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Fancy a tea break? No, we insist, really. Because a new study has linked drinking regular mugs of the stuff to living longer. So, whether you need to take a breather from a work deadline, or want to wind down with a book before bed, a cuppa will do more than help you feel calm.

The research, published in the journal Annals Of Internal Medicine, found that people who sip on at least two cups of black tea daily experienced boosted longevity. Scientists looked at the drinking habits of more than 500,000 participants and discovered that it reduced the risk of mortality by between nine per cent and 13 per cent over a decade.

While the impact may be impressive, the reasons why are still a little unclear. It is thought that the polyphenol content of tea might be responsible for improved heart health. One thing's for sure, the researchers concluded that whether you add milk or sugar to your brew, it didn't seem to make a difference.

The study also indicates that black tea - drunk by 89 per cent of participants - could be just as beneficial as green tea. The latter has long been linked to improved wellbeing, with research showing that it can help with everything from brain function to cardiovascular health.

It builds on previous investigations by scientists into the virtues of your tea break. A previous study suggested that drinking tea could improve brain structure, helping you become more organised and efficient. Meanwhile, other research indicated that it could reduce many risk factors for heart disease, including by lowering blood pressure. Hot stuff.

Talking of warming beverages, here's what experts want you to know about Starbucks' Pumpkin Spice Latte...

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Drinking two cups of tea a day is linked to boosted longevity - Women's Health UK

Over the years, the asphalt industry has been working hard to improve the longevity of the pavements we drive on. We have acknowledged the fact that the right treatment, on the right pavement, at the right time is much more cost-effective than removing and replacing an asset once it's beyond repair. We as an industry know this, the smart asset owners know this, and yet many pavements are left to deteriorate while new roads and other needs take priority.

"Asset owners have more pavements in need of preservation than money to preserve them," John Hickey,executive director at the Asphalt Pavement Association of Oregon said. "Managers set short-term budgets in almost every sector and that has permeated the public infrastructure sector even though the considerations driving how we budget for infrastructure necessitate a long-term perspective. Even if pavement preservation budgets initially are sufficient, funding often gets diverted to what is perceived as more pressing needs. Maybe its a new pedestrian bridge or light rail system regardless of the benefit those new assets may confer, they are often paid for out of existing infrastructure funding without consideration for the long-term effects on the overall system. We tell our kids they cant get new things until they learn to take care of what they have, but we dont live by that rule when it comes to public infrastructure."

And the problem isn't getting any better.U.S. roads received aD gradein ASCE's 2021 Report Card, retaining the D they got back in 2017. Breaking down the nation's roads into four grading categories, 41.9 percent are categorized as good, 15.6 percent as fair, 22.6 percent as mediocre and 20.1 percent as poor.

So why has there been no improvement? The simple answer is perception.

"Pavements show deterioration relatively slowly and it is easy to think they will last another season or two, which will give us time to figure out a funding," Hickey says. "The obvious problem is that the newly added infrastructure often costs more than we initially estimate and it also requires preservation and maintenance. Pavement managers are in a constant battle advocating for pavement preservation funding in a system where the people who allocate the dollars want to show constituents something shiny and new."

In order to make impactful change on the lifespan of our pavements, the industry needs to continually push a long-term preservation strategy and deploy a "fix it first" mentality when it comes to our roadways.

According to the National Center for Pavement Preservation, there are nearly 4 million miles of paved public roads in the United States, valued at $1.75 trillion. The roads and other pavements in America are a huge investment and are vital for moving people and goods in an efficient manner. Yet we let them fall into a state of disrepair.

Unfortunately, there is very little new funding in the Infrastructure Investment & Jobs Act (IIJA) specifically dedicated to repair and no new requirements on highway monies for prioritizing repair on roads and bridges. Overall the law doubled down on the practice of giving states immense flexibility with the bulk of their money and then hoping that they use that flexibility to prioritize repair.

States should consider a "fix it first" approach to using these funds.

"In 2017, the Oregon Legislature passed a major infrastructure funding bill that had multiple funding mechanisms to adequately pay for, among other things, improving bridge seismic resiliency and preserving pavements," Hickey says. "But, the final bill included earmark projects in primarily urban areas, which are notorious for taking a long time and being expensive."

As inflation continues to be a challenge for State DOTs, it they truly want to do more with less money, preservation is the answer.

If inflation wasnt bad enough, as pavement conditions decline, pavement preservation costs increase. So what are the solutions to keep up with continual pavement decline?

In Oregon, it's Thinlays.

"Thinlays are the most beneficial pavement preservation technique," Hickey says. "Added structure and improved smoothness are probably the two Thinlay benefits that are most relevant since we need pavements to support increased loading and improved smoothness can result in a significant reduction in greenhouse gas emissions from vehicles."

Thin asphalt overlays are a reliable way to restore smoothness and drivability to an aging pavement, while correcting distresses and even adding structural value in some instances.Typically, a thin asphalt overlay is a surface mix of 1.5 inches or less placed on a well prepared surface. The pavement being overlaid may be milled or unmilled, but it should not show signs of structural distress requiring a more extensive rehabilitation.

The decision to apply a thin overlay to an existing pavement surface should be made only after a careful evaluation of the pavement condition and the elimination of the need to perform a structural rehabilitation. You also need careful consideration of an entire pavement maintenance program, otherwise costs can creep up on you.

"The primary challenge in implementing a Thinlay pavement preservation program is the fact that they often have a higher initial cost and it is hard for pavement managers to overcome the budgeting hurdles described above," Hickey says. "Marion County in Oregon is an example of an agency that has had success implementing a Thinlay program, which has improved pavement conditions and set the County up for lower pavement preservation costs over the long-term."

One of the biggest benefits of asphalt pavements is their ability to be built upon, year over year, while maintaining structural strength.

"Perpetual Pavement" is the name coined to describe a layered, flexible pavement design and construction concept. Application of the concept produces a deep-strength asphalt pavement that can resist structural fatigue distress for a long time (at least 50 years) and, thus, results in a long-lived pavement. These long-lasting structural bases can be economically maintained by replacing just the surface, never needing total removal and replacement.

Perpetual pavements are designed to develop distresses from the top-down, rather than from the bottom-up. This preserves the integrity of the bottom layers of the pavement structure, and confines damage to the top layer where it can be easily managed without requiring full-depth repairs or major rehabilitation. In fact, we now know that asphalt pavements can be designed toneverdevelop bottom-up fatigue-related distress, regardless of how many loads are applied to the pavement, and how heavy those loads may be.

By confining damage to the top layer of the pavement, maintenance and rehabilitation costs over the life of a perpetual pavement are significantly reduced. And given the fact that the lower layers of pavement are preserved, the structural life of a perpetual pavement is on the order of 50 years or more, rather than the 20-year life expectancy that has traditionally been the standard.

The cost savings and increased life expectancy are huge benefits that smaller agencies and local governments cant afford to ignore. Both high-volume highways and interstates and low-volume county roads and city streets can reap the benefits of perpetual pavement too, even if those structures were not originally designed or built to perpetual specifications. Perpetual pavement can, in fact, be achieved by increasing pavement thickness one inch of asphalt at a time.

For local agencies with limited budgets, that extra inch of asphalt will pay for itself many times over by reducing long-term maintenance costs and doubling the life expectancy of the road itself.

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How the Asphalt Industry Can Improve Pavement Longevity - For Construction Pros

Many pastors, particularly newbies, have a noble aspiration to stay long term in a church. I think it is safe to say that most of us know the value of serving long-term in one place. It gives us the privilege of journeying with people as they travel through different seasons of lifesomething not possible with short-sprint ministries. It also provides the opportunity to bring about deep and long-lasting change in a church.

For many of us, long-term ministry is a dream that turns into a nightmare.

Then the harsh realities of pastoral ministry hit us like a speeding freight train. We find ourselves looking for an exit; for greener pastures somewhere else.

Too often, people enter church ministry with blissful naivety; without recognising and weighing up the cost of staying in a church long term. Its like people who love the thrill of climbing Mt Everest but who fail to understand how much it costs to get to the top. If we want to last the distance, we need to take a hard and honest look at how much it will cost us and ask if we are prepared to pay that price. So what is the cost we need to be aware of? Here are three parts to it:

We all love speed. We are always looking for things to happen faster and faster. Faster internet. Faster fast food. Faster computers. Faster microwave food. Things need to move faster. Top Guns Maverick sums it up: I feel the need; the need for speed.

