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Peripheral Neuropathy Secondary to a Functional Vitamin B12 Deficiency in the Setting of Erythrocytosis - Cureus
Hand Interventions Cut Neuropathy Risk in Breast Cancer Tx Medscape
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Hand Interventions Cut Neuropathy Risk in Breast Cancer Tx - Medscape
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Steffen Peters Has New Pair of Dressage Boots Acquired After New Treatment of His Neuropathy Provides Hope of Riding Again - Dressage-News
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Cutaneous Carbonyl Stress Linked to Nerve Dysfunction and Neuropathy Risk in Recent-Onset Type 2... - Medical Dialogues
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Hypothyroidism is a condition in which the thyroid gland doesn't produce enough thyroid hormone. It is a possible but not common cause of damage to nerves outside of the brain and spinal cord, known as peripheral neuropathy.
Peripheral nerves carry information to and from the brain and spinal cord and the rest of the body, such as your arms and legs. Peripheral neuropathy occurs when the peripheral nerves become damaged. Symptoms may include pain, a burning feeling, tingling or loss of feeling in the area affected by the nerve damage. It also may cause muscle weakness or loss of muscle control.
Long-term hypothyroidism that's not treated can cause peripheral neuropathy. The link between hypothyroidism and peripheral neuropathy isn't fully understood, but hypothyroidism can cause fluid retention that leads to swollen tissues. This can put pressure on peripheral nerves.
This most commonly occurs in the wrists. The nerve responsible for hand function goes through a "tunnel" of soft tissue. This soft tissue can swell and press on the nerve, resulting in carpal tunnel syndrome. However, most people with carpal tunnel syndrome don't have hypothyroidism.
See your healthcare professional if you have or suspect you have hypothyroidism and you're having troubling or painful symptoms in your arms or legs.
Treatment of peripheral neuropathy due to hypothyroidism involves managing hypothyroidism and treating the resulting symptoms. This may include:
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Hypothyroidism: Can it cause peripheral neuropathy?
Diabetic neuropathy is a type of nerve damage that can occur if you have diabetes. High blood sugar (glucose) can injure nerves throughout the body. Diabetic neuropathy most often damages nerves in the legs and feet.
Depending on the affected nerves, diabetic neuropathy symptoms include pain and numbness in the legs, feet and hands. It can also cause problems with the digestive system, urinary tract, blood vessels and heart. Some people have mild symptoms. But for others, diabetic neuropathy can be quite painful and disabling.
Diabetic neuropathy is a serious diabetes complication that may affect as many as 50% of people with diabetes. But you can often prevent diabetic neuropathy or slow its progress with consistent blood sugar management and a healthy lifestyle.
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Diabetic neuropathy - Symptoms & causes - Mayo Clinic
Peripheral neuropathy care at Mayo Clinic
Doctors at Mayo Clinic are experts at diagnosing and treating peripheral neuropathy. They will work with your health care professional to help coordinate your treatment.
Coordinated care. Your care is discussed among the team, appointments are scheduled in coordination and highly specialized peripheral neuropathy experts are all working together to figure out what's best for you.
What might take months to accomplish elsewhere can usually be done in only a matter of days at Mayo Clinic.
Mayo Clinic doctors trained in brain and nervous system conditions, called neurologists, nervous system surgery, known as neurosurgeons, and other areas collaborate to provide your care. Mayo Clinic specialists treat more than 18,700 people with peripheral neuropathy each year.
Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Jacksonville, Florida, and Mayo Clinic in Phoenix/Scottsdale, Arizona., rank among the Best Hospitals for neurology and neurosurgery and for cancer in the U.S. News & World Report rankings. Mayo Clinic Children's Center in Rochester is ranked the No. 1 hospital in Minnesota, and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 20242025 "Best Children's Hospitals" rankings. With the emphasis on collaborative care, specialists interact very closely with their colleagues across all sites.
Learn more about Mayo Clinic's neurology and neurosurgery departments' expertise and rankings.
Mayo Clinic has major campuses in Phoenix and Scottsdale, Arizona; Jacksonville, Florida; and Rochester, Minnesota. The Mayo Clinic Health System has dozens of locations in several states.
For more information on visiting Mayo Clinic, choose your location below:
Mayo Clinic works with hundreds of insurance companies and is an in-network provider for millions of people.
