Abstract released today highlights safety, pharmacodynamic and clinical response data with additional data to be presented in a poster session on June 1, 2024
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Kymera Therapeutics to Present New Clinical Data from Ongoing Phase 1 Trial of MDM2 Degrader KT-253 at ASCO Annual Meeting
WOBURN, Mass., May 23, 2024 (GLOBE NEWSWIRE) -- Replimune Group Inc. (NASDAQ: REPL), a clinical stage biotechnology company pioneering the development of a novel portfolio of oncolytic immunotherapies, today announced multiple presentations at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting being held in Chicago from May 31-June 4, 2024.
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Replimune to Present at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting
MONTREAL, May 23, 2024 (GLOBE NEWSWIRE) -- Theratechnologies Inc. (“Theratechnologies” or the “Company”) (TSX: TH) (NASDAQ: THTX), a biopharmaceutical company focused on the development and commercialization of innovative therapies, today announced Phase 1 data demonstrating signs of long-term efficacy and a manageable safety profile of its lead investigational peptide drug conjugate (PDC) candidate, sudocetaxel zendusortide (TH1902), in patients with solid tumors. The data will be presented in a poster session on June 1, 9:00 AM-12:00 PM CDT (abstract #3081, poster board #226) at the 2024 American Society of Clinical Oncology (ASCO) annual meeting, which is taking place May 31-June 4, 2024, in Chicago, IL.
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Theratechnologies’ Sudocetaxel Zendusortide ASCO 2024 Presentation Demonstrates Signs of Long-Term Efficacy and Manageable Safety Profile in...
Presentation Includes Positive Results from Interim Analysis of Phase 2 Clinical Trial of Prexigebersen in Acute Myeloid Leukemia (AML) Presentation Includes Positive Results from Interim Analysis of Phase 2 Clinical Trial of Prexigebersen in Acute Myeloid Leukemia (AML)
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Bio-Path Holdings to Present Data at American Society of Clinical Oncology (ASCO) Annual Meeting
NEEDHAM, Mass., May 23, 2024 (GLOBE NEWSWIRE) -- Candel Therapeutics, Inc. (Candel or the Company) (Nasdaq: CADL), a clinical stage biopharmaceutical company focused on developing multimodal biological immunotherapies to help patients fight cancer, today announced topline overall survival data from its phase 2 clinical trial of CAN-2409, a multimodal biological immunotherapy candidate, plus valacyclovir (prodrug), together with standard of care (SoC) immune checkpoint inhibitor (ICI) therapy in patients with Stage III/IV non-small cell lung cancer (NSCLC) inadequately responding to ICI (anti-PD-(L)1) therapy. The data will be presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, to be held in Chicago, May 31 to June 4, 2024, by Charu Aggarwal, MD, MPH, FASCO, Leslye M. Heisler Associate Professor for Lung Cancer Excellence at the Perelman School of Medicine, University of Pennsylvania and Co-Principal Investigator of the clinical trial.
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Candel Therapeutics Reports Prolonged Overall Survival in Phase 2 Clinical Trial of CAN-2409 for Advanced Non-Small Cell Lung Cancer (NSCLC) in...
Lifileucel TIL Cell Therapy in Combination with Pembrolizumab DemonstratesDeep, Durable Responses in Frontline Advanced Melanoma Patientsin IOV-COM-202 Clinical Study
NEW YORK, May 23, 2024 (GLOBE NEWSWIRE) -- IN8bio, Inc. (Nasdaq: INAB) a clinical-stage biopharmaceutical company developing innovative gamma-delta T cell therapies, today announced an upcoming presentation of updated results from its fully enrolled Phase 1 study of INB-200 at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, to be held May 31st - June 4th in Chicago, Illinois. INB-200 is evaluating autologous Drug Resistant Immunotherapy (DeltEx DRI) or chemotherapy resistant gamma-delta T cells as a potential first-line treatment for patients with newly diagnosed glioblastoma multiforme (GBM).
- Updated single agent dose escalation data continues to demonstrate that WTX-124 is well tolerated and clinically active in patients with checkpoint inhibitor therapy relapsed/refractory cancers -
WALTHAM, Mass. and BOULDER, Colo., May 23, 2024 (GLOBE NEWSWIRE) -- Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced positive updated lead-in data from the company’s ongoing Phase 3 PEAK trial evaluating the selective and potent KIT mutant inhibitor, bezuclastinib, in combination with sunitinib, in patients with Gastrointestinal Stromal Tumors (GIST). The data will be presented in a poster presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, IL on June 1. Cogent also announced today a new Phase 2 clinical trial of bezuclastinib plus sunitinib in later line GIST patients, sponsored by the Sarcoma Alliance for Research through Collaboration (SARC) and in collaboration with The Life Raft Group and Dana-Farber Cancer Institute.
