Category

Antibody study aims to protect those exposed to coronavirus from illness – The Jerusalem Post

Monday, December 28th, 2020

Two new clinical trials in the UK are examining whether administering an antibody combination after someone has already been exposed to the novel coronavirus could protect them from developing COVID-19, the disease caused by the virus.

The University College London Hospitals (UCLH) NHS Trust announced on Friday that it is running the trials at a new vaccine research center.

Both trials are examining AZD7442, a long-acting antibody (LAAB) combination developed by AstraZeneca.

The first study, called STORM CHASER, is examining whether the antibody can provide immediate and long-term protection to people recently exposed to the SARS-CoV-2 virus.

We know that this antibody combination can neutralize the virus, so we hope to find that giving this treatment via injection can lead to immediate protection against the development of COVID-19 in people who have been exposed when it would be too late to offer a vaccine, said study leader UCLH virologist Dr. Catherine Houlihan in a press release from the hospital.

STORM CHASER had recruited 10 people as of Friday. Key participants will include healthcare workers, students in group housing, patients exposed to anyone with the virus, residents of long-term care facilities and those in industrial or military settings.

THE SECOND study, called PROVENT, is examining whether people who may not respond to the vaccine, including immuno-compromised people, or at-risk groups, such as the elderly or those with preexisting conditions, may be helped by AZD7442, even prior to exposure.

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We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV, which may affect the ability of their immune system to respond to a vaccine," said UCLH infectious diseases consultant Dr. Nicky Longley, the head of the study. "We want to reassure anyone for whom a vaccine may not work that we can offer an alternative, which is just as protective.

Both UCLH studies will examine whether AZD7442 reduces the risk of developing COVID-19 and/or reduces the severity of the infection compared to a placebo.

Trial participants will be able to safely leave the study in order to get licensed vaccines if it is deemed medically beneficial, according to UCLH.

Antibodies are produced by the body to help fight infections. Monoclonal antibodies are artificially produced in laboratories for possible medical treatments in patients already infected with the virus and could provide protection before exposure as well.

While vaccines train the body over a matter of weeks to produce its own antibodies, antibody injections skip that step, aiming to provide immediate protection against viruses.

AZD7442 is a combination of two LAABs derived from recovering patients that were discovered by Vanderbilt University Medical Center and then licensed to AstraZeneca, according to the company, which then optimized the LAABs with half-life extension in order to increase the durability of the therapy for six to 12 months. The combination is also designed to reduce the risk of resistance developed by the virus.

In pre-clinical experiments published in Nature, the LAABs in AZD7442 were shown to block the novel coronavirus from binding with host cells, protecting against infection.

UCLH'S NEW Vaccine Research Center, which opened in December, is operating under the patronage of the National Institute of Health Research (NIHR) UCLH Biomedical Research Center and the UCLH Research Directorate, and represents an extension of the NIHR UCLH Clinical Research Facility led by Prof. Vincenzo Libri.

Libri is also a principal investigator on the Oxford/AstraZeneca vaccine trial and provides oversight of all COVID-19 vaccine/preventative treatment trials.

Mene Pangalos, AstraZeneca's executive vice president of BioPharmaceuticals Research & Development, stated in the UCLH release that AZD7442 has the potential to be an important preventative and therapeutic medicine against COVID-19, focusing on the most vulnerable patients."

"The STORM CHASER trial in particular is a unique approach, with enrollment initiated on site following the identification of a confirmed case to halt the spread of COVID-19 in the facility or community," Pangalos said. "We offer our appreciation and gratitude to everyone involved in these trials from the scientists, researchers and clinicians, to the trial participants and study sites as we all work together to help end this pandemic.

Antibody treatments have been evaluated since nearly the beginning of the pandemic.

In May, the Israel Institute for Biological Research (IIBR) completed a groundbreaking scientific development, identifying an antibody that neutralizes the coronavirus.

Maayan Jaffe-Hoffman, Anna Ahronheim and Idan Zonshine contributed to this report.

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Prairie People: New hires and promotions – Grand Forks Herald

Monday, December 28th, 2020

Dale Carnegie of North Dakota and Northwest Minnesota has new ownership

FARGO, N.D. Bethany Berkeley is now the CEO and co-owner of Dale Carnegie of North Dakota and Northwest Minnesota. She partners with Katie Munion, who is the chief transformation officer and co-owner.

Both women begin this journey with strategic focus, a wealth of experience and grateful hearts. Theyve been in the business and know the industry. Prior to ownership, Berkeley was the managing partner and president, and Munion was the vice president of training and quality.

They are excited to continue offering the core Dale Carnegie courses and in-house customized training solutions with a specialized focus on communication and interpersonal skills, presence and storytelling, sales and customer service excellence, leadership training for new and aspiring managers and experienced managers. All solutions are offered in versatile formats: in-person (socially distanced at minimum capacity), live-online, or blended.

They represent clients primarily in the manufacturing, distribution, engineering, construction, government, agriculture, technology, finance, and professional service industries. They also have a new space to collaborate and facilitate training solutions -- the Railyard at 1630 1st Ave. N. in Fargo.

Enclave welcomes two new team members

FARGO, N.D. Ashley Kossan has joined Enclave as accounts payable & receivable specialist.

A graduate of North Dakota State University, Kossan brings experience as an accountant, mortgage loan officer and royalties analyst. Originally from Minot, N.D., she previously served as an accountant at Legendary Capital.

Enclave also has hired Travis Golobich as assistant project manager.

A native of Coon Rapids, Minn., and a graduate of North Dakota State University, Golobich joins Enclave with more than seven years of experience in project management. Previously, he served as project manager at Moorhead Electric.

In his role at Enclave, Golobich will assist in collaborating with the construction and design teams, sub- contractors, and clients to ensure timely project delivery within budget.

Essentia Health hires new health provider

FARGO, N.D. Essentia Health welcomes Dr. Olayinka David Ajayi

Dr. Olayinka David Ajayi has joined the Essentia Health team in Fargo, where he specializes in hyperbaric medicine. Hyperbaric oxygen therapy is a noninvasive, painless procedure that uses 100% oxygen in a pressurized chamber to improve the bodys natural healing process, treat carbon monoxide poisoning and other FDA/UHMS approved medical conditions.

Dr. Ajayi received his medical education at the University of Ibadan College of Medicine, Nigeria. He earned his masters degree in public health and completed a residency in public medicine at Emory University Public Health, Atlanta, Ga.

His fellowship in undersea and hyperbaric medicine was completed at Hennepin Healthcare in Minneapolis, Minn. Dr. Ajayi is board certified by the American Board of Medical Specialties in public health and general preventative medicine.

Alerus hires new senior business advisor and senior financial guide

FARGO, N.D. Alerus has welcomed Brad Loween as senior business advisor. In this role, Loween serves as the trusted point of contact for business clients, delivering comprehensive financial advice to help them achieve their financial wellness goals.

Loween works closely with experts across Alerus to serve business clients holistic financial needs and ensure access to the companys full suite of diversified services.

Loween has nearly a decade of experience in the financial industry, with expertise in wealth management and business banking. He holds a bachelors degree in biology from Montana State University and served 21 years in the North Dakota National Guard, including deployments to Afghanistan and Kosovo.

He is a volunteer for the Fargo Moorhead West Fargo Chamber of Commerces Military Affairs committee and the Department of Defenses Employer Support of the Guard and Reserve program. He also serves as a board member for Rebuilding Together of Fargo-Moorhead.

Alerus also has welcomed Isaac Bumgardner as senior financial guide. In this role, Bumgardner is responsible for assisting clients in identifying their specific financial needs and providing comprehensive advice to help them achieve their financial wellness goals.

He works closely with experts across Alerus to ensure each client has access to the companys full suite of diversified services.

Both of the new hires are based at Alerus office at 51 Broadway in Fargo.

Send your promotions and new hire information to aweeks@prairiebusinessmagazine.com.

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Prairie People: New hires and promotions - Grand Forks Herald

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2-year degrees that go on to the most meaningful jobs – Gwinnettdailypost.com

Monday, December 28th, 2020

A third of a lifetime is spent working, making a meaningful career a critical life decision. Having a consequential career is not about monetary gain for many hard-working Americans. On the contrary, it is about making a marked difference in the world. Take, for example, teachers, who shape the minds of future generations. While the entry-level annual salary for teaching is slim compared to other careers, it doesn't stop the thousands who pursue a career in education because they find great purpose in their profession.

Studies also show that those who love their work live longer, which is a priceless consideration when choosing a profession. Balancing out working a meaningful job and making the median full-time wage (around $50,000) can be challenging, but it's possible to live the dream and make a decent living at the same time. Stacker compiled a list of two-year degrees using 2020 data from Payscale on the most meaningful employment. Jobs are ranked by degrees whose graduates report having a high meaning job, with ties broken by highest mid-career pay.

Many of the degree programs and jobs listed are in the health care field, ranging from medical secretarial science to alcohol and drug studies. While some find meaning in providing administrative support, others find daily joy in performing diagnostic tests. All of the jobs listed assist the general public in one way or another, requiring an altruistic attitude.

Money certainly plays a small role in job satisfaction, with seven of the top 10 most meaningful jobs earning mid-career pay above $60,000 per year. Helping others won out over money however, as the top job on the list saw its professionals earn less than $50,000 by the mid-point of their careers.

Continue reading to find out the two-year degrees that go on to the most meaningful jobs.

You may also like: Highest-paying state for 50 different jobs

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Why Data is the Real Value Behind VR – MarketScale

Monday, December 28th, 2020

On Spatial Perspectives, host Dan Cui will have a one-on-one dialog with innovators and thought leaders in the growing Spatial Reality, or Spatial Computing, market. Cui will invite guests who can discuss the real world use cases of the technology and how it could benefit mankind while exploring any drawbacks and how they might be mitigated.

It is an undeniable fact that data affects our everyday lives. While data gets a bad rap in the news when associated with data breaches or privacy concerns, the collecting and analyzing of data can change lives. Stan Karpenko, Co-Founder & CTO at GiveVision knows this first hand. Dan Cui, Host, Spatial Perspectives, sat down with Karpenko to learn more about the true value of data.

GiveVisions goal is to make the lives of visually impaired people better with the help of their products and services. One such asset they provide to those who are visually impaired is a services product thats attached to their glasses that will allow the clinicians to have the ability to actually monitor their patient and provide new treatment regimes for that patient based on what they see happening on a daily basis.

When it comes to data, Karpenko feels it is a vital element of developing products that can help people. I think the data becomes the key part. I think the hardware becomes irrelevant over time, it will become a commodity. The real insights and the real values in the data, Karpenko said. He posed important questions like, can we effectively collect the healthcare data about the patient over a long period of time to make clinical decisions? Can we arrive at a point in time where we dont need the patient to call the doctor when they can feel the symptoms? Can we pick up the symptoms before they can feel them? So the entire sort of changing the career pathway is really what we see as the biggest opportunity facing the AR and VR world. I think, in reality, theres an enormous opportunity for AR and VR companies to develop products that will, just the same as smartwatch, become just a vehicle to collect healthcare data for the benefit of the patient, Karpenko explained.

He believes that those devices will be used for entertainment, or in our case as an enabler for them to do things. But as a byproduct of that, they will be able to watch for patients and inform the doctor when they need to see the patient before its too late. So thinking about preventative medicine if you like, Karpenko said.

For more insight into how data is a key element of progress, listen in to this weeks episode of Spatial Perspectives.

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MK warns of spiritual side effects as vaccination drive continues on Shabbat – The Times of Israel

Monday, December 28th, 2020

Ignoring rabbis objections, and prompting fury from religious politicians, Israel vaccinated thousands of citizens on Shabbat.

The Health Ministry views all-week-long vaccination as key to achieving quick coronavirus protection part of a plan, which also involves 24-hour clinics, to vaccinate more than 150,000 a day.

This past Saturday, the first of the vaccination drive, all four healthcare providers carried on giving shots to the 60-plus public, albeit at significantly reduced capacity, they told The Times of Israel.

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MK Uri Maklev of United Torah Judaism slammed the Health Ministry for encouraging it. How will there be a blessing for the work of their hands, when they harm Shabbat and the [religious] public in such a serious manner? he asked rhetorically in a Haredi newspaper on Sunday.

A woman receives a coronavirus vaccine at a clinic run by the Meuchedet healthcare provider. (courtesy of Meuchedet)

The politician claimed that Health Minister Yuli Edelstein had promised him that there would not be Shabbat vaccinations, and attacked the justification given to administer them.

Edelstein said it was done so that the country can quickly deliver COVID-19 protection, and invoked the Jewish legal principle of saving a life, or pikuah nefesh, which trumps nearly all other religious requirements, including Shabbat. The coronavirus endangers all of us, the vaccines will save all of us, he said.