In most cases, Mayo Clinic doesn't require a physician referral. Some insurers require referrals or may have additional requirements for certain medical care. All appointments are prioritized on the basis of medical need.
Learn more about appointments at Mayo Clinic.
Please contact your insurance company to verify medical coverage and to obtain any needed authorization prior to your visit. Often, your insurer's customer service number is printed on the back of your insurance card.
Sept. 02, 2023
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Peripheral neuropathy - Care at Mayo Clinic
Overview
Peripheral nerves send messages from the brain and spinal cord to the rest of the body. They help do things such as move the body's muscles for walking and sense that the feet are cold. Peripheral nerves are made of fibers called axons that are insulated by surrounding tissues.
Peripheral nerves are fragile and easily damaged. A nerve injury can affect the brain's ability to communicate with muscles and organs. Damage to the peripheral nerves is called peripheral neuropathy.
It's important to get medical care for a peripheral nerve injury as soon as possible. Early diagnosis and treatment may prevent complications and permanent damage.
With a peripheral nerve injury, symptoms may range from mild to serious, limiting your daily activities. Your symptoms often depend on which nerve fibers are damaged:
Many peripheral nerve injuries affect more than one type of nerve fiber, so you may experience a range of symptoms.
If you experience weakness, tingling, numbness or a total loss of feeling, see your healthcare professional to find out the cause. It's important to treat peripheral nerve injuries early.
Peripheral nerves can be damaged in several ways:
Other causes include narrowing of the arteries, changes in hormone balance and tumors.
People who experience physical trauma or play sports may be at higher risk of an injury that can stretch or crush peripheral nerves. People with certain medical conditions also may be at higher risk of peripheral nerve injuries. These conditions, especially diabetes, may put nerves at greater risk of compression.
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Peripheral nerve injuries - Symptoms and causes - Mayo Clinic
Autonomic neuropathy occurs when there is damage to the nerves that control automatic body functions. It can affect blood pressure, temperature control, digestion, bladder function and even sexual function.
The nerve damage affects the messages sent between the brain and other organs and areas of the autonomic nervous system. These areas include the heart, blood vessels and sweat glands.
Diabetes is the most common cause of autonomic neuropathy. It can also be caused by other health conditions, viral or bacterial infections, or some medications. Symptoms and treatment vary based on which nerves are damaged.
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Autonomic neuropathy - Symptoms & causes - Mayo Clinic
Sponsored: Relieve Your Neuropathy with Advanced Nerve And Health Center KHOU.com
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Sponsored: Relieve Your Neuropathy with Advanced Nerve And Health Center - KHOU.com
FDA clears IND application for epigenetic regulator to treat idiopathic neuropathy pain Healio
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FDA clears IND application for epigenetic regulator to treat idiopathic neuropathy pain - Healio
Diabetic Peripheral Neuropathy Market size in the 7MM was approximately USD 2,740 million in 2022, estimated DelveInsight The Globe and Mail
Signals from your peripheral nerves the nerves located outside of the brain and spinal cord are responsible for a host of functions, from perceiving sensations to allowing movements and supporting balance. But sometimes these signals get disrupted for various reasons. The result is a condition known as peripheral neuropathy.
The network of nerves in your body serves as a messaging highway, constantly carrying impulses to and from your brain. These messages tell your body to use muscles, digest food, breathe, and feel pain, among countless other things.
Peripheral neuropathy develops when this highway becomes disrupted, and nerves become compressed or damaged. It usually affects the legs, feet, arms, and hands. Peripheral neuropathy can happen at any age but is more common after age 50.
More than 100 types of peripheral neuropathy have been identified. Each type has its own causes, symptoms, and treatment options. Some types affect only one or a few nerves, while others affect many nerves in the body.
Some types of peripheral neuropathy result from inherited conditions. Others result from conditions or circumstances that arise over the course of someone's life.
In some people, the cause of peripheral neuropathy can't be pinpointed, which can make treatment more challenging. These cases are called idiopathic peripheral neuropathy.
While it is rarely life-threatening, peripheral neuropathy can greatly interfere with your ability to work, sleep, stay active, socialize, and enjoy your life.
Peripheral neuropathy can be caused by health conditions such as diabetes, rheumatoid arthritis, lupus, kidney disease, Lyme disease, shingles, and hepatitis. Other conditions that can cause peripheral neuropathy include having poor blood flow to the legs (often caused by peripheral arterial disease, or PAD), an underactive thyroid gland (hypothyroidism), metabolism problems, nutritional deficiencies, and growths or tumors that press on nerves.
