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Archive for the ‘Longevity Genetics’ Category

Taking years off your age? This Israeli expert says its all up to you – Haaretz

Monday, November 7th, 2022

Taking years off your age? This Israeli expert says its all up to you  Haaretz

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Taking years off your age? This Israeli expert says its all up to you - Haaretz

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Joris Deelen to present at the 9th Aging Research & Drug Discovery Meeting 2022 – EurekAlert

Saturday, April 2nd, 2022

image:The ARDD Meeting 2022 will be hosted on August 29 - September 2, 2022 view more

Credit: Insilico Medicine Hong Kong Limited

March 31, 2022 -- Joris Deelen, Ph.D., will present the latest research on the topic Identification and functional characterisation of genetic variants linked to human longevity at the worlds largest annual Aging Research and Drug Discovery conference (9th ARDD). Dr. Joris Deelen is the Research Group Leader at the Max Planck Institute for Biology of Ageing.

"Previous research on the genetics of human longevity has shown that this trait is likely mainly determined by rare genetic variants. Therefore, the work in my group is currently focused on the functional characterisation of rare genetic variants identified in long-lived individuals. I recently obtained an ERC Starting Grant and a Longevity Impetus Grant to support this work." said Joris Deelen, Ph.D., Research Group Leader at the Max Planck Institute for Biology of Ageing.

Joris Deelen obtained his Ph.D. at the Leiden University Medical Center in the Netherlands in2014. In 2016, he joined the Max Planck Institute for Biology of Ageing as a postdoctoralresearcher where he was promoted to Research Group Leader in 2020. The work in his groupfocusses on the establishment of novel human aging studies in Cologne to determine theefficacy of previously identified biomarkers of aging in clinical studies. The main focus is onbiomarkers that have been identified in large-scale international collaborations of human studies using omics-based approaches, such as metabolomics.

The conference proceedings of the ARDD are commonly published in peer-reviewed journals with the talks openly available at http://www.agingpharma.org. Please review the conference proceedings for 2019, 2020 and 2021https://www.aging-us.com/article/203859/text .

Aging is emerging as a druggable condition with multiple pharmaceuticals able to alter the pace of aging in model organisms. The ARDD brings together all levels of the field to discuss the most pressing obstacles in our attempt to find efficacious interventions and molecules to target aging. The 2022 conference is the best yet with top level speakers from around the globe. Im extremely excited to be able to meet them in person at the University of Copenhagen in late summer. said Morten Scheibye-Knudsen, MD, Ph.D., University of Copenhagen.

Aging research is growing faster than ever on both academia and industry fronts. The ARDD meeting unites experts from different fields and backgrounds, sharing with us their latest groundbreaking research and developments. Our last ARDD meeting took place both offline and online, and it was a great success. I am particularly excited that being a part of the ARDD2022 meeting will provide an amazing opportunity for young scientists presenting their own work as well as meeting the experts in the field. said Daniela Bakula, Ph.D., University of Copenhagen.

Many credible biopharmaceutical companies are now prioritized aging research for early-stage discovery or therapeutic pipeline development. It is only logical to prioritize therapeutic targets that are important in both aging and age-associated diseases. The patient benefits either way. The best place to learn about these targets is ARDD, which we organize for nine years in a row. This conference is now the largest in the field and is not to be missed, said Alex Zhavoronkov, Ph.D., founder and CEO of Insilico Medicine and Deep Longevity.

Building on the success of the ARDD conferences, the organizers developed the Longevity Medicine course series with some of the courses offered free of charge at Longevity.Degree covered in the recent Lanced Healthy Longevity paper titled Longevity medicine: upskilling the physicians of tomorrow.

About Aging Research for Drug Discovery Conference

At ARDD, leaders in the aging, longevity, and drug discovery field will describe the latest progress in the molecular, cellular and organismal basis of aging and the search for interventions. Furthermore, the meeting will include opinion leaders in AI to discuss the latest advances of this technology in the biopharmaceutical sector and how this can be applied to interventions. Notably, this year we are expanding with a workshop specifically for physicians where the leading-edge knowledge of clinical interventions for healthy longevity will be described. ARRD intends to bridge clinical, academic and commercial research and foster collaborations that will result in practical solutions to one of humanity's most challenging problems: aging. Our quest? To extend the healthy lifespan of everyone on the planet.

About Scheibye-Knudsen Lab

In the Scheibye-Knudsen lab we use in silico, in vitro and in vivo models to understand the cellular and organismal consequences of DNA damage with the aim of developing interventions. We have discovered that DNA damage leads to changes in certain metabolites and that replenishment of these molecules may alter the rate of aging in model organisms. These findings suggest that normal aging and age-associated diseases may be malleable to similar interventions. The hope is to develop interventions that will allow everyone to live healthier, happier and more productive lives.