If we plan to serve in one church long term, then we have to sacrifice our need for speed. Changing and growing a church can be very very very slow and by slow I mean more than a few months or even a year. Sometimes it takes decades.

Changing and growing a church can be very very very slow. Sometimes it takes decades.

I remember speaking to a young pastor who was excited about his new church. Six months into it he was still excited. After two years he was ready to pull the plug.

Of course, some churches seem to change faster than a speeding bullet. But many others move at snails pacepainfully slow for speed-lovers. But why should we be surprised? Churches are not like speed boats that can do 180-degree spins at the drop of a hat. They are like ocean liners that take a long time to change course.

Churches come with traditions, practices, values and customs that have accumulated over yearsmaybe even centuries! It will take time to decipher them, let alone change them. To think we can change the church overnight (or even in a year or two) is crazy. Just earning peoples trust will take longer than that: As the saying goes, It is hard to earn a persons trust. But it can be easily lost overnight.

However, if slowness is a problem for us, we need to remember that it isnt for God. He was prepared to wait until Abram and Sarai were old before miraculously providing their first child. He was prepared to wait 400 years before bringing Israel out of Egypt (Gen 15:12-16). He was prepared to wait 80 years before using Moses for that job. God has his own timing.

Yet things are usually happening in the meantime. When things are slow, we need to recognise that God is still at work, changing people every minute of the day in quiet and subtle ways. Even in the most hardened of churches, the Spirit of God will use the Word to bring about Christ-like transformation. It is worth remembering the book of Ruth: as the whole nation of Israel was going down the toilet (see Judges), God was at work in a country village, bringing together a Ruth and Boaz, through whom David and his greater Heir would come to the rescue.

Who likes to fail? Success is something we pursue and celebrate. We put our successful leaders on pedestals and urge everyone to be like them.

Unfortunately, church ministry often sings to a similar tune. We pick successful pastors to be guest speakers at our church growth conferences, clinging to the worldy hope that we might be able to copy their formula. Notice that one of the key questions in strategic planning is, What does success look like?

Now, Im not against being successful, and I certainly dont want to be someone who cuts down tall poppies. It is important to plan for success. But we need to remember that success is something God gives us. He may use our planning and effort, but he does not depend on them. Success is up to God, not us (see 1Cor 3:5-9).

If we are serious about long-term ministry, we need to know and be prepared for a string of failures.

If we are serious about long-term ministry, we need to know and be prepared for a string of failures. There will be people we will fail. Many sermons will go down like lead balloons. We will make wrong (if notbad) decisions that will hurt people. We will fail to give some people the attention they need. People will complain about our boring meetings. We may fail to disciple people; fail to raise up leaders; fail to visit the sick; fail to evangelise our community; fail to raise money; fail to find extra staff. We might lose our cool or say the wrong thing that causes people to leave the church.

Failure is part and parcel of any long-term ministry. This is not an excuse for failure. It is simply to recognise that we will not always get it right. Indeed, many times we will get it wrong.

That might demoralise us. A string of failures and mistakes might make us want to pack our bags and move on. But if we are serious about staying, we will have to pick ourselves up and keep pushing on. We also need to remember that while no one loves to be a failure, God loves failures and died for them. We need to remember that our failures should not define us, nor do they need to be the end of the world (though some moral failures will disqualify us from ministry).

Yet, what ultimately defines us is not what we fail to do for God but what God has successfully done for us. He loved us, not because we were so good, but quite the opposite. Remember Pauls words in 2 Cor 11:16-33. As the super-apostles paraded their super credentials, Paul paraded his failures and weaknesses. As he reminds us, it is when we are weak that Gods grace is more than sufficient. 2 Cor 12:9.

Our natural instinct for self-preservation makes us want to avoid pain at all costs. But if we are serious about long-term ministry, we will need to be prepared for hurt that will come time and time again. Many of us have a dreamy view of ministry; that it is all fun and games. If we talk about suffering, we think of it as the sort of suffering we have to endure to get fit.

But long-term pastoral ministry is not for the faint-hearted. People will complain and criticise and often unfairly. They will complain about your preaching, your leadership, your decisions, your dress code, your manner, your pay, and your attitude. People you have depended on will turn against you and stab you in the back. Church leaders will gang up on you because you are trying to do the right thing. Although you are trying to serve the church, some people will think you are leading them to deaththink about Moses. Of course, we are not Moses, but many of us probably have an idea of how he must have felt.

But again, why should we expect anything different? Although the church is Gods holy people, they are still a bunch of ratbag kids who need to grow up to become like Christ. In his graciousness, God has given us a part in this. But as any parent will tell you, raising children can be painful. In Galatians 4:19, Paul even likens his efforts to the pains a mother goes through in giving birth to a baby. This is the pain he feels until Christ is fully formed in the church. It is hard enough to endure birth pangs for an hour or two. Imagine 20 years of them!

If we are serious about long-term ministry, we need to be prepared for the years of such pain. Are we prepared to pay this cost? We need to be if we are serious about long-term ministry.

And yet, if we are serious, Gods grace and power will prove to be more than sufficient to sustain us to the very end. As Paul wraps his ministry and passes the baton to Timothy, he encourages him with these words:

For this reason I remind you to fan into flame the gift of God, which is in you through the laying on of my hands. For the Spirit God gave us does not make us timid, but gives us power, love and self-discipline. So do not be ashamed of the testimony about our Lord or of me his prisoner. Rather, join with me in suffering for the gospel, by the power of God.(2 Timothy 1:6-8, NIV)

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Longevity: Playing the Long Game in Ministry - The Gospel Coalition

New Delhi: Widely considered one of the most significant figures of the second half of the 20th century, Mikhail Gorbachev, the last president of the Soviet Union passed. Gorbachev, credited with ending the Cold Wat without any bloodshed lived till the age of an astounding 91 years, even though was suffering from long and a serious illness that has always been shrouded in mysteries. Earlier this year Gorbachev, whose biggest contribution was to provide Russians with freedom of speech and multi-party democracy, had been hospitalized for an unknown kidney ailment, which media reports said was dialysis treatment but was refuted by the Tass. The cause of his death has not been announced yet.

A few years back, Australian media had also said he was suffering from severe diabetes, a claim not verified.

Secrets of Gorbachevs longevity

According to the Tass, the Nobel Prize winner will be buried in Moscow's Novodevichy cemetery, next to his wife Raisa.

Unabashed love for family and celebration of bondsGorbachev was married to Raisa for 46 years before she died of leukemia in 1999. In the volumes of his memoirs, which he had dedicated to her, Gorbachev had mentioned being heartbroken by her death. He loved traveling and used to take short breaks with his family to rejuvenate and recuperate from the stressful work times.Gorbachev's memoirs also feature pictures from the various family holidays taken in and outside Russia.

Love of Music: A great stress buster

In the dark night, I know that you, my love, are awake, sitting by the crib you're secretly wiping away a tear; How I love your deep gentle eyes, how I want to press my lips to yours," he sang for an interview to the BBC way back in 2013.

Unfailing sense of humor

Gorbachev was also known for his humorous takes on serious politics. According to various journalists who interviewed him, especially after he left office, Gorbachev used to take a dig at himself quite often. "Look, now I need three legs to get around!" He told BBCs Steve Rosenberg in Moscow after he started using a stick to walk around. "What happened to the USSR was my drama. And a drama for everyone who lived in the Soviet Union," he chuckled as he spoke about the fall of the USSR.

Link:
Know 3 longevity secrets of the last USSR President Mikhail Gorbachev who died at the ripe age of 91 - Times Now

Longevity is an important aspect and factor when it comes to evaluating all-time athletes in any sport. The ability to maintain one's greatness is important, as it shows that someone can be a winning player over a period of time rather than having a short peak and a worse overall career.

There are a lot of legends playing professional sports currently that have elite longevity. Tom Brady is still a good quarterback in the NFL, Serena Williams has recently moved on to the third round of the 2022 US Open after upsetting her opponent, while LeBron James is still a superstar in the NBA. We are witnessing greatness all around.

