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Archive for the ‘Longevity Genetics’ Category

Dr. William Kelley inducted into IAOTPs Hall of Fame – PRUnderground

Monday, February 1st, 2021

Dr. William N. Kelley, MACP, MACR, Professor of Medicine at the University of Pennsylvania, was recently inducted into the International Association of Top Professionals (IAOTP) Hall of Fame.

Being selected by the International Association of Top Professionals is an esteemed honor, as only 20 IAOTP members are inducted each year into the exclusive Hall of Fame. These special honorees are distinguished by their longevity in their fields, the contributions they have made to society, and the impact they have had on their industries.

With over five decades of professional experience as an Educator, Physician Scientist, and Medical Doctor, Dr. Kelley has undoubtedly proven himself an extraordinary professional and an expert in medical research and education. Dr. Kelley is a dynamic, results-driven leader who has demonstrated success as one of the most respected doctors in America. In the early 1990s at PENN, Dr. Kelley, in his role as Dean of the Medical School and CEO of the Health System (the combination now known as PENN Medicine), began to build a broad research program focused on the creation of gene-based medicine and vaccines as a new method for preventing and curing human disease. While the road was a rocky one over the last three decades, he is proud to note that PENN Medicine is now the global leader in this new field. This includes the two recently FDA approved mRNA vaccines (Moderna and Biontech/Pfizer) to prevent COVID-19 which came from the PENN Medicine research laboratories of Doctors Katalin Kariko and Drew Weissman. He is noted for developing the first fully integrated university-based academic health system in the country at the University of Pennsylvania and expanding the Medical Centers regional footprint by acquiring hospitals and private practices, including Pennsylvania Hospital and Penn Presbyterian Medical Center. Dr. Kelleys impressive repertoire of roles has included Dean of the Perelman School of Medicine, CEO of the University of Pennsylvania Medical Center, and Founding CEO of the Penn Health System (now known as Penn Medicine).

Prior appointments included Professor of Medicine, Associate Professor of Biochemistry, and Chief of Rheumatic and Genetic Diseases at Duke University, followed by Professor of Biological Chemistry and Internal Medicine, and Chair of Internal Medicine with the Medical School at the University of Michigan in Ann Arbor.

Dr. Kelley was known for his breakthrough research and leadership of academic medical programs at Duke and the University of Michigan when he arrived at Penn. During Dr. Kelleys Tenure, the Perelman School became a research powerhouse moving the school into the top 3 rankings for NIH funding. There is now a Professorship named in his honor at the Perelman School of Medicine.

Dr. Kelley earned his Doctor of Medicine at Emory University in Atlanta, GA, in 1963 and subsequently served an internship and residency in Medicine at the Parkland Memorial Hospital in Dallas, TX. He completed his senior residency in Medicine at Massachusetts General Hospital in Boston. Dr. Kelleys other titles have included Clinical Associate in Human Biochemical Genetics with the National Institutes of Health, Educator to Fellow of Medicine at Harvard University, and Macy Faculty scholar at the University of Oxford in England. Later in his career, he received an honorary Master of Arts from the University of Pennsylvania.

The President of IAOTP, Stephanie Cirami, stated, Inducting Dr. Kelley into our Hall of Fame was an effortless decision for our panel to make. In addition to his long list of accomplishments and accolades, he is well regarded and well recognized in academic medicine. We are thrilled to honor him in this way and look forward to celebrating his success with him.

Throughout his illustrious career, Dr. Kelley has received many awards, accolades and has been recognized worldwide for his outstanding leadership and commitment to the profession. He will be honored at IAOTPs 2021 Annual Awards Gala, being held at the Plaza Hotel in NYC for his selection as Top Professor of the Year in Medicine for 2020; he will be inducted on stage at the ceremony for his appointment into the Hall of Fame. In 2018 he received the Albert Nelson Marquis Lifetime Achievement Award. In 2005, Dr. Kelley was presented with the Kober Medal by the Association of American Physicians and the Emory Medal in 2000 from his alma mater, Emory University. He was the recipient of the David E. Rogers Award from the Association of American Medical Colleges, the John Phillips Award of the American College of Physicians, the Gold Medal Award from the American College of Rheumatology, the Robert H. Williams Award from the Alliance for Academic Internal Medicine, and the National Medical Research Award from the National Health Council. Dr. Kelley has been featured in many magazines and publications, including Whos Who in America, Whos Who in Medicine and Healthcare, and Whos Who in the World.

Aside from his successful career, Dr. Kelley is a sought-after lecturer, speaker, and contributor to numerous professional journals and chapters to books. He was the co-inventor of a Viral-Mediated Gene Transfer System, now the most commonly used method today for in vivo gene therapy. Dr. Kelley founded and edited numerous early editions of Kelley and Firesteins Textbook of Rheumatology and Kelleys Textbook of Internal Medicine. He was also editor-in-chief for Essentials of Internal Medicine and co-editor of Arthritis Surgery and Emerging Policies for Bio-Medical Research. Dr. Kelley has served on the Board of Directors for many public companies such as Beckman Coulter, Inc. and Merck & Co., Inc, and has been involved with many committees and subcommittees with the National Institutes of Health. He is a member of the National Academy of Medicine, The American Academy of Arts & Sciences, and the American Philosophical Society.

Looking back, Dr. Kelley attributes his success to his perseverance, his education, his mentors as well as outstanding students and trainees he has had along the way. When not working, he enjoys traveling and spending time with his family. For the future, he hopes that his contributions will continue to improve human health worldwide.

For more information on Dr. Kelley please visit: http://www.iaotp.com

Watch his video: https://www.youtube.com/watch?v=6uhxBnYVY54

About IAOTP

The International Association of Top Professionals (IAOTP) is an international boutique networking organization that handpicks the worlds finest, most prestigious top professionals from different industries. These top professionals are given an opportunity to collaborate, share their ideas, be keynote speakers, and to help influence others in their fields. This organization is not a membership that anyone can join. You have to be asked by the President or be nominated by a distinguished honorary member after a brief interview.

IAOTPs experts have given thousands of top prestigious professionals around the world, the recognition and credibility that they deserve andhave helped in building their branding empires.IAOTP prides itself to bea one of a kind boutique networking organization that hand picks only the best of the best and creates a networking platform that connects and brings these top professionals to one place.

For More information on IAOTP please visit: http://www.iaotp.com

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Baptist Health of Northeast Florida Joins Forces with Blue Zones to Begin Building a Plan for Well-Being Transformation in Jacksonville – PR Web

Monday, February 1st, 2021

Baptist Healths vision is A Lifetime of Health, Together. That vision extends beyond the walls of our hospitals and calls us to help all people in the community live longer and healthier lives. -- Brett McClung, President and CEO of Baptist Health

MINNEAPOLIS (PRWEB) January 26, 2021

Baptist Health has invited Blue Zones to bring its expertise in well-being innovation to Jacksonville. The first phase is a Blue Zones Activate assessment and feasibility study that will help determine how to make Jacksonville a healthier and happier place to live, work, and grow old.

Research shows that where people live has a significant influence on their health even more than their genetics. Blue Zones tackles this "zip code effect" by using scientifically proven lessons of longevity, health, and happiness gleaned from their 20 years of international research to boost the well-being of entire communities.

By focusing on making permanent and semi-permanent changes to the Life Radius--the area close to home where people spend 90% of their lives--Blue Zones has helped hundreds of communities achieve measurable improvements in its residents health.

Baptist Healths vision is A Lifetime of Health, Together, said Brett McClung, President and CEO of Baptist Health. That vision extends beyond the walls of our hospitals and calls us to help all people in the community live longer and healthier lives. We are excited to build on a long legacy of community partnership by inviting Blue Zones, a proven leader in community-led health improvement, to help Jacksonville learn some new and innovative ways to achieve transformational results.

In the midst of the COVID-19 pandemic, this work begins at a time when public focus is now, more than ever, on the interconnectedness of our health to that of our friends and neighbors. As a proven and comprehensive solution influencing social determinants of health and improving health equity, the Blue Zones approach for strengthening community well-being will be critical as we navigate recovery.

In the assessment phase, which begins in January and concludes with recommendations in May, Blue Zones collaborates with local leaders to assess readiness and build a plan for change. The Blue Zones team, made up of global experts in food systems, the built environment, tobacco and alcohol use, health equity, and happiness, will work with local experts and leaders to assess the highest priority needs and opportunities, as well as strengths and challenges.

Ben Leedle, CEO of Blue Zones said, We are excited to learn from and share our knowledge with Jacksonville leaders, and we applaud Baptist Health for spearheading this movement. Improved well-being leads to healthier and happier residents, a better and more productive workforce, and a more vibrant economy. We are excited to create a transformation plan for Jacksonville that will improve the lives of current and future generations.

For more information on Blue Zones Activate or to learn how to get involved, visit bluezones.com/activate-jacksonville.

About Blue Zones Blue Zones employs evidence-based ways to help people live longer, better. The companys work is rooted in explorations and research done by National Geographic Fellow Dan Buettner in Blue Zones regions around the world, where people live extraordinarily long and/or happy lives. The original research and findings were released in Buettner's bestselling books The Blue Zones Solution, The Blue Zones of Happiness, The Blue Zones, Thrive, and Blue Zones Kitchenall published by National Geographic books. Using original Blue Zones research, Blue Zones works with cities and counties to make healthy choices easier through permanent and semi-permanent changes to our human-made surroundings. Participating communities have experienced double-digit drops in obesity and tobacco use and have saved millions of dollars in healthcare costs. For more information, visit bluezones.com.

About Baptist Health Baptist Health is a faith-based, mission-driven system in Northeast Florida comprised of Baptist Medical Center Jacksonville; Baptist Medical Center Beaches; Baptist Medical Center Nassau; Baptist Medical Center South; Baptist Clay Medical Campus and Wolfson Childrens Hospital the regions only childrens hospital. All Baptist Health hospitals, along with Baptist Home Health Care, have achieved Magnet status for excellence in patient care. Baptist Health is part of Coastal Community Health, a highly integrated regional hospital network focused on significant initiatives designed to enhance the quality and value of care provided to our contiguous communities. Baptist Health has the areas only dedicated heart hospital; orthopedic institute; womens services; neurological institute, including comprehensive neurosurgical services, a comprehensive stroke center and two primary stroke centers; a Bariatric Center of Excellence; a full range of psychology and psychiatry services; urgent care services; and primary and specialty care physicians offices throughout Northeast Florida. The Baptist MD Anderson Cancer Center is a regional destination for multidisciplinary cancer care, which is clinically integrated with the MD Anderson Cancer Center, the internationally renowned cancer treatment and research institution in Houston. For more details, visit baptistjax.com.

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Is longevity determined by genetics?: MedlinePlus Genetics

Monday, January 25th, 2021

The duration of human life (longevity) is influenced by genetics, the environment, and lifestyle. Environmental improvements beginning in the 1900s extended the average life span dramatically with significant improvements in the availability of food and clean water, better housing and living conditions, reduced exposure to infectious diseases, and access to medical care. Most significant were public health advances that reduced premature death by decreasing the risk of infant mortality, increasing the chances of surviving childhood, and avoiding infection and communicable disease. Now people in the United States live about 80 years on average, but some individuals survive for much longer.

Scientists are studying people in their nineties (called nonagenarians) and hundreds (called centenarians, including semi-supercentenarians of ages 105-109 years and supercentenarians, ages 110+) to determine what contributes to their long lives. They have found that long-lived individuals have little in common with one another in education, income, or profession. The similarities they do share, however, reflect their lifestylesmany are nonsmokers, are not obese, and cope well with stress. Also, most are women. Because of their healthy habits, these older adults are less likely to develop age-related chronic diseases, such as high blood pressure, heart disease, cancer, and diabetes, than their same-age peers.

