StemCell Therapy

BASKING RIDGE, N.J., Oct. 21, 2020 (GLOBE NEWSWIRE) -- Caladrius Biosciences, Inc. (Nasdaq: CLBS) (Caladrius or the Company), a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse, not manage, disease, announced today that its Chief Medical Officer, Douglas W. Losordo, M.D., FACC, FAHA, will participate in 8th annual Chief Medical Officer Summit 360, being held virtually on October 26-27, 2020.

Breakout Session Details: Title: Tracking Personalized Medications in Gene and Cell TherapyDate/Time: October 26, 2020 at 3:00 p.m.

For more information on the 8th annual CMO Summit 360, or to register, please click here.

About Caladrius Biosciences

Caladrius Biosciences, Inc. is a clinical-stage biopharmaceutical company dedicated to the development of cellular therapies designed to reverse, not manage, disease. We are developing first- in-class cell therapy products based on the notion that our body contains finely tuned mechanisms for self-repair. Our technology leverages and enables these mechanisms in the form of specific cells, using formulations and modes of delivery unique to each medical indication.

The Companys current product candidates include CLBS119, a CD34+ cell therapy product candidate for the repair of lung damage in patients with COVID-19 who are experiencing respiratory failure, for which the Company recently initiated a clinical trial as well as three developmental treatments for ischemic diseases based on its CD34+ cell therapy platform: HONEDRA (formerly CLBS12), recipient of SAKIGAKE designation and eligible for early conditional approval in Japan for the treatment of critical limb ischemia (CLI) based on the results of an ongoing clinical trial; CLBS16, the subject of a recently completed positive Phase 2a clinical trial in the U.S. and slated to begin a comprehensive Phase 2b trial in the U.S. during 4Q20 for the treatment of coronary microvascular dysfunction (CMD); and CLBS14, a Regenerative Medicine Advanced Therapy (RMAT) designated therapy for which the Company has finalized with the U.S. Food and Drug Administration (the FDA) a protocol for a Phase 3 confirmatory trial in subjects with no-option refractory disabling angina (NORDA). For more information on the company, please visit http://www.caladrius.com.

Contact:

Investors:Caladrius Biosciences, Inc.John MendittoVice President, Investor Relations and Corporate CommunicationsPhone:+1-908-842-0084Email:jmenditto@caladrius.com

Media:W2O GroupChristiana PascalePhone: +1-212-257-6722Email:cpascale@w2ogroup.com

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Caladrius Biosciences to Participate in the 8th Annual Chief Medical Officer Summit 360 - GlobeNewswire

GeekWire Summit panelists, clockwise from top left: Threshold co-founder Emily Melton; Canaan Partners general partner Nina Kjellson; and Biomatics Capital co-founder Julie Sunderland.

Investor interest in healthcare technology is on the rise amid a pandemic that has put a spotlight on telemedicine, patient monitoring, and more. Global VC funding to digital health companies reached a record $10.3 billion through the first nine months of this year, up 43% year-over-year, according to Mercom Capital Group.

At the GeekWire Summit on Tuesday, we brought together three investors who are spending time at the crossroads of technology and healthcare. Read on for takeaways from the conversation, which included Threshold co-founder Emily Melton, Biomatics Capital co-founder Julie Sunderland, and Canaan Partners general partner Nina Kjellson. Dr. Robert Overell, president of Foundation BioVenture, moderated the discussion.

No slowdown: Nearly all industries braced for the worst when COVID-19 began spreading. But the investors agreed that activity within the healthcare tech market is now accelerating. Sunderland called out the progress being made with COVID-19 therapeutics and vaccines, as well as advances with telemedicine and remote care.

Its been a good signal of the thesis we all have, which is that we live at an extraordinary time in terms of innovation in biopharma and innovation in the application of technology to healthcare, Sunderland said.

Melton added: We are not seeing a slowdown now. If anything, its actually faster than its ever been and one of the most competitive markets Ive ever been involved in.

Holy grail:As remote care becomes more common, collecting reliable data from patients outside the clinic or hospital and making it seamless will be paramount. Kjellson called it the holy grail of remote care.

Whether its for clinical use to practice better medicine, or for clinical trials to get better data, that is a trend accelerated by COVID and is here to stay and will drive value going forward, she said. From an investment basis, if we can improve that reliably, we should be looking for those opportunities and investing in those opportunities. It will make better medicines, it will drive better clinical trials, its good for the healthcare system.

Melton said thats particularly true if the right value-based incentive business models are also put in place so people are encouraged to participate in the data collection process.

Sunderland said shes excited about using data to drive behavior change, but the lack of payment mechanisms is a roadblock to capturing value and building new businesses.

When you run into that wall of trying to sell tools into the payer system, and you realize how hard it is and how long those enterprise cycles are and how hard it is to get to scale even if you were creating value from patients, you get discouraged pretty quickly, she said.

Not just computers for healthcare: The relationship between tech and healthcare is rapidly evolving as digital tools and services are applied across various sectors.

Melton called out Livongo, the digital disease management company that announced its $18.5 billion acquisition by Teladoc Health in August. The Livongo solution includes both hardware such as monitoring devices, and software that provides data insights and enables patient communication.

We get excited about those intersections, said Melton, whose firm invested in Livongo. Its not just thinking about only investing in software companies or services businesses or medical devices companies, but looking at where to bring those pieces together to create unique experiences that drive more value.

Kjellson added that many biotech companies are now built on the power of informatics, whether its processing data or doing faster DNA sequencing. She also brought up Vineti, which sells software that helps manage the supply chain and manufacturing process for biotech firms developing personalized treatments. The company counts both Threshold and Canaan Partners as investors.

Vineti is trying to be the enterprise solution to modernize how you connect all of these nodes from the couriers to clinicians to the manufacturers so you have a really safe, seamless, transparent process for how precision medicine gets delivered to patients, Kjellson said. Thats a very different way of thinking about health IT than computers for healthcare.'

[The full interview with the healthtech investors, and other GeekWire Summit sessions, are available on-demand exclusively to attendees of the virtual event.Learn more and register here.]

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Healthtech investors on the holy grail of remote care and a new way of thinking about health IT - GeekWire

CGA members will be able to access on-site rapid testing for Covid-19 subject to Health Canada approvals

VANCOUVER, British Columbia, Oct. 22, 2020 (GLOBE NEWSWIRE) -- Victory Square Health Inc. (VS Health or the "Company") a portfolio company of Victory Square Technologies Inc. ("Victory Square'') (CSE:VST) (OTC:VSQTF) (FWB:6F6) has entered into an agreement with the Canadian Gaming Association (CGA), a national trade association representing the leading operators and suppliers in Canadas casino gaming and lottery industry subject to Health Canada approval.

The Company announced on October 6, 2020 that it had submitted all formal documents and research for Health Canada approval of its proprietary Safetest Covid-19 Rapid test. This sales, distribution and testing agreement will enable VS Health to assist the members of one of Canadas largest hospitality industry associations ensuring the health and safety of the 180,000 employees that make up the gaming industry in Canada. Before the industry shut down in March, Canadian casino and bingo operators had over 50 million unique visits annually to their properties.

This Safetest Covid-19 Rapid Testcomplement will allow each participating property to access rapid, easy, efficient and cost-effective daily Covid-19 Rapid tests to ensure employees are not infected with the Covid-19 virus, which will in turn keep workplaces safe. The test may also be administered to customers, subject to Health Canada approvals.

We are very pleased to engage with Victory Square Health, said Paul Burns, President and CEO of the Canadian Gaming Association. We believe that providing access to rapid testing, like the Safetest Rapid Test product, is one of the most important tools to help reopen our economy and to allow for greater confidence in increasing capacities in venues across the hospitality industry.

I am delighted with this important agreement with the CGA so that Victory Square Health may realize its goal of commencing distribution of its exclusive Rapid Test kits on a national scale, said Victory Square CEO Shafin D. Tejani. The gaming and entertainment industries have been adversely affected by this pandemic and we are confident that our products and testing services will enable these properties to reopen and increase capacity through our Covid-19 tests. We look forward to providing our Safetest Rapid Test kits and testing services to all companies affected by Covid-19 following Health Canada approvals so that they can get their teams back to work and help grow our economy.

Victory Square Health is committed to assisting Canadians and Canadian organizations. The company recently announced a strategic partnership with the Canadian Police Association and its members across Canada.

VS Health was founded in 2016 to accelerate the development of personalized medicine and technology solutions including diagnostic tests to support patient care and improve health outcomes. Its first product, the Leishmaniasis Rapid Test, was developed in partnership with the UFMG, Federal University of Minas Gerais. Safetest took advantage of its expertise in the subject to develop other antibody-based tests and a robust R&D pipelines of diagnostic kits for Hansens Disease, Brucellosis, HTLV and blood sample screening tests.

Disclaimer:

The Company is not making any express or implied claims that its product has the ability to eliminate, cure or contain the Covid-19 (or SARS-2 Coronavirus) at this time.

*These figures have been vetted by the Canadian Gaming Association

Go to: VictorySquare.com and sign up for VSTs official newsletter at http://www.VictorySquare.com/newsletter

On behalf of the board,

Shafin Diamond TejaniChief Executive OfficerVictory Square Technologies

For further information about the Company, please contact:

Investor Relations Contact Alex TziliosEmail: alexandros@victorysquare.comTelephone: 778-867-0482

Media Relations Contact Howard Blank, DirectorEmail: howard@victorysquare.comTelephone: 604-928-6066

ABOUT VICTORY SQUARE TECHNOLOGIES INC.

Victory Square (VST) builds, acquires and invests in promising startups, then provides the senior leadership and resources needed to fast-track growth.

VST's sweet spot is the cutting-edge tech that's shaping the 4th Industrial Revolution. Our portfolio consists of 23 global companies using AI, VR/AR and blockchain to disrupt sectors as diverse as fintech, insurance, health and gaming.

