StemCell Therapy

A Lesser-Known Chemotherapy Side Effect

The well-known side effects of chemotherapy can usually be dealt with fairly effectively for many women, though we empathize with anyone having to go through chemo. Two of the most common chemo side effects, nausea and hair loss, can both be managed with available treatments. The same is true of another, lesser-known side effect of chemotherapy, called neuropathy.

Neuropathy is the medical term for numbness or tingling in the fingers or toes, caused by powerful chemotherapy drugs damaging the peripheral nerves. Women receiving ovarian cancer chemotherapy with the taxane (Taxol) or platinum group of drugs are particularly susceptible to this side effect of treatment.

Fortunately oncologists are usually well-versed in this side effect, and take steps to try and minimize the problem during treatment. We usually assess for the degree of neuropathy prior to every dose of chemotherapy, says Dr. Manojkumar Bupathi, a medical oncologist at Rocky Mountain Cancer Center in Littleton, Colorado. In the event that neuropathy is getting worse, we can adjust the doses or delay treatments. We can also switch a patients drugs if it becomes an ongoing issue.

Symptoms

In addition to the numbness and tingling sensations that are characteristic of neuropathy, some patients may also experience:

Treatment

Patients can try several different approaches to dealing with neuropathy. We usually ask patients to use things like ice packs or protective gloves to try and mitigate the neuropathy, says Dr. Bupathi.

When simple treatments like this dont work, patients may want to consult a neurologist who can help treat the condition with a variety of different medications, including:

Prognosis

Most neuropathy goes away and improves over time, but sometimes it can take upwards of a year before it gets better, says Dr. Bupathi. While neuropathy may be permanent, Dr. Bupathi says that it usually persists as numbness or tingling, and isnt usually debilitating, where someone isnt able to walk or do basic things like buttoning a shirt or lifting a pen off a countertop.

If youre undergoing chemotherapy and start to experience symptomsnumbness, tingling, pain or weakness in the hands and feetmake sure to let your oncologist know so that you can take steps to relieve the symptoms and prevent permanent nerve damage.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Manojkumar Bupathi is a medical oncologist with Rocky Mountain Cancer Centers. Read More

Neuropathy is the medical term for numbness or tingling in the fingers or toes, caused by powerful chemotherapy drugs damaging the peripheral nerves. Women receiving ovarian cancer chemotherapy with the taxane (Taxol) or platinum group of drugs are particularly susceptible to this side effect of treatment.

Symptoms

In addition to the numbness and tingling sensations that are characteristic of neuropathy, some patients may also experience:

Treatment

Patients can try several different approaches to dealing with neuropathy. We usually ask patients to use things like ice packs or protective gloves to try and mitigate the neuropathy, says Dr. Bupathi.

When simple treatments like this dont work, patients may want to consult a neurologist who can help treat the condition with a variety of different medications, including:

Prognosis

Most neuropathy goes away and improves over time, but sometimes it can take upwards of a year before it gets better, says Dr. Bupathi. While neuropathy may be permanent, Dr. Bupathi says that it usually persists as numbness or tingling, and isnt usually debilitating, where someone isnt able to walk or do basic things like buttoning a shirt or lifting a pen off a countertop.

If youre undergoing chemotherapy and start to experience symptomsnumbness, tingling, pain or weakness in the hands and feetmake sure to let your oncologist know so that you can take steps to relieve the symptoms and prevent permanent nerve damage.

Learn more about SurvivorNet's rigorous medical review process.

Dr. Manojkumar Bupathi is a medical oncologist with Rocky Mountain Cancer Centers. Read More

Originally posted here:
How Do You Deal With The Painful Tingling of Neuropathy? A Side Effect of Chemotherapy for Ovarian Cancer - SurvivorNet

This report studies the Chemotherapy Induced Peripheral Neuropathy Treatment Market with many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers. Find the complete Chemotherapy Induced Peripheral Neuropathy Treatment Market analysis segmented by companies, region, type and applications in the report.

Market Segment by Companies: Aptinyx, Asahi Kasei Pharma, Regenacy Pharmaceuticals, MAKScientific, Metys Pharmaceuticals, Nemus Bioscience, PledPharma, Sova Pharmaceuticals, DermaXon, Immune Pharmaceuticals, Kineta, Krenitsky Pharmaceuticals, PeriphaGen, Apexian Pharma, WinSanTor, Solasia Pharma, and more

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Chemotherapy Induced Peripheral Neuropathy Treatment Market continues to evolve and expand in terms of the number of companies, products, and applications that illustrates the growth perspectives. The report also covers the list of Product range and Applications with SWOT analysis, CAGR value, further adding the essential business analytics. Chemotherapy Induced Peripheral Neuropathy Treatment Market research analysis identifies the latest trends and primary factors responsible for market growth enabling the Organizations to flourish with much exposure to the markets.

Market Segment by Regions, regional analysis covers:

Research Objectives:

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The Chemotherapy Induced Peripheral Neuropathy Treatment Market research report completely covers the vital statistics of the capacity, production, value, cost/profit, supply/demand import/export, further divided by company and country, and by application/type for best possible updated data representation in the figures, tables, pie chart, and graphs. These data representations provide predictive data regarding the future estimations for convincing market growth. The detailed and comprehensive knowledge about our publishers makes us out of the box in case of market analysis.

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Chemotherapy Induced Peripheral Neuropathy Treatment Industry Growth Analysis 2020-2026 with Market Share, Size, Trends, Revenue, CAGR and SWOT...

The report on the Chemotherapy Induced Peripheral Neuropathy Treatment market provides a birds eye view of the current proceeding within the Chemotherapy Induced Peripheral Neuropathy Treatment market. Further, the report also takes into account the impact of the novel COVID-19 pandemic on the Chemotherapy Induced Peripheral Neuropathy Treatment market and offers a clear assessment of the projected market fluctuations during the forecast period. The different factors that are likely to impact the overall dynamics of the Chemotherapy Induced Peripheral Neuropathy Treatment market over the forecast period (2019-2029) including the current trends, growth opportunities, restraining factors, and more are discussed in detail in the market study.

For top companies in United States, European Union and China, this report investigates and analyzes the production, value, price, market share and growth rate for the top manufacturers, key data from 2019 to 2025.

The Chemotherapy Induced Peripheral Neuropathy Treatment market report firstly introduced the basics: definitions, classifications, applications and market overview; product specifications; manufacturing processes; cost structures, raw materials and so on. Then it analyzed the worlds main region market conditions, including the product price, profit, capacity, production, supply, demand and market growth rate and forecast etc. In the end, the Chemotherapy Induced Peripheral Neuropathy Treatment market report introduced new project SWOT analysis, investment feasibility analysis, and investment return analysis.