The siblings and children (collectively called first-degree relatives) of long-lived individuals are more likely to remain healthy longer and to live to an older age than their peers. People with centenarian parents are less likely at age 70 to have the age-related diseases that are common among older adults. The brothers and sisters of centenarians typically have long lives, and if they develop age-related diseases (such as high blood pressure, heart disease, cancer, or type 2 diabetes), these diseases appear later than they do in the general population. Longer life spans tend to run in families, which suggests that shared genetics, lifestyle, or both play an important role in determining longevity.

The study of longevity genes is a developing science. It is estimated that about 25 percent of the variation in human life span is determined by genetics, but which genes, and how they contribute to longevity, are not well understood. A few of the common variations (called polymorphisms) associated with long life spans are found in the APOE, FOXO3, and CETP genes, but they are not found in all individuals with exceptional longevity. It is likely that variants in multiple genes, some of which are unidentified, act together to contribute to a long life.

Whole genome sequencing studies of supercentenarians have identified the same gene variants that increase disease risk in people who have average life spans. The supercentenarians, however, also have many other newly identified gene variants that possibly promote longevity. Scientists speculate that for the first seven or eight decades, lifestyle is a stronger determinant of health and life span than genetics. Eating well, not drinking too much alcohol, avoiding tobacco, and staying physically active enable some individuals to attain a healthy old age; genetics then appears to play a progressively important role in keeping individuals healthy as they age into their eighties and beyond. Many nonagenarians and centenarians are able to live independently and avoid age-related diseases until the very last years of their lives.

Some of the gene variants that contribute to a long life are involved with the basic maintenance and function of the bodys cells. These cellular functions include DNA repair, maintenance of the ends of chromosomes (regions called telomeres), and protection of cells from damage caused by unstable oxygen-containing molecules (free radicals). Other genes that are associated with blood fat (lipid) levels, inflammation, and the cardiovascular and immune systems contribute significantly to longevity because they reduce the risk of heart disease (the main cause of death in older people), stroke, and insulin resistance.

In addition to studying the very old in the United States, scientists are also studying a handful of communities in other parts of the world where people often live into their nineties and olderOkinawa (Japan), Ikaria (Greece), and Sardinia (Italy). These three regions are similar in that they are relatively isolated from the broader population in their countries, are lower income, have little industrialization, and tend to follow a traditional (non-Western) lifestyle. Unlike other populations of the very old, the centenarians on Sardinia include a significant proportion of men. Researchers are studying whether hormones, sex-specific genes, or other factors may contribute to longer lives among men as well as women on this island.

Martin GM, Bergman A, Barzilai N. Genetic determinants of human health span and life span: progress and new opportunities. PLoS Genet. 2007 Jul;3(7):e125. PubMed: 17677003. Free full-text available from PubMed Central: PMC1934400.

Sebastiani P, Gurinovich A, Bae H, Andersen S, Malovini A, Atzmon G, Villa F, Kraja AT, Ben-Avraham D, Barzilai N, Puca A, Perls TT. Four genome-wide association studies identify new extreme longevity variants. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1453-1464. doi: 10.1093/gerona/glx027. PubMed: 28329165.

Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012;7(1):e29848. doi: 10.1371/journal.pone.0029848. Epub 2012 Jan 18. PubMed: 22279548. Free full-text available from PubMed Central: PMC3261167.

Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 Feb 15;9(377). pii: eaai8700. doi: 10.1126/scitranslmed.aai8700. PubMed: 28202779.

Young RD. Validated living worldwide supercentenarians, living and recently deceased: February 2018. Rejuvenation Res. 2018 Feb 1. doi: 10.1089/rej.2018.2057. [Epub ahead of print] PubMed: 29390945.

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Optogenetics Shows How the Microbiome Affects Longevity

Monday, January 25th, 2021

Studies have shown that gut microbes can influence several aspects of the hosts life, including aging. Given the complexity and heterogeneity of the human gut environment, elucidating how a specific microbial species contributes to longevity has been challenging.

To explore the influence of bacterial products on the aging process, scientists at Baylor College of Medicine and Rice University developed a method that uses light to directly control gene expression and metabolite production from bacteria residing in the gut of the laboratory worm Caenorhabditis elegans.

The team reports (Optogenetic control of gut bacterial metabolism to promote longevity) ineLife that green-light-induced production of colanic acid by resident Escherichia colibacteria protected gut cells against stress-induced cellular damage and extended the worms lifespan. The researchers indicate that this method can be applied to study other bacteria and propose that it also might provide in the future a new way to fine-tune bacterial metabolism in the host gut to deliver health benefits with minimal side effects.

Gut microbial metabolism is associated with host longevity. However, because it requires direct manipulation of microbial metabolism in situ, establishing a causal link between these two processes remains challenging. We demonstrate an optogenetic method to control gene expression and metabolite production from bacteria residing in the host gut. We genetically engineer an E. coli strain that secretes colanic acid (CA) under the quantitative control of light, the investigators wrote.

Using this optogenetically-controlled strain to induce CA production directly in theC. elegansgut, we reveal the local effect of CA in protecting intestinal mitochondria from stress-induced hyper-fragmentation. We also demonstrate that the lifespan-extending effect of this strain is positively correlated with the intensity of green light, indicating a dose-dependent CA benefit on the host.

Thus, optogenetics can be used to achieve quantitative and temporal control of [the microbiome] metabolism in order to reveal its local and systemic effects on host health and aging.

We used optogenetics, a method that combines light and genetically engineered light-sensitive proteins to regulate molecular events in a targeted manner in living cells or organisms, said co-corresponding author Meng Wang, PhD, the Robert C. Fyfe endowed chair on aging and professor of molecular and human genetics at the Huffington Center on Aging at Baylor.

In the current work, the team engineered E. coli to produce the pro-longevity compound colanic acid in response to green light and switch off its production in red light. They discovered that shining the green light on the transparent worms carrying the modified E. coli induced the bacteria to produce colanic acid, which protected the worms gut cells against stress-induced mitochondrial fragmentation. Mitochondria have been increasingly recognized as important players in the aging process.

When exposed to green light, worms carrying this E. coli strain also lived longer. The stronger the light, the longer the lifespan, continued Wang, who is also an investigator at Howard Hughes Medical Institute and a member of Baylors Dan L. Duncan Comprehensive Cancer Center. Optogenetics offers a direct way to manipulate gut bacterial metabolism in a temporally, quantitatively, and spatially controlled manner and enhance host fitness.

For instance, this work suggests that we could engineer gut bacteria to secrete more colanic acid to combat age-related health issues, added co-corresponding author Jeffrey Tabor, PhD, associate professor of bioengineering and biosciences at Rice University. Researchers also can use this optogenetic method to unravel other mechanisms by which microbial metabolism drives host physiological changes and influences health and disease.

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9 Factors That Affect Longevity | ThinkAdvisor

Monday, January 25th, 2021

1. Gender: According to the Institute and Faculty of Actuaries, mortality rates for females are lower at each age than those of men. Women live longer than men, on average.The current overall life expectancy for U.S. men is 76.4 years, and 82.9 years for men at age 65. Overall life expectancy for U.S. women is 81.2 years, or 85.5 years for women at age 65.

2. Genetics: Genetics may play a role in nine of the top 10 causes of death, according to the Centers for Disease Control.

3. Prenatal and childhood conditions: Poor conditions in utero, at birth and in very early childhood are associated with higher mortality even at advanced ages, according to IFA. The Society of Actuaries has been studying the impact of early childhood conditions on exceptional longevity, including whether growing up in certain geographic areas is associated with differing life expectancies.

4. Education:Higher education levels are linked to higher socio-economic status and both are linked to improved longevity, according to Hall and Peterson. For those with a bachelor's degree or higher, life expectancy at age 25 increased by 1.9 years for men and 2.8 years for women, according to the CDC.

5. Socio-economic status: Among other things, socio-economic status can affect a persons ability to access adequate medical care and their participation in healthier lifestyle habits like exercising more, smoking less and maintaining a healthy weight.

6. Marital status: Married people have lower mortality rates than those who were never married, are divorced or are widowed, according to IFA. Various studies suggest that marriage or committed relationships may improve cardiac health, help combat isolation and loneliness that can negatively impact mental health, and motivate people to make healthier choices like keeping regular doctor visits and giving up unhealthy habits.

7. Ethnicity/migrant status: The CDC tracks data related to ethnicity and life expectancy. According to 2011 data compiled by the CDC, life expectancy is highest among Hispanic people both male and female. Life expectancy ranged from 71.7 years for non-Hispanic black males to 83.7 years for Hispanic females. Ethnicity or migrant status may also be associated with socio-economic status. (Image: Shutterstock)

8. Lifestyle: Historically, lifestyle factors that affect mortality include an unhealthy diet, inadequate exercise, tobacco use, excessive use of alcohol, risky behaviors, food safety, work place safety and motor vehicle safety. Today, the major lifestyle factor that affects mortality is obesity.

9. Medical technology: Development of antibiotics and immunizations, as well as improvements in imaging, surgery, cardiac care and organ transplants all have helped push the average life expectancy higher.

Longevity has been increasing over the past century thanks to medical advances and lifestyle improvements. Not only has the average life expectancy increased since 1900, but a larger number of people are living to older ages, driven in part by a steep decline in the high infant mortality rate that characterized the early 1900s.

Life expectancy once a person reaches age 65 is now about to 84 years of age in the United States and about 86 in Japan. Life expectancy in Australia, Canada and the United Kingdom fall between 84 and 86 for people at age 65, according to statistics from the Organisation for Economic Co-Operation and Development.

R. Dale Hall and Andrew Peterson of the Society of Actuaries detailed trends in longevity and factors that affect it at LIMRAs Retirement Industry Conference earlier this month in Boston. The pair then introduced a new longevity tool, designed tohelp consumers and advisors estimate how long of a retirement they may need to plan for. Life expectancy likely will continue to increase but at a slower rate in the future, including at older ages, they said.

Hall and Peterson outlined several factors, based on data from the Institute and Faculty of Actuaries, associated with mortality that affect whether a person is likely to live to or beyond the average life expectancy. Multiple factors influence mortality and are important to consider in financial planning for retirement.

Here are nine factors that may impact mortality and longevity.

According to the Institute and Faculty of Actuaries, mortality rates for females are lower at each age than those of men. Women live longer than men, on average.

The current overall life expectancy for U.S. men is 76.4 years, and 82.9 years for men at age 65. Overall life expectancy for U.S. women is 81.2 years, or 85.5 years for women at age 65.

Some studies attribute this gap in part to riskier behavior among men that may lead to higher rates of accidents.

There appears to be a link between genetic factors and mortality rates. Genetics may play a role in nine of the top 10 causes of death, according to the Centers for Disease Control. The CDC lists the leading causes of death in the United States as:

Poor conditions in utero, at birth and in very early childhood are associated with higher mortality even at advanced ages, according to IFA. The Society of Actuaries has been studying the impact of early childhood conditions on exceptional longevity, including whether growing up in a city or farm environment affects longevity, as well as whether growing up in certain geographic areas is associated with differing life expectancies.

Higher education levels are linked to higher socio-economic status and both are linked to improved longevity, according to Hall and Peterson.

For those with a bachelors degree or higher, life expectancy at age 25 increased by 1.9 years for men and 2.8 years for women, according to the CDC. On average, a 25-year-old man without a high school diploma has a life expectancy 9.3 years less than a man with a bachelors degree or higher. Women with a high school diploma have a life expectancy 8.6 years less than their counterparts with a bachelors degree or higher, the CDC said.

Higher education levels were also associated with lower levels of obesity and tobacco use, which may correlate with greater longevity, according to CDC data.

As socio-economic status decreases, so does life expectancy, according to the IFA. Among other things, socio-economic status can affect a persons ability to access adequate medical care and their participation in healthier lifestyle habits like exercising more, smoking less and maintaining a healthy weight.

