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A new study has found elderly men with existing cardiometabolic disease with a version of a gene associated with longevity and aging in humans appeared to have a reduced risk of death.

The gene in question, Forkhead Box O3 (FOXO3) has long been highlighted in the past as being important in the aging process.

Chronic cardiometabolic diseases of aging such as diabetes, heart disease, and high blood pressure increases the risk of death and a shorter lifespan.

The study followed 3,584 men from the Kuakini Honolulu Heart Program in Honolulu, Hawaii, to examine the effects of the longevity version (alleles) of the FOXO3 gene in men with cardiometabolic diseases and found they lived just as long as men who did not have the disease.

The findings were presented in a paper published in Aging

The work was conducted by an international team, including researchers at the University of Sydney and the University of Hawaii.

Emeritus Professor Brian Morris from the Faculty of Medicine and Health, University of Sydney was corresponding author on the paper.

We have found for the first time that the remaining lifespan of elderly men with longevity associated alleles (versions) of FOXO3 who have one of more chronic conditions of ageing, such as diabetes and hypertension live as long as elderly men who lack any of these lifethreatening conditions, says Emeritus Professor Morris.

This suggests that expression of this particular version of FOXO3 in humans appears to impact what would otherwise be an increased risk for mortality in men with prevalent cardiometabolic conditions.

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Longevity gene could be key in reducing risk of death for men with chronic disease - News - The University of Sydney

With a year which has shook many to their cores, putting your health as a priority has never been more important. By quitting smoking, avoiding binge drinking, finding healthy hobbies which bring you joy and eating a varied diet rich in fruits and vegetables you could help boost your longevity by a whopping 10 years.

In a study published in the US National Library of Medicine National Institutes of Health, a Mediterranean diet for an added 10-year mortality in elderly European men and woman was investigated.

The study noted: Dietary patterns and lifestyle factors are associated with mortality from all causes, coronary heart disease, cardiovascular diseases, and cancer, but few studies have investigated these factors in combination.

The study included 1507 apparently healthy men and 832 women, aged 70 to 90 years in 11 European countries.

The study found that by making healthier choices and following a more varied diet including the Mediterranean diet, premature death risk was lowered, as well as a reduced risk of cancer, metabolic syndrome, heart disease, depression and brain deterioration.

READ MORE:Best supplements for the heart - the 2p capsules to protect against heart disease

We are all aware of how binge drinking can negatively affect not only our physical health but our mental health too.

With the Christmas season in full swing its easy to be over drinking, however, heavy alcohol consumption is linked to liver, heart, and pancreatic disease, as well as an overall increased risk of early death.

Moderate alcohol consumption is associated with a reduced likelihood of several diseases, as well as a 17 to 18 percent decrease in your risk of premature death.

To keep consumption moderate, it is recommended that women aim for one to two units or less per day and a maximum of seven per week.

Men should keep their daily intake to less than three units, with a maximum of 14 per week.

Its a no brainer that cigarette smoking is linked to a number of serious health conditions including cancers and diseases.

A study looked at the 21st century hazards of smoking and benefits of stopping.

Interesting the study found that among UK women, two-thirds of all deaths of smokers in their 50s, 60s, and 70s are caused by smoking; smokers lose at least 10 years of lifespan.

Although the hazards of smoking until age 40 years and then stopping are substantial, the hazards of continuing are ten times greater.

Stopping before age 40 years (and preferably well before age 40 years) avoids more than 90 percent of the excess mortality caused by continuing smoking; stopping before age 30 years avoids more than 97 percent of it.

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How to live longer: Four habits to implement in your life to boost longevity by 10 years - Express

About eighty per cent of our longevity and health is determined by our epigenome and by not our DNA and we can change our epigenome by how we live, Dr David Andrew Sinclair, professor of genetics and co-director of the Paul F Glenn Center for the Biology of Aging Research at Harvard Medical School, told Hindustan Times health editor, Sanchita Sharma on Friday.

Dr Sinclair talked about some minor dietary and lifestyle tweaks that can turn on the bodys defences against ageing and help promote longevity and good health.

He said that eating three regular meals a day will not give the best results for longevity, instead, skip a meal in a day.

What I do is that I skip a meal in a day and I try not to snack but have tea or coffee, he said.

Dr Sinclair however said that young people should not skip a meal, older and middle-aged people can skip a meal in a day.

Also read: With Covid-19 vaccine coming, economic recovery will gain traction - FM

Dont skip breakfast, may skip lunch or dinner depending on the individual, this is for middle-aged or older people who have slightly slower metabolism, he said, adding that he isnt promoting starvation.

Dr Sinclair explained that longevity factors get turned on when a person remains hungry for a brief spell. If we sit around the whole day, keep eating and dont feel hungry, our bodies will relax and stop fighting ageing, he explained.

He also discussed some other ways to turn on the bodys defences against ageing:

Lose your breath from exercise.

Do hip-hinges exercises, weight-lifting. Keep your hips strong.

Use biomarker feedback. Monitor your health level, track your vitals and see hows the body performing on a daily basis.

Sleep well and reduce stress.

Eat plants that have been stressed, for example, wine is made from grapes that have been stressed.

Dr Sinclair appeared on the cover of the Time Magazines 100 most influential people in the world. Besides Sinclair, the sixth day of HTLS 2020 saw Union finance minister Nirmala Sitharaman and YOOX Net-a-Porter Groups Federico Marchetti in participation.

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Skip a meal: Harvard expert Dr Sinclairs tips on how to live healthy, longer - Hindustan Times

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Davante Adams saw on social media last week that Aaron Rodgers needed three touchdowns to hit 400 for his career. Adams caught the first; Robert Tonyan caught the second; and after Adams caught the third, he presented the ball to the Packers quarterback.

Yeah, that was a special moment, Rodgers said. I can remember all the hundred notches. I said after the game in an interview this will be the first out of those that I actually probably will get the ball. . . . [The receivers] didnt say a whole lot during the week. Its always interesting to see who gets the milestone throw. It was pretty cool that Davante got it. I didnt do a whole lot on that play. It was a really good scheme and play. He did the whole thing and stiff-armed his way into the end zone.

Its fun to have those milestones in back-to-back weeks. Like I said last week, a lot of it is longevity, but there also is some consistent play tied to it.

Rodgers became the fastest quarterback ever to reach 400 career passing touchdowns, and the seventh ever to hit the milestone.

Buccaneers quarterback Tom Brady is the all-time leader with 569 touchdown passes and counting with Saints quarterback Drew Brees on injured reserve with 565.

Rodgers last week became the 11th player in NFL history to reach 50,000 career passing yards.

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Aaron Rodgers sets another milestone with 400th career touchdown - NBC Sports - NFL

Lockdown 2.0 might have lifted, at least in some places. But for those who want to wait for a vaccine before returning to the gym, and with jogging and cycling in the cold and wet an altogether grimmer prospect than it was in March, it is no wonder that online sales of home exercise equipment have rocketed.

According to figures released by eBay last month, sales of strength and weight training equipment shot up by 500 per cent after the autumn restrictions were announced, while cardio machine sales rose by 200 per cent. Rather than flour, this time panic buyers stocked up early on dumb-bells and yoga mats. And as Christmas approaches, retailers are banking on a bumper year.

Nothing illustrates just how fit-kit crazy weve become these past weeks than the fact that, on Amazon, a device called the OOTO Upgraded Boxing Reflex Ball is now a bestseller. It is, essentially, a ball on a string, attached to a headband and swatted by the user, like an oversized cat toy. Bizarre, but popular, if you believe the sales algorithms.

Purchasing home exercise kit can be bewildering and expensive, as any Peloton owner will tell you. Which is why I tested a range of more affordable products that will likely find themselves on this years Christmas lists.