About Deep Longevity

Deep Longevity has been acquired by Edurance RP (SEHK:0575.HK), a publicly-traded company. Deep Longevity is developing explainable artificial intelligence systems to track the rate of aging at the molecular, cellular, tissue, organ, system, physiological, and psychological levels. It is also developing systems for the emerging field of longevity medicine enabling physicians to make better decisions on the interventions that may slow down, or reverse the aging processes. Deep Longevity developed Longevity as a Service (LaaS) solution to integrate multiple deep biomarkers of aging dubbed "deep aging clocks" to provide a universal multifactorial measure of human biological age. Originally incubated by Insilico Medicine, Deep Longevity started its independent journey in 2020 after securing a round of funding from the most credible venture capitalists specializing in biotechnology, longevity, and artificial intelligence. ETP Ventures, Human Longevity and Performance Impact Venture Fund, BOLD Capital Partners, Longevity Vision Fund, LongeVC, co-founder of Oculus, Michael Antonov, and other expert AI and biotechnology investors supported the company. Deep Longevity established a research partnership with one of the most prominent longevity organizations, Human Longevity, Inc. to provide a range of aging clocks to the network of advanced physicians and researchers. https://longevity.ai/

About Endurance RP (SEHK:0575.HK)

Endurance RP is a diversified investment group based in Hong Kong currently holding various corporate and strategic investments focusing on the healthcare, wellness and life sciences sectors. The Group has a strong track record of investments and has returned approximately US$298 million to shareholders in the 21 years of financial reporting since its initial public offering. https://www.endurancerp.com

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Joris Deelen to present at the 9th Aging Research & Drug Discovery Meeting 2022 - EurekAlert

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Herd genetics begins with the bull | Agriculture | victoriaadvocate.com – Victoria Advocate

Saturday, April 2nd, 2022

Texas is a huge beef state. In fact, it is one of the leading beef-producing states in the country. Right here in Victoria County alone, we have about 60,000 mother cows in production that add about $30 million to the agricultural income. All these mother cows require the right genetics to produce and achieve herd goals.

Many folks overlook the importance of bull genetics, and selection is crucial for herd genetic success. You cant tell everything you need to know about a bull just by looking at him. There are more tools than ever at your disposal in the beef industry. We will explore just a few in this article.

When looking for a new herd sire, many bull buyers get lost in all the data and acronyms that go along with selling purebred bulls today. In the past, most buyers evaluated bulls just by looking at them or by comparing them with other bulls in the pen. Today, bull breeders have a lot more data to offer buyers who want it, in addition to those who still like to just look.

Initially, that data included birth, weaning and yearling weight, adjusted for the sex of the calf; since males are heavier, and for the age of dam, due to the influence of milk production higher in older cows, lower in younger ones. Similarly, records on other traits such as carcass, fertility, longevity and docility were also collected.

About 60 years ago, it was realized that bulls and females could be evaluated for their actual genetic value in these traits. Each animal in the breed could be selected on their true genetic merit. These values were called Expected Progeny Differences or EPD. The EPD is calculated for each trait and for each animal in the breed. The EPD is reported in the units of the trait measured, for example pounds for weight. Each EPD also has an accuracy value that tells you how close the EPD really is to the animals true genetic value. It has made accurate selection to improve performance very easy.

Using DNA, beef cattle geneticists have been using genetic markers to improve the accuracy of the EPDs from young animals, especially young bulls, so that they can be selected earlier for traits of importance. They are called Genomic EPD or GE-EPD. Now, even young animals can be selected and used reliably to improve our genetics. This earlier selection also reduces bull development costs since the better bulls are identified earlier and more average and below average bulls are culled. Selecting younger bulls will improve selection success by reducing the amount of time between when a bull is selected for breeding and his calves actually hit the ground.

Select bulls using EPDs to improve traits that are of economic value to your operation. Select bulls that have a good health program and have passed a breeding soundness examination.

For more information, please call the Victoria County Extension Office at (361) 575-4581.

Matt Bochat is a County Extension Agent Ag/Natural Resources Victoria County Texas A&M Agrilife Extension.

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LeBron James Can Become The GOAT: He Surpassed Michael Jordan In Almost Every Category Except Championships, MVP Awards And Finals MVPs – Fadeaway…

Saturday, April 2nd, 2022

LeBron James has had a spectacular individual season, despite what his team record states at the moment. The Lakers are well under .500 and are at massive risk for missing the play-in tournament, which is their only chance at making the playoffs. For a player at age 37, the goal would be to win at least one more championship before returning. But LeBron James is no ordinary player, and certainly no ordinary 37-year-old.

The King already has 4 NBA championships to his name, and even if he does not win another one, he is already one of the top-5 players to have ever played the game. After all, look at his incredible career. James has won 4 titles, 4 Finals MVPs, 4 MVPs, and made a spectacular 18 All-Star appearances. No player has been great for as long as LeBron has, a testament to his ability to take care of his body and also his almost inhuman genetics.

