StemCell Therapy

A policy initiative was set up 5 years ago with the goal of spreading the adoption of a therapeutic strategy to maximize the brain health of every person with MS. The principle idea was that MS should be treated as effectively as early as possible, said Gavin Giovannoni, MBBCh, PhD, FCP (Neurol., SA), FRCP, FRCPath, chair of neurology at the Blizard Institute in the Barts and The London School of Medicine and Dentistry at Queen Mary University of London.

This means intervening early and effectively to affect the trajectory of MS over time. Im convinced we are doing this now, he said.

In the predisease-modifying therapy (DMT) era, by age 65, more than 80% of patients with MS needed a walking stick1. However, by the era of low-efficacy DMTs, that proportion was down to 60%, and now, in the high-efficacy era of DMTs, that proportion has fallen further, to 20% to 30% of patients needing a walking stick by the age of 65.

So, theres no doubt that by adopting this early, effective treatment approach, we have a major impact on the overall outcome, Giovannoni explained.

However, the challenge remains: how do we determine which patients with MS will respond to treatments? If there are 100 patients, its not clear who will or wont respond to therapy, and the only real option is to use statistical modeling.

Providers have to decide if they want to gamble on low- or high-efficacy therapies when they initiate treatment. Should they start with low-efficacy and move through the tiers or go right to the top tier from the outset?

Research has shown that early access to high-efficacy DMTs results in better outcomes. For fingolimod, natalizumab, and alemtuzumab the response rates are much higher, and they are associated with a lower risk of conversion to secondary progressive MS compared with therapies like interferon beta or glatiramer acetate.2 In addition, patients who started on high-efficacy therapies within 2 years of disease onset had less disability after 6 to 10 years than patients who started high-efficacy therapy later in the disease course.3

Theres little doubt in my mindearly access is whats important, Giovannoni said. Early access not late access.

However, treatment is not only about efficacypatients are going to be exposed to serious adverse events on these therapies. This is when patient choice becomes important. Providers will need to take into account issues like family planning and pregnancy when personalizing treatments.

Thats why safety comes into it, Giovannoni said. We always worry about the serious adverse event when we are customizing treatment strategies for patients with multiple sclerosis.

At baseline, the provider needs to look for ways to de-risk the high-efficacy DMTs to make them more palatable for patients to try as a first-line therapy.

Understanding the individuals disease is crucial, including profiling the patient in terms of understanding their risk aversion, adherence, comorbidities, and other factors before customizing treatment However, once that is done, it must be layered onto the health system and economic factors, he pointed out.

So, there is not a simple solution to the customized medicine in relation to our disease-modifying therapy, Giovannoni said.

Subgroup analyses to understand response rates

Predicting a better response to treatments is very important in MS now that there are multiple treatment options to choose from, said Maria Pia Sormani, professor of biostatistics at the University of Genoa, Italy.

However, it is not easy to define response to treatment in MS. For instance, in solid tumors, a reduction in the tumor mass after chemotherapy is defined as a response to treatment because there is no spontaneous mass reduction without treatment. In relapsing-remitting MS, simply having no relapses after an immunomodulatory drug cannot be defined as having a response to treatment, because in the disease, patients can have stable disease course even without treatment.

A subgroup analysis can help better understand patients who are responders to therapy, she explained. One study of cladribine tablets showed that while the overall risk reduction versus placebo was 50%, there were differences in response depending on disease activity.4 In patients with high disease activity, the probability of disease progression was reduced by more than 80% among patients who took cladribine; the reduction was less than 20% in patients without high disease activity.

Sometimes, when many subgroups are tested, researchers will find by chance that some subgroups have a higher response to treatment, but that finding might not be confirmed in a follow-up study, Sormani noted.

Another analysis showed that in the DEFINE study,5 patients with no prior MS treatment had a relapse risk reduction of 67% when treated with oral BG-12 (dimethyl fumarate), but in the CONFIRM study,6 the opposite was true: the reduction was only 36% in patients with no MS treatment, and the risk reduction was larger in patients who had previous treatment (54%).

A new approach that Sormani and her colleagues crafted would create a personalized profile of patients who respond better using a patient-specific continuous score.7 They applied the analysis to 3 trials: ALLEGRO was used to define the score; BRAVO was used to test the score; and CONCERTO was used to externally validate the findings.

The score was able to define responders and nonresponders, and Sormani provided an example of how it might be applied in clinical practice. First instance, take a patient with MS with 1 relapse in the previous year, 1 gadolinium-enhancing lesion on the baseline scan, and a normalized brain volume of 1600 cm3:

In conclusion, Sormani noted that there are now statistical techniques based on post-hoc analyses of clinical trials that can help identify which patients will benefit the most from which treatments in order to choose the best MS therapy for them.

We must try to push on pharmaceutical companies to allow re-analysis of their clinical trials to identify subgroup responders to every drug, she said.

References

1. Capra R, Cordioli C, Rasia S, Gallo F, Signori A, Sormani MP. Assessing long-term prognosis improvement as a consequence of treatment pattern changes in MS. Mult Scler. 2017;23(13):1757-1761. doi:10.1177/1352458516687402

2. Brown JWL, Coles A, Horakova D, et al. Association of initial disease-modifying therapy with later conversion to secondary progressive multiple sclerosis. JAMA. 2019;321(2):175-187. doi:10.1001/jama.2018.20588

3. He A, Merkel B, Brown JWL, et al. Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study. Lancet Neurol. 2020;19(4):307-316. doi:10.1016/S1474-4422(20)30067-3

4. Giovannoni G, Soelberg Sorensen P, Cook S, et al. Efficacy of cladribine tablets in high disease activity subgroups of patients with relapsing multiple sclerosis: a post hoc analysis of the CLARITY study. Mult Scler. 2019;25(6):819-827. doi:10.1177/1352458518771875

5. Bar-Or A, Gold R, Kappos L, et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study. J Neurol. 2013;260(9):2297-305. doi:10.1007/s00415-013-6954-7

6. Hutchinson M, Fox RJ, Miller DH, et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study. J Neurol. 2013;260(9):2286-96. doi:10.1007/s00415-013-6968-1

7. Pellegrini F, Copetti M, Bovis F, et al. A proof-of-concept application of a novel scoring approach for personalized medicine in multiple sclerosis. Mult Scler. 2020;26(9):1064-1073. doi:10.1177/1352458519849513

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Choosing the Right MS Treatment by Customizing Therapy to the Individual - AJMC.com Managed Markets Network

NEW YORK, Sept. 14, 2020 /PRNewswire/ --PulsePoint, the leading technology company using real-time data to accelerate health outcomes, is set to host their second bi-annual Digital Health Forum in October. Themed "The Future was Today," the event is designed around discussions aiming to disentangle many of the challenges within healthcare and rewrite an ideal vision that capitalizes on the opportunities technology and health data present.

PulsePoint prides itself in being a forward moving company, a sentiment captured in its corporate tagline, 'Leading Health Forward'. With this event, the company is leaning into the change we're currently going through and enlisting other forward-oriented minds to collectively re-envision how we use data and technology to help people make better health decisions.

Many big minds are trying to work through the current business challenges created by the pandemic. PulsePoint wants to look beyond, to address key issues facing healthcare, specifically around what health data will look like in five years, how rules are being re-written and what new behaviors are being formed. While no one can see that far ahead, PulsePoint is crafting the event to stimulate an exchange of ideas and creative thinking, with the ultimate goal of making us all more purposeful in charting a smart, productive and compassionate way forward.

The forum will feature an eclectic mix of multidisciplinary speakers including doctors, health policy officials, futurists, disruptors, technologists, journalists, non-profits, media personalities, and even teens representing the voices of tomorrow. Key headliners include Dr. Scott Gottlieb, former commissioner of the FDA, Bob Garfield, co-host of On the Media and Dr. Amy Zalman, CEO of Prescient and Professor of Foresight at Georgetown University.

PulsePoint's last Digital Health Forum, at Lincoln Center in 2018, focused on 'Radical Health Personalization' and explored topics such as consumer privacy, health data security, personalized medicine and humanitarianism in digital health.

"PulsePoint's Digital Health Forum is a foundational event for the health industry as data and technology intercepts with the huge transformational shift we are seeing in the market. The year 2020 will be viewed as a point in time when the health industry fundamentally embraced digital technology and finally turned their backs on the analog world that has slowed down its progress for so many years," said PulsePoint CEO, Sloan Gaon. "We're bringing experts together from different parts of health, technology and media to dig into what's new, what's next and what's actionable."

The event will be held virtually on October 6th. Register at TheFutureWasToday.com

About PulsePoint

We are a technology company using real time data to transform healthcare. Through machine learning and programmatic automation, we interpret the hard-to-read signals of the health journey to understand the connection points between relevance and engagement. We do this by unifying real-time Digital Determinants of Health, offline and clinical data to create a unique and precise view of health audiences that refines, improves and increases its view over time. Visit http://www.pulsepoint.com for more about the company's technology and award winning culture.

Contact: Maria Simeone [emailprotected]

SOURCE PulsePoint

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PulsePoint's Digital Health Forum 'The Future was Today' to Explore the Rapid Transformational Change Occurring Within Healthcare - PRNewswire

SAN FRANCISCO, Sept. 14, 2020 /PRNewswire/ -- The global artificial intelligence in drug discovery marketsize is expected to reach USD 3.5 billion by 2027, expanding at a CAGR of 28.8%, according to a new report by Grand View Research, Inc. The growing adoption of artificial intelligence (AI) platforms aimed at reducing the overall cost associated with drug discovery and to enhance results is expected to propel the demand for these platforms in the pharma market.