Read the rest here:
The best affordable fitness kit to help you work up a sweat indoors this winter - Telegraph.co.uk

Aspart of a study, scientists from Australian Institute of Marine Science in the Rowley Shoals have discovered an 81-year-old midnight snapper, which is considered to be the oldest tropical reef fish in the world. As per the study, Snappers are highly valued by the global fisheries. Also, they are a large component of catches of tropical and subtropical multispecies fishery and are often associated with other meso-predators such as epinephelids and lethrinid.

The research shows that the species of the genus Lutjanus have some of the greatest recorded longevity among tropical reef fishes, with maximum recorded ages of 55 years. Extended longevity is usually the trait of species that live in environments where recruitment success is highly variable and is thought to be a hedge-betting strategy. This ensures that recruitment events coincide with species that live in environments where recruitment success is highly variable and is thought to be a hedge-betting strategy. The study focusses onthree species that are not targeted by fishing in the region: the red bass (Lutjanus bohar), midnight snapper (Macolor macularis), and black and white snapper (Macolor niger).

Read:Oral Drug Blocks Coronavirus Transmission In Ferrets Within 24 Hours: Study

Also, 10 other fishes, which were more than 60-year-old were identified in the Rowley Shoals in 1977. One of these 10 fishes was 79-year-old. The study says that exceptional longevity was discovered in all species. Also, corresponding patterns of age-based demography that varied predictably across latitude were observed. L. bohar and M. macularis were identified as the longest-lived reef-associated fishes from the tropics recorded to date, with a single L. bohar from the Rowley Shoals.

Read:China's Nonsensical Study Claiming COVID's Origin Is India Called Out; CSIR Tears It Apart

The study said, These estimates are two decades greater than that of any fish species from this environment ever recorded; overall, we recorded seven L. bohar and four M. macularis >_ 60 yrs .Published in the Journal named 'Coral Reefs', the research focusses onfour locations along the Western Australia coast, as well as the protected Chagos Archipelago in the central Indian Ocean. Thesnapper is thought to have been born in 1935. However, the elderly sea bass hatched during the First World War.

Read:Baby Goat Missing From Old 'Big Fish' Movie Set In Alabama

Also Read:AC Valhalla Guide: Learn How To Fish With The Help Of This AC Valhalla Fishing Guide

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Worlds oldest tropical fish found in Australia survived WWII, can you guess its age? - Republic World

Advised nutrition tips to improve better health and longevity!

Good nutrition is a critical part of health and development. According to the World Health Organization (WHO), better nutrition is related to improved health at all ages, a lower risk of diseases, and longevity.

People can find it difficult or confusing to navigate the amount of nutrition information now available, and many sources have differing views.

This article offers science-based nutrition tips to help someone lead a healthier lifestyle.

Following these nutrition tips will help a person make healthy food choices.

Including some protein with every meal can help balance blood sugar.

Somestudiessuggest higher protein diets can be beneficial for type 2 diabetes.

Otherresearchindicates balancing blood sugar can support weight management and cardiovascular health.

According toresearch, omega-3 fatty acids in oily fish are essential for cell signaling, gene expression, and brain and eye development.

Somestudiesindicate that omega-3 fatty acids can reduce the risk of cardiovascular disease.

Otherresearchsuggests the anti-inflammatory properties of omega-3 may effectively manage the early stages of degenerative diseases such asAlzheimers diseaseandParkinsons disease.

TheAmerican Heart Association (AHA)recommend people eat whole grains rather than refined grains.

Whole grains contain nutrients such as B vitamins, iron, and fiber. These nutrients are essential for body functions that include carrying oxygen in the blood, regulating the immune system, and balancing blood sugar.

The saying eat a rainbow helps remind people to eat different colored fruits and vegetables.

Varying the color of plant foods means that someone gets a wide variety of antioxidantsbeneficialto health, for example, carotenoids and anthocyanins.

Dark green leafy vegetables are a great source of nutrition, according to theDepartment of Agriculture (USDA).

Leafy greens are rich in vitamins, minerals, and antioxidants.

The USDA suggest that folate in leafy greens may help protect against cancer, while vitamin K helps prevent osteoporosis.

People should limit their intake of saturated fats while avoiding trans fats, according to theUSDA.

A person can replace these fats with unsaturated fats, which they can find in foods such as avocado, oily fish, and vegetable oils.

As part of the Mediterranean diet, extra virgin olive oil has benefits to the heart, blood pressure, and weight, according to a2018 health report.

A person can include extra virgin olive oil in their diet by adding it to salads or vegetables or cooking food at low temperatures.

According to theAHA, eating one serving of nuts daily in place of red or processed meat, french fries, or dessert may benefit health and prevent long-term weight gain.

The AHA suggest that Brazil nuts, in particular, may help someone feel fuller and stabilize their blood sugar.

According to theAHA, fiber can help improve blood cholesterol levels and lower the risk of heart disease, obesity, and type 2 diabetes.

People can get enough fiber in their diet by eating whole grains, vegetables, beans, and pulses.

Researchsuggests that plant-based diets may help prevent overweight and obesity. Doctors associate obesity with many diseases.

According to some studies, including more plant foods in the diet couldreducethe risk of developing diseases such as diabetes and cardiovascular disease.

Beans and pulses are a good source of protein for people on a plant-based diet. However, those who eat meat can eat them on a few meat-free days a week.

Beans and pulses also contain beneficial fiber, vitamins, and minerals.

Someresearcheven says pulses may help people feel fuller and lose weight.

Drinking plenty of healthy fluids has numerous health benefits. Health experts recommend these tips:

Drinking enough water every day is good for overall health and can help manage body weight, according to theCenters for Disease Control and Prevention (CDC).

Drinking water can prevent dehydration, which can be a particular risk forolder adults.

If someone does not like plain water, they can add some citrus slices and mint leaves to increase the appeal, or drink herbal teas.

A2017 studysuggests that moderate coffee consumption of 35 cups a day can reduce the risk of:

According to the same review, the recommended amount reduces to 2 cups per day for pregnant and lactating people.

According toresearch, catechins in green, black, and other herbal teas may have antimicrobial properties.

Herbal teas, such as mint, chamomile, and rooibos, are caffeine-free and help keep someone hydrated throughout the day.

It is important to cut back on food and drink that may have harmful health consequences. For example, a person may want to:

According toresearch, dietary sugar, dextrose, and high fructose corn syrup may increase the risk of cardiovascular disease and metabolic syndrome.

People should look out for hidden sugars in foods that manufacturers label as names ending in -ose, for example, fructose, sucrose, and glucose.

Natural sugars, such as honey and maple syrup, could also contribute to weight gain if someone eats them too often.

Dietary Guidelines For Americansrecommend that if someone consumes alcohol, it should be in moderation.

They advise up to one drink per day for females and up to two drinks per day for males.

Excessive drinking increases the risk of chronic diseases and violence, and over time, can impair short and long-term cognitive function.

TheCDCassociate frequently drinking sugary drinks with:

People should limit their consumption of sugary drinks and preferably drink water instead.

A large prospective study in theBritish Medical Journalindicates that U.S. adults eating more red and processed meat had higher mortality rates.

Participants who swapped meat for other protein sources, such as fish, nuts, and eggs, had a lower risk of death in the eight-year study period.

According to a review inNutrients, eating ultra-processed foods can increase the risk of many diseases, including cancer, irritable bowel syndrome, and depression.

People should instead consume whole foods and avoid foods with long lists of processed ingredients.MEDICAL NEWS TODAY NEWSLETTERStay in the know. Get our free daily newsletter

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There are several steps a person can take to improve their health in addition to consuming healthful foods and drinks.

A 2019 review inNutrientssuggests that a high quality, balanced diet supports microbial diversity and can influence the risk of chronic diseases.