Recently, Philadelphia 76ers guard Tyrese Maxey offered some praise for LeBron James, Serena Williams, and Tom Brady and their longevity. He jokingly asked about what is "in the water" that those three athletes are drinking, and it's clear that Maxey is amazed atwhat those legendary stars have been able to accomplish.

What is in the water Bron, Serena, and TB12 drinking!? At this point Im just curious!

There is no doubt that those athletes have had long and productive careers and will retire as legends of their respective sports. Most NBA fans know that LeBron James' longevity in the sport is absolutely unprecedented. Once, former player Eddie Johnson pointed out that players such as Magic Johnson and Larry Bird were "no longer relevant" by the time they were LeBron James' age, and noted that this "lets you know how great" James actually is.

Its amazing how LeBron at almost 37 is still being ripped for struggling, when he has an AD in his prime and not living up to expectations. Magic, Bird, Duncan, Hakeem, and Jordan were no longer relevant at 37. That lets you know how great LBJ is. Keep it moving."

Hopefully, we see LeBron James have another good year with the Los Angeles Lakers next year. While the team missed out on the playoffs this past season, they have revamped their roster, and perhaps that will lead to a different outcome for the next year.

As for Tyrese Maxey, he will likely be focused on trying to win a championship with the Philadelphia 76ers. Many expect him to become the third star of the franchise behind James Harden and Joel Embiid, and he definitely has the talent to do so.

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Tyrese Maxey Lauds LeBron James, Serena Williams, And Tom Brady For Their Longevity: "What Is In The Water Bron, Serena, And TB12...

Auckland: New Zealand left-arm seamer Mitchell McClenaghan is worried of senior players not being valued much by the New Zealand Cricket (NZC) upon reaching a certain age.

McClenaghans fears come after pace all-rounder Colin de Grandhomme announced his retirement from international cricket on Wednesday.

A veteran of 29 Tests, 45 ODIs and 41 T20Is who played an integral hand in the success of New Zealand in recent times, de Grandhomme was selected by the Adelaide Strikers ahead of season 12 of the Big Bash League (BBL) through an inaugural overseas draft. De Grandhomme, 36, follows in the footsteps of Kiwi left-arm pace bowler Trent Boult, who too was granted a release from his central contract by NZC.

Also Read: Hope Next Year He is Not Worried About the Orange Cap

I think once youre at a certain age, youre not really valued at New Zealand Cricket. I feel like there should be some reward for longevity in this game, particularly with the way the contracts are set up with NZC.

Youre on a year-by-year contract so theres actually no security at all. Youre not an employee like you are with New Zealand Rugby, where youre on a longer-term contract where you dont need to look over your shoulder and youre on good money, said McClenaghan on SENZ Breakfast show.

McClenaghan, who played 48 ODIs and 29 T20Is for New Zealand, feels that lack of security in NZC contracts was why de Grandhomme announced his retirement from international cricket after bagging a BBL deal with Strikers.

You could lose your job tomorrow so all your security is out the window, so I can understand why Colin waited until he had a job to go to before kicking it in. I think in his mind he probably thought hed have four or five Tests left at a max and then that (would) probably be taken towards the end of his career. Thats just the nature of being a contractor unfortunately for NZC and obviously for New Zealand cricketers as well.

ASIA CUP 2022:FULL COVERAGE|SCHEDULE|RESULTS

New Zealand will be next seen in action in a three-match ODI series in Australia starting from September 6.

Get the latest Cricket News, Schedule and Cricket Live Scores here

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'There Should be Some Reward for Longevity in This Game'-Kiwi Pacer Wants Change In Central Contracts - News18

On Friday, August 26, the CSUF Kinesiology and Public Health departments honored 33 esteemed emeriti by unveiling a portrait wall in the KHS building.

Bill Beam, kinesiology professor and chair emeritus (1983-2015) was instrumental in planning the event, bringing together alumni, current and former faculty, community members, college leadership, and, of course, the emeriti and their families.

Many notable CSUF emeriti were present for this event whose individual contributions include authoring world-class books on diving, receiving national recognition for research in veterans health and employee education for the U.S. Department of Veterans Affairs, and breaking the Chicago Cubs 108-year curse.

What a great way to honor our early leadersthe movers and shakers who brought us where we are, said Michele Wood, chair of public health. Public health started as a track in kinesiology. We are now working to establish a mental health and well-being scholarship, and re-envisioning HPRI into an entity that focuses on health equity and resilience. As a department, we are engaged, we are vibrant, we are productive, and we are mentoring future leaders.

Among the phrases that come to mind when one is honoring the people whose work, in this case, teaching, research, and service as well as their collegiality, have paved the way for those who have followed, is to say that we stand on the shoulders of giants,' said Steve Walk, chair and professor of kinesiology. While this phrase is apt, one also considers the often-used image of the tree, in our case the orange tree seen in our campus seal, for embodying longevity and wisdom, bearing the fruit that supports generations to come, establishing roots that ensure health, solidity, and longevity, and recording in its very core the successes and challenges of the past. And lets be honest, for a long time, physical education struggled for a security of place in higher education, strove to overcome cultural stereotypes, intellectual prejudices and associated hierarchies, and in its work to become kinesiology, almost came apart at the seams on some campuses. Not so much at Cal State Fullerton. Your work to build the department was done in the context of these challenges, and its successes are a testament to your shared beliefs and commitment to working collegially to bring them about.

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Kinesiology and Public Health Emeriti Honored | CSUF News - CSUF News

Two experts from Cleveland Clinic explain how a new cell-based gene therapy is helping patients with certain types of leukemia, with research into potential wider applications continues.

As World Leukemia Day approaches on 4 September, experts from global health system Cleveland Clinic are working on new immunotherapy treatments for blood cancers such as leukemia, expanding treatment options and bringing hope to patients for whom other treatments have failed.

Leukemia is a group of cancers characterized by rapid, uncontrolled growth of abnormal blood cells called leukemia cells. It can occur in children and adults and according to the World Cancer Research Fund International, it is the 13th most prevalent cancer globally.

According to Jan Joseph Melenhorst, PhD, a translational immunologist who is Director of Cleveland Clinics recently established Cell Therapy and Immuno-Engineering Program, chimeric antigen receptor (CAR) T-cell therapy is profoundly changing the treatment landscape, bringing the promise of durable remission for many patients with blood cancers such as leukemia.

Dr-Jan Joseph-Melenhorst

CAR T-cell therapy is a specialized treatment using a patients own T-cells a type of white blood cell that forms part of the immune system.

The T-cells are extracted and genetically modified so that they can recognize and destroy cancer cells, before being multiplied and infused back into the bloodstream, explains Dr. Melenhorst, who is also Vice Chair of the Center for Immunotherapy and Precision Immuno-Oncology at Cleveland Clinic.

He added that while CAR T-cell therapy has brought new hope for many patients, there are currently several challenges to overcome in administering the treatment.

In particular, it may be more expensive than other therapies. Additionally, it has potentially serious side effects.

This limits access to treatment as the therapy needs to be administered on an inpatient basis at a specialized facility where the side effects can be managed. We are working with Clevelands Case Western Reserve University and other parties and collaborating with various manufacturers to address issues such as accessibility, safety, and costs, he says.

Dr. Melenhorst and his team are also aiming to improve the efficacy of existing CAR T-cell therapies while developing new versions for a wide range of blood and other cancers.

Their colleague, Craig Sauter, MD, is a hematologist and Director of Blood and Marrow Transplant at the Cleveland Clinic who has been using CAR T-cell therapy to successfully treat patients with leukemia and other blood cancers where other treatments have failed.

The standard of care in initial therapy for many acute leukemia patients remains cytotoxic chemotherapy, with the aim of achieving remission. In cases where first-line chemotherapy or other treatments have failed, however, CAR T-cells provide another potential treatment option for patients with B-cell acute lymphoblastic leukemia. In the FDA-approved indications, it has proved much more effective than the previous standard, which was a further round of chemotherapy, he says.

The U.S. Food and Drug Administration (FDA) has approved commercial CAR T-cell products for several types of blood cancers including acute lymphocytic leukemia (ALL) in patients who have been resistant to other treatments or whose cancer has returned after a period of remission. Clinical trials are also underway at institutions including Cleveland Clinic for CAR T-cells to treat acute myeloid leukemia (AML).