Married people have lower mortality rates than those who were never married, are divorced or are widowed, according to IFA. Various studies suggest that marriage or committed relationships may improve cardiac health, help combat isolation and loneliness that can negatively impact mental health, and motivate people to make healthier choices like keeping regular doctor visits and giving up unhealthy habits.

The CDC tracks data related to ethnicity and life expectancy. According to 2011 data compiled by the CDC, life expectancy is highest among Hispanic people both male and female. Life expectancy ranged from 71.7 years for non-Hispanic black males to 83.7 years for Hispanic females.

Ethnicity or migrant status may also be associated with socio-economic status. Mortality of migrant people appears to vary as a result of differences in average mortality between host and home countries, as well as healthy selection for migration or return and length of residence in the host country, IFA said.

Historically, lifestyle factors that affect mortality include an unhealthy diet, inadequate exercise, tobacco use, excessive use of alcohol, risky behaviors, food safety, work place safety and motor vehicle safety. Today, the major lifestyle factor that affects mortality is obesity. Nearly 5 percent of adults are considered extremely obese, compared with about 1 percent in 1962; more than 30 percent are considered obese compared with about 13 percent in 1962; and nearly 70 percent of adults are overweight today compared with about 46 percent in 1962.

Advances in medicine and medical technology have had a major impact on increased longevity. Development of antibiotics and immunizations, as well as improvements in imaging, surgery, cardiac care and organ transplants all have helped push the average life expectancy higher.

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Hereford thrives in an uncertain year | Farm Forum | aberdeennews.com – AberdeenNews.com

Monday, January 25th, 2021

In a year that was anything but predictable, Hereford breeders and the American Hereford Association continued to add value to Hereford genetics. Year-end reports shared during the associations recent annual meeting show their efforts paid off.

As the commercial industry has looked to add crossbreeding back into the programs to increase fertility, longevity, disposition all the things that are known in Hereford cattle its created a great opportunity for us, Jack Ward, AHA executive vice president, said in a news release. Ward reports the association experienced increases in registrations and memberships this fiscal year, while sale averages climbed.

The real excitement within our breed and within our membership is in its growth, Ward says. Its seen growth because the breeders have been committed to genetic improvement and providing the tools necessary to make the changes to produce the type of product that their customers need and then, ultimately, the consumer. Its all encompassing.

A drive for genetic improvement includes a focus on the female. The association incorporated genomic information into its suite of maternal traits, and female genotypes accounted for almost 60% of the 25,000 genotypes submitted to the organization during the fiscal year.

I really think that speaks highly to our breeders commitment to really get the most of the females that theyre keeping, Shane Bedwell, AHA chief operating officer and director of breed improvement, said in the release. Youll find about a 20% to 25%, up to a 30%, increase in those maternal traits in the last three years.

The association also reports tremendous strides in other economically relevant traits, including carcass. Weve made incredible improvements in postweaning growth and end product merit, Bedwell adds. Thats evident in the amount of cattle that are now grading well in the Hereford breed. Benefits in conversion and cost of gain have more producers utilizing the Associations commercial programs like Hereford Advantage to add value to Hereford and Hereford-influenced calves.

Meanwhile, Certified Hereford Beef celebrated its 25th anniversary and another successful year. No matter where you drive in the U.S., you find Hereford cattle. Theyre adaptable, they work hard. Theyre efficient, Bedwell notes. We need efficient cattle in these times and in our production system, and Hereford genetics thrive.

Ward adds, Producers want it all and, with Herefords, you can Come Home to Hereford, use good Hereford genetics and take advantage of those opportunities.

Learn more about additional AHA opportunities or news from AHAs 2020 annual meeting at Hereford.org. Youll find a series of highlights, including the presentation of more than $150,000 in scholarships, as well as breed honorees and other Hereford news.

Virtual educational sessions covering topics from genomics to marketing are also available. Merck Animal Health, Neogen Corp., National Cattlemens Beef Association and National Corn Growers Association were among major sponsors of the AHA Annual Membership Meeting and Conference.

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Njonjo, Moody Awori: Why these wazee are still up and running – The Standard

Monday, January 25th, 2021

Former Attorney General Charles Njonjo recently turned 101. Photo: Courtesy.

Many Kenyans succumb to lifestyle diseases at relatively young ages and celebrating ones 90th birthday is no doubt a biological milestone. Former Attorney General Charles Njonjo recently turned 101. Njonjo, who is not on Facebook, Twitter or Instagram, was born in the year Kenya became a Colony and went on to outlive all who were in Kenyas first independence Cabinet. He joined that rare group of Kenyans enjoying their sunset years in the 90s Club. Others in this bracket include Kenyas first Governor of the Central Bank and Head of Public Service Duncan Ndegwa who still plays a round of golf at 95. Muthoni Likimani, the first black Kenyan to run a PR agency called Nonis Publicity, is 93 years old. But the mother of three has won other hats in her illustrious life: writer, broadcaster, radio and television producer, educationist and women rights activist. Former Vice President Moody Awori is 92.

The World Health Organisation pegs the average life expectancy in Kenya at 67. So, what made these Kenyans live so long? What diet and lifestyle habits helped them, or was it plain good old genetics?

Dr Borna Nyaoke-Anoke, a Kenyan physician and clinical researcher, argues that Kenyans were living longer in the past as they had healthier dietary choices with less processed foods and were more physically active hence did not have as many non-communicable diseases such as diabetes type two, cancer or cardiovascular diseases which lead to higher mortality rates.

READ ALSO: Five things you need to quit for a longer life expectancy

James Mbugua, a city psychologist, argues increased knowledge and advanced technology has not helped matters considering many people hardly take their health seriously and instead opt for quick fixes in drugs.

Njonjo, for instance, has often mentioned keeping to a frugal diet of a cup of tea and two toasts of bread in the morning, and lots of fruits and vegetables at lunch and supper. He dispenses with nyama choma, preferring fish and other white meat. The former Constitutional Affairs minister is husband of Margret Bryson and father of three children a lawyer, scientist and veterinary doctor. He also does occasional drink alcohol, but only a bottle of beer strictly a cider.

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In a previous interview, Njonjo, who remained a bachelor until he was 52, said: I look after myself. I swim daily. I used to do 12 laps, now I do only seven. I also have a bicycle which I ride for 10 minutes daily, on top of the treadmill which I do for 10 minutes daily. Im also careful about what I eat; I dont eat nyama choma. I eat a lot of veggies.

Being busy also counts. When he retired from public service, Njonjo immersed himself in business and wont stop working unless Maybe when Im cremated. Otherwise I will wait until I cannot move a limb, he said.

Besides lifestyle, Njonjos family is known to live long lives meaning genetics could also be at play as his father, Chief Josiah Njonjo was still strong when he was facing the Njonjo Commission of Inquiry in 1984. Njonjo was in his 60s, the father in the 80s.

Duncan Ndegwa, the former Central Bank of Kenyatta retired to his businesses and among his regimens is playing golf. He once said, The way you are on the golf course, is the way you are in life. Without golf, my life would have been poorer. I have no regrets in activity spent in golf.

READ ALSO: These innocent habits can send you to the grave

Uncle Moody, the one-time career assistant minister became Vice President after the demise of Wamalwa Kijana at a London hospital in 2003. He and his 14 siblings have dominated politics, education, commerce, medicine, engineering, sports and academia, but the long life for the father of five can be pegged on among others; 30 press ups and floor exercises every morning. As he once explained, I lie on my back and then I flip over until my feet touch the ground. Then I get up and do that again 150 times.

When asked about her longevity, Muthoni, a former beauty queen, who hardly sleeps beyond 4am said, God has been kind to me. African food has also helped me remain strong. I eat uji made from three different types of millet and I dont drink.

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Njonjo, Moody Awori: Why these wazee are still up and running - The Standard

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Son reported father to FBI weeks before he reportedly stormed the Capitol – Yahoo News

Monday, January 25th, 2021

The Daily Beast

GettyAghast over former President Donald Trumps decision to authorize a series of last-minute federal executions before departing the White House, progressives are starting to exert pressure on President Joe Biden to get specific about his timeline and planned approach to ending capital punishment.The argument, shared widely among left-aligned Democrats in Congress and reform advocates, is rooted in the belief that being antithetical to Trump on the death penalty is a crucial first step to eradicating a racially biased criminal justice system. As Bidens first 100 days in office begin to take shape with no political barriers, many believe the newly elected president has a moral imperative to actively help dismantle racist systems in government early on. And they are not expected to ease up as the administration works through its preliminary priorities.Theres all kinds of room for what Ill call political jujitsu thats going to happen on the part of the Biden administration that is... going to seek to slow down the progressive movement, said Stacey Walker, a supervisor in Linn County, Iowa, and appointee to the criminal justice unity task force developed between Biden and Sen. Bernie Sanders (I-VT) during the 2020 presidential election.This one is different to me, Walker said.After Biden secured the Democratic nomination, his campaign worked with Sanders allies like Walker to form party consensus around key criminal justice and prison reforms. Ending the death penaltya stance Biden started to come around to early into his bidwas one of the strongest unifiers between the two factions, according to a source involved in the discussions.Now, with a Democrat in the White House, many believe they have a supportive ally who will set a contrasting tone to Trump and temporarily halt the practice by executive action. With control of both chambers in Congress additionally in their favor, those same voices are confident that legislation will pass relatively easily, bolstered by approval by rank-and-file Democrats and Republicans alike. According to a recent Gallup survey, support for the practice is strikingly low.We have to continue to apply pressure, to keep up the fight, to halt federal executions, to ultimately abolish the federal death penalty in its totality, said Rep. Ayanna Pressley (D-MA), a leading criminal justice reform advocate in the House in a segment on The Appeal. They have a mandate to do this from the people.The contours of Bidens stated early-term agenda includes a sharpened focus on addressing racial inequity as one of many national crises. After a summer of mass protests sparked by the killing of George Floyd by police, Biden built out the specifics of his proposed justice agenda. In his Jan. 20 inauguration address, he explicitly said: We can deliver racial justice, indicating that he believes the goal is achievable. A cry for racial justice some 400 years in the making moves us, he continued. The dream of justice for all will be deferred no longer.Feds Will Try to Reinstate Death Penalty for Convicted Boston Marathon BomberAs his early days in office unfold in the wake of a violent insurrection at the Capitol carried out by predominantly white perpetrators, the multifacets of justice issues have returned to full view. That notion was further tested after Trump made the alarming decision to execute five individuals just before his term in office ended, bringing the total to 13 during his administration.From our perspective, there should be no roadblocks, said Sakira Cook, justice reform director at the Leadership Conference on Civil and Human Rights. Its widely understood and accepted that three things are true: Ending the death penalty is essential to advancing any other priority around transforming the criminal legal system; there is growing momentum against the death penalty across this country and at the federal level; and the death penalty is equally flawed across racial lines in particular.White House press secretary Jen Psaki has so far declined to provide specifics on Bidens plans and timing. Asked on Inauguration Day by a reporter about a possible moratorium, she reiterated the presidents prior objection to the practice, adding that it remains his view today.Some Democrats and advocates argue that Biden would be wise to sign an executive order as a first signal of leadership, an action that would draw an intense contrast between his start and Trumps finish. But without guidance yet from the administration, congressional progressives are moving forward legislatively in the interim.Last week, Pressley and Rep. Cori Bush (D-MO), a leading Black Lives Matter activist turned freshman member of Congress, sent a letter to Biden contextualizing the issue as a way to demonstrate a broader commitment to racial equality. Pressleys House bill, known as the the Federal Death Penalty Prohibition Act, along with Sen. Dick Durbins (D-IL) version in the Senate, would end the death penalty once and for all, the letter states.Rep. Adriano Espaillat (D-NY), deputy whip of the House Progressive Caucus, said he believes there is growing momentum in Congress around the issue, particularly now with Democrats in control and an on-the-record pledge from the president. There is traction in Congress to abolish it, he said during a forum with Columbia University.While Espaillat believes that a moratorium is a good initial step, he also acknowledges that penning a temporary end to the practice does not go far enough. Executive orders, which were frequently used by both the Obama and Trump administrations, are subject to reversal by the political party in power and are seen as non-permanent solutions.It is an extension or continuation of the progress Barack Obama made, said state Sen. Raumesh Akbari (D-TN), a Biden appointee on the Biden-Sanders task force. I know that people were pleased with the Obama administration, but some felt they wished additional drug-related sentences would be commuted.There is a strong sentiment among Democrats supportive of former President Barack Obama that the 46th president should go further than his old boss on the issue. During his eight years in office, Obama commuted only two federal death sentences. Part of the thinking that Biden should take more action stems from his role in the 1994 crime bill, which significantly expanded the number of offenses for which individuals could be put to death. On the campaign trail, Biden called it a mistake.There are currently 49 individuals on death row, according to the most recent data from the Death Penalty Information Center, including Dzhokhar Tsarnaev, the man who plotted and carried out a deadly bombing during the 2013 Boston Marathon. The Supreme Court is expected to announce soon whether they will hear the case. Sen. Elizabeth Warren (D-MA) has stated opposition to Tsarnaev receiving the death penalty.The governments got to be better than the basic instincts of man, Walker said. Its got to be bigger than that. And its got to recognize that this is a relic of a pre-futile era of this world where someone in a high chair gets to decide who lives and dies. Thats not who we are.Read more at The Daily Beast.Get our top stories in your inbox every day. Sign up now!Daily Beast Membership: Beast Inside goes deeper on the stories that matter to you. Learn more.