The authors indicate that including vegetables and fiber are beneficial to the microbiome. Conversely, eating too many refined carbohydrates and sugars is detrimental.

The recommended dietary allowance for vitamin D is15 micrograms or 600 international unitsper day for adults.

Many people get some of their vitamin D from sunlight, while it is also in some foods.

People with darker skin, older adults, and those who get less exposure to sunlight such as during winter or in less sunny climates may need to take a vitamin D supplement.

Being aware of portion sizes can help people manage their weight and diet.

TheUSDAhave helpful information about portion sizes for different food patterns.

People can adapt the guidelines to suit their cultural or personal preferences.

Using herbs and spices in cooking can liven up a meal and have additional health benefits.

A2019 reviewsuggests that the active compounds in ginger may help prevent oxidative stress and inflammation that occurs as part of aging.

Curcumin in turmeric is anti-inflammatory and may have protective effects on health, according toresearch.

Garlic has manybenefits, including anti-inflammatory, antimicrobial, and antioxidant properties.

Intermittent fasting involves not eating either overnight or some days of the week. This may reduce energy intake and can have health benefits.

According to a2020 review, intermittent fasting may improve blood pressure, cholesterol levels, and heart health.

TheAmerican Society for Nutritionsay that keeping a food journal can help people track calories, see how much they are eating, and recognize food habits.

Keeping a food journal could help someone who wants to maintain a moderate weight or eat a more healthful diet.

Apps, such asMyFitnessPal, can also help someone achieve their goals.

Raw fruits and vegetables can contain harmful germs that could make someone sick, according to theCDC. They advise thatSalmonella, E.coli,andlisteriacause a large percentage of U.S. foodborne illness.

Always wash fresh produce when eating them raw.

Researchsuggests that microwaving food in plastic containers can release phthalates, which can disrupt hormones.

Experts recommend heating food in glass or ceramic containers that are microwave-safe.

Many people eat the same meals regularly. Varying foods and trying different cuisines can help someone achieve their requirednutrient intake.

This can be particularly helpful when trying to eat a broader range of vegetables or protein.

In a2017 study, mindful eating helped adults with obesity eat fewer sweets and manage their blood glucose.

Anotherstudysuggests mindfulness can bring greater awareness to food triggers and habits in people with diabetes.

Nutrition is an essential part of health, and people can start leading a healthful lifestyle by making small changes to their diet.

It is also important to remember other key aspects of health, such as exercise and activity, stress strategies, and adequate sleep.

Source: Advised nutrition tips to improve better health and longevity! THE HOLLYWOOD MIRROR

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Advised nutrition tips to improve better health and longevity! - Vancouver Health Coach

How we grow our food has a really big impact on the quality of that food and that means that when the quality of the food is better, the quality of your health and the quality of our planet is better explains Mary Purdy, Rd, Integrative & Eco-Conscious Registered Dietitian, on her podcast.

No matter how many times you enjoy a salad for lunch, the nutritional value thats on your plate has already been determined long before you placed your order.

Agricultural techniques that are more eco-friendly tend to make produce and foods that are healthier for you explains Mary.

We all want to consume food rich in nutritional value. However, in order to do this, we need to be conscious of how our food is produced and presented. Not many people think that food production can have a great impact on the nutritional quality of food, especially when you realize that the nutritional value of food has faced a steady decline.

Dont believe us? Well, one study found that, between 1975 and 1997, average calcium levels in 12 vegetables dropped by 27%, vitamin A levels by 21%, and vitamin C levels by 30%. A separate British study found that between 1930 and 1980, the average calcium content had depleted 19%, iron 22%, and potassium 14%.

So whats the reason for the decline in the nutritional value of our food? The answer is a simple one: soil depletion. The fact of the matter is that if we really want total control of our health, of the quality of our food, and frankly the longevity of our planet, then we need to learn to take better care of our soil microbiome.

The soil microbiome is this neuro-network in the plant that can affect the plant at a genetic level. If we can create healthy soil, not only will it help sequestrate carbon (reduce the amount ofcarbondioxide in the atmosphere with the goal of reducing global climate change) but it will also help to retain water. For every 1% soil organic matter that we build on our farm, we can retain 170 000 gallons of water per acre explains CEO and co-founder of Nutrition for Longevity Jennifer Maynard, who also has a twenty-plus year career in biotech and pharmaceutical medicine area, When you are building up that soil organic matter, youre creating an environment for the soil microbiome to thrive and this builds up phytonutrients which are essentially superfoods rich in color and nutrients.

A United Nations report revealed that a third of the planets land was severely degraded through erosion, salinization, compaction, acidification, and chemical pollution, and fertile soil was being lost at a rate of 24bn tonnes a year. Its easy to see why so much focus has been placed on the health and quality of the soil.

If we really want to protect the health of our soil, then its best to re-evaluate our farming practices. We may need to turn away from commercial farming practices to something more sustainable like regenerative farming.

Regenerative farming is all about reconstructing the soil. A lot of current agricultural practices are all about constructing the soil. Its all about pillage and getting rid of as many weeds as possible. This is done in a very mechanized way that is low on labor costs and often using a lot of chemicals explains Maynard, who goes on to mention that the US used to have, on average 11% soil organic which is an indicator of soil structure and now they have an average 1% and this is why regenerative farming is becoming a hot topic.

In 2015, the then UN Director-General Jos Graziano da Silva warned at the time that Further loss of productive soils would severely damage food production and food security, amplify food-price volatility, and potentially plunge millions of people into hunger and poverty.

As mentioned, the purpose of regenerative farming is to improve the health and quality of the soil. According to Maynard, theyve noticed 700 times less soil erosion by using regenerative farming. Furthermore, healthy soil means a healthy soil microbiome and this means a healthier you.

In fact, a study published in PLoS One found that a healthy soil microbiome full of necessary bacteria is more likely to produce nutrient-dense food, which can then promote better health.

The Intergovernmental Panel on Climate Change (IPCC), which is the United Nations body for assessing the science related to climate change, found that 23% of the total global greenhouse gas GHG emissions are directly related to agriculture, forestry, and other types of land use. That said, a report from the Rodale Institute, a nonprofit organization that supports research into organic farming, regenerative farming has the potential to reduce climate change instead of contributing to it.

How so?

By helping to maximize the carbon dioxide pulled from the atmosphere by plant growth and minimize the loss of that carbon once it is stored in the soil.

Infiltration refers to the soils ability to absorb and hold water, which means less runoff. This then translates to less erosion and pollution as a result of the reduction in runoff water.

According to the Food and Agriculture Organization of the United Nations, natural springs that had dried up many years ago, have begun to flow again due to new regenerative farming practices.

Regeneratively grown plants are put under more stress because we dont use chemicals to defend them. So, they have to draw on their microorganisms to cope with stress. One of the main mechanisms that they do is communicate with the plant to create more phytonutrients, explains Maynard.

Phytonutrients are chemicals found in plant products that help to provide antioxidant and anti-inflammatory benefits. Studies have found that they exist in abundance when it comes to non-commercially farmed produce.

A study from Newcastle University found that organic fruits and vegetables deliver between 20 and 40 percent more antioxidants than conventional fruits and vegetables. Additionally, a separate study published in theBritish Journal of Nutrition found that organic dairy and meat contain about 50% more omega-3 fatty acids.

Theres still a long way to go before we can adopt regenerative farming as the new method of farming. In the meantime, we can look at other innovative ways of producing food.

One such technique could be aquaponics. Maynard describes it as an ancient farming technique that can be traced back to the Aztecs, and which uses about 1% of the water of conventional farming.