What we do differently for startups

VST isn't just another investor. With real skin in the game, we're committed to ensuring each company in our portfolio succeeds. Our secret sauce starts with selecting startups that have real solutions, not just ideas. We pair you with senior talent in product, engineering, customer acquisition and more. Then we let you do what you do best build, innovate and disrupt. In 24-36 months, you'll scale and be ready to monetize.

What we do differently for investors

VST is a publicly traded company headquartered in Vancouver, Canada, and listed on the Canadian Securities Exchange (VST), Frankfurt Exchange (6F6) and the OTCQX (VSQTF).

For investors, we offer early-stage access to the next unicorns before they're unicorns.

Our portfolio represents a uniquely liquid and secure way for investors to get access to the latest cutting-edge technologies while also tapping into emerging global trends with big upsides. For more information, please visit http://www.victorysquare.com.

ABOUT CGA:

The Canadian Gaming Association (CGA) is a national trade association that works to advance the evolution of Canadas gaming industry. The associations mandate is to promote the economic value of gaming in Canada; use research, innovation, and best practices to help the industry advance; and create productive dialogue among stakeholders.

Forward Looking Statement

This news release contains forward-looking information within the meaning of applicable securities laws relating to the outlook of the business of Victory Square, including, without limitation, statements relating to future performance, execution of business strategy, future growth, business prospects and opportunities of Victory Square and its related subsidiaries, including Victory Square Health Inc., and other factors beyond our control. Such forward-looking statements may, without limitation, be preceded by, followed by, or include words such as believes, expects, anticipates, estimates, intends, plans, continues, project, potential, possible, contemplate, seek, goal, or similar expressions, or may employ such future or conditional verbs as may, might, will, could, should or would, or may otherwise be indicated as forward-looking statements by grammatical construction, phrasing or context. All statements other than statements of historical facts contained in this news release are forward-looking statements. Forward-looking information is based on certain key expectations and assumptions made by the management of Victory Square. Although Victory Square believes that the expectations and assumptions on which such forward looking information is based are reasonable, undue reliance should not be placed on them because Victory Square can give no assurance that they will prove to be correct. Actual results and developments may differ materially from those contemplated by these statements. The statements contained in this news release are made as of the date of this news release. Victory Square disclaims any intent or obligation to update publicly any forward-looking information, whether as a result of new information, future events or results or otherwise, other than as required by applicable securities laws.

The Canadian Securities Exchange has neither approved nor disapproved the contents of this news release and accepts no responsibility for the adequacy or accuracy hereof.

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Victory Square Technologies Portfolio Company enters into Sales & Distribution agreement with the Canadian Gaming Association - GlobeNewswire

Healthcare technology and data are taking on more diverse roles than ever before

Technology changes healthcare treatments and solutions every day. With rapidly developing life-saving tech and informatics systems, healthcare providers are better able to accumulate and apply data for beneficial results.

Modern tech makes this evolving system of informatics possible. A single medical study can gather 100 terabytes of data thats as much as 21,300 DVDs worth of information. This data can then be analyzed and applied using smart tech to improve the state of healthcare for everyone.

In the course of the healthcare evolution, technology and data are taking on more diverse roles than ever before. Now, nursing informatics is being developed to protect patient health, safety, and privacy. 3D-printing techniques are making it possible to reproduce organs. And telematics is allowing for more comfortable, accessible care, especially during the pandemic.

Here, we explore how the evolving roles of technology and informatics are shaping the healthcare industry.

Nursing informatics, safety, and privacy

Nursing is one of the most vital careers to maintain a healthy society. As the frontline of healthcare treatment, nurses manage the difficult task of juggling patient care with data systems. In the course of this work, they discover, treat, and record patient health.

By integrating evolving informatics technology into the traditional role of nursing, these caretakers of public health are better able to find effective solutions while protecting sensitive patient data. Healthcare data is a primary target of cybercriminals due to its valuable nature. Because of this, nurses shoulder the evolving burden of managing data protections alongside care provisions.

In the scope of this protection, the specialist role of nursing informatics has emerged to help bridge the gap between the technical aspects of nursing and the clinical side. A nursing informatics specialist combines technology with the care and communicative aspects of nursing to customize software and hardware for care solutions.

Through pairing data and smart tech with the human aspect of care, care solutions are evolving. Informatics in nursing makes this possible.

Take, for instance, the pathology and personalized medicine solutions being created by healthcare company Paige. The smart tools this company is producing can assist in nursing and pathology to present genomic information at a glance for better immediate communication and treatment. Through computer analysis of tissue, Paiges tech can give care providers diagnostic information almost instantly without destroying a genomic sample.

Solutions like these are made possible by big data. A database is analyzed, then an AI system guides nurses or pathologists to a correct condition or treatment plan with better accuracy.

This assists in communication with other healthcare providers while allowing nurses to provide more specialized immediate care. On the whole, the evolution of nursing informatics tech is making care more efficient.

3D-printing and the future of healthcare

Like something out of science fiction, 3D-printing is arriving on the healthcare scene to create previously unfathomable care solutions. The role of 3D-printing tech is evolving into a life-saving component of regenerative and personalized medicine. With the ability to print organs for transplant using simple tissue and blood draws, this technology is the future of healthcare.

Dr. Anthony Atala and his team were able to grow human organs and tissues using additive manufacturing processes and collagen substrates. Combining human cells with 3D-printing allowed them to form replacement organs like heart valves, trachea, livers, and even genitalia.

The lifesaving implications of this tech are astounding. With a relatively simple design and usability process, medical professionals can more safely conduct transplants. Building personalized organs removes the painful threat of bodily rejection. Additionally, waitlists for transplants could become a thing of the past. New organs grown directly with a persons bodily tissue mean miraculous recovery for millions of patients.

Telematics and accessibility

In a world facing a pandemic, finding innovative healthcare solutions like these is more important than ever. Evolving technology makes healthcare accessibility possible. Regardless of geographic location, vulnerable patients can receive treatment in the form of telemedicine and telematics.

Telematics gathered and applied through virtual conferencing have proven especially vital due to COVID-19, where each healthcare visit presents a risk in itself. As a result, the field of telemedicine is growing all the time.

Care providers using smart tools can meet virtually with patients, analyze issues, diagnose problems, and assign treatment. In the pandemic environment, this means no risky face-to-face meetings where they can be avoided. This keeps some of the most vulnerable individuals safe.

Telemedicine is a viable solution for a wide number of healthcare visits. Vein restoration through telemedicine is even possible, with physicians able to virtually assess varicose veins through a video call, connecting with patients in real-time to provide treatment.

Providers like TeraPractice make virtual care a focus of their practice. This allows them to provide convenient access to patients while managing costs for everyone. With such a beneficial combination of results, telematics and telemedicine is evolving as a key element of healthcares future.

Final thoughts

Issues abound in the healthcare system that have yet to see bipartisan agreement. This makes progress on the regulatory side of healthcare slow. However, new technology that addresses issues like accessibility means improvements in care for millions.

The role of technology while always vital has evolved to prove that the future of healthcare is already here. Through smart tools, nurses can better integrate data and communicative solutions. Meanwhile, 3D-printing has real life-saving potential. In the wake of a global pandemic, these tools alongside telematics make healthcare safer, more accessible, and more affordable for everyone.

(Image Source: Pexels)

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The evolving role of technology and informatics in healthcare - VatorNews

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Personalized medicine diagnosing, monitoring, and giving the treatment to the individual according to the segmentation of disease risks and characteristics of each patient. This approach relies on the scientific research results and how the persons molecular nature along with genetic profile makes them susceptible to the particular disease. The research on personalized medicine id increasing the ability to predict the medical treatment which can be safe and effective to people and which can not.

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In the extensive primary research process undertaken for this study, the primary sources Postal Surveys, telephone, Online & Face-to-Face Survey were considered to obtain and verify both qualitative and quantitative aspects of this research study. When it comes to secondary sources Companys Annual reports, press Releases, Websites, Investor Presentation, Conference Call transcripts, Webinar, Journals, Regulators, National Customs and Industry Associations were given primary weight-age.Get More Information: https://www.advancemarketanalytics.com/reports/29170-global-personalized-medicine-marketWhat benefits does AMA research studies provides?

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Personalized Medicine Market to Eyewitness Massive Growth by 2025 - re:Jerusalem

Researchers at the Massachusetts Institute of Technologys (MIT) research enterprise Critical Analytics for Manufacturing Personalized Medicine (CAMP) have been awarded Intra-CREATE grants from the National Research Foundation (NRF).The grants will support research on retinal biometrics for glaucoma progression and neural cell implantation therapy for spinal cord injuries.

Krystyn Van Vliet, co-lead Principal Investigator at Singapore-MIT Alliance for Research and Technology (SMART) CAMP, and Professor of Materials Science and Engineering at MIT, said: Singapores well-established biopharmaceutical ecosystem brings with it a thriving research ecosystem that is supported by skilled talents and strong manufacturing capabilities. We are excited to collaborate with our partners in Singapore, bringing together an interdisciplinary group of experts from MIT and Singapore, for new research areas at SMART.

In addition to our existing research on our three flagship projects, we hope to develop breakthroughs in manufacturing other cell therapy platforms that will enable better medical treatments and outcomes for society.

Hosted by SMART CAMP, the first research project, Retinal Analytics via Machine learning aiding Physics (RAMP), brings together an interdisciplinary group of ophthalmologists, data scientists, and optical scientists from SMART, Singapore Eye Research Institute (SERI), Agency for Science, Technology and Research (A*STAR), Duke-NUS Medical School, Massachusetts Institute of Technology (MIT), and National University of Singapore (NUS). The team will seek to establish first principles-founded, and statistically confident models of, glaucoma progression in patients, which will enable rapid and reliable forecast of the rate and trajectory of glaucoma progression, leading to better targeted treatments.