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The major players profiled in this Chemotherapy Induced Peripheral Neuropathy Treatment market report include:

Segment by Type, the Chemotherapy Induced Peripheral Neuropathy Treatment market is segmented intoCalcium Channel 2-delta LigandsAntidepressantsOpioidsOthers

Segment by Application, the Chemotherapy Induced Peripheral Neuropathy Treatment market is segmented intoPlatinum AgentsTaxanesVinca AlkaloidsOthers

Regional and Country-level AnalysisThe Chemotherapy Induced Peripheral Neuropathy Treatment market is analysed and market size information is provided by regions (countries).The key regions covered in the Chemotherapy Induced Peripheral Neuropathy Treatment market report are North America, Europe, Asia Pacific, Latin America, Middle East and Africa. It also covers key regions (countries), viz, U.S., Canada, Germany, France, U.K., Italy, Russia, China, Japan, South Korea, India, Australia, Taiwan, Indonesia, Thailand, Malaysia, Philippines, Vietnam, Mexico, Brazil, Turkey, Saudi Arabia, UAE, etc.The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type, and by Application segment in terms of sales and revenue for the period 2015-2026.Competitive Landscape and Chemotherapy Induced Peripheral Neuropathy Treatment Market Share AnalysisChemotherapy Induced Peripheral Neuropathy Treatment market competitive landscape provides details and data information by players. The report offers comprehensive analysis and accurate statistics on revenue by the player for the period 2015-2020. It also offers detailed analysis supported by reliable statistics on revenue (global and regional level) by players for the period 2015-2020. Details included are company description, major business, company total revenue and the sales, revenue generated in Chemotherapy Induced Peripheral Neuropathy Treatment business, the date to enter into the Chemotherapy Induced Peripheral Neuropathy Treatment market, Chemotherapy Induced Peripheral Neuropathy Treatment product introduction, recent developments, etc.The major vendors covered:Aptinyx IncAsahi Kasei Pharma CorpRegenacy PharmaceuticalsMAKScientific LLCMetys Pharmaceuticals AGNemus Bioscience IncPledPharmaSova Pharmaceuticals IncDermaXon LLCKineta IncKrenitsky Pharmaceuticals IncPeriphaGenApexian PharmaWinSanTorSolasia Pharma K.K.

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Important Information that can be extracted from the Report:

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COVID-19 impact: Chemotherapy Induced Peripheral Neuropathy Treatment Market : In-depth Study on Industry Size and Analysis on Emerging Growth Factors...

Global Chemotherapy Induced Peripheral Neuropathy Treatment Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2026 aims to target the major concepts related to market growth, major types, and various end users applicable, regional analysis, productivity structure, current market situation. The market report is a proficient and deep analysis of the present situation and challenges. The report offers analysis with regards to the past and current market situation of the global Chemotherapy Induced Peripheral Neuropathy Treatment market. The report highlights all introducing income segmentation and also a firm sketch of the top players. It comprises streamlined financial data obtained from various research sources. The report analyzes the market players, sub-segments and sections, product category, and major improvements in the market.

Overview of The Report:

Top players are examined for revenue areas manufacturing, market rivalry, capacity, sales (value), moderate price, fabricating base supply and market share, and product types. The report also computes the limits and strong points of the players. The report studies key opportunities in the market and segmentation of market size, by volume and value, on the basis of application type and geography. The report focuses on innovative trends, implementing reasonable pricing stats in the competitive market. The overall description of the global Chemotherapy Induced Peripheral Neuropathy Treatment market will assist our viewers to comprehend the market in the best way. It sheds light on the industry parameters by accessing the market growth, consumption volume, the upcoming market trends, and the different prices variation for the forecast year from 2020 to 2026.

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The report covers a number of the players in the market, including: Aptinyx, Asahi Kasei Pharma, Regenacy Pharmaceuticals, MAKScientific, Metys Pharmaceuticals, Nemus Bioscience, PledPharma, Sova Pharmaceuticals, DermaXon, Immune Pharmaceuticals, Kineta, Krenitsky Pharmaceuticals, PeriphaGen, Apexian Pharma, WinSanTor, Solasia Pharma,

Segmentation by product type and analysis of the market: Calcium Channel _2-delta Ligands, Antidepressants, Opioids, Others

Segmentation by application and analysis of the market: Platinum Agents, Taxanes, Vinca Alkaloids, Others

The scope of the report covers market eventualities to a comparative rating between major players, price, and profit of the required market regions. This report covers North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa). It focuses on the foremost and the progressing countries from every region in detail.

The report represents the ongoing marketing trends that are faced by the market competitors, the ups, and downs in the global Chemotherapy Induced Peripheral Neuropathy Treatment market. Subsequently, it discovers the worlds main Chemotherapy Induced Peripheral Neuropathy Treatment industry market requirements, for example, demand, distribution, profit, production, capacity, and promote growth speed and prediction, etc. The company further divides even the economy, by state also from application/type for its landscape analysis.

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Global Chemotherapy Induced Peripheral Neuropathy Treatment Market 2020 Company Profiles, Key Strategic Moves and Developments, Operating Business...

New York City, United States The change during the COVID-19 pandemic has overhauled our dependence on pattern setting developments, for instance, expanded reality, computer generated reality, and the Healthcare web of things. The unfulfilled cash related targets are persuading the relationship to grasp robotization and forefront advancements to stay ahead in the market competition. Associations are utilizing this open entryway by recognizing step by step operational needs and showing robotization in it to make an automated structure as far as might be feasible

Ischemic optic neuropathy is caused due to a small vessel infraction of the optic nerve and is a major cause of blindness or impaired vision among the inflicted. There are two types of ischemic optic neuropathies viz. anterior ischemic optic neuropathy and posterior or non-anterior ischemic optic neuropathy. Anterior ischemic optic neuropathy is caused by the inflammation of arteries supplying blood to the optic nerve whereas posterior or non-anterior ischemic optic neuropathy is caused due to reasons other than inflammation of the arteries. Anterior ischemic optic neuropathy is more prevalent as compared to posterior ischemic optic neuropathy. In anterior ischemic optic neuropathy, immediate treatment is required to prevent vision loss in the fellow eye as approximately 50 percent of cases have chances of blindness in another eye within a span of 5 to 10 days without treatment. The symptoms of ischemic optic neuropathy include unilateral, acute and painless visual loss for hours to days. Hypertension, diabetes, and hypercholesterolemia are some of the well-known risk factors associated with ischemic optic neuropathy disease. Other factors include generalized hypoperfusion, sleep apnea, nocturnal hypotension, vasospasm, severe anemia and failure of autoregulation.

Technological advancements in ischemic optic neuropathy treatment and availability of alternative drugs are anticipated boost the demand for ischemic optic neuropathy treatments over the forecast period.

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The global ischemic optic neuropathy treatment market can be segmented on the basis of disease type, treatment type and end user.