With aquaponics, you grow fish and other aquatic animals in an effort to grow plants without soil. The plants are fed the aquatic animals waste and, in return, the vegetables clean the water that goes back to the fish. While this happens, microbes gather in the spaces between the roots of the plant and convert the fish waste and the solids into substances the plants can use to grow.

Maynard sees it as a farming technique that is still environmentally friendly and which allows us to grow food worldwide, especially with the rise in natural disasters.

If you want to start making little changes, start asking where your food comes from. In addition, to shopping organic, you can also start to grow a little of your own food. According to Maynard, once people understand how challenging it is to grow food, theyll likely become more conscious about their food waste.

Davis, D. R., Epp, M. D., & Riordan, H. D. (2004). Changes in USDA food composition data for 43 garden crops, 1950 to 1999.Journal of the American College of Nutrition,23(6), 669682. https://doi.org/10.1080/07315724.2004.10719409

Mayer, Anne-Marie. (1997). Historical changes in the mineral content of fruits and vegetables. British Food Journal. 99. 207-211. 10.1108/00070709710181540.

Reganold, J. P., Andrews, P. K., Reeve, J. R., Carpenter-Boggs, L., et al. (2010). Fruit and soil quality of organic and conventional strawberry agroecosystems.PloS one,5(9), e12346. https://doi.org/10.1371/journal.pone.0012346

rednicka-Tober, D., Baraski, M., Seal, C. J., Sanderson, R., et al. (2016). Higher PUFA and n-3 PUFA, conjugated linoleic acid, -tocopherol and iron, but lower iodine and selenium concentrations in organic milk: a systematic literature review and meta- and redundancy analyses.The British journal of nutrition,115(6), 10431060. https://doi.org/10.1017/S000711451600034

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You Really Need To Care About How Your Food Is Grown - Longevity LIVE

Abstract

Neutralizing antibody responses to SARS-CoV-2, though often of limited longevity, have generally been assumed to be protective against COVID-19 disease.

Prior analyses on thoracic lymph nodes and peripheral blood suggested a dysregulated humoral immune response early in COVID-19, including defective bcl-6+ follicular helper T cell TNF- production and loss of transitional and follicular B cells in severe disease. The cumulative data from recent publications suggested association of an aberrant extrafollicular (EF) B cell response with COVID-19 disease course. Prior work by Woodruff et al. characterized a unique group of IgD and CD27 double-negative (DN) EF B cells in systemic lupus erythematosus, associating the CXCR5negCD21negCD11c+ (DN2) subset with increased disease activity and poor clinical outcomes.

By applying this knowledge to high-dimensional B cell phenotyping stratified according to clinical COVID-19 disease severity, the authors not only validate previously known immune associations including elevated plasma IL-6 concentration, but also reveal that patients with life-threatening COVID-19 demonstrate significant expansion of peripheral blood DN2 cells, activated nave B cells, and antibody secreting cells (ASCs). They delineate a CD21negCD11cneg (DN3) B cell population that, when elevated in blood with two other EF populations including DN2 cells, associates with critical illness and high mortality in COVID-19 patients despite early neutralizing antibody responses. Elevated plasma C-reactive protein (CRP) also correlated with COVID-19 disease severity. The cumulative data offer a new perspective on pathogenic B cell responses in COVID-19 and support hypothesis-driven testing of the combined serum and B-lineage immune signature as a biomarker panel to screen for high-risk COVID-19 disease during infection and therapeutic interventions. These studies also provide insights into B cell effector pathways to consider in targeted immune therapies and COVID vaccine development.

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B careful: Humoral responses and COVID-19 severity - Science

The Premier Leagues longest-serving manager is discussing the concept of dynasty in football when, somewhere along the way, he ends up at birthday meals.

When I was growing up you went out for dinner for special birthdays, Sean Dyche recalls.

Now, families go out once, twice a week. Its part of the culture of life. This is life developing.

Dyches point is that the shift in modern culture has some good sides as well as the bad that, he believes, modern football reflects, causing the ferocious turnover of managers.

The average life expectancy of a manager now is around 14 months, Dyche says, compared to three years in the 1990s. The trouble now is the demand for change is almost instant, he tells i. Everyone wants the fridge delivered a day earlier, and they want a longer warranty. And why isnt it cheaper? And we all get on the internet and search around.

We use it for two years and decide even though theres nothing wrong with it we want something else, so we get rid of that. We get a new one in. That kind of mentality is in life, therefore the chances are its going to go into your thinking in sport. Thats why the culture is changing.

Dyche has agreed to this interview after launching the Sean Dyche Family Scholarship, a 15,000 sponsorship spread over three years for a prospective student at the University Campus of Football Business. But as we twist and turn through topics, it transcends into The World According to Sean Dyche: probabilities, possibilities, modern culture, longevity, his football philosophy.

Towards the end he will describe it as the longest interview ever. Are we doing a book? he asks. Though it would take more than one or possibly a Lord of the Rings-esque tome to fit in everything Dyche knows and thinks about life and football.

When Dyche gets going he sounds more like a young tech entrepreneur pitching their latest mobile app to venture capitalists, on the verge of sealing an investment worth hundreds of millions. Fast-talking, passionate, brimming with ideas. Not a man nearing his half century who has become a stalwart of English football and a household name after eight years spent at Burnley.

There are few managers who can discuss with such authority the ingredients for longevity at a football club. Perhaps Sir Alex Ferguson with his 26 years at Manchester United, Arsene Wenger with 21 at Arsenal, David Moyes with 11 at Everton.

So how has Dyche done it in the modern era when managerial lifespans have shrunk?

Having good staff who are different people to you, so you get real opinions rather than everyone joining in with my opinion thinking Im right, because Im not always right, he explains. Only 99.9999 per cent of the time.

The players are vital, recruitment is vital. Weve got a good alignment at Burnley. When I first joined the one thing I mentioned was a one-club mentality. I really believe in it. Most successful football clubs have a unity running through them. It sounds easy, but its not easy to build that mentality and get all noses pointed in the right direction.

Ive a good feeling about the way we work: the respect, the authenticity, the honesty of the way people are here, the way they treat people.

Dyches view of football management is shaped not by those longstanding managers who came before, but by his 20-year playing career. I was a bit of a journeyman, he says.

He didnt play regularly in the Premier League, but he played everywhere else, and won four promotions. Only during one of them did he realise the signs of longevity were missing, at Bristol City. True to that hunch, they were relegated the following season.

I remember even as a player thinking theres an alignment through the club, the manager, the coaches, the staff, the players, the delivery of the performance, the fans gluing into what the team stands for.

He learnt about alignment and how business worked from his dad, Alan, who was a management consultant for British Steel. And, he adds, I had an instinct for it.

And off we go: A lot of it involves simple things. Honesty is essential. Truthfulness with players. The pride, the passion, the individual responsibility, the will, the desire to work.

Eventually you build a culture. Once you get that right, as long as youve got some quality in your building, the culture is the glue that holds it all together. The way you work, the environment, then that allows the talent of the individual to flourish.

You need a lot of people with you, carrying that same message. Its very difficult to do it on your own. Theres a lot of convincing, a lot of cajoling. Then you get this flow and it starts spreading, and it spreads through your staff into the players, and into the feel of a club. But it takes time.

Time, though, is footballs most precious commodity. Blink and you miss the tweak to that rule, the latest signing at one club, the firing and hiring at another.

Yet football, Dyche says, is changing in other ways, too. A life in football is no longer shut off from those kids who love the game but are not great at playing it. It used to be that those who tried to work in football and had not played were sneered at or ignored. That has slowly changed.

Jose Mourinho is the most successful example: Sir Bobby Robsons interpreter to assistant at Barcelona, to one of the games leading managers. Dyche cites others.

Brendan Rodgers had been in the system at Reading, he got injured, was out of the game at 19, but he had a feel of it. Mark Warburton was an apprentice footballer, didnt make it as a pro, played a bit of non-league.