ALL and AML are two of the four main types of leukemia. The disease is classified as acute or chronic based on how rapidly the disease spreads in the body, and as myeloid or lymphocytic depending on whether the leukemia cells arise from myeloid cells, which develop in bone marrow, or from lymphoid cells, which are related to the immune system.

Dr. Craig Sauter

Explaining how the procedure works in practice,

Dr. Sauter says the first step is to extract the patients lymphocytes and insert an inactive virus that delivers new genetic instructions to the T-cells to start producing chimeric antigen receptors targeting proteins that live on the malignant cells.

Researchers take a small batch of these newly altered CAR T-cells and induce them to grow and multiply until there are enough to effectively target cancer cells.

The CAR T-cells are frozen and stored until the patient is ready to receive them. To prepare for the infusion, the patient receives a mild form of chemotherapy to prevent the immune system from rejecting the CAR T-cells.

According to Dr. Sauter, most people need to stay in the hospital for one to two weeks so their response to the treatment can be monitored and any side effects treated. The two most common side effects of CAR T-cell therapies are cytokine release syndrome (CRS) and neurological problems such as headaches, confusion, or difficulty speaking during the treatment period.

Dr. Sauter points out CAR T-cell therapy is in its early phase, but he is cautiously optimistic about its potential. In future, as a result of further research and carefully conducted studies, there may be an opportunity to identify high-risk groups who may benefit from having CAR T-cell therapy over chemotherapy in earlier lines of treatment, he says. The possibility of its application being extended to treat other forms of cancer is also very exciting.

Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education. Located in Cleveland, Ohio, it was founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation. Cleveland Clinic has pioneered many medical breakthroughs, including coronary artery bypass surgery and the first face transplant in the United States.

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Hope For Leukemia Patients, Where Other Treatments Have Failed - Longevity LIVE - Longevity LIVE

The researchers evaluated changes in DNA methylation and discovered that hibernation slows biological aging.

The big brown bat, which is the most common type of bat in the United States, has an incredibly long lifespan of up to 19 years. One of the secrets to this bats exceptional lifespan has been discovered by a recent study headed by scientists at the University of Maryland: hibernation.

Hibernation has allowed bats, and presumably other animals, to stay in northerly or very southerly regions where theres no food in the winter, said the studys senior author, UMD Biology Professor Gerald Wilkinson. Hibernators tend to live much longer than migrators. We knew that, but we didnt know if we would detect changes in epigenetic age due to hibernation.

The scientists discovered that a big brown bats epigenetic clocka biological marker of agingis extended by three-quarters of a year by hibernating for one winter. Scientists from McMaster University and the University of Waterloo, both in Ontario, Canada, were also involved in the research, which was publishedin the Proceedings of the Royal Society B.

Big brown bats can live up to 19 years. Credit: Brock and Sherri Fenton

Small tissue samples from the wings of 20 big brown bats (Eptesicus fuscus) collected across two periodswinter when they hibernated and the summer when they were activewere analyzed. The bats were housed in a research colony at McMaster University and ranged in age from less than a year to a little more than ten years.

The samples were then compared with samples obtained from the same animal during active and hibernating phases to determine changes in DNA methylation, a biological process connected to gene regulation. They revealed that certain sites in the bats genome had changes in DNA methylation, and these sites seemed to be impacting metabolism during hibernation.

Its pretty clear that the sites that decrease methylation in the winter are the ones that appear to be having an active effect, Wilkinson said. Many of the genes that are nearest to them are known to be involved in regulating metabolism, so they presumably keep metabolism down.

Some of these genes were identified as longevity genes by Wilkinson and colleagues in a previous study. According to Wilkinson, there is considerable overlap between hibernation genes and longevity genes, highlighting the relationship between hibernating and longer lifespans.

The previous study also created the first epigenetic clock for bats, which can reliably predict the age of any bat in the wild. This clock was used in the current study, allowing the researchers to show that hibernation decreases a bats epigenetic age when compared to a non-hibernating animal of the same age.

Studies like this one help to explain why bats have longer lives than would be expected for a small mammal the size of a mouse. They do, however, raise new questions.

We still dont have a very good understanding of why some bats can live a really long time and other ones dont, Wilkinson said. Weve shown that the ones that live a really long time all share the ability to hibernate or to go into torpor frequently. That seems to be a corollary, but its not sufficient because hibernating rodents dont live 20 years.

Wilkinson said he is planning a follow-up study to compare epigenetic aging in big brown bats in Canada, where they hibernate, with the same species in Florida, where they do not hibernate. In doing so, Wilkinson hopes to get an even clearer picture of the role that hibernation plays in prolonging lifespans.

Reference: Big brown bats experience slower epigenetic ageing during hibernation by Isabel R. Sullivan, Danielle M. Adams, Lucas J. S. Greville, Paul A. Faure and Gerald S. Wilkinson, 10 August 2022, Proceedings of the Royal Society B Biological Sciences.DOI: 10.1098/rspb.2022.0635

The study was funded by the American Society of Mammalogists, Sigma Xi, the University of Maryland, and the Natural Sciences and Engineering Research Council of Canada.

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Researchers Discover the Secret to a Small Mammals Exceptional Lifespan - SciTechDaily

I enjoy a good streaming service, be it Netflix, Disney+, or Amazon Prime. Admittedly, one of my favorite places to log in, and the stream is from my bed. However, one thing Im not guilty of is falling asleep while catching up on the latest episode of Squid Game. In fact, it appears that I was protecting my longevity when doing this, as a new study has revealed that falling asleep in front of the TV could lead to an early death.

The study, published in Sleep, set out to find a link between late at night activities in older adults in the U.S. and its association with cardiovascular disease (CVD) risk factors. For the study, researchers from the Northwestern School of Medicine examined the impact of ambient light on the health and sleeping habits of 552 people between the ages of 63 and 84.

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The findings revealed that participants who slept under ambient light were more likely to experience hypertension, diabetes, obesity, and insulin resistance in the morning. In fact, 17.8% of the participants who slept with the TV on suffered from diabetes, compared to only 9.8% who didnt sleep with the TV on. Also, 40.7% of participants who slept under ambient light were obese, compared to the 26.7 who were also obese but slept in darkness.

For the team, the results of the study can be linked back to the fact that sleeping under ambient light affects glucose regulation, and insulin resistance has been associated with Type II diabetes, cardiovascular disease, and hypertension.

According to a previous study published in PLOS Medicine, extreme obesity can shorten your lifespan by 14 years. Additionally, research has also found that people with type 2 diabetes, on average, have a shorter life expectancy of about 10 years.

In addition to the aforementioned findings, the study also revealed that participants who fell asleep in ambient light were more likely to stay awake later and then sleep later the next day.

We know late sleepers tend to also have a higher risk for cardiovascular and metabolic disorders, Lead researcher Phyllis Zee told CNN.The saying the early bird catches the worm is anything but a common expression. In fact, one 2018 study suggested that night owls have a 10% heightened risk of early mortality.

People should do their best to avoid or minimize the amount of light they are exposed to during sleep, Phyllis Zee, CNN

Its not just your TV habits that are a cause for concern at night, as any screen that emits blue light can affect your sleep health, which in turn can compromise your longevity. If youre worried about your devices affecting your sleep hygiene, then heres how you can safely use your tech at night.

Tech at night tips:

At 46 years old, Eva Longoria is truly the embodiment of health and wellness. As the years go by, the Desperate Housewives actress continues to prioritize her longevity. In fact, she recently shared two health habits that had changed in her 40s, and these two could be the key to why shes aging so well: eating well and sleeping well.

Kitahara, C. M., Flint, A. J., Berrington de Gonzalez, A., Bernstein, L., et al. (2014). Association between class III obesity (BMI of 40-59 kg/m2) and mortality: a pooled analysis of 20 prospective studies.PLoS medicine,11(7), e1001673. https://doi.org/10.1371/journal.pmed.1001673

Kim, M., Vu, T. H., Maas, M. B., Braun, R. I., Wolf, M. S., Roenneberg, T., Daviglus, M. L., Reid, K. J., & Zee, P. C. (2022). Light at night in older age is associated with obesity, diabetes, and hypertension.Sleep, zsac130. Advance online publication. https://doi.org/10.1093/sleep/zsac130

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Falling Asleep With The TV On Is Affecting Your Longevity - Longevity LIVE - Longevity LIVE

Climate change and longevity are inextricably. linked. Theres a significant health threat associated with changing weather patterns and some geographies may be harder hit than others. The danger is all encompassing.