MIT Mechanical Engineering Professor Barbastathis, co-leader of the research and Principal Investigator at SMART CAMP said: We look forward to leveraging the ideas fostered in SMART CAMP to build data analytics and optical imaging capabilities for this pressing medical challenge of glaucoma prediction.

The second research project, Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (ScaNCellS), gathers an interdisciplinary group of engineers, cell biologists, and clinician scientists from SMART, Nanyang Technological University (NTU), NUS, IMCB A*STAR, A*STAR, French National Centre for Scientific Research (CNRS), University of Cambridge, and MIT.

The team will seek to design a combined scaffold and neural cell implantation therapy for spinal cord injury treatment that is safe, efficacious, and reproducible, paving the way forward for similar neural cell therapies for other neurological disorders. The project aims to achieve its goals through an enhanced biological understanding of the regeneration process of nerve tissue and optimised engineering methods to prepare cells and biomaterials for treatment.

Chew Sing Yian, Principal Investigator at SMART CAMP and Associate Professor of the School of Chemical and Biomedical Engineering, and Lee Kong Chian School of Medicine, at NTU said: Our earlier SMART and NTU scientific collaborations on progenitor cells in the central nervous system are now being extended to cell therapy translation. This helps us address SCI in a new way, and connect to the methods of quality analysis for cells developed in SMART CAMP.

Cell therapy, one of the fastest-growing areas of research, will provide patients with access to more options that will prevent and treat illnesses, some of which are currently incurable. Glaucoma and spinal cord injuries affect many, said Hanry Yu, co-lead Principal Investigator at SMART CAMP.

Our research will seek to plug current gaps and deliver valuable impact to cell therapy research and medical treatments for both conditions. With a good foundation to work on, we will be able to pave the way for future exciting research for further breakthroughs that will benefit the healthcare industry and society.

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New support for personalised medicine and cell therapy - Health Europa

Addressing gaps in testing and education within precision oncology can assist in improving access to patients of color and other underserved populations.

Addressing gaps in testing and education within precision oncology can assist in improving access to patients of color and other underserved populations, said Karen Winkfield, MD, PhD, incoming executive director, Meharry-Vanderbilt Alliance.

Transcript

AJMC: In the era of precision medicine, what can oncologists do to ensure that newer therapies are the right choice for minority patients?

Dr Winkfield: Precision oncology has really come a long way, and I do think that oftentimes people think about it as just genetic testing or genomic testing. That's important, and we do know that there's a gap, even in terms of testing, for some things as simple as an oncotype for breast cancer patients. We know that Black patients are not getting the oncotype test at the same rate as other racial and ethnic groups.

So, really, just making sure that there's access is one thing that can be important. Whether it be partnering with some of the testing facilities to make sure that there is opportunity for individuals who may be underinsured or uninsured to gain access to some of these precision oncology tests, that would be wonderful.

The other thing is making sure people understand, again, community engagement. I'm going to keep coming back to that, because patients need to understand the importance of it and know that they're not being a guinea pig, etc, but that we want to make sure that their treatment is personalized. The personalization is not just to them as an individual, but also to their tumor and what their tumor might be doing. So, that communication is important as well.

So, sometimes it may require a second biopsy. So, you can imagine, if a person has gone through therapy and then their tumor is not responding, and you say, "Oh, we need to get some more tissue," there can be some misunderstandings about that. So, really being open with your patients about the rationale and the reason for getting additional tissue, but, again, making sure that patients don't have very high out-of-pocket cost is one of the things that I think will go a long way to improving access to patients of color and other underserved populations to precision oncology.

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Dr Karen Winkfield on Improving Minority Access, Education for Precision Oncology - AJMC.com Managed Markets Network

OncoHost, announced on 5th October that Professor Yuval Shaked, co-founder and Chief Scientific Advisor at OncoHost, and Professor of Cell Biology and Cancer Science at the Technion Israel Institute of Technology, will deliver a presentation titled A Proteomics-Based Platform for Predicting Response to Immunotherapy and Personalizing Treatment Plans at the MAP 2020 Virtual Congress - ESMO this Friday, October 9th at 17:20 PM CEST.

The presentation will show how through the analysis of host response profiles (i.e. the patients reaction), oncologists may be able to harness this information to better predict clinical outcomes and suggest the ideal combination treatment with immunotherapy.

Despite major clinical success, immunotherapy treatments have demonstrated efficacy in only a small proportion of patients with non-small cell lung cancer (NSCLC), said Prof. Yuval Shaked. OncoHosts studies have indicated that individual host response to anti-cancer treatment can generate pro-tumorigenic activities and support tumor re-growth and spread. It is therefore vital to analyze and earlier predict host response to treatment in order to improve outcomes and reduce unnecessary side effects experienced by so many patients.

Using machine learning (ML)-based analysis and algorithms to identify highly predictive cohort-based proteomic signatures in patients, personalized response prediction can be used to improve precision medicine in oncology. Personalized treatment plans can then be created through information based on cohort-based statistical analysis, personalized adaption and finally, translation to clinically relevant targets.

Prof. Shakeds presentation will include a real-life case study on whom a Host Response profile analysis was performed, and will be followed by a live Q&A.

MAP is the leading congress in precision medicine in oncology in Europe, established by key opinion leaders in the field. The name of the Congress was recently changed into Molecular Analysis for Precision Oncology to better reflect its aims of focusing on science, translational research, education and collaboration. This years event will be held virtually on October 9-10.

Excerpt from:
OncoHost Data on Host Immunotherapy Response to be Presented This Week - Technology Networks

BINYAMINA, Israel, Oct. 5, 2020 /PRNewswire/ -- OncoHost, a global leader in host response profiling for improved personalized cancer therapy, announced today that Professor Yuval Shaked, co-founder and Chief Scientific Advisor at OncoHost, and Professor of Cell Biology and Cancer Science at the Technion Israel Institute of Technology, will deliver a presentation titled A Proteomics-Based Platform for Predicting Response to Immunotherapy and Personalizing Treatment Plans at the MAP 2020 Virtual Congress - ESMOthis Friday, October 9th at 17:20 PM CEST.

The presentation will show how through the analysis of host response profiles (i.e. the patient's reaction), oncologists may be able to harness this information to better predict clinical outcomes and suggest the ideal combination treatment with immunotherapy.

"Despite major clinical success, immunotherapy treatments have demonstrated efficacy in only a small proportion of patients with non-small cell lung cancer (NSCLC)," said Prof. Yuval Shaked. "OncoHost's studies have indicated that individual host response to anti-cancer treatment can generate pro-tumorigenic activities and support tumor re-growth and spread. It is therefore vital to analyze and earlier predict host response to treatment in order to improve outcomes and reduce unnecessary side effects experienced by so many patients."

Using machine learning (ML)-based analysis and algorithms to identify highly predictive cohort-based proteomic signatures in patients, personalized response prediction can be used to improve precision medicine in oncology. Personalized treatment plans can then be created through information based on cohort-based statistical analysis, personalized adaption and finally, translation to clinically relevant targets.

Prof. Shaked's presentation willinclude a real-life case study on whom a Host Response profile analysis was performed, and will be followed by a live Q&A.

MAP is the leading congress in precision medicine in oncology in Europe, established by key opinion leaders in the field. The name of the Congress was recently changed into Molecular Analysis for Precision Oncology to better reflect its aims of focusing on science, translational research, education and collaboration. This year's event will be held virtually on October 9-10.

About OncoHost

OncoHost combines life-science research and advanced machine learning technology to develop personalized strategies to maximize the success of cancer therapy. Utilizing proprietary proteomic analysis, the company aims to understand patients' unique response to therapy and overcome one of the major obstacles in clinical oncology today resistance to therapy. OncoHost's Host Response Profiling platform (PROphet) analyzes proteomic changes in blood samples to monitor the dynamics of biological processes induced by the patient (i.e., the host) in response to a given cancer therapy. This proteomic profile is highly predictive of individual patient outcome, thus enabling personalized treatment planning. PROphet also identifies potential drug targets, advancing the development of novel therapeutic strategies as well as rationally based combination therapies.

For more information, visithttp://www.oncohost.com

Follow OncoHost onLinkedIn

OncoHost Media Contact: Ellie HansonFinn Partners [emailprotected]+1 929-222-8006

SOURCE OncoHost

https://oncohost.com/

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OncoHost to Present Data on Predicting Host Response to Immunotherapy at the MAP 2020 Virtual Congress - ESMO - PRNewswire

While ride-sharing services like Grab, Uber, and Gojek have become a pervasive part of life, many countries in the Asia Pacific region are still unconvinced when it comes to micro-mobilities such as bike and scooter sharing. While the convenience offered by these is great, especially in this Covid-19 era when people may remain wary of crowding in buses and metro trains, there is a need for in-depth knowledge of these new transportation options to help guide policy and regulation.

A group of scientists in the Senseable City Lab at MIT and the Future Urban Mobility (FM) Interdisciplinary Research Group at the Singapore-MIT Alliance for Research and Technology (SMART), MITs research enterprise in Singapore, set out to better understand the phenomenon and inform policy-making through a comparative analysis of bike-sharing and scooter-sharing activities in Singapore.

The researchers shared their findings in a paper titled Understanding spatio-temporal heterogeneity of bike-sharing and scooter-sharing mobility published in the journal Computers, Environment and Urban Systems. The study is based on real usage records containing location and time of departures and arrivals in two distinct areas in Singapore.

We constructed historical trajectories of the bike-sharing and scooter-sharing trips and compared usage patterns of the two systems at the Marina Bay area and the NUS campus, says Rui Zhu, a postdoc at SMART FM. Our results showed increased sharing frequency and decreased fleet size for scooter-sharing, suggesting that it performs better than bike-sharing.

More specifically, the sharing frequency was increased from less than one time per day for bike-sharing to more than three times per day for scooter-sharing, but the researchers believe that can be improved even further to create a more profitable service.