Hospital workers in protective gear are seen in the coronavirus ward at Ziv Medical Center in the northern city of Safed on October 7, 2020. (David Cohen/Flash90)

But many Orthodox Jews say that pikuah nefeshdoes not normally extend to preventative medicine. They put everything in the category of pikuah nefesh, Maklev said of Health Ministry leaders. We have seen in the past that many of their instructions did not stand up to scrutiny.

There is no prohibition on administering or receiving a vaccine on Shabbat, according to most rabbis, but they say clinics should stay shut because their operation involves other actions considered to desecrate the holy day of rest, like logging patient information on computers and operating other electrical items that are needed. They also express concern that people are made to break the religious rule against driving on Shabbat to make their appointments.

The chief rabbis have refused to back operation of vaccine centers on Shabbat for now. Currently, there is no permission to violate Shabbat for the sake of vaccination, Ashkenazi Chief Rabbi David Lau said on Thursday, according to Orthodox media.

Israels Ashkenazi Chief Rabbi David Lau at the Western Wall, in the Old City of Jerusalem, July 21, 2019. (Noam Revkin Fenton/Flash90)

He stressed that he supports vaccination, but argued that so long as clinics are not operating during every hour of every other day, working on Shabbat is not justified. For now, they should ramp up capacity without working Saturdays, he argued.

If and when clinics are vaccinating 24/6, it will be possible to consider also vaccinations on Shabbat, Lau said.

Even if the chief rabbinate eventually gives its blessing to Shabbat shots, there are indications that some influential ultra-Orthodox rabbis will remain steadfast in their objection to them.

The massively influential ultra-Orthodox halachic authority Rabbi Asher Weiss wrote that the situation is not urgent enough to consider vaccination an act of pikuah nefesh.

Rabbi Asher Weiss. (Gershon Ellinson/Flash90)

He was responding to questions from the UK and the US, so it is possible that he will issue another ruling regarding Israel. If he does not, Shabbat vaccination, even if part of a 24/7 campaign, is likely to remain taboo for a large part of the Israeli Haredi community, including politicians from Maklevs party, who revere the rabbi.

The one proviso in Weisss position was for people in high-risk categories, or who risk infecting people who are high-risk. If they have Shabbat appointments that cannot be moved without incurring delays, in some circumstances, he would allow them to be treated and even driven to the vaccination station in certain cases, though by a non-Jewish person, and not by a Jewish person who, in his estimation, is supposed to be observing Shabbat.

Religious objections are not stopping healthcare providers. A spokeswoman for Maccabi Healthcare Services told The Times of Israel that her nurses vaccinated 7,000 people on Shabbat, some of whom had appointments for next month and were offered to vaccinate earlier if they took Saturday appointments. Opposition from rabbis would not stop them during future weekends, she said.

Meuhedet gave 1,500 injections, mostly in Netanya and Tel Aviv. Leumit gave 2,000, mostly in central Israel. Clalit only operated in the Arab Jerusalem neighborhood of Sheikh Jarrah.

Weiss and Lau both hail from the ultra-Orthodox community. But while religious Zionist rabbis are often thought to take more lenient approaches than their Haredi counterparts, when it comes to this issue, they have not done so.

Rabbi Shlomo Aviner (Yossi Zamir/Flash90)

If they arent working at night, its serious but not urgent, leading religious Zionist Rabbi Shlomo Aviner told The Times of Israel on Sunday, saying no to Shabbat vaccinations. Like Lau, he said that if Israel were providing vaccinations 24/6, the answer might be different.

Aviner, one of the stricter rabbis of religious Zionism, said: The vaccine itself does not involve Shabbat desecration, but the actions around it are, giving examples of logging patient data on computers.

His observation that the injection itself does not transgress Shabbat reflects the laws as they are found in the book, Shemirat Shabbat Kehilchatah, widely viewed as the authoritative Orthodox laymans guide for Sabbath observance.

The Hebrew text from the religious guide, Shemirat Shabbat Kehilchatah, which says that there is no Torah prohibition on taking a regular vaccine on Shabbat. (Zak Jeffay)

Rabbi David Stav, chairman of the moderate Orthodox rabbinic alliance Tzohar, also said he cannot justify Shabbat vaccinations for now, apart from very high risk populations, but added that he hopes this will change.

I urge the government to decide how important it is to keep centers open, and if they are open 24/6, Im almost positive that rabbis would allow vaccination on the seventh day as well.

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Love Island’s Dr Alex George opens up about the hardest year of his life – Devon Live

Monday, December 28th, 2020

Former Exeter University student and Love Island contestant Dr Alex George has opened up about dealing with grief and working though the coronavirus pandemic after the sudden death of his younger brother.

The A&E doctor, from Carmarthenshire, bravely spoke out about coming to terms with his loss in a year which has also seen him work 18-hour days for weeks on end balancing his role as a frontline medic with his role as a public health figure.

On July 24, Alex - who studied medicine at the University of Exeter - shared news of his 19-year-old brother's death in a heartbreaking post on social media.

Llyr, a talented student who was about to start medical school, took his own life.

Now Alex has spoken about his determination to help others with their mental and physical health to try and prevent other families from going through the pain that his family have endured over the last six months.

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Speaking to WalesOnline the 30-year-old said: "Its an up and down journey. I think what is interesting is that my life feels a bit like before and after there is this big line of separation.

"My memories feel very distant but I think thats part of a trauma like this. Grief is an ongoing thing.

"Especially with the pandemic, work, and obviously Im living alone, its not helping unfortunately. Saying youre allowed to bubble with other people is one thing but the reality is you dont see people very much.

"But Ive been able to see my family and I have a really good set of friends so we are getting through it. Its just about taking each day as it comes and trying to do something positive. I bury myself in my work quite a lot which is both a good and bad thing but it does help me in scenarios with things like this.

"[Christmas] will be tough, all of the firsts will be hard and Christmas will be really tough but well get through it. We dont have any other options. I would never wish this on anyone else you just have to accept its happened to you and do what you can with your life."

In the weeks and months after his brother's death Alex has not shied away from talking about a situation that to many people is simply unimaginable.

Speaking to Lorraine Kelly in September the former reality star described how he had been in a restaurant with friends in London when his dad phoned him with the news. In the emotional interview he went on to talk about how he and his brother Elliott had to drive together back to Wales sitting in silence, crying, and shouting in anguish during the unthinkable five-hour journey.

He has also spoken about the trolling he had endured and shared one message that read: "Your brother is dead, get off social media" to which Alex responded: "Imagine being this person. Im holding by a thread and you get people like this."

Despite everything, what Alex is determined to do is pay tribute to a younger brother who he describes as a "mini me" a conscientious, empathetic, and confident teenager and talented footballer who would have doubtlessmade a "very good doctor".

Alex said: " It is hard. At the moment [Llyr's] name is associated with a certain thing and suicide and its very very hard to separate that but we do do our best. Ive got pictures and stuff of him and we do try and laugh about certain things. I saw a meme and I just thought: 'Hed laugh at that' you have got to think about those things.

"I think its important to be open. I would never want to shy away from whats happened. With suicide theres no shame in it. Its the same as if someone has a heart attack its a very sad, preventable cause of death of course but its not something I would ever be ashamed of. Its happened we have to try and do something positive.

"Its hard enough to deal with it anyway but quite frankly in the public eye it's tough but also the amount of support Ive had is unbelievable. There is no doubt, really, people have been so kind I think social media gets a bad rep sometimes, even the media in general, but people have been very kind and supportive and thats helped me a lot."

It's not just online that Alex has received support however. When his mother Jane started knitting to help keep herself busy dozens of people from the Carmarthen community put in orders to buy her products, which will raise money for mental health charities. Then there are those who also volunteered to help, creating an "army of knitters" for the Welsh bank worker.

Alex added: "She started knitting to try and distract herself. She had that feeling of guilt you inevitably get in that scenario, especially as a mother or father. So she sat there and said: 'Ill knit to distract myself' and thought: 'Well, Ill try and sell some of this stuff'.

"Someone actually bought a pair of her gloves and then she thought 'People might buy this' and all of a sudden the orders started coming in.

"My dad is retired, my mum is still working in a bank but obviously is off on long-term leave and its really, really tough. If you sit still too long its not good for you. You need to keep busy its not good for you to not to be active mentally."

When it comes to keeping busy it would be difficult to overemphasise how hard Dr Alex has worked this year. Working in the A&E department of University Hospital Lewisham in south London he and his team have seen first-hand how hard the area has been hit by Covid-19. That's at the same time as the content Alex has been sharing with his combined two million followers on Instagram and YouTube talking about everything from vaccines to health and wellbeing advice.

In his podcast series, the Waiting Room, he and emergency medical consultant Dr Anna Colclough describe facing huge amounts of patients coming in and needing to be intubated both young and old. You can find more about that here.

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Alex, speaking in mid-December, said: "Lewisham was hit so hard and so early that we kind of realised that it was coming. The speed in which it happened and how unwell patients were coming in, it was obvious we had a big problem so there was a real realisation that something terrible was happening.

"Lewisham and south London has been very, very hard-hit. In fact we are going through a very difficult wave at the moment, we are really busy at the moment the hospital is full with a lot of Covid patients.

"Its been tough, its been really tough, but the sense of teamwork we have, weve pulled together, the camaraderie, we really are a team. Weve looked out for each other and supported each other so in many ways its been a reminder that there are other things in the world.

"Its something you look back on now and you think: 'At least I felt I was a part of it, at least I could do something positive'. I do feel that throughout the pandemic in hospital and through using my platform that I have helped people. And I do think I get some comfort from that.

"I love my job, its my passion, and I would feel very lost without it."

Talking about managing the second wave of the pandemic this winter, Alex added: " I gave so much in round one, Ive got to try and preserve a bit of energy the second time. It nearly killed me that first round.

"There were 18-hour days almost I did 22 weeks and I didnt take a single day off. I wasn't necessarily in A&E every day, I was going into A&E four or five days but Id be doing YouTube videos. PHE [Public Health England] were expecting us to do a huge amount of advisory stuff, most people would listen to doctors and not presenters, so the amount of responsibility to create this content was huge. Im a little bit burnt out. "

Despite everything this year has brought Alex is determined to remain positive for the new year ahead. Next year he hopes to transition into GP work as well as his A&E role a move into the preventative medicine he has become passionate about, especially giving advice around mental and physical health.

In May 2021 he will also celebrate the release of his first book Live Well Every Day a book addressing the modern health challenges we face and how little changes to our routines can make a big difference. According to Alex using the principles and advice in his book has helped him deal with his hardest days, from his time as a medical student to the monumental challenges he is now facing.

Explaining the thinking behind his book, he said: "The idea of the book came many years ago when I was at medical school.

"I ended up being on placement somewhere that I was a bit isolated and started feeling not myself. I stopped exercising, I started eating badly, I was sleeping quite badly, I wasnt really seeing friends. I wasnt doing the things that I knew were right for me and my mental health and my own happiness as well.

"I made changes, little changes I started going outside for a walk every day, I started exercising every day, I planned my own meals, healthy meals, I planned bedtimes, I had time off my phone, doing all those good things. I became quite isolated so I made a plan to call someone every night someone different, a friend, a family member, every night and chat with them.

"I found those changes, an accumulation of those changes, meant that I just felt so much happier and healthier and I think thats the premise of this book giving people those tools they can use to make small changes to their own lives that ultimately that will make changes to not just their mental health but physical health too.

"Most of the book I wrote through the pandemic actually. I felt quite inspired and quite driven to write it with everything that happened with my brother.

"The book isnt written for him in that sense but I do feel it was a huge motivating factor. I couldnt help him but maybe this book will help other people and hopefully can protect people from ending up in that scenario.

"He was very proud of it he was really excited about the book. I had written a bit of it and we had actually had the publishing contract and agreement and he was so excited the book was coming to life."

You can pre-order Live Well Every Day from retailers including Amazon, Waterstones, and WHSmith.

Samaritans (116 123) operates a 24-hour service available every day of the year. If you prefer to write down how youre feeling, or if youre worried about being overheard on the phone, you can email Samaritans at jo@samaritans.org.

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Israel Paying Economic Price for 4th Election in 2 Years – The Media Line

Monday, December 28th, 2020

Economic uncertainty and instability are real cost of Israels elections

Elections cost money. And Israels upcoming election, the fourth in two years, will cost much more than previous ones.

The financial burden of the election on state coffers is compounded by the fact that the government has not passed national budgets for 2020 and 2021.

