Newly Discovered Gene Could Be the Secret to Longevity SciTechDaily
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Newly Discovered Gene Could Be the Secret to Longevity - SciTechDaily
Poverty and longevity: mutually exclusive what if we thought more about the link between housing and health? Real Change News
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Poverty and longevity: mutually exclusive what if we thought more about the link between housing and health? - Real Change News
People in Blue Zones swear by beans for healthy aging here are 3 longevity-boosting bean dishes from a recipe developer Business Insider
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People in Blue Zones swear by beans for healthy aging here are 3 longevity-boosting bean dishes from a recipe developer - Business Insider
The Key to Healthy Aging and Longevity Daily Item
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The Key to Healthy Aging and Longevity - Daily Item
Associations Between Professional Sports and Longevity Lifespan.io News
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Associations Between Professional Sports and Longevity - Lifespan.io News
Samuel L. Jackson Reflects on His Longevity in Hollywood: 'I've Been Kind of Fortunate' (Exclusive) PEOPLE
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Samuel L. Jackson Reflects on His Longevity in Hollywood: 'I've Been Kind of Fortunate' (Exclusive) - PEOPLE
The 100-year life is here. We're not ready.
The New Map of Life calls on us to shift from a deficit mindset that laments the losses now associated with agingwhether to health, mobility, financial security, independence, or social engagementand to assess the economic and social contributions of older adults so that we can get a true accounting of net costs and benefits of our current population structure.
We can invest in future centenarians by optimizing each stage of life, so that benefits can compound for decades, while allowing for more time to recover from disadvantages and setbacks.The pivotal years between birth and kindergarten are the optimal time for children to acquire many of the cognitive, emotional, and social skills needed for a healthy, happy, and active life.
Todays 5-year-olds will benefit from an astonishing array of medical advances and emerging technologies that will make their experience of aging far different from that of todays older adults. And while there is no way to stop the process of aging, the emerging field of geroscience has the potential to transform how we age, by seeking to identifyand reprogramthe genetic, molecular, and cellular mechanisms that make age the dominant risk factor for certain diseases and degenerative conditions.
While the conventional life course is a one-way road through prescripted stages, The New Map of Life offers multiple routes connecting the roles, opportunities, and obligations that 100-year lives will bring and its expected that people will reset the GPS often. There are intersections, cloverleafs, curves, on-ramps, and off-ramps to and from the decades of life dedicated to paid work, providing more opportunities for informal learning and lifelong learning, and for intergenerational partnerships that improve the flow of knowledge, support, and care in all directions.
Over the course of 100-year lives, we can expect to work 60 years or more. But we wont work as we do now, cramming 40-hour weeks into lives impossibly packed from morning until night with parenting, family, caregiving, schooling and other obligations. Workers seek flexibility, whether that means working from home at times, or having flexible routes in and out of the workplace, including paid and unpaid intervals for caregiving, health needs, lifelong learning, and other transitions to be expected over century-long lives.
The impacts of the physical environment begin before birth, with advantages and disadvantages accumulating over the entire course of life, determining how likely an individual is to be physically active, whether they are isolated or socially engaged, and how likely they are to develop obesity, respiratory, cardiovascular, or neurodegenerative disease. We must start now to design and build neighborhoods that are longevity-ready, and to assess potential investments in infrastructure through the lens of longevity.
The speed, strength, and zest for discovery common in younger people, combined with the emotional intelligence and wisdom prevalent among older people, create possibilities for families, communities, and workplaces that havent existed before. Rather than dwelling so anxiously on the costs incurred by an aging society, we can measure and reap the remarkable dividends of a society that is, in fact, age-diverse.
Meeting the challenges of longevity is not the sole responsibility of government, employers, healthcare providers, or insurance companies; it is an all-hands, all-sector undertaking, requiring the best ideas from the private sector, government, medicine, academia, and philanthropy. It is not enough to reimagine or rethink society to become longevity-ready; we must build it, and fast. The policies and investments we undertake today will determine how the current young become the future oldand whether we make the most of the 30 extra years of life that have been handed to us.
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The New Map of Life - Stanford Center on Longevity
If longevity runs in your family, you have a better chance of living longer. But genetics is only part of the equation: the lifestyle choices you make play a big role in living longer, staying healthy, and being able to continue doing the things you love.