The study also found that shared scooters in Marina Bay were frequently left away from their designated parking spaces or charging stations, indicating costly and labor-intensive maintenance since employees need to collect and transport scooters between stations continuously. However, the statistics also showed that over 28 percent and 26 percent of trips departed from and arrived at non-stations respectively, suggesting that users actually utilized most of the inappropriately returned scooters.

In addition, the study revealed quantitative changes in trips over time, distances, and duration, and the influence of weather on the demand of micro-mobilities.

In Singapore and a few other cities, dockless bike-sharing systems rose and fell in just one year, followed by an explosion of docking scooter-sharing systems. But we didnt have the necessary insights for appropriate business and policy decisions, Zhu explains. Our study goes deeper into the problems and possibilities of micro-mobility sharing and suggests how these services can be improved.

To facilitate a sustainable scooter-sharing service, the researchers suggest optimizing the fleet size of stations and their locations, regulating returning behaviors more strictly, enabling scooters to have autonomous repositioning functionality, and increasing the useful battery life of scooters.

To increase battery life, they suggest installing a photovoltaic module on scooters for solar charging during trips and parking time or equipping conventional dock-based stations with grid charging or solar charging platforms, allowing for an environmentally friendly solution that will be able to reduce carbon footprints.

While the business model and user behavior greatly impact the success of mobility-sharing services, government policy also plays a significant role. Supportive policies or regulations on controlling fleet sizes and limiting usage to discrete areas are huge drivers for the sustainable development of the new transportation modes. With this study, SMARTs researchers hope to fill existing gaps in knowledge about micro-mobility sharing to help inform policy decisions.

SMART was established by MIT in partnership with the National Research Foundation of Singapore (NRF) in 2007. SMART is the first entity in the Campus for Research Excellence and Technological Enterprise (CREATE) developed by NRF. SMART serves as an intellectual and innovation hub for research interactions between MIT and Singapore, performing cutting-edge research in areas of interest to both. SMART currently comprises an Innovation Center and six Interdisciplinary Research Groups: Future Urban Mobility, Antimicrobial Resistance, BioSystems and Micromechanics, Critical Analytics for Manufacturing Personalized-Medicine, Disruptive and Sustainable Technologies for Agricultural Precision, and Low Energy Electronic Systems.

The Future Urban Mobility group harnesses new technological and institutional innovations to create the next generation of urban mobility systems to increase accessibility, equity, safety, and environmental performance for the citizens and businesses of Singapore and other metropolitan areas, worldwide.

SMART research is supported by the NRF and situated in CREATE.

See more here:
Comparing the benefits of scooter-sharing vs. bike-sharing - MIT News

Oct. 6, 2020 05:30 UTC

STRASBOURG, France & TOKYO & WALTHAM, Mass.--(BUSINESS WIRE)-- Regulatory News:

Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, NEC Corporation (NEC; TSE: 6701), a leader in IT and network technologies and BostonGene Corporation (BostonGene), a biomedical software company committed to defining optimal precision medicine-based therapies for cancer patients, today announced a strategic collaboration for two ongoing Phase 1 clinical trials of TG4050, an individualized therapeutic vaccine for ovarian and head & neck cancers based on Transgenes proprietary myvac platform and NECs AI-driven Neoantigen Prediction System in Europe and the United States.

Transgenes myvac platform brings together a series of highly innovative technologies, such as viral genome engineering, to achieve high-speed modular manufacturing of bespoke immunotherapies.

TG4050 is an individualized cancer vaccine based on the myvac platform; it is based on an optimized viral platform for cancer vaccination and integrates NECs artificial intelligence capabilities. This therapeutic vaccine aims at stimulating the immune system of patients to induce a T-cell response against tumor-specific antigenic alterations, called neoantigens. These neoantigens are derived from genomic mutations and selected using NECs Neoantigen Prediction System, an advanced AI technology that has already been applied in the field of oncology. TG4050 has been designed to target up to 30 patient-specific neoantigens. Transgene is sponsoring two Phase 1 trials that are expected to deliver a first proof of concept of this virus-based individualized approach.

As part of the collaboration, BostonGene will conduct genomic and transcriptomic analyses of primary patient tumors collected from patients enrolled in these two clinical trials to identify predictors of response to TG4050 and the cancer cell-intrinsic and -extrinsic factors that may mediate each patients response to the vaccine. BostonGenes platform integrates the genomic and transcriptomic analyses to simultaneously assess the activity of the tumor and the microenvironment through the identification of significant somatic alterations, evaluation of gene expression, estimation of tumor heterogeneity and classification of the microenvironment.

BostonGene generates a Tumor Portrait Report, involving the data-driven, visually appealing and self-explanatory tumor schematics elegantly depicting tumor activity, tumor cellular composition, and functionality of the immune-microenvironment and other tumor-associated processes. The comprehensive report will provide insights into the individual oncogenic state and immunogenicity of the patients tumor.

BostonGenes unique solution and deep expertise in Next Generation Sequencing (NGS) analysis provide us with the detailed profiles of a tumor and its micro-environment. These Tumor Portrait Reports will help us look at our patient data in light of the current published evidence and could help us accelerate the development of TG4050, said ric Qumneur, Pharm.D., Ph.D., Executive VP, Chief Scientific Officer of Transgene. This novel way of analyzing patient data is part of an ambitious translational program that supports the development of our myvac platform. By integrating these types of approaches into our studies, we seek to build an integrated framework for the use of viral-based immunotherapeutics.

NEC looks forward to strengthening its collaboration with BostonGene through these trials of TG4050. BostonGenes advanced analysis of NGS among cancer patients provides excellent profiling that we believe will add important insight into the understanding of each patients tumor environment and how it reflects on the clinical outcomes of our treatment, said Osamu Fujikawa, Senior Vice President at NEC Corporation.

BostonGene is proud to support Transgene and NEC during these critical Phase 1 clinical trials, said Nathan Fowler, MD, Chief Medical Officer at BostonGene. This collaboration represents our ongoing commitment to improve immunotherapy options and transform personalization of treatment for cancer patients.

About TG4050 TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgenes myvac technology and powered by NECs longstanding artificial intelligence (AI) expertise. This virus-based therapeutic vaccine encodes neoantigens (patient-specific mutations) identified and selected by NECs Neoantigen Prediction System. The prediction system is based on more than two decades of expertise in AI and has been trained on proprietary data allowing it to accurately prioritize and select the most immunogenic sequences.

TG4050 is designed to stimulate the immune system of patients in order to induce a T-cell response that is able to recognize and destroy tumor cells based on their own neoantigens. This individualized immunotherapy is developed for each patient and can be produced in a very short time frame.

This best-in-class candidate is being evaluated in two Phase 1 clinical trials for patients with ovarian cancers (NCT03839524) and HPV-negative head and neck cancers (NCT04183166).

About myvac myvac is a viral vector (MVA) based, individualized immunotherapy platform that has been developed by Transgene to target solid tumors. myvac-derived products are designed to stimulate the patients immune system, recognize and destroy tumors using the patients own cancer specific genetic mutations. Transgene has set up an innovative network that combines bioengineering, digital transformation, established vectorization know-how and unique manufacturing capabilities. Transgene has been awarded Investment for the Future funding from Bpifrance for the development of its platform myvac. TG4050 is the first myvac-derived product being evaluated in clinical trials.

About NEC's Neoantigen Prediction System NEC's neoantigen prediction utilizes its proprietary artificial intelligence (AI), such as graph-based relational learning, which is combined with other sources of data to discover candidate neoantigen targets. NEC comprehensively evaluates the candidate neoantigens with a primary focus placed on its in-house major histocompatibility complex (MHC) binding affinity prediction trained on public and proprietary datasets. These allow NEC to effectively prioritize the numerous candidate neoantigens identified in a single patient.

About Transgene Transgene (Euronext: TNG) is a publicly traded French biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. Transgenes programs utilize viral vector technology with the goal of indirectly or directly killing cancer cells.

The Companys clinical-stage programs consist of two therapeutic vaccines (TG4001 for the treatment of HPV-positive cancers, and TG4050, the first individualized therapeutic vaccine based on the myvac platform) as well as two oncolytic viruses (TG6002 for the treatment of solid tumors, and BT-001, the first oncolytic virus based on the Invir.IO platform).

With Transgenes myvac platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The myvac approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.

With its proprietary platform Invir.IO, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses. Transgene has an ongoing Invir.IO collaboration with AstraZeneca.

Additional information about Transgene is available at: http://www.transgene.fr.

Follow us on Twitter: @TransgeneSA

About NEC Corporation NEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of Orchestrating a brighter world. NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com.

About BostonGene Corporation BostonGene Corporation is pioneering the use of biomedical software for advanced patient analysis and personalized therapy decision making in the fight against cancer. BostonGenes unique solution performs sophisticated analytics to aid clinicians in their evaluation of viable treatment options for each patient's individual genetics, tumor and tumor microenvironment, clinical characteristics and disease profile. BostonGenes mission is to enable physicians to provide every patient with the highest probability of survival through optimal cancer treatments using advanced, personalized therapies. For more information, visit BostonGene at http://www.BostonGene.com.

Transgene disclaimer This press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Companys activities, perspectives, financial situation, results, regulatory authorities agreement with development phases, and development. The Companys ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Companys actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (Facteurs de Risque) section of the Universal Registration Document, available on the AMF website (http://www.amf-france.org) or on Transgenes website (www.transgene.fr). Forward-looking statements speak only as of the date on which they are made and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future.

View source version on businesswire.com: https://www.businesswire.com/news/home/20201005005838/en/

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Transgene, NEC and BostonGene Announce Strategic Collaboration for Two Ongoing Clinical Trials for Patients with Ovarian and Head & Neck Cancers -...