On the basis of disease type, the global ischemic optic neuropathy treatment market can be segmented into:

On the basis of treatment type, the global ischemic optic neuropathy treatment market can be segmented into:

On the basis of end user, the global ischemic optic neuropathy treatment market can be segmented into:

The global ischemic optic neuropathy treatment market is expected to register a significant CAGR over the forecast period. The increasing adoption of recently approved intravitreal implants in the treatment of ophthalmology diseases is anticipated to propel the growth of the ischemic optic neuropathy treatment market over the forecast period. Leading pharmaceutical and drug manufacturing companies from developed countries are substantially investing in R&D, infrastructure and new technologies in ophthalmology therapeutics to capture a market share in the growing burden of eye diseases, which also boosts the growth of the global ischemic optic neuropathy treatment market. With growing awareness towards eye-related complications that lead to blindness, geriatric population and diabetic patients in developed countries, such as the U.S., Russia, and Poland, Germany and Japan are seen to have a proactive approach for treatment related to complications rather than reactive treatment, which also bolsters the growth of the market of ischemic optic neuropathy treatment.

Corticosteroid is the first choice of therapy for patients with ischemic optic neuropathy in prominent countries, such as the U.S., Germany, France, and Russia; however, a majority of patients have developed resistance to anti-VEGF, which leads to the adoption of alternative therapy in patients with ischemic optic neuropathy. This is anticipated to drive the growth of the global ischemic optic neuropathy treatment market in the long run.

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However, medications such as intravitreal injections of anti-VEGF drugs and corticosteroids lead to an instant increase in intraocular pressure, which may lead to severe adverse effects such as conjunctival haemorrhage, eye pain, cataract, vitreous floaters, intraocular pressure increased and vitreous detachment. This may restrain the growth of the global ischemic optic neuropathy treatment market.

Regional analysis includes

North America is a dominant region in the market and contributes a leading share to the global ischemic optic neuropathy treatment market in terms of revenue. The market in the region is expected to register significant growth over the forecast period due to the availability of developed medical infrastructure and treatment facilities in the region. Europe also contributes a moderate share and registered a healthy growth rate in the global ischemic optic neuropathy treatment market. The APEJ region has become a lucrative market for ischemic optic neuropathy treatment and is anticipated to register a significant share over the forecast period, due to the increase in research and development activities along with the growth in medical tourism in the region. Latin America and MEA are in the nascent stage in the global ischemic optic neuropathy treatment market and are expected to register moderate growth over the forecast period.

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Some of the market players operating in the ischemic optic neuropathy treatment market include ,

The report covers exhaustive analysis on:

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Ischemic Optic Neuropathy Treatment Market Upcoming Trends, Incredible Possibilities, Business Opportunities ,Regional Outlook and Forecast 2018-2026...

Fact.MR has adopted multi-disciplinary approach to shed light on the evolution of the global Diabetic Neuropathy market during the historical period of 2014 2019. The study presents a deep-dive assessment of the current growth dynamics, major avenues in the estimation year of 2020, and key prospects over the forecast period 2020 2025.The Diabetic Neuropathy market study includes a thorough analysis of the overall competitive landscape and the company profiles of leading market players involved in the global Diabetic Neuropathy market. Further, the presented study offers accurate insights pertaining to the different segments of the global Diabetic Neuropathy market such as the market share, value, revenue, and how each segment is expected to fair post the COVID-19 pandemic.

The global diabetic neuropathy is anticipated to surge at a CAGR of 5.6% during the forecast period (2020-2025). Extensive rounds of primary and a comprehensive secondary research have been leveraged by the analysts at Fact.MR to arrive at various estimations and projections of the Diabetic Neuropathy market, both at global and regional levels. The analysts have used numerous industry-wide prominent business intelligence tools to consolidate facts, figures, and market data into revenue estimations and projections in theDiabetic Neuropathy market.

After reading the Diabetic Neuropathy market report, readers get insight into:

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The Diabetic Neuropathy market report offers assessment of prevailing opportunities in various regions and evaluates their shares of revenue by the end of different years of the assessment period. Key regions covered comprise:

The evaluation of the competitive landscape in the Diabetic Neuropathy market covers the profile of the following top players:

Johnson & Johnson (Janssen Global Services, LLC), Boehringer Ingelheim GmbH, NeuroMetrix, Inc., Eli Lilly and Company, GlaxoSmithKline Plc.,Lupin Limited, Astellas Pharma Inc., Pfizer, Inc., Glenmark Pharmaceuticals Ltd., Arbor Pharmaceuticals, LLC and Depomed, Inc.

To expand the understanding of opportunities in the global Diabetic Neuropathy market report looks at close quarters into the opportunities and new avenues in following key segments:

In addition to understanding the demand patterns of various Distribution Channel, the report on the Diabetic Neuropathy market also enumerates trends expected to attract investments by other various associated industries.

On the basis of Disorder types, the Diabetic Neuropathy market report offers insight into major adoption trends for the following segments:

By Treatment Type,

Peripheral Neuropathy

Drugs:

Analgesic:

Topical:

Opioid:

NSAIDs:

Antidepressants:

TCAs:

SNRIs:

SSRIs:

Anticonvulsant Drugs:

Other Drugs

Radiotherapy:

Physiotherapy

The global Diabetic Neuropathy market report offers detailed assessments and quantitative evaluations that shed light on numerous key aspects that have shaped its evolution over the historical period. In coming years, some of the key aspects that will shape the growth prospects during the forecast period are objectively covered in the study.

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Some important questions that the Diabetic Neuropathy market report tries to answer exhaustively are:

About Fact.MR

Fact.MR is a fast-growing market research firm that offers the most comprehensive suite of syndicated and customized market research reports. We believe transformative intelligence can educate and inspire businesses to make smarter decisions. We know the limitations of the one-size-fits-all approach; thats why we publish multi-industry global, regional, and country-specific research reports.

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Diabetic Neuropathy Market Demand Surges Owing to Increasing Production Associated With Covid-19, Concludes Fact.MR - The Cloud Tribune

Shuhei Nakanishi,1 Hidenori Hirukawa,1 Masashi Shimoda,1 Fuminori Tatsumi,1 Kenji Kohara,1 Atsushi Obata,1 Seizo Okauchi,1 Junpei Sanada,1 Yoshiro Fushimi,1 Akiko Mashiko,1 Tomoatsu Mune,1 Kohei Kaku,2 Hideaki Kaneto1

1Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Okayama, Japan; 2Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan