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Read 80 page research report with ToC on "Artificial Intelligence In Drug Discovery Market Size, Share & Trends Analysis Report By Therapeutic Area (Oncology, Cardiovascular Disease, Metabolic Diseases), By Application, By Region, And Segment Forecasts, 2020 - 2027'' at: https://www.grandviewresearch.com/industry-analysis/artificial-intelligence-drug-discovery-market

Based on the application, the drug optimization and repurposing segment accounted for the largest revenue share in 2019. AI platforms help in identifying alternative applications for existing medicines. This can help pharma companies diversify their portfolio of offerings and assist in producing alternative therapies through minor alterations in the pharmaceutical product. Furthermore, AI platforms also enable researchers to identify the toxic effects of the medicine on the body and thus reduce the chances of adverse effects.

In 2019, oncology application accounted for the largest share whereas, the infectious disease application segment is expected to emerge as the fastest-growing application segment over the forecast period. Artificial intelligence already plays a vital role in the early detection of cancer. Furthermore, as treatments for cancer may vary for each patient, personalized medicine has proven to be an effective alternative.

North America dominated the market with a revenue share of 59.4% in 2019 owing to the increasing adoption of artificial intelligence and the presence of a large number of market players. Asia Pacific is expected to emerge as the fastest-growing region in the market over the forecast period. The growing adoption of new technology in India and China for new drug development and a focus towards boosting pharmaceutical capacities within the countries is expected to drive the market in the region.

Grand View Research has segmented the global artificial intelligence in drug discovery market based on application, therapeutic area, and region:

List of Key Players of Artificial Intelligence In Drug Discovery Market

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About Grand View Research

Grand View Research, U.S.-based market research and consulting company, provides syndicated as well as customized research reports and consulting services. Registered in California and headquartered in San Francisco, the company comprises over 425 analysts and consultants, adding more than 1200 market research reports to its vast database each year. These reports offer in-depth analysis on 46 industries across 25 major countries worldwide. With the help of an interactive market intelligence platform, Grand View Research helps Fortune 500 companies and renowned academic institutes understand the global and regional business environment and gauge the opportunities that lie ahead.

Contact:Sherry JamesCorporate Sales Specialist, USAGrand View Research, Inc.Phone: +1-415-349-0058Toll Free: 1-888-202-9519Email: [emailprotected]Web: https://www.grandviewresearch.comFollow Us: LinkedIn| Twitter

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Artificial Intelligence In Drug Discovery Market Size Worth $3.5 Billion By 2027: Grand View Research, Inc. - PRNewswire

Robots welding at the assembly line of the French car maker Peugeot/Citroen in Brazil. Artificial intelligence offers a chance for the Latin America's economies to leapfrog to greater innovation and economic progress.

Photo: Antonio Scorza/AFP/ Getty Images

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E-commerce firms have faced a conundrum in Latin America: How can they deliver packages in a region where 25% of urban populations live in informal, squatterneighborhoods with no addresses?

Enter Chazki, a logistics startup from Peru, which partnered with Arequipas Universidad San Pablo to build an artificial intelligence robot to generate new postal maps across the country. The company has now expanded to Argentina, Mexico and Chile, introducing remote communities and city outskirts to online deliveries.

Thats just one example of how machine learning is bringing unique Latin American solutions to unique Latin American challenges. Artificial intelligence and its correlated technologies could prove a major boon to the regions public and private sectors. In turn, its policymakers and business leaders have to better prepare to take full advantage while warding off potential downsides.

Latin America has long been the victim of low productivity and the COVID-19 pandemic is predictably making matters worse. Now, artificial intelligence is a chance for the regions economies to leapfrog to greater innovation and economic progress. Research suggests that AI will add a full percentage point of GDP to five of South Americas biggest economies Argentina, Brazil, Chile, Colombia and Peru by 2035.

Artificial intelligence could play transformative roles in Latin America for just about every sector, according to the Inter-American Development Bank (IADB). That means using AI to predict trade negotiation outcomes, commodity prices and consumer trends, or developing algorithms for use in factories, personalized medicine, infrastructure prototyping, autonomous transportation and energy consumption.

AIs applications in Latin America are already becoming reality. Argentinian Banco Galicia, Colombian airline Avianca, and Brazilian online shopping platform Shop Fcil have all adopted chatbots as virtual customer service assistance to help people. Chiles The Not Company developed an algorithm that analyzes animal-based food products and a database of 400,000 plants to generate recipes for vegan alternatives, and Perus National University of Engineering built machines to autonomously detect dangerous gases.

Expect the trend to continue in the near future. An MIT global survey of senior business executives worldwide found that, by the end of 2019, 79% of companies in Latin America had launched AI programs. The results have been positive; fewer than 2% of respondents reported that the initiatives made lower-than expected returns.

Another key factor is public acceptance of AI and automation. Thus far, Latin Americans are ahead of the curve in embracing the future, with another recent poll showing that 83% of Brazilian consumers said they would trust banking advice entirely generated by a computer, compared to a global average of 71%.

In a region that suffers from endemic corruption, pervasive violence, weak institutions and challenging socioeconomic conditions, governments, policymakers and organizations can use AI to tackle critical issues in the region, including food security, smart cities, natural resources and unemployment.

In Argentina, for example, artificial intelligence is being used to predict and prepare for teenage pregnancy and school dropout, as well as to outline unseen business opportunities in city neighborhoods. In Colombia and Uruguay, software has been developed to predict where crimes are likely to occur. In Brazil, the University of So Paulo is developing machine-learning technology that will rapidly assess the likelihood that patients have dengue fever, Zika or chikungunya when they arrive at a medical center.

At a time when public support for democracy in Latin America is flailing, AI could help come to the rescue. Congressional bodies across the region could use AI to boost the transparency and input of the legislative process. Indeed, the Hacker Laboratory, an innovation lab within Brazils Chamber of Deputies, is using AI platforms to facilitate interactions between lawmakers and citizens.

AI is not risk-free, of course. Elon Musk called AI humanitys biggest existential threat, and Stephen Hawking said it could spell the end of the human race.

Apocalyptic scenarios aside, the immediate danger of AI in Latin America is unemployment and inequality. The Inter-American Development Bank (IADB) warned in a 2018 study that between 36% and 43% of jobs could be lost due to artificial intelligence as a result of automatization. Indeed, Latin Americas governments must be prepared to set up guardrails and implement best practices for the implementation of AI.

Several governments in the region have already announced AI public policy plans. Mexico was one of the first 10 countries in the world to create a national AI strategy. Meanwhile, Brazil launched anational Internet of Things plan, which includes the countrys commitment to a network of AI laboratories across strategic areas including cybersecurity and defense. Chile is coordinating with civil society groups and experts to adopt its own AI plan.

Move aside, Mercosur! Governments in Latin America might also find that machine learning strengthens regional ties. That means harnessing AI to crunch data on trade flows and rules, find areas of consensus in multilateral negotiations, or create algorithms for regional trade. After all, AI models have a 300% greater predictive capacity than traditional econometric models, according to the Inter-American Development Bank.

Beyond competing national plans for AI, Latin American leaders should be drafting a strategy that is specific to its region much like the European Union is doing. A key takeaway from the recent UNESCO Regional Forum on AI in Latin America and the Caribbean was that the technology must develop with respect to universally recognized human rights and values.

In 2021, artificial intelligence could generate almost $3 trillion in business value and 6.2 billion hours of productivity worldwide. Latin America is rightfully jumping onto the bandwagon and has the potential to lead the parade in some areas.

To make full use of what could be a transformational productivity revolution for the region, government and business leaders must pump more resources into technology planning and education. The implementation of AI must improve, not accelerate, the regions inequity.

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DGAP-News: Evotec SE / Key word(s): Miscellaneous14.09.2020 / 07:30 The issuer is solely responsible for the content of this announcement.

Hamburg, Germany, 14 September, 2020: Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809) and the French-based BIOASTER Technological Research Institute ("BIOASTER") today announced that they have entered into a partnership to advance research for infectious diseases. BIOASTER is a technology and innovation hub located in Lyon, France that has created a new model to address the latest challenges in the microbiology field, including antimicrobial resistance and vaccine safety and efficacy.

The organisations have been working together since the beginning of 2020 and Evotec represents the first global research and development company to locate staff in BIOASTER's premises in Lyon.

Under the terms of the collaboration agreement, the two organisations aim to put forward new research projects against infectious diseases and antimicrobial resistance, potentially creating new therapies and technologies. This collaboration had already started through the European research projects and development consortium ERA4TB (European Regimen Accelerator for Tuberculosis) and GNA NOW (Novel Gram-negative antibiotic now) within the AMR accelerator supported by the Innovative Medicines Initiative IMI2, aimed at reducing resistance to antibiotics and developing new therapeutic solutions.

"BIOASTER is proud to have support from the French and European leaders in diagnostics, vaccines, and animal health, and is pleased to formalise such a partnership with Evotec at the Lyon site. This allows BIOASTER to strengthen its agility and its capacity for technological innovation, in particular on antimicrobial resistance. BIOASTER now has a high-value network of close partners, which covers our four fields of application: antimicrobials, diagnostics, vaccines and microbiota understanding are key for manufacturers and patients alike," said Dr Philippe Archinard, President of IRT BIOASTER.

"The agreement will nurture the research ecosystem of Lyon Metropole and its Biodistrict, and impact on both national and European levels. The fact that Evotec, a company headquartered in Hamburg, Germany, chose to locate its unit dedicated to infectious diseases together with BIOASTER in the Biodistrict Lyon, reinforces the reputation of this French health ecosystem, while offering a more complete and more powerful technological toolbox to speed up industrialisation of innovations," said Emeline Baume, first vice president of Lyon Metropole.

"We are very glad to be partnering with BIOASTER, bringing Evotec's proven global resources for anti-infective research and drug development to Lyon," said Dr Werner Lanthaler, Chief Executive Officer of Evotec. "Both Evotec and BIOASTER have made a long-term commitment to tackle the challenge of antimicrobial resistance and we are confident that together we will be able to efficiently drive forward the progress in this field with high and rising unmet medical need."