The cost of holding Israels upcoming election, scheduled for March 23, 2021, is estimated at close to 500 million NIS ($155.4 million). This is at least 20% higher than the last elections in March 2020 and higher by as much as 40% than the first election in the last two years that took place in April 2019.

There is a price for everything, and a democracy requires spending money, Giora Pordes, spokesman for Israels Central Election Commission, told The Media Line.

One reason for this cost increase is arrangements needed to hold elections during the coronavirus pandemic. Adding extra voting sites and poll workers, taking precautionary measures and dealing with the unknown are major factors driving up those costs.

The Knesset, Israels parliament, disbanded itself in late-night votes on Monday that stretched into early Tuesday morning, once again sending the country to the polls

But economic uncertainty and instability are the real cost to Israels economy of holding new elections.

Israel is suffering from a lack of governing decisions, with not passing national budgets for 2020 and 2021 among the most major. The economic situation has been made even more difficult during the past year for the country, and the entire world, due to the coronavirus pandemic.

Clearly, under normal conditions, Israel as an advanced economy with 14% unemployment and in a recession due to the pandemic should have a well-functioning government with a well-defined budget and a set of reforms. Unfortunately, we are not there, Leo Leiderman, professor of comparative economics at Tel Aviv University, told The Media Line.

I think clearly that going to the fourth elections in two years is not something to be applauded by anyone. On the other hand, we have to realize that the existing government has not been performing. It is in paralysis in its decision-making processes, said Leiderman, who is the chief economic advisor to Bank Hapoalim, Israels largest commercial bank, and formerly served at the Bank of Israel as head of the research department and a senior director.

There is a price for everything, and a democracy requires spending money

Not having an annual national budget is a major factor in the uncertainty that Israel currently is facing.

On the cusp of the new year, the government is still running itself based on the 2019 budget, alongside certain emergency pandemic- and defense-related allocations. Because of this, government ministries cannot prepare for 2021.

We dont know what to do. We dont know whether to prepare cuts in our budget or not. We are in a period of uncertainty, said a source in one ministry who asked not to be named.

The finance ministry told The Media Line on Wednesday that it will provide instructions to the ministries in the coming days.

Only after the election and the formation of a new government can a budget be planned, passed and implemented.

In perspective, 2021 seems like it will be a very challenging year for the political system and we need to have a budget as early as possible, by mid-year or later, Gil Bufman, chief economist for Bank Leumi, Israels oldest banking corporation, told The Media Line.

Government policies have longer-term impact, especially regarding structural changes in the economy, for instance with tax breaks or with policies directly connected to the countrys social fabric, Bufman said.

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Health care, mental health, social services and education are some of what Bufman termed, soft infrastructure. These are areas that are suffering greatly from a lack of investment by the state, he said.

A budget framework with multi-year elements of planning gives more time for longer projects like hard infrastructure projects, for instance, energy, water and transportation. We already see a lot of these in much deeper progress, such as the Tel Aviv subway system, Bufman explained.

For Bufman, the lack of a budget, and even more so during another election period, is a big challenge. We need structural change. Putting things off from year to year is not healthy, he said.

There is a large degree of inequality of what is in the pipeline. I have a feeling that the soft infrastructure projects will suffer, he said.

If and when we get the coronavirus pandemic under control and the economy starts to recover next year, our economic pace will be much lower than our potential. We could be doing much better with a stable government, infrastructure projects and reform. It is not a catastrophe, but it is a pity, it is too bad

The Alyn Hospital Pediatric & Adolescent Rehabilitation Center says its projects will suffer, too.

There is no preventative medicine. We [the healthcare sector] are dealing with emergencies because of the lack of strategic planning and policies. The government is not looking at long-term health processes, said Dr. Maurit Beeri, Alyn Hospitals director-general.

There is a lack of policy building. The HMOs are looking at things quarterly, short-term instead of long-term. Frankly, they should be investing in these young people, rather than paying far more for services when these children grow older, Beeri told The Media Line.

Yet, even with the pandemic hanging over a new governments policies, Israel is in a comparatively good position relative to other developed economies.

This is a result of the country starting the pandemic in a better position due to the growing high-technology sector and steady population growth, which much of the developed world lacks, Bufman said.

Israel has a good economy, Bufman said. We are in better shape than Spain, France and the UK. We are doing much better, he said.

Leiderman said that Israels good economy could be better if the country was in a good political situation.

If and when we get the coronavirus pandemic under control and the economy starts to recover next year, our economic pace will be much lower than our potential. We could be doing much better with a stable government, infrastructure projects and reform. It is not a catastrophe, but it is a pity, it is too bad, he said.

Still, Leiderman noted, the sooner elections occur, the sooner the political situation can become clarified which can lead to better times.

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Nurses Reflect on Being at the Frontline of the Coronavirus Pandemic – Mpls.St.Paul Magazine

Monday, December 28th, 2020

Editors note:The nurses interviewed in this feature are former recipients of the Mpls.St.Paul Magazine Outstanding Nurses Award. We are grateful for their time and input for this feature.We are in the process of outlining our approach to this annual editorial initiative. Please send an email tooutstandingnurses@mspmag.comto let us know you would like to receive details once we are ready to move forward.

Time is of the essence when you find yourself in an emergency situation.

Just ask Kathleen Koivisto, an in-flight emergency medicine nurse with Life Link III. She doesnt waste any time when the helicopter carrying her and her team lands at the scene of an accident.

She quickly gathers all the needed suppliessuch as airway bags, a ventilator, sometimes an ultrasound, and protective gear to help keep patients safeto prepare or intubate a patient before putting them in the helicopter for the ride of their life to a level-one trauma center. But now with COVID-19, theres an extra, critical step. Before Koivisto can interface with first responders for the handoff of the patient, she must also put on all the necessary high-level personal protective equipment (PPE) to ensure she keeps herself and those around her healthy and safe. We wear masks, gloves, and eye protection with all patients. With suspicion for COVID or COVID-positive patients, we add Tiger masks or N95 and gowns. It all depends on what symptoms the patient presents.

Taking the time to put on the added PPE can be tense when a patient needs immediate attention. If youre watching a monitor and their vital signs are junky . . . it feels long, Koivisto says. A couple minutes is a long time in an emergency. Nobody has suffered because of this vital extra step, except maybe Koivistos nerves.

Not all of her patients are accident victims. Some need transport from rural hospitals to major medical centers for specialized neuro, cardiology, and trauma care. Still, COVID protocols are essential. Patients who dont require a breathing tube but are COVID positive can be transported with a Sea-Long Helmet. This allows us to give them oxygen and support their breathing without exposing the transport staff and others to the virus.

Our pandemic-filled world is testing nursesfrom administrators and educators to those on the frontlines in ways they never could have imagined when this year started. And thats saying a lot, since some of them have been doing their jobs for decades.

We talked to seven nurses who shed light on their lives and their profession during these unprecedented times.

Kristin Lau, a public health nurse in Ramsey County, works with first-time mothers, and an important part of her care strategy is visiting them in their homes. She makes house calls from the time theyre pregnant until their child is 2 years old to ensure everyone stays healthy and progresses as they should. However, since March, shes needed to turn these visits into virtual ones.

Now, instead of hopping into her car and listening to some relaxing music to clear her head between home vis- its, Lau engages with her mamas, as she affectionately refers to them, on Zoom, Microsoft Teams, and Google platforms. A day of several back-to-back virtual visits can leave her feeling extra tired. Theres a study that says it takes a lot more energy to engage over Zoom for one hour than it does in person, Lau says. I think its something like it takes three times the energy.

However, shes thankful to have the technology so she can stay engaged with the women she cares for and get a chance to still see them moving about their lives at home. Lau is always on the lookoutmonitoring her pregnant mamas for any visible signs of distress. For example, one client who was 37 weeks pregnant showed signs of preeclampsia, a life-threatening condition for both mother and baby. As soon as she popped up on my screen I could see her face was quite puffy, Lau recalls. After asking her client a series of questionsAre your hands swollen or tight? Do you have a headache? Hows your visionblurry, seeing spots? Any dizziness?she had the expectant mother check her blood pressure using the cuff thats provided by Ramsey County. Lau

knew this woman had to get medical help right away. She delivered the baby about six hours after she went to the hospital, Lau says.

As a nurse who does home visits, Lau has always had a unique portal into the personal lives of her new mothers, which helps her advise and care for them. And now, with Lau working from home, these new mothers are getting a glimpse into hers. Lau has five childrenages 9 to 20three of whom are doing distance learning at home. Plus, her husband, who has a preexisting health condition, also works from home. So thats five people, plus a couple of pet dogs, jammed into their home. Lau has set up a private room for her meetings, but that doesnt stop her clients from hearing her kids loudly engage with their siblings in another room and her dogs barking at the Amazon truck. I think its almost relatable to them to see me in the mother role, Lau says. It brings them joy.

We think about this cohort of students now in the academic programs. Theyll be the first nurses to be educated about this type of pandemic worldwide. Theyve studied and learned about pandemics in other countries, but its at a distance. Its not us. But now its here, and were living it, and were not doing so well either. Susan OConner-Von, associate professor, University of Minnesota School of Nursing

College campuses, such as St. Catherine University, have also taken to making virtual house callsbut in this instance on students. One evening back in March, Jocelyn Bessette Gorlin, an associate professor of pediatrics in the school of nursing, was teaching an advanced nursing health assessment class. That same night, the school announced it was closing the next day due to COVID-19. In the week or so leading up to the announcement, Gorlin had gotten a jump-start and had connected with the schools IT department to learn how to record Panopto videos, a kind used in the field of education, just in case the school transitioned to e-learning. We asked ourselves: How can we teach hands-on assessment skills remotely? she says.

After class that March evening, Gorlin, along with other faculty members and teaching assistants, formed an assembly line and filled Ziploc bags with the tools that the graduate students would need to practice their skills at home (tongue depressors, reflex hammers, pen lights, and more). When a ship is having trouble, you get on this raft and you do what you have to do, Gorlin says.

As it turns out, they learned they could do quite a lot. Within one week, students recorded their first video demonstrating health assessment skills on people with whom they were quarantined, such as their children, parents, and roommates. (One student who lived alone formed a mannequin out of old clothes that she beautifully assessed, Gorlin says.) Gorlin witnessed her students listening to their childrens heartbeats and gently assessing parents abdomens. The recorded videos gave us a glimpse into their home lives, she says.

Gorlin also used Google Meet and Sammy, a 140-pound medical mannequin from the school of nursing that wound up lying on her dining room table, to interface with students and offer feedback on how they could improve their assessment of a patient. Google Meet also came in handy when she held virtual lab sessions three times a week from her home. Gorlin enjoyed demonstrating how to do cranial nerve and musculoskeletal assessments on her roommateher husband, a hematologistwhod sometimes provide comic relief by swing dancing instead of sitting quietly for his checkup.

In the fall, Gorlins students returned to campus for classes on a part-time basis. While Panopto videos and Google Meet were part of the syllabus, so were small face-to-face lab classes that alternated with synchronous virtual sessions connected via technology and teamwork. At the start of class, students get their temperature taken and don gloves, masks, and face shields before meet- ing up with their assigned partner, whos wearing a plastic three-by-four-inch name tag with their picture on itas all of the PPE makes the faculty and students unrecognizable.

The teamwork Gorlin witnesses, along with the use of technology, seems a little NASA-like to her, as students depend on each other to maintain health and safety while also promoting new state-of-the-art technology that will benefit people and health care. Were in different spaces, we have high-tech technology, and were connecting remotely. Even though its estimated that this sort of hybrid teaching model takes educators about one and a half times longer to prepare and to teach, its worth it. Were preparing them to be on the frontlines, Gorlin says. So were on the frontlines to put them on the frontlines.

As of press time, in Minnesota alone, 157,096 people have tested positive for COVID-19, and 15,022 have been health care workers.* Given the state of the world, some educators thought that enrollment in nursing programs would decrease. However, enrollment in the nursing program at the University of Minnesota School of Nursing has remained steady and increased in some cases. Ive always been impressed with students, but especially now with their deep desire to become nurses in the midst of a pandemic, says Susan OConner-Von, a full-time faculty member at the University of Minnesota School of Nursing, whos been in the profession for more than 40 years. I think we were nervous. Will anyone come back, you know? Who would want to become a nurse during this time? Im just so impressed with their motivation, with their dedication, with their desire to help others.

OConner-Von and her colleagues have discussed the unanticipated experience nursing students are having right now. We think about this cohort of students now in the academic programs. Theyll be the first nurses to be educated about this type of pandemic worldwide, she says. Theyve studied and learned about pandemics in other countries, but its at a distance. Its not us. But now its here, and were living it, and were not doing so well either. This cohort of students are going to be so uniquely prepared because they have the lived experience.