The open mindedness of the way coaching works now is that you can learn skillsets and still be very successful. Jose is definitely an example of that, as is Gerard Houllier, Arsene Wenger. There are many more who have come through different pathways. Its forever opening. They were some who have opened the minds of many and that continues. The world is changing in professional sport.

Dyche could end up supporting that next coach, sporting director or football leader who never played the game. He launched his familys scholarship after consulting with his son and daughter Max, 17, and Alicia, 15 and his wife Jane. They were all behind it. Jane completed a degree in business and Alicia looks to be heading down an educational path. Max is a promising footballer.

I did a bit of thinking as a dad and wanted to support someone on their journey to doing well in life, possibly someone not finding it easy to get that support, he says.

His own journey is far from over and exciting adventures lie ahead. Burnley are set for a change of ownership, with multiple parties tabling offers, meaning funds will be available for Dyche to push on. But is it even possible to take Burnley to the next level, in this world of footballs global behemoths?

There are possibilities and probabilities, Dyche begins.

Deep breath, as we plunge down another Dyche waterfall: Probably, without a financial shift, then its very difficult to compete beyond the reality of competing to be in the Premier League. Thats a probability.

Possibilities, thats a different ball game. We finished seventh. Then we finished 10th. Two out of the last three seasons. Nobody wouldve given us a chance of that. Things are achievable in a possible mindset for different things, but you have to sometimes register the probabilities. Probably life at Burnley is going to be working hard to be in the Premier League and trying to inch away at things, rather than make big strides forward at any given time. Because when you get to a certain level, finance becomes really important.

Thats something Burnley has lagged behind the truth of the market in, weve got to stretch that going forward, stretch the mentality of investment to allow Burnley to continue growing on the pitch. There are a lot of good things going on off the pitch, but they will only work if the team is working and the team will need an ongoing investment platform to take it further.

We resurface for air. Dyche looks and sounds as though he could carry on forever.

View post:
The world according to Sean Dyche: Im not always right only 99.9999 per cent of the time - iNews

Deta Hedman will make her PDC World Championship debut at the age of 61 after a superb display at the PDC Women's Series.

Hedman is seen as one of the leading pioneers in Women's Darts with 'The Heart of Darts' despite never winning the BDO World Championship, one of the most successful of all time.

She will now take on Andy Boulton at the Alexandra Palace with a rapturous reception likely for the former two time World Master.

So what is the secret to the longevity of Hedman? She believes that it is still having the enjoyment for the game and believes she will be involved as long as is possible.

"I think it's having the love and enjoyment that I still do when I play and meeting up with some great friends," she said to Sky Sports.

"I'll just see where it takes me. I will probably always be involved in the game until I drop or when my memory fails me but I'm still loving it. I have my moments!"

In terms of the future of the ladies game, Hedman believes that if given the opportunity, the glass ceiling can firmly be smashed.

"You have Mikuru [Suzuki], Lisa and Fallon who have taken the game to another level. You have another young lady called Beau Greaves who I think is going to be phenomenal.

"If the opportunity is there like the men's in the PDC then I think you will see the ladies game change again. The standard will be so high it's unbelievable. It is there. Some of the ladies do have the game and it's like any sport. It's whether you really want it."

Read the original:
Hedman on longevity ahead of World Championship debut: "I will probably always be involved in the game until I drop" - Dartsnews.com

The Navajo Nation is rolling out new coronavirus restrictions as COVID-19 cases surge and hospitals are becoming overwhelmed by an influx of patients.

Navajo Nation President Jonathan Nez on Thursday announced an extension of a lockdown order that requires all residents to stay at home and on the reservation unless obtaining essential food, medication and other supplies, as well as exemptions for essential workers.

Our country is in a historic fight against the Coronavirus. Add Changing America to your Facebook or Twitter feed to stay on top of the news.

Residents have been advised against gathering with people from outside their immediate household and to wear a mask in public.

The lockdown was initially expected to expire on Sunday but has been extended until Dec. 27 following an alarming surge of infections. As of Friday, 17,310 cases have been reported with 663 deaths.

A 57-hour weekend curfew will also kick off at 9 p.m. on Dec. 11 and last for three weeks.

The move comes as several medical and health care workers said the Navajo Nation is in a major health care crisis and pleaded with the public to stay home and adhere to public health guidelines to slow the spread of the virus during a virtual forum hosted by Nez and Vice President Myron Lizer.

Loretta Christensen, chief medical officer for Navajo Area Indian Health Service, told officials the coronavirus situation is leading to a shortage of hospital beds, oxygen supplies and medical personnel.

We have been in a state of emergency since the pandemic began here on the Navajo Nation, but that has now elevated to a major health care crisis, Nez said.

Our health experts are now saying that the current wave or surge is far more severe and troublesome than the wave that we saw in April and May, perhaps four or five times large according to projections, he said.

Nez on Thursday requested the Trump administration issue a Major Disaster Declaration to free up additional infrastructural and financial resources to better equip the nation to tackle the outbreak.

The Navajo Nation and other Native American communities have been disproportionately affected by the coronavirus pandemic.

According to the Centers for Disease Control and Prevention, American Indian or Alaska Native individuals are1.8 times more likely than their white counterparts to contract the virus, four times more likely to be hospitalized and2.6 times more likely to die from the infection.

The situation in the Navajo Nation comes as the U.S. reportedmore than 210,000 cases in a single day on Thursday, the highest figure yet, and more than 2,700 COVID-19 deaths.

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Original post:
Navajo Nation facing 'major health care crisis' as outbreak worsens | TheHill - The Hill

Exercise brings countless benefits to the mind and body; namely burning fat and fortifying mental health. There is no shortage of studies that demonstrate its impact on longevity but knowing what to do and how much to do can seem bamboozling, particularly if you are starting out. Fortunately, you can add years to your lifespan without the need to invest in high-tech equipment or engaging in high-intensity exercise.

Research published in Mayo Clinic Proceedings extolls the benefits of brisk walking, suggesting that the straight-forward exercise can boost your longevity by years.

What's more, the finding was consistent across all body profiles.

The researchers monitored the walking habits and deaths of nearly 475,000 people, most of whom were in their 50s at the start of the study, and found that people who have a quicker walking pace lived longer than those who walked more slowly.

Brisk walking was defined by researchers as walking at least three miles per hour, or 100 steps a minute.

READ MORE:How to live longer: Cinnamon lowers risk of Alzheimers & heart disease to boost longevity

However, walking pace was self-reported by participants, who were asked to indicate whether they walked at a slow pace, steady/average pace, or brisk pace.

Participants with brisk walking paces had longer life expectancies across all categories of body mass index (BMI).

The BMI is a measure that uses your height and weight to work out if your weight is healthy.

"The survival is the same for fast walkers for a wide range of body mass index, from 20 to 40, Dr Francesco Zaccardi, a clinical epidemiologist at the University of Leicester in the United Kingdom and the studys lead researcher, told Healthline.

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"This result indicates that physical function is a stronger determinant of longevity than body mass index, and also people with high body mass index but with good fitness may survive longer, he said.

Conversely, participants with slower walking paces had shorter life expectancies across all categories of BMI.

Researchers reported that women who walked more quickly had a life span of about 87 years compared to 72 years for women who walked slowly.

Men who walked quickly had a life span of about 86 years compared to 65 years for men who walked more slowly.

That works out as a 15-year average difference for women and a 20-year average difference for men.

Exercise is integral to longevity because it provides a bulwark against obesity, which can usher in life-threatening diseases and conditions.

These include:

Obesity can also undermine your quality of life and lead to psychological problems, such as depression and low self-esteem.

In addition to exercising regularly, it is vital that you eat a healthy, balanced diet to tackle obesity.