Increasingly, leaders in the healthcare industry are raising their concerns about the impact climate change is already having on healthcare projections. Mustafa Kamel, Medical Affairs Director for Janssen South Africa is outspoken about his concerns. He says the time to act is now!

The world has already warmed by more than 1C. We can still limit temperature rise to 1.5C & avoid the worst climate impacts. But we need more ambition now.

At the tail-end of the Covid-19 pandemic, the worlds gaze has shifted to climate change and the impact that it would have in the near, medium and longer-term future. It is a stark reality and variations in severity are expected to be unequally distributed around the globe. Some places may become colder, but balanced out by other regions experiencing warmer winters, for example. Included in the package, more frequent and severe weather conditions. And we have already seen these phenomena emerge.

Just as temperature and weather changes will be distributed unequally, so too will the impact of climate change be disproportionately scattered.

Sadly, population segments most at risk would be those who are most vulnerable. These include lower-income communities, children and pregnant women, senior adults, persons with disabilities and pre-existing conditions amongst others. These risks are complex.

As Kamel notes, Think about what all of this really means. Just imagine your daily life. Clean drinking water, the air we breathe, the food that we eat, the flights we take and the fossil fuels we consume. We created this monster, and now we must deal with it.

Theres no question that climate change will bring about a significant impact on health and healthcare, too. In many instances, it is along the value chain such as food security, which is paired with nutrition, and in turn the associated diseases and conditions that may emanate. These may include increased risk of cancer, dental problems, weight gain and appropriate growth in children, mental health challenges and diabetes, amongst others.

Ground level Ozone, or smog, holds several respiratory dangers and consequences can include lung conditions, asthma, or compounded as a pre-existing condition, while water-borne threats like cholera could become more widespread. Diseases previously thought under a measure of control, like Malaria, could begin to spread again in previously eradicated areas. Lyme disease and dengue fever also count amongst ecologically-based diseases that may make an unwelcome return. The list of mild to severe impact on the wellness of the world is substantial. Mustafa Kamel, Medical Affairs Director for Janssen South Africa

Add to this the direct consequences of climate change that we have seen rearing its head already. Instances of heatwaves where sunstroke, cardiovascular failures and other related deaths occur. Flooding, like we have recently seen in many parts of the world causes damage to property, injury and death to people.

While endeavours to slow climate change continues to be on the global agenda, it is imperative that action be taken. And its not simply about reducing carbon emissions. It is also about the damage to the environment through activities like deforestation, over-grazing, waste management and the like. In fact, almost every aspect of our lives would have to shape-shift responsibly in a collective attempt to counter a tsunami that humanity has started. Now it is up to us to manage its severity.

We would be saving ourselves, said Kamel, And while the full impact of climate change may only be a scientific guessing game at present, governments around the world have taken note and are planning to meet the potentially inevitable. Healthcare is no different.

To effectively manage the impact of pressure on healthcare, said Kamel, it is imperative that greater emphasis be placed on primary healthcare. This is particularly true for emerging markets and countries where low-income population segments and unemployment or poverty is rife. South Africa is at risk.

Significant investment and round-table collaboration between role players is now more critical than ever. It requires national policy changes, and a collaborative effort between authorities, the pharmaceutical industry, healthcare practitioners, the private hospital sector and wellness organisations.

The opportunity cost is potentially enormous. Already the World Health Organisation estimated that by 2030, the cost of direct damage to health because of climate change could be between two to four billion dollars, and that excludes ancillary price tags of clean water and sanitation for example. The institution also projected an additional 250 000 deaths annually between now and 2050, directly related to the impact of climate change.

Kamel said that primary healthcare is where illness or disease can be treated most effectively, and progressive infections as well as their impact can be managed at the genesis of a disease. He notes,

Climate change is the biggest threat to humanity and life as we know it. Lets do something about it, now.

Longevity shares the global concern about the climate crisis. You can read more here: We cannot be Pro-Aging without a healthy planet

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Climate Change and Longevity Go Hand in Hand - Longevity LIVE - Longevity LIVE

The researchers created a digital model of psychology aimed to improve mental health. The system offers superior personalization and identifies the shortest path toward a cluster of mental stability for any individual.

Deep Longevity has published a paper in Aging-US outlining a machine learning approach to human psychology in collaboration with Nancy Etcoff, Ph.D., Harvard Medical School, an authority on happiness and beauty.

The authors created two digital models of human psychology based on data from the Midlife in the United States study.

The first model is an ensemble of deep neural networks that predicts respondents chronological age and psychological well-being in 10 years using information from a psychological survey. This model depicts the trajectories of the human mind as it ages. It also demonstrates that the capacity to form meaningful connections, as well as mental autonomy and environmental mastery, develops with age. It also suggests that the emphasis on personal progress is constantly declining, but the sense of having a purpose in life only fades after 40-50 years. These results add to the growing body of knowledge on socioemotional selectivity and hedonic adaptation in the context of adult personality development.

The article describes an AI-based recommendation engine that can estimate ones psychological age and future well-being based on a constructed psychological survey. The AI uses the information from a respondent to place them on a 2D map of all possible psychological profiles and derive ways to improve their long-term well-being. This model of human psychology can be used in self-help digital applications and during therapist sessions. Credit: Michelle Keller

The second model is a self-organizing map that was created to serve as the foundation for a recommendation engine for mental health applications. This unsupervised learning algorithm splits all respondents into clusters depending on their likelihood of developing depression and determines the shortest path toward a cluster of mental stability for any individual. Alex Zhavoronkov, the chief longevity officer of Deep Longevity, elaborates, Existing mental health applications offer generic advice that applies to everyone yet fits no one. We have built a system that is scientifically sound and offers superior personalization.

To demonstrate this systems potential, Deep Longevity has released a web service FuturSelf, a free online application that lets users take the psychological test described in the original publication. At the end of the assessment, users receive a report with insights aimed at improving their long-term mental well-being and can enroll in a guidance program that provides them with a steady flow of AI-chosen recommendations. Data obtained on FuturSelf will be used to further develop Deep Longevitys digital approach to mental health.

FuturSelf is a free online mental health service that offers guidance based on a psychological profile assessment by AI. The core of FuturSelf is represented by a self-organizing map that classifies respondents and identifies the most suitable ways to improve ones well-being. Credit: Fedor Galkin

A leading biogerontology expert, professor Vadim Gladyshev from Harvard Medical School, comments on the potential of FuturSelf:

This study offers an interesting perspective on psychological age, future well-being, and risk of depression, and demonstrates a novel application of machine learning approaches to the issues of psychological health. It also broadens how we view aging and transitions through life stages and emotional states.

The authors plan to continue studying human psychology in the context of aging and long-term well-being. They are working on a follow-up study on the effect of happiness on physiological measures of aging.

The study was funded by the National Institute on Aging.

Reference: Optimizing future well-being with artificial intelligence: self-organizing maps (SOMs) for the identification of islands of emotional stability by Fedor Galkin, Kirill Kochetov, Michelle Keller, Alex Zhavoronkov and Nancy Etcoff, 20 June 2022, Aging-US.DOI: 10.18632/aging.204061

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Harvard Developed AI Identifies the Shortest Path to Human Happiness - SciTechDaily

LIV Golf made its U.S. debut in Portland on Thursday, and if the scene at Pumpkin Ridge Golf Club "proves anything, its this: everyone at LIV is convinced its here to stay," according to Dylan Dethier of GOLF.com. To hear them tell it, the players are "thrilled to be" on the tour. Whatever "you may think of LIV, thats crucial to understanding its future; the pros will be its most effective advocates and recruiters going forward, and happy pros will attract others." Bryson DeChambeau was "delighted at the possibility of bringing his production company inside the ropes alongside him for content capture." He said of LIV, Anything we ask for, theyre allowing us to do." Meanwhile, this week the "fan-free practice rounds were particularly low-key, with friends and teams roaming freely across the grounds."Agents, managers and coaches are "welcomed on the fairways." One coach "remarked that LIV is more welcoming than any tour hes ever been on." He said, You have actual human rights out here. The music "cascading over the driving range was an engaging touch, as were the speakers set up every few holes." There were "tense moments in press conferences -- fueled by another good innovation, bringing three players up instead of just one at a time" (GOLF.com 6/30).