The two entities gather more than 120 researchers in total, share the same advanced infrastructures, including five BSL3 laboratories, with easy access to diverse equipments: this co-location creates a new pole of attraction, particularly suited to the expectations of industrials to accelerate and de-risk their product developments in infectious diseases.

ABOUT BIOASTER TECHNOLOGICAL RESEARCH INSTITUTECreated in 2012, following the French initiative of Technological Research Institutes, BIOASTER is a non-for-profit foundation developing a unique technological and innovative model to support the latest challenges in microbiology. In particular, BIOASTER uses and develops high value technological innovations that accelerate development of medical solutions for populations and personalized medicine.The aim of BIOASTER is to bring together academic, industry and its capacities and specific knowledge to develop and execute high impact collaborative projects requiring industry compatible innovative technologies.Key figures:* 4 fields of expertise: antimicrobials, diagnostics, microbiota, vaccines* BSL2 & BSL3 laboratories in Lyon and Paris* 100+ employees, including 80% of scientific experts, 17 nationalities* 66+ collaborative projects, involving 27 private partners, 29 public partners.www.bioaster.org

ABOUT EVOTEC SEEvotec is a drug discovery alliance and development partnership company focused on rapidly progressing innovative product approaches with leading pharmaceutical and biotechnology companies, academics, patient advocacy groups and venture capitalists. We operate worldwide and our more than 3,300 employees provide the highest quality stand-alone and integrated drug discovery and development solutions. We cover all activities from target-to-clinic to meet the industry's need for innovation and efficiency in drug discovery and development (EVT Execute). The Company has established a unique position by assembling top-class scientific experts and integrating state-of-the-art technologies as well as substantial experience and expertise in key therapeutic areas including neuronal diseases, diabetes and complications of diabetes, pain and inflammation, oncology, infectious diseases, respiratory diseases, fibrosis, rare diseases and women's health. On this basis, Evotec has built a broad and deep pipeline of approx. 100 co-owned product opportunities at clinical, pre-clinical and discovery stages (EVT Innovate). Evotec has established multiple long-term alliances with partners including Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, CHDI, Novartis, Novo Nordisk, Pfizer, Sanofi, Takeda, UCB and others. For additional information please go to http://www.evotec.com and follow us on Twitter @Evotec.

FORWARD-LOOKING STATEMENTSInformation set forth in this press release contains forward-looking statements, which involve a number of risks and uncertainties. The forward-looking statements contained herein represent the judgement of Evotec as of the date of this press release. Such forward-looking statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in these forward-looking statements. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any such statements to reflect any change in our expectations or any change in events, conditions or circumstances on which any such statement is based.

14.09.2020 Dissemination of a Corporate News, transmitted by DGAP - a service of EQS Group AG.The issuer is solely responsible for the content of this announcement.

The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Archive at http://www.dgap.de

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EVOTEC AND BIOASTER PARTNER TO BUILD A TECHNOLOGY AND INNOVATION HUB IN LYON - PharmiWeb.com

Despite not being able to attend conferences live, there are some advantages to a virtual conference.

Personalized medicine might be a realistic target in many specialties in the next decade, including pulmonology.

Recently, in a paper presented at theEuropean Respiratory Society International Congress 2020 (ERS 2020), researchers presented data showing adiponectin and leptin were significantly different between men and women, with higher levels found in female patients.

Lars L. Andersson, PhD, Karolinska Institute, said 1 of the objectives of the study was to get closer to personalized medicine in an effort to derive what treatments could be most effective in individual patients.

Andersson explained in an interview with HCPLive, the new study gives researchers a better understanding of the impact of sex and age on circulating adipokines.

The study included 55 patients with mild to moderate asthma, 72 patients with severe asthma, and 41 patients with COPD. Overall, the researchers found both adiponectin and leptin were highly affected by body mass index (BMI), another datapoint for personalized medicine.

In a subgroup analysis, they found the difference in adiponectin between women and men was smaller in lean patients, while the difference in leptin was smaller in obese patients.

While the study was important, in a normal year Andersson would be able to present it live to his colleagues. However, with the coronavirus disease 2019 (COVID-19) pandemic bringing conferences virtual Andersson was forced to adjust.

However, Andersson said the virtual format has some benefits.

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Lars Andersson, PhD: The Future of Personalized Medicine for Asthma - MD Magazine

The proteomics market is segmented on the basis of proteomics instrumentation technology such as protein microarray (biochips, microarray instruments), spectroscopy (Mass and NMR), X-ray crystallography, chromatography, electrophoresis, proteomics reagents, proteomics services (analytical lab services, protein identification, extraction, sequencing, data analysis, maintaining bioinformatics data bases). The market is driven by growing need of personalized medicines, new discoveries in the field of genomics, rise in funds for proteomics based research, growing research and development expenditure, advancement in technologies, new techniques, high output, high resolutions achiness and instruments have been developed, availability of private funds and rise in the Asian markets like China and Japan.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

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The top 10 companies own 40 to 50 percent of the market. Proteomic instrumentation market is dominated by proteomic microarray, accounting for around 50% of the revenue followed by spectroscopy techniques. Proteomic reagents market is dominated by immunoassays.

The market is restrained by various factors such as: success ratio of the researches is not very high, limitations of personalized medicines and lengthy regulatory approval process, reduction in funds by the US government, which owes 40% of this market, highly expensive medicines, which are 1000 fold costlier than the normal medicines present in the market and research and market is limited to a few developed nations only.

Major opportunities for the market lie in the Asian markets where contract research organizations are on a rise. Proteomics is science with broad applications in the field of therapeutics and diagnostics. Growing R&D and emergence of new players will create more market opportunities. Major players in the proteomics market are Thermo Fischer scientific corporation, Agilent technologies, Luminex corporation, Sigma-Aldrich corporation, Danaher corporation, Bio-Rad corporation, Waters corporation, PerkinElmer, Affymetrix and others.

The Final Report will cover the impact analysis of COVID-19 on this industry (Global and Regional Market).

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Companies profiled

1. Genzyme Corporation2. Thermo Fischer scientific corporation3. Becton Dickinson and Co4. BG medicine5. Agilent technologies6. Luminex corporation7. Sigma-Aldrich corporation8. Danaher corporation9. Anaspec Inc10. Asterand PLC11. Applied biosystems Inc12. Bayer technology13. Bio-Rad corporation14. Waters corporation15. PerkinElmer16. Affymetrix17. GE healthcare18. Genesystems Inc19. Activx Biosciences Inc20. Amgen Inc21. Beckman coulter22. Biacore International AB23. Biocarta Inc24. Bruker biosciences25. Caliper Lifesciences26. Cellzome AG27. Commonwealth biotechnologies28. Digilab biovision GmBH29. Dionex Corp30. Dualsystems biotech AG

This Research Report covers

1. Historical data2. Revenue forecasts, growth rates and CAGR upto 20283. Industry Analysis4. Competitive Analysis5. Key geographic growth data6. In-depth profiling of companies

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Kenneth Research provides market research reports to different individuals, industries, associations, and organizations with the aim of helping them to take prominent decisions. Our research library comprises more than 10,000 research reports provided by more than 15 market research publishers across different industries. Our collection of market research solutions covers both the macro level as well as micro-level categories with relevant and suitable market research titles. As a global market research reselling firm, Kenneth Research provides a significant analysis of various markets with pure business intelligence and consulting services on different industries across the globe. In addition to that, our internal research team always keeps a track of the international and domestic market for any economic changes impacting the products demand, growth, and opportunities for new and existing players.

Updated Research Report Available @Kenneth Research with impact analysis of COVID-19

Geospatial Imagery Analytics MarketNetwork Access Control MarketVisitor Management System MarketPenetration Testing MarketPower Distribution Unit (PDU) Market

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Impact Analysis of COVID-19 on Proteomics Market Outlook 2020-2028 by Emerging Global Trends, Leading Companies, Future Growth, Revenue, and Demand...

The global cell surface markers market is valued at an estimated USD 520 million in 2018 and is projected to reach USD 769 million by 2023, at a CAGR of 8.1%

Factors such as the increasing funding for life sciences research, high global prevalence of cancer, and growth in stem cell and neurobiology research are expected to drive the growth of this market in the coming years.

[140 Pages Report] The cell surface markers market is valued at an estimated USD 520 million in 2018 and is projected to reach USD 769 million by 2023, at a CAGR of 8.1% during the forecast period.

Cell Surface Markers Market by Product (Antibody, PCR Array), Source (Mice, Rat), Cell Type (T cells, B cells, NK cell), Application (Research (Stem Cell, Immunology), Clinical (Oncology, Hematology)), and End User (Hospitals) - Global Forecast to 2023

What drives the Market?

The increasing number of R&D activities and the growing use of cell surface markers in personalized medicine and drug discovery & development.

Download a PDF Brochure @ http://www.marketsandmarkets.com/pdfdown=216278622

North America is expected to be the largest regional market for cell surface markers

Market growth in North America, the largest regional market for cell surface markers, is primarily driven by the increasing number of R&D activities and the growing use of cell surface markers in personalized medicine and drug discovery & development. However, the market in Asia is estimated to grow at the highest CAGR during the forecast period.

The high growth of the Asian market can be attributed to the increasing number of life sciences research activities and government initiatives to boost the biotechnology and pharmaceutical industries in several Asian countries.

Key Market Players

The cell surface markers market is highly fragmented in nature, with several big as well as emerging players. Prominent players in this market include Thermo Fisher Scientific (US), QIAGEN N.V.

(Netherlands), Becton, Dickinson and Company (US), F. Hoffman-La Roche (Switzerland), Bio-Rad Laboratories (US), Danaher Corporation (US), Abcam (UK), GenScript (China), BioLegend (US), Cell Signaling Technology (US), Merck KGaA (Germany), and Bio-Techne (US).