According to the NHS, a healthy diet should consist of:

"Try to avoid foods containing high levels of salt because they can raise your blood pressure, which can be dangerous for people who are already obese," warns the the health body.

It adds: "You'll also need to check calorie information for each type of food and drink you consume to make sure you don't go over your daily limit."

The rest is here:
How to live longer: Brisk walking proven to boost longevity - how fast must you walk? - Express

Were all getting used to wearing masks, using hand sanitizer, and standing at least 1 meter apart. One industry that is hoping a new normal can breathe life back into their livelihoods is the world of travel.

Staycations have grown in popularity, which is great for the UK economy. But with tourism worth billions for countries across the globe, it is important that people are still able to see travelling abroad as a viable and safe option during unpredictable times.

In this article, we are going to discuss what the future of holidays may look like today, tomorrow, and in a post-pandemic world, as global economies get to grips with recovering from nearly a year of lockdowns and closures.

The safety of people is paramount when you consider how wildly the virus can spread. We have seen the devastation it can cause without the correct measures in place.

We know the ability to travel abroad hinges on the health of the passenger and the health of the country. This is because of infection rates, especially spikes that raise alarm bells for governments and medical professionals.

The UKs travel corridors are a way of working out which countries are deemed safe to travel to. Were in a situation where you could be in a country one night and everything is okay, to waking up and finding out youll need to quarantine for 14-days on your return.

Its the world we live in right now. Economies need to support each other. But, at the same time, it has to be a case of common sense over cash is king. Were likely to be in a position for quite some time when the rules change overnight. Hopefully, it doesnt completely deter people from booking holidays and visiting new places. That said, hopefully, you respect social distancing and other measures put in place by the country you call your own for a week or two.

Choosing where to stay when you go on holiday isnt just about the room youll sleep in. Food, drink, entertainment, and the fact its going to be full can play on your mind more than the thickness of the duvet.

But during and even for a short time after the global pandemic, a secluded area could be the ideal way to avoid busy pool areas and hungry holiday goers at the buffet. Villas and private apartments can offer luxury, sun, and the all-important peace of mind that youre able to spend time in a family bubble while socially distancing in the more vibrant areas of popular destinations.

Lockdown has given people more time to think and more opportunity to realize what is important for them. Weve seen the rise of home workouts with the likes of Joe Wicks, and now were potentially heading for a rise in wellness retreats, where seclusion and safety is the order of the day. Bali and China are home to some of the most beautiful wellness retreats in the world such as the Sangha Retreat in Yangcheng Island, Suzhou the perfect place to seek self-clarity and serenity. Such is the beauty of this retreat, especially that youll be Googling how to complete a Chinese visa application once you check out the website.

Its easy to speculate about the future of travelling abroad and what a post-pandemicor even a current pandemic holidaylooks like. But its important to remember that the travel, tourism, and cultural tourism industries have been hit hard by the virus. The fact a future can even be talked about is positive. However, the hope is that it doesnt just remain talk and that we continue to move forward with the new normal and the new way to go on holiday.

This is Longevity Live Partner Content

Thomas Bradley is a copywriter at Visa Genie. He has over seven years communications and copywriting experience, having previously worked in the financial services sector and car industry.

Continue reading here:
What Will the Future of Holiday Travel Look Like? - Longevity LIVE - Longevity LIVE

LAKE HIAWATHA, NJ - GladysHess, resident of Lake Hiawatha, NJ for more than 25years, will be turning 101 on December 28.

Gladyswas born andraised in New Jersey. She is mother to seven children andcountless grandchildren andgreat-grandchildren.

Gladysnever got her drivers license, andhas navigatedher way around New Jersey andNew York by walking andcatching the local buses. She recentlyretireda few years ago, but still remainsactive - enjoying walks andtraveling.

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Her family andfriends describe her as kind, funny, anddetermined. They also say she has the most interesting stories around- from lunching with Frank Sinatra, to seeing towns transition from gas to electricity, andthe rapid growth of technology (she has a cell phone!)

Two of her many secrets for looking andfeeling good are black coffee andred wine.

View post:
NJ Resident Turning 101 Credits Longevity to Red Wine and Black Coffee - TAPinto.net

Speaking frankly to married clients about the implications of survivorship is a critical service that financial advisors not only can and should provide but also are uniquely suited to address.

Given womens longer life spans and the fact that women in opposite-sex marriages tend to marry men who are older than they are, women often must be prepared to cover their expenses single-handedly for years after their husbands die. Compounding the problem, widowhood will likely occur during a phase of life when health care expenses will be at their highest.

The financial and longevity disparities between women and men create a unique challenge. In our white paper Addressing The Womens Longevity Gap we discuss the challenges women face in retirement, largely stemming from lower working salaries and greater longevity relative to men, making the threat of poverty quite real for millions of women.

Financial advisors have an opportunity to help married men and women plan strategically for the womens longevity gap. A prepared advisor can help women mitigate and potentially even eliminate the unique financial challenges of the longevity gap by taking the following steps:

Make financial plans based on personalized data and actuarial longevity.

Address retirement health care costs today.

Start Social Security optimization planning today (with a focus on survivor benefits).

Discuss finances, including Medicare surcharges, for the surviving spouse.

Plan for end-of-life costs for both partners.

On average, a healthy 65-year-old woman is expected to live to age 89, compared to age 87 for a healthy 65-year-old man, according to actuarial data. Compounding this longevity gap, women tend to marry men two years older than they are, stretching the average length of widowhood by four years or more.

HealthView Services data indicates that a given client might live much longer or much shorter than the average, largely depending on how well or how poorly their health conditions are managed as they age.

Relevant, personalized data and actuarial longevity figures can help advisors pinpoint specific future costs, such as health care expenses. With this information, advisors can develop retirement income plans that are appropriate for their clients expected life spans and avoid overly conservative plans that unnecessarily restrict spending.

Three in five women age 60 and over say they are worried that their health care costs will exceed their retirement income, the National Council on Aging reported. On average, women pay more than men do for health care in retirement, primarily due to womens longer life spans rather than increased use of medical services.

When comparing projected retirement health care costs between a healthy 45-year-old man and his 43-year-old wife, her costs are projected to be about $200,000 more. While that is a large sum, she can fund that amount by investing just $8,000 more today, assuming an investment in a balanced portfolio of 60% stocks and 40% bonds with an average annual return of 6%.

This example demonstrates the value advisors can provide by tackling retirement planning early with couples. The notable lifetime cost increases women face can be offset more easily with early planning for investments and insurance products. Advisors can sharpen the efficacy of these plans by using reliable, personalized actuarial health care cost projections.

Designed to replace 40% of preretirement earnings, Social Security benefits never expire. As a result, women on average collect more years of benefits than men do, but a couples decisions about Social Security will have a major impact on benefit calculations and the wifes income during the longevity gap.

Social Securitys benefit calculations are based on a complex formula that tracks past earnings. Women tend to have lower earnings over their lifetimes due to their pay inequality as well as time spent out of the workforce caregiving for children, parents and spouses. Lower earnings produce a lower primary insurance amount, which is the starting point for all Social Security benefit calculations.

The following strategies can help female clients maximize the stream of income they receive from Social Security.

Delay retirement. Social Security benefits are based on the highest 35 years of Social Security-taxed earnings. Filling as many of those years as possible with employment is beneficial, especially with late-career, high-income years.

Delay Social Security filing age. Claiming benefits at 62, the earliest possible age, permanently reduces an individuals retirement benefits, and yet it is the choice made by about one-third of women. Delaying benefits, especially if still working, ensures that women earn a higher income later.