The treatment given to POTUS is the abstraction we all desire personalized medicine. Just the right treatment, at the right time, in the right way. Of course, physicians' day-to-day dilemma is translating guidelines and treatments tested upon populations into efficacious care for the individual sitting across from your desk. And that dilemma is compounded when you deal with VIPs

It is not March; when the virus didn't respond to the treatments that had always worked so well for influenza - we threw everything we had at the problem. While we have made significant progress in treating COVID-19, I do not believe we have a set-in-place protocol for what to do when. There is a broad outline of medications that may reduce symptoms, improve outcomes, and reduce the length of stay lots of ingredients, lots of chefs, but no classic recipe.

All of the medications that the President has been publically acknowledged as receiving reduce symptoms.

Ethical medicine, "shared decision making" between patient and physician requires that I provide you with options, state which I feel is the best approach and why, and together we choose a path forward. The President's care, as with most VIPs, involves lots of chefs. Many chefs with nuanced opinions that by consensus, majority vote, or eminence eventually become a treatment plan. [1] One of the difficulties in treating VIPs, in general, is that in many instances, they believe their eminence extends to being a chef too. They can be very "hands-on" when it comes to choosing treatments and what to pursue.

The patient applies any factors they feel are relevant in that calculus. I think it is apparent that the President has included a political component to his choices. This is not the time to appear weak physically or emotionally. His motorcade to his supporters is an example of powerful eminence in action. As a rule, hospitals don't allow you to leave for a few hours and return; in many cases, chronic smokers with significant addiction to nicotine are not allowed to go outside for a cigarette.

Of course, it takes two to make a medical decision; you still need a physician. Can we reasonably believe that the phrase "an abundance of caution" has not impacted their clinical judgment? Additionally, by my count, the President has had at least three physicians, including his private one, since taking office. The idea that he has a deep enough long-term relationship with any of them that would allow for considered choice is silly; in that way, the President echoes some of our behavior, honoring primary care in word but not deed.

Words matter and their meaningvariessignificantly from one context to another. Consider Chris Christie, who "checked himself in" to a hospital over the weekend. Hospitals are not hotels; you don't check-in; you are admitted to the hospital by an attending physician who has determined you have met the admission criteria. You only would describe admission to the hospital as checking-in to make it seem more an optional vacation choice, less a medical need.

Or the announcement that the President may go home to continue care, you shouldn't take that to mean he is like a typical COVID-19 patient being discharged from the hospital; unless, of course, that patient has a fully equipped Emergency Department and physicians standing by in their home.

It is a fool's errand to guess at the President's clinical status based on his receiving treatment. Whether he received supplemental oxygen doesn't necessarily mean he was more ill or that the doctors acted out of an abundance of caution. What is supplemental oxygen, 2 liters/min or 8, nasal prongs, or face mask? We cannot tell.

He is receiving personalized care, not care from some guidelines that haven't even been formulated. His treatment, like ours, is or should be, is personalized to his needs. It may very well be that his perception of his non-medical needs overrides his physicians' medical judgment, but that is a problem all doctors and patients face.

[1] One of the problems for VIPS is that, in some cases, "too many cooks do spoil the soup." If you don't believe me take a look at themedical decisionssurrounding President Garfield, "At least a dozen medical experts probed the president's wound, often with unsterilized metal instruments or bare hands, as was common at the time." Or look at thecare of the Shah of Iran, whose cancer was treated by the world's best cardiac surgeon, with a very poor outcome.

Read more:
Managing the President's COVID-19 - American Council on Science and Health

A new modeling tool may be able to help doctors assess which treatments are best for individual patients with colorectal cancer. The artificial intelligence program analyzes a patient's disease details -- such as the stage of cancer and other chronic conditions -- and compares those details to other colorectal cancer cases to predict the patient's chance of surviving past 10 years.

"Predicting survival of cancer patients as a means to help determine treatments is not new," said Jean Emmanuel Bibault, MD, PhD, a radiation oncologist who led the study. "But current standard techniques are not very accurate, and we're hoping that by using AI we can bring more precise information to doctors as they make crucial decisions about care."

Predicting a cancer patient's survival time lends valuable insight into the best course of treatment for both the long and short term, helping to determine what is likely most suitable.

The online tool works by assessing 32 details about an individual patient, such as age, the stage of the cancer, exercise habits, cholesterol levels, history of chronic disease and much more.

After these details are input into the tool, the algorithm predicts how long that person might live and reports a number in years. The tool also provides context, citing the top reasons for its calculation, such as the stage of the cancer, the patient's age at diagnosis, or how the patient was initially treated.

"From a physician's point of view, we want to know how well our patients are going to do from the get-go. We're looking at two main things: how to choose the right therapy, and if we can alter their destiny," said Daniel Chang, MD, professor of radiation oncology, who is an author of the study.

"Some folks have a bit of a nihilistic point of view," he continued, "that survival is determined by the genetics of your cancer and of your body. But the question is: Can anything we, as doctors, do change that outcome if we do it sooner or do it differently from the start? That's where I see a lot of value for this research."

An abstract on the research appeared online inGut.

Bibault, Chang and professor of radiation oncology, Lei Xing, PhD, devised the algorithm powering the prediction tool with data made available through the National Institutes of Health, from thousands of de-identified patients who have or had colorectal cancer at various stages and are of varying ages.

The team trained the algorithm to track survival of thousands of patients, in conjunction with the details of their disease and some details about their course of treatment. In this way, the algorithm uses the outcomes and survival rates of past cohorts to calculate the chance of survival for future patients.

So far, the tool has been about 90% accurate in predictions it made on 472 patient cases that were not used to train the tool. The tool has not been used in a clinical setting.

"The treatments that we have nowadays are becoming more and more specialized, targeted, in many cases intensified. And the reality is that not everybody is going to benefit from new treatments, therapies or technologies in the same way," said Chang.

"This algorithm could allow us a better shot at personalized medicine, and enhance our ability to tailor the treatments to be as appropriate as possible," he added.

Although patients could use the tool on their own, Bibault said the ideal application would be for doctors and patients to use the tool together. That way, doctors would be able to contextualize the result and answer any patient questions.

The team's goal is to enhance the algorithm's accuracy and to find other applications for it.

"We have laid the foundation for this model," said Bibault, "and we're hopeful it can apply to other cancer types as well."

Photo by National Cancer Institute

Read more:
AI tool created to guide colorectal cancer care with more precision - Scope

LONDON--(BUSINESS WIRE)--Technavio has been monitoring the clinical mass spectrometry market and it is poised to grow by USD 1.70 billion during 2020-2024, progressing at a CAGR of almost 6% during the forecast period. The report offers an up-to-date analysis regarding the current market scenario, latest trends and drivers, and the overall market environment.

To learn more about the global trends impacting the future of market research, download a free sample: https://www.technavio.com/talk-to-us?report=IRTNTR44340

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Although the COVID-19 pandemic continues to transform the growth of various industries, the immediate impact of the outbreak is varied. While a few industries will register a drop in demand, numerous others will continue to remain unscathed and show promising growth opportunities. Technavios in-depth research has all your needs covered as our research reports include all foreseeable market scenarios, including pre- & post-COVID-19 analysis. Download a Free Sample Report on COVID-19 Impacts

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The market is fragmented, and the degree of fragmentation will accelerate during the forecast period. Agilent Technologies Inc., Bruker Corp., Danaher Corp., Hitachi Ltd., JEOL Ltd., Kore Technology Ltd., PerkinElmer Inc., Shimadzu Corp., Thermo Fisher Scientific Inc., and Waters Corp. are some of the major market participants. The rise in geriactric population will offer immense growth opportunities. To make most of the opportunities, market vendors should focus more on the growth prospects in the fast-growing segments, while maintaining their positions in the slow-growing segments.

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Technavio's custom research reports offer detailed insights on the impact of COVID-19 at an industry level, a regional level, and subsequent supply chain operations. This customized report will also help clients keep up with new product launches in direct & indirect COVID-19 related markets, upcoming vaccines and pipeline analysis, and significant developments in vendor operations and government regulations.

Clinical Mass Spectrometry Market 2020-2024: Segmentation

Clinical Mass Spectrometry Market is segmented as below:

Clinical Mass Spectrometry Market 2020-2024: Scope

Technavio presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources. The clinical mass spectrometry market report covers the following areas:

This study identifies increasing demand for clinical mass spectrometry in personalized medicine as one of the prime reasons driving the clinical mass spectrometry market growth during the next few years.

Technavio suggests three forecast scenarios (optimistic, probable, and pessimistic) considering the impact of COVID-19. Technavios in-depth research has direct and indirect COVID-19 impacted market research reports.

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Clinical Mass Spectrometry Market 2020-2024: Key Highlights

Table of Contents:

Executive Summary

Market Landscape

Market Sizing

Five Forces Analysis

Market Segmentation by End-user

Customer landscape

Geographic Landscape

Vendor Landscape

Vendor Analysis

Appendix

About Us

Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavios report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavios comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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Clinical Mass Spectrometry Market by End-User (Healthcare Facilities and Pharma and Biotech Companies and Research Labs and Institutes) and Geography...

Researchers from Critical Analytics for Manufacturing Personalized-Medicine (CAMP), an interdisciplinary research group at Singapore-MIT Alliance for Research and Technology (SMART), MITs research enterprise in Singapore, have been awarded Intra-CREATE grants from the National Research Foundation (NRF) Singapore to help support research on retinal biometrics for glaucoma progression and neural cell implantation therapy for spinal cord injuries. The grants are part of the NRFs initiative to bring together researchers from Campus for Research Excellence And Technological Enterprise (CREATE) partner institutions, in order to achieve greater impact from collaborative research efforts.

SMART CAMP was formed in 2019 to focus on ways to produce living cells as medicine delivered to humans to treat a range of illnesses and medical conditions, including tissue degenerative diseases, cancer, and autoimmune disorders.

Singapores well-established biopharmaceutical ecosystem brings with it a thriving research ecosystem that is supported by skilled talents and strong manufacturing capabilities. We are excited to collaborate with our partners in Singapore, bringing together an interdisciplinary group of experts from MIT and Singapore, for new research areas at SMART. In addition to our existing research on our three flagship projects, we hope to develop breakthroughs in manufacturing other cell therapy platforms that will enable better medical treatments and outcomes for society, says Krystyn Van Vliet, co-lead principal investigator at SMART CAMP, professor of materials science and engineering, and associate provost at MIT.