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Cogent Biosciences Announces Positive Updated Lead-In Data from Ongoing Phase 3 PEAK Trial Evaluating Bezuclastinib in Combination with Sunitinib in...
NEW HAVEN, Conn., May 23, 2024 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN) today announced that two abstracts, including one for ARV-766 in prostate cancer and one for TACTIVE-K, a Phase 1b/2 clinical trial with vepdegestrant, a novel investigational oral PROteolysis Targeting Chimera (PROTAC®) ER degrader, in combination with Pfizer’s atirmociclib (PF-07220060), an investigational CDK4 inhibitor, were accepted for presentation at the 2024 American Society of Clinical Oncology Annual Congress held May 31 to June 4, 2024, in Chicago, IL.
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Arvinas Announces Upcoming Presentations at the 2024 American Society of Clinical Oncology Annual Congress
Administration of azenosertib combined with gemcitabine was well tolerated and resulted in clinically meaningful increase in event-free survival compared to historical comparators
NEW YORK and VIENNA, May 23, 2024 (GLOBE NEWSWIRE) -- HOOKIPA Pharma Inc. (NASDAQ: HOOK, ‘HOOKIPA’), a company developing a new class of immunotherapeutics based on its proprietary arenavirus platform, today announced positive updated results from its Phase 1/2 clinical trial of HB-200 for the treatment of human papillomavirus 16 positive (HPV16+) head and neck cancers. The data were published in the Company’s abstract for the ASCO 2024 Annual Meeting and support the Company’s pivotal Phase 2/3 trial design for HB-200 in combination with pembrolizumab in the first line setting.
Oral presentation to highlight activity of REGN7075 in combination with Libtayo from dose-escalation portion of trial in patients with microsatellite stable colorectal cancer, which has historically proven unresponsive to immunotherapy
The question of how to live a long, healthy life is increasingly at the forefront of medical research. While centuries ago some may have turned to finding mythical immortality-granting items like the Holy Grail, scientists now say that achieving longevity may rely on eating the right foods, adopting healthy habits, and remaining socially active.
Reaching your hundredth birthday means you become a member of a special club of centenarians. While researchers believe the number of centenarians was very low before 1900, today many more people are able to reach this ripe old age.
As of 2021, there were an estimated 573,000 centenarians globally. The United Nations expects that number to jump rapidly, with a reported estimate of 3.7 million by 2050.
What do centenarians do to help them reach triple-digit birthdays what is their secret? Medical News Today spoke with six experts to find out what the secret sauce behind longevity is.
In 2016, National Geographic Fellow Dan Buettner and his team published a study on what they found to be the secrets to longevity.
Dubbed the Blue Zones, Buettner identified five specific areas of the world where people consistently live over 100 years of age. These areas are:
These are places where human beings have lived manifestly longest, Buettner explained to Medical News Today. Theyve achieved the health outcomes we want: long lives largely free of chronic disease. Since only 80% of how long we live is dictated by disease, these peoples lifestyles and environments offer us instructions and clues for how we can set up our lives to live longer.
Within these five areas, Buettner discovered there were nine common practices that people followed that might explain their slower aging process. Called the Power 9, they include:
Loneliness, said Buettner, is a top risk factor for a shorter life, so preventing that as much as we can could help add years to our lives:
We know that lonely people are expected to live 8 fewer years than well-connected people and that health behaviors [are] measurably contagious. People in Blue Zones are in socially connected villages with strong social ties, which gives them a longevity edge from the very beginning.
Theres no short-term fix [or] supplement for longevity, he added. Learn plant-based dishes that you like and cook at home. Curate a social circle of three to five healthy friends [who] will care about you on a bad day. Health behaviors are contagious, and friends tend to be long-term adventures.
As diet makes up a few of the Power 9 learned from Blue Zones, Buettner has also launched the Blue Zone Food Guidelines that feature 11 recommendations reflecting how the worlds longest-living people ate for most of their lives.