Optimize Social Security from a household benefit perspective, including survivor benefits. Advisors should help couples maximize household income rather than looking at each spouse separately. Since many women will outlive their husbands, this approach is particularly important. For example, benefits for a man (Paul) who claims Social Security at 70 instead of at 62 will be 76% higher during his lifetime. After his death, his wifes (Judy) survivor benefit would be 60% higher a meaningful increase. As the lower-wage earner, a woman who is eligible for Social Security benefits may begin collecting her husbands benefits and forgo her own, which are likely to be lower for reasons stated earlier.

Plan for benefits from former spouses. Women (and men) may be eligible to collect survivor benefits from a former spouse if they meet certain criteria. Making them aware of all of their claiming options can help maximize the benefits they ultimately receive.

Although Social Security is meant to replace 40% of preretirement income, other savings and investments comprise the remaining income stream and support a consistent standard of living. The sources that fuel retirement income are not treated consistently from either a tax perspective or by Medicare, making this another area where financial advisors have a real opportunity to shine for clients.

Known as means testing, Medicares Income-Related Monthly Adjustment Amount determines the surcharges paid for Medicare Parts B and D. These surcharges vary by income and marital status. But when one spouse dies, the survivors income threshold is reduced by 50%, despite the fact that many may reduce their household income by only 20% after the passing of a spouse. As a result, women may be pushed into higher surcharge brackets, potentially resulting in tens of thousands of dollars of additional costs.

A financial advisor could address this challenge well before it comes up, with the understanding that Medicare measures ones means by modified adjusted gross income. Some forms of income, such as required 401(k) distributions, do count as MAGI; and other forms, such as health savings accounts, life insurance, annuities and Roth IRAs, do not. Therefore, advisors have a significant opportunity to help clients build a balanced portfolio of savings and retirement income vehicles that will limit taxes as well as substantial Medicare surcharges.

Death can come very quickly, or it can be a slow, debilitating and expensive decline, but its an eventuality for all. Being prepared for significant end-of-life care expenses is not something couples will ever regret. Savvy financial advisors can help client couples plan years before retirement for the cost of end-of-life care.

In 20 years, a year of nursing home care is expected to cost $175,000, while a year of assisted living would run $100,000, with dramatic regional variations in costs. This consideration is crucial for women, who, on average, spend about two-and-a-half years in long-term care facilities at the end of life. Thats a full year longer than what the average man experiences because he has his wife to care for him.

Accurately planning for a mans end-of-life care costs is critical to his widows ongoing financial security. But planning for her end-of-life care costs is critical to her experience. It will define whether she has suitable care options for her final years or ends up dependent on state support or her children.

Whether couples choose to buy long-term care coverage or free up additional cash to invest, or both, the steps they take now can help fill the womens longevity gap with financial security.

Understanding their personal health outlook can help guide savings amounts and selection of the most advantaged vehicles to ensure a financially secure retirement and the ability to manage future health care costs without dramatic reductions to the couples hoped-for standard of living.

As their trusted advisor in these sensitive, important areas, you will earn their confidence, trust and referrals. And you will give your clients the invaluable: genuine peace of mind as they age.

Originally posted here:
Take Steps To Bridge The Women's Longevity Gap - Insurance News Net

New Jersey, United States: Market Research Intellect has added a new report to its huge database of research reports, entitled Longevity and Anti-senescence Therapy Market Size and Forecast to 2027. The report offers a comprehensive assessment of the market including insights, historical data, facts, and industry-validated market data. It also covers the projections using appropriate approximations and methods.

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The Longevity and Anti-senescence Therapy Market Report provides comprehensive data on market dynamics, market trends, product growth rate, and price. The Longevity and Anti-senescence Therapy market report has various facts and statistics assuming the future predictions of the upcoming market participants. In addition, it offers business security taking into account sales, profit, market volume, demand and market supply ratio. The in-depth study provides vital information related to market growth, driving factors, major challenges, opportunities, and threats that will prove to be very helpful for market participants in making upcoming decisions.

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The Longevity and Anti-senescence Therapy Market report consists of the Competitive Landscape section which provides a complete and in-depth analysis of current market trends, changing technologies, and enhancements that are of value to companies competing in the market. The report provides an overview of sales, demand, futuristic costs and data supply as well as a growth analysis in the forecast year. The key vendors in the market that are performing the analysis are also clearly presented in the report. Their development plans, their growth approaches, and their merger and acquisition plans are also identified. Information specific to a keyword in each of these regions is also provided. This report also discusses the submarkets of these regions and their growth prospects.

Prominent players operating in the market:

Longevity and Anti-senescence Therapy Market Segmentation

The report contains the market size with 2019 as the base year and an annual forecast up to 2027 in terms of sales (in million USD). For the forecast period mentioned above, estimates for all segments including type and application have been presented on a regional basis. We implemented a combination of top-down and bottom-up approaches to market size and analyzed key regional markets, dynamics and trends for different applications.

Longevity and Anti-senescence Therapy Market Segment by Type:

Longevity and Anti-senescence Therapy Market Segment by Application:

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In the report, experts analyze and forecast the Longevity and Anti-senescence Therapy market on a global as well as regional level. Taking into account all aspects of the market in terms of regions, the focus of the report is on North America, Europe, Asia Pacific, the Middle East and Africa, and South America. The prevailing trends and various opportunities in these regions are studied that can convince the growth of the market in the forecast period 2020 to 2027.

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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

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Market Research Intellect

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Tel: +1-650-781-4080

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Longevity and Anti-senescence Therapy Market Size, Revenue, Share, Scope, Growth Rate And Forecast To 2027 - Cheshire Media

The Aerobics Centre Longitudinal Study, published in Medicine and Science in Sports and Exercise, analysed nearly 13,000 adults.

Three health outcomes were measures - cardiovascular events such as heart and stroke that didnt result in death, all cardiovascular events including death and any type of death.

DC Lee, associate professor of kinesiology, said resistance exercise reduced the risk of all three.

The results are encouraging, but will people make weightlifting part of their lifestyle? Will they do it and stick with it? That's the million-dollar question, he said.

READ MORE:New long-Covid symptom: Coronavirus may cause sufferers teeth to fall out, say dentists

A lot of research on strength training has focused on bone health, physical function and quality of life in older adults.

When it comes to reducing the risk for cardiovascular disease, most people think of running or other cardio activity.

But Less said weight lifting is just as good for your heart, and there are other benefits to be had.

Lee and his colleagues also looked at the relationship between resistance exercise and diabetes, as well as high cholesterol.

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The two studies, published in Mayo Clinic Proceedings, found resistance exercise lowered the risk of both.

Less than an hour of weekly resistance exercise, when compared with no resistance exercise, was associated with a 29 percent lower risk of developing metabolic syndrome - a condition which increases the risk of heart disease, stroke and diabetes.

The risk of high cholesterol was 32 percent lower.

The results for both studies were also independent of aerobic exercise.

"Muscle is the power plant to burn calories. Building muscle helps move your joints and bones, but also there are metabolic benefits. I don't think this is well appreciated," said Lee.

If you build muscle, even if you're not aerobically active, you burn more energy because you have more muscle.

This also helps prevent obesity and provide long-term benefits on various health outcomes."

Weekly resistance exercise is recommended by the NHS.

As part of its physical activity guidelines for adults aged 19 to 64 it advises adults aim to do strengthening activities that work all the major muscles (legs, hips, back, abdomen, chest, shoulders and arms) on at least two days a week.

Adults are also advised to aim to do at least 150 minutes of moderate intensity activity a week or 75 minutes of vigorous intensity activity a week.

You should aim to be physically active every day - any activity is better than none.

And you should reduce time spent sitting or lying down, and break up long periods of not moving with some activity.

See more here:
How to live longer: Lifting weights for less than an hour a week could boost longevity - Express

We have been told about the importance of protecting gut health as a measure to take care of overall health. Do you know what probiotics are and what are they for? These live bacterial cultures have become one of the best allies to protect intestinal health. Any gut doctor can advise you on their importance.