AVOIDING THE OBVIOUS? GOLF DIGEST's Dan Rapaport noted inside Pumpkin Ridges gates, and outside the media center, there has been "hardly any talk of the Twin Towers, Mohammed bin Salman, Jamal Khashoggi, Fallon Smart." No one is "discussing sharia laws treatment of Christians or homosexuals or women." The players "have been clear in their justification for being here: Im here to play golf and entertain the fans." Rapaport estimated "somewhere in the 3,000 range" for attendance on Thursday. But the fans on-site "wanted to watch the golf, and they wanted to be entertained" (GOLFDIGEST.com, 6/30).

FEELING THE VIBE: In Portland, Mitchell Forde notes those in attendance Thursday were "greeted by a scene that more closely represented a music festival than a country club, engineered to appeal to an audience beyond typical golf fans." A sprawling fan village "contained myriad Instagrammable decorations and Tik Tok-able interactive activities." Performers "rode around the area on oversized bikes or handless hoverboards." Food trucks provided a "wide range of concessions, while vendors sold beers for $5 apiece (a drastic departure from the PGA Championship, which somewhat infamously charged $18 per Michelob Ultra)." The "laid-back atmosphere inside the Pumpkin Ridge gates did not reveal so much as a hint of the criticism that has followed the tour" (Portland OREGONIAN, 7/1).

TENSION BELOW THE SURFACE: ESPNs Scott Van Pelt said "protests marked the first day" of the LIV Golf tournament in Portland. The "SportsCenter"broadcast then aired highlights of the first round of the event (ESPN, 6/30). ESPNs John Barr said ESPNs Mark Schlabach, who is on-site at the tournament, "described a fairly relaxed atmosphere within the tournament bubble which stands in stark contrast to everything going on around it." Schlabach noted "its been tense at times" in the players' press conferences, "more tense with Brooks Koepka probably than the others." But Schlabach added the "players seemed to be well-trained" when answering questions during their press conferences ("SportsCenter," ESPN, 6/30).

TALK OF THE TOWN: SBJ's "Strictly Business" Twitter Spaces talked all things LIV Golf on Thursday. SBJ's Josh Carpenter and David Rumsey were joined by The Fried Egg's Brendan Porath and Morning Read's Bob Harig, who is on the ground in Portland this week.

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LIV Golf's first US event shows signs of longevity, flexibility with players - Sports Business Journal

The key to a long, happy retirement is not just having a flush portfolio or moving to a low-tax state with 300-plus days of sunshine. Its having the good health to enjoy your golden years.

And thats more than clich. Edward Jones surveyed 11,000 adults and found that 69% wanted to live to age 100. However, some didnt want such longevity if they were in terrible health (32%), if they became a burden on their families (29%), if they had serious cognitive loss (20%), and if they no longer had purpose in life (14%).

Many people assume that their chances of a long, healthy life is largely out of their hands, controlled by the genes they inherited. Its not that simple.

While scientists previously believed that genetics accounted for roughly 25% of lifespan, new research has put that number under 10%. Genetics still matters. Whether or not you dodge a particular affliction may be determined by your genes. And for extremely long-lived peoplethose who live beyond perhaps age 105genes are still thought to pay a huge role.

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Barrons brings retirement planning and advice to you in a weekly wrap-up of our articles about preparing for life after work.

For most of us, however, whether we get 75 or 85 or 95 healthy years is affected more by lifestyle choices than by genes. Getting regular exercise and enough sleep, eating nutritious, healthy foods, staying resilient and connected with other humansthese are the habits that produce continuing good health, long lifespans and enjoyable, productive retirements. They will also lower your healthcare costs and reduce your odds of developing dementiatwo of the biggest worries for retirees.

Genetics are the gun and lifestyle pulls the trigger, says Dr. David Fein, medical director of the Princeton Longevity Center in New Jersey.

Barrons recently talked to longevity experts, geriatric doctors, and read the latest research to come up with some concrete steps for improving your odds of a long, healthy life. Some of it is age-old advice. But research has also upended some of the conventional wisdom in recent years. For example, doctors used to think that moderate alcohol consumption was good for you; new research shows otherwise.

Here are six things you can do to improve your chances for having the good health to enjoy your retirement.

Exercise isnt a particularly efficient way of losing weight. But it is great at just about everything else when it comes to improving your health.

Want to lower your blood pressure or your blood sugar levels? Want to sleep better? Want to improve your brain function and memory? Want to lift your spirits? All these things are important for our health, and over recent years, theres been much research showing how exercise helps in all.

Exercise doesnt necessarily mean going to the gym. Brisk daily walks around the neighborhood will give you similar benefits. Nor does exercise all have to be done in one continuous session. Little five- or 10-minute bursts of activity throughout the day could be even better for you than a single session.

Its very hard to make up for 47 hours of being sedentary with one hour of intensive exercise, says Dr. Fein. Chairs kill more people than anything else.

Especially as you get older, be sure to include resistance training or other weight-bearing exercises to strengthen your bones and retain muscle mass. Biking or swimming are great for your cardiovascular system but they wont protect you from osteoporosis. If youre not lifting weights, try a few minutes of jumping ropes to build stronger bones.

Can there be too much of a good thing when it comes to exercise? Some research has found that extreme exercise actually hurts your health. An in-depth study in 2018 found otherwise. It studied 122,000 patients and measured their fitness not on how much they said they exercised, but how they performed on a treadmill test. It found the extremely fit had the lowest mortality levels.

But the debate over how much exercise is too much is beside the point. The big difference in health isnt between those in good shape and those in extremely good shape. Its between those who exercise and those who dont.

All sorts of good things happen as you sleep. Cells renew themselves. Your body produces hormones, which helps restore the body and reset many of its functions. Not getting enough sleep hurts your immune function. Scientists have found that people who dont sleep enough are more likely to eventually develop dementia.

How much sleep is enough sleep? The rough rule is between six to eight hours a night for adults. But different people may have different patterns and still get enough sleep. Some people may wake up in the middle of the night, be up for an hour or two, and go back to sleep for a few more hours. Others may take a nap in the middle of the day.

What is the best pattern for you? We dont know, says Daniel Belsky, an assistant professor of epidemiology at Columbia Universitys Mailman School of Public Health, who says there hasnt been much high-quality research on the subject. What pattern is optimal for a person may depend on the life they lead.

Dr. Belsky says there has been good research on shift workers who work at night while others are sleeping, and they pay a health priceparticularly if their sleep times keep changing.

Other Americans have trouble sleeping, no matter what time it is. If that applies to you, doctors advise you to improve your sleep hygiene. Go to bed at the same time each night. Make sure your bedroom is dark and at a comfortable temperature. And dont keep checking your smartphone throughout the night.

For years, many doctors advised their patients that moderate drinking, particularly red wine, was good for them. After all, research had shown that moderate drinkers lived longer than both heavy drinkers and nondrinkers.

But new research has changed the conventional wisdom on the subject.

It finds the reason moderate drinkers had better health wasnt the alcohol; it is believed to stem from favorable lifestyle, socioeconomic, and behavioral factors.

Drinking increases your risks for heart disease, high blood pressure, diabetes and certain cancers. The risks appear minimal for light drinkers but increase with higher drinking levels.

Bottom line: Nobody should start drinking because they think its good for their health, says geriatrician Alicia Ines Arbaje, an associate professor at the Johns Hopkins University School of Medicine. Alcohol is directly toxic to the body. There is no amount that is beneficial.

Obesity is tied to a multitude of illnesses, including higher rates of diabetes, heart disease and many cancers. Obese people have been hit harder by the Covid-19 pandemic.

But it doesnt necessarily follow that going on a strict diet to shave off some pounds is good for you. Losing weight isnt that hard. But keeping weight off is quite hard, and yo-yoing up and down doesnt do your body any good.

Whats more, all fat isnt created equal. The subcutaneous fat that sits on our hips may be unsightly, but it doesnt appear to have big effects on our health. The nasty stuff is the visceral fat that surrounds our organs. It changes the hormones produced by the body, and is linked to diabetes, heart disease, certain cancers and Alzheimers disease.

The only way of knowing for sure how much visceral fat you have is some sort of body scan, which is expensive and not recommended by most health experts for the general population.