If you want to know what a centenarian [did to live] to be 100, you have to know what they ate during their whole [life], he said. Working with Harvard for my book The Blue Zones Kitchen, we collected 155 dietary studies done in all Blue Zones over the past 80 years and averaged them.
It was clear that over 90% of their traditional dietary intake came from whole food, plant-based sources [and] was about 65% complex carbs, noted Buettner. The pillars of every longevity diet in the world are whole grains, nuts, greens, and other garden vegetables, tubers, and beans.
Dr. Valter Longo, Edna M. Jones Chair in Gerontology and professor of gerontology and biological sciences at the USC Leonard Davis School of Gerontology, developed the Longevity Diet after years of research into aging, nutrition, and disease.
The Longevity Diet, based on [the] five pillars of longevity, entails all of the everyday and periodic dietary habits that are associated with increased longevity and healthspan, he explained to MNT.
The main facets of the Longevity Diet include:
Because diet [is] intended as how and what we eat and not as a method to lose weight, [it] can regulate the genes that regulate the aging process, but also those that regulate the removal of damaged components of cells and the regeneration of parts of various tissues and organs, Dr. Longo added.
Additionally, previous research suggests that the Mediterranean diet can also provide benefits when it comes to longevity.
A review published in January 2020 concluded that the Mediterranean diet helps slow down the progression of aging and the onset of frailty in older age.
And research published in March 2021 says adhering to the Mediterranean diet may add years to a persons life.
According to Monique Richard, a registered dietitian nutritionist, owner of Nutrition-In-Sight in Johnson City, TN, and national media spokesperson for the Academy of Nutrition and Dietetics, when it comes to eating for longevity, diets like the Blue Zone Diet, Longevity Diet, and Mediterranean diet stand out because of the lifestyle components they share.
Examples of commonalities observed within these populations include more families and individuals growing and consuming their food [and] eating more whole foods, as in closest to what Mother Nature has made versus derived from a manufacturing plant, industrial farm, or fast food chain, she explained to MNT.
Overall intake and composition of these diets include less highly-processed foods, therefore often automatically decreasing levels of sodium, artificial flavors, colorings, and preservatives, fats or added sugar. Richard noted.
These dietary patterns often include foods lower in saturated fats, cholesterol, and calories, including more foods that are richer in nutrients such as fiber, antioxidants like vitamin C, E, A, [and] B, and higher in minerals such as potassium, magnesium, and iodine.
Monique Richard
When looking to make diet changes to increase longevity, Richard said it is not just about extending life, but also about increasing its quality.
She suggested:
The emphasis is not on restriction or negative consequences, but leaning into true quality, consistency, and overall health with a pillar of foundational pure, wholesome factors, Richard said.
Dont forget to slow down with eating, with chewing, with making or creating a meal, with making time to stop and smell the flowers, [and] with making long-lasting meaningful changes, she added.
The power of positive thinking is known to be beneficial to a persons overall mental health. However, previous research shows that a positive attitude may even help a person live longer.
A study published in August 2019 found that being optimistic was associated with a person living 11-15% longer and having a stronger likelihood of living to age 85 or older.
Research published in October 2022 suggested that positive-thinking women in an ethnically diverse United States population lived an average of 4.4 years more than those who did not think positively.
Having a positive, optimistic outlook reduces our risk for developing chronic diseases and gives us a greater chance of living past 85, Dr. Karen D. Sullivan, a board-certified neuropsychologist and owner of I CARE FOR YOUR BRAIN in Pinehurst, NC explained to MNT.
The mechanism behind these benefits is thought to be related to the protection optimism offers against the inflammatory damage of stress. Studies on negative emotions show a weakening effect on the immune system.
Dr. Karen D. Sullivan
Additionally, Dr. Karen Miller, a neuropsychologist, geropsychologist, and senior director of the Brain Wellness and Lifestyle Programs at Pacific Neuroscience Institute in Santa Monica, CA, noted that inflammation caused by stress is one of the culprits leading to more rapid aging, more physical difficulties, and more cognitive difficulties.
So when were thinking positive and engaging in positive behaviors, such as [] meditation, yoga, participating in our own personal religious practices, getting out and walking, exercising, [or] enjoying the fresh air, all those things are bringing down our stress and bringing down our level of inflammation, she continued.
If were under a lot of stress were going to have higher inflammation and higher inflammation actually can cause cellular damage to our bodies, particularly our brains, Dr. Miller noted.