Correspondence: Shuhei Nakanishi Email n-shuhei@umin.net

Introduction: This study aimed to examine the association between severity of diabetic neuropathy and weight loss during hospitalization in overweight participants with type 2 diabetes.Patients and Methods: Participants of this study comprised 193 patients who were hospitalized for type 2 diabetes treatment. The participants were divided into two groups in the study, based on whether or not reduction of bodyweight was at least 3% during hospitalization. Using Cox models, the association between severity of neuropathy and effectiveness of weight loss under a controlled diet was analyzed. Autonomic neuropathy was assessed on patient admission by R-R interval, as measured in an electrocardiogram (CVRR), and sensory neuropathy was assessed using both 128-Hz tuning-fork vibration and Achilles tendon reflex (ATR).Results: The adjusted hazard ratio for weight loss of at least 3% for CVRR was 1.17 (95% confidence interval 1.07 1.28, P=0.0006) and for vibration time 1.93 (1.01 3.68, P=0.045). After dividing CVRR and vibration time into tertiles based on participant number, the adjusted hazard ratio for the high tertile of CVRR was 2.17 (1.29 3.62, P=0.003), and for the long tertile of vibration time 1.84 (1.10 3.08, P=0.02), compared with the low and short tertiles, respectively. No association was detected between ATR category and weight loss.Conclusion: Severity of diabetic neuropathy was found to be a determinant in weight loss under a caloric restriction regimen for patients with type 2 diabetes. The results of the study suggest that the peripheral nervous system is involved in responses to medical intervention for treatment for type 2 diabetes including bodyweight management.

Keywords: diabetic neuropathy, weight loss, R-R interval as measured in an electrocardiogram, type 2 diabetes

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Association Between Severity of Diabetic Neuropathy and Success in Wei | DMSO - Dove Medical Press

Krenitsky Pharmaceuticals Inc

Moreover, the Chemotherapy Induced Peripheral Neuropathy Treatment report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Chemotherapy Induced Peripheral Neuropathy Treatment market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Chemotherapy Induced Peripheral Neuropathy Treatment market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Chemotherapy Induced Peripheral Neuropathy Treatment Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Chemotherapy Induced Peripheral Neuropathy Treatment Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Chemotherapy Induced Peripheral Neuropathy Treatment Market, By Deployment Model

5.1 Overview

6 Chemotherapy Induced Peripheral Neuropathy Treatment Market, By Solution

6.1 Overview

7 Chemotherapy Induced Peripheral Neuropathy Treatment Market, By Vertical

7.1 Overview

8 Chemotherapy Induced Peripheral Neuropathy Treatment Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Chemotherapy Induced Peripheral Neuropathy Treatment Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Chemotherapy Induced Peripheral Neuropathy Treatment Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Cole of Duty

Arbor Pharmaceuticals

Moreover, the Neuropathy Pain Treatment report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Neuropathy Pain Treatment market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Neuropathy Pain Treatment market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Neuropathy Pain Treatment Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Neuropathy Pain Treatment Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Neuropathy Pain Treatment Market, By Deployment Model

5.1 Overview

6 Neuropathy Pain Treatment Market, By Solution

6.1 Overview

7 Neuropathy Pain Treatment Market, By Vertical

7.1 Overview

8 Neuropathy Pain Treatment Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Neuropathy Pain Treatment Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Ever seen an advertisement for something called diabetic socks, and wondered what in the world that was about? Can socks get diabetes? Can other items of clothing be diabetic? What does diabetes have to do with feet anyway?

Footcare certainly isn't the first thing that comes to mind when one thinks about diabetes, but the fact is that diabetics are at a high risk of foot injuries and infections due to the potential damage high blood sugar levels can do to the nervous and circulatory systems.

A variety of other factors can also pose a risk to diabetics and their feet.

Feet must be washed and thoroughly dried regularly to prevent fungal infections like athletes' feet from excess moisture. Washing your feet with warm, soapy water each day will help prevent bacteria buildup and infection. Applying talcum powder between toes afterward can dry out those areas and reduce the chance of athletes foot and other fungal infections.

Extreme temperatures are also a hazard. As tempting as it may be, dont put your feet up in front of your campfire. You should also wear closed shoes when walking on hot sand or pavement and always apply sunscreen to your feet when theyre exposed to the sun. If you have nerve damage in your feet, you may not notice a burn until its severe, so its best to prevent it altogether.

Cold feet can also be related to restricted blood flow, so keep them warm by sleeping with socks on in the winter and wearing warm, waterproof shoes in bad weather.

While diligent daily care is the best way to keep feet healthy, diabetic socks are a great tool to help you out.

Diabetic socks, are socks specially designed to prevent the development of foot problems among those living with diabetes. Their features are engineered to address all the aforementioned issues to help you keep your feet healthy.

These socks are usually made of a material that wicks away moisture, like that found in exercise clothing, so that the feet stay dry. Some brands even have antimicrobial features in their fabric to help prevent bacteria and fungal growth. In colder temperatures, these socks will keep your feet warm, ensuring good circulation.

These socks are also seamless, so you dont have to worry about pesky rubbing producing blisters. In someone with neuropathy or chronic high blood sugar, something as small as a blister can ultimately turn into an ulcer. Special padding in sensitive areas also helps to prevent injuries like this.

In many cases, diabetic socks have white soles. This can alert the wearer if they have any sort of foot wound because the drainage of blood or other fluid will be visible from outside the sock.

There are a variety of diabetic socks available, with different features and advantages to suit each individuals needs. Consider which are best for you or get a variety for different times of the year and different activity levels.

In general, diabetic socks serve one or more of three purposes: they keep your feet dry, they keep temperature steady, and they prevent abrasions. All will do each of these to some degree, but you can choose which to prioritize in your choices.

While most diabetic socks have some sort of moisture-wicking technology, be sure to look for this specifically if you are very active or have a physically demanding job. These materials pull moisture away from the feet to help to evaporate the sweat, reducing the risk of fungus and infections. They also help to cut down on odor.

Copper-infused socks are made with copper-infused yarn and also have antifungal properties and anti-odor protection.

Padded acrylic socks are ideal for those who exercise often because they keep feet dry and help cushion them to reduce the risk of any foot injury.

You can also find heavily padded or gel-padded socks if you are in need of this additional cushioning.

The yarns that make up your socks can also make a huge difference in the health of your feet. While most diabetic socks are made from soft yarns like wool and bamboo, you can also find those specially made to reduce friction that causes blisters.

If youre really looking to maximize the benefits of your socks, consider new smart socks, which have embedded sensors that alert you of foot temperature changes that might be signs of friction that causes blisters to form. These socks need to be replaced regularly but are a great option for those without much feeling in their feet.

Whatever type of sock you choose, be sure to change and wash them regularly and replace them at the first sign of wear and tear, as holes or pilling can themselves cause injury.

Its important to remember that while diabetic socks are a great tool for the prevention of foot problems, you should always see your doctor if youve already developed an issue.

Slow-healing wounds, unusual odor, and continuous pain in legs are all signs that something is wrong and you should check in with your doctor. Also, keep an eye out for changes in the color or shape of your feet, and ask your doctor to do a foot check-up at your next visit to make sure theyre healthy. Diligent care is the best way to prevent foot problems from developing.