Abcam is one of the prominent players operating in the cell surface markers market. The strong position of the company in this market can be attributed to its robust product portfolio.

The company has a strong geographical presence in the European and Asia Pacific markets with its manufacturing facilities in the UK, Japan, and China. The company also has significant market presence in the US and Latin America.

Thermo Fisher Scientific is another leading player in the cell surface markers market. The companys strong brand recognition and extensive product portfolio in this market are its key strengths.

To maintain its leading position in the market, the company adopts organic as well as inorganic growth strategies such as acquisitions and expansions.

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North America is expected to be the largest regional market for Cell Surface Markers - WhaTech

Global microbiome sequencing marketis expected to rise to an estimated value of USD 3455.33 million by 2026, registering a healthy CAGR in the forecast period of 2019-2026. This rise in market value can be attributed to the focus of various researchers on utilization of this technology in the development of personalized medicine and dietary applications.

For the growth of any business, Microbiome Sequencing market research report plays a very important role. You can get an in-depth market analysis with this report to thrive in this competitive environment. Microbiome Sequencing market report is sure to lend a hand in enhancing sales and improving return on investment (ROI). Estimations of CAGR values, market drivers and market restraints helps businesses decide upon several strategies. DBMR team provides you the Microbiome Sequencing market research report with commitment that is promising and the way in which you anticipate. As it is a third-party report, Microbiome Sequencing report is more unprejudiced and hence provides a better picture of what is really happening in the market.

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Few of the major competitors currently working in the global microbiome sequencing market areBIOLOG; Cosmosid Inc; Illumina, Inc.; Metabiomics Corp.; Oxford Nanopore Technologies; BaseClear B.V.; BGI; BioMathematica; Charles River; CoreBiome, Inc.; Clinical-Microbiomics A/S; Diversigen; Eurofins Scientific; LABCYTE INC.; Leucine Rich Bio Pvt Ltd.; Microbiome Insights; MICROBIOME THERAPEUTICS, LLC; Thermo Fisher Scientific Inc.; Molzym GmbH & Co. KG; Norgen Biotek Corp.; Phase Genomics Inc.; QIAGEN; Resphera Biosciences, LLC; Shoreline Biome; StarSEQ GmbH; Viome, Inc.; Zymo Research among others.

Key Developments in the Market:

Market Drivers

Market Restraints

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Segmentation: Global Microbiome Sequencing Market

By Sequencing Technology

By Component

By Targeted Disease

By Application

By Research Type

By End-User

By Laboratory Type

ByGeography

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Global Microbiome Sequencing Market By 2027 Emerging Technology, Opportunities, Analysis And Future Threats With Key Players Like Oxford Nanopore...

Neurological Biomarkers Market Research Report is a Proficient and In-Depth Study on the Existing State of Neurological Biomarkers Industry. This Report Focuses on the Major Drivers, Restraints, Opportunities and Threats for Key Players. It also Provides Granular Analysis of Market Share, Segmentation, Revenue Forecasts and Regional Analysis till 2025.

The recent study on Neurological Biomarkers market offers an all-inclusive analysis of this vertical, with emphasis on the growth driving factors as well as facets such as consumption and production. Constraints and potential threats expected to restrain the expansion along with solutions to overcome the challenges are discussed at length. Moreover, insights of the market share along with estimates reflecting the CAGRs of the listed segments are highlighted in the document.

In hindsight of the COVID-19 pandemic, the report investigates the prevalent business strategies employed by leading organizations and offers tactics for stakeholders to adapt to the industry changes over the forecast period.

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Neurological Biomarkers Market Structure, Industry Inspection, and Forecast 202 - News by aeresearch

While identifying new genetic targets and developing novel drugs is important for the future of non-small cell lung cancer (NSCLC), more emphasis should be put on improving patient access to existing targeted treatments, according to Dr. Nathan A. Pennell.

In an interview with OncLive, CUREs sister publication, Pennell, an associate professor in thedepartment of medicine and director of the lung cancer medical oncology program at theTaussig Cancer Institute of Cleveland Clinic,spoke about current and emerging treatment options in NSCLC, including immunotherapy combinations and personalized treatments involving T cells.

But when it comes to the future, Pennell said, identifying targetable genetic alterations in patients and treating them with existing drugs should be a key area of focus.

Studies have shown that probably fewer than half of people with targetable genetic alterations in lung cancer are being identified and never receiving treatment for this, Pennell said, and I think before we move on to the next exciting drug or the next exciting marker, we should spend a little time making sure that every patient is identified and gets access to the treatments that we already have.

Transcription:

We've made such tremendous progress over the last decade. And just it seems like every year, new targets are emerging and new drugs are getting approved. And so, the speed with which we're moving from discovery to actually treating people has been staggering, and I hope that continues.

There continue to be very promising emerging biomarkers including KRAS mutations, again, HER2 mutations. There certainly is lots of room for improving the efficacy of immunotherapy, which can be tremendously life changing and potentially even curative in patients with metastatic disease. But unfortunately, it's only really working in a minority of patients and so lots of room to be improved in that.

I think combinations of immunotherapy and perhaps even more personalized immunotherapy, using T-cells that recognize individual patients tumors, may be the future for this, or personalized tumor vaccines.

But honestly, instead of just focusing on discovering new treatments and new targets, I think we should focus more on applying what we already know. So, we have tremendous treatments for patients with specific subgroups of lung cancer, but studies have shown that probably fewer than half of people with targetable genetic alterations in lung cancer are being identified and never receiving treatment for this. And I think before we move on to the next exciting drug or the next exciting marker, we should spend a little time making sure that every patient is identified and gets access to the treatments that we already have.

Link:
Personalized Medicine, Genetic Testing Could Shape the Future of Non-Small Cell Lung Cancer - Curetoday.com

3D printing or additive manufacturing has opened a new avenue in the personalized patient care. It is still a relatively emerging technology in the global healthcare industry. The market has seen vast potential in technologies that help surgeons and clinicians understand the complexity of the geometry of human organs and offer timely treatment. 3D printing is rising in clinical significance in printing organs that would be transplanted to the diseased populations, should other options be uncertain or exorbitantly costly. 3D-printed implantable organs will no longer be novelty but a necessity, paving way for lucrativeness of the healthcare 3D printing market. Another area where 3D printing is being utilized is printing of drugs and devices by pharmaceutical and medical companies, world over. The increasing trend of precision medicine and personalized treatments has fuelled the evolution of the healthcare 3D printing market.

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3D printing technology has helped clinician advance their patient care. New additive manufacturing technologies have acted as key accelerators of patient-specific model. Particularly, healthcare 3D printing will expand the armamentarium for surgeons to substantially expand their knowledge of patient specific anatomy of crucial lungs such as heart and lungs. The growing availability and affordability of 3D printing techniques will help carve out new avenues in the market. Advances in raw materials used, notably in hydrogel, has also catalyzed prospects in the healthcare 3D printing market. Researchers over the past few years have aimed at changing the consistency of 3D printing materials to make them more biologically adaptable as well as functional. This has also helped them to commercialize the printing process. The increasing shift to patient-specific care will increase the use cases of healthcare 3D printing around the world. New 3D printing technologies will pave way to transforming patient-provider relationship in the not-so-distant future. The use of implantable custom devices is a case in point.

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Global Healthcare 3D Printing Market: Overview

The global market for healthcare 3D printing has been rising on account of advancements in the field of medical research, testing, and analysis. 3D printing helps in developing archetypes and blueprints for objects and items, and this technique plays a key role in multiple industries. The use of 3D printing in the field of healthcare has overhauled the growth dynamics of the worldwide healthcare industry. 3D printing helps in development of organ simulations for testing, research, and analysis. Furthermore, the field of medical testing has also gained a strong impetus on account of advancements in the field of healthcare 3D printing. Considering these dynamics, it is safe to ascertain that the global healthcare 3D printing market would grow at a sound pace in the times to follow. The healthcare industry has emerged as the central element in determining the growth dynamics of a regional territory. This is another key driver of demand within the global market for healthcare 3D printing. Improved technologies for 3D printing shall persuade the healthcare fraternity to resort to its usage in the years to come.

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The global healthcare 3D printing can be segmented on the basis of the following parameters: North America, Latin America, the Middle East and Africa, Europe, and Asia Pacific. The growth of the global healthcare 3D printing can be gauged with the help of the aforementioned segments.

A report added by Transparency Market Research (TMR) on the global healthcare 3D printing market is a holistic description of the forces of demand and supply. The report sheds light on the influence of various external forces on the global healthcare 3D printing market. Moreover, the regional segments within the global healthcare 3D printing market have also been enunciated therein. A list of the leading companies in the global healthcare 3D printing is also a part of the report.

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Global Healthcare 3D Printing Market: Trends and Opportunities

The presence of a stellar healthcare sector that focuses on development of models and archetypes for analysis and research has aided market growth. 3D printing helps in training of medical professionals and doctors with the help of simulated models of body parts. This factor has led to the increased usage of healthcare 3D printing across the world.3D printing also helps in performing knee and hip implants which is another key driver of demand within the global healthcare 3D printing market. There is little contention about the inflow of massive revenues in the global healthcare 3D printing market.

Global Healthcare 3D Printing Market: Market Potential

The global healthcare 3D printing market has generated a plethora of opportunities for improved research and testing within medicine. This factor has had a direct impact on the growth of the global healthcare 3D printing market. Furthermore, the need to develop close archetypes of key body parts such as lungs, heart, and spine has also generated demand within the global healthcare 3D market.

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Global Healthcare 3D Market: Regional Outlook

On the basis of geography, the global healthcare 3D printing market can be segmented into North America, Latin America, the Middle East and Africa, Europe, and Asia Pacific. The market for healthcare 3D printing in North America is projected to grow on account of advancements in the field of medical research and testing.