In addition to staying positive and participating in activities that help lower stress, remaining socially active and connected to other humans has also been associated with living a long life.
A study published in September 2019 found women who had strong social relationships had a 10% longer life span and 41% better chance of living to age 85.
And research published in May 2023 showed that frequent participation in social activity was significantly associated with prolonged overall survival in older adults.
We are social beings with a social brain we are wired to be part of a group with needs for both contributing value and being valued, Dr. Sullivan explained.
People who identify as lonely have a [] greater risk of dying early than those who feel satisfied with their social life. The chronic stress of loneliness weakens our immune systems, making us more susceptible to infectious diseases and chronic diseases, especially cardiovascular disease and cancer.
Dr. Karen D. Sullivan
When actively socializing, Dr. Miller said, we are engaging in cognitive stimulation that helps keep the brain engaged and healthy.
When we are involved with another person, there is that volley, that give and take, she told MNT. Its like a tennis match the ideas are going back and forth. And that type of cognitive stimulation actually inspires our brains to be more mentally agile, or like what we like to think of in neuropsychology as cognitive flexibility.
Plus, conversing and engaging with others helps you learn more information, think creatively, and stimulate problem-solving skills, resulting in what Dr. Miller referred to as a whole-brain workout.
That type of engagement, that social stimulation, is what I would call natures brain bootcamp, she added. Were literally engaging in bootcamp for our brain where were socializing, which is very different than if I was isolated and I didnt have that opportunity.
While experts agree a healthy diet, limiting stress, thinking positively, and staying socially active can potentially lead to a longer life, there are some other healthy habits that are also important.
For example, smoking can take years off your life. A study published in June 2020 found that not smoking and being socially engaged throughout older age were common in centenarians free from common chronic diseases.
Keeping a healthy weight is also important for longevity. Research published in 2017 concluded that a high body mass index (BMI) was associated with substantially shorter healthy and chronic disease-free life expectancy.
Regular exercise can also help you live longer. A study published in August 2022 found that light or moderate to vigorous physical activity were both associated with a lower risk of mortality in older women, while higher sedentary time increased their mortality risk.
Several studies have shown that physical activity is associated with lower risk of mortality in older adults, Dr. Aladdin Shadyab, associate professor of epidemiology at the Herbert Wertheim School of Public Health & Human Longevity Science at UC San Diego, and senior author of the study told MNT.
We were the first to show that higher levels of physical activity and lower time spent sedentary are associated with reduced risk of mortality, irrespective of having genes that predispose to a long life. These findings overall highlight the importance of maintaining a physically active lifestyle in old age to achieve longevity, said Dr. Shadyab.
I think maintaining a healthy diet and engaging in regular exercise is most important, particularly for older adults, he added. Even light activities, such as walking, are important for maintaining a long and healthy life in the aging population.
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Longevity: What lifestyle habits could help you live to 100?
Helen Mongelia's 102 years reflect the mysterious alchemy of genetic, environmental, and lifestyle factors that coalesce to aid longevity. Fresh food, consistent movement, emotional resilience, and a family full of long-living relatives mark the centenarian's colorful life span, which began in 1919 while Woodrow Wilson occupied the White House.
Longevity like Mrs. Mongelia's remains extraordinary, with an estimated one in 6,000 people in the United States reaching 100 nowadays, according to the U.S. Administration on Aging. More than 100,000 were 100 or older in 2019, triple the number in 1980 who'd passed their 100th birthday.
Scientists, including those at Harvard, are eagerly studying people in their 90s and beyond to tease out what contributes to exceptionally long living. People enduring to extreme old age often have lifestyles that fuel vigor and hamper age-related chronic diseases such as heart disease, cancer, and diabetes. They typically are nonsmokers, are not obese, and cope effectively with stress, according to the National Institutes of Health (NIH). Most are women.
"I didn't expect to live this long, that's for sure," says Mrs. Mongelia, who lived independently until 101 when she also gave up driving and happily holds a mailroom job at her assisted living residence in Connecticut. "But I've tried not to let anything bother me too much. I have two great daughters, two sons-in-law, and two grandchildren what else can you ask for? There's my happiness right there."
Mrs. Mongelia never restricted her diet, eating meat but skipping most alcoholic drinks. But her early fare as the middle child of 11 was abundant in fruits and vegetables, many grown in her family's garden in Carbondale, Pa., and canned to enjoy all year long. The large clan also walked "everywhere," trekking miles round-trip to church, school, and the grocery store.