They are critical to the synthesis of some essential nutrients and to maintain optimal digestive health. Likewise, they create a protective barrier against infections and act beneficially on some inflammatory processes. Although they exist naturally in the body, they can be consumed through some fermented or dairy foods as well as food supplements. You should look for the best probiotic supplements that will keep your gut in perfect shape.

Probiotics are good bacteria and yeasts. They survive passage through the gastrointestinal tract to implant in the colon and small intestine. Although many associate bacteria with the disease, their role is very different.

Probiotics can stop the excessive growth of infectious microorganisms. Therefore, they are key to preventing the development of various pathogens. Those most used for human benefit are lactobacilli and bifidobacteria.

To sum it up, these non-harmful bacteria and yeasts occupy sites where pathogenic microorganisms could implant. By not leaving room for them and favoring some processes such as digestion, they are beneficial.

The gastrointestinal tract is packed with about 400 bacterial species. Among its primary functions is to protect the body against the proliferation of pathogens responsible for many conditions.

They are also responsible for controlling the differentiation of epithelial cells. They are also involved in metabolic processes and the production of vitamins. Therefore, it is essential to have a balanced intestinal flora rich in healthy bacteria.

Probiotics are the best alternative to improve gut health. Here are the benefits of probiotics.

There is nothing worse than having diarrhea. If youre suffering from diarrhea caused by an infection, probiotics can help you heal faster and lessen the severity of your symptoms. It will get rid of all the elements that bring about stomach pain. Using it will not affect some of the good bacteria in your gut.

Are you taking antibiotics? Probiotics can help rebalance your gut. Taking antibiotics kills the harmful bacteria that are causing your infection. However, it can also kill the good bacteria in your gut, leading to diarrhea in some people. Probiotics can play a pivotal role in replenishing some of the good bacteria destroyed by the drugs.

Irritable Bowel Syndrome is a condition affecting the stomach. It causes severe pain and problems, including constipation, diarrhea, or a combination of the two. It is a syndrome that affects around 10% to 15% of the population. Research shows that bacteria can play an essential role in this syndrome. Probiotics have shown promise in improving IBS symptoms, especially in people who experience diarrhea more often.

Are you going on a trip? Consider bringing probiotics. We all want to focus on the fun things to do, local food, and sightseeing while on vacation. That said, theres nothing worse than having your trip ruined by an unexpected episode of tourista. Fortunately, probiotics containing specific strains of bacteria and yeast have shown promise in this regard. If you plan on taking a probiotic while traveling, remember to choose one that doesnt need to be refrigerated. Ask your pharmacist to help you select a product if in doubt.

Different types of probiotics have other health effects. Many of the effects of probiotics take place via multiple actions of these on the gut flora:

Now that we know what probiotics are for, it is good to know their sources. Here are some of its sources.

Fermented foods contain probiotics. The most popular include:

Not all people get enough probiotics through diet. Considering their importance for health, the option of including them in supplements is an excellent idea. Supplements are available in capsules, powders, and other similar products. These contain large concentrations of microorganisms, beneficial, and protective of health.

Some presentations are enriched with prebiotics, which are foods that promote the growth of these good bacteria. Therefore, in many cases, these products are more effective than the probiotics that come from the traditional diet. In other words, a prebiotic food is one that favors the growth of beneficial microorganisms. And a probiotic is one that directly contains those healthy beings.

Bowel balance is good for your general health. We are learning a lot of things about probiotics every day, and the proof for their benefits keeps growing. If you want to add probiotics to your life, talk to a qualified pharmacist or healthcare professional. They will help choose the product thats best for you.

The gut is regularly referred to as the second brain because the gut microbiome can have a big impact on your body, including the state of your hair. That said, the gut microbiome can be affected by your lifestyle choices and anything that throws it off balance can compromise your health, as well asaffect the health of your locks. So, heres how a healthy gut can help prevent hair loss.

Read more:
5 Benefits of Probiotics for Gut Health - Longevity LIVE - Longevity LIVE

Market Expertz latest study, titled Global Longevity and Anti-senescence Therapy Market, sheds light on the crucial aspects of the global Longevity and Anti-senescence Therapy market. The report aims to help readers accurately estimate the global market growth rate over the forecast period (2020-2027). Our market research team has meticulously performed quantitative and qualitative assessments of the Longevity and Anti-senescence Therapy market dynamics, considering a slew of factors, including market penetration, product portfolios, end-user industries, pricing structure, and the key drivers, constraints, opportunities, and challenges predominantly affecting market growth.

The latest market study broadly segments the industry based on the product type range, application gamut, end-use industry, key regions, and the competitive background. One of the central components of the report is a detailed explanation of the gross profits, revenue shares, sales volume, manufacturing costs, individual growth rate, and the financial standing of the leading market players. The developmental scope of the Longevity and Anti-senescence Therapy markets new entrants and established companies has also been emphasized in the report.

Request a sample copy of the report to understand the structure of the complete [emailprotected] https://www.marketexpertz.com/sample-enquiry-form/97708

Competitive Terrain:

The global Longevity and Anti-senescence Therapy market is highly consolidated due to the presence of numerous companies operating across this industry. The report depicts the current market standing of these companies, their past performances, demand and supply graphs, production and consumption patterns, sales network, distribution channels, and growth opportunities in the market. The leading market contenders listed in the report are:

Market segments by Top Manufacturers:

CohBarTA SciencesUnity BiotechnologyAgeX Therapeutics?IncPowerVision Inc.

The latest report is inclusive of an extensive coverage of the significant impact of the COVID-19 pandemic on the Longevity and Anti-senescence Therapy business sector. The coronavirus outbreak has drastically impacted the global economic landscape, and consequently, this particular business vertical. Therefore, the report provides the reader with a clear concept of the current scenario of this business vertical, estimating its COVID-19 aftereffects.

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Product Type SegmentationHemolytic Drug TherapyGene TherapyImmunotherapyOther Stem Cell Therapies

Industry SegmentationHospitalMedical Service InstitutionDrug and Device Sales

Geographical Scenario:

In this section of the report, market analysts have provided valuable insights into the geographical segmentation of the Longevity and Anti-senescence Therapy market. They have further estimated the current and future market valuations on the basis of the demand-supply dynamics and pricing structure of the leading regional segments. Moreover, the growth prospects of each regional segment have been meticulously extensively discussed in the report.

The global Longevity and Anti-senescence Therapy market is classified into the following regions:

Browse the full report description, along with the ToCs and List of Facts and Figures @ https://www.marketexpertz.com/industry-overview/global-2020-longevity-and-anti-senescence-therapy-market

Highlights of the Table of Contents:

1.1 Research Scope

1.2 Key Longevity and Anti-senescence Therapy market segments

1.3 Target players

1.4 Market analysis by type

1.5 Market analysis by application

1.6 Key learning objectives

1.7 Report timeline

2.1 Global Longevity and Anti-senescence Therapy market size

2.2 Latest trends of the Longevity and Anti-senescence Therapy market by region

2.3 Key corporate trends

3.1 Global Longevity and Anti-senescence Therapy size by manufacturers

3.2 Global Longevity and Anti-senescence Therapy market key players

3.3 Products/solutions/services of major players

3.4 New entrants in the Longevity and Anti-senescence Therapy market

3.5 Mergers, acquisitions, joint ventures, and expansion plans

4.1 Global Longevity and Anti-senescence Therapy Sales by Product

4.2 Global Longevity and Anti-senescence Therapy by Product Revenue

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Longevity and Anti-senescence Therapy Market Growth and Current Status of Industry Surveyed in New Research Report | (2020-2027) - The...