Global Healthcare 3D Market: Competitive Landscape

Some of the key vendors in the global healthcare 3D printing market are Bio-Rad Laboratories, SOLS, Organovo, Simbionix, RegenHU Ltd.,and Metamason.

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Healthcare 3D Printing Market: Increasing trend of precision medicine and personalized treatments has fuelled the evolution of the market - BioSpace

Personalized and precision medicines are exciting fields that focus on the development of treatment and prevention strategies for a single patient or patient group. The treatments are developed using cutting- edge technologies such as genomic sequencing and genetic engineering, helping to account for the individual variability in both patient and disease characteristics.

This has gained a lot of attention in recent years due to revolutionary breakthroughs in debilitating chronic diseases such as cancer. Traditionally, cancer patients are treated using one size fits all interventions like chemotherapy, radiotherapy and surgery. These vary in their effectiveness and result in damage to healthy tissues.

Personalized and precision medicine, however, can offer specialized treatments that target the patients unique cancer subtype, its genetic mutations, and the affected tissues.

These therapies involve novel pathways and complex processes to aid and deliver treatment, making each therapy a service in its own right. They depend on many touchpoints, stakeholders, partnerships and interdependencies to treat patients.

As a result, designing suitable services to support patients, caregivers and healthcare providers throughout the treatment pathway is essential. However, doing so successfully depends on understanding how to best approach the design of services in this challenging landscape.

Optimizing the service behind the personalized and precision medicine is crucial for turning the treatment into a viable and differentiated option for patients. To make a real difference and ensure the therapy is competitive, we need to adopt a service design approach.

Service design is a multidisciplinary art and science that enables us to take a holistic view of the service experience, along with a deep understanding of the target groups, such as patients and healthcare professionals, and the context they operate in. This can include using empathic methodologies, such as in-depth interviews and field studies.

Gaining a comprehensive understanding of the customers needs, how they experience the current service, and how future services address their unmet needs.

Involving different stakeholders throughout the design process to gain a wide range of knowledge and expertise, and to further drive customer-centricity across the business.

Using visual tools such as sketches, maps and prototypes to improve and ease communication and collaboration between the different stakeholders involved in the creative process (surpassing language and knowledge boundaries).

Following a learning-by-doing approach via continuous prototyping and testing to evaluate solutions before investing time and resources on development.

Understanding how the customer experiences the whole service journey and then identifying insight gaps and opportunities for service innovation by looking at the big picture.

Personalized and precision medicines are naturally patient-centered (compared to traditional pharmaceuticals), as the individual patient is central to the product design. Taking this empathic approach throughout the design process provides a deeper understanding of those needs as well as their context.

This means not only adopting collaborative thinking during the design phase but also during production and development.

To deliver these unique therapies to patients, pharmaceutical companies must partner with a wide range of specialized third parties including laboratories, manufacturers, shipping and storing providers.

Looking at the entire service and all of its touchpoints from above is crucial

By engaging with multidisciplinary teams from all levels across the organization, as well as numerous stakeholders during the co-creation process, you will increase the organizations knowledge and expertise, resulting in better and more fit-for-purpose solutions. Bring this sense of collaboration into the design process to encourage a higher level of consistency, placement and commitment to the patient and ensure they are at the center of the service philosophy.

Novel therapies require designers to be adaptive. New developments such as changes in the supply chain, shorter genomic sequencing process or the need for an additional quality assurance step, often lead to changes to the envisaged treatment pathway. As a result, it is necessary to have a view of the whole service, in one place, which can be continuously updated.

Visual tools such as customer journey maps and service blueprints are a core part of service design. Journey maps (such as the one featured on p.16) provide an overarching view of the customer experience, along with the pain points, gaps, unmet needs and opportunities for engagement. Service blueprints visualize the process behind the service and the people impacted by it. These tools not only make it easier to understand the service, but they can also help simplify communication and increase alignment between the many individuals engaged in the project.

For personalized and precision medicines, patient journeys and service blueprints can help capture the front-end of the service, which is visible to patients, and the back-end processes, which are used by healthcare professionals. This gives us insights into the interactions, touchpoints and relationships between the patient and various stakeholders, such as the different healthcare professionals, carers and patient groups. Looking at the entire service and all of its touchpoints from above is crucial for making improvements that enrich the customer experience.

CAR-T is a new individualized cancer immunotherapy that has taken precision medicine to a new level. In a nutshell, CAR-T therapy involves extracting T-cells (a type of white blood cells that play a key role in immune response) from the patient, genetically engineering them to target the cancer cells and infusing them back into the patients body.

The CAR-T treatment pathway for a blood cancer involves a uniquely large number of stakeholders, touchpoints and interdependent processes that take place both in the front-end (i.e. visible to the patient) and back-end (i.e. visible to healthcare professionals). Below is a high- level overview of a typical CAR-T journey that can illustrate this complexity:

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In the precision medicine era, the line between products and services is blurred - - pharmaphorum

DENVER--(BUSINESS WIRE)--Today ClinOne announced a strategic partnership with CQuentia to bring focused and personalized molecular testing to clinical trial patients. ClinOnes mission is to simplify and accelerate clinical trials for those conducting, participating in and benefiting from clinical studies in onsite, remote, and strictly virtual settings. Our goal is to increase patient access to life changing clinical trials, while continually analyzing operations and developing workflows and capabilities to minimize our clients costs, explains Rob Bohacs, ClinOnes CEO. Partnering with a laboratory such as CQuentia, provides a depth of diagnostic testing that expands ClinOnes offering and brings comprehensive lab solutions directly to the patients.

ClinOne continuously evaluates the market for innovative companies and products to add to its suite of e-clinical technologies. CQuentia is a thought leader in genomic testing and a natural fit, given their comprehensive COVID-19 testing capabilities offered at or near patients homes, explains Dr. Elizabeth Esterl, ClinOnes VP of Operations and Research.

CQuentia is a next-generation sequencing FDA CLIA laboratory and data service that brings a sophisticated precision medicine platform to ClinOnes suite of resources. Among the tests conducted by CQuentia and made available through ClinOne are COVID-19 RT-PCR and Antibody tests, Respiratory Pathogen Panel (RPP) and Pharmacogenomic testing (PGx). CQuentias testing improves the overall well-being of patients by reducing risk and enhancing safety protocols. Esterl explains that such actionable and customized clinical information aligns with our clients to expand virtual clinical trials, by enhancing screening, increasing enrollment and keeping participants actively engaged throughout the trial period.

What separates CQuentia from other testing laboratories is our platform agnostic approach to deliver solutions and our ability to create personalize client specific reports and alerts which plays to ClinOnes strengths and uniqueness as they bring mission-critical clinical study details to clients, research sites and patients. We are motivated by the change we can make in peoples lives through this collaboration, explains Alan Meeker, CQuentia CEO.

About ClinOne

ClinOne is a suite of technologies created to improve access to mission-critical clinical study details, manage research site workflow, and provide patients with a solution to manage the clinical trial journey. The companys sole mission is to simplify and accelerate clinical trials through a single, unified central clinical trial operating system between sponsors, research sites and patients. Today, 45 global sponsors and 2,000 research institutions across 55 countries rely on ClinOnes technology. For more information visit http://www.clinone.com.

About CQuentia

CQuentia is a privately-held molecular testing and sequencing laboratory, positioned to provide doctors, governments, hospitals, payers and employers with rapid, reliable results. CQuentia provides precision medicine, data banking and infection identification, thus enabling clients to make informed clinical decisions, improve outcomes and deliver overall value throughout the healthcare continuum. For more information please visit http://www.cquentia.com

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ClinOne Partners with CQuentia to Add COVID-19 and Comprehensive Precision Medicine Testing to Their Suite of Clinical Trial Operating Services and...

New Jersey, United States, The Personalized Medicine Market report 2020 provides a detailed impression, describe the product industry scope and the market expanded insights and forecasts up to 2027. It shows market data according to industry drivers, restraints and opportunities, analyzes the market status, the industry share, size, future Trends and growth rate of the market. The Personalized Medicine Market report is categorized by application, end user, technology, product / service types, and other, as well as by region. In addition, the report includes the calculated expected CAGR of chitosan acetate-market derivative from the earlier records of the Personalized Medicine Market, and current market trends, which are organized with future developments.

Personalized Medicine Market was valued at USD 96.97 Billion in 2018 and is expected to witness a growth of10.67% from 2019-2026 and reachUSD 217.90 Billion by 2026.

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The report provides detailed coverage of the Personalized Medicine Market, including structure, definitions, applications, and Industry Chain classifications. The Personalized Medicine Market analysis is provided for the international markets including development trends, competitive landscape analysis, investment plan, business strategy, opportunities and development status of key regions. Development policies and plans are discussed and manufacturing processes and cost structures analyzed. This report also includes information on import / export consumption, supply and demand, costs, industry share, policy, Price, Sales and gross margins.

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Personalized Medicine Market forecast up to 2027, with information such as company profiles, product picture and specification, capacity production, price, cost, revenue, and contact information. Upstream raw materials and equipment as well as downstream demand analyses are also carried out. The Personalized Medicine Market size, development trends and marketing channels are analyzed. Finally, the feasibility of new investment projects is assessed and general research results are offered.

The Personalized Medicine Market was created on the basis of an in-depth market analysis with contributions from industry experts. The report covers the growth prospects in the coming years and the discussion of the main providers.

To understand how the effects of COVID-19 are addressed in this report. A sample copy of the report is available at https://www.verifiedmarketresearch.com/product/global-personalized-medicine-market-size-and-forecast-to-2026/?utm_source=TDC&utm_medium=001

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Personalized Medicine Market is Thriving Worldwide 2020 | Trends, Growth and Profit Analysis, Forecast by 2027 - The Daily Chronicle

IRVING, Texas, Sept. 9, 2020 /PRNewswire/ --Caris Life Sciences, a leading innovator in molecular science focused on fulfilling the promise of precision medicine, announced today that Brian J. Brille, Vice Chairman of the Company, will participate in a fireside chat at the 18th Annual Morgan Stanley Global Healthcare Conference Thursday, Sept. 17, 2020, at 9:30 a.m. Eastern time.