Read the original:
What are Diabetic Socks and Why Might You Need Them? - The Jerusalem Post

GlobalChemotherapy Induced Peripheral Neuropathy TreatmentMarket Report 2020, Forecast to 2025presents a historical overview of market size, revenue, share, forecast, and market drivers. The report features detailed insights and deep research on the globalChemotherapy Induced Peripheral Neuropathy Treatmentmarket. The report studies various segments, as well as key opportunities in the market and influencing factors which will help businesses increase their footprints in the industry. A comprehensive analysis of the product scope and market risks has been given for the participants. The report shows the company profile of the major vendors along with their winning strategies to give business owners, stakeholders, and field marketing personal a competitive edge over others operating in the market.

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The Market Report Addresses:

The report provides historical and forecasts market data including demand, application details, price trends, and company shares of the leading manufacturers by geography, and estimation of the globalChemotherapy Induced Peripheral Neuropathy Treatmentmarket size by volume and value. The growth estimation of the market is offered on the basis of calculation by various segmentation and past and current data. This market has been divided into types, applications, and regions. The report also covers the growth aspects of the market along with the restraining factors which are expected to impact the overall growth of the market in the estimated forecast period from 2020 to 2025.

The top manufacturers/suppliers which are currently operating in the globalChemotherapy Induced Peripheral Neuropathy Treatmentmarket industry includes:Aptinyx, Asahi Kasei Pharma, Regenacy Pharmaceuticals, MAKScientific, Metys Pharmaceuticals, Nemus Bioscience, PledPharma, Sova Pharmaceuticals, DermaXon, Immune Pharmaceuticals, Kineta, Krenitsky Pharmaceuticals, PeriphaGen, Apexian Pharma

Market Regions and Countries Level Analysis:

Regional analysis is a highly comprehensive section of this report. This segmentation sheds light on the sales of theChemotherapy Induced Peripheral Neuropathy Treatmenton regional- and country-level. This data provides a detailed and accurate country-wise volume analysis and region-wise market size analysis of the global market. Market segmented by region/country:North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

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Moreover, the report aims to deliver evaluation and essential information on the competitive landscape to meet the unique requirements of the companies and individuals operating in the market. The study recognizes the factors affecting the globalChemotherapy Induced Peripheral Neuropathy Treatmentmarket growth such as drivers, restraints, opportunities, and trends. The report also recognizes emerging players with a potentially strong product portfolio and creates effective counter-strategies to gain competitive advantage. The report features reliable high-quality data and analysis which is suitable for supporting your internal and external presentations. The market research report will also help create regional and country strategies on the basis of local data and analysis.

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Magnifier Research is a leading market intelligence company that sells reports of top publishers in the technology industry. Our extensive research reports cover detailed market assessments that include major technological improvements in the industry. Magnifier Research also specializes in analyzing hi-tech systems and current processing systems in its expertise. We have a team of experts that compile precise research reports and actively advise top companies to improve their existing processes. Our experts have extensive experience in the topics that they cover. Magnifier Research provides you the full spectrum of services related to market research, and corroborate with the clients to increase the revenue stream, and address process gaps.

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Global Chemotherapy Induced Peripheral Neuropathy Treatment Market 2020 with COVID-19 After Effects Analysis by Emerging Trends, Industry Demand,...

The research report on the Diabetic Peripheral Neuropathy Treatment Market offers a comprehensive study on market share, size, growth aspects, and major players. In addition, the report contains brief information about the regional competitive landscape, market trends, and drivers, opportunities and challenges, distributors, sales channels, risks & entry barriers, as well as Porters Five Forces Analysis. Moreover, the main objective of this report is to offer a detailed analysis of how the market aspects potentially influence the coming future of the Diabetic Peripheral Neuropathy Treatment market. The report also offers a comprehensive analysis about the competitive manufacturers as well as the new entrants also studies along with their brief research.

The report includes the latest coverage of the impact of COVID-19 on the Diabetic Peripheral Neuropathy Treatment industry. The incidence has affected nearly every aspect of the business domain. This study evaluates the current scenario and predicts future outcomes of the pandemic on the global economy.

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In addition, this report also contains a price, revenue, market share, and production of the service providers is also mentioned with accurate data. Moreover, the global Diabetic Peripheral Neuropathy Treatment report majorly focuses on the current developments, new possibilities, advancements, as well as dormant traps. Furthermore, the Diabetic Peripheral Neuropathy Treatment market report offers a complete analysis of the current situation and the advancement possibilities of the Diabetic Peripheral Neuropathy Treatment market across the globe. This report analyses substantial key components such as production, capacity, revenue, price, gross margin, sales revenue, sales volume, growth rate, consumption, import, export, technological developments, supply, and future growth strategies.

We provide a detailed analysis of key players operating in the Diabetic Peripheral Neuropathy Treatment Market:

Moreover, the Diabetic Peripheral Neuropathy Treatment report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Diabetic Peripheral Neuropathy Treatment market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Diabetic Peripheral Neuropathy Treatment market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Diabetic Peripheral Neuropathy Treatment Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Diabetic Peripheral Neuropathy Treatment Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Diabetic Peripheral Neuropathy Treatment Market, By Deployment Model

5.1 Overview

6 Diabetic Peripheral Neuropathy Treatment Market, By Solution

6.1 Overview

7 Diabetic Peripheral Neuropathy Treatment Market, By Vertical

7.1 Overview

8 Diabetic Peripheral Neuropathy Treatment Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Diabetic Peripheral Neuropathy Treatment Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Diabetic Peripheral Neuropathy Treatment Market Growth by Top Companies, Trends by Types and Application, Forecast to 2026 - Cole of Duty

Astellas Pharma

Moreover, the Diabetic Neuropathy Drugs report offers a detailed analysis of the competitive landscape in terms of regions and the major service providers are also highlighted along with attributes of the market overview, business strategies, financials, developments pertaining as well as the product portfolio of the Diabetic Neuropathy Drugs market. Likewise, this report comprises significant data about market segmentation on the basis of type, application, and regional landscape. The Diabetic Neuropathy Drugs market report also provides a brief analysis of the market opportunities and challenges faced by the leading service provides. This report is specially designed to know accurate market insights and market status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Table of Content

1 Introduction of Diabetic Neuropathy Drugs Market

1.1 Overview of the Market1.2 Scope of Report1.3 Assumptions

2 Executive Summary

3 Research Methodology

3.1 Data Mining3.2 Validation3.3 Primary Interviews3.4 List of Data Sources

4 Diabetic Neuropathy Drugs Market Outlook

4.1 Overview4.2 Market Dynamics4.2.1 Drivers4.2.2 Restraints4.2.3 Opportunities4.3 Porters Five Force Model4.4 Value Chain Analysis