Mrs. Mongelia's healthy habits hit a sweet spot that science increasingly spotlights as optimal for longevity. A new Harvard-led study spanning 11 years and involving 2,400 people (average age 60; 55% women) suggests that a Mediterranean diet rich in fruits, vegetables, and healthy fats may dampen inflammation and prevent age-related frailty, a major predictor of decline affecting between 10% and 15% of older adults.
"Frailty is hard to define, but it's really easy to spot. In general, it's a state of increased vulnerability," says Courtney Millar, a postdoctoral research fellow at the Marcus Institute for Aging Research at Harvard-affiliated Beth Israel Deaconess Medical Center.
"It's important to focus on frailty prevention and treatment, because it's associated with so many of the factors that determine someone's longevity," says Millar, a co-author of the study, published online May 12, 2022, by The American Journal of Clinical Nutrition.
Another new study suggests that young adults who begin optimizing their diets at age 20 by veering from typical Western fare to more whole grains, legumes, and nuts could increase their life expectancy by more than a decade. Published online Feb. 8, 2022, by PLOS Medicine, the study posited that people who start such dietary shifts even at age 60 can still reap substantial benefits, increasing life expectancy by eight years for women; 80-year-olds could gain another three-plus years.
"I'm certainly a believer that food is medicine," Millar says, "and there's some great evidence that dietary factors can improve longevity."
Mrs. Mongelia's family is peppered with relatives who've had far longer-than-average life spans. Although her coal miner father died of black lung disease at 78, Mrs. Mongelia's mother lived to 93, and many siblings also thrived into their 10th decade. Two brothers still survive.
Research reinforces this link: siblings and children of long-living people are more likely to live beyond peers and remain healthier while doing so, according to the NIH. A study published online May 28, 2022, by The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences suggested that children of those who reach 100 carry a specific "genetic footprint" explaining why they're less frail than peers whose parents were not centenarians.
Might our genes be the linchpin to longevity? "My take is that it's certainly a combination of lifestyle and genetics," Millar says. "Certain dietary factors and even exercise regimens can modify how our genes are expressed and contribute to what's going on in our bodies. It's a really important intersection of our health."
Some scientists use the term "biohacks" to refer to tweaks in daily habits and choices that aim to tamp down inflammation and blunt aging's effects. Many of these tactics aren't new, but Harvard experts say that employing them consistently might contribute to longevity.
Move more. Vigorous movement has repeatedly been linked with lower risks of heart disease, diabetes, obesity, and other chronic health problems.
Review your health history. Talk to your primary care doctor about your health conditions and any new symptoms so you can manage them appropriately.
Try intermittent fasting. Compressing meals into a six- or eight-hour window each day boosts the body's natural process of eliminating damaged cells and proteins, lowering inflammation levels.
Eat a plant-forward diet. Antioxidants from fruits and vegetables and fiber from whole grains all help to lower inflammation levels. Beans, chickpeas, and other legumes were hailed as a key dietary predictor of longevity in a study that found a daily dietary increase of just 20 grams (less than an ounce) of legumes lowers our risk of dying in any given year by 8%.
Boost your outlook. List your life goals and imagine a future where they've been reached, or think about three good things that happened to you every day. Write them down.
Despite a hardscrabble path that included dropping out of school after 11th grade to take care of a baby sibling and also working as a button operator in a dress factory where she earned three cents per dozen buttons mounted Mrs. Mongelia maintains an upbeat attitude that matches her hardy body. She relies on a walker and hearing aids, but remains mentally sharp. "Just keep going and going and going, and don't give up," she counsels.
A recent Harvard-led analysis of nearly 160,000 American women linked positive outlook to extended life span. Published online June 8, 2022, by the Journal of the American Geriatrics Society, the study analyzed data and survey responses from women who were 50 to 79 years old when they enrolled in the study in the 1990s. The researchers then tracked participants' survival for up to 26 years. The results suggested that higher levels of optimism correlated with higher odds of living beyond 90.
About a quarter of the relationship between optimism and living longer may reflect health-related factors such as eating healthy foods, controlling weight, exercising, and limiting alcohol, says study co-author Dr. Hayami Koga, a researcher and doctoral candidate in population health sciences at the Harvard T.H. Chan School of Public Health.
The findings hint at the value of focusing on positive psychological factors as possible new ways of promoting longevity and healthy aging, Dr. Koga says. "There's some evidence that optimistic people are more likely to have goals and the confidence to reach them," she adds. "I think it drives people to be more confident and take actions that lead to better health."