During the early months of the pandemic and the social unrest that soon followed, when many of Gorlins students expressed their concerns about what was happening all around them, she set aside time when they could connect with her one-on-one. Id say 80 percent of our conversation focused on them questioning what was right in their career going forward and how they were going to do it, she recalls. Her advice? What I kept saying to the students was, This is not the journey you expected. But youre still marching forward. Youregoing to have a different step, and youre going to have a different pace to the march, but youre still moving forward, and youre going to be more resilient because of it.

My hope is that people will recognize how devastating underlying conditions can be. A silver lining to this pandemic would be if this changed peoples perspectives on health and they made lifestyle choices that improved quality of life and improved resistance to disease. Kathleen Koivisto, in-flight emergency medicine nurse with Life Link III

Michelle Curley is the director of nursing for home health agency and infusion nursing at Pediatric Home Service, and she sees this kind of resilience and desire to help firsthand. In her area of speciality, nurses travel to families homes to administer IV therapy to children. However, because these patients are especially susceptible to illness, nurses need to be extremely careful. So when a nurse has even one symptom from the CDCs long list of potential COVID-19 symptoms and has to be quarantined until tested, another nurse will readily step in to avoid having to send the vulnerable child to an infusion center. So far, eight nurses (out of 14 nurses on the team) have had to quarantinethankfully, none of them have tested positive for the virus. Two have gone on maternity leaves during this time. This can make things extra challenging. People have hardly taken PTO because everybody is trying to cover for everybody, Curley says.

There are some treatments, such as intravenous nutrition, that nurses can teach parents to administer to their children without having to leave the safety of their homes to learn how to do it. Pre-pandemic, parents and caregivers would travel to the hospital for up to three days of instruction. After hospitals went on lockdown, nurses traveled to clients homes to teach families. Now one nurse is fully dedicated to doing this training for some treatments virtually.

Of course, young patients love to see their nurses familiar faceespecially in the comfort of their home. However, these days, it can be hard to see that friendly face when its covered in PPE. To put their young patients at ease, and to get some giggles, nurses get creative and will draw eyelashes and lips on their protective goggles and face shields.

Due to a shortage of face shields during the first month of the pandemic, Curley and her crew made some from plastic, foam, and Velcro. Today theres enough PPE for all her nursing staff, and Curley wants it to stay that way. To help manage its supply, Curleys office puts it on lockdown, allowing nurses to grab only what they think theyll need over a set amount of days.

During these past nine months, the nursing profession has proven it can pivot with how nurses deliver care to patients. And they do so remarkably well. Mari Holt, vice president of clinical operations at Allina Health Mercy Hospital-Unity Campus, says one of the biggest challenges nurses continue to face is the vital yet complex layering on of head-to-toe PPE protection when engaging with COVID-positive patients or patientswhose COVID-19 status is under investigation.

This isnt Holts first experience with a health crisis that required such a high level of protection for staff, however. Back in 2014, when the Ebola crisis hit, she was part of a front-line team that not only helped Unity pre- pare for patients but also worked with three patients who may have been impacted by the virus. But Coronavirus is far different, she says. As a facility that received patients under investigation for Ebolathat was on one unit, she says. The PPE was similar but it was one person on one unit, not 18 patients on the same unit requiring multiple staff to care and be gowned up each and every day throughout the entire shift.

The Unity Campus has different wings and depending on patient volumes, it can have patients under investigation in one wing and COVID-positive patients in another clearly delineated zone. While working in a COVID zone allows nurses to go from room to room and conserve PPE, as all of the patients on that unit are positive, Holt notes, the challenge for the nursing staff is being in the equipment all of their shift. With Ebola, staff would come out of the room and be able to remove their PPE.

When asked how her teams are managing the stress, Holt notes the emotional challenges that accompany being a frontline care worker are very real. Nurses man- aging patients in isolation help anxious families juggle care strategies and telehealth-type visits. Even at a time when patients can have compassionate care visitors, she says, many family members do not want to come and visit their loved one if they have COVID. At times, she notes, nurses are the only person holding the patients hand and spending time with the patient as they take their last breath.

Nurses as a whole also experience an insiders perspective of the health disparities among underserved populations. This fact takes a toll on nurses emotionally. Lisa Sundberg, a nurse care manager who cares for home- less vets at the VA Community Resource and Referral Center in downtown Minneapolis, sees firsthand how the pandemic has affected the homeless population. According to Sundberg, some veterans deal with feelings of isolation alreadyfeelings of being cut off from other people, a loss of relationships, employment, and financial security. Homelessness increases the stress.

When the pandemic reached Minneapolis, many of these vets, some of whom have mental health illnesses, feared for their lives. The veterans were scared to death, Sundberg says. My heart went out to them. They have nothing. Theyre like, At least people have a home to go to and isolate.

Thankfully, the center is a safe haven for those in the community offering medical triage daily for trauma and medical illness, vaccines, COVID tests, and primary care for nearly 300 veterans. Its also a place for thosein need of a warm shower, a place to do their laundry, or a bagged lunch. The staff preaches the importance of handwashing and social distancing. They provide masks for their clients, but many are already wearing one when they enter the building. Also, the center helps these folks connect to other social services nearby, such as homeless shelters like Exodus, Salvation Army Harbor Lights, and House of Charities. Recently, a homeless vet who spent time with an asymptomatic friend who tested positive for coronavirus isolated himself for 14 days in his own room at one of the shelters.

Nurses are so dedicated to their patients, OConner-Von says. They have this strong sense of duty. Back when I worked in ICUs, we would have times where wed be really busy for a week or two. Wed be working double shifts, working all weekend, picking up extra time. But then after several weeks or a month wed get a reprieve. And you could maybe take that day off. This has been going nonstop since March. And so that feeling of exhaustion must be overwhelming. Not only for the patients and families but for the health care professionals.

I think about those administrators trying to support their staff and somehow do self-care and provide emotional support in whatever way they can.

Being the natural caregivers that they are, nurses often want to extend their hand to everyoneincluding their loved oneswho may be struggling. But it can be difficult to do so when theyre stretched so thin. Oftentimes this results in feelings of guilt and putting themselves on the backburner. OConner-Von uses these insights and examples to teach her nursing students that caring for themselves is also part of the job. She gives extra credit to those who take the dog for a run, read a book they dont have to underline, or call a close family member or friend just to catch up so self care becomes a habit. You cant go in burned out and provide compassionate care, she says.

Nurses try to remain hopeful and optimistic about the future. However, many are wondering how people will fare this winter, when the flu is added to the mix. Were all a little on edge, Sundberg says.

In addition, the sheer magnitude of trying to drive home the seriousness of this disease can feel overwhelming at times. Lau educates her families about the signsand symptoms of Coronavirus and where they can get a free test. Im in public health so were trying to keep our public healthy, Lau says. So it feels like a big responsibility.

She tries not to allow the heaviness she feels at times to overwhelm her. Though she admits its easy at times to get tied up in ... your own chest and in your own stress. Thats when she reminds herself that things are going to be OK and puts something on the calendar that she can look forward to, even if its just a Friday night date at Costco with her husband.

Lau says the number-one lesson they taught in nursing school was the importance of being adaptable and flexible. Never has that proven more true than it has in 2020, a year that we will never forget. Lau likens her role to being a wartime nurse. The battlefield has changed, she says. Our battlefield is our community, our grocery store, our hospitals, our schools. Were all trying to combat this [disease] and were all in this together.

As with any warfare, tactics evolve to ensure peoples safety and care. We are all adapting to be flexible, Holt says. Communication is key as things have changed, and continue to change, as we learn more about the disease. It is challenging to keep up with the changes, which is imperative for our bedside staff.

The CDC reports those with certain underlying medical conditions have a greater chance of becoming severely ill from COVID-19. Of course, not all underlying medical conditions are manageable. However, Koivisto believes that if people become more cognizant in caring for their overall health it would give them a better chance of combatting health setbacks. My hope is that people will recognize how devastating underly- ing conditions can be, she says. Many of these can be lessened with lifestyle changes like clean eating and exercise. A silver lining to this pandemic would be if this changed peoples perspectives on health and they made lifestyle choices that improved quality of life and improved resistance to disease. It would be amazing to see more Americans use food and exercise as preventative medicine to help decrease the impact of diseases like COVID and others.

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JoAnn and Bob Glick donating $42 million to MetroHealth System, largest gift in its history, to help underser – cleveland.com

Friday, December 4th, 2020

CLEVELAND, Ohio Northeast Ohio natives JoAnn and Bob Glick have pledged $42 million to MetroHealth System, the largest gift in the hospital systems 183-year history.

The couple chose MetroHealth to receive the gift because of the hospital systems commitment to community health and its goal of reducing health disparities, passions that the Glicks share. The gift was announced today.

The gift enables MetroHealth to address social determinants of health so that everyone has equal access to health care and preventative medicine, especially underserved women and children.

We hope that zip codes dont matter anymore, said JoAnn Glick, who trained as a registered nurse with an emphasis on community health.

In recognition of the gift, MetroHealths new main hospital, now under construction on West 25th Street, will be named the MetroHealth Glick Center. The 11-floor hospital is part of the health systems $946 million campus transformation project, which is designed to spur development in the surrounding neighborhood.

However, the $42 million gift will not be used for hospital construction.

It will be wonderful to have our name on the building, said Bob Glick, founder and former CEO of Dots womens fashion company. But whats really important is what happens inside and throughout the neighborhood.

Clearly, the amount of money is huge and will help us focus on our efforts to ensure Cleveland is a healthier place, MetroHealth president and CEO Dr. Akram Boutros said. Beyond that, the due diligence and inquisitiveness that Bob and JoAnn showed is a huge boost in the arm. It gives us confidence that what we do resonates with individuals who want to see change.

The Glicks want to see their gift used to improve the lives of Clevelanders, Boutros said.

They are so committed to making a difference to folks who dont have access to health care and the interventions needed to live their best lives, Boutros said.

The pledge will be split into two funds:

Choosing MetroHealth

A 2013 Plain Dealer profile that described how Boutros was changing the hospital systems culture as the new CEO caught the couples interest and introduced them to MetroHealths mission.

They were intrigued that Boutros wanted to emphasize keeping people healthy rather than simply treating illness. As they weighed options for philanthropy and researched the hospital system, they were impressed by the passion, caring and engagement of everyone from the maintenance staff to physicians.

They wake up every day wanting to serve the people of Cleveland, Bob Glick said. There is a culture of over-the-top passion for their patients thats hard to describe. That made a difference to us.

This isnt the first substantial gift that the Glicks have given to the hospital system. In 2019, the couple gave $500,000 for programs that help children overcome trauma through the arts, and evaluate children for autism spectrum disorders.

They began The JoAnn and Robert Glick Family Fund of the Cleveland Foundation in 2007.

The Glicks have deep roots in Northeast Ohio. Bob was born in Shaker Heights and earned degrees from Ohio University and the University of Michigan.

In 2011, after 36 years as founder, CEO and chairman of Dots, Bob Glick sold the company to a private equity firm. Dots operated more than 400 stores in 28 states, including Ohio. All stores were closed in 2019.

JoAnn Glick grew up in Youngstown and received a nursing degree from the University of Michigans School of Nursing. She moved to Cleveland in 1976 to attend nursing school and work at University Hospitals.

Bob Glick hopes that the couples gift will inspire wealthy Clevelanders to consider giving to the citys nonprofits. For their part, the couple plans to continue backing MetroHealth.

This is not a one-time gift, Bob Glick said. We want to keep coming back and supporting Metro.

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Global Roundup: Ipsen Wins Fast Track Designation for Cancer Drug and More | BioSpace – BioSpace

Friday, December 4th, 2020

Paris-based Ipsen secured Fast Track designation from the U.S. Food and Drug Administration (FDA) for Onivyde (irinotecan liposome injection) for study patients with small cell lung cancer (SCLC) who progressed following a first-line platinum-based regimen. Onivyde, in combination with fluorouracil and leucovorin, was previously approved for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.

The designation marks the second Onivyde secured in the past six months. In June, the FDA awarded the designation to Onivyde for patients with previously untreated, unresectable, locally advanced and metastatic pancreatic ductal adenocarcinoma.

Ipsen is conducting an ongoing Phase III study assessing Onivyde as a monotherapy for SCLC study patients who have progressed on or after a first-line platinum-based regimen.

Howard Mayer, Ipsens head of research and development, called the Fast Track designation for Onivyde an extension of Ipsens focus and contribution to the oncology landscape.

With this aggressive and often late-stage diagnosed form of lung cancer, we are proud to be one step closer to making another treatment option available to patients, Mayer said in a statement.