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Study of More Than 1 Million People Finds Intriguing Link Between Iron Levels And Lifespan – ScienceAlert

Tuesday, January 5th, 2021

A massive study published in 2020 found evidence that blood iron levels could play a role in influencing how long you live.

It's always important to take longevity studies with a big grain of salt, but the research was impressive in its breadth, covering genetic information from well over 1 million people across three public databases. It also focused on three key measures of ageing: lifespan, years lived free of disease (referred to as healthspan), and making it to an extremely old age (AKA longevity).

Throughout the analysis, 10 key regions of the genome were shown to be related to these measures of long life, as were gene sets linked to how the body metabolises iron.

Put simply, having too much iron in the blood appeared to be linked to an increased risk of dying earlier.

"We are very excited by these findings as they strongly suggest that high levels of iron in the blood reduces our healthy years of life, and keeping these levels in check could prevent age-related damage," said data analyst Paul Timmers, from the University of Edinburgh in the UK.

"We speculate that our findings on iron metabolism might also start to explain why very high levels of iron-rich red meat in the diet has been linked to age-related conditions such as heart disease."

While correlation doesn't necessarily mean causation, the researchers used a statistical technique called Mendelian randomisation to reduce bias and attempt to infer causation in the data.

As the researchers noted, genetics are thought to have around a 10 percent influence on lifespan and healthspan, and that can make it difficult to pick out the genes involved from all the other factors involved (like your smoking or drinking habits). With that in mind, one of the advantages of this new study is its sheer size and scope.

Five of the genetic markers the researchers found had not previously been highlighted as significant at the genome-wide level. Some, including APOE and FOXO3, have been singled out in the past as being important to the ageing process and human health.

"It is clear from the association of age-related diseases and the well-known ageing loci APOE and FOXO3 that we are capturing the human ageing process to some extent," wrote the researchers in their paper published in July 2020.

While we're still in the early stages for investigating this association with iron metabolism, further down the line we could see the development of drugs designed to lower the levels of iron in the blood - which could potentially add extra years to our lives.

Besides genetics, blood iron is mostly controlled by diet and has already been linked to a number of age-related diseases, including Parkinson's and liver disease. It also affects our body's ability to fight off infection as we get older.

We can add this latest study to the growing evidence that 'iron overload', or not being able to break it down properly, can have an influence on how long we're likely to live, as well as how healthy we're likely to be in our later years.

"Our ultimate aim is to discover how ageing is regulated and find ways to increase health during ageing," says Joris Deelenwho studies the biology of ageing at the Max Planck Institute for Biology of Ageing in Germany.

"The 10 regions of the genome we have discovered that are linked to lifespan, healthspan, and longevity are all exciting candidates for further studies."

The research has been published in Nature Communications.

A version of this article was first published in July 2020.

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Study of More Than 1 Million People Finds Intriguing Link Between Iron Levels And Lifespan - ScienceAlert

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Hereford Thrives in an Uncertain Year – AG INFORMATION NETWORK OF THE WEST – AGInfo Ag Information Network Of The West

Tuesday, January 5th, 2021

In a year that was anything but predictable, one constant held fast: Americas farmers and ranchers and, among them, Hereford breeders.

In this year-end report from the American Hereford Association (AHA), we learn how Hereford cattlemen and women grew the breed through 2020.

Despite the unforeseen challenges of 2020, AHA Executive Vice President Jack Ward says Hereford breeders and the American Hereford Association continued to add value to Hereford genetics. Year-end reports shared during the Associations recent annual meeting show their efforts paid off.

"As the commercial industry has looked to add crossbreeding back into the programs to increase fertility, longevity, disposition all the things that are known in Hereford cattle its created a great opportunity for us said Ward.

Ward reports the Association experienced increases in registrations and memberships this fiscal year, while sale averages climbed.

The real excitement within our breed and within our membership is in its growth" said Ward. "Its seen growth because the breeders have been committed to genetic improvement and providing the tools necessary to make the changes to produce the type of product that their customers need and then, ultimately, the consumer. So its all encompassing.

Learn more from the American Hereford Associations virtual educational sessions and 2020 annual meeting at Hereford.org.

Youll find a series of highlights, including the presentation of more than $150,000 in scholarships, as well as breed honorees and other Hereford news. Virtual educational sessions are also available and cover topics from genomics to marketing.

Source: American Hereford Association

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Hereford Thrives in an Uncertain Year - AG INFORMATION NETWORK OF THE WEST - AGInfo Ag Information Network Of The West

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Covid-19 Update Precision Medicine Software market: Poised to Garner Maximum Revenues by 2027 with major key players in the market Syapse, Allscripts,…

Tuesday, January 5th, 2021

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Covid-19 Update Precision Medicine Software market: Poised to Garner Maximum Revenues by 2027 with major key players in the market Syapse, Allscripts,...

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The New Anti-Ageing: How the pandemic unlocked new ways to lower your biological age – Telegraph.co.uk

Tuesday, January 5th, 2021

While most scientists look at Covid-19 as a viral respiratory illness, Nir Barzilai takes a slightly different perspective. Instead Barzilai, founder of the Institute of Ageing Research at the Albert Einstein College of Medicine in New York, sees it as a disease of ageing.

The grim statistics show that he has a point. In Europe, people over 60 have accounted for 90% of fatalities since the start of August. While the impact of Covid-19 has been universal, older people have been disproportionally affected.

This virus has no eyes, but it could see immediately who is old and more vulnerable, says Barzilai.

For Barzilai and other geroscientists scientists who study the biology of ageing this represents an opportunity. They have long argued that we need a different perspective for tackling many chronic diseases, from cancer to Alzheimers. As all of these illnesses become more common with age, geroscientists have suggested that therapies attempting to reverse some of the cellular mechanisms of ageing, might make older individuals more resilient to a whole range of diseases.

The premise of this approach is that while we typically measure age chronologically, the number of years we have been alive, your biological age says far more about your health. Biological age is indicated through various biomarkers ranging from the length of telomeres the tips of chromosomes to changes in DNA expression, and even your gut microbiome.

Some 55-year-olds may be biologically equivalent to 45, making them more resilient to disease, while others may be far older, due to lifestyle or genetics.

Since the 1930s, scientists have identified certain drugs which appear capable of reversing biological ageing in mice. Over the past nine months, the pandemic has provided increasing evidence they may be capable of doing the same in humans. Covid has moved anti-ageing from hope to promise, says Barzilai. The promise is that ageing is flexible, and can be manipulated, is something weve shown again and again in animals.

Geroscientists have defined eight hallmarks of biological ageing, which when targeted can improve health and lifespan in animals. These hallmarks range from declining immune function, to a decrease in the quality and quantity of mitochondria the energy factories of our cells and an impaired ability of cells to perform garbage disposal and remove toxins or viruses.

There are drugs which can target some hallmarks of ageing, including resveratrol - a compound found naturally in foods such as blueberries but the impact of Covid-19 has sparked particular interest in a cheap, commonly available medication called metformin, which has been used to treat diabetes for over fifty years, due to its ability to lower glucose levels. But recently, epidemiologists have begun to notice people taking it for diabetes also appeared to have reduced rates of cardiovascular disease and cancer.

When the pandemic began, an early study from a hospital in Wuhan sparked particular interest. It showed diabetics taking metformin were much less likely to die of Covid-19 than diabetics not on the drug. Geroscientists around the world took note.

Because of the number of people contracting Covid-19, we could gather data on metformin and its impact on reducing mortality, which would otherwise have taken years to collect, says Vadim Gladyshev, a biochemist at Harvard Medical School.

Soon, further studies yielded similar findings. Doctors at the University of Minnesota found metformin lowered mortality rates across more than 6,000 Covid-19 patients with diabetes, albeit only in women.

Barzilai believes he understands why. In a paper published earlier this year, he showed that metformin targets all eight hallmarks of ageing at the same time. Now, this accumulation of evidence has helped convince investors to provide $75 million in funding for a landmark randomised control trial called TAME.

Intended to begin in June 2021, it aims to see whether giving metformin to older people for four to five years, can give them more years of good health. If this proves successful, it could see metformin licensed by regulators as the worlds first clinically proven anti-ageing therapy.

In April, Edwin Lam, a pharmacologist at Thomas Jefferson University, was looking at AI-based predictions of potential Covid-19 treatments and found a drug called rapamycin ranked higher than many highly touted alternatives.

Rapamycin is currently used to prevent organ transplant rejection, but geroscientists have been interested in its effects on longevity for decades. It specifically targets a pathway called mTOR, a major driver of many of the cell degradation processes that occur with ageing. Because rapamycin inhibits mTOR, it can help reactivate different parts of the immune system, making them behave like a younger person.

Boston-based biotech company resTORbio have previously shown that forms of rapamycin can reduce rates of respiratory infections in over 65s. They are now conducting a clinical trial in the US, looking at whether giving rapamycin to nursing home residents on a daily basis, could protect them from becoming severely infected with Covid-19. If successful, it could pave the way for rapamycin becoming a new treatment for protecting older people from seasonal infections, and future viral outbreaks.

The renewed interest in biological ageing as a result of Covid-19, could also yield benefits for other diseases linked to the ageing process, in particular Alzheimers. For years, pharma companies have attempted to develop treatments which target the accumulation of amyloid proteins in the brain during the course of the disease.

With Covid-19 increasing the spotlight on how ageing makes people more vulnerable to disease, Alzheimers scientists have begun to consider alternative approaches. I think neurologists are becoming more open to the idea that we have been too insensitive to the ageing context in which Alzheimers occurs, says Jeffrey Cummings, professor of neurology at UCLA. Most patients have the onset of their disease in their 80s, where you get this accumulation of multiple adverse influences on cognitive function.

One particular clue about how to prevent this accumulation may lie in our DNA. As we age, telomeres become shorter, leading to a variety of cell changes. However, in 1984 biologists Elizabeth Blackburn and Carol Greider discovered an enzyme produced in cells called telomerase which naturally prevents telomere shortening, a finding which won them the 2009 Nobel Prize.

Telomerase levels also decline with age, but in recent years pharma companies have begun to wonder whether artificially boosting telomerase through drugs, could prevent age-related diseases.