Understanding glaucoma progression for better-targeted treatments

Hosted by SMART CAMP, the first research project, Retinal Analytics via Machine learning aiding Physics (RAMP), brings together an interdisciplinary group of ophthalmologists, data scientists, and optical scientists from SMART, Singapore Eye Research Institute (SERI), Agency for Science, Technology and Research (A*STAR), Duke-NUS Medical School, MIT, and National University of Singapore (NUS). The team will seek to establish first principles-founded and statistically confident models of glaucoma progression in patients. Through retinal biomechanics, the models will enable rapid and reliable forecast of the rate and trajectory of glaucoma progression, leading to better-targeted treatments.

Glaucoma, an eye condition often caused by stress-induced damage over time at the optic nerve head, accounts for 5.1 million of the estimated 38 million blind in the world and 40 percent of blindness in Singapore. Currently, health practitioners face challenges forecasting glaucoma progression and its treatment strategies due to the lack of research and technology that accurately establish the relationship between its properties, such as the elasticity of the retina and optic nerve heads, blood flow, intraocular pressure and, ultimately, damage to the optic nerve head.

The research is co-led by George Barbastathis, principal investigator at SMART CAMP and professor of mechanical engineering at MIT, and Aung Tin, executive director at SERI and professor at the Department of Ophthalmology at NUS. The team includes CAMP principal investigators Nicholas Fang, also a professor of mechanical engineering at MIT; Lisa Tucker-Kellogg, assistant professor with the Cancer and Stem Biology program at Duke-NUS; and Hanry Yu, professor of physiology with the Yong Loo Lin School of Medicine, NUS and CAMPs co-lead principal investigator.

We look forward to leveraging the ideas fostered in SMART CAMP to build data analytics and optical imaging capabilities for this pressing medical challenge of glaucoma prediction, says Barbastathis.

Cell transplantation to treat irreparable spinal cord injury

Engineering Scaffold-Mediated Neural Cell Therapy for Spinal Cord Injury Treatment (ScaNCellS), the second research project, gathers an interdisciplinary group of engineers, cell biologists, and clinician scientists from SMART, Nanyang Technological University (NTU), NUS, IMCB A*STAR, A*STAR, French National Centre for Scientific Research (CNRS), the University of Cambridge, and MIT. The team will seek to design a combined scaffold and neural cell implantation therapy for spinal cord injury treatment that is safe, efficacious, and reproducible, paving the way forward for similar neural cell therapies for other neurological disorders. The project, an intersection of engineering and health, will achieve its goals through an enhanced biological understanding of the regeneration process of nerve tissue and optimized engineering methods to prepare cells and biomaterials for treatment.

Spinal cord injury (SCI), affecting between 250,00 and 500,000 people yearly, is expected to incur higher societal costs as compared to other common conditions such as dementia, multiple sclerosis, and cerebral palsy. SCI can lead to temporary or permanent changes in spinal cord function, including numbness or paralysis. Currently, even with the best possible treatment, the injury generally results in some incurable impairment.

The research is co-led by Chew Sing Yian, principal investigator at SMART CAMP and associate professor of the School of Chemical and Biomedical Engineering and Lee Kong Chian School of Medicine at NTU, and Laurent David, professor at University of Lyon (France) and leader of the Polymers for Life Sciences group at CNRS Polymer Engineering Laboratory. The team includes CAMP principal investigators Ai Ye from Singapore University of Technology and Design; Jongyoon Han and Zhao Xuanhe, both professors at MIT; as well as Shi-Yan Ng and Jonathan Loh from Institute of Molecular and Cell Biology, A*STAR.

Chew says, Our earlier SMART and NTU scientific collaborations on progenitor cells in the central nervous system are now being extended to cell therapy translation. This helps us address SCI in a new way, and connect to the methods of quality analysis for cells developed in SMART CAMP.

Cell therapy, one of the fastest-growing areas of research, will provide patients with access to more options that will prevent and treat illnesses, some of which are currently incurable. Glaucoma and spinal cord injuries affect many. Our research will seek to plug current gaps and deliver valuable impact to cell therapy research and medical treatments for both conditions. With a good foundation to work on, we will be able to pave the way for future exciting research for further breakthroughs that will benefit the health-care industry and society, says Hanry Yu, co-lead principal investigator at SMART CAMP, professor of physiology with the Yong Loo Lin School of Medicine, NUS, and group leader of the Institute of Bioengineering and Nanotechnology at A*STAR.

The grants for both projects will commence on Oct. 1, with RAMP expected to run until Sept. 30, 2022, and ScaNCellS expected to run until Sept. 30, 2023.

SMART was. established by the MIT in partnership with the NRF in 2007. SMART is the first entity in the CREATE developed by NRF. SMART serves as an intellectual and innovation hub for research interactions between MIT and Singapore, undertaking cutting-edge research projects in areas of interest to both Singapore and MIT. SMART currently comprises an Innovation Centre and five interdisciplinary research groups (IRGs): Antimicrobial Resistance, CAMP, Disruptive and Sustainable Technologies for Agricultural Precision, Future Urban Mobility, and Low Energy Electronic Systems.

CAMP is a SMART IRG launched in June 2019. It focuses on better ways to produce living cells as medicine, or cellular therapies, to provide more patients access to promising and approved therapies. The investigators at CAMP address two key bottlenecks facing the production of a range of potential cell therapies: critical quality attributes (CQA) and process analytic technologies (PAT). Leveraging deep collaborations within Singapore and MIT in the United States, CAMP invents and demonstrates CQA/PAT capabilities from stem to immune cells. Its work addresses ailments ranging from cancer to tissue degeneration, targeting adherent and suspended cells, with and without genetic engineering.

CAMP is the R&D core of a comprehensive national effort on cell therapy manufacturing in Singapore.

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SMART researchers receive Intra-CREATE grant for personalized medicine and cell therapy - MIT News

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Moreover, the Personalized Medicine report describes the market division based on various parameters and attributes that are based on geographical distribution, product types, applications, etc. The market segmentation clarifies further regional distribution for the Personalized Medicine market, business trends, potential revenue sources, and upcoming market opportunities.

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Key players in the global Personalized Medicine market covered in Chapter 4:Amgen Inc.GE HealthcareSiemens Healthcare Diagnostics Inc.Asuragen IncQiagen Inc.Becton Dickinson & Co.Agendia NVPfizer Inc.Bristol-Myers SquibbAbbott

In Chapter 11 and 13.3, on the basis of types, the Personalized Medicine market from 2015 to 2026 is primarily split into:PM DiagnosticsPM TherapeuticsPersonalized Medical CarePersonalized Nutrition & Wellness

In Chapter 12 and 13.4, on the basis of applications, the Personalized Medicine market from 2015 to 2026 covers:Diagnosis and interventionDrug development and usageCancer genomics

Geographically, the detailed analysis of consumption, revenue, market share and growth rate, historic and forecast (2015-2026) of the following regions are covered in Chapter 5, 6, 7, 8, 9, 10, 13:North America (Covered in Chapter 6 and 13)United StatesCanadaMexicoEurope (Covered in Chapter 7 and 13)GermanyUKFranceItalySpainRussiaOthersAsia-Pacific (Covered in Chapter 8 and 13)ChinaJapanSouth KoreaAustraliaIndiaSoutheast AsiaOthersMiddle East and Africa (Covered in Chapter 9 and 13)Saudi ArabiaUAEEgyptNigeriaSouth AfricaOthersSouth America (Covered in Chapter 10 and 13)BrazilArgentinaColumbiaChileOthers

The Personalized Medicine market study further highlights the segmentation of the Personalized Medicine industry on a global distribution. The report focuses on regions of North America, Europe, Asia, and the Rest of the World in terms of developing business trends, preferred market channels, investment feasibility, long term investments, and environmental analysis. The Personalized Medicine report also calls attention to investigate product capacity, product price, profit streams, supply to demand ratio, production and market growth rate, and a projected growth forecast.

In addition, the Personalized Medicine market study also covers several factors such as market status, key market trends, growth forecast, and growth opportunities. Furthermore, we analyze the challenges faced by the Personalized Medicine market in terms of global and regional basis. The study also encompasses a number of opportunities and emerging trends which are considered by considering their impact on the global scale in acquiring a majority of the market share.

The study encompasses a variety of analytical resources such as SWOT analysis and Porters Five Forces analysis coupled with primary and secondary research methodologies. It covers all the bases surrounding the Personalized Medicine industry as it explores the competitive nature of the market complete with a regional analysis.