Lung cancer is the second most common cancer in the United States. In 2020, the American Cancer Society estimates there to be about 228,280 new cases of lung cancer in the country.SCLC comprises 10% to 15% of all lung cancers and is a very aggressive form of cancer with about 70% of people having metastatic disease when they are diagnosed.

Elsewhere around the globe:

RevoluGen U.K.-based RevoluGen announced new results from its improved Fire Monkey/Fire Flower version 8 (FMv8) protocol. Results show the protocol demonstrated a 30Gb+ yield of long DNA reads raw data of anE. Colibacterial sample on a single Oxford Nanopore Technologies (ONT) MinION flow cell. The increased yield offers significant potential cost and performance advantages across all sequencing platforms, the company said. The FMv8 protocol introduces a needle-aspirate-based, cell-resuspension step prior to cell lysis that boosts DNA recovery. The spin-column has been optimized to deliver homogenous High Molecular Weight DNA extracted and purified from bacterial and mammalian samples. ForE. Coli, the FMv8 protocol allows the ONT MinION to deliver optimal sequencing throughput at an impressive N50 of 36.7Kb, the company added.

GENFIT Frances GENFIT announced the conclusion of the partial buyback of GENFITs 6,081,081 convertible bonds maturing in October 2022. The company said it achieved satisfactory results. Once the buyback is complete, the company will announce the final results.

Abivax Also based in France, Abivax completed recruitment for its Phase IIb induction study for ABX464 as a treatment of patients with moderate-to-severe ulcerative colitis. Top-line results of the PhaseIIbUC induction study are expected to be available in Q2 2021. The Phase IIb induction study in patients with moderate-to-severe UC, enrolled the first patient in August 2019. In addition, Abivax initiated a companion long-term open-label maintenance study in which patients who have completed the induction study were eligible to continue the treatment to further investigate the long-term safety and efficacy profile of ABX464. Previously, the company announced positive results of the previous Phase IIa induction study in UC in September 2018.

HZI Germanys Helmholtz Centre for Infection Research (HZI) secured two awards worth up to $15 million from CARB-X to develop non-traditional approaches against antibiotic-resistant pathogens. The goal is to develop a first-in-class treatment for Staphylococcusaureusinfections and thereby prevent exacerbation of pneumonia. The drug is a small-molecule inhibitor of theS. aureus-hemolysin,a virulence factor responsible for thebacteriums pathogenicity and ability to cause infection and disease. The drug would disarm the pathogens most importanttoxin that causes damage to lung tissue and immune cells. Additionally, HZI is looking to develop a new treatment for difficult-to-treatPseudomonas aeruginosainfections in cystic fibrosis patients. The new pathoblocker treatment aims to disarm pathogens and suppress the disease-causing properties ofP. aeruginosabacteria, instead of killing the bacteria as an antibiotic would aim to do.By rendering the pathogens harmless instead of killing them, selection pressure on the pathogens is relieved and resistance is likely to develop more slowly.

ERS Genomics Irelands ERS Genomics Limited, and Germanys Vivlion GmbH, announced a non-exclusive license agreement granting Vivlionaccess to ERS Genomics CRISPR/Cas9 patent portfolio, to enhance Vivlions gene editing reagents and screening services. Vivlion holds an exclusive license to Goethe University of Frankfurts proprietary 3Cs technology for the production of next generation 3Cs CRISPR/Cas gRNA libraries. The license from ERS Genomics now enables Vivlion to offer both R&D reagents and screening services to its customers worldwide. Financial details of the agreement were not disclosed.

Noema Pharma Swiss startup Noema Pharma secured $59 million in a Series A funding round, as well as four neurological product candidates from Roche. The product candidates will be developed in neurological indications with severe unmet need, such as seizures in tuberous sclerosis complex (TSC), trigeminal neuralgia, Tourette syndrome and other rare neurological disorders.

TSK Laboratory Netherlands-based TSK developed a new needle that could save 4% to 8% of vaccine doses, which could prevent wasted parts of the COVID-19 preventative medicines. A conventional needle has an average dead space of 45 microliters, which is the amount of vaccine or medicine being wasted per injection. TSK Laboratory developed an inventive and patented needle in 2014 in which this average dead space is reduced to 14 microliters. TSK said its Low Dead Space technology prevents waste of liquid vaccine when it is being extracted from the container, which will ultimately stretch the number of available doses.

Horizon Discovery Group U.K.-based Horizon Discovery Group granted a license to Chinas Sanyou Biopharmaceuticals Co. for its cGMP-compliant CHOSOURCE platform. Sanyou will use Horizons gene-edited Glutamine Synthetase (GS) knockoutChinese Hamster Ovary(CHO) K1 cell line for the developmentof pre-clinical antibody drug projects andto support the clinical development and commercialization of its customers human biotherapeutic products as well as offering the platform through its contract research services.

eTheRNA Belgium-based eTheRNA immunotherapies NV entered into a strategic agreement with China Grand Pharmaceutical & Healthcare Holdings Ltd. to establish a new joint venture company, Nanjing AuroRNA Biotech Co., Ltd. in Mainland China. The new company will deploy eTheRNAs proprietary mRNA technology for pharmaceutical research and development and production in the Greater China Region. This follows an undisclosed equity investment by China Grand Pharma in eTheRNAs Series B financing round earlier in 2020. The formation of AuroRNA Biotech with China Grand Pharma provides eTheRNA access to the Greater China market for selected mRNA cancer and infectious disease vaccine programs, its proprietary mRNA formulation technologies and GMP manufacturing process technology. eTheRNAs global programs will benefit from China Grand Pharmas development, clinical and marketing input.

4D Biomaterials Innovate UK awarded 4D Biomaterials, a spinout by University of Birmingham Enterprise and Warwick Innovations, to develop new commercialization of a new class of liquid resins that can be custom-printed into bioresorbable 3D tissue scaffolds providing accelerated and improved wound healing following major surgery.

Tubulis Germanys Tubulis formed a strategic collaboration with WuXi STA and WuXi Biologics to manufacture and advance Tubulis next generation antibody-drug conjugates (ADCs) towards IND-enabling studies. Tubulis has developed a dual platform approach to generate uniquely matched and disease-specific ADCs that combine selective antibodies with effective payloads. Tubulisrecently completed a 10.7 million Series A to expand the therapeutic potential of ADCs and to advance itsuniquely versatile and customizable ADC technology portfolio. The company utilizes two proprietary technologies to tacklelimitations of currently approved ADCs, which includestability and payload-driven toxicity.

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Smelly armpits: Causes, treatment, prevention, and when to seek help – Medical News Today

Friday, December 4th, 2020

Many people experience smelly armpits from time to time. When people sweat, the liquid mixes with the bacteria on the skin. When this dries, it can cause an unpleasant smell.

Several remedies are available for excessive sweating, including over-the-counter treatments, prescription medications, injections, and more.

In this article, we look at what causes smelly armpits, how to treat them, and when it might be a good idea to speak with a doctor.

Sweat is responsible for smelly armpits. Sweating is a normal and necessary bodily function that stops people from overheating.

There are 24 million sweat glands on the body. Most of these are eccrine sweat glands, and the others are apocrine sweat glands. People have lots of both types of sweat gland in the armpits.

When a person exercises or becomes too hot, the sweat glands release sweat, which evaporates and cools the body down. Stress and intense emotions can also make people sweat.

Eccrine glands release a clear liquid that does not smell. However, if it dries on the skin, it can smell.

Apocrine glands release a thick fluid that smells when it mixes with the bacteria on the skin.

The sweat glands become more active in both males and females during puberty. As a result, it is common for teenagers to start to get smelly armpits when they did not before.

Some people have a medical disorder that makes them sweat more than they should. The name for this condition is hyperhidrosis.

Hyperhidrosis affects about 3% of the population. People who have the disorder have overactive sweat glands that release sweat even when they are not hot or exercising.

Hyperhidrosis is usually harmless, but it is sometimes the result of an overactive thyroid.

When sweat mixes with bacteria, it can lead to a distinctive body odor, which people commonly refer to as B.O. If this odor becomes chronic, doctors call it bromhidrosis.

Some foods, such as garlic, can change the way sweat smells.

Good hygiene can help prevent smelly armpits by getting rid of the bacteria that cause the odor.

People should shower or bathe once a day and after exercise. They should also wear clean clothes every day and change their clothes after exercising.

As well as practicing good hygiene, people can try other ways to combat smelly armpits. These include:

Shaving the armpits and using a deodorant or antiperspirant can often help prevent body odor. Regular deodorant comes with a fragrance that will help mask the smell.

Antiperspirant contains chemicals that stop people from sweating. They plug the sweat glands, which tells the body to stop making sweat.

These simple measures might not work for people with hyperhidrosis.

If sweating is excessive, it can cause smelly armpits even if a person washes regularly and uses deodorant or antiperspirant.

The first thing that a doctor will recommend is usually a prescription strength antiperspirant. Sometimes, these might burn or irritate the skin. If this happens, the person should tell their doctor.

If prescription strength antiperspirants do not stop the excessive sweating, doctors might suggest the treatments below.

People usually refer to botulinum toxin injections as Botox.

Sometimes, doctors inject tiny amounts of Botox into the armpits to treat excessive sweating.

Botox injections help stop excessive sweating by blocking a chemical in the body that stimulates the sweat glands.

For most people, it takes 45 days to work, and the effects usually last for about 46 months.

Some people might find the injections painful.

If excessive sweating affects the whole body, doctors might suggest using anticholinergic medicines.

Anticholinergic medicines stop people from sweating, so they are not generally suitable for athletes or people who live in hot climates.

Common side effects of these drugs include:

Eating some foods, including garlic and onion, can make sweat smell different. Alcohol can also have this effect. Consuming certain foods and drinks may, therefore, lead to a sudden change in body odor around the armpits.

Stress and anxiety can make people sweat more than usual. Sometimes, this can lead to a sudden change in the way the armpits smell.

Many different factors can cause what doctors call secondary hyperhidrosis. This term means that the excessive sweating is a symptom of something else.

Possible causes of secondary hyperhidrosis include:

Excessive sweating is not necessarily the cause of all sudden changes in armpit odor.

For instance, the skin condition intertrigo might cause a musty smell. This condition, which causes a rash, develops in folds of the skin, such as those in the belly, under the breasts, and in the armpits.

Doctors might recommend using a special soap that contains 1% ketoconazole. They will also suggest keeping the affected area as clean and dry as possible.

Everyone will have smelly armpits from time to time. It is perfectly normal and not typically a cause for concern.

If smelly armpits are a more frequent occurrence, though, they can get in the way of everyday life.

Both hyperhidrosis and bromhidrosis can cause distress and social problems. When this is the case, the person should speak to a doctor.

The best way to prevent smelly armpits is to wash daily and after sweating.

Using antiperspirant or deodorant and shaving the armpits can also help.

Avoiding alcohol and certain foods, such as onions and garlic, will also help prevent smelly armpits in some cases.

Sweating is an essential bodily function and is perfectly normal. When the liquid dries, it can smell. Most people will have smelly armpits at times.

Washing daily and after exercising, wearing clean clothes every day, and using antiperspirant or deodorant should usually prevent the problem.

Some people have a condition that makes them sweat too much. Doctors call this hyperhidrosis, and it can sometimes lead to body odor.

Various factors can cause a sudden change in armpit odor. These include certain foods and medications.

Anyone who finds that smelly armpits are affecting their quality of life should speak with a doctor.

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Chinese-authored reference book, COVID-19: The Essentials of Prevention and Treatment, now available worldwide in English – PRNewswire

Friday, December 4th, 2020

Originally published in Chinese by Shanghai Jiao Tong University Press, Elsevier secured the rights to publish this important reference book in English at a time when knowledge sharing on preventing the spread of and treating patients infected with the novel coronavirus, subsequently named SARS-CoV-2, was at its most critical.

The three Co-Editors-in-Chief, Jie-Ming QU, Bin CAO and Rong-Chang CHEN, are senior physicians, as well as clinical and scientific research experts specializing in pulmonary diseases and critical care medicine with relevant experience in Wuhan, China, where the outbreak was first identified in December 2019.

Along with other physicians working in China, the Co-Editors-in-Chief have built up deep knowledge and insights on the prevention, control, diagnosis and treatment of the disease, all of which are now globally relevant to managing the COVID-19 pandemic.

COVID-19: The Essentials of Prevention and Treatmentelaborates on the ethology, pathogenesis epidemiology, clinical characteristics, treatment principles, rehabilitation and prevention, as well as prevention and control measures for COVID-19 to provide healthcare workers first-hand information on the prevention, control, diagnosis and treatment of COVID-19.