Seoul-based pharma company GemVax have developed a product named GV1001 which boosts telomerase levels in cells, with the aim of seeing whether it can prevent decline in Alzheimers patients and prevent the onset of the disease altogether. In a recent Phase II clinical trial of moderate to severe Alzheimers patients, they reported promising results on an assessment tool called the severe impairment battery (SIB) scale. The results exceeded our expectations, said Jay Sangjae Kim, chairman of GemVax.

With the major test a Phase III trial which is set to get underway in 2021 still to come, the results must be viewed cautiously, but the success of GV1001 has the potential to yield a new frontier of telomerase based drugs for age related diseases.

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The New Anti-Ageing: How the pandemic unlocked new ways to lower your biological age - Telegraph.co.uk

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A Good Age: Auld lang syne to the eldest who inspired and entertained us – The Patriot Ledger

Tuesday, January 5th, 2021

Sue Scheible|The Patriot Ledger

QUINCY -- Dorothy "Dot" Cole was a reluctant interview at the age of 98 in 2016. "The only time you belong in thenewspaper is for your obituary," she said. "No one wants to hear you bragging about yourself before that."

I was fortunate to be able to coax a few stories out of Dot,a charmer who was still working from the home in Weymouth where she had lived her entire life. After that, she wouldn't talk to me again when she reached age 100. Dot would have turned 102on Christmas Day this year but died Dec. 10 at home. Her obituary gave her arepeat appearance in the paper where she recapped the facts of her life.

At the opposite end of the publicity spectrum of remarkable elders I have met was the irrepressible Ruth Kundsin of Quincy, a "Let's go for it" interview subject from the start. Tipped off by her friends,I wrote about her becoming a centenarian in 2016 and followed her each year after. She surprised and delighted readers and drew national attention:at age 103 she was working out with herpersonal trainer Dick Raymond weekly at the South Shore YMCA in Quincy

She kept that regimen up until this year, when at 104 she decided enough was enough in July. She was working on a book about her pioneering professional life as a microbiologistwhen shedied at home on Thanksgiving Day, family and friends by her side. Ruth was anAssociate Professor of Microbiology and Molecular Genetics, Emerita, at Harvard Medical School. Her groundbreaking research on airborne pathogensled to important changes in hospital and operating room protocols.

Turning 104, Ruth Kundsin of Quincy tells it like it is

As retired microbiologist Ruth Kundsin turns 104, she wonders if it's time to stop her workouts with a personal trainer at the South Shore YMCA.

Sue Scheible, The Patriot Ledger

In May, the legendary Mary Pratt of Quincy died at age 101 after a long and illustrious career teaching physical education and fighting for the rights of women in sports. In 1943, Pratt became a pitcher in the All-American Girls Professional Baseball League.

She was one of the first members of the Rockford Peaches,the team featured in the movie "A League of Their Own."

As a youngster, she loved playing ball with the boys in her Connecticut neighborhood. Her family moved to Quincy; she graduated from North Quincy Highand attended Sargent College of Physical Education at Boston University.

At age 24, Pratt was scouted for the brand new All-American Girls Professional Baseball League. She played ball for five years, returned to Quincy and was passionate about teaching physical educationfor 48 years, including three in Braintree and 42 in Quincy.

She became a passionate fighterfor new opportunities for women in sports and more leadership positions.

When Pratt was in her 90s, she moved to 1000 Southern Artery senior housing in Quincy. Herneighbors included some of her former students who knew her as their gym teacher in grade school.Helen Colette, 80, was walking through the lounge one day when she spotted that familiar face from the past.Colette was standing with her hands in her pockets when Mary sized her up and said approvingly, Look at her, standing so tall and nice and straight. Her shoulders match her hips and her hips match her ankles.

Another effervescent phenom was Agnes Mullay of Quincy, who died in Aprilthree weeks after her 108th birthday at Alliance Health at Marina Bay Nursing Center. She hadloved to sit in the lobby and greet people.At 4-foot-8, she was a tiny woman with a rich chuckle and sparkling smile.

A less visible but equally large loss was that of Shirley Bartlett of Weymouth, who was 93, had survived COVID, recovered and then died last summer.Shirley had a large circle of friends, was an aunt, great-aunt, and great-great-aunt to many nieces and nephews. She belonged to the Weymouth Newcomers Club, the Castle Island Association,participated in choral groups and line dancing and sang at nursing homes.

It is such aprivilege to have met and interviewed these and other South Shore elders and to have heard their stories. They have shared their secrets and ways of adjusting to long life with wisdom and a positiveperspective.They remain present in our memories,their achievements and their stories.

In the weeks ahead, we'll catch up with others who continue to lead the way in longevity.

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A Good Age: Auld lang syne to the eldest who inspired and entertained us - The Patriot Ledger

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Survival Of The Kindest: A New Mantra To Rebuild The Global Economy – Forbes

Tuesday, January 5th, 2021

Lessons from nature may hold deeper insights into how to build back a more resilient and kinder ... [+] economic system

That our current global economic system is broken is no surprise. The question is where to turn to for hope. New insights from nature may provide the answer.

The "Fearless Girl" statue, a four-foot statue of a young girl, defiantly looks up the iconic Wall ... [+] Street "Charging Bull" sculpture in New York City

Underlying economic injustices have been magnified by the coronavirus pandemic. Historically underrepresented groups have all fared worse off over the past 12 months since the outbreak of the virus. A younger generation now faces a historic amount of debt, similar to having faced a World War, in addition to the challenges of irreversible climate change and global biodiversity collapse.

24 Feb 2020: Indian billionaire Mukesh Ambani (L) added $18 billion to his wealth during the ... [+] pandemic, as Microsoft value rose by almost $500 billion in 2020. Seen here with Microsoft CEO Satya Nadella (R)

A closer examination of this growing inequality reveals just how fragile current economic structures have become, with social unrest bubbling just under the surface in many countries around the world. As hundreds of millions continue to face prolonged lockdowns, higher health risks, lost schooling, mass unemployment and economic ruin, ten billionaires alone saw their wealth increase by $450 billion during the pandemic. The wealthiest 2000 billionaires in the world saw their assets hit new highs, increasing toover $10 trillion in value. An economic system with such disparities, that rewards those with access to capital, is not sustainable.

Political leaders around the world performed poorly in responding to the coronavirus crisis (Bill Gates questioned whether any country merited an A grade for their response).

A new Covid-19 stimulus plan was signed by President Trump at the end of 2020

These very same political leaders (many of whom are increasingly authoritarian) are now using taxpayer funds or future borrowing to roll out multi-trillion dollar pandemic stimulus packages around the world. Rather than coordinating such a financial injection to ensure a global economy is rebuilt in a way that is more just, equitable, innovative and harmonious with nature, the world is seeing a fragmented patchwork of short term, reactive measures that do not address the structural faults in the global economy, or appear to be coordinated in any way to address global systemic risks.

The multi-trillion dollar opportunity is being squandered, and history shows that this will be an expensive mistake.

There are small windows in history when human value systems shift so fundamentally in a short period of time that the entire economic system is forever altered after such crises. In several instances, these shifts in human values have improved the state of the world. For example:

Slavery abolished by mid-1850s

Eleanor Roosevelt and 'The Universal Declaration of Human Rights'

U.S. Civil Rights activist Rosa Parks seated toward the front of the bus, Montgomery, Alabama, 1956. ... [+]

Swedish climate activist Greta Thunberg is pictured during a "Fridays for Future" protest in front ... [+] of the Swedish Parliament Riksdagen in Stockholm on October 9, 2020.

The last decade has seen a regression of much of the progress of the 20th century as inequality of opportunity has risen around the world. The international responses to the 2008 and 2011 financial crises were wasted, as the then $1 trillion stimulus packages coordinated via the E.U., G20, World Bank and IMF ended up recreating existed cleavages in society, which were already unsustainable, as a decade of austerity eroded critical social safety nets around the world.

With social cohesion breaking down and irreversible climate change soon upon us, the time for timid steps are over.

A strong articulation of which values will need to change is needed to build a more robust ... [+] post-pandemic economy

Building back better must mean that the means should justify the ends. There cannot be a rush toward more a sustainable economy that create new green monopolies. The growth must be inclusive.

The core to building back a better economic system will require the architects of the post-pandemic economic order to come to terms with a foundational error in science from 150 years ago, that continues to plague the global economy today.

It is to do with a fundamental misunderstanding of the natural world, which led to the birth of modern economic thinking. It is this system of incentives that now define the winners and losers of the global economic system, including its impact on the society and the environment.

Advances today in molecular biology and advanced genetics are revealing new insights into how misguided this science was 150 years ago, and the profound implications for how the economic system can be redesigned.

Charles Darwin, English naturalist, wrote the first unifying theory of evolution

In 1859, a 48-year old Charles Darwin famously completed his iconic book the On the Origin of Species, after travelling the world on a scientific expedition on board The Beagle. Origin of Species became the seminal work that provided a unifying theory for evolution and natural selection for the first time. Indeed, the full title of the book was, On the Origin of Species by Means of Natural Selection, or the Preservation of Favoured Races in the Struggle for Life. It became the predominant doctrine of many leading thinkers of the time such as Alfred Wallace and Thomas Malthus.

At the core, was an assumption that there were winners and losers in evolution. This led to the term the Survival of the Fittest to explain who the winners of evolution were. This process was termed Natural Selection.

The notion of a Natural Selection of winners was swiftly taken up by researchers at the time as the lens through which to study nature, wildlife and biology. European biologists were captivated by the notion that brutal forces of nature defined that only the fittest or most selfish would survive. Darwins work led to a unifying-theory of a well-structured biological pecking order, explained by a simplified and precise mathematical formula that defined the position of each species, with the most powerful on top. It was very Victorian England.

A lion epitomizing 'survival of the fittest' against a zebra

Nothing exemplified this more than the imagery of the powerful, carnivorous lion chasing its herbivorous prey across the plains of Africa. A process of natural selection would determine which species would be at the top of the food chain, a product of what skills they needed to survive over thousands of years of evolution. Those at the top of these biological pyramids could expect to die of old age, whereas life for other creatures lower down would be brutal, short and defined by constantly being on their guard.

Although a fringe notion at the time in the 1860s, it would take another seventy years for Darwins theories of evolution, natural selection and the survival of the fittest to become mainstream by the 1930s.

This theory of natural selection explained by the concept of survival of the fittest then went on to dominate scientific thinking for the next 100 years through to today.

President Franklin D. Roosevelt endorses New Deal candidates during a radio broadcast from his Hyde ... [+] Park home. | Location: Hyde Park, New York, USA.

Darwins theories originated in evolutionary biology, but soon infused itself into the leading economic, social and political thinkers of the time.

In the fervent first three decades at the start of the 20th century with a World War, a Spanish Flu pandemic, a Great Depression and New Deal Recovery, economists and political scientists were searching for new unifying economic theories to find an alternative economic models than one of dominant robber baron monopolies built during the modern industrial revolutions of the late 19th and early 20th century.

Darwins ideas around survival of the fittest soon fit in well with notions of what was seen as a natural order for business, economics and the social sciences.

The New York Stock Exchange on Wall Street epitomizes the aggressive form of shareholder capitalism ... [+] that drives the global economy today

Iterations of this brutal winner rises to the top world became core to business and economic thinking over the course of the twentieth century. This mantra defined internal working cultures within companies, competition regulations, and core decision-making at the very top of corporations where the Board of Directors had a disproportionate say over the direction of a company, overriding concerns from employees, the environment, suppliers, and the local community. It was a scarcity mindset where there was only room on top for just a handful of organizations or leaders. Relatively little effort was made to invest in alternative, more collaborative business models or ecosystems.

It was a way of thinking that valued competition above collaboration, selfishness above empathy, aggression above pacifism.