Photo by Timothy H. Cole
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Aiming for longevity - Harvard Health
As medical and social advances mitigate diseases of old age and prolong life, the number of exceptionally long-lived people is increasing sharply. The United Nations estimates that there were about 95,000 centenarians in 1990 and more than 450,000 in 2015. By 2100, there will be 25 million. Although the proportion of people who live beyond their 110th birthday is far smaller, this once-fabled milestone is also increasingly common in many wealthy nations. The first validated cases of such supercentenarians emerged in the 1960s. Since then, their global numbers have multiplied by a factor of at least 10, though no one knows precisely how many there are. In Japan alone, the population of supercentenarians grew to 146 from 22 between 2005 and 2015, a nearly sevenfold increase.
Given these statistics, you might expect that the record for longest life span would be increasing, too. Yet nearly a quarter-century after Calments death, no one is known to have matched, let alone surpassed, her 122 years. The closest was an American named Sarah Knauss, who died at age 119, two years after Calment. The oldest living person is Kane Tanaka, 118, who resides in Fukuoka, Japan. Very few people make it past 115. (A few researchers have even questioned whether Calment really lived as long as she claimed, though most accept her record as legitimate based on the weight of biographical evidence.)
As the global population approaches eight billion, and science discovers increasingly promising ways to slow or reverse aging in the lab, the question of human longevitys potential limits is more urgent than ever. When their work is examined closely, its clear that longevity scientists hold a wide range of nuanced perspectives on the future of humanity. Historically, however and somewhat flippantly, according to many researchers their outlooks have been divided into two broad camps, which some journalists and researchers call the pessimists and the optimists. Those in the first group view life span as a candle wick that can burn for only so long. They generally think that we are rapidly approaching, or have already reached, a ceiling on life span, and that we will not witness anyone older than Calment anytime soon.
In contrast, the optimists see life span as a supremely, maybe even infinitely elastic band. They anticipate considerable gains in life expectancy around the world, increasing numbers of extraordinarily long-lived people and eventually, supercentenarians who outlive Calment, pushing the record to 125, 150, 200 and beyond. Though unresolved, the long-running debate has already inspired a much deeper understanding of what defines and constrains life span and of the interventions that may one day significantly extend it.
The theoretical limits on the length of a human life have vexed scientists and philosophers for thousands of years, but for most of history their discussions were largely based on musings and personal observations. In 1825, however, the British actuary Benjamin Gompertz published a new mathematical model of mortality, which demonstrated that the risk of death increased exponentially with age. Were that risk to continue accelerating throughout life, people would eventually reach a point at which they had essentially no chance of surviving to the next year. In other words, they would hit an effective limit on life span.
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How Long Can We Live? - The New York Times
The chorus of the theme song for the movie Fame, performed by actress Irene Cara, includes the line Im gonna live forever. Cara was, of course, singing about the posthumous longevity that fame can confer. But a literal expression of this hubris resonates in some corners of the worldespecially in the technology industry. In Silicon Valley, immortality is sometimes elevated to the status of a corporeal goal. Plenty of big names in big tech have sunk funding into ventures to solve the problem of death as if it were just an upgrade to your smartphones operating system.
Yet what if death simply cannot be hacked and longevity will always have a ceiling, no matter what we do? Researchers have now taken on the question of how long we can live if, by some combination of serendipity and genetics, we do not die from cancer, heart disease or getting hit by a bus. They report that when omitting things that usually kill us, our bodys capacity to restore equilibrium to its myriad structural and metabolic systems after disruptions still fades with time. And even if we make it through life with few stressors, this incremental decline sets the maximum life span for humans at somewhere between 120 and 150 years. In the end, if the obvious hazards do not take our lives, this fundamental loss of resilience will do so, the researchers conclude in findings published in May 2021 in Nature Communications.
They are asking the question of Whats the longest life that could be lived by a human complex system if everything else went really well, and its in a stressor-free environment? says Heather Whitson, director of the Duke University Center for the Study of Aging and Human Development, who was not involved in the paper. The teams results point to an underlying pace of aging that sets the limits on life span, she says.
For the study, Timothy Pyrkov, a researcher at a Singapore-based company called Gero, and his colleagues looked at this pace of aging in three large cohorts in the U.S., the U.K. and Russia. To evaluate deviations from stable health, they assessed changes in blood cell counts and the daily number of steps taken and analyzed them by age groups.