Key features of the book include:

Quotes

Nanshan ZHONG, Peer Reviewer Academician of Chinese Academy of Engineering Director of National Clinical Research Center for Respiratory Disease (The First Affiliated Hospital of Guangzhou Medical University)

"We've entered a normalization phase in the prevention and control of COVID-19, and I believe the insights contained in this book on emergent diseases especially those on acute respiratory infections that have significant socio-economic impact are extremely informative and highly valuable in the prevention and control of future outbreaks. COVID-19: The Essentials of Prevention and Treatmentis the English version of Elsevier's first Chinese-authored publication on the topic of the novel coronavirus. I sincerely hope this book can facilitate better and effective prevention and control of the disease through the sharing of knowledge and experience of Chinese healthcare workers."

Chen WANG, Peer ReviewerPresident, Chinese Academy of Medical Sciences and Peking Union Medical CollegeVice President & Academician of Chinese Academy of EngineeringDirector, National Respiratory Clinical Research Center, Leader, National Key Disciplines for Respiratory MedicineVice-Chairperson, Global Alliance Against Chronic Respiratory Diseases

"The English version of COVID-19: The Essentials of Prevention and Treatment is of considerable significance as it provides valuable insights of the experiences of China's healthcare professionals in their combat against COVID-19 in the country where the virus was first identified. As a new and previously unknown virus, the manner in which it mutates and changes means that the virus will manifest itself differently at different time periods, as well as in different geography, demographic and ethnicities. The book offers an important medical reference of the COVID-19 situation at a point in time in China and highlights the interdependency between Chinese and international publishers in facilitating knowledge exchange to address important global issues."

Jie-Ming QU, Co-Editor-in-Chief Professor and Party Chief of Ruijin Hospital Chair of Chinese Thoracic Society

"The essence of this book is founded upon the first-hand account and experience of health care experts working on the front lines in the areas of prevention and control when the novel coronavirus first appeared, which the authors have systematically and meticulously curated to form the framework of the syllabus. This book is an important reference that brings together some of China's finest experts in respiratory and critical care medicine, as well as showcases the country's expertise in clinical research and professionalism in caring for the infirm."

Tiandong QIAN, Chairman of Shanghai Jiao Tong University Press

"The outcome of this collaboration between Elsevier and Shanghai Jiao Tong University Press is significant and its inherent value is of considerable relevance to the international health and science community. We've also signed licensing agreements for Russian, Japanese, Thai, Malaysian and Vietnamese rights to the book, which demonstrates its global impact."

Dr. Glyn Jones, Publisher, Elsevier

"The book proposal from Shanghai Jiao Tong University Press came at a very important time when doctors and nurses in Europe and the US were having to treat patients with coronavirus for the very first time, and were very interested to learn from China's experience, which it had built up in the months before. Recognizing the importance of the book, Elsevier undertook to ensure publication as soon as possible. Elsevier is committed to publishing high-quality content that will be of interest to researchers. So far this year, we have commissioned 17 new books written by researchers from all over the world related to various, different aspects of Covid-19."

Lynn LI, Managing Director Greater China, Elsevier

"Elsevier supports scientific and medical advancement for the benefit of our society. Publishing the English version of COVID-19: The Essentials of Prevention and Treatmentin partnership with Shanghai Jiao Tong University Press is a way for us to facilitate the urgent global effort to understand, contain and eradicate the novel coronavirus. We believe that clear, consistent and evidence-based guidance and resources are crucial to helping communities overcome the pandemic. This book has undergone a rigorous peer-review process and draws on the rich experiences to present a first-hand account of frontline health care professionals combatting the virus over the course of two months."

Elsevier Novel Coronavirus Information Center

Elsevier'sNovel Coronavirus Information Centerprovides expert-curated information for researchers, healthcare professionals and public health officials, including clinical guidance and a portal to access all of Elsevier's COVID-19 research. All resources are freely available. We also have dedicated hubs for healthcare professionals; health educators and students; librarians; and R&D professionals. You can find these in ourCoronavirus Resource Directory.

About Elsevier

As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems.

In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders.

Elsevier employs 8,100 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on our 2,500+ digitized journals, including The Lancet and Cell; our 40,000 eBook titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world.

Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. http://www.elsevier.com

Media contact Jason Chan, DirectorElsevier Communications, APAC+65 6349 02 40 [emailprotected]

SOURCE Elsevier

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5 Things That Happen When You Don’t Get Enough Sleep – Prevention.com

Friday, December 4th, 2020

Even before the pandemic, more than a third of Americans werent getting the recommended seven plus hours of nightly sleep that industry professionals recommend. Add the stress of everyones new reality, and, by certain estimates, 68% of Americans say they just arent getting enough rest.

While youre probably aware of some of the issues, like mental fog, that can arise when you don't get enough rest, you may not be aware that your snoozing habits may impact all sorts of unexpected thingsthink: how well your heart pumps blood, and even your sex drive.

Most of the systems in our body are predicated on some process of renewal or need for sleep, explains board-certified sleep medicine researcher W. Christopher Winter, MD, the author of The Sleep Solution: Why Your Sleep Is Broken and How to Fix It. Sleep is a fundamental aspect of our thinking, our ability to function, and our immune system. It impacts pretty much everything we need to survive.

So turn off your phone, close the shades, and hop into bed early tonight. If you dont, heres how a lack of sleep may impact your body.

Theres a very strong link between sleep and the immune system in general, says Michael Awad, MD, chief of sleep surgery at Northwestern Medicine and chief medical officer of Peak Sleep. The body repairs just about every cell in the body when it comes to sleep. Sleep deprivation lowers the bodys ability to mount an immune response.

Sleep loss is linked to a higher risk of infection, according to the Centers for Disease Control and Prevention (CDC). One study published in JAMA found that restricting a persons sleep for four hours a night for six days, followed by sleeping 12 hours a night for seven days, can lead to a greater than 50% decrease in the production of antibodies to a flu vaccine. Basically, your body just cant mount the usual immune response when youre wiped out.

Lack of sleep can also lower your immune systems ability to fight tumor cells and lead to the generation of inflammatory cytokines. These proteins are secreted by the immune system and can cause the development of metabolic and cardiovascular disorders.

nadia_bormotovaGetty Images

One study of nearly 117,000 people published in the European Heart Journal found that people who slept less than six hours a night were at a greater risk of developing heart disease than their well-rested counterparts. And getting irregular sleepthat is, having no consistent bedtime and wake timecan raise your risk of having some kind of cardiovascular event, including stroke, congestive heart failure, and coronary heart disease, according to a study published in the Journal of the American College of Cardiology.

There are a tremendous number of mechanisms at play here, Dr. Winter says. When you are sleep deprived or have fragmented sleep, your blood vessels lose, to some extent, the ability to expand and contract to regulate things, he says. People also tend to be at a higher risk of developing high blood pressure when they dont get enough sleep, Winter says, which can be tough on your heart.

Sleep deprivation can also increase cholesterol levels and general inflammation throughout your body, leading to the formation of plaque in the blood vessels, Dr. Awad says. When blood vessels start to form plaque, the heart has to work harder, he explains.

There are a lot of reasons for this, Dr. Winter says. When youre fatigued, your brain prioritizes getting sleep over other things, he says. But Dr. Winters says other chemicals that are important for sexual performance and arousal, such as oxytocin, can be lowered by sleep deprivation.

One study in JAMA restricted 10 men's sleep for a week and found that the levels of the sex hormone testosterone in their bodies decreased by up to 15%. (Testosterone is a hormone that can fuel a person's sex drive.) The reverse is also true: Another study published in JAMA found that people who got more sleep than usual were more likely to have sex the next day. Meaning, if you hit the hay earlier, you just might be up for a little something extra.

nadia_bormotovaGetty Images

There are a few reasons for this. One is that people tend to make bad eating decisions when theyre tired, Dr. Winter says. People are also typically more sedentary and less likely to work out when theyre tired, which also can lead to weight gain, he says.

Research published in the journal Sleep found that people with restricted sleep had altered levels of endocannabinoids, one of the chemical signals that affect appetite, and the brains reward system. The researchers also discovered that when people were sleep-deprived, they ate more and unhealthier snacks between meals, at the same time that endocannabinoid levels were at their highest.

Older research has also found that women who get less sleep tend to weigh more than their better-rested counterparts, likely for the reasons above, Dr. Winter says.

Theres a direct correlation between lack of sleep and diabetes, Dr. Awad says. Its due to your bodys ability to regulate insulin, a hormone produced in the pancreas that controls your blood sugar, he says. Lack of sleep reduces the production of insulin from the pancreas and decreases gluten tolerance, Dr. Awad says. Cells are then less effective at using insulin, and that can lead to the development of diabetes.

To be clear: Sleep deprivation isnt cited by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as a potential cause of diabetes, but insulin resistancewhich can be caused by lack of sleepis.

How to finally get more shut-eye

If youre struggling with sleep, Dr. Winter recommends first trying to prioritize rest and practicing good sleep hygiene. That includes the following, per the CDC:

If these tried-and-tested tips dont help, Dr. Awad says its a good idea to talk to your doctor about what else you can do to get the rest your body needs.

This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at piano.io

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Preventive Medicine Market : Business Growth, Development Factors, Applications, and Future Prospects – The Haitian-Caribbean News Network

Friday, December 4th, 2020

Global Preventive Medicine Market: Snapshot

Preventive Medicine is kind of a medical practice that goes by the principle of prevention is better than cure. It includes all the steps taken for preventing the illness and opposes procedure of treatment. Preventive medicine is able to decrease the cases of non-contagious ailments for example, diabetes, tumor, and cardiovascular diseases.

The ongoing examination give an account of global preventive medicine market exhibits a point by point investigation if various parts of the market, for example, limitations, drivers, market figures, and different portions on which the market is relied. This gives a good thought regarding the current and the past market situation to the customers. It is required to settle on their choice further for the market speculation.

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Global Preventive Medicine Market: Trends and Opportunities

The key supporter of the development of global preventive medicine market is rising costs of drugs, recovery medicines, surgeries, and medical gadgets. The pharmaceutical organizations are taking increasingly more interest for preventive drug as they are confronting issues with the customary pharma model, which is neither gainful nor satisfying the demand. Consequently the pharma business has distinguished a sustainable model in preventive medication. This has amazingly contributed towards the market development. Changing attention to individuals alongside expanding reach of eductaion has likewise increased the value of the market development. Be that as it may, the accomplishment of the preventive drug requires an enormous alliance of pharma industry including huge players and new companies with corporate associations and colleges/scholastic organizations, which is uncommon. This is the significant misfortune for preventive drug market. Lack of regional confirmations referring to preventive drug is a huge strategy to shield one from sicknesses may likewise restrain the development. Another factor constraining development is that counteractive action medications capability to confine the healthcare usage has not yet acknowledged on a vast scale in light of the fact that the arrival on venture has never been imparted, keeping individuals enthusiasm for this field under control.

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Global Preventive Medicine Market: Regional Analysis

North America is falling behind different nations to the extent preventive drug market is concerned in view of absence of interest of individuals. As indicated by a journal, Health Affairs, USA will spare just 0.2% of medicinal services payment notwithstanding when 90% of the populace utilize preventive administrations. Hardly any different investigations have likewise shown that preventive measures dont bring down the danger of genuine disease or unexpected passing. European preventive market is developing admirably on account of achievements of the hazard figure the study of disease transmission the locale, which has prompted the authorization of a wide-scope of preventive measures, for example, authoritative arrangements to confine tobacco publicizing and smoking in open spots, wellbeing training for weight, network special occasions for hypertension checking and so on.

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Global Preventive Medicine Market: Competitive LAndscape

The key players operating in the global preventive medicine market include Eli Lilly, Novo Nordisk, Quanterix, Aetna Inc., Cancer Prevention Pharmaceuticals, Inc., Preventive Medical Health Care Co., LTD., American College of Preventive Medicine and U.S. Preventive Medicine., and Phoenix Medicine.

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Each TMR Syndicated Research report covers a different sector such as pharmaceuticals, chemical, energy, food & beverages, semiconductors, med-devices, consumer goods and technology. These reports provide in-depth analysis and deep segmentation to possible micro levels. With wider scope and stratified research methodology, our syndicated reports thrive to provide clients to serve their overall research requirement.

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SC says will clarify position on homeopathic preventive treatment for COVID, reserves verdict – The New Indian Express

Friday, December 4th, 2020

By PTI

NEW DELHI:The Supreme Court on Tuesday said that there was lack of clarity in the Ministry of Ayush advisory on allowing homeopathic medical practitioners to prescribe even add-on or preventive treatment for COVID-19 patients.