Longevity simply refers to long life. In the U.S., life expectancy has increased dramatically since 1900, when the average lifespan was 47 years. Today, people born in 2022 can expect to live 77.5 years.
Experts estimate that about 25% of the variation in human life span is determined by genetics. But the rest can be attributed in large part to how we take care of our bodies.
And that's important because there is more to longevity than duration. Most us don't want to just live longer we want to live longer while enjoying a good quality of life.
There are simple things you can do to be your healthiest, most active, most productive self while living longer. The keys to perhaps living to age 100 or more are a healthy diet, regular physical activity, and good lifestyle choices.
What you eat has a direct impact on the cells in your body which in turn has an impact on longevity.
A healthy diet provides cells with vital sources of energy and keeps them stable and working as they should. Healthy foods support your immune cells, which defend against infections and other health threats, protect other cells from damage, and help the body repair or replace damaged cells.
A diet high in sugar, unhealthy fats, and processed foods, on the other hand, can leave cells throughout the body more vulnerable to damage and poor function. This can lead to an increased risk of infection, cancer, inflammation, and chronic diseases such as diabetes, cardiovascular problems, and obesity.
An excellent diet for promoting longevity is a plant-based diet. A study published in JAMA Network Open found that women who most closely adhered to the plant-based Mediterranean diet, which emphasizes vegetables (excluding potatoes), fruits, nuts, whole grains, legumes, and fish, and minimizes red and processed meat, were 23% less likely to die from any cause than women who did not closely adhere to this dietary pattern.
A plant-based diet involves eating lots of fruits and vegetables, beans, nuts and seeds, and whole grains instead of processed foods. Foods from plants are high in antioxidants such as beta carotene, lycopene, and vitamins A, C, and E, which protect cells from damage.
Following a plant-based diet doesn't mean you need to become a vegetarian, or never have meat or a dessert. It simply means that most of the foods you eat should be minimally processed and come from plants.
A multitude of studies show that physical activity contributes to greater longevity, due to the many positive effects it has on the body. These effects include stronger heart and lung function, improved health of blood vessels, stronger muscles, better balance, and a healthier weight.
Being more active may lower your risk of heart attack, stroke, falling, and diabetes, among other benefits. Together, these benefits contribute to a longer lifespan. Physical activity can also improve your mood and help you sleep better.
How much physical activity do you need to help you stay healthy and live longer? The 2018 Physical Activity Guidelines for Americans recommend that adults get at least
Moderate physical activity includes walking, weight lifting, and lower-intensity exercises. Vigorous exercise includes running, bicycling, and swimming. Even household tasks like cleaning and gardening count as exercise. So does lifting small hand weights or doing leg lifts while watching TV. The guidelines also recommend muscle-strengthening activities on two or more days per week.
The bottom line is that moving more can extend your life.
In addition to healthy eating and being more active, the following lifestyle choices can have an enormous impact on longevity and quality of life.
Adopting and maintaining healthy behaviors can go a long way toward living a long, healthy life.
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Longevity: Lifestyle strategies for living a healthy, long life
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Halia Therapeutics' CEO, Dr. David J. Bearss, to Present Groundbreaking Research on Chronic Inflammation and Aging at the 3rd Edition Global Longevity...
Humans have searched for the secret to immortality for thousands of years. For some people today, that quest includes things like sleeping in a hyperbaric chamber, experimenting with cryotherapy or blasting oneself with infrared light.
Most aging experts are skeptical that these actions will meaningfully extend the upper limits of the human life span. What they do believe is that by practicing a few simple behaviors, many people can live healthier for longer, reaching 80, 90 and even 100 in good physical and mental shape. The interventions just arent as exotic as transfusing yourself with a young persons blood.
People are looking for the magic pill, said Dr. Luigi Ferrucci, the scientific director of the National Institute on Aging, and the magic pill is already here.
Below are seven tips from geriatricians on how to add more good years to your life.
The number one thing experts recommended was to keep your body active. Thats because study after study has shown that exercise reduces the risk of premature death.
Physical activity keeps the heart and circulatory system healthy and provides protection against numerous chronic diseases that affect the body and mind. It also strengthens muscles, which can reduce older peoples risk of falls.