Factors that can also cause peripheral neuropathy include heavy alcohol use, exposure to toxic chemicals, long-term exposure to cold, side effects of certain medications, nerve injuries from an accident, and pressure on a nerve (as with carpal tunnel syndrome), a cast, a brace, or crutches.
Inherited conditions causing peripheral neuropathy include Charcot-Marie-Tooth disease, which affects nerves in the arms, hands, legs, and feet; Friedreich ataxia, which slowly damages the nervous system; and a rare gene disorder known as giant axonal neuropathy, or GAN.
In the U.S., diabetes is the most common cause of peripheral neuropathy, eventually affecting about half of all people with this condition. It happens when high blood sugar levels the hallmark of diabetes damage nerves and the small blood vessels that nourish them.
People with diabetes need to be especially careful about managing their blood sugar, blood pressure, and cholesterol. Good management can help prevent or slow the progression of peripheral neuropathy, which mainly affects the feet and legs of people with diabetes.
Nerve damage in the feet can lead to falls, blisters, and sores. Diabetes can also interfere with the body's ability to heal, which may necessitate amputation of a toe, foot, or part of a leg.
Diabetic neuropathies can happen in both type 1 and type 2 diabetes.
Symptoms of peripheral neuropathy include:
Symptoms of peripheral neuropathy can range from mild to severe. In most cases, symptoms develop slowly over a period of time, and are often worse at night.
Because peripheral neuropathy causes a wide variety of symptoms, it isn't always easy for a doctor to diagnose. Your doctor will start by asking you about details of your symptoms, your medical and family history, and by performing a physical examination.
The doctor also may order blood tests to check for diabetes, thyroid problems, vitamin deficiencies, or liver or kidney problems. Genetic tests to check for inherited neuropathy conditions also may provide some clues.
In some cases, additional testing is helpful. For example, electromyography, or EMG, can tell how well your nerves are working. It can be done with either a nerve conduction study, which measures impulses along large nerves, or a needle exam, in which tiny needles are inserted into muscles to record their activity.
Other tests to help diagnose peripheral neuropathy include a biopsy of nerve or skin tissue, which involves removing a tiny bit of skin after a numbing injection, and a CT or MRI scan to check for a pinched nerve or growth that may be pressing on your nerves.
A muscle and nerve ultrasound is a noninvasive technique to look for severed or compressed nerves and abnormalities that may be related to a muscle or nerve disorder.
Treatment for peripheral neuropathy depends on your symptoms and what is causing the nerve damage. Treatment is often twofold: treating pain and other symptoms and treating the underlying cause.
Your doctor may prescribe medication to relieve pain and tingling. Different types of antidepressants including selective serotonin and norepinephrine reuptake inhibitors (SNRIs) like duloxetine (Cymbalta) and tricyclic antidepressants such as amitriptyline (Elavil), as well as certain antiseizure medications including gabapentin (Neurontin) and pregabalin (Lyrica), can ease these symptoms.
Over-the-counter skin patches or creams that contain lidocaine also may help. Other pain management techniques include electrical stimulation and relaxation therapy.
Although these medications and techniques can help ease symptoms, they do not heal the nerve damage. If the underlying cause of the neuropathy is treated, symptoms sometimes can resolve as nerves recover and regrow.
Tightly controlling diabetes by keeping blood sugar levels in check may help reduce or even eliminate symptoms in people with diabetes. Lifestyle changes, including quitting smoking, avoiding drugs and excess alcohol, healthy eating, and maintaining a healthy weight, may also help to relieve symptoms.
Surgery sometimes is necessary to ease pressure on a nerve, such as carpal tunnel surgery for the hands or surgery to remove a growth or tumor.
You can take steps to prevent peripheral neuropathy by:
To reduce the risk of shingles-related nerve damage, adults 50 years and older should get two doses of the Shingrix shingles vaccine. This has been shown to greatly reduce the risk of shingles and its complications, including peripheral neuropathy.
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Peripheral neuropathy: Causes, symptoms, treatment, and prevention
Sponsored: Say goodbye to neuropathy with help from NexGenEsis Healthcare KHOU.com
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Sponsored: Say goodbye to neuropathy with help from NexGenEsis Healthcare - KHOU.com