As a result, LeBron James is considered the single greatest player of all time to much of the younger audience. While Michael Jordan tends to dominate the GOAT debates, LeBron James certainly has his supporters, and for good reason. Recently, we saw LeBron James pass Karl Malone to become the 2nd greatest scorer in NBA history. He is getting closer to Kareem Abdul-Jabbar at the top spot, and he will likely pass the legendary center next year.

If LeBron James becomes the all-time leading scorer, his status in the GOAT debate greatly increases and he might have an even stronger argument for being the greatest player ever, and here are the reasons why.

Other than LeBron James, Kareem Abdul-Jabbar is the name most mentioned when discussing the greatest challenges to Micahel Jordans throne as the GOAT. While his 6 NBA titles and 6 MVPs are his greatest achievements, the fact that he is the all-time leading scorer tends to boost him in the rankings. For LeBron James, having his name etched in record books for being the all-time leading scorer is the single greatest advertisement for the legendary player.

The reason is simple. Even for the millions of people who are not aware of professional basketball, seeing LeBron James holding the number one spot among all-time scorers would convince them that he is the greatest ever without looking into details. Of course, LeBrons career is also backed up with other extraordinary achievements. Shaquille ONeal mentioned it himself, if and when LeBron James becomes the all-time leading scorer in NBA history, he should be considered the GOAT.

As reported, Shaquille O'Neal says LeBron James can become the GOAT if he surpasses Kareem Abdul-Jabbar on the all-time scoring list:

Hes got four rings and he becomes the highest scorer in the NBA history. Hes the best ever, ONeal said. Aint nothing you can say.

Shaq continued:

I know what hes doing, ONeal said while eating some roast beef. Championships are great, but hes trying to pass Kareem up. Thats what he is doing. I know exactly what hes doing. Cause now if you pass Kareem up, it aint no talk about who the best player ever is.

Basketball is about scoring more points than the opponent, and if LeBron did that better than everyone else, he will convince millions of people he is the GOAT.

No player in NBA history has played so well for so long as the great LeBron James. The King is in his 19th season and is averaging the third-most points of his career at age 37. James is not only an elite scorer and passer but always seems to find ways to dominate a game and control the outcome. Most pundits and fans refer to Kareem Abdul-Jabbar as the man who played so well into his late 30s and early 40s, but LeBron James has surpassed him in that regard.

The King always seems to find a way to have his name in the record books and is also competing for the scoring title alongside Joel Embiid and Giannis Antetokounmpo. LeBron is somehow playing as if he is 10 years younger on the offensive end of the court, and is putting up spectacular performance after spectacular performance. We will never see the likes of LeBron James again, and his incredible longevity keeps boosting his status in the eyes of casual fans and younger audiences who are becoming more aware of professional basketball.

LeBron James becoming the all-time leading scorer would be a great thing for his career, because it will give him an amazing addition to an untouchable resume. James has 4 NBA titles and 4 Finals MVPs with 3 teams, the only player to ever achieve that. He will also become the all-time leading scorer and the only player in the exclusive 10k points, 10k assists, and 10k rebounds club. James also has 4 MVP awards (tied for 3rd most) and 18 All-Star appearances (tied for 1st alongside Kareem Abdul-Jabbar).

The King also has 17 All-NBA appearances which will be 18 by the end of the year, which is already the most in NBA history. Adding in a scoring title, and possibly a second one coming this year, LeBron is in a league of his own when it comes to longevity awards and accolades. Even if LeBron James played so long at such a high level, he has somehow dominated the game better than everyone else at his age and experience level.

It will also be extremely impressive if James is able to capture his second scoring title at age 37, along with the all-time record next year. LeBron is not considered a natural scorer, yet still broke records by scoring the ball at an elite level at his age and breaking the record for most points scored. LeBron has also spoken about how he feels disrespected as an all-time great scorer during an episode of The Shop:

When they talk about the best scorers of all time, they never mention my name, James said during the shows episode. It pisses me off.

Clearly, James is not happy bout being disrespected as a scorer, even if he is one of the most unselfish superstars ever:

Im not like a natural scorer, James explained. I love getting my guys involved, Ive always been that way.

The King can also find solace in the fact that by breaking the all-time scoring record, his name will have to be mentioned alongside Michael Jordan, Kobe Bryant, and Kareem Abdul-Jabbar as the most dominant scorer ever whether he is naturally inclined to score or not.

To many fans, especially the younger audiences, LeBron James is already the GOAT without the all-time record in points scored. But capturing that record would convince many more people that we are witnessing the best player ever because that is yet another unbreakable record to his name. Being 1st in points scored, 1st in All-NBA selections, 2nd in All-Star selections, 2nd in Finals MVP awards, and 3rd in MVP awards is truly astonishing because he is in a league of his own.

Even if there are people who are not convinced that James is the GOAT, there is no doubt a lot of them will admit that The King will surpass a ton of competitors such as Kareem Abdul-Jabbar once he claims the scoring record. As mentioned, Kareem Abdul-Jabbar is the name most mentioned when discussing the greatest challenges to Micahel Jordans throne as the GOAT. Kareems all-time scoring record tends to boost him in the rankings, an achievement that will firmly belong to James. With Kareem out of the way, there is only one man standing in James way before becoming the GOAT, Michael Jordan.