If we spend some of our adult years building up our muscle mass, our strength, our balance, our cardiovascular endurance, then as the body ages, youre starting from a stronger place for whatever is to come, said Dr. Anna Chang, a professor of medicine specializing in geriatrics at the University of California, San Francisco.
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The 7 Keys to Living Longer and Healthier - The New York Times
I used to flinch at the topic of aging. Is there anything we can do about the inevitable?
But recently I've been digging into a new wave of longevity research that is making it an exciting time to be an aging human which is all of us.
It turns out, we all age at varying rates. Super-agers may have great genes, but research shows our habits and routines everything from what we eat and how we move our bodies to who we spend our time with matter a lot, when it comes to aging well.
Now, the next frontier is to target the basic biology of aging and come up with new interventions to slow it down.
Many scientists are optimistic that we're on the cusp of breakthroughs. Not only to help us live longer, but more importantly to extend the number of years we live with good health.
This is the goal of researchers at the Human Longevity Lab at the Northwestern University Feinberg School of Medicine. They're recruiting study participants so they can test what kinds of interventions may slow the rate of aging. To that end, I decided to roll up my sleeve for science.
When I arrived, the first step was a quick blood draw. The Potocsnak Longevity Institute is housed on the light-filled 21st floor of Northwestern Memorial Hospital, overlooking Lake Michigan. It felt more like a spa than a doctor's office. I didn't anticipate the vast range of data and insights scientists could glean from a battery of tests.
Over a four-hour period, they performed more than two dozen assessments. At first it felt a bit like an annual physical. They checked my blood pressure, weight, glucose and cholesterol.
NPR's Allison Aubrey has her body composition measured inside a BodPod. Several other tests performed at the longevity lab led by Dr. Douglas Vaughan are used to estimate biological age. Jane Greenhalgh/NPR hide caption
NPR's Allison Aubrey has her body composition measured inside a BodPod. Several other tests performed at the longevity lab led by Dr. Douglas Vaughan are used to estimate biological age.
But then, the tests got a lot more interesting. Inside a small exam room, a medical assistant opened the hinge of a BodPod, a capsule that looks like a submersible. The machine assessed my body composition, determining the ratio of fatty mass to lean mass, which includes muscle. Strength is a key marker of healthy aging, helping us fend off frailty and falls.
Next, I was asked to sniff and identify a range of distinct smells from leather to chocolate to test olfactory function. The loss of smell can be an early sign of disease and cognitive decline. They scanned my retina and took digital images of the inside of my eyes, which can also help detect disease. And I took a memory and cognitive function test, called MOCA. Thankfully, all was healthy.
Then I went through a slew of cardiovascular health tests. They measured my endothelial function, which keeps blood flowing smoothly through the body. They looked at my heart rate variability and pulse-wave velocity, which is an indicator of stiffness of the arteries. I had electrodes placed onto my chest for an electrocardiogram.
Midway through I was feeling a bit nervous, and my mind raced to what ifs.
Of all the tests they performed, the most intriguing is the GrimAge test. This test predicts biological age. It's gauging whether your DNA age is younger, or older, than your actual age, known as chronological age. Conjure images of the Grim Reaper? Yep, that's the idea: The test can estimate how quickly, or slowly, you're aging.
To figure this out, researchers use a technique based on DNA methylation, which is a measure of modifications in our DNA. Basically, as we age, compounds called methyl groups attach to some of our DNA molecules, which can turn genes on or off. Researchers have shown that the higher the proportion of methylated DNA in certain locations, the more accelerated a person's biological age. Published research suggests this is a reliable way to predict life span and health span.
No one wants to find out they're aging faster than their peers, right? But here's the exciting part. Our biological age may be malleable. The hope is that we can slow down our rate of aging by making changes to lifestyle. Down the line, there may be anti-aging pills or other interventions.
Dr. Douglas Vaughan and Dr. John Wilkins of the Northwestern University Feinberg School of Medicine and the Potocsnak Longevity Institute. Allison Aubrey/NPR hide caption
Dr. Douglas Vaughan and Dr. John Wilkins of the Northwestern University Feinberg School of Medicine and the Potocsnak Longevity Institute.
For researchers, the GrimAge test isn't just a way to estimate DNA age. It's a tool to study whether interventions can alter it.