For both blood cell and step counts, the pattern was the same: as age increased, some factor beyond disease drove a predictable and incremental decline in the bodys ability to return blood cells or gait to a stable level after a disruption. When Pyrkov and his colleagues in Moscow and Buffalo, N.Y., used this predictable pace of decline to determine when resilience would disappear entirely, leading to death, they found a range of 120 to 150 years. (In 1997 Jeanne Calment, the oldest person on record to have ever lived, died in France at the age of 122.)
The researchers also found that with age, the bodys response to insults could increasingly range far from a stable normal, requiring more time for recovery. Whitson says that this result makes sense: A healthy young person can produce a rapid physiological response to adjust to fluctuations and restore a personal norm. But in an older person, she says, everything is just a little bit dampened, a little slower to respond, and you can get overshoots, such as when an illness brings on big swings in blood pressure.
Measurements such as blood pressure and blood cell counts have a known healthy range, however, Whitson points out, whereas step counts are highly personal. The fact that Pyrkov and his colleagues chose a variable that is so different from blood counts and still discovered the same decline over time may suggest a real pace-of-aging factor in play across different domains.
Study co-author Peter Fedichev, who trained as a physicist and co-founded Gero, says that although most biologists would view blood cell counts and step counts as pretty different, the fact that both sources paint exactly the same future suggests that this pace-of-aging component is real.
The authors pointed to social factors that reflect the findings. We observed a steep turn at about the age of 35 to 40 years that was quite surprising, Pyrkov says. For example, he notes, this period is often a time when an athletes sports career ends, an indication that something in physiology may really be changing at this age.
The desire to unlock the secrets of immortality has likely been around as long as humans awareness of death. But a long life span is not the same as a long health span, says S. Jay Olshansky, a professor of epidemiology and biostatistics at the University of Illinois at Chicago, who was not involved in the work. The focus shouldnt be on living longer but on living healthier longer, he says.
Death is not the only thing that matters, Whitson says. Other things, like quality of life, start mattering more and more as people experience the loss of them. The death modeled in this study, she says, is the ultimate lingering death. And the question is: Can we extend life without also extending the proportion of time that people go through a frail state?
The researchers final conclusion is interesting to see, Olshansky says. He characterizes it as Hey, guess what? Treating diseases in the long run is not going to have the effect that you might want it to have. These fundamental biological processes of aging are going to continue.
The idea of slowing down the aging process has drawn attention, not just from Silicon Valley types who dream about uploading their memories to computers but also from a cadre of researchers who view such interventions as a means to compress morbidityto diminish illness and infirmity at the end of life to extend health span. The question of whether this will have any impact on the fundamental upper limits identified in the Nature Communications paper remains highly speculative. But some studies are being launchedtesting the diabetes drug metformin, for examplewith the goal of attenuating hallmark indicators of aging.
In this same vein, Fedichev and his team are not discouraged by their estimates of maximum human life span. His view is that their research marks the beginning of a longer journey. Measuring something is the first step before producing an intervention, Fedichev says. As he puts it, the next steps, now that the team has measured this independent pace of aging, will be to find ways to intercept the loss of resilience.
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Humans Could Live up to 150 Years, New Research Suggests
The Rocky Mountain States, for example, have a lower prevalence of cancer death compared to the Gulf States, says Chrysohoou yet the background radiation in Idaho, Colorado and New Mexico is around three times as high as the natural background radiation in Louisiana, Mississippi and Alabama. A few animal studies have also found that a very low dose of radiation can induce an anti-inflammatory response and DNA repair possibly in the same way that the small but beneficial stress of caloric restriction can trigger protective mechanisms within cells.
For the time being, the finding remains a curiosity. Many more studies would have to confirm that these patterns cannot be explained by other factors and their potential mechanisms; Chrysohoou certainly isnt suggesting that radioactive drinks might be the elusive elixir of youth. It is rather dangerous to expect that radioactivity is good for your health, she admits.
The moderation principle
Clearly, exceptional longevity of the Blue Zones cant be restricted to a single magic ingredient, but is the combination of many factors some of which are shared between the regions, and some of which are unique to each individual place. While that may not be as enticing as the discovery of a miraculous anti-ageing elixir or superfood, there are nevertheless many ways we could learn from these discoveries.