Traders work during the opening bell at the New York Stock Exchange (NYSE) on March 19, 2020, at ... [+] Wall Street in New York City.

For over a century, it was believed that only the most self-serving businesses or leaders (usually alpha-male) should be allowed to survive. The thinking was that this would create a fitter and more robust economic system as a whole. Even if every decade, the list of most valuable businesses may change as different sectors reached their zenith, there was faith that shareholder capitalism would lead to a better outcome for society. GDP and market capitalization became the new Gods.

However, what it ended up creating was a more brutal version of business. One where quarterly results trumped all decision-making within a company. Business executives would do anything to hit quarterly targets. Other stakeholders (customers, employees, suppliers, the environmental, the local community) were given significantly lower weight, and were usually seen as marketing gimmicks.

Facebook has been seen catering more to shareholder interest than that of its users

Even companies whose humble origins once gave hope that such a system could be upended - companies like Google and Facebook - have now become the poster children for this winner takes all business model. Just as banks were too big to fail a decade ago, Big Techs dominance has created major weaknesses in modern economic and social systems. The pursuit of quarterly profits mean that efforts such as ethical A.I. or ensuring full external oversight of operations, were scaled back.

For national economies to build back better, this broken model of shareholder capitalism has to be fundamentally addressed as part of any stimulus package.

It requires re-evaluating what Survival of the Fittest means.

Emperor Penguin chicks in the Weddell Sea, Antarctica.

In recent years, new advancements in molecular biology and DNA technology have fundamentally challenged Darwins thinking and inferences on natural selection.

It has allowed biologists to go further and deeper in their understanding of evolution, and question whether natural selection really was due to a survival of the fittest. Indeed, it questioned what fittest actually meant.

Studying fossils, ancient DNA and using large datasets and machine learning to develop unprecedented insights, scientists have been able to peer back through deep time to see when various species started to evolve along the tree of life.

Scientists are making new discoveries about evolution, using new techniques of big data and machine ... [+] learning to peer further into each species' evolution and genetic code

A search through deep time reveals that species that have survived the longest are ones that live in groups, have symbiotic relationships with other species and who behave kindly within the communities that they live in. This completely flips on its head some of thinking from 150 years ago that only humans had higher faculties of intelligence, empathy and peaceful co-existence in group settings.

Taking these learnings from nature and transplanting them into our current economic systems has fundamental implications for how to build back better and the sorts of institutions that will be needed. Lets first understand the science behind Survival of the Kindest.

It turns out that species that live in groups - whether herds, shoals or flocks - tended to have survived as a species for longer than those that are more solitary.

Herd animals have been found to have evolved and survived for longer than many apex predators like ... [+] lions

Hammerhead sharks evolved 20 million years ago, less than half the time than bluefin tuna

A British Used Postage Stamp Showing Portrait of Charles Darwin and Finches, depicting his Theory of ... [+] Evolution

Charles Darwin did not have the ability to study the deep genetics of species when writing Origin of Species. Otherwise, he may have concluded the importance of a community surviving, rather than individual animals.

A more recent and deeper understanding of wildlife has revealed how dependent many species are on symbiotic relationships. The survival of one is highly dependent on the existence of another species. This is not an extractive, food-dependency, but one where the presence of both species working in harmony leads to flourishing communities growing.

Here are some notable examples:

Coral reefs are the one of earths most complex ecosystems, containing over 800 species of corals and ... [+] one million animal and plant species.

Oceanic whitetip shark with Pilot Fish swims under sea surface in the open sea, Red Sea, Egypt

Meerkat family on lookout

So collaboration - rather than competition - with different animals is critical to the survival of both species. Certain species have even developed evolutionary traits (such as the rear legs of the urchin crab) to take into account this symbiotic relationship with other species. Again, these were observations that Charles Darwin was unable to take as he rushed around the world taking observations of plants, animals and fossils he could see in the time he had available.

Frans de Waal's work has been published as New York Times bestsellers

Some of the most seminal work on animal intelligence and animal empathy has been done by Frans de Waal of Emory University. His detailed studies of chimpanzees and other Great Apes have revealed previously unrecognized behavioral patterns in animals where kindness and collaboration are rewarded in communities in which they live.

This reward structure means that apes that demonstrate the greatest empathy and collaboration often receive the highest rewards. Also chimpanzees given a free choice between helping only themselves or helping themselves plus a partner, prefer the latter.

This flips on the head the notion that nature is selfish, brutish and short for animals compared with human existence. It has given rise to an entire new field of study for morality grounded in biology, centered around values of cooperation,altruism, and fairness.

The complex and collaborative societal structures of apes are only just being understood

Such research is challenging some of the root causes of natural selection and the simplistic reasoning behind Survival of the Fittest.

As such knowledge is being revealed, it raises the question whether a new theory is needed to explain natural selection over deep time.

Perhaps it is less Survival of the Fittest and more Survival of the Kindest.

Could Survival of the Kindest be a new organizing principle for the post-pandemic economic order?

Taking this new understanding from biology into our economic systems, opens up radically new possibilities.

These new possibilities challenge the current orthodoxy that business systems should only incentivize strong corporations that seek to defeat competition, maximize corporate behavior that is self-serving and diminish the responsibility to other stakeholders (such as customers, suppliers, workers, the environment, the community) in order to only satisfy only one stakeholder - the shareholders as represented by a Board of Directors.

If kindness becomes an attribute that is core to how a business or economic system is evaluated, a different form of organization may emerge. An organization that sees their duty as performing a societal duty, much like a village market or local neighborhood grocery store performs. An organization that seeks to serve in a more balanced way rather than aggressively extract value from others in its ecosystem.

Senate Hearings in July 2020 call upon Amazon CEO Jeff Bezos (top, C), Facebook CEO Mark Zuckerberg ... [+] (top, R), Google CEO Sundar Pichai (bottom, L), and Apple CEO Tim Cook on the dominance of technology companies

Advances in technology (such as open source software) has opened up new and innovative collaborative business models that could create more symbiotic corporate relationships with a wider ranger of participants, rather than the natural monopolies that the tech giants of the FAANGs (Facebook, Amazon AMZN , Apple AAPL , Netflix NFLX , Google GOOG , Microsoft MSFT ) have created.

Survival of the Kindest will take a new form of regulatory mindset, as well as leadership mindset at every level of an organization. It means a fundamental evaluation of what kindness means, and how this value can be demonstrated toward a customer, an employee, a supplier and the environment.

Unity and diversity partnership as heart hands in a group of diverse people connected together ... [+] shaped as a support symbol expressing the feeling of teamwork and togetherness.

Creating an economic system that rewards kindness over power, may start to right the injustice and fragility with the current economic model. If it is the key to longevity for many species in deep time, there may be valuable lessons for the way that humans should be thinking about organizing society.

It may also require a new set of systems thinkers in Board Rooms and among regulators to start to rethink how the global economy needs to be built back. Getting thinkers who operate the current to imagine a radically different future is akin to asking a lion to design a system that would better suit healthy gazelle populations.

Those who have demonstrated such kindness may be the most credible role models to start that reconstruction. It will take a different sort of organizational muscle and diverse talent to build such kinder organizations, but one that is not that hard to find if one knows where and how to look.

Baby elephant showing affection to it's mother on the Masai Mara in Kenya

The extension from biology to political-economy seem may appear far-fetched, but as the economic system stretches further and further into the natural world, there are more connections than may immediately be imagined. And advances in science and technology are revealing just how little we truly understand about ourselves and the planet.

It is clear the world needs to move beyond the pithy slogans of build back green, and build back better, into something more substantive.

Perhaps this starts with Building back Kinder.

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Survival Of The Kindest: A New Mantra To Rebuild The Global Economy - Forbes

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The Nashville bombing suspect sent packages to people across the country containing typed conspiracy theories about September 11 and lizard people,…

Tuesday, January 5th, 2021

The Telegraph

While most scientists look at Covid-19 as a viral respiratory illness, Nir Barzilai takes a slightly different perspective. Instead Barzilai, founder of the Institute of Ageing Research at the Albert Einstein College of Medicine in New York, sees it as a disease of ageing. The grim statistics show that he has a point. In Europe, people over 60 have accounted for 90% of fatalities since the start of August. While the impact of Covid-19 has been universal, older people have been disproportionally affected. This virus has no eyes, but it could see immediately who is old and more vulnerable, says Barzilai. For Barzilai and other geroscientists scientists who study the biology of ageing this represents an opportunity. They have long argued that we need a different perspective for tackling many chronic diseases, from cancer to Alzheimers. As all of these illnesses become more common with age, geroscientists have suggested that therapies attempting to reverse some of the cellular mechanisms of ageing, might make older individuals more resilient to a whole range of diseases. The premise of this approach is that while we typically measure age chronologically, the number of years we have been alive, your biological age says far more about your health. Biological age is indicated through various biomarkers ranging from the length of telomeres the tips of chromosomes to changes in DNA expression, and even your gut microbiome. Some 55-year-olds may be biologically equivalent to 45, making them more resilient to disease, while others may be far older, due to lifestyle or genetics. Since the 1930s, scientists have identified certain drugs which appear capable of reversing biological ageing in mice. Over the past nine months, the pandemic has provided increasing evidence they may be capable of doing the same in humans. Covid has moved anti-ageing from hope to promise, says Barzilai. The promise is that ageing is flexible, and can be manipulated, is something weve shown again and again in animals. The eight hallmarks of ageing Geroscientists have defined eight hallmarks of biological ageing, which when targeted can improve health and lifespan in animals. These hallmarks range from declining immune function, to a decrease in the quality and quantity of mitochondria the energy factories of our cells and an impaired ability of cells to perform garbage disposal and remove toxins or viruses. There are drugs which can target some hallmarks of ageing, including resveratrol a compound found naturally in foods such as blueberries but the impact of Covid-19 has sparked particular interest in a cheap, commonly available medication called metformin, which has been used to treat diabetes for over fifty years, due to its ability to lower glucose levels. But recently, epidemiologists have begun to notice people taking it for diabetes also appeared to have reduced rates of cardiovascular disease and cancer. When the pandemic began, an early study from a hospital in Wuhan sparked particular interest. It showed diabetics taking metformin were much less likely to die of Covid-19 than diabetics not on the drug. Geroscientists around the world took note. Because of the number of people contracting Covid-19, we could gather data on metformin and its impact on reducing mortality, which would otherwise have taken years to collect, says Vadim Gladyshev, a biochemist at Harvard Medical School. Soon, further studies yielded similar findings. Doctors at the University of Minnesota found metformin lowered mortality rates across more than 6,000 Covid-19 patients with diabetes, albeit only in women. Barzilai believes he understands why. In a paper published earlier this year, he showed that metformin targets all eight hallmarks of ageing at the same time. Now, this accumulation of evidence has helped convince investors to provide $75 million in funding for a landmark randomised control trial called TAME. Intended to begin in June 2021, it aims to see whether giving metformin to older people for four to five years, can give them more years of good health. If this proves successful, it could see metformin licensed by regulators as the worlds first clinically proven anti-ageing therapy. AI recommendations In April, Edwin Lam, a pharmacologist at Thomas Jefferson University, was looking at AI-based predictions of potential Covid-19 treatments and found a drug called rapamycin ranked higher than many highly touted alternatives. Rapamycin is currently used to prevent organ transplant rejection, but geroscientists have been interested in its effects on longevity for decades. It specifically targets a pathway called mTOR, a major driver of many of the cell degradation processes that occur with ageing. Because rapamycin inhibits mTOR, it can help reactivate different parts of the immune system, making them behave like a younger person. Boston-based biotech company resTORbio have previously shown that forms of rapamycin can reduce rates of respiratory infections in over 65s. They are now conducting a clinical trial in the US, looking at whether giving rapamycin to nursing home residents on a daily basis, could protect them from becoming severely infected with Covid-19. If successful, it could pave the way for rapamycin becoming a new treatment for protecting older people from seasonal infections, and future viral outbreaks. New hope for Alzheimers The renewed interest in biological ageing as a result of Covid-19, could also yield benefits for other diseases linked to the ageing process, in particular Alzheimers. For years, pharma companies have attempted to develop treatments which target the accumulation of amyloid proteins in the brain during the course of the disease. With Covid-19 increasing the spotlight on how ageing makes people more vulnerable to disease, Alzheimers scientists have begun to consider alternative approaches. I think neurologists are becoming more open to the idea that we have been too insensitive to the ageing context in which Alzheimers occurs, says Jeffrey Cummings, professor of neurology at UCLA. Most patients have the onset of their disease in their 80s, where you get this accumulation of multiple adverse influences on cognitive function. One particular clue about how to prevent this accumulation may lie in our DNA. As we age, telomeres become shorter, leading to a variety of cell changes. However, in 1984 biologists Elizabeth Blackburn and Carol Greider discovered an enzyme produced in cells called telomerase which naturally prevents telomere shortening, a finding which won them the 2009 Nobel Prize. Telomerase levels also decline with age, but in recent years pharma companies have begun to wonder whether artificially boosting telomerase through drugs, could prevent age-related diseases. Seoul-based pharma company GemVax have developed a product named GV1001 which boosts telomerase levels in cells, with the aim of seeing whether it can prevent decline in Alzheimers patients and prevent the onset of the disease altogether. In a recent Phase II clinical trial of moderate to severe Alzheimers patients, they reported promising results on an assessment tool called the severe impairment battery (SIB) scale. The results exceeded our expectations, said Jay Sangjae Kim, chairman of GemVax. With the major test a Phase III trial which is set to get underway in 2021 still to come, the results must be viewed cautiously, but the success of GV1001 has the potential to yield a new frontier of telomerase based drugs for age related diseases.