Obviously, Michael Jordan did not play as long as LeBron James. The Chicago Bulls legend missed out on 4 NBA seasons due to 2 separate retirement phases, and he even only played 17 games following his first season back from his first retirement. That meant, Jordan only had 12 NBA seasons where he was playing consistent basketball at a professional level. That is way off the 19 seasons that LeBron has played, which is why he fails to compare in many of the longevity accolades.

James has more All-Star appearances (18 vs. 14), more All-NBA appearances (17 vs. 11), and is also a greater all-time scorer. These accolades are hard to argue against because it shows LeBron James had a longer sustained career than the legendary Bulls guard. Of course, Jordan supporters will be quick to point out that James does not have as many championships and Finals MVPs as Jordan (6 vs. 4).

While James will likely never catch Jordan in championships won, he has surpassed him in almost every other individual category pertaining to longevity. He is not the scorer that Jordan is as a purely offensive weapon (Jordan has 10 scoring titles), but James has more total points scored and more total stat totals including assists and rebounds. While there will be a massive portion of the NBA fanbase who will prefer Jordans 6 NBA titles, LeBrons scoring record adds yet another unbreakable record to The Kings name.

LeBron James: 4

Michael Jordan: 6

There arent many winners better than Michael Jordan, as he ranks 6th all-time in championships won as a player. Of course, he always performed on the brightest stage of them all and it is likely that LeBron James will never catch Jordan. The King does have 4 titles with 3 teams, meaning he had to move around the league a few times to win them.

LeBron James: 4

Michael Jordan: 6

With Jordan being the best player in every Finals series he played in, he has the edge in Finals MVPs as well. MJ dominated the Finals, never competing in a Game 7 and killing off the competition in 6 games and less. LeBron was also the best player in the series he played in, capturing 4 Finals MVPs in his Finals appearances, although he holds a poor 4-6 record.

LeBron James: 4

Michael Jordan: 5

LeBron James probably should have won more MVP awards, because he is arguably the greatest regular-season player considering his statistics and accolades. The same could be said for Michael Jordan because he was arguably the best player in the league by the end of his first season. James cuts it close, but once again, MJ has the nod in another accolade.

LeBron James: 0

Michael Jordan: 1

LeBron James was an elite defender in his prime, showcasing his talent on the defensive end when he played for the Miami Heat alongside two other All-Stars. Thanks to the presence of Dwyane Wade and Chris Bosh, James was able to focus on defense a little bit more and could defend all five positions when asked to. But he is not Michael Jordan on defense, and quite frankly, very few are. Jordan captured the elusive Defensive Player of the Year award while James has not.

LeBron James: 1

Michael Jordan: 10

LeBron James could earn the scoring title this year, a great achievement for a pass-first player as he will join the likes of Kobe Bryant, Shaquille ONeal, and Carmelo Anthony with two. But he is well off of Jordans 10 scoring titles, and nobody except Wilt Chamberlain (7) comes close. We will never see a dominant scorer like Mike again, and he has the edge over The King.

LeBron James: 18

Michael Jordan: 14

LeBron James has had a longer career and is the greatest 37-year-old player ever. No player has played as great for as long as LeBron, and he has a whopping 18 All-Star appearances. Only Kareem Abdul-Jabbar has more with 19. Jordan had 14 All-Star appearances, a respectable number, but he did not play as long as The King.

LeBron James: 17

Michael Jordan: 11

LeBron James will likely make his 18th All-NBA Team appearance this season, and he is already in a league of his own. Kobe Bryant, Tim Duncan, and Kareem Abdul-Jabbar all have 15 All-NBA appearances, meaning James is the leading man by far. Jordan only has 11 All-NBA appearances, mainly because he did not last 19 seasons at a superstar level as LeBron did. James has the nod in a very important category here.

LeBron James: 6

Michael Jordan: 9

LeBron was a defensive beast in his prime, but he never really had sustained excellence on that end of the floor as MJ did. Jordan made 9 All-Defensive Teams, and only 5 players had more (Tim Duncan, Kevin Garnett, Kobe Bryant, Kareem Abdul-Jabbar, and Scottie Pippen). Once again, James was excellent defensively but Jordan was the better defender.

LeBron James: 3

Michael Jordan: 3

LeBron James is one of the greatest All-Star Game performers, capturing the MVP award 3 times. Michael Jordan also captured the All-Star Game MVP 3 times, meaning he and LeBron James are tied for 2nd all-time with Oscar Robertson and Shaquille ONeal joining them. Only Kobe Bryant and Bob Pettit are ahead of them with 4 awards.

LeBron James: 1

Michael Jordan: 1

LeBron James had one of the best rookie seasons ever, considering the extreme pressure on The King. At age 19, James dropped averages of 20.9 PPG, 5.5 RPG, and 5.9 APG and certainly met expectations by winning Rookie of the Year. Jordan also won Rookie of the Year, posting sublime averages of 28.2 PPG, 6.5 RPG, and 5.9 APG. No doubt, Jordan had the better rookie season.