People with bigger waists or apple-shaped bodies tend to have more visceral fat. But even there it gets tricky since different ethnic groups, notably people of Asian heritage, have a tendency to carry more visceral fat.

Morgan Levine is an assistant professor at the Yale School of Medicine who studies aging and wrote the book True Age. Instead of focusing on your weight, she says people should exercise regularly and eat a healthy diet. The good news is that exercise does reduce visceral fat.

Weight is such a bad proxy or measure for what is contributing to health, Dr. Levine says. Its so much more complex than how heavy you are.

Further complicating things, while weight loss may be desirable for the general population, it often isnt for seniors because it can cause loss of muscle and can contribute to osteoporosis. Geriatrician Deborah Kado, who has done extensive research on bone health and is co-director of the Stanford Longevity Center in California, doesnt usually advise her older patients to lose weight.

I tell them its insurance if you go into the hospital, she says. There is a lot of data that indicates that weight loss, whether intentional or unintentional, has been associated with adverse health outcomes rather than health benefits.

Nutrition is one of the trickier areas to research. Its hard to know exactly what research subjects actually eat. And it can take years for health effects to emerge. Nonetheless, scientists are seeing eating patterns that contribute to longevity.

A study found that even 60-year-olds could add an average eight or nine years to their lives by abandoning a Western diet. The biggest gains came from eating more legumes, whole grains and nuts, and eating less red meat and processed meat. Eating more fish was also a plus. The effects of eggs, poultry and oil were less clear. If it sounds a lot like the Mediterranean diet, it is. But its emphasis on vegetables, legumes and whole grains also bears similarities to how people eat in other parts of the world known for longevity.

Americans eat too much protein, says Yales Dr. Levine. She says protein contributes to overly high levels of the human growth hormone, which is linked to certain cancers and appears to increase aging.

But once again, the recommendation changes when it comes to seniors. Older people dont process protein as well, and need more of it in their diet to maintain muscle mass, research has found.

Live long enough, and bad things are likely to happen to you or the people around you. How you deal with them is key. People who have a positive mind-set on things they cant control tend to have much better outcomes, says Dr. Kado, the Stanford geriatrician. She says it is almost the most important factor in how her patients fare.

People are social creatures. And we tend to be more resilient when we have strong social connections. This can come through our family, our friends, our church, or even our retirement community. There has been research showing that maintaining social connections is good for brain health. So go for a walk with a friend and eat an apple afterward.

When it comes to longevity, these are all steps in the right direction. Saving for that longer life, and retirement, is another story.

Write to retirement@barrons.com

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Here's How to Maximize Your Healthy Years in Retirement. Eat Right and Exercise. - Barron's

Story at a glance

Busy Americans may not have time during the week to fit in the American Heart Associations recommended 150 minutes of moderate intensity exercise. But new research from nearly 351,000 adults shows the benefits of exercising only on the weekends are comparable to those seen among more regular exercisers.

Writing in JAMA Internal Medicine, researchers explained how they assessed data from the National Health Interview Survey which took place between 1997 and 2013. Authors classified those who completed all their recommended weekly exercise in one or two sessions as weekend warriors and those who spread out sessions as regularly active.

Participants were followed for a median of 10.4 years and within that time frame, 4,130 people died of cardiovascular disease and 6,034 from cancer.

Similar all-cause mortality hazard ratios were reported for weekend warriors and regular exercisers when compared with inactive participants. Cause-specific mortality hazard ratios were also similar between the two active groups.

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According to the authors, findings reinforce the importance of reaching the recommended levels of physical activity for health.

They continued, for people with fewer opportunities for daily or regular physical activity during their work week, these findings are important.

Exercise can help prevent onset of several non-communicable diseases in addition to combating obesity and weight gain. Currently, 42 percent of the United States population is obese and 9.2 percent are classified as severely obese.

The papers findings underscore the importance of meeting total exercise time thresholds each week, as opposed to how often one exercises or at what time of day.

The self-reported nature of questionnaires marks a limitation to this study, as participant bias may have impacted results. However, a large sample size and the long duration of the study bolsters the conclusions reliability.

Published on Jul. 07, 2022

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Exercising only on the weekend is still effective, study finds - The Hill

Generational owners of multifamily properties turn to us because they will get more personalized service than they would from the bigger players, who cannot provide the same high level of attention we can.

ROSELAND, N.J. (PRWEB) July 07, 2022

Kriegman & Smith, Inc., a multifamily real estate investment and property management firm, is marking its 50th anniversary. This milestone underscores not only the longevity of the business, but just as important, the number of properties that have remained under management with the company over multiple generations, throughout New Jersey and Pennsylvania.

Founded by Michael Smith and Sam Kriegman in 1972, the firm grew from one desk and two northern New Jersey communities comprising 240 units to a portfolio of 6,000 apartment and townhouse units in two states. The company owns and manages garden apartments, mid-rises, luxury high rises, and townhouse-style duplex apartments across a range of rental rates. Kriegman & Smiths portfolio also includes properties it manages for third-party investors, including three non-profit affordable housing properties.

Today, the company is run by second-generation Co-Owner Jeffrey Smith and Co-Owner Adam Kaplan, who are committed to the firms founding principles: a dedication to maintaining high-quality luxury and affordable workforce housing available for renters for those just starting out in life to residents who remain tenants for decades.

Kriegman & Smiths history has not only been one of growth through acquisition and third-party partnerships, but also one that demonstrates longevity and stability among its properties, as well as employees. Weve always been committed to long-term goals and relationships, Kaplan said.

A history of longstanding relationships

One reason why we have maintained so many properties and retained so many employees across generations is that our core values have never wavered and are still our guiding principles 50 years later, said Smith. We treat each building as if it were our own. Thats never changed.

To that end, we are committed to delivering well-maintained properties that have benefited from strong investment in their upkeep and upgrades, with high-quality components meant to serve multiple generations of owners, managers and tenants, Smith noted. The company has also invested substantially in its own infrastructure to meet the challenging rental environment.

Were a small company committed to running our buildings with the same values our founders relied upon, but much like the large national firms, we have invested in the latest, most sophisticated property management technology to optimize operating procedures, said Kaplan, referring to its back-end integration with the firms website and digital tools for leasing agents, regional managers, resident managers and maintenance teams.

An owners perspective in third-party property management Smith attributes some of the companys success and longevity to the owners approach to property management, which has fueled its growth as a niche management operator for investor/owners and its expansion of services for those clients.

Generational owners of multifamily properties turn to us because they will get more personalized service than they would from the bigger players, who cannot provide the same high level of attention we can. These clients know that, as a third-generation, family-owned and -operated company, we appreciate the owners perspective and understand the importance of relationships and responsiveness across stakeholdersfrom the owners themselves to their leasing teams, superintendents and of course, residents, said Smith.

Property owners speak and work directly with Smith and Kaplan, without having to go through gatekeepers and a corporate chain of command and appreciate the flexibility available to them to meet their varied needs, instead of cookie cutter services.

Lisa DAllesandro, a managing member at Candal Properties LLC, has been a client of Kriegman & Smith since 2015, which manages their Hackensack, NJ, luxury high rise building with 267 units, concurs, Like Kriegman & Smith, we are a family-owned business, too, and appreciate the hands-on service and accessibility of the firms management team. There are some formulas you just dont change, and like us, they treat their staff like family.

Longstanding management of senior residences Kriegman & Smith also operates multiple communities for low-income seniors, some for 35 years or longer.

We are among a small group of property management companies that manage both market rate and subsidized properties, said Kaplan. Were very proud of this and value those properties and our relationships with them.

Those relationships have extended to both the management team and company employees getting personally involved, from showing up to flip burgers at barbeques to setting up and coordinating a COVID-19 vaccination drive at three sites through a partnership with Walgreens. For example, in January 2021, when vaccines were not yet widely available and appointments were challenging to access, the Kriegman & Smith team was able to get residents vaccinated and volunteered on site at all three residences in Union and Nutley as part of the companys commitment to community service.

Kriegman & Smith celebrated its 50th anniversary officially with an employee event on June 23. More information about the company is at http://www.kriegmanandsmith.com. ###

Photo Caption: Kriegman & Smith, Inc. on June 23, 2022, held a party for employees at Park Ave. Club in Florham Park. More than 150 employees and family members attended, where they celebrated 2020 and 2021 missed holiday parties and, of course, the Companys 50th Anniversary. A long list of more than 25 employees that have been with the firm since the last millennium were recognized.