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Some Point of Table of Content:

Chapter One: Report Overview

Chapter Two: Global Market Growth Trends

Chapter Three: Value Chain of Personalized Medicine Market

Chapter Four: Players Profiles

Chapter Five: Global Personalized Medicine Market Analysis by Regions

Chapter Six: North America Personalized Medicine Market Analysis by Countries

Chapter Seven: Europe Personalized Medicine Market Analysis by Countries

Chapter Eight: Asia-Pacific Personalized Medicine Market Analysis by Countries

Chapter Nine: Middle East and Africa Personalized Medicine Market Analysis by Countries

Chapter Ten: South America Personalized Medicine Market Analysis by Countries

Chapter Eleven: Global Personalized Medicine Market Segment by Types

Chapter Twelve: Global Personalized Medicine Market Segment by Applications12.1 Global Personalized Medicine Sales, Revenue and Market Share by Applications (2015-2020)12.1.1 Global Personalized Medicine Sales and Market Share by Applications (2015-2020)12.1.2 Global Personalized Medicine Revenue and Market Share by Applications (2015-2020)12.2 Diagnosis and intervention Sales, Revenue and Growth Rate (2015-2020)12.3 Drug development and usage Sales, Revenue and Growth Rate (2015-2020)12.4 Cancer genomics Sales, Revenue and Growth Rate (2015-2020)

Chapter Thirteen: Personalized Medicine Market Forecast by Regions (2020-2026) continued

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List of tablesList of Tables and FiguresTable Global Personalized Medicine Market Size Growth Rate by Type (2020-2026)Figure Global Personalized Medicine Market Share by Type in 2019 & 2026Figure PM Diagnostics FeaturesFigure PM Therapeutics FeaturesFigure Personalized Medical Care FeaturesFigure Personalized Nutrition & Wellness FeaturesTable Global Personalized Medicine Market Size Growth by Application (2020-2026)Figure Global Personalized Medicine Market Share by Application in 2019 & 2026Figure Diagnosis and intervention DescriptionFigure Drug development and usage DescriptionFigure Cancer genomics DescriptionFigure Global COVID-19 Status OverviewTable Influence of COVID-19 Outbreak on Personalized Medicine Industry DevelopmentTable SWOT AnalysisFigure Porters Five Forces AnalysisFigure Global Personalized Medicine Market Size and Growth Rate 2015-2026Table Industry NewsTable Industry PoliciesFigure Value Chain Status of Personalized MedicineFigure Production Process of Personalized MedicineFigure Manufacturing Cost Structure of Personalized MedicineFigure Major Company Analysis (by Business Distribution Base, by Product Type)Table Downstream Major Customer Analysis (by Region)Table Amgen Inc. ProfileTable Amgen Inc. Production, Value, Price, Gross Margin 2015-2020Table GE Healthcare ProfileTable GE Healthcare Production, Value, Price, Gross Margin 2015-2020Table Siemens Healthcare Diagnostics Inc. ProfileTable Siemens Healthcare Diagnostics Inc. Production, Value, Price, Gross Margin 2015-2020Table Asuragen Inc ProfileTable Asuragen Inc Production, Value, Price, Gross Margin 2015-2020Table Qiagen Inc. ProfileTable Qiagen Inc. Production, Value, Price, Gross Margin 2015-2020Table Becton Dickinson & Co. ProfileTable Becton Dickinson & Co. Production, Value, Price, Gross Margin 2015-2020Table Agendia NV ProfileTable Agendia NV Production, Value, Price, Gross Margin 2015-2020Table Pfizer Inc. ProfileTable Pfizer Inc. Production, Value, Price, Gross Margin 2015-2020Table Bristol-Myers Squibb ProfileTable Bristol-Myers Squibb Production, Value, Price, Gross Margin 2015-2020Table Abbott ProfileTable Abbott Production, Value, Price, Gross Margin 2015-2020Figure Global Personalized Medicine Sales and Growth Rate (2015-2020)Figure Global Personalized Medicine Revenue ($) and Growth (2015-2020)Table Global Personalized Medicine Sales by Regions (2015-2020)Table Global Personalized Medicine Sales Market Share by Regions (2015-2020)Table Global Personalized Medicine Revenue ($) by Regions (2015-2020)Table Global Personalized Medicine Revenue Market Share by Regions (2015-2020)Table Global Personalized Medicine Revenue Market Share by Regions in 2015Table Global Personalized Medicine Revenue Market Share by Regions in 2019Figure North America Personalized Medicine Sales and Growth Rate (2015-2020)Figure Europe Personalized Medicine Sales and Growth Rate (2015-2020)Figure Asia-Pacific Personalized Medicine Sales and Growth Rate (2015-2020)Figure Middle East and Africa Personalized Medicine Sales and Growth Rate (2015-2020)Figure South America Personalized Medicine Sales and Growth Rate (2015-2020)Figure North America Personalized Medicine Revenue ($) and Growth (2015-2020)Table North America Personalized Medicine Sales by Countries (2015-2020)Table North America Personalized Medicine Sales Market Share by Countries (2015-2020)Figure North America Personalized Medicine Sales Market Share by Countries in 2015Figure North America Personalized Medicine Sales Market Share by Countries in 2019Table North America Personalized Medicine Revenue ($) by Countries (2015-2020)Table North America Personalized Medicine Revenue Market Share by Countries (2015-2020)Figure North America Personalized Medicine Revenue Market Share by Countries in 2015Figure North America Personalized Medicine Revenue Market Share by Countries in 2019Figure United States Personalized Medicine Sales and Growth Rate (2015-2020)Figure Canada Personalized Medicine Sales and Growth Rate (2015-2020)Figure Mexico Personalized Medicine Sales and Growth (2015-2020)Figure Europe Personalized Medicine Revenue ($) Growth (2015-2020)Table Europe Personalized Medicine Sales by Countries (2015-2020)Table Europe Personalized Medicine Sales Market Share by Countries (2015-2020)Figure Europe Personalized Medicine Sales Market Share by Countries in 2015Figure Europe Personalized Medicine Sales Market Share by Countries in 2019Table Europe Personalized Medicine Revenue ($) by Countries (2015-2020)Table Europe Personalized Medicine Revenue Market Share by Countries (2015-2020)Figure Europe Personalized Medicine Revenue Market Share by Countries in 2015Figure Europe Personalized Medicine Revenue Market Share by Countries in 2019Figure Germany Personalized Medicine Sales and Growth Rate (2015-2020)Figure UK Personalized Medicine Sales and Growth Rate (2015-2020)Figure France Personalized Medicine Sales and Growth Rate (2015-2020)Figure Italy Personalized Medicine Sales and Growth Rate (2015-2020)Figure Spain Personalized Medicine Sales and Growth Rate (2015-2020)Figure Russia Personalized Medicine Sales and Growth Rate (2015-2020)Figure Asia-Pacific Personalized Medicine Revenue ($) and Growth (2015-2020)Table Asia-Pacific Personalized Medicine Sales by Countries (2015-2020)Table Asia-Pacific Personalized Medicine Sales Market Share by Countries (2015-2020)Figure Asia-Pacific Personalized Medicine Sales Market Share by Countries in 2015Figure Asia-Pacific Personalized Medicine Sales Market Share by Countries in 2019Table Asia-Pacific Personalized Medicine Revenue ($) by Countries (2015-2020)Table Asia-Pacific Personalized Medicine Revenue Market Share by Countries (2015-2020)Figure Asia-Pacific Personalized Medicine Revenue Market Share by Countries in 2015Figure Asia-Pacific Personalized Medicine Revenue Market Share by Countries in 2019Figure China Personalized Medicine Sales and Growth Rate (2015-2020)Figure Japan Personalized Medicine Sales and Growth Rate (2015-2020)Figure South Korea Personalized Medicine Sales and Growth Rate (2015-2020)Figure Australia Personalized Medicine Sales and Growth Rate (2015-2020)Figure India Personalized Medicine Sales and Growth Rate (2015-2020)Figure Southeast Asia Personalized Medicine Sales and Growth Rate (2015-2020)Figure Middle East and Africa Personalized Medicine Revenue ($) and Growth (2015-2020) continued

About HongChun Research:HongChun Research main aim is to assist our clients in order to give a detailed perspective on the current market trends and build long-lasting connections with our clientele. Our studies are designed to provide solid quantitative facts combined with strategic industrial insights that are acquired from proprietary sources and an in-house model.

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NOTE: Our report does take into account the impact of coronavirus pandemic and dedicates qualitative as well as quantitative sections of information within the report that emphasizes the impact of COVID-19.

As this pandemic is ongoing and leading to dynamic shifts in stocks and businesses worldwide, we take into account the current condition and forecast the market data taking into consideration the micro and macroeconomic factors that will be affected by the pandemic.

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When people find out Azizi Seixas studies sleep, they sometimes ask him about their dreams. Thats not really his fieldbut he does have big dreams for his own research. By using technology to combine precision medicine with population-level research, he hopes to erase disparities and bring better health to all.

Growing up in inner-city Kingston, Jamaica, I was the have-nots, Seixas says. He learned early lessons about inequality andbeing raised by seven women in a three-bedroom homeresourcefulness. Today hes carried those lessons to New York Universitys Grossman School of Medicine, where hes an assistant professor of population health and psychiatry. In his lab, Seixas explores why certain groups such as racial and ethnic minorities have higher risks of chronic illnesses, the long-term consequences of those disparities, and how people can change their behavior to improve their health.

Sleep has been a kind of lens through which Seixas looks at these questions. For example, how are disparities in peoples sleep related to heart disease risk and other health effects? And how might doctors tailor sleep advice to individuals, along with their other recommendations?

Thats important because sleep plays an integral role in our health 24/7, not just the hours were in bed. Sleep is not just the act of unconsciousness, Seixas says. Besides keeping our bodies refreshed and running, sleep is important for consolidating things weve learned, and for cleansing our brains of protein gunk thats linked to Alzheimers disease.

Yet not everyone can get as much sleep as they need. He gives the example of a single mother who works two jobs. If he tells her she needs to sleep eight or nine hours a night, Shell look at me and scoff, Seixas says. And they have, to be quite honest.

Seixas imagines working with that single mom to figure out ways to offset her lost sleep using other health recommendations. Maybe dialing up her exercise can lower her risk of certain diseases, even while she continues squeezing in just six hours a night. If exercising more isnt feasible, maybe she can adjust her diet instead. The data to make this happen might come from wearable technologies that track the moms activities and biometrics, as well as artificial intelligence and machine-learning models that predict how changes to her behaviors will affect her health.

Scientists are still learning about the intricate ways our traits, behaviors, and risks may affect each other, so this scenario is still hypothetical. But one goal of Seixass research is to be able to personalize the advice a doctor gives a patient, rather than assuming that the same guidance is right for everybody. Seixas calls his philosophy precision and personalized population health. He thinks general guidelines for the public are important, too. But to fulfill what he calls his sacrosanct role in public health, he wants to find precisely the right way to help that single mother, or anyone else, stay healthy.

How is their nightly sleep related to their daily steps?