LeBron James: 37,024

Michael Jordan: 32,292

Michael scored over 32k points in his career and did the bulk of the damage during his incredible 13-year span before his second retirement. Had he played longer without missing nearly 5 seasons with retirement, Jordan could have broken Kareem Abdul-Jabbars record. But LeBron has played longer and has been at an elite level for 19 seasons, as he has more points than MJ.

LeBron James: 10,202

Michael Jordan: 6,672

The King is a 69 behemoth so it is natural for him to have more total rebounds than Michael Jordan. James has a career average of 7.5 RPG, ahead of Michael Jordans average of 6.2 RPG. Over 19 seasons, James has accumulated over 10,000 rebounds as he is part of the exclusive 10k points, 10k rebounds, and 10k assists club. Michael had over 6,000 rebounds in his own career but falls short of James.

LeBron James: 10,041

Michael Jordan: 5,633

As one of the most talented passers ever and a natural playmaker, LeBron James has almost doubled the number of assists as MJ. The King is a pass-first player and is among the best floor generals to have ever played the game. MJ hardly had any weaknesses as a player, but his playmaking is the closest to a weakness. Not because he could not pass, but because he was a natural scorer with the ability to take every shot down the floor.

LeBron James: 2,135

Michael Jordan: 2,514

LeBron James trails Michael Jordan in total steals because the legendary Bulls guard had a career average of 2.3 SPG. James held a career average of 1.6 SPG, and despite playing longer, he could not generate more steals than MJ. Jordan is one of the best defenders ever, so this comes as no surprise.

LeBron James: 1,041

Michael Jordan: 893

LeBron James, as a forward with a large frame, blocked over 1,000 shots in his career. That is an amazing number for a non-big man because ball-handlers are often not known for their shot-blocking ability. Amazingly enough, Michael Jordan was not far off LeBrons total blocks despite playing fewer games and fewer seasons.

LeBron James: 4,782

Michael Jordan: 2,924

Since LeBron James is a pass-first player who handles the ball on almost every possession, it is natural for him to have over 4,000 turnovers. After all, James ranks 1st all-time in turnovers but shares the top-5 with Karl Malone, John Stockton, Russell Westbrook, and Kobe Bryant who were/are ball-dominant stars. Jordan has a lot of turnovers, but LeBron has many more.

LeBron seems to have the edge over Michael Jordan in terms of longevity related accolades including total statistics and more All-Star and All-NBA Teams. But in terms of prime talent and dominance, it is hard to argue LeBron over Jordan.

Michael won more with the Bulls, staying with one team for his career. James had to move a few times to win his titles and often had the deck stacked in his favor. Jordan also seems to have a heavier weight towards his accolades as he has more championships, Finals MVPs, MVPs, scoring titles, and a Defensive Player of the Year.

LeBrons individual statistics will always be greater than Jordans because of his incredible longevity but Mike will find solace in the fact that he always prioritized winning over statistics.

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InsideTracker x Apple Watch, Better Paired Together to Deliver Personalized Health Insights, Science-Backed Guidance for Human Optimization – PR…

Saturday, April 2nd, 2022

Brings blood biometrics, DNA insights together with activity, heart rate, sleep data from Apple Watch to provide personalized nutrition, lifestyle Action Plan

CAMBRIDGE, Mass., March 29, 2022 /PRNewswire/ -- InsideTracker, the leading truly personalized performance and nutrition system, today announced the availability of Apple Watch integration on its top-performing iOS personalized health app. By bringing together blood biometrics, DNA insights and Apple Watch data including workouts, daily activity, resting heart rate (RHR) and sleep duration, the InsideTracker app delivers sophisticated, science-backed nutrition and lifestyle recommendations never before available in real-time, right to Apple Watch devices.

Key Features

The Deepest Understanding from the Inside OutExercise, RHR and sleep directly affect biomarker levels. With InsideTracker's Apple Watch integration, users can track and analyze blood, fitness and sleep data all in one place, giving a clearer picture of how physiological and biomarker data is interconnected, unlocking new ways to improve health.

More Precise, Personalized RecommendationsThe more data InsideTracker has to work with, the more personalized a user's recommendations become. Each time Apple Watch registers a new, completed activity, InsideTracker progress updates in real-time, fine-tuning the personalized Action Plan.

New, Real-Time ProTipsProTips provide daily, laser-focused nuggets of wisdom that are personalized based on a user's information, backed by science and curated by InsideTracker's registered dietitians. Using data synced from Apple Watch, the integration unlocks hundreds of new ProTips on actions you can take to improve your exercise, RHR and sleep duration.

"InsideTracker is the only system that integrates this level of activity tracking with blood, DNA and lifestyle data, and we're excited to unlock these precision wellness and longevity benefits for 100 million Apple Watch users," said Dr. Gil Blander, co-founder and chief scientific officer, InsideTracker.