The top court said that it would clarify the position and reserved its verdict on a plea challenging the Kerala High Court order which had said that AYUSH medical practitioners can prescribe government approved mixtures and tablets only as immunity booster for COVID-19 The Centre told the top court that medicines which are permitted to be prescribed by the Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy) to COVID positive patients as an add-on treatment was allowed.

A bench of Justices Ashok Bhushan, R S Reddy and M R Shah said it would like to clarify the position on allowing homeopathic doctors to prescribe prophylactic interventions for improving the immunity of COVID-19 positive patients.

Solicitor General Tushar Mehta, appearing for Centre said that as per the advisory dated March 6, of Ministry of AYUSH, homeopathic practitioners cannot prescribe medicines for COVID-19 treatment but can prescribe drugs which are preventive in nature like for immunity boosting.

He said that an affidavit has been filed by the Ministry in this regard, which the bench took into record.

The top court was hearing an appeal against the Kerala High Court order of August 21.

The affidavit said, "Thus in the respectful submission of the answering respondent, prescription of the medication prescribed by the Ministry of AYUSH to COVID positive patients as an add-on treatment is permitted, and therefore, any contention to the contrary stating that homeopathic medical practitioner cannot prescribe any treatment to COVID-19 positive patients, even as an add-on to conventional treatment is liable to be rejected".

The Ministry said in its affidavit that, "It is stated that the only embargo is that the said medicines should not be administered or advertised as a cure but should be administered as preventive measure/immunity booster or as an add-on to the conventional treatment".

It said that the Ministry of AYUSH had clearly provided that administration of the medicine was to be done only as a preventive measure and the same should not be claimed as a treatment advice for the Coronavirus infection.

The affidavit said that the Ministry of AYUSH has clearly permitted the homeopathic medical practitioners to prescribe the drugs, as mentioned in the guidelines, as an add-on drug to the conventional treatment for patients who have been tested COVID positive and are undergoing conventional treatment.

The Ministry of AYUSH said that drugs which can be prescribed by a homeopathic medical practitioner are for preventive and prophylactic use, for symptom management of COVID-19 like illnesses; and add on interventions to the conventional care.

It said that all these medicines are to be administered as a preventive measure or as an add-on to the conventional treatment and should not be treated and/or prescribed as a cure.

The Ministry further said that its Guidelines for Registered Practitioners of respective system of AYUSH including Homoeopathy have been prepared by Director Generals of Research Councils and Directors of National Institutes with their team of experts and after vetting by the Interdisciplinary AYUSH Research and Development Task Force of Ministry of AYUSH.

"While noting and acknowledging the role played by homoeopathy medical practices for preventing the spread of diseases like Chikungunya, Dengue Fever, Japanese Encephalitis and Cholera with good results, the Ministry of Ayush prescribed the intervention and preventive management steps under the homeopathic practices at three stages-- preventive and prophylactic, symptom management of COVID- 19 like illnesses and add on interventions to the conventional car," it said.

On November 19, the top court had observed that everybody cannot be allowed to prescribe medicines.

The high court had passed the order on a plea which had sought a direction to the state authority to ensure that homoeopathic practitioners are immediately allowed to perform in accordance with the March 6 notification of the Ministry of AYUSH, which had said that state government shall take steps to adopt homoeopathic system among other systems of medicines in the fight against the menace of Coronavirus.

"Advisory of the Ministry of AYUSH is being followed by the government and tablets are given free of cost to those persons as immunity boosters.

As per the state medical protocol, COVID-19 affected persons should not be treated by anybody other than the government and those authorised by the government," the high court had noted in its order.

The high court had further noted that as per the medical protocol of the government, doctors practising in AYUSH medicines are not supposed to prescribe any medicines stating that it is curative for COVID-19 disease.

"However, as per the advisory, there is nothing prohibiting the qualified medical AYUSH practitioners to prescribe immunity booster mixture or tablets, as suggested by the Ministry of AYUSH, Government of India, New Delhi," it had said.

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CDC Committee Votes on Prioritizing US Population for COVID-19 Vaccine – Contagionlive.com

Friday, December 4th, 2020

With an overwhelming vote of 13 to 1, The Centers for Disease Control and Preventions (CDC) Advisory Committee on Immunization Practices (ACIP) has decided to put health care providers and long-term care residents at the top of the priority list for the impending COVID-19 vaccines, once they are US Food and Drug Administration (FDA) approved.

Yesterdays vote was formally recognizing the ACIP's previous recommendations on how to allocate the forthcoming COVID-19 vaccines. Healthcare personnel are part of phase 1A, the first group to be vaccinated. This group includes personnel who work in the following facilities including: hospitals, long-term care facilities, outpatient home health care, pharmacies, emergency medical personnel, and public health workers.

With the news that the Pfizer and BioNtechs vaccine was approved in the United Kingdom today, and with scheduled FDA meetings for both the Pfizer/BioNtech and Moderna vaccines later this month, the United States may have 2 approved COVID-19 vaccines in the next few weeks.

One of the biggest takeaways from last weeks meeting was the panel and participants taking part in the discussion wanted to inform the public and clinicians that the COVID-19 vaccines could bring on local side effects having vaccine recipients feeling flu-like.

The concern is that if people who get vaccinated and feel flu-like after the first dose, there might be reluctance to take a second dose a month later, thereby not giving that vaccinated person the needed immunity from the virus.

The ACIP includes 15 voting members responsible for making vaccine recommendations. Fourteen of the members have expertise in vaccinology, immunology, pediatrics, internal medicine, nursing, family medicine, virology, public health, infectious diseases, and/or preventive medicine; one member is a consumer representative who provides perspectives on the social and community aspects of vaccination.

In addition to the 15 voting members, ACIP includes eight ex officio members who represent other federal agencies with responsibility for immunization programs in the United States, and 30 nonvoting representatives of liaison organizations that bring related immunization expertise.

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Preventive Medicine Market Size, Key Manufacturers, Demand, Application And Opportunities By 2027 – The Haitian-Caribbean News Network

Friday, December 4th, 2020

New Jersey, United States: Market Research Intellect has added a new report to its huge database of research reports, entitled Preventive Medicine Market Size and Forecast to 2027. The report offers a comprehensive assessment of the market including insights, historical data, facts, and industry-validated market data. It also covers the projections using appropriate approximations and methods.

Preventive Medicine Market Overview

The Preventive Medicine Market Report provides comprehensive data on market dynamics, market trends, product growth rate, and price. The Preventive Medicine market report has various facts and statistics assuming the future predictions of the upcoming market participants. In addition, it offers business security taking into account sales, profit, market volume, demand and market supply ratio. The in-depth study provides vital information related to market growth, driving factors, major challenges, opportunities, and threats that will prove to be very helpful for market participants in making upcoming decisions.

Preventive Medicine Market: Competitive Landscape

The Preventive Medicine Market report consists of the Competitive Landscape section which provides a complete and in-depth analysis of current market trends, changing technologies, and enhancements that are of value to companies competing in the market. The report provides an overview of sales, demand, futuristic costs and data supply as well as a growth analysis in the forecast year. The key vendors in the market that are performing the analysis are also clearly presented in the report. Their development plans, their growth approaches, and their merger and acquisition plans are also identified. Information specific to a keyword in each of these regions is also provided. This report also discusses the submarkets of these regions and their growth prospects.

Prominent players operating in the market:

Preventive Medicine Market Segmentation

The report contains the market size with 2019 as the base year and an annual forecast up to 2027 in terms of sales (in million USD). For the forecast period mentioned above, estimates for all segments including type and application have been presented on a regional basis. We implemented a combination of top-down and bottom-up approaches to market size and analyzed key regional markets, dynamics and trends for different applications.

Preventive Medicine Market Segment by Type:

Preventive Medicine Market Segment by Application:

Preventive Medicine Market Regional overview:

In the report, experts analyze and forecast the Preventive Medicine market on a global as well as regional level. Taking into account all aspects of the market in terms of regions, the focus of the report is on North America, Europe, Asia Pacific, the Middle East and Africa, and South America. The prevailing trends and various opportunities in these regions are studied that can convince the growth of the market in the forecast period 2020 to 2027.

Reasons to Buy the Preventive Medicine Market Report:

Outlook analysis of the Preventive Medicine market sector with current trends and SWOT analysis. This study evaluates the dynamics, competition, industrial strategies and strategies of the emerging countries. This report has a comprehensive guide that provides market insights and detailed data on each market segment Market growth factors and risks are presented. More precise information provision on the Preventive Medicine market for different countries. Provide visions on factors influencing the growth of the market. Market segmentation analysis, including quantitative and qualitative research considering the impact of economic and non-economic aspects Comprehensive company profiles with product offerings, important financial information and the latest developments.

If you have any custom requirements, please let us know and we will offer you the customized report as per your requirements.

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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

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Heart disease risk in women increases leading up to menopause; early intervention is key – Niagara Frontier Publications

Friday, December 4th, 2020

Wed, Dec 2nd 2020 02:20 pm

By the American Heart Association

The menopause transition, the years leading up to menopause, is a time of increasing heart disease risk for women. Monitoring womens health and lifestyle, while integrating early intervention strategies for good cardiovascular health, are important, especially during midlife and during menopause to help prevent heart disease, according to a new scientific statement from the American Heart Association, Menopause Transition and Cardiovascular Disease Risk: Implications for Timing for Early Prevention, recently published in its flagship journal,Circulation.

Over the past 20 years, our knowledge of how the menopause transition might contribute to cardiovascular disease has been dramatically evolving, said Samar R. El Khoudary, Ph.D., M.P.H., FAHA, chair of the statement writing committee and associate professor of epidemiology at the University of Pittsburghs Graduate School of Public Health and the Clinical and Translational Science Institute. We have accumulated data consistently pointing to the menopause transition as a time of change in cardiovascular health. Importantly, the latest American Heart Association guidelines that are specific to women, which were published in 2011, did not include the data that is now available on menopause as a time of increased risk for womens heart health. As such, there is a compelling need to discuss the implications of this accumulating body of literature on this topic.

For many women, the menopause transition the change from the reproductive to the nonreproductive phase of life marked by changes in menstruation begins when they are in their late 40s to mid-50s. Before this transition, women produce estrogen, the female sex hormone, which may also have cardio-protective effects. When women go through the natural menopause transition, their ovaries stop producing as much estrogen. This can also occur through surgical menopause (a partial or full hysterectomy, which includes removal of one or both ovaries). Significant changes in a womans cardiometabolic and vascular health, which lead to higher heart disease risk, occur during the menopause transition.

Since the increase in heart disease risk during menopause is associated with a decrease in the production of the hormone estrogen, health care professionals and scientists have studied if hormone therapy might help reduce cardiovascular risk. There is research indicating potential cardiovascular benefits of certain combinations of hormone therapy when initiated in early but not late menopause. Further research is needed to evaluate the role of other hormone therapies, and how long these interventions impact cardio-metabolic health.

Additionally, some studies show the benefits of hormone therapy, including a decreased risk of type 2 diabetes and protection from bone loss, seem to outweigh the risks for most women in early menopause. Current recommendations from leading professional medical societies endorse the use of hormone therapy for women who have recently begun the menopause transition, with appropriate indications.

This scientific statement aims to raise awareness for both health care professionals and women about the significant adverse cardiovascular health changes accompanying midlife and the menopause transition and point out the importance of adopting prevention strategies early during this stage, El Khoudary said. As such, it emphasizes the importance of monitoring womens health during midlife and targeting this stage as a critical window for applying early intervention strategies that aim to maintain a healthy heart and reduce the risk of heart disease. Thus, health care professionals may consider an aggressive, prevention-based approach for women during this stage in their lives to decrease the probability of a future cardiovascular disease occurrence, such as heart attack or stroke.

In addition to summarizing research focused on the use of hormone therapy, the scientific statement provides an overview of risks related to the stages of menopause, age at menopause and lifestyle factors that affect womens risk during this time.

Key takeaways in the statement include the following:

Some of the common symptoms felt with menopause have a correlation with cardiovascular disease. Hot flashes and night sweats are associated with worse cardiovascular disease risk factor levels. Depression and sleep disturbances, linked in some studies to an increased risk of heart disease, are also common among women during this time.

Physiological changes during menopause, such as increased abdominal fat and visceral fat (body fat around the organs), are associated with a heightened risk of all-cause, cardiovascular disease and cancer mortality, even among those with normal body mass index levels.

Cholesterol levels,metabolic syndromerisk and vascular vulnerability appear to increase with menopause beyond the effects of normal aging. Metabolic syndrome is diagnosed when a person has three or more of the following measurements: abdominal obesity, high triglycerides, low HDL cholesterol (the good cholesterol), high blood pressure and/or high blood glucose levels (blood sugar).