Some of his research hints that it might be possible. In a 2018 paper, he and his colleagues used machine learning to analyze survey data from more than 280,000 people about whether theyd had a stroke, as well as their age, sex, nightly sleep, and physical activity. The analysis showed which combinations of factors put people at higher or lower risk of strokes. In a similar 2017 paper, Seixas and others calculated which combinations of activity, sleep, stress, and body mass index were linked to the lowest diabetes risk in Black and white Americans.

The more health data he can include from a diverse range of people, the better the recommendations that might emerge from it. Among many other projects to help improve these datasets, Seixas is soon launching a study with funding from Merck that will focus on people with hypertension and diabetes. Seixas and his team created an app that will give participants higher-level analyses from the Fitbits or other health trackers they already use. For example, how is their nightly sleep related to their daily steps? The app will also automatically gather health-related news and articles that might interest the user. And, critically, it will tell users about clinical trials they can enroll in. We want to appeal to the greater good of individuals, Seixas says, tapping into peoples drive for altruism and volunteering to fight chronic health conditions.

Encouraging more people to enroll in clinical trialswhich include trials of behavioral changes, not just tests of new drugscould help researchers get better data on underrepresented groups. Seixas hopes it could also help the public to see science in a positive light. Especially now, he says, where you have political figures questioning whether or not science should be the bright force that it has always been.

Seixass ideas are especially timely during COVID-19, says Girardin Jean-Louis, a professor of population health and psychiatry at NYU Langone Health, who is Seixass mentor. During the pandemic, vulnerable communities are having an especially hard time accessing healthcare. His research is poised to address how various health issues plaguing underserved communities can be addressed adequately, Jean-Louis says.

Seixas hopes the questions he and his research group at NYU are asking will someday help to transform healthcare. We have very ambitious dreams and goals, he says.

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Big Dreams of Personalized Health - NEO.LIFE

SAN ANTONIO, Oct. 1, 2020 /PRNewswire/ --Innovative Gx Laboratories, a Texas-based molecular diagnostic company, is announcing the grand opening of its central testing laboratory in San Antonio, Texas, on Oct. 1, 2020. Innovative Gx specializes in molecular diagnosis using real-time RT PCR and DNA sequencing in many medical areas. The company is a leader in personalized medical solutions such as Respiratory Pathogens, Infectious Disease, COVID-19, and DNA-based Pharmacogenetics (PGX) testing services delivering genetic-based treatment of patient care.

Innovative Gx Laboratories was founded in 2019by a team of careermedical diagnostic scientists with a combined 30+ years of experience. Its scientific team is dedicated to providing the highest-quality clinical testing services to help people reach the best health through personalized medicine. The company offers high-accuracy testing, ship-to-home (reviewed by an independent physician) or B2B solutions, offering diagnostic kitsand rapid results (often delivered in as little as less than 24 hours) for its physicians, hospitals, and clinics it serves nationwide.

Innovative Gx Laboratories provides one of the most comprehensive molecular testing options for physicians to help them accurately diagnose and treat many diseases through its targeted pharmacogenomic (PGX) panels. At present, Innovative Gx PGX panels include medications commonly prescribed to treat cardiovascular disease, mental health, infectious disease, cancer, and adverse drug interactions, and examineover 62 genes and 200 gene variants.

Innovative GX Laboratories also specializes in molecular testing of infectious disease, identification of a large range of respiratory pathogens, and RT PCR-based COVID testing. The Innovative Gx RT PCR COVID-19 Test is considered the "gold standard" in COVID screening and has received FDA authorization for emergency use. The test's level of accuracy is much higher than antigen and antibody testing and attains 99% determination of virus present.

"Our team of scientists and physicians at Innovative Gx Laboratories work diligently to offer the most comprehensive testing panels for our hospitals, physicians, and patients," said Enrique Perez-Paris, one of the co-founders of the company. He added, "Innovative Gx is much more than a business venture. It is my legacy, allowing the team at IG, to help others by providing precise health information in an accurate and timely manner."

For more information about Innovative Gx Laboratories and details of its services, please visit or contact the company at:

Innovative Gx Laboratories5410 Fredericksburg Road, Suite A304, San Antonio, Texas 78229(866) 3PCR-DNA[emailprotected] https://innovativegx.com

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Innovative Gx Laboratories Announces the Grand Opening of Its Molecular Diagnostic Laboratory in Texas - PRNewswire

The Nobel Prizes for Physics, Chemistry and Medicine are the acme of scientific achievement -- honoring great minds and life-changing discoveries. But predicting who will be summoned to Stockholm and win the accolades, which are announced next week, is easy to get wrong.

That doesn't mean that people don't try.

Some look at which scientists have won so-called predictor prizes like the Lasker Awards for medical science, others analyze the fields of study favored by the Nobel Committee and tally how many years pass before a specific field is honored.

Complicating matters is that the Nobel selection committee, according to the rules laid down by Swedish industrialist Alfred Nobel in 1895, can only honor up to three people -- something that is getting harder given the collaborative nature of much scientific research.

Pandemic medicine

Unlike the peace prize, which often raises some eyebrows, the science prizes tend to honor achievements that have withstood the test of time -- last year's prize in chemistry recognized research in the development of lithium batteries from the 1980s that included honoring the oldest winner ever. The distinctions in science are thus less likely to generate controversy.

This means that it's highly unlikely that the fast-moving scientific research into Covid-19 will be featured, although many think that a drug to treat the disease or vaccine to stop its spread is a potential future winner.

That said, Gilbert Thompson, professor emeritus of clinical lipidology at Imperial College London, thinks that the committee could honor two scientists, Max Cooper and Jacques Miller, whose discovery about the organization and function of the human immune system, in particular B cells and T cells, is underpinning vaccine research.

Eman Ghanem, membership director at Sigma Xi, a global association of around 30,000 scientists that includes some 200 Nobel prize winners, is hopeful that there will be a female Nobel Laureate in science after an all-male lineup in 2019.

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Citations

David Pendlebury, a senior citation analyst at Clarivate Analytics, since 2002 has made 54 correct predictions (though not usually in the right year) by analyzing how often a scientist's key papers are cited by peers. Out of some 50 million scientific papers indexed since 1970, only 5,700 (or 0.01%) have been cited 2,000 or more times, and this is the pool from which his prediction are drawn.

"We're not saying that these particular people are going to win in a particular year," Pendlebury said. "We're saying these people are Nobel class and are likely to win a Nobel prize at some point.

For the physics prize, one of three contending groups Pendlebury lists is Carlos Frenk of Durham University, Julio Navarro of University of Victoria in Canada and Simon White, former director at the Max Planck Institute for Astrophysics, for their work into galaxy formation, cosmic structure and dark matter. However, Pendlebury said a win this year is unlikely because last year's physics prize for the first discovery of planets outside our solar system, led by Princeton astrophysicist James Peebles, was from the same field.

"It's highly cited, essential work, but I think it will probably be a few years till they return to a prize in cosmology," he said. "Though they could prove me wrong."

Conservative choices

The CRISPR gene-editing technology, is often mentioned as a candidate for the chemistry prize, but Pendlebury said it was a potential minefield for a Nobel Committee that likes to play it safe.

While worthy, he said several groups of scientists have been collaborating on gene editing, making it hard to narrow it down to three names. Moreover, the technology had until recently been tied up in patent wrangles. (And that's notwithstanding the ethical concerns that have dogged the technology in the wake of Chinese scientist He Jiankui, who was jailed for creating the world's first gene-edited babies.)

"I think they are making conservative choices on the significance of the science," he said.

For medicine, Pendlebury's picks include Yusuke Nakamura, a Japanese geneticist, whose contributions in pioneering whole genome sequencing gave birth to the field of personalized medicine that has revolutionized cancer treatment; and Lebanese scientist Huda Y. Zoghbi, for her work on neurological disorders including the genetic origins of Rett syndrome, a rare genetic neurological disorder that occurs primarily in girls. She was the 2017 winner of a $3 million Breakthrough Prize in Life Sciences -- founded by Sergey Brin, Priscilla Chan and Mark Zuckerberg.

"She's a very good example of someone who's likely to get Nobel recognition because of the awards she's been getting," Pendlebury said. "It's not just the accumulation of citations. Receiving these top prizes, which are chosen and selected by your peers, you get a stronger and stronger signal of how important this work has been."

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Why it's so hard to guess who's going to get a Nobel Prize - The Albany Herald

Hamad Bin Khalifa University (HBKU), a member of Qatar Foundation for Education, Science, and Community Development (QF), was founded in 2010 to continue fulfilling QFs vision of unlocking human potential. HBKU is a homegrown research and graduate studies University that acts as a catalyst for positive transformation in Qatar and the region while having a global impact.

About Qatar Biomedical Research Institute:

Qatar Biomedical Research Institute (QBRI), part of Hamad Bin Khalifa University (HBKU), is a national center of excellence in biomedical research. It aims to transform healthcare through harnessing and converting the latest advances in science, medicine and technology into novel discoveries that will lead to more effective treatments and preventive strategies for human diseases such as: diabetes, cancer and neurological disorders. The institute strives toward the development of novel diagnostic and therapeutic strategies to facilitate early diagnosis, treatment and management of these devastating diseases with the purpose of improving personalized medicine and healthcare. QBRI has recently occupied state-of-the-art life sciences laboratories in a newly established research campus.

Job Purpose:

To lead and develop a team of scientists and researchers leading to QBRI's growth and address developmental healthcare needs of Qatar. Conceive and establish competitive research programs including conducting translational research.

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Additional Requirements

How to apply

Please submit your completed application (CV, cover letter and the names of three references with their full contact information) via the following link: Click here to apply

Hamad Bin Khalifa University, being an equal opportunity educator and employer, is committed to maintaining culturally and academically diverse staff of the highest caliber.

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Principal Investigator job with HAMAD BIN KHALIFA UNIVERSITY | 227841 - Times Higher Education (THE)