To unlock the integration, InsideTracker users with an Apple Watch can download the updated InsideTracker app with Apple Watch integration from the App Store starting today, then log into their InsideTracker account to connect their device.

Apple Watch users without an existing InsideTracker account can visit InsideTracker.com and select the plan that's right for them, provide a blood sample at a local Quest lab, via home kit or upload results from a recent physician-ordered test, then download the app to receive their blood test results, sync with their device and create a science-backed Action Plan to help them reach their personal health and wellness goals.

About InsideTrackerFounded in 2009 by top scientists from acclaimed universities in the fields of aging, genetics and biology, InsideTracker is a truly personalized nutrition and performance system. InsideTracker's mission is to help people add years to their lives and life to their years by optimizing their bodies from the inside out. By analyzing the body's data from blood, DNA and fitness trackers, InsideTracker gives a crystal-clear picture of what's going on inside, along with a science-backed action plan for improving your health and becoming your best self. Read our peer-reviewed papers inScientific Reportsand Current Developments in Nutrition.

Follow InsideTracker on Instagram, Twitterand Facebook.

Media Contact:Heather Hawkins[emailprotected](415) 598-8662

SOURCE InsideTracker

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10 Foods That Are Awesome When It Comes To Breast Health – The List

Saturday, April 2nd, 2022

Do you enjoy snacking on dried apricots or dried cranberries? Since dried fruit is basically fruit that is void of water, this means that you can get the same nutritional benefits of "regular fruit" minus the hydration. According to Healthline, dried fruit is really good for you because it contains all kinds of fiber, antioxidants, and micronutrients. That means it might lower your blood pressure levels, balance out your blood sugar, and keep you regular, and, because dried fruit is naturally sweet, it can also help to curb your appetite for processed sugar.

Dried fruits can be good for your breasts because they arehigh in phytoestrogen (plant-based compounds that mimic estrogen), as noted by an article published inPhytotherapy Research. As you age and your body loses estrogen, consuming phytoestrogen foods can potentially boost your estrogen levels so that you look more youthful and radiant breasts included. Dried fruit is one of the sweetest ways to keep your breasts looking younger for longer. Science can totally back this up!

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The secret to making your brain work better – Financial Times

Saturday, April 2nd, 2022

I take lions mane with a daily microdose of psychedelic, and B6 to switch on the brain and getmore ideas, says writer Catherine Frenette, ofthe effects of her supplements regime. I did it allthrough writing my latest book: I had a short deadline and needed to stay at my desk. It absolutely worked. Without doubt, Im working better.

Tired, unfocused brain in need of a boost? The traditional recourse coffee is, it turns out, very pre-pandemic. A stimulant made for 2019s office-worker world, when we were all just striving to keep up, its ashort-term fix that burns through your adrenal reserves and leaves you, ultimately, depleted. Nowadays, thats not good enough. Enter the latest nootropics cognitive enhancers that will take users up and up, and could support brain function and health in the long term.

Unlike coffee, these new nootropics, or smart drugs, nourish the brain without cashing in on its energy reserves. The brain is the bodys most hungry organ, consuming 20per cent of our energy, so it is vital that it is well fed. Stimulants such as coffee, Adderall or study drug Modafinil operate by robbing Peter to pay Paul: increasing dopamine while simultaneously depleting reserves.

We thinkitsnormal to be tired andforget things. Thats not normal. Weshould be feeling better

There is much debate about which nootropics to take, how to take them and how much to take. In online forums, the nootropic hive mind bandies about options that include amino acids like L-theanine and glutamine, thesalt magnesium threonate, nutrients citicoline and phosphatidylserine, adaptogenic herbs such as rhodiola and Bacopa, or the ubiquitously trending cordyceps.

Everybody wants to know about brain biohacking rightnow, reports Dr Tamsin Lewis, founder of Wellgevity,a personalised preventative healthcare service.Everything starts with the brain. If you can changeyour neurochemistry you movedifferently, you interact differently, the whole filterto your day changes. Lewis, whobegan trying nootropics following a head injury,believes plenty of improvement can be gained, butcounsels: Theresno one-size-fits-all everyones baseline functionis different.Shealso cautions that some supplements are notdosedcorrectly or do not include their ingredients in a bioavailable form its important to look for clarity when it comes to dosages.

Lewis recommends to her patients personalised blends of intravenous ingredients, including B vitamin complex and alpha lipoic acid. She says the latter is agreat enhancer of mitochondrial function, naturally increasing levels of glutathione [an amino acid involvedin cell repair]. It can make your brain feel veryclear for a good few weeks.

Another compelling ingredient is Cognizin, a version ofcholine, which is a compound derived from food, particularly eggs. It promotes the production of phospholipids, which make up the membranes of our neural cells. Studies of Cognizin demonstrate up to a 25percent increase in attention, memory and focus in patients versus a placebo. It is an ingredient available in brain-boosting supplements from Qualia to Mind Lab Pro. JulianLee, CEO of green tech business Binding Solutions, began taking Cognizin as one of the ingredients in the super-supplement Lyma. I have remarkably better energy and focus during theday, he reports. Things have really shifted. Im50 andin very good health and spirits I feel much younger than my age.Mentally, clear as a whistle.