Mr. Brille will provide an overview of Caris' business, along with its suite of market-leading molecular profiling offerings, and discuss recent corporate growth initiatives that position Caris to further extend its leadership reach in the market. Thomas Parker, Senior Vice President and Chief Financial Officer at Caris, will be available for Q&A.

Attendees who would like to schedule a one-on-one meeting with Caris executives may do so by contacting their Morgan Stanley representative.

About Caris Life SciencesCaris Life Sciences is a leading innovator in molecular science focused on fulfilling the promise of precision medicine through quality and innovation. The company's suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions. MI Exome whole exome sequencing with 22,000 DNA genes, and MI Transcriptome whole transcriptome sequencing with 22,000 RNA genes along with cancer-related pathogens, bacteria, viruses and fungi analysis run on every patient provides the most comprehensive and clinically relevant DNA and RNA profiling available on the market.

Caris is also advancing precision medicine with Caris MAI (Molecular Artificial Intelligence) that combines its innovative service offerings, Caris Molecular Intelligence with its proprietary artificial intelligence analytics engine, DEAN, to analyze the whole exome, whole transcriptome and complete cancer proteome. This information, coupled with mature clinical outcomes on thousands of patients, provides unmatched molecular solutions for patients, physicians, payers and biopharmaceutical organizations.

Caris Pharmatech is changing the paradigm and streamlines the clinical trial process by assisting biopharma companies with accessing research-ready oncology sites for clinical trials. With over 200 research sites within the Caris Pharmatech JIT Oncology Network, biopharma companies can identify and enroll more patients, faster. Caris Pharmatech Just-In-Time Clinical Trial Solutions focus on rapid site activation and patient enrollment to streamline the drug development process. By implementing a Just-In-Time (JIT) Research System, site activation and patient enrollment is achievable within 14 days for pre-registered locations with pre-qualified patients.

Headquartered in Irving, Texas, Caris Life Sciences has offices in Phoenix, Denver, New York, and Basel, Switzerland. Caris provides services throughout the U.S., Europe, Asia and other international markets. To learn more, please visitwww.CarisLifeSciences.comor follow us on Twitter (@CarisLS).

Investor Inquiries:Argot Partners [emailprotected]212-600-1902

Media Contact: Lindsey BailysGCI Health[emailprotected]212-798-9884

SOURCE Caris Life Sciences

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Caris Life Sciences Announces Participation in the 18th Annual Morgan Stanley Global Healthcare Conference - PRNewswire

SAN FRANCISCO, Sept. 08, 2020 (GLOBE NEWSWIRE) -- Latest study released by Data Bridge Market Research on Pharma Clinical Trial Digitization Market research report 2020 comprises of several parameters which are thoroughly studied by the experts. This market report contains fundamental, secondary and advanced information related to the global status and trend, market size, sales volume, market share, growth, future trends analysis, segment and forecasts from 2020-2027. This market study considers a market attractiveness analysis, where each segment is benchmarked based on its market size, growth rate, and general attractiveness. All the data and statistics provided in this Pharma Clinical Trial Digitization Market report are backed up by latest and proven tools and techniques such as SWOT analysis and Porter's Five Forces Analysis.

Pharma clinical trial digitizationmarket is expected to gain market growth in the forecast period of 2020 to 2027. Data Bridge Market Research analyses the market to grow at a CAGR of 5.7% in the above-mentioned forecast period. Growing demand for personalized medicine is expected to create new opportunity for the pharma clinical trial digitization market.

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According to this report Global Pharma Clinical Trial Digitization Market will rise from Covid-19 crisis at moderate growth rate during 2020 to 2027. Pharma Clinical Trial Digitization Market includes comprehensive information derived from depth study on Pharma Clinical Trial Digitization Industry historical and forecast market data. Global Pharma Clinical Trial Digitization Market Size to Expand moderately as the new developments in Pharma Clinical Trial Digitization and Impact of COVID19 over the forecast period 2020 to 2027.

In the Pharma Clinical Trial Digitization Market report, market drivers and market restraints are studied carefully along with the analysis of the market structure. This market research report is an ideal guide to attain information or key data about market, emerging trends, product usage, motivating factors for customers, competitor strategies, brand positioning, customer preferences, and customer behaviour. While generating this Pharma Clinical Trial Digitization Market research report, customer satisfaction is kept on the utmost priority. To thrive in this competitive market place, market research report plays a vital role which gives important and meaningful market insights for the business.

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Top key players covered in the pharma clinical trial digitization market report are:

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Clinical trial digitization allows the processing in different forms of voluminous patient-related data. Such data are being used by pharmaceutical companies to improve the effectiveness of trial execution.

Growing demand for quality data is expected to drive the market growth. Some of the other factors such as increasing demand for personalized drugs, increasing adoption of new technology in clinical research, growing research & development promoting outsourcing and increasing diseases prevalence will drive the market in the forecast period of 2020 to 2027

How Does This Market Insights Help?

Pharma Clinical Trial Digitization Market share (regional, product, application, end-user) both in terms of volume and revenue along with CAGR

Key parameters which are driving this market and restraining its growth

What all challenges manufacturers will face as well as new opportunities and threats faced by them

Learn about the market strategies that are being adopted by your competitors and leading organizations

To gain insightful analyses of the market and have a comprehensive understanding of the Pharma Clinical Trial Digitization Market and its commercial landscape

Key Pointers Covered in the Pharma Clinical Trial Digitization Market Industry Trends and Forecast to 2027

Pharma Clinical Trial Digitization Market Scope

The pharma clinical trial digitization market is segmented on the basis of countries into U.S., Canada and Mexico in North America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Rest of Europe in Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), Brazil, Argentina and Rest of South America as part of South America.

All country based analysis of pharma clinical trial digitization market is further analyzed based on maximum granularity into further segmentation. On the basis of services, the pharma clinical trial digitization market is segmented into drug dose adjustment, drug impact monitoring, medical prescription system, bioprinting, preventive therapy, and individualized drug printing. Based on application, the market is segmented into clinical data management, trial monitoring, patient recruitment and enrollment. The pharma clinical trial digitization market on the basis of theme is segmented into digital continuity across clinical trial IT systems, patient-centric remote and virtual trial design and direct-to-patient home services.

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Competitive Landscape

Pharma clinical trial digitization market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, global presence, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, application dominance. The above data points provided are only related to the companies focus related to pharma clinical trial digitization market.

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Table of Contents: Global Pharma Clinical Trial Digitization Market

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Pharma Clinical Trial Digitization Market: 2020 Global Segment Analysis (Services, Application, Themes, Country), Future Trend Rising at +5.70% CAGR...

MOH approves Cocoon Platform to manufacture a CD19 CAR-T cell immunotherapy for Phase II clinical trial for B-cell malignancies.

Contract Pharma Staff09.09.20

Lonza and Sheba Medical Center announced the first patient has been treated at Sheba Medical Center with a CD19 CAR-T cell immunotherapy manufactured using Lonzas Cocoon Platform. The Cocoon Platform is an automated and functionally closed system for patient-scale cell therapy manufacturing, designed to overcome some of the manufacturing challenges of manually producing personalized medicines, including autologous CAR-T cell therapies.

Sheba Medical Center and Lonza have collaborated to translate Shebas open, manual manufacturing process into the Cocoon Platform since mid-2019. Teams from Lonza Personalized Medicine and Collaborative Innovation Center (CIC) in Haifa, IL worked closely with Sheba Medical Center to complete process development, tech transfer, training and a full clinical comparability study requiring regulatory approval before the first patient could be treated. The approval of the Cocoon Platform clinical comparability study illustrates the platforms flexibility and ability to manufacture a final cell immunotherapy which is comparable to the original manual process while meeting the extensive patient safety criteria.

Sheba and Lonza plan to treat additional patients under the same CD19 CAR-T cell immunotherapy protocol using the Cocoon Platform. The Cocoon Platform will enable Sheba to reduce immunotherapy manufacturing costs by lowering manpower, time, and space requirements. The goal is to ultimately allow Sheba to deliver potentially curative cellular immunotherapies to more patients.

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CD19 CAR-T Therapy Manufactured Using Lonza's Cocoon Platform - Contract Pharma

New York, Sept. 08, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Wearable Electronics Industry" - https://www.reportlinker.com/p03180729/?utm_source=GNW After smartphones and tablets, smart wearables is the new innovation taking the technology to a fevered pitch in the consumer electronics industry. These tiny devices hold the potential to replace smartphones, make the many benefits of digital health real and achievable, enable the rise of hyper-connected interactive enterprises, and make clothing smart, fashionable, functional and comfortable. Benefits of wearables devices include lightweight, extreme portability, durable, easily transportable, convenience, ease-of-use and comfort. Smartwatch is the most popular form and dominant factor for wearables. Other evolving new designs include smart glasses, goggles, bracelets, armbands, necklaces, lanyards, pins, clips, headbands, headsets, belts, shoes, shirts, Jackets and pants, among others. The biggest area of impact in electronic wearables is in the healthcare industry. Medical grade wearables are poised to create a revolution in personalized digital healthcare. Wearables will enable telehealth via remote patient monitoring (RPM) capabilities making healthcare services more efficient, self-determined and cost efficient. Opportunities in this space are immense as the current healthcare system seeks to utilize telehealth to advance value based care goals. A key benefit of telehealth is its ability to drive positive patient experience and eliminate access barriers to offer patient-centric and convenient care. Wearables will also play a key role in precision medicine by providing physicians better knowledge of patients health. Integration of sensors such as physiological sensors and biochemical sensors will provide continuous monitoring of a patients vital signs and timely clinical decisions can be taken such as therapy modifications based on subtle changes observed in health patterns.