5 Diabetic Neuropathy Drugs Market, By Deployment Model

5.1 Overview

6 Diabetic Neuropathy Drugs Market, By Solution

6.1 Overview

7 Diabetic Neuropathy Drugs Market, By Vertical

7.1 Overview

8 Diabetic Neuropathy Drugs Market, By Geography

8.1 Overview8.2 North America8.2.1 U.S.8.2.2 Canada8.2.3 Mexico8.3 Europe8.3.1 Germany8.3.2 U.K.8.3.3 France8.3.4 Rest of Europe8.4 Asia Pacific8.4.1 China8.4.2 Japan8.4.3 India8.4.4 Rest of Asia Pacific8.5 Rest of the World8.5.1 Latin America8.5.2 Middle East

9 Diabetic Neuropathy Drugs Market Competitive Landscape

9.1 Overview9.2 Company Market Ranking9.3 Key Development Strategies

10 Company Profiles

10.1.1 Overview10.1.2 Financial Performance10.1.3 Product Outlook10.1.4 Key Developments

11 Appendix

11.1 Related Research

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Peripheral neuropathy is a common complication of primary Sjgren syndrome and may be associated with a diminished health-related quality of life (HR-QoL), according to research results published in Rheumatology International.

Researchers sought to compare HR-QoL outcomes in patients with primary Sjgren syndrome, both with and without peripheral neuropathy. They also aimed to examine the associations between the neurologic complications and components of HR-QoL outcomes using the 36-item Short Form Health Survey (SF-36). Overall, 50 adult patients with primary Sjgren syndrome (median age, 57.5 years; 96% women) were included in the study.

Of the total cohort, 80% (n=40) reported subjective symptoms, including paresthesia or other symptoms that were suggestive of neuropathic pain on a periodic or permanently present basis. In total, 46% (n=23) of patients met the criteria for a diagnosis of peripheral neuropathy (PNS+); the remaining patients were referred to as PNS-.

Researchers indicated the most common peripheral nervous system manifestation to be sensorimotor neuropathy, which was present in 47% of patients who were PNS+. Mononeuropathy was present in 26%, pure axonal sensory neuropathy, axonal motor neuropathy, and small fiber neuropathy were each present in 4.3%, and cranial nerve involvement was present in 17.4% of patients who were PNS+; 1 patient experienced both cranial and sensorimotor neuropathy. Among 35% of patients who were PNS+, neurologic symptoms preceded patients diagnosis of primary Sjgren syndrome.

Investigators studied data from both groups of patients in terms of clinical characteristics and laboratory testing results, and observed similarity in age, disease duration, time from diagnosis, and time of symptom onset. Clinical manifestations, including parotid enlargement, respiratory tract involvement, lymphadenopathy, and hypocomplementemia were significantly more prevalent among patients who were PNS+ vs those who were PNS- (74% vs 44%; 65% vs 37%; 61% vs 19%; and 26% vs 7%, respectively). In addition, patients in the PNS+ vs PNS- group were statistically significantly more likely to frequently use cyclophosphamide because of extraglandular manifestations (17% vs 0%, respectively).

Both groups were also compared based on the results of the visual analog scale (VAS)-pain scale, SF-36, and an interview regarding pain type. Among patients who were PNS+ vs PNS-, median VAS-pain was 3 vs 0, respectively (range, 0-7; P =.229). Neuropathic type pain was often observed across both subgroups but was predominantly among patients who were PNS+ compared with those who were PNS- (70% vs 41%).

Across the 5 domains of the SF-36, patients who were PNS+ vs PNS- had significantly lower results in terms of physical and emotional roles, vitality, bodily pain, and general health (P .05).

Study limitations included potential referral bias in patient selection, researchers inability to conduct neurophysiologic testing in individuals suspected of pure small-fiber neuropathy, and a lack of unambiguous differentiation between Sjgren syndrome-related neuropathy and other forms of neuropathy.

Our study showed that peripheral nervous involvement is frequent in [patients with primary Sjgren syndrome] and it is correlated with worse HR-QoL, the researchers concluded. To get the complete picture of [patients with Sjgren syndrome], a holistic approach starting with a comprehensive assessment of disease activityis needed.

Reference

Jasklska M, Chylinska M, Masiak A, et al. Peripheral neuropathy and health-related quality of life in patients with primary Sjgrens syndrome: A preliminary report [published online March 14, 2020]. Rheumatol Int. doi:10.1007/s00296-020-04543-2

This article originally appeared on Rheumatology Advisor

Originally posted here:
Peripheral Neuropathy Is Common, Associated With Diminished Health-Related Quality of Life in Sjgren Syndrome - Neurology Advisor

Patients with trigeminal nerve damage report moderate-to-severe levels of pain and unpleasantness with evidence for varied site-dependent somatosensory disturbances. This is based on the results of a comprehensive set of psychophysical and electrophysiological investigations published in The Clinical Journal of Pain.

The goal of the current study was to investigate the somatosensory changes related to trigeminal nerve damage using psychophysical and electrophysiological tools.

The study cohort included 37 patients (24 women, mean age 44.6 years) attending Department of Dentistry and Oral Health, Aarhus University, Denmark and Faculty of Odontology, Malm University, Sweden; and Skne University Hospital, Lund, Sweden. Most patients were diagnosed with painful posttraumatic trigeminal neuropathy (n=30), and a minority had nonpainful posttraumatic trigeminal neuropathy (n=7).

Psychophysical tests like quantitative sensory testing and qualitative sensory testing and the electrophysiological nociceptive-specific blink reflex were performed.

The scores from the Pain Catastrophizing Scale (PCS), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory (STAI) measuring state anxiety (STAI-S) and STAI-T measuring trait anxiety, the 8-item Jaw Function Limitation Scale (JFLS-8), 4-item and 15-item Patient Health Questionnaire (PHQ-4 and PHQ-15), Oral Behaviors Checklist (OBC), and 49-item Oral Health Impact Profile (OHIP-49) were compared between the patients and a group of 20 healthy controls (10 women and 10 men, mean age 37.7 11.4 years).

The main quantitative sensory testing finding observed was an abnormal somatosensory function in 1 parameter in 94.7% of patients with damage to the nerve branches innervating the extraoral region and 88.9% of patients with damage to the nerve branches innervating the intraoral region.

Among 19 patients in whom extraoral QST was performed, at least 1 parameter with loss or gain of somatosensory function was evident in 13 patients (68.4%) on the unaffected side and in 18 patients (94.7%) on the affected side. Among 18 intraorally assessed subjects, in 15 patients (83.3%) there was at least 1 parameter with loss or gain of somatosensory function on the unaffected side and in 16 patients (88.9%) on the affected side.

Qualitative sensory testing identified a side-to-side difference in the tactile and pinprick stimulation in >77% of the patients. An abnormal nociceptive-specific blink reflex response was dependent on the trigeminal branch stimulated; abnormal findings were observed in > 71% of patients for V2 branch and > 42% for the V3 branch stimulation. No correlations were seen between any of the QST and nociceptive-specific blink reflex parameters.