If you can changeyour neurochemistry you movedifferently, you interact differently, the whole filterto your day changes

Over at Matt Roberts Evolution in Mayfair, where longevity doctors, physiotherapists and microdosing and psychedelic experts operate in tandem, a 60-something client is emerging from an intravenous glutathione infusionto treat her brain fog. Glutathione cleans out her cells, explains clinician nurse Michelle Gundry. We thinkitsnormal to be tired andforget things. Thats not normal. Weshould be feeling better. MattRoberts Evolution also hascoffee on the menu, butwitha difference: Mushroom coffee, confirms Roberts, madewith cordyceps to give youthe kick you need withoutthecomedown.

Medicinal mushrooms such as lions mane show someevidence of supporting neural health and cognition. Roberts recommends magnesium threonate for sleep (goodsleep is essential for brain recovery and memory)and the supplement NAD, which is essentially niacin (a vitamin B3 extract), or its more hardcore sister, NMN. NADmay increase human-growth hormone response andtherefore the ability of the bodys cells to regenerate. Watch how you take NMN, though, he says, as it needs to be attached to a fat molecule to be absorbable. Like almost everyone else I spoke to, Roberts cites gut health inthe form of a diet rich in plants and fermented foods asa key element in the quest to improve brain function andadaptability.

Neuroplasticity is also on the mind of Clinique La Prairie, the Swiss health and beauty brand, which declares ita fundamental aspect of healthy ageing. Cognition, says Professor Bogdan Draganski, a neuroscientist at the University Hospital of Lausanne and a member of CLPs scientific committee, is a key target for biohackers or neurohackers, as he calls them. Last year, Clinique La Prairie came out with its own health supplement range, Holistic Health. It has been formulated with the patented nootropic Cognivia, which showed a nine per cent increase in numeric working memory.

Much of the interest in neurohacking is fuelled by the work of key professors at Stanford, Harvard and Yale. Neuroscience professor Andrew Huberman at Stanford School of Medicine is one such guru, as is Harvard professor of genetics David Sinclair. Both publish their work daily on social media and have amassed huge followings. Sinclair believes its possible not onlyfor us tohalt cellular decline but to reverse it. Huberman recommends easy hacks such as 30minutes of sunlight every morning to set the circadian rhythm and put you in control of your nervous system.

Huberman also likes to publish his stack, which is how wellness nerds referto their supplement regime. On a recent podcast he listedhis latest, which included eating foods that are rich inomega-3s and/or supplementing with omega-3s to get 2-3gof the fatty acid EPA per day; phosphatidylserine, alipid-like compound abundant in meat and fish; choline, which helps in modulating brain circuits; and creatine asupplement the fitness-obsessed use to bulk up, but which is good fuel for the brain at least 5g a day, he said.

The science is changing all the time, says James Heagney, gym director of KX health club in South Kensington, where Chelseas most ambitious wellness disciples go forworkouts. We follow the research to choose not justthe nutrients gaining in popularity but those that havescientific backing.

Heagney is currently looking at dopaminergic supplements for focus and concentration, the amino acid tyrosine to improve alertness, and adaptogens like gingko and holy basil. As a 4am riser, and with two young children to wrangle, Heagney is laser-focused on his own stack. Increased performance and cognition is where its at, he says. Brain function is everything in the body.

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Irish study finds eight novel ways to live longer (it’s not all diet and genes) – The Irish Times

Monday, January 17th, 2022

Even if we have health problems, attitude dominates. Employing these strategies will help you to feel younger than your number

No two 83-year olds are the same. One can run a marathon whereas another may be frail and immobile. Why do some of us appear resilient to ageing while others seem older than our years?

What can we do for ourselves and as a society to ensure that we have fulfilling, happy and fit, long lives? Our research study, The Irish Longitudinal Study on Ageing (TILDA), which followed almost 9,000 adults aged 50 and older, has generated more than400 research papers over the past 12 years. The study covers all aspects of life from sex to food, to physical and brain health, genetics, childhood experience, expectations, friendships, finance and much more to illustrate why and how we age.

Differences in the pace of ageing occur because our biological changes count more than the crowd of candles on our birthday cake. One study showed a difference of 20 years in biological ageing clocks in adults as young as 38. Explanations include changes in metabolic and other cell proteins, often associated with higher inflammation in cells. We have trillions of cells that are dividing and producing new cells all of the time, but imbalances in these processes speed up cell damage and cell death and thus overall ageing.

The good news is that we control 80 per cent of our ageing biology only 20 per cent is controlled by our genes. So it is within our power to modify and improve most of the factors that influence our biological clocks, including inflammation.