Novel data show a reversal in the associations of HDL cholesterol (the good cholesterol) with heart disease risk over the menopause transition, suggesting higher good cholesterol levels may not consistently reflect good heart health in all stages of life in women.

Data about the use of cholesterol-lowering medications remains limited for women going through the menopause transition and requires further study so evidence-based recommendations can be developed.

Women who experience menopause at an earlier age have a higher risk of heart disease. A womans age at menopause can be influenced by factors such as length of menstrual cycle, poor cardiovascular risk profile during reproductive years and socioeconomic factors. Race and ethnicity also play a role, with many Hispanic and Black women experiencing menopause at younger ages.

Physical activity and nutrition may play a role in the timing of menopause for all women. Women who drink little to moderate amounts of alcohol may have later onset of menopause, and those who smoke cigarettes are likely to start menopause about a year earlier than non-smokers.

There is, however, limited information on what is ideal in terms of lifestyle changes (such as the AHAsLifes Simple 7) for women during menopause. Data does indicate that only 7.2% of women in menopause meet physical activity guidelines, and fewer than 20% of those women consistently maintain a healthy diet.

Lifestyle and behavioral interventions are critical to maintaining cardiovascular health and reduce heart disease. However, we do not have adequate randomized clinical trials testing these interventions specifically during the menopause transition, said Matthew A. Allison, M.D., M.P.H., FAHA, vice chair of the statement writing committee and professor and chief of the division of preventive medicine in the department of family medicine and public health at the University of California San Diego. Similarly, we need randomized clinical trials of therapeutic interventions, like cholesterol-lowering medications and menopause hormone therapy, in women who are transitioning through menopause. This at-risk population has not been the focus of previous clinical trials, thus leaving us with questions about how the results from these studies might apply to women during this earlier phase of menopause.

The scientific statement was developed by the writing group on behalf of the American Heart Associations prevention science committee of the council on epidemiology and prevention, and the Council on Cardiovascular and Stroke Nursing.

Co-authors and members of the writing committee additionally include Brooke Aggarwal, Ed.D., M.S., FAHA.; Theresa M. Beckie, Ph.D., FAHA; Howard N. Hodis, M.D., FAHA; Amber E. Johnson, M.D., M.S., M.B.A.; Robert D. Langer, M.D., M.P.H., FAHA; Marian C. Limacher, M.D., FAHA; JoAnn E. Manson, M.D., Dr.P.H., FAHA; and Marcia L. Stefanick, Ph.D., FAHA. Author disclosures are in the manuscript.

The American Heart Association is a relentless force for a world of longer, healthier lives.We are dedicated to ensuring equitable health in all communities.Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public's health and share lifesaving resources.The Dallas-based organization has been a leading source of health information for nearly a century.Connect with us onheart.org,Facebook orTwitter,or by calling 1-800-AHA-USA1.

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Heart disease risk in women increases leading up to menopause; early intervention is key - Niagara Frontier Publications

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Here’s how Utah’s first vaccinations will be distributed and when you will get yours – Salt Lake Tribune

Friday, December 4th, 2020

(Hans Pennick | Associated Press file photo) Nurse Kathe Olmstead prepares a shot that is part of a possible COVID-19 vaccine, developed by the National Institutes of Health and Moderna Inc., in Binghamton, N.Y., in July 2020.

| Dec. 3, 2020, 6:31 p.m.

| Updated: Dec. 4, 2020, 1:35 a.m.

Front-line health care workers at five large hospitals will be the first people in Utah to receive the COVID-19 vaccine, officials for those hospitals confirmed Thursday.

Under the states distribution plan, people at higher risk of getting sicker from COVID-19 will start receiving the vaccine from February through May. The general public is expected to get the vaccine by June or July.

Gov. Gary Herbert, speaking Thursday at his weekly COVID-19 news briefing, said he hopes more vaccines could arrive even sooner.

We hopefully will have enough vaccines that by springtime March, April, May of this year everybody who wants to have a vaccine will be able to have a vaccine, he said. Thats going to help us slow the spread and give us relief, and start to help us recover and have more normal socialization.

The first batch of vaccines will be distributed to the five Utah hospitals, so they can be given out as soon as the U.S. Food and Drug Administration approves an emergency use authorization of the vaccine which is expected the week of Dec. 14.

The five hospitals were chosen, Dascomb said, because they are handling a large number of the states COVID-19 patients and because they have the supercold freezers needed to store the Pfizer vaccine at temperatures of 80 below zero Celsius.

The Pfizer product is a very fragile and unstable virus vaccine, and has to be handled very carefully, Mayer said. Weve got the minus-80 freezers. Weve got the backups to the backups.

The health department estimates there are about 126,000 health care workers in Utah, Hudachko said. The state doesnt know how many of those would receive the first batch of vaccines.

Those front-line workers include doctors and nurses who treat COVID-19 patients, specialists at high-risk of exposure (such as anesthesiologists), and for hospital housekeepers who come in contact with infected materials.

Housekeepers, Mayer said, have been the hardest hit during this pandemic.

Mayer said University Hospital expects to dole out between 500 and 750 doses a day, and Dascomb said the four Intermountain hospitals will be working on a similar schedule. They said the hospitals would work to schedule vaccinations so workers at the same hospital units werent all treated the same day and that the shots would be given so workers could take a day or two off if they develop side effects.

The trial studies for the Pfizer vaccine and a second vaccine made by Moderna, expected to get FDA approval in late December, have shown few side effects, said Dr. Andrew Pavia, chief of pediatric infectious disease at University of Utah Health. That doesnt mean side effects wont show up when thousands and millions of people get the vaccines, he said.

Well be keeping very close eyes on the long-term safety, Pavia said. Its a relatively new vaccine, and we dont have years of experience with it.

Pavia noted that the odds of serious side effects are one in thousands, while the odds of dying if one is infected with the coronavirus is 1 in 150. The benefits of preventing the disease, he said, will outweigh the risks of taking the vaccine.

Health care workers at Intermountain and University of Utah Health wont be required to take the vaccine, officials at both hospital systems said.

Workers will be presented with the data, so they can make an informed choice, said Dr. Tamara Sheffield, medical director of Intermountains community health and prevention department.

Herbert said the state government has no plans to mandate COVID-19 vaccines when they become available to the public.

We think that most of the people in Utah will want to have one, Herbert said, to protect themselves and their loved ones.

Businesses, Herbert said, likely could require their employees to get vaccinated. It would be entirely within their abilities, their constitutional rights as an employer, to say, If youre going to come to work for me, I want to make sure you have the vaccine, so we dont get people sick here on the job.

Both the Pfizer and Moderna vaccines require two doses, taken weeks apart. The plan is to distribute all the Pfizer doses immediately, with more shipments expected to arrive in the coming weeks to cover the second dose.

Mayer said the health department has assured the hospitals that they will receive enough vaccines to cover the second doses.

Pavia noted that the vaccine landscape is constantly changing. A third vaccine, developed by AstraZeneca and Oxford University, is in clinical trials. And both Pfizer and Moderna, he said, are starting trials for 12- to 17-year-olds.

The distribution is complex, and its evolving, Pavia said. By the time spring rolls around, we may have three or four vaccines.

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Here's how Utah's first vaccinations will be distributed and when you will get yours - Salt Lake Tribune

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Allergy Publishes Results from BioCryst’s APeX-J Trial of Oral, Once-Daily Berotralstat for the Prevention of HAE Attacks – GlobeNewswire

Friday, December 4th, 2020

RESEARCH TRIANGLE PARK, N.C., Nov. 30, 2020 (GLOBE NEWSWIRE) -- BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) today announced the journal Allergy has published data from the APeX-J trial, a randomized, placebo-controlled trial conducted in Japan evaluating oral, once-daily berotralstat for the prophylactic treatment of hereditary angioedema (HAE).

The APeX-J trial met its primary endpoint of a reduction in the rate of HAE attacks for berotralstat 150 mg compared to placebo during the 24-week period (p=0.003). Berotralstat was safe and generally well-tolerated in the trial.

These results are consistent with the global phase 3 APeX-2 trial, where berotralstat 150 mg also reduced the rate of HAE attacks compared to placebo (p<0.001) and was safe and generally well-tolerated.

APeX-J is the first placebo-controlled trial of an HAE medicine conducted in Japan and the berotralstat data are very exciting for patients, who currently have no approved prophylactic treatment options. Based on the safety and efficacy profile, I believe berotralstat, if approved, would be an important advancement in HAE management for Japanese patients, said Dr. Isao Ohsawa, president of Saiyu Soka hospital and principal investigator of the APeX-J trial.

Dr. Ohsawa and the study authors note that HAE is estimated to affect 2,500 patients in Japan and the recognition of HAE by physicians is low. Although two on-demand treatments are approved, no therapies are currently approved for long-term prophylaxis in Japan.

Berotralstat would be the first approved prophylactic therapy for HAE patients in Japan and we believe there is a significant opportunity for berotralstat to accelerate the diagnosis of HAE patients and dramatically improve the quality of life for patients, said Jon Stonehouse, president and chief executive officer of BioCryst.

A new drug application (JNDA) is under review in Japan for approval of oral, once-daily berotralstat for the prophylactic treatment of HAE. Berotralstat is being reviewed under Sakigake designation and the company expects a decision on approval in December 2020.

Torii Pharmaceutical, Co., Ltd. is BioCrysts commercial partner in Japan for berotralstat.

About BioCryst Pharmaceuticals

BioCryst Pharmaceuticals discovers novel, oral, small-molecule medicines that treat rare diseases in which significant unmet medical needs exist and an enzyme plays a key role in the biological pathway of the disease. BioCryst has several ongoing development programs including ORLADEYO (berotralstat), an oral treatment for hereditary angioedema, BCX9930, an oral Factor D inhibitor for the treatment of complement-mediated diseases, galidesivir, a potential treatment for COVID-19, Marburg virus disease and Yellow Fever, and BCX9250, an ALK-2 inhibitor for the treatment of fibrodysplasia ossificans progressiva. RAPIVAB (peramivir injection), a viral neuraminidase inhibitor for the treatment of influenza, is BioCryst's first approved product and has received regulatory approval in the U.S., Canada, Australia, Japan, Taiwan, Korea and the European Union. Post-marketing commitments for RAPIVAB are ongoing. For more information, please visit the Company's website at http://www.BioCryst.com.

Forward-Looking Statements

This press release contains forward-looking statements, including statements regarding future results, performance or achievements. These statements are identified by use of terms such as believe, will, would, expect, and similar words, although some forward-looking statements may be expressed differently. These statements involve known and unknown risks, uncertainties and other factors which may causeactual results, performance or achievements to be materially different from any future results, performances or achievements expressed or implied by the forward-looking statements. These statements reflect our current views with respect to future events and are based on assumptions and are subject to risks and uncertainties. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Some of the factors that could affect the forward-looking statements contained herein include: the ongoing COVID-19 pandemic, which could create challenges in all aspects of BioCrysts business, including without limitation delays, stoppages, difficulties and increased expenses with respect to BioCrysts and its partners development, regulatory processes and supply chains, negatively impact BioCrysts ability to access the capital or credit markets to finance its operations, or have the effect of heightening many of the risks described below or in the documents BioCryst files periodically with the Securities and Exchange Commission; developing and commercializing ORLADEYO or any HAE product candidate may take longer or may be more expensive than planned; BioCryst may not be able to enroll the required number of subjects in planned clinical trials of product candidates; BioCryst may not advance human clinical trials with product candidates as expected; the FDA, EMA, PMDA or other applicable regulatory agency may require additional studies beyond the studies planned for product candidates, may not provide regulatory clearances which may result in delay of planned clinical trials, may impose certain restrictions, warnings, or other requirements on product candidates, may impose a clinical hold with respect to such product candidates, or may withhold or delay market approval for product candidates; product candidates, if approved, may not achieve market acceptance; BioCrysts ability to successfully commercialize its product candidates, manage its growth, and compete effectively; and risks related to the international expansion of BioCrysts business. Please refer to the documents BioCryst files periodically with the Securities and Exchange Commission, specificallyBioCrystsmost recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K, all of which identify important factors that could cause the actual results to differ materially from those contained inBioCrystsforward-looking statements.

BCRXW

Contacts:John Bluth+1 919 859 7910jbluth@biocryst.com

Catherine Collier Kyroulis+1 917 886 5586ckyroulis@biocryst.com

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Allergy Publishes Results from BioCryst's APeX-J Trial of Oral, Once-Daily Berotralstat for the Prevention of HAE Attacks - GlobeNewswire

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