From simple biophysical/ biochemical monitoring (BP & diabetes), continuous innovation will expand applications to more advanced continuous arrhythmia detection and monitoring blood pulse signals from human femoral, carotid and radial arteries. Another exciting area of innovation is the integration of artificial intelligence (AI) enabled Healthbot applications in smartwatches designed to help patients with disease/therapy management and counselling. Healthbots have the potential to expand the outreach of healthcare services especially in countries and regions where doctor to patient ratio is low thus creating a bottleneck in accessing primary care services. In the addition to healthcare, clothing also represents and emerging area of opportunity for wearables. Innovative development of flexible, transparent graphene electrodes and their integration into commonly used textile fibers will be the first step forward in revolutionizing e-textiles. Significant R&D resources are therefore being sunk into developing processes and engineering techniques to integrate graphene in textiles as it hold the key that will unlock a new universe of commercial application opportunities in the coming years. The United States and Europe represent large markets worldwide with a combined share of 67.9% of the market. China ranks as the fastest growing market with a CAGR of 28.4% over the analysis period supported by the fact that the country leads the world in digital health adoption.

Read the full report: https://www.reportlinker.com/p03180729/?utm_source=GNW

I. INTRODUCTION, METHODOLOGY & REPORT SCOPE

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW Wearable Technology: The Transition from Science Fiction to Reality Historical Journey of Wearable Technology Applications & Solutions of Wearable Electronics Wearable Electronics Market: Expanding Applications of Miniaturized, High Performance Wearable Devices Boosts Prospects Wrist-Wear Dominates Global Wearable Electronics Market Consumer Electronics: The Largest End-Use Market Developed Regions Lead, Developing Regions at the Forefront of Future Growth Global Competitor Market Shares Wearable Electronics Competitor Market Share Scenario Worldwide (in %): 2019 Impact of Covid-19 and a Looming Global Recession

2. FOCUS ON SELECT PLAYERS Apple, Inc. (USA) Bose Corporation (USA) Epson America, Inc. (USA) Fitbit, Inc. (USA) Garmin Ltd. (USA) Huawei Technologies Co., Ltd. (China) Infineon Technologies AG (Germany) LG Electronics, Inc. (South Korea) Lifesense Group B.V. (The Netherlands) Lumus Ltd. (Israel) Misfit, Inc. (USA) Qualcomm Technologies, Inc. (USA) ReSound (Denmark) Samsung Electronics Co., Ltd. (South Korea) Shimmer Research, Inc. (Ireland) Sony Corporation (Japan) Texas Instruments, Inc. (USA) Titan Industries Ltd. (India) Vuzix Corporation (USA) Xiaomi Corporation (China)

3. MARKET TRENDS & DRIVERS Expanding Internet Connectivity and Growing Consumer Demand for Advanced Wearable Devices Fuels Market Prospects Rapid Increase in Penetration Rate of Internet: 2018 Vs. 2009 Rising Number of IoT and Connected Devices Drive Growth in Wearable Electronics Market World IoT Market: Number of Connected Devices (in Million) for Years 2016, 2018E, 2020P and 2022P Market Share Scenario of Connected Devices in Global Internet of Things (IoT) by Geographic Region: 2019 & 2024 Growing Prominence of Wearable Tech in Healthcare Propels Market Growth Global Digital Healthcare Opportunity (in US$ Billion) for the Years 2017, 2019, 2022, 2024 and 2026 Chronic Diseases Management: A Key Focus Area Need for Continuous Monitoring of Elderly Patients as Part of Chronic Disease Management Drives Growth: Number of People Aged 65+ Years in Million by Geographic Region for the Years 2019 and 2030 Rising Consumer Awareness about Health & Fitness Spells Growth for Wearables Potential Role for Wearable Electronics in Patient Monitoring and Tracking Systems Smart Clothing Gains Acceptance in Neonatal Monitoring Wearables Technology Makes Diabetes Manageable Rising Diabetes Prevalence Presents Opportunity for Wearable Electronics Market: Number of Adults (20-79) with Diabetes (in Millions) by Region for 2019 and 2045 ECG Monitoring Wearables: A Promising Area of Growth Increasing Significance of Wearables in Pain Management Wearable Sleep Monitoring Technology Wearable EEG Monitors Smart Medical Textile Garments: An Emerging Area of Interest Wrist Wear: A Revolutionary Wearable Phenomenon Fuels Growth Hybrid Smartwatch Sales Drive Market Growth Smart Glasses for Multiple Industry Applications With Wearable Computing Gaining Mainstream Attention, the Time is Ripe for Mobility in the Realm of Augmented Reality Growing Technology & Commercialization Activity Surrounding AR to Benefit Development of Smart AR Glasses: Global Market for Augmented Reality Hardware, Software & Applications (in US$ Million) for the Years 2015, 2018 & 2022 Global % Share Breakdown of Wearable AR Devices in the Market by Form Factor (2019) Activity Trackers to Lead Growth in Wearable Sports and Fitness Devices Market A Comparative Review of Popular Fitness Trackers Increasing Obesity Levels Underpin Market Growth Global Obesity Epidemic: Percentage of Overweight, Obese, and Severely Obese Adults for 2014 & 2025 Smart Clothing Transforming the Wearable Technology Products Market Smart Fabrics: The Next Big Wave of Wearables Novel Opportunities for Smart Fabrics across Various Sectors Healthcare Transportation Sports & Fitness Workwear Microencapsulation & Nanotechnologies: Harbingers of Future Growth Hearables, the Smart Headphones, Come to the Fore Increasing Popularity of Wearables in Infotainment & Gaming Industry Enterprise Applications of Wearables Present Growth Potential for Wearable Electronics Market Wearable Technology Boosts CRM Rising Adoption of Wearable Technology in Industrial Sector Drives Growth Cloud Computing Drives the Momentum in Wearable Electronics Market Combination of AI and Wearable Technology Transforms the Wearable Electronics Market Global Market for Wearable AI in US$ Billion for the Years 2018, 2020, 2022 and 2024 Development of Low Power Electronics: An Opportunity for Wearable Electronics Market Ultra-low Power Microcontrollers Extend Battery Life of High- Performing, New Generation Wearable Devices: Global Ultra-low Power Microcontroller Market (In US$ Billion) for the Years 2018, 2020, 2022 & 2025 A Peek into Enabling Technologies Technical Aspects of Wearable Devices Sensor Integration for Advanced Wearable Technology Battery Power: An Important Criterion for Success Technology Advancements Power Wearable Electronics Market Collaboration Vital for Innovations in Wearable Tech Key Challenges Confronting Wearable Electronics Market Common Issues with Wearable Electronics Wearables Attract Venture Capital Funding

4. GLOBAL MARKET PERSPECTIVE Table 1: World Current & Future Analysis for Wearable Electronics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 2: World 7-Year Perspective for Wearable Electronics by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets for Years 2020 & 2027

Table 3: World Current & Future Analysis for Wristwear by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 4: World 7-Year Perspective for Wristwear by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 5: World Current & Future Analysis for Eyewear by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 6: World 7-Year Perspective for Eyewear by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 7: World Current & Future Analysis for Hearables by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 8: World 7-Year Perspective for Hearables by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 9: World Current & Future Analysis for Bodywear by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 10: World 7-Year Perspective for Bodywear by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 11: World Current & Future Analysis for Other Products by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 12: World 7-Year Perspective for Other Products by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 13: World Current & Future Analysis for Memory by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 14: World 7-Year Perspective for Memory by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 15: World Current & Future Analysis for Sensor by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 16: World 7-Year Perspective for Sensor by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 17: World Current & Future Analysis for Display by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 18: World 7-Year Perspective for Display by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 19: World Current & Future Analysis for Connectivity by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 20: World 7-Year Perspective for Connectivity by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 21: World Current & Future Analysis for PCBs by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 22: World 7-Year Perspective for PCBs by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 23: World Current & Future Analysis for Other Components by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 24: World 7-Year Perspective for Other Components by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 25: World Current & Future Analysis for Consumer Electronics by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 26: World 7-Year Perspective for Consumer Electronics by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 27: World Current & Future Analysis for Healthcare by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 28: World 7-Year Perspective for Healthcare by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 29: World Current & Future Analysis for Enterprise & Industrial by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 30: World 7-Year Perspective for Enterprise & Industrial by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

Table 31: World Current & Future Analysis for Other Applications by Geographic Region - USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 32: World 7-Year Perspective for Other Applications by Geographic Region - Percentage Breakdown of Value Sales for USA, Canada, Japan, China, Europe, Asia-Pacific and Rest of World for Years 2020 & 2027

III. MARKET ANALYSIS

GEOGRAPHIC MARKET ANALYSIS

UNITED STATES Wearable Electronics Market in the US: An Overview Penetration of Wearables among Adults in the US: Adult Wearable Users as % of Population Americans Rise Up to ?Quantified Self? Evolving Healthcare in the US to Drive Demand for Wireless Devices Wearable Devices to Mitigate Medical Concerns of Elderly Individuals US Population Breakdown by Age Group (in %) for 2019 Table 33: USA Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 34: USA 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 35: USA Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 36: USA 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 37: USA Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 38: USA 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

CANADA Table 39: Canada Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 40: Canada 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 41: Canada Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 42: Canada 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 43: Canada Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 44: Canada 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

JAPAN Table 45: Japan Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 46: Japan 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 47: Japan Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 48: Japan 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 49: Japan Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 50: Japan 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

CHINA Wearable Technology Adoption on the Rise in China Chinese Wearable Electronics Market Share Analysis (in %): 2019 Table 51: China Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 52: China 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 53: China Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 54: China 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 55: China Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 56: China 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

EUROPE Market Facts & Figures European Wearable Electronics Market: Competitor Market Share Scenario (in %) for 2019 Market Analytics Table 57: Europe Current & Future Analysis for Wearable Electronics by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets - Independent Analysis of Annual Sales in US$ Million for Years 2020 through 2027