"That's the big ray of optimism that comes through all of this the possibility that we can slow down aging and extend the health span of people," says Dr. Douglas Vaughan, director of the Longevity Institute. Health span is the number of years we live with good health. "It can be changed very rapidly in experimental models and probably in people, too," he says.
For example, smoking has a very strong effect on methylation. "Tens of thousands of locations gain methylation when you smoke," explains researcher Steve Horvath, who developed the epigenetic clock used as part of the GrimAge test. People with obesity also exhibit higher methylation at certain locations. "Conversely, if you eat vegetables, if you are lean, if you exercise, that slows methylation age," he explains.
Now, of course, it's long been known that smoking and eating poorly are bad for you. But researchers can now test specific interventions to see if it's possible to move the needle.
Vaughan's deep interest in aging took off when he identified a distinct genetic variant in an Amish community in Indiana. People who have the variant are protected from diabetes and have healthier cardiovascular systems compared to people who don't. In the laboratory, when Vaughan engineered mice to have only a 50% level of a protein associated with this mutation, their life spans increased by nearly fourfold. "This was a eureka moment," he says.
He tells his current medical students that in their careers they will prescribe interventions to slow down biological aging in their patients.
"I don't know exactly what that's going to be. It might be a drug. It might be a lifestyle intervention, for all I know it might be gene editing," Vaughan says. "But there are going to be ways that we are going to slow down this process and give people a longer health span."
People who live in the upscale Chicago neighborhood where the Human Longevity Lab is located can expect to live a much longer, healthier life compared to people who live just a few miles away. Vaughan wants to help close this gap.
"I'm worried about the poor soul in south Chicago who has a life expectancy of 55, compared to 92 in the neighborhood where we're standing right now," he says. A stunning difference of more than 30 years. (You can check out life expectancy in your ZIP code here.)
A lot of factors play into this life expectancy gap including poverty, housing, stress and crime, which can all work against health span.
Vaughan and his collaborators are enrolling people from a wide range of ages, ethnic groups, neighborhoods and socioeconomic status to see what works to slow biological aging for everybody.
"There are lots of people who've been dealt a bad hand with regard to aging," Vaughan says. Their goal is to find affordable, evidence-based interventions that can benefit everyone, regardless of socioeconomic status.
For example, there's interest in studying stress, which Vaughan says could be "part of the reason for the discrepancy in the life expectancy in different neighborhoods of Chicago." To study this, he could measure people's biological age at baseline, have them try a stress-reduction program, and test again to see if their results changed.
Vaughan is also interested in studying people with chronic HIV, who tend to age at an accelerated rate. A charitable gift from a Chicago family with a shared interest helped launch the institute. Vaughan's team is considering a range of interventions to test whether they can slow down aging in this population.
"It might be weight training, it might be intermittent fasting, it might be dietary manipulations, it might be drugs that are available now that might have anti-aging effects," Vaughan explains, citing the diabetes drug metformin.
Longevity and health span research is attracting lots of funding and attention, from places like the Hevolution Foundation, which provides grants and early stage investments, and Altos Labs, a biotechnology company, founded by Dr. Rick Klausner, which is investigating ways to reprogram or rejuvenate cells.
Dozens of groups have signaled their intent to compete in the $101 million X-PRIZE global competition focused on treatments that support healthy longevity everything from new drugs or supplements, to devices, to repurposing old drugs for new uses.
"Teams have to come to the starting line and we're going to set up the frameworks by which they prove their therapeutic works," says XPRIZE's Jamie Justice, who is also a researcher at Wake Forest University School of Medicine.
Fortunately, my GrimAge score came back younger than my actual age, though I did get some surprises. I learned that my body composition isn't optimal. Turns out, I need to build more lean muscle mass, which is pretty common as we age especially for women.
With muscle mass, if you don't use it, you lose it. After the age of 30 to 35, muscle starts to slowly decline. And after age 65 or so, this loss accelerates. So it's never too soon to start building a reserve. My goal for this year is to build muscle through resistance training and an optimal diet. And also, to reduce stress.
My experience in the longevity study has motivated me to get started on a new project: How To Thrive As You Age. We'll have more stories on healthy aging interventions coming soon.
As part of this project, we hope you'll share your healthy aging tips with us. What habits or lifestyle hacks have you've adopted to thrive as you age? Please use this form to share your thoughts or email us at Thrive@npr.org.