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Kriegman & Smith, Inc. Celebrates 50 Years of Multifamily Investment and Property Management Business Across Generations - PR Web

Aaron Rodgers is one of the best quarterbacks in the NFL, and sometimes his reputation and demeanor equate him to LeBron James of the Lakers.

On more than one occasion, the Packers quarterback has shown how prolific he is. He is the NFLs reigning back-to-back MVP, and its hard to say that anyone has played better than him in the last two years.

Rodgers has had his ups and downs with the Packers organization, but overall, hes shown that hes an indispensable part of the franchises history.

Theres a subtle art about the way Aaron Rodgers plays. Hes aggressive without turning the ball over, as good in the pocket as he is out of it, and he can make throws no other player in the league can. For lack of better words, hes a magician.

Also Read: Anthony Edwards is taking your job Tom Brady: NFL and NBA fans go crazy after a viral Tweet of the Timberwolves star catches Bucs QBs attention

We all know about LeBrons dominance in the NBA. Hes a four-time NBA champion, and hes been to the Finals 10 times in his career, a high among all active players.

LeBron has never had a truly bad season. Even dating back to his rookie year, youd be hard-pressed to find a season when LeBron wasnt unequivocally the best player on his team, and perhaps even the league.

Michael Smith talked about how Rodgers once said that down year for him is a career year for most quarterbacks, and after hearing that statement, he immediately knew which NBA star to compare the Packers quarterback to.

Smith noted that even though other players like Giannis or Steph may try to take the throne by winning MVPs or titles, at the end of the day, LeBron is the most dominant.

Similarly, Rodgers holds that edge in the NFL. He felt that Brady had fallen off his peak and that the Green Bay star still reigns supreme over his biggest challenger in Patrick Mahomes.

Its a valid comparison to make. Rodgers has been the most consistently good quarterback in the league, especially in recent times. The only thing thats eluded him is a Super Bowl win.

Rodgers has also aged like LeBron. Hes 38 years old, coming off back-to-back MVPs. Last year, LeBron played at an MVP level despite being 36-37 years old. Time doesnt affect these two beasts.

Also Read: LeBron James is my favorite basketball player, for sure: Lamar Jackson snubbed Michael Jordan as he revealed his favorite NBA player is the Lakers star

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"Aaron Rodgers is to the NFL what LeBron James is to the NBA": Michael Smith detailed how the Packers QB's... - The Sportsrush

Enlarge / System76 Lemur Pro.

System76 has refreshed its thin-and-light take on Linux laptops, the companyannounced Tuesday, as spotted by Tom's Hardware. The revamped 14-inch Lemur Pro, like its predecessors, prioritizes a longer battery life, with the latest model claiming up to 14 hours of use.

[Update July 8, 2022, 9:28 a.m. ET: A spokesperson for System76 told Ars Technica that the battery life claim was determined after testing under four conditions:

The Lemur Pro has a proven reputation for solid battery life. In our Lemur Pro review in 2020, when the machine was offered with an Intel Core i7-10510U, it lasted at least one hour longer than any other laptop we reviewed around that time when playing BBC's "10 Hours of Relaxing Oceanscapes" at 1080p resolution and max brightness.

It was clear that System76 had fine-tuned the machine more for longevity between charges than productivity performance.

The 2022 Lemur Pro is configurable with up to an i7-1255U, part of Intel's U-series aimed at machines more concerned about power efficiency. The i7-1255U specificallyhas two high-performance P-cores (1.74.7 GHz), eight efficient E-cores (1.23.5 GHz), 12 threads, and 12MB of cache. For a quick comparison, System76's larger (15- or 17-inch) Gazelle laptop, which includes an Nvidia RTX 3060 laptop graphics card, has an i7-1200H with six P-cores (2.3-4.7 GHz), eight E-cores (1.7-3.5 GHz), 20 threads, and 24MB of cache.

But the Lemur Pro is more about battery longevity and portability, as you can tell from its 2.54-lb weight and 0.65-inch thickness.

It's also configurable with up to 40GB of dual-channel DDR4-3200 RAM (8GB + 32GB) and 4TB of storage available over two M.2 slots (up to one PCIe 4.0 and one PCIe 3.0).

Other specs include a 1920 x 1080 display, a 1080p webcam, two USB-A ports, one Thunderbolt 4 port, and a Micro SD card reader, plus the option to runUbuntu 22.04 LTS orPop!_OS 22.04 LTS.

The laptop's firmwareuses the Coreboot open source firmware platform, and itsembedded controller firmware is open source, too.

System76's Lemur Pro starts at $1,150.

See the article here:
System76s lightweight Linux laptop refreshed with focus on battery life - Ars Technica

Positive social interactions among older adults can be tied to their sense of purpose, especially among those who are retired.

For everyone, but specifically for our retired older adults, the people in their lives really matter, the studys leader Gabrielle Pfund said in a release.

For the small study published in the American Journal of Geriatric Psychiatry, researchers worked with close to 100 adults with an average age of around 71.

Participants were asked three times each day to rate their social interactions. Each evening they were asked to rate their overall interactions based on the question: How much do you think your life had a purpose today?

Researchers found that the more positive social interactions a person had during the day, the more purposeful they felt during the evening questionnaire.

Pfund said while most previous research was focused on the big picture her teams findingssuggest ones sense of purposefulness can vary daily.

Most research on sense of purpose is focused on big-picture orientation of someone being purposeful versus someone being not purposeful, Pfund said.

We found purpose can change from day to day, Pfund continued. Everyone was experiencing fluctuations relative to their own averages.

The authors noted the findings might be influenced by a couple of limitations, including that most of the study participants were healthy.

Yet the authors pointed to previous research that shows the positive health benefits of social interactions, such as lower rates of Alzheimers disease and heart problems.

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By enhancing sense of purpose, older adults will then be more likely to experience the valuable cognitive and physical healthy aging benefits that come with it, the authors wrote.

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Published on Jul. 07, 2022

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Positive interactions linked to sense of purpose, study finds - The Hill

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An American study hopes to determine whether genetic or environmental factors are more important in the durability and longevity of Standardbred racehorse careers.

The project is a collaboration between the US Trotting Association and Dr Doug Antczaks laboratory at Cornell Universitys Baker Institute for Animal Health.

The project involves up to 300 horses, including younger racehorses that will serve as controls, focusing on Standardbreds with long and successful careers the so-called iron horses of harness racing.

Other veterinary scientists from Cornell, the universities of Illinois, Kentucky, and Minnesota, and the Racing Medication and Testing Consortium are also participating.

The study team includes geneticists from the Horse Genome Project, veterinary clinical specialists, epidemiologists, and computational biologists.

The aim of the project is to determine whether genetic or environmental factors are more important in durability and longevity of racing careers of Standardbred horses, Antczak said.

The question is highly relevant because the answer may help reduce racing-associated injuries and contribute to equine welfare in the harness racing industry. This would be good for the horse, good for the owners, and good for the harness racing industry.

The first step in this study was to develop a list of horses that have raced for a minimum of five years. The US Trotting Association database was instrumental in this phase of the project, revealing more than 6000 horses that achieved this. About 75 percent of the horses are pacers, and the remainder, trotters.

As expected, most were geldings. Successful racing stallions and mares are usually retired early from competition for breeding.

The horses were then ranked by earnings or number of race starts, and separated by gait.

In the northern spring, the researchers began contacting trainers and owners to enrol selected horses in the study, with the only sample required for the study being a small quantity of blood for DNA analysis.

The selected durable horses will be compared with an appropriate control group using molecular-based testing that can identify genetic differences among individuals at 640,000 locations spread across the DNA sequence of the horse genome. Computer programs are used to analyze the large data sets produced in projects of this type.

The data will be evaluated in association with race records and other information about the horses contained in US Trotting Association databases.

Subsequently, full DNA sequences will be obtained from a small number of Standardbreds with long and successful careers in a bid to pinpoint regions of the genome responsible for durability traits.

The work is supported by a research grant from the Harry M. Zweig Memorial Fund for Equine Research at Cornell University.

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Study probes reasons for success among the "iron horses" of harness racing - Horsetalk.co.nz - Horsetalk