Eating moderately with plenty of fruit and vegetables, exercising plenty, drinking coffee and tea, and finding space for spiritual solace (whether thats church or a long mountain walk) these are things that we can all build into our daily lives.
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* David Robson is the author of The Intelligence Trap, which examines why smart people act foolishly and the ways we can all make wiser decisions. He is @d_a_robson on Twitter.
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The ingredients for a longer life - BBC Future
Life expectancy is the statistical measure of the average time a person is expected to live. According to the World Health Organization (WHO), the global life expectancy as of 2016 was 72.0 years, 74.2 for females and 69.8 years for men. The average life expectancy at birth for the U.S. varies depending on the source. The latest figures are: 78.5 years, according to the OECD; 78.6 years, according to the CDC; 80.0 years, according to the CIA.
In general, life expectancy is based on two major factors: genetics and lifestyle choices. These include, but are not limited to: gender, access to quality health care, hygine, obesity, diet and nutrition, exercise, and crime rates. Overall, you can expect to see the highest life expectancies in the healthiest states. Additionally, women tend to live longer than men. American men expect to live an average of 76.1 years, while women expect to live an average of 81.1 years, a five-year difference.
Because the above factors vary greatly by state, so do life expectancies. On average, Hawaii residents live longer than residents in any other state, about 81.5 years, while Mississippi residents live the shortest lives at 74.6 years. This is a difference of 6.9 years. In general, the South has lower life expectancies than other parts of the country.
The ten states with the longest life expectancies, in order, are: Hawaii (81.5), California (80.8), Minnesota (80.8), New York (80.7), Connecticut (80.6), New Jersey (80.4), Colorado (80.0), Washington (80.0), Massachusetts (79.0), and Vermont (79.0). Hawaii has the longest life expectancy in the United States at 81.5 years. Women in Hawaii are the longest-living Americans at 84.3 years. If Hawaii were a country, it would have the 21st-highest longevity globally. Physical activity is high in the state, and its 25% obesity rate is the third-lowest nationwide. Low obesity rates are common in this list, with eight of the ten states having obesity rates at 28.3% or lower. Colorado has the lowest at 23.8%.
The ten states with the lowest life expectancies, in order, are: Mississippi (74.6), West Virginia (74.9), Alabama (74.9), Kentucky (75.1), Arkansas (75.4), Oklahoma (75.5), Louisiana (75.5), Tennessee (76.1), South Carolina (76.2), and Ohio (76.6). Mississippi's longevity is the lowest in the United States at 74.6 years. Mississippi men live the shortest lives on average of 71.4 years. Mississippi is the most obese state, with 40.8% of adults being obese. Unsurprisingly, nine of the ten most obese states are also on the list of the ten states with the shortest life spans. In general, Louisiana, Mississippi, Alabama, Oklahoma, and Arkansas are considered the least-healthy states, with high rates of obesity, excessive drinking, cancer, and heart disease, and low-quality health care.
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Life Expectancy by State 2023 - World Population Review
We the Founders and leadership of Fountain Life seek to build a global company delivering the most advanced diagnostics and vetted therapeutics to those who seek a longer, healthier and more vital life.
We seek to extend member healthspan by using a foundation of functional medicine-based protocols plus an annual 150 Gb Upload of imaging, genetic and blood-related diagnostics. Our goal is to reliably predict future disease, and to detect any such disease at the earliest moment possible, thereby stopping and ultimately reversing its progression, returning our member to peak performance.
Fountain and its network of physicians and scientists are constantly scanning the world searching for low-risk, high-reward therapeutic treatments. Once vetted, those treatments with the greatest promise are made available to all members through our Centers. Fountain requires that treatments delivered to its members are either FDA approved, or delivered under an approved investigational protocol.
Fountain believes that there is no substitution for a brilliant and thoughtful medical team delivering healthcare services. As such, we have developed an innovative care model, utilizing a vertically integrated, 6-person healthcare team. Each Fountain Member is supported by a Concierge Physician, Nurse Practitioner, and a group of four health care coordinators and coaches. These teams are trained to the highest standards at Fountain University in accordance with A4M, the Functional Medical Institute and other cutting edge partnerships.
Finally, Fountain also is making use of the most advanced artificial intelligence technologies available in order to enable a smooth and seamless member experience, while at the same time mining our vast data-set to glean personalized insights capable of bestowing lifesaving consequences.
In Health,Fountain Lifes Founders & Leadership
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About Us - Fountain Life