Table 58: Europe 7-Year Perspective for Wearable Electronics by Geographic Region - Percentage Breakdown of Value Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2020 & 2027

Table 59: Europe Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 60: Europe 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 61: Europe Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 62: Europe 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 63: Europe Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 64: Europe 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

FRANCE Table 65: France Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 66: France 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 67: France Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 68: France 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 69: France Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 70: France 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

GERMANY Table 71: Germany Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 72: Germany 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 73: Germany Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 74: Germany 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 75: Germany Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 76: Germany 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

ITALY Table 77: Italy Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 78: Italy 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 79: Italy Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 80: Italy 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 81: Italy Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 82: Italy 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

UNITED KINGDOM Table 83: UK Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 84: UK 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

Table 85: UK Current & Future Analysis for Wearable Electronics by Component - Memory, Sensor, Display, Connectivity, PCBs and Other Components - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 86: UK 7-Year Perspective for Wearable Electronics by Component - Percentage Breakdown of Value Sales for Memory, Sensor, Display, Connectivity, PCBs and Other Components for the Years 2020 & 2027

Table 87: UK Current & Future Analysis for Wearable Electronics by Application - Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 88: UK 7-Year Perspective for Wearable Electronics by Application - Percentage Breakdown of Value Sales for Consumer Electronics, Healthcare, Enterprise & Industrial and Other Applications for the Years 2020 & 2027

REST OF EUROPE Table 89: Rest of Europe Current & Future Analysis for Wearable Electronics by Product - Wristwear, Eyewear, Hearables, Bodywear and Other Products - Independent Analysis of Annual Sales in US$ Million for the Years 2020 through 2027

Table 90: Rest of Europe 7-Year Perspective for Wearable Electronics by Product - Percentage Breakdown of Value Sales for Wristwear, Eyewear, Hearables, Bodywear and Other Products for the Years 2020 & 2027

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The global market for Wearable Electronics is projected to reach US$61.4 billion by 2025 - GlobeNewswire

Yes, even your metabolism has a memory and it can hold a grudge for years. In people with diabetes, periods of high blood sugar can negatively impact their health years later, even if they get their blood sugar under control. While this metabolic memory phenomenon has been known for years, why it happens is poorly understood.

Rama Natarajan, Ph.D., Professor and Chair of the Department of Diabetes Complications & Metabolism at City of Hope, turned to our epigenome for the answer.

Weve shown the first link between DNA methylation in blood and stems cells, blood sugar history, and future development of complications, said Natarajan. This highlights the importance of good glycemic control to prevent long-term complications.

The history of metabolic memory

We now know high blood sugar can lead to a variety of complications, including eye disease, kidney disease, nerve problems, heart disease, and stroke. But the relationship between strict blood sugar control and complication risk wasnt well understood before the 1980s.

Back in 1983, the Diabetes Control and Complications Trial (DCCT) began tracking complications in 1,441 participants with type 1 diabetes. Researchers compared the occurrence of long-term complications between participants who tightly regulated their blood glucose levels to those who followed less strict standard regulation.

After 10 years, the difference was striking the risk of diabetic complications was reduced in participants who tightly regulated their blood sugar but not in those following standard regulation. In other words, a person with higher blood sugar had a higher risk of complications.

To continue following the DCCT patients, the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up trial began at the end of DCCT in 1993 and is ongoing. At the end of DCCT, all participants were encouraged to adopt strict blood sugar regulation; many in the standard regulation group did.

Despite blood sugar regulation being very similar in all the patients (as measured by hemoglobin A1c, called HbA1c), differences persisted between the two original intervention groups. The phenomenon of long-term effects from high or variable blood sugar control is called metabolic memory (or the legacy effect in type 2 diabetes).

Complications resulted from total high blood sugar exposure it didnt matter whether the person was exposed to slightly elevated levels over a long time or high levels over a short time.

So, what caused the sweet sugar molecule to become so destructive?

Sugary destruction

Extra sugar in your blood can interact with your cells, DNA, and proteins, adding itself onto things it shouldnt be on through a process called glycation. In fact, HbA1c can be thought of as sugar-coated red blood cells.

The sugar-coated molecules cant function as well, if at all, and the damage begins a self-perpetuating cycle. Not only do these damaged molecules stop working, they can also accumulate in the skin, eyes, and other organs, causing damage. Build-up of sugar-coated molecules can trigger the creation of harmful free radicals, causing oxidative stress and feeding a destructive cycle.

Although sugar can directly modify molecules, it can also trigger other epigenetic modifications. These modifications can control how genes are expressed, changing protein levels in cells.

There hasnt been a strong genetic association with diabetic complications very few genetic mutations have been strongly linked to complications, Natarajan explained. But we knew the epigenome is what makes identical twins different and can have implications into why one gets diabetes or cancer and the other doesnt. So, we turned our focus to epigenetics.

Epigenetics and diabetes

Natarajan sought to explain the long-term sugary destruction wrought by high blood sugar by searching the epigenome. Her lab specifically looks for one type of modification called DNA methylation, where a tiny molecule called a methyl group is added onto DNA.

Epigenetics is the coating on top of genetics that can be altered by environmental influences, Natarajan said. We started focusing on the role of epigenetics in developing diabetes and its complications because we know that lifestyles, improper diet, lack of exercise, and even viruses can affect epigenetics.

Natarajans lab began collaborating with the DCCT trial group, analyzing data collected through the trial for epigenetic clues to explain the metabolic memory of complications. They found more modifications associated with active genes on proteins called histones that are wrapped by DNA in participants with regular blood sugar control compared to the strict controllers. Even more interesting was that many epigenetic DNA methylation variations between the two groups persisted through at least 17 years of follow-up in the EDIC study.

These changes were in important genes related to complications, showing something about persistent epigenetic programming in peripheral blood cells, commented Natarajan. Previous high blood sugar episodes could be a key factor in why these genes were continually misbehaving.

Now, Natarajans lab illuminated even more links between epigenetic changes, blood sugar history, and metabolic memory in their recent Nature Metabolism paper. Persistent epigenetic modifications of a few key genes were detected in participants with previously less regulated blood sugar who developed either retinopathy or nephropathy. They showed that DNA methylation is a key link between a patients HbA1c history, metabolic memory, and development of future complications.

Many HbA1c-associated modifications were in stem cells and the blood cells they create. Even though blood cells are turned over relatively quickly, stem cells stick around for a long-time, so changes in stem cells can have long-term consequences.

The important thing we found was the connection to stem cells, explained Natarajan. Were asking how these changes alter inflammatory gene expression and how we can interrupt those pathways.

Sugar-modified genes arent so sweet

Natarajans lab sorted through all the modified genes to find the most common modifications in participants with less strict blood sugar control. The most commonly modified gene coded for thioredoxin-interacting protein (TxNIP).

TxNIP is not a new protein, but the discovery that its DNA methylation is altered by different glycemic control is new, Natarajan added.

Thioredoxin-interacting protein is known to be highly regulated in certain pancreas cells, called beta cells, that release insulin. The plot thickened when high blood sugar was found to increase TxNIP protein production. Even more interesting, high TxNIP protein levels make beta-cells dysfunctional, ultimately leading to their untimely death. So, high blood sugar triggers more TxNIP to be produced, possibly through epigenetic modifications of the TxNIP gene, which ultimately leads to the death of insulin-producing beta cells.

Showing that the TxNIP gene can be epigenetically modified for years and years suggests that it could be one of the culprits causing long-term problems in diabetes, Natarajan said.

The proteins that TxNIP interacts with, called thioredoxins, protect against oxidative stress. TxNIP can bind to and inactivate thioredoxin to increase oxidative stress by increasing reactive oxygen species (ROS). In mouse cells in a dish, high glucose exposure triggered increased ROS levels mediated by TxNIP, leading to oxidative stress. Oxidative stress can trigger cell and organ damage, so this could be one mechanism explaining diabetes-induced damage.

Her lab also found epigenetic changes in other genes related to inflammation and inflammation-related processes.

Next steps and clinical implications

Natarajans lab is continuing to study the link between blood sugar history, epigenetics, and other complications of diabetes. They are also expanding their scope, searching the entire genome for more epigenetic modifications linked with past blood sugar maintenance.

This study also lays the groundwork for further studies with meaningful clinical implications, including developing epigenetic biomarkers for diabetic complications. In the future, Natarajan says a simple blood test looking at key epigenetic modifications, along with HbA1c history, could be used to predict future risk of retinopathy, nephropathy, and neuropathy. This would allow the doctor to figure out who should have early and more aggressive treatment to mitigate complication risk.

While these studies were done in type 1 diabetes patients, other studies in type 2 diabetes patients have shown similar epigenetic modifications after history of higher blood sugar levels.

Turning knowledge into potential drugs

What about doing something about the epigenetic modifications can we remove them? As a matter of fact, yes!

There is an interesting new type of experimental drug on the horizon called epigenetic editing. The hot new technology CRISPR isnt just for cutting out chunks of DNA or controlling genes it can also be used to insert or remove epigenetic modifications. While this technology is still experimental and in early preclinical animal studies, the potential is very exciting.

A CRISPR/enzyme pair can be used the CRISPR genetic material can hunt down the genetic spot you want to change; and the attached enzyme can snip or add certain molecules to the DNA, effectively removing or creating an epigenetic modification, thereby activating or silencing the targeted gene.

Enzymes such as methyltransferase or demethylase can add or remove methyl groups from genes. Because they just change what is on the gene or histone wrapped around it (not the genetic sequence itself), the gene itself isnt tampered with, meaning there could be less genetic complications associated with CRISPR epigenetic editing.

This is a futuristic thing, Natarajan concluded. The combination of genetics and epigenetics is going to be the future of personalized medicine.

Original post:
Can High Blood Sugar Haunt People with Diabetes Even After it is Under Control? - BioSpace