Series editors Jane Greenhalgh and Carmel Wroth
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The keys to longevity may start in the lab. How aging science is ... - NPR
Longevity is the achievement of a long life. We may hope for longevity so that we can experience many years of quality time with loved ones or have time to explore the world. But living to a ripe old age doesnt necessarily mean healthy or happy longevity if it is burdened by disability or disease. The population of people over age 65 has grown more quickly than other age groups due to longer life spans and declining birth rates, and yet people are living more years in poor health. [1] Therefore, we will explore not just ones lifespan but healthspan, which promotes more healthy years of life.
What you do today can transform your healthspan or how you age in the future. Although starting early is ideal, its never too late to reap benefits.
Researchers from Harvard University looked at factors that might increase the chances of a longer life. [2] Using data collected from men and women from the Nurses Health Study and Health Professionals Follow-up Study who were followed for up to 34 years, researchers identified five low-risk lifestyle factors: healthy diet, regular exercise (at least 30 minutes daily of moderate to vigorous activity), healthy weight (as defined by a body mass index of 18.5-24.9), no smoking, and moderate alcohol intake (up to 1 drink daily for women, and up to 2 daily for men). Compared with those who did not incorporate any of these lifestyle factors, those with all five factors lived up to 14 years longer.
In a follow-up study, the researchers found that those factors might contribute to not just a longer but also a healthier life. [2] They saw that women at age 50 who practiced four or five of the healthy habits listed above lived about 34 more years free of diabetes, cardiovascular diseases, and cancer, compared with 24 more disease-free years in women who practiced none of these healthy habits. Men practicing four or five healthy habits at age 50 lived about 31 years free of chronic disease, compared with 24 years among men who practiced none. Men who were current heavy smokers, and men and women with obesity, had the lowest disease-free life expectancy.
Beyond the five core lifestyle habits mentioned above, a growing body of research is identifying additional factors that may be key to increasing our healthspans:
These senses can decline over time for various reasons: normal aging, which causes a gradual decrease in taste and smell; prescription drugs that reduce taste sensitivity and promote dry mouth or lack of saliva; deficiencies in micronutrients such as zinc that reduce taste; and poor dentition with tooth loss or dentures leading to chewing problems. [19] Up to 60% of adults 70 years and older may lose their sense of taste. [20] With this loss may come heavier seasoning of food with sugar and salt. [21] They may prefer softer lower-fiber foods that dont require much chewing. Poor taste and smell in the elderly is associated with lower dietary quality and poorer appetite. [22]
Food aromas are important as they trigger the release of saliva, stomach acid, and enzymes in preparation for digestion. [23] The scent of food can trigger the release of dopamine and serotonin, causing a feeling of wellbeing to encourage eating. An impaired sense of smell in older adults is also associated with less variety in food choices and poorer nutrition, but can also lead to increased food intake and weight gain in some individuals. [23]
Seasoning food more liberally with sodium-free herbs, spices, and vinegars may help to compensate for sensory deficiencies. Using foods with a savory umami quality like mushrooms, tomatoes, some cheeses, and yeast can boost richness and flavor. Another sensory aspect of food called kokumi describes a full and rich mouthfeelsuch as that experienced from a minestrone soup, an aged cheese, or a seafood stew simmering for many hours. If poor appetite from sensory loss is a problem, providing variety through different textures, smells, and colors in the meal may stimulate an increased desire to eat. [21]
Eating and food preparation are also important activities offering socialization and mental stimulation such as when learning new cooking skills. Preparing meals helps to reduce sedentariness as there are several action steps involved: selecting and purchasing, washing and chopping, and cooking the ingredients.
Japanese women and men currently live five to six years longer than Americans, so their practices are of great interest. In Japanese families, elders are highly revered and households are intergenerational. Japanese elders are generally healthier than Western elders, but is this the chicken or the egg? Does better health from good lifestyle habits allow them to stay physically active and involved in society so they remain a valuable asset and reap psychosocial benefits, or is it the culture that reveres elders so they have better mental health, less loneliness, and better healthcare so that they stay healthier longer? Japan has also largely avoided the epidemic of obesity that the U.S. is experiencing; for example, the prevalence of obesity among U.S. women is about 37% but among Japanese women is less than 5%. [24] This difference is certainly an important contributor to differences in life expectancy, but raises questions about how the Japanese have been able to control their weight. In recent years, diets in Japan have become more similar to those in the U.S. but they still eat smaller portions, more fermented foods, less sweets, and less red meat.