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The Nashville bombing suspect sent packages to people across the country containing typed conspiracy theories about September 11 and lizard people,...

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How does the human body react to being in space? – Sciworthy

Thursday, December 24th, 2020

Since 1961, more than 500 humans have flown into space. However, only 20 astronauts have stayed more than 90 days on long-duration space missions. If humans will one day travel to and from Mars, the round-trip will take 3 years. It is essential then, before those crew members ever launch, that we understand the effects long duration spaceflight has on the human body.

This unique environment consists of extreme conditions such as weightlessness, high radiation, variations in extreme temperature and pressure, among other health stressors. Long duration space flight significantly affects astronaut body mass index and what genes are expressed. Changes in metabolism, vascular health, the gastrointestinal microbiome, and cognitive performance were also observed during spaceflight. These adverse effects resolve upon return to earth as astronauts maintain vigorous exercise and nutrition programs for rehabilitation.

To study in depth the changes taking place in the human body over such a long mission in space, researchers need to look at everything from genetics to body mass. Among the Astronaut corps, NASA had a unique opportunity a set of genetically identical twin astronauts, Scott and Mark Kelly. For 340 days, Scott would be on the International Space Station (ISS), while Mark remained on Earth, both undergoing the same medical analyses, pre-flight, in-flight, and post-flight to catalog the changes between the two.

The results were obtained from samples including saliva, stool, skin, urine and blood. Different molecular level techniques, cognitive tests, and biometric tests were used to understand the genetic, physiological and psychological changes in the astronauts.

The astronauts experienced changes in the expression of over 800 genes during spaceflight. Most of the genes returned to normal after flight, but some did not leading to changes in astronauts genetics and physiology. Space radiation may have damaged their DNA.

The midflight flu vaccination administered by the astronauts worked exactly as it does on Earth. This suggests the primary immune system functions were maintained during the flight, and vaccines were still an effective tool for protection.

Genes related to inflammation were more active, which may result from the human body reacting to long duration space flight. Researchers suggest telomeres (a region of DNA at the end of a chromosome) act as an aging clock in every cell, as we grow older our telomeres grow shorter. Telomere elongation was observed in space, but we cannot conclude that space is a miraculous location that adds to human longevity. Elongation may be due to the exercise and calorie-regulation astronauts maintain inflight.

A rapid shortening of telomeres in less than 45 hours was observed upon astronaut return to Earth, likely due to the extreme stresses associated with landing. Mainly the longer telomeres are associated with healthy lifestyle factors such as good nutrition and regular physical activity. However, it is unknown if telomere lengthening and shortening relate to aging in this case, because of the lack of research conducted on telomeres in microgravity.

Spaceflight might have effects on learning and cognition. The in-space astronaut could complete learning and work tasks with greater speed and accuracy, concluding that spaceflight may affect cognition positively.

Bone density is of great concern for space biology researchers. It is well known that spaceflight causes rapid loss of bone density, decreased muscle mass, and weight loss. These are common physiological changes observed in astronauts due to changes in gene and hormone regulation in space. Furthermore, due to microgravity, blood and fluids move from lower to upper body called headward fluid shift causing an appearance of a puffy face and skinny legs. This fluid shift may lead to increased pressure in the veins and capillaries of the eyes causing vision problems in astronauts.

Research also suggests astronauts are at high risk for dehydration, evidenced by changes in the gene AQP2, which regulates water reabsorption in the body and is a useful indicator of hydration status. On the ISS, the isolated and confined environment of the astronauts puts them in a degree of psychological stress. Meanwhile, eating only freeze-dried or heat-stabilized prepackaged food in space is different from what astronauts are used to eating on Earth. These psychological and nutritional stressors in astronauts negatively affect the function of beneficial gut microbes. This change in the gut microbiome results in alterations of immunity, physiology, and even psychological well-being.

The NASA twin study generated unique biomedical data on the effect of a year-long spaceflight on the human body. Most of the biological changes returned to baseline after the 340-day space mission, suggesting that human health can be mostly sustained over this spaceflight duration. As the researchers suggest, the space environment leads to potential health risks. Exercise, a good diet, and personalized medicine will make multi-year space exploration safe for astronauts. These advancements also have the potential to improve Earth medicine as well.

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How does the human body react to being in space? - Sciworthy

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A century and counting: Ardmore woman turned 100 on Friday – Daily Ardmoreite

Thursday, December 24th, 2020

Drew Butler| dbutler@gannett.com

In the evening hours of Saturday, December 18, 1920 a little girl was born in Garvin County. On Friday, December 18, 2020 that little girl, Velma Peery, celebrated her 100th birthday at Canoe Brook Ardmore Assisted Living.

Ive still got a lot of life in me, she said. I can do pretty good, but the more I sit around the stiffer I get.

Her son, Lynn Peery shared a few details about his mothers life. She lived in Garvin County for most of her life until moving into an assisted living facility in Ardmore a little over a decade ago. She was married to her husband for 57 years until his death in 1994, and the couple had four sons and one daughter.

Lynn, at the age of 74, is the baby of the family, and he said four of the five siblings are still living. One of his brothers passed away last year after an infection he developed after a surgery.

He credits his mother's and siblings' longevity with honest living and hard work along with the help of genetics.

My grandparents on her side both passed away in their early 80s, Peery said. On my dads side most of them died in their early 50s. My dad had heart surgery at 54 and we were able to keep him for another 20 years until he passed away at the age of 74.

He shared a story about his mother from the day after his father passed.

When my dad passed away, we went up and spent the night, Peery said. The next morning I got up and made coffee for everybody and took her some. She told me that she didnt like that stuff. I said what do you mean you dont like it? You and dad sat and drank coffee every morning for 57 years! She said well, he liked to talk and drink coffee in the morning, and I never liked it but I did it for him. Talk about dedication!

Peery lives in Ardmore as do several of her grandchildren. He said he visits her through the window almost every day and the entire family is looking forward to when they are able to come inside to visit and take her out for day trips.

She said she feels like a tiger in a cage because she cant get out and everybody is stuck inside, he said. We hope to get to where we can get her out to move around a bit. Were also looking forward to getting in and helping her redo her room once all of this is done.

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A century and counting: Ardmore woman turned 100 on Friday - Daily Ardmoreite

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The Adrenomyeloneuropathy Treatment Market to grow on an emphatic note from 2019 to 2029 – PharmiWeb.com

Thursday, December 24th, 2020

Adrenomyeloneuropathy is a rare genetic neuro-degenerative disease. Adrenomyeloneuropathy is the adult onset of adrenoleukodystrophy caused by the mutation in ABCD1 gene occurs usually in young boys. Adrenomyeloneuropathy disease affect the nerve cells in the spine and brain and the adrenal glands. Adrenomyeloneuropathy symptoms includes stiffness, weakness and pain in the legs. Adrenomyeloneuropathy is also known as progressive spastic paraparesis. Damage to the nerves of the legs which causes unsteadiness and fall, also the bladder, bowel and sexual organs are affected by the adrenomyeloneuropathy. Rare diseases affect vast numbers of people, with current data representing 30 million sufferers in the EU alone and 30 million affected in the US. There is no cure to Adrenomyeloneuropathy. However some treatment might stop the progression of Adrenomyeloneuropathy such as stem cell transplants. Blood testing, MRI test, vision screening and Skin biopsy and fibroblast cell culture are done for the diagnosis for the adrenomyeloneuropathy. Continued advances in the treatment of adrenomyeloneuropathy will further propel the adrenomyeloneuropathy treatment market.

Growing cases of rare disease and development of new and advanced treatment for rare disease is expected to boost the adrenomyeloneuropathy treatment market. Growing preference for healthy lifestyle and favorable government regulation spur the Adrenomyeloneuropathy treatment market in the forecast period. Development of new technology and devices for the diagnosis of genetic disorders will propel the adrenomyeloneuropathy treatment market. Rising focus on the research and development of new therapeutic and drug treatment and growing government funding for the orphan drug is expected to drive the adrenomyeloneuropathy treatment market.

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However, stringent regulations for the drug development and high cost of associated with the treatment is expected to hinder the adrenomyeloneuropathy treatment market.

The global adrenomyeloneuropathy treatment market is segmented on basis of disease type, drug type and end user and geography.

Development of novel drugs and undergoing clinical trial for the rare disease is expected to boost adrenomyeloneuropathy treatment market. More than 3,000 drugs are in active development for one of the rare disease. Progress in genomics and biomedical science for the development of rare disease drug is expected to spur the adrenomyeloneuropathy treatment market. Various pharmaceutical companies are focusing on developing drug for the low prevalence disease types and rising funding and collaboration among the key players and government is expected to spur the adrenomyeloneuropathy treatment market.

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The North America market for adrenomyeloneuropathy treatment is expected to retain its dominance, owing to increasing patient pool for rare disease, increasing government funding to accelerate the research and development for rare disease. According to Genetic and Rare Diseases Information Center, more than 25 million Americans are suffering from rare disease in United States.Europe is expected to account for the second largest share in the global adrenomyeloneuropathy treatment market owing to growing clinical trial funding programs for orphan drug development and high prevalence of adrenomyeloneuropathy and high treatment seeking rate. Asia Pacific is expected to show significant growth, owing to increasing diagnosis rate and improvement in healthcare infrastructure. China is expected to show significant growth in the adrenomyeloneuropathy treatment market, due to rising population improving R&D capability, increasing per capita heath spending. Latin America and Middle East & Africa is expected to show growth owing to lack of diagnosis and inadequate healthcare facilities and lack of skilled physicians for Adrenomyeloneuropathy Treatment market.

Examples of some of the key manufacturer present in the global adrenomyeloneuropathy treatment market are Ascend Biopharmaceuticals, Novadip Biosciences, Eureka Therapeutics, Human Longevity, Regeneus, Allogene Therapeutics, BioRestorative Therapies, Immatics Biotechnologies, NewLink Genetics, Cytori Therapeutics, Talaris Therapeutics among others.