Compared to the healthy participants, patients showed higher scores for pain catastrophizing (10.79.4 vs 17.413.0, P <.001), symptoms of depression (3.23.0 vs 10.29.1, P =.029) and anxiety (STAI-S: 30.17.1 vs 37.913.5; STAI-T: 33.56.2 vs 39.912.7, P =.038), limited jaw function (0.10.5 vs 15.515.5, P <.001), more somatic symptoms, and significantly impaired oral health-related quality of life.

The researchers acknowledged several study limitations, including difficult and low recruitment with potential variation in data collection, use of healthy reference data instead of age- and sex-matched controls, and lack of testing extra-trigeminal sites owing to concern for patient fatigue from multiple investigations.

The present study comprehensively quantifies and profiles the pathophysiological characteristics of trigeminal nerve damage and attests to the need of using clinical history, psychophysical, and electrophysiological investigations for diagnosis of trigeminal nerve damage, concluded the researchers.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors disclosures.

Reference

Pillai RS, Pigg M, List T, et al. Assessment of somatosensory and psychosocial function of patients with trigeminal nerve damage. Clin J Pain. 2020;36(5):321335. doi:10.1097/AJP.0000000000000806

More here:
Somatosensory and Psychosocial Changes Related to Trigeminal Nerve Damage - Neurology Advisor

Persistence Market Research recently published a market study that sheds light on the growth prospects of the global Chemotherapy Induced Peripheral Neuropathy market during the forecast period (20XX-20XX). In addition, the report also includes a detailed analysis of the impact of the novel COVID-19 pandemic on the future prospects of the Chemotherapy Induced Peripheral Neuropathy market. The report provides a thorough evaluation of the latest trends, market drivers, opportunities, and challenges within the global Chemotherapy Induced Peripheral Neuropathy market to assist our clients arrive at beneficial business decisions.

The recent published research report sheds light on critical aspects of the global Chemotherapy Induced Peripheral Neuropathy market such as vendor landscape, competitive strategies, market drivers and challenges along with the regional analysis. The report helps the readers to draw a suitable conclusion and clearly understand the current and future scenario and trends of global Chemotherapy Induced Peripheral Neuropathy market. The research study comes out as a compilation of useful guidelines for players to understand and define their strategies more efficiently in order to keep themselves ahead of their competitors. The report profiles leading companies of the global Chemotherapy Induced Peripheral Neuropathy market along with the emerging new ventures who are creating an impact on the global market with their latest innovations and technologies.

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The recent published study includes information on key segmentation of the global Chemotherapy Induced Peripheral Neuropathy market on the basis of type/product, application and geography (country/region). Each of the segments included in the report is studies in relations to different factors such as market size, market share, value, growth rate and other quantitate information.

The competitive analysis included in the global Chemotherapy Induced Peripheral Neuropathy market study allows their readers to understand the difference between players and how they are operating amounts themselves on global scale. The research study gives a deep insight on the current and future trends of the market along with the opportunities for the new players who are in process of entering global Chemotherapy Induced Peripheral Neuropathy market. Market dynamic analysis such as market drivers, market restraints are explained thoroughly in the most detailed and easiest possible manner. The companies can also find several recommendations improve their business on the global scale.

The readers of the Chemotherapy Induced Peripheral Neuropathy Market report can also extract several key insights such as market size of varies products and application along with their market share and growth rate. The report also includes information for next five years as forested data and past five years as historical data and the market share of the several key information.

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Global Chemotherapy Induced Peripheral Neuropathy Market by Companies:

The company profile section of the report offers great insights such as market revenue and market share of global Chemotherapy Induced Peripheral Neuropathy market. Key companies listed in the report are:

key players and product offerings

Global Chemotherapy Induced Peripheral Neuropathy Market by Geography:

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Some of the Major Highlights of TOC covers in Chemotherapy Induced Peripheral Neuropathy Market Report:

Chapter 1: Methodology & Scope of Chemotherapy Induced Peripheral Neuropathy Market

Chapter 2: Executive Summary of Chemotherapy Induced Peripheral Neuropathy Market

Chapter 3: Chemotherapy Induced Peripheral Neuropathy Industry Insights

Chapter 4: Chemotherapy Induced Peripheral Neuropathy Market, By Region

Chapter 5: Company Profile

And Continue

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Assessing the Fallout From the Coronavirus Pandemic Chemotherapy Induced Peripheral Neuropathy Market Comprehensive Survey 2019 2029 - Jewish Life...

Dose-limiting toxicities (DLTs) were minimal with the combination of canakinumab plus pembrolizumab (Keytruda), and platinum-based doublet chemotherapy in patients with advanced or metastatic nonsmall cell lung cancer who were treated in the phase II CANOPY-1 study (NCT03631199), demonstrating that the combination could be well-tolerated in these patients.1

Results from the safety run-in portion of the study were presented at the 2020 American Association for Cancer Research (AACR) Virtual Annual Meeting. The purpose for part 1 of the CANOPY-1 study was to determine a safe dose of canakinumab for the second portion of the study.

Overall, 30 patients with previously untreated stage IIIB or IIIC or stage IV NSCLC were enrolled to the safety run-in portion of CANOPY-1. For induction therapy, patients in cohort A (n = 10) received canakinumab in combination with pembrolizumab, carboplatin and pemetrexed; cohort B (n = 11) received canakinumab plus pembrolizumab, cisplatin, and pemetrexed; and cohort C (n = 9) received canakinumab plus pembrolizumab, carboplatin, and paclitaxel. All cohorts received maintenance treatment of canakinumab, pembrolizumab, and pemetrexed.

The median age of patients was 63 years (range, 28-77), and the majority of patients were men (73.3%). Patients had an ECOG performance status of 0 (30.0%) or 1 (70.0%) and were either white (60.0%) or Asian (40.0%). Most patients were former smokers (63.3%) while some were never smokers (23.3%) and current smokers (13.3%).

Treatment was discontinued in 6 of the 30 patients (20.0%) and remained ongoing in the remaining 24 patients (80.0%). The reason for treatment discontinuation was progressive disease in 5 patients and death in 1 patient.

No serious adverse events (AEs) were fatal or considered related to canakinumab. AEs led to discontinuation of 1 of the study drugs in 3 patients (10%), all of which were included in cohort C. Hepatitis led to discontinuation of pembrolizumab, and both polyneuropathy and peripheral neuropathy led to discontinuation of chemotherapy.

A dose-limiting toxicity was observed in 1 patient within the first 42 days of therapy, which was grade 3 hepatitis and was deemed related to pembrolizumab in cohort C. The most common grade 3 AEs included pulmonary embolism in 3 patients (2 from cohort A and 1 from cohort C; 10%) and decreased neutrophil count in 2 patients (1 from each cohort; 10%).