Identifying additional factors that improve and extend our healthspans is an active area of scientific inquiry. In the meantime, current research findings are encouraging, and underscore the importance of following healthy lifestyle habits throughout ones life course. That said, sticking to these behaviors is easier said than done, and public policies must support and promote these habits by improving the food and physical environments that surround us.
Last reviewed December 2022
The contents of this website are for educational purposes and are not intended to offer personal medical advice. You should seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The Nutrition Source does not recommend or endorse any products.
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Healthy Longevity The Nutrition Source
Conference call scheduled for Monday, June 24th at 4:30 pm ET Conference call scheduled for Monday, June 24th at 4:30 pm ET
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Beyond Air® Schedules Fiscal Year End 2024 Financial Results Conference Call and Webcast
PARIS and CAMBRIDGE, Mass., May 23, 2024 (GLOBE NEWSWIRE) -- NANOBIOTIX (Euronext: NANO –– NASDAQ: NBTX – the ‘‘Company’’), a late-clinical stage biotechnology company pioneering physics-based approaches to expand treatment possibilities for patients with cancer, announced today that Company management will participate in a fireside chat at the upcoming Jefferies Global Healthcare Conference. Please see below for details of the event.
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NANOBIOTIX to Present at the Jefferies Global Healthcare Conference
WINNIPEG, Manitoba, May 23, 2024 (GLOBE NEWSWIRE) -- Kane Biotech Inc. (TSX- V:KNE; OTCQB:KNBIF) (the “Company” or “Kane Biotech”) today announces its first quarter 2024 financial results.
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Kane Biotech Announces First Quarter 2024 Financial Results
TTX-080 plus EGFR Inhibitor Cetuximab Demonstrated Promising Evidence of Clinical Activity in Patients with Biomarker-Defined Metastatic Colorectal Cancer and Locally Advanced/Metastatic Head and Neck Squamous Cell Carcinoma
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Tizona Therapeutics Presents Phase 1b TTX-080 Clinical Data in Advanced Colorectal Cancer and Head and Neck Squamous Cell Carcinoma at ASCO 2024
WEST LAFAYETTE, Ind., May 23, 2024 (GLOBE NEWSWIRE) -- Inotiv, Inc. (Nasdaq: NOTV) (the “Company”), a leading contract research organization specializing in nonclinical and analytical drug discovery and development services and research models and related products and services, today announced that Robert Leasure Jr., President and Chief Executive Officer, and Beth Taylor, Chief Financial Officer, will participate in the upcoming 21st Annual Craig Hallum Institutional Investor Conference and Jefferies Global Healthcare Conference.
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Inotiv, Inc. to Participate in Upcoming Craig Hallum and Jefferies Investor Conferences
COPENHAGEN, Denmark, May 23, 2024 (GLOBE NEWSWIRE) -- Evaxion Biotech A/S (NASDAQ: EVAX) (“Evaxion” or the “Company”), a clinical-stage TechBio company specializing in developing AI-Immunology™ powered vaccines, today announces its participation in the American Society of Clinical Oncology (ASCO) Annual Meeting, where it will present positive immune data form its ongoing EVX-01 Phase 2 study. The study assesses the personalized cancer vaccine EVX-01 in combination with anti-PD1 therapy in patients with advanced melanoma. The conference will take place in Chicago, IL, from May 31 – June 4, 2024.
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Evaxion to Present New Positive Data from Ongoing Phase 2 Study on Lead Vaccine Candidate EVX-01 at the American Society of Clinical Oncology Annual...
Media ReleaseCOPENHAGEN, Denmark; May 23, 2024
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Genmab to Showcase Data in Various Patient Populations to be Presented at the American Society of Clinical Oncology (ASCO) Annual Meeting
Abstract released today highlights safety, pharmacodynamic and clinical response data with additional data to be presented in a poster session on June 1, 2024
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Kymera Therapeutics to Present New Clinical Data from Ongoing Phase 1 Trial of MDM2 Degrader KT-253 at ASCO Annual Meeting