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The Adrenomyeloneuropathy Treatment Market to grow on an emphatic note from 2019 to 2029 - PharmiWeb.com

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Getting to the root of why hair goes gray – messenger-inquirer

Thursday, December 24th, 2020

Marco Kaltofen was 11 when he noticed his first white hairs. As his hair grew whiter, his middle-school friends started calling him the professor. By his mid-30s, it was completely white, as it had been for three of his grandparents. His parents went white in their 40s, so I had no chance of avoiding this, Kaltofen says.

Now 61, he is a civil engineer who lives in Boston. He wears his white hair in a ponytail. White hair is part of my identity, and I am completely at peace with it, he says.

Then there is Joe Rees, 75, a retired customs attache who lives in Washington. He is balding, but the hair that remains on the sides and in the back is the same dark brown it always has been. He jokingly attributes this to clean living and a pure heart, although, like Kaltofen, it probably is genetic. His mothers black hair didnt start to go gray until she was in her 70s, and was 50/50 when she died at 88, he says.

Still, Id rather be gray than bald, he says. That way, I wouldnt have to worry about wearing a hat all the time.

To be sure, Rees and Kaltofen are exceptions, since most people start graying in their 50s and 60s. Nevertheless, their experiences are among the many mysteries of gray, white or silver-looking hair that scientists are exploring to learn more about aging. They want to know why some people turn gray early and others late or not at all and what this might signal about their health. They also want to understand the factors that hasten graying, and even whether gray hair is reversible which could be a boon to those allergic to hair dye, or who hate spending money to keep the gray away.

Most important, studying gray hair could point to new approaches in promoting healthier aging, says Candace Kerr, health scientist administrator in the National Institute on Agings Division of Aging Biology.

While graying is one of the markers of aging aging is the ultimate risk factor for why hair goes gray it highlights the need for better understanding of the mechanisms that drive aging and age-related diseases, she says. To be able to target these pathways will be critically important for our aging population to live longer and happier lives.

Hair that looks gray, white or silver actually is colorless. Hair color comes from melanin, a pigment produced by cells in the hair follicles. Over time, these cells suffer damage and become depleted, losing their ability to make melanin. This results in new hair without pigment meaning, no color.

People use gray, white and silver interchangeably to describe hair that is turning or has turned. Its appearance whether it looks, gray, white or silver depends on how much natural color, or pigment, remains, experts say. Hair that has lost all its color typically appears white.

Studies have identified a number of factors that also may speed up gray hair, including smoking, diet, stress and genetics.

Our hair color depends on a set of specialized stem cells called melanocyte stem cells, and every time a new hair grows, these melanocyte stem cells have to divide in two and make a new melanocyte, [or] pigment cells, explains Melissa Harris, assistant professor of biology at the University of Alabama at Birmingham. These pigment cells stay in the base of your hair and their job is to produce pigment. These melanocytes reach out skinny arms, called dendritic processes, that shuttle the pigment to the hair shaft as it grows. So if all your melanocyte stem cells disappear, so do your melanocytes and so does your hair pigment. Thus gray hair.

Because stem cells directly influence hair color, studying gray hair can provide insights about why stem cells age and ultimately fail, offering important clues about the workings of other stem cells in the body for example, those found in muscles, bones and organs. In turn, these ultimately could point to whether gray hair could be a marker for disease, or the opposite, a longer life. Previous studies have not shown a relationship between life span and gray hair, including whether late onset of gray hair predicts longevity. Some research, however, indicates that gray or white hair can be a sign of early heart disease, regardless of age.

In some people, gray hair could potentially serve as indication of their health for instance when caused by stress, or a signal for those who may be developing cardiovascular disease, Kerr says. We still need to learn more about whether and, if so, how late onset of gray hair can signal better health and longevity in some people under certain circumstances, as well as whether early graying means stem cells might be aging.

There are many different stem cells in our body which may or may not age by different means, she says. How stem cells mark aging overall and how they could interact to promote aging is an important question.

This is why scientists who study gray hair regard it as a valuable research tool.

As gray hair researchers, we often have to defend why we study a cosmetic characteristic, rather than a life-threatening disease, Harris says. But what is very cool about gray hair from a scientific point of view is that we can see it with our own eyes, meaning we dont have to take invasive biopsies, and it doesnt kill you. We have asked a lot of important and interesting questions about stem cells by studying gray hair in mice. And, we are constantly on the lookout for gray-haired mice so we can use our scientific skills to find out what makes them gray.

A 2018 mouse study by Team Hair-Us (Harris nickname for her lab colleagues) found a connection between MITF (microphthalmia), a transcription factor (a protein involved in gene expression) important in managing pigment production, and the innate immune system, suggesting that some peoples hair may turn gray in response to serious illness or chronic stress. They discovered a relationship between genes involved in hair color and those that trigger an immune response to a viral infection, suggesting this interaction could increase the chances of developing gray hair.

MITF, in a sense, shields melanocyte stem cells from our own immune system, she says. Normally our immune system protects our bodies from infection. But for melanocyte stem cells, too much immune response is bad for their health, and this leads to their loss and to gray hair. Why melanocyte stem cells are so sensitive to our own natural means for protection, we still dont know.

Im very curious to see whether we see an uptick in individuals with gray hair due to coronavirus infection, she says. Unfortunately, we probably wont know because gray hair is rarely documented clinically, unless it is very extreme.

Scientists still dont know why some people turn gray early, late, or not at all, although they suspect genes, nutrients and possibly the immune system play a role in depleting melanocyte stem cells.

There is still much to learn about what regulates these stem cells and what may contribute to their loss, says Ya-Chieh Hsu, associate professor of stem cell and regenerative biology at Harvard University and principal faculty member of the Harvard Stem Cell Institute.

Among other things, Hsu studies the effect of stress on graying. Most of us are familiar with those before-and-after photographs of U.S. presidents most recently Barack Obama showing a striking increase in gray hair during their terms, even in relatively young presidents. Its known as the Marie Antoinette Syndrome, after the 18th-century French queen whose hair allegedly turned white overnight before she went to the guillotine and her death at age 38 during the French Revolution.

With the aging process, we gradually lose melanocyte stem cells one-by-one over a very long period of time, Hsu says. What we found in our research was that the stress can accelerate that process.

Hsu and her colleagues found that stress stimulates the same nerves that trigger the fight-or-flight response, which in turn causes permanent damage to the pigment-producing cells in hair follicles. The fight or flight response is thought to be a good thing in stressful situations because it can drive us and other organisms to respond to danger rapidly, Hsu says. This activation causes a spike in the neurotransmitter norepinephrine. Norepinephrine raises our heartbeat and allows us to react quickly to danger without having to think about it.

But norepinephrine also tells melanocyte stem cells to pump up their activity and proliferate, and too much norepinephrine, in this case triggered by stress, causes the melanocyte stem cells to burst into so much activity it leads to rapid depletion of the stem cell reservoir, she says. If all the stem cells are depleted, no more pigment-producing cells can be produced anymore, and the hair turns gray.

Other stress hormones, ACTH (adrenocorticotropic hormone) for example, can cause melanocyte stem cells to migrate away from the hair follicle before they can produce the melanocytes needed for hair and skin color, according to research. Such hormones are known to increase in the body after stress, and may have the potential to promote the loss of these cells, regardless of age, says study author Mayumi Ito, associate professor in the departments of cell biology and dermatology at the New York University Grossman School of Medicine.

Hsu believes the connection between stress and hair color could reveal additional information about how stress affects other biological processes. How stress affects our tissues is still poorly understood, and one of the powerful aspects about the melanocyte is that it provides a visible and highly trackable system to study stress, she says.

Ito also found that certain cell signaling proteins called endothelins (substances known to constrict blood vessels and raise blood pressure) bind to melanocyte stem cells and, in doing so, keep them healthy. Interrupting the process causes cell loss and early graying in mice. They are studying whether the same happens in human hair follicles, hoping to find ways to preserve or regenerate the key stem cells that give hair its color.

All of this raises the intriguing possibility that scientists could discover ways to prevent or reverse gray hair.

Team Hair-Us recently published a paper describing a topical drug combination that increased melanocyte stem cells in gray mice, ridding them of their gray and restoring their original fur color perhaps for good. Because the treatment originally developed to regrow hair replenished pigment-producing stem cells, the effects could be long-lasting, Harris says.

We didnt keep the mice forever so we dont know, says Harris, who plans more studies. This has made us very interested in whether gray hair really is permanent, and if we can do something about it. We really want to know and so does everyone else we talk to is whether and when we can bring this to humans.

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Getting to the root of why hair goes gray - messenger-inquirer

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Which countries have the highest life expectancy in Europe? – World Economic Forum

Thursday, December 17th, 2020

In this world nothing can be said to be certain, except death and taxes, as Benjamin Franklin remarked. But just as tax rates differ depending on the jurisdiction, so life expectancy varies across borders.

As the chart below shows, there are big gaps in longevity even between the relatively affluent countries of Europe, where a Spanish woman can expect to live more than 16 years longer than a Latvian man.

Life expectancy varies greatly access Europe's different economies.

Image: OECD

So what makes some countries more conducive to a long life than others?

What people eat is a major factor. Long life is more common in places where the Mediterranean diet is the norm, such as Spain, Italy and Cyprus. Numerous scientific studies have proved the benefits of the typical Mediterranean diet: high in vegetables, fruits, nuts, olive oil and fish, and low in meat (especially red meat) and most dairy products. The combination reduces the risk of strokes and heart attacks, the two biggest killers worldwide. At the other end of the scale, there is a much higher incidence of heart and circulatory diseases in Eastern Europe, the Balkans and the Baltic states.

Health spending also plays a significant role. Switzerland and the Scandinavian countries spend three or four times the amount of money per capita on healthcare than the average in Eastern Europe. This mirrors the situation in the rest of the world, where there is a strong correlation between health and wealth.

Each year, $3.2 trillion is spent on global healthcare making little or no impact on good health outcomes.

To address this issue, the World Economic Forum created the Global Coalition for Value in Healthcare to accelerate value-based health systems transformation.

This council partners with governments, leading companies, academia, and experts from around the world to co-design and pilot innovative new approaches to person-centered healthcare.

Other factors that can affect longevity include lifestyle choices such as alcohol consumption and smoking, environmental issues like air pollution, and genetics. In every country, women tend to live significantly longer than men, with the biggest gaps in the Baltic states, and the smallest in the Netherlands.

A long life doesnt necessarily mean a healthy old age, as the chart below demonstrates.

Life expectancy and healthy life years at birth, by gender, 2018 (or nearest year)

Women are expected to live longe than men.

Image: OECD

For example, both men and women in Bulgaria are healthy and active for longer than in Portugal, even though their overall life expectancy is less. As more nations have ageing populations, getting more out of later life is becoming an increasingly important challenge.

Alzheimers Diesease, a result of rapid ageing that causes dementia, is a growing concern. Dementia, the seventh leading cause of death worldwide, cost the world $1.25 trillion in 2018, and affected about 50 million people in 2019. Without major breakthroughs, the number of people affected will triple by 2050, to 152 million.

To catalyse the fight against Alzheimer's, the World Economic Forum is partnering with the Global CEO Initiative (CEOi) to form a coalition of public and private stakeholders including pharmaceutical manufacturers, biotech companies, governments, international organizations, foundations and research agencies.

The initiative aims to advance pre-clinical research to advance the understanding of the disease, attract more capital by lowering the risks to investment in biomarkers, develop standing clinical trial platforms, and advance healthcare system readiness in the fields of detection, diagnosis, infrastructure and access.

There is a caveat to the data in the OECD report: it all predates the COVID-19 pandemic. Until 2018, life expectancy had been increasing across the EU, although more slowly in recent years. It is possible that in the worst-hit countries, among them Spain and Italy, 2020 could see a decline in life expectancy for the first time in decades.

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Which countries have the highest life expectancy in Europe? - World Economic Forum

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