Only 1 patient experienced a grade 4 AE, which was cardiac tamponade in cohort B, and 1 patient in cohort B died due to NSCLC.

Based on these findings, the 200-mg dose of canakinumab administered subcutaneously every 3 weeks in combination with the standard dose of pembrolizumab and a platinum-based chemotherapy doublet will be used in the next phase of the CANOPY-1 study, which will be a randomized double-blind, placebo-controlled phase III part to evaluate the safety and efficacy of the triplet regimen. Enrollment for this portion of the study was completed in January 2020 with 643 patients enrolled.

The primary end point of the study was DLTs in the first 42 days of treatment in order to determine the recommended phase III doses of canakinumab in combination with pembrolizumab and a platinum-based doublet chemotherapy. Secondary end points included objective response rate, duration of response, disease control rate, safety, and PK and immunogenicity.

A phase III clinical trial, CANOPY-A (NCT03447769), is underway to evaluate the efficacy and safety adjuvant canakinumab (ACZ885) in patients with nonsmall cell lung cancer (NSCLC) after complete surgical resection versus placebo, according to a presentation at the 2020 American Association for Cancer Research (AACR) Annual Meeting.2

The trial is designed to assess 1500 adult patients with completely resected NSCLC. The rationale for evaluating canakinumab, a monoclonal antibody against pro-inflammatory cytokine IL-1in this patient population is based on previous findings from the phase III CANTOS study, which evaluated the role of this agent in preventing cardiovascular events among patients with myocardial infarction who had an elevated C-reactive protein (CRP) level.

The clinical development of canakinumab as an antineoplastic agent is somewhat atypical as a particularly compelling piece of evidence supporting the potential clinical efficacy of canakinumab in NSCLC comes from a clinical study of an unrelated disease, said Edward B. Garon, MD, MS, director, Thoracic Oncology Program, David Geffen School of Medicine, University of California, Los Angeles, during his presentation at the 2020 AACR Annual Meeting.

Results from the CANTOS study, which were published in the New England Journal of Medicine in 2017, prompted interest in the agents potential as therapy in lung cancer. The trial demonstrated a highly significant reduction in lung cancer incidence, as well as mortality, in the group of patients that received canakinumab compared with placebo.3

As part of that cardiovascular study, which evaluated over 10,000 patients, the incidence and mortality from lung cancer was reduced among patients receiving canakinumab, Garon said.2 Intriguingly, this effect was dose-dependent with the greatest reduction occurring among patients treated at the highest dose level evaluated.

IL-1 is an inflammatory cytokine released by various cell types to promote tumor growth, progression, and metastasis. It upregulates tumor-association inflammation, which is known to suppress antitumor immune responses. Canakinumab targets tumor-promoting inflammation to reduce immunosuppression by binding to human IL-1 and neutralizing the activity by blocking its interaction with IL-1 receptors.2

The multicenter randomized double-blind, placebo-controlled CANOPY-A study is enrolling patients with stage IIA-IIIA and IIIB NSCLC and an ECOG performance status of 0 or 1. Patients can have any histology and must have recovered from all toxicities related to prior systemic therapy to grade 1, although patients with any grade alopecia and grade 2 or less neuropathy are allowed to enter the study as well.

If patients have unresectable or metastatic disease, they are ineligible to participate. They will also be unable to enter the study if they received neoadjuvant chemotherapy or neoadjuvant radiotherapy. If there is a presence or a history of a malignant disease besides the resected NSCLC that has been diagnosed or required therapy within the past 3 years, they could not enter the study. Patients with a history of current diagnosis of cardiac disease or uncontrolled diabetes are also ineligible.

Patients enrolled to the CANOPY-A study will undergo appropriate adjuvant therapy, which is primarily inclusive of cisplatin-based chemotherapy and in some cases radiotherapy if indicated by local guidelines or practices. Patients are randomized 1:1 to receive 18 cycles of either Canakinumab at 200 mg or placebo subcutaneously every 3 weeks.

The primary end point of the trial is disease-free survival. Secondary end points include overall survival, lung cancer-specific survival, adverse events, and EKG and laboratory abnormalities. Additional secondary end points also include PK evaluation, anticanakinumab antibodies, and health-related quality of life.

A biomarker substudy will also be conducted under CANOPY-A to determine the impact of surgical resection on biomarkers, such as CRP and cytokines. Eligibility criteria for this substudy mirror the criteria for the randomized study post-resection. Patients will undergo blood sample collection both pre- and post-surgery.

Canakinumab has already been approved by the FDA for the treatment of a spectrum of autoinflammatory conditions, such as rheumatologic disorders.3

References

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Canakinumab Plus Pembrolizumab and Chemotherapy Appears Safe in Advanced NSCLC - Targeted Oncology

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Table Of Content

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Segment by Type:

Calcium channel alpha 2-delta ligandsSerotonin-norepinephrine reuptake inhibitorsOthers

Segment by Application:

Retail PharmaciesHospitalsOthers

North America

Europe

Asia-Pacific

South America

Center East and Africa

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China, Japan, Korea, India and Southeast Asia

Brazil, Argentina, Colombia

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Neuropathy Pain Treatment Market Giants Spending Is Going To Boom - Cole of Duty

Diabetic Neuropathy Market Research Report 2020, is mostly driven by the improved taking on of Diabetic Neuropathy across small and medium-sized enterprises. Worldwide Diabetic Neuropathy Market quantifying the talk on those players at the interval. The report figures the limits and strong points of the players. To begin with the Diabetic Neuropathy Market report which covers market characteristics, industry structure and comitative landscape, the problems, desire concepts, along with business strategies market effectiveness.

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In this study, the years considered to estimate the market size of 2020-2026 Diabetic Neuropathy Market are as follows:History Year: 2015-2017Base Year: 2017Estimated Year: 2020Forecast Year 2020 to 2026

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Diabetic Neuropathy Market Global Status and Business Outlook 2018 to 2026 - Latest Herald

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Global Diabetic Peripheral Neuropathy Treatment Market Segmentation

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Diabetic Peripheral Neuropathy Treatment Market Region Coverage (Regional Production, Demand & Forecast by Countries etc.):

North America (U.S., Canada, Mexico)

Europe (Germany, U.K., France, Italy, Russia, Spain etc.)

Asia-Pacific (China, India, Japan, Southeast Asia etc.)

South America (Brazil, Argentina etc.)

Middle East & Africa (Saudi Arabia, South Africa etc.)

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Table of Contents:

Study Coverage: It includes study objectives, years considered for the research study, growth rate and Diabetic Peripheral Neuropathy Treatment market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.

Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Diabetic Peripheral Neuropathy Treatment market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.

Diabetic Peripheral Neuropathy Treatment Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.

Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.

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Diabetic Peripheral Neuropathy Treatment Market Overview, Top Companies, Region, Application and Global Forecast by 2026 - Latest Herald