Most of us are eager to know more about ageing and health. Yet at the same time many people in midlife tell me they can hardly bear to think about growing old, such is their dread of it.

But, the last lap as one of my patients cheerily calls it can be the most relaxed, worthwhile and contented period of our lives, especially if we prepare for it. The research confirms this. And the earlier we start, the better - although these recommendations are beneficial at any age.

As we know, diet, exercise, stopping smoking and low alcohol intake slow down ageing, but there are also unexpected and fun ways to make us more resilient to the ageing process. Here are eight simple things you can start tomorrow which will make a difference.

Good friends add years to our lives. Examining the association between social bonds and health, I was staggered by the powerful physical effects of friendship.

But why would the strength of our social contacts and social engagement affect mortality? Its been suggested that they lower levels of stress and stress-related hormones, heart disease and inflammation. In fact, regular contact with friends is as good for your heart as stopping smoking or normalising your cholesterol levels.

People who enjoy strong social bonds into their 80s were less likely to succumb to cognitive decline and dementia. The fact that social, mental and physical stimulation through friendships reduce vascular diseases is relevant here too.

High blood pressure, high cholesterol and heart irregularities, such as atrial fibrillation in midlife, are all associated with Alzheimers in later life.

The stress-busting effects of good friendships is another reason these relationships benefit brain health. A higher susceptibility to stress doubles the risk of dementia by triggering chronically high cortisol levels. Frequent social contacts increases the formation of new brain cells, building up capacity or cognitive reserve in the area that converts short-term memory to long-term memory, the area important for concentration, understanding, awareness, thought, languageand consciousness, and the area governing our sense of smell.

So even if people have abnormal proteins in their brain cells (dementia pathology), they dont show signs of the disease: their reserve capacity built through social contacts enables normal function. We laugh more when were with friends laughter bonds us with others.

Healthy children laugh as much as 400 times per day but older adults tend to laugh only 15 times per day. Yet laughter keeps us young.

As well as boosting endorphin levels, laughter is a form of muscular exercise, good for circulation and digestion. A good belly laugh provides a workout for the diaphragm, abs, and shoulders plus the immune system and heart.

Laughter is beneficial at a chemical level because it lowers the stress hormones cortisol and adrenaline. And low cortisol stabilises blood sugars and insulin, regulates blood pressure, and reduces inflammation.

Even when we only anticipate having a laugh, our positive hormonal system kicks in and risesas much as 87 per cent. The same expectation mutes stress hormones by up to 70 per cent. So, next time you search for your favourite Father Ted episode, know that you are building up your health stores and resources. (What would Dougal have to say about that, Ted?)

Laughter also increases endorphins chemicals produced naturally by the nervous system to cope with pain or stress, the feel-good chemicals. It raises serotonin and dopamine, which play a critical role in sensations of pleasure, motivation, memory and reward. They make us feel calm, poised, confident and relaxed.

When serotonin and dopamine levels are low, we are nervous, irritable and stressed. Endorphins also play a role in the immune response and in killer T cells, which help to fight infections. Given that immune function declines with age, boosting endorphins is particularly beneficial in older persons.

Stress is ageing. Its biological impacts affect our nervous system, hormones, immune system and metabolic systems. Persistent stress can lead to obesity, diabetes, high blood pressure, a fast heart rate, heart attacks and strokes. A visible measure of how acute stress can age us is that it can turn hair grey overnight. Simple techniques can provide a buffer against stress:

One is regular switch-off periods a time each day when phone and internet are turned off. Let friends and colleagues know you are doing this so that you are not stressed when the phone is off.

Share your worries with a friend. Research shows that a problem shared is a problem halved and, indeed, reduces stress by lowering cortisol.

Take up gardening. A recent paper analysed 22 studies on gardening and health. The host of positive effects included reductions in depression, anxiety, and BMI, plus a rise in life satisfaction and quality of life.

Walks in nature, forests and green spaces have a notably calming effect: stress levels fall and creativity increases dramatically.

Spend one minute doing controlled breathing a few times a day.

Do meditation for five minutes each morning. Brain scans show that meditation preserves the brains main structural tissues. It also potentially suppresses processes that contribute to brain ageing.

Dispositional mindfulness focusing attention to present thoughts and feelings has physical, psychologicaland cognitive benefits (its the opposite of letting our mind wander and fretting about the future).

Falls are the main cause of accidental deaths and of fractures as we get older. Almost half of people who break a hip never regain their previous independence or vitality. Balance starts to decline after age 40 and is one of the commonest reasons for falls.

So work on balance. Agood start is to stand on one leg while brushing your teeth or at the kitchen sink. Can you stand on one leg for 30 seconds eyes open and 10 seconds eyes closed? That should be your target. Pilates also improves balance and core strength.

Cold water immersion provides a stimulus to our physiological systems, which is related to the phenomenon of hormesis, whereby small amounts of a harmful or painful agent are actually good for us and for the ageing process.

Exposure of the skin to cold water increases release of important nerve signals and chemicals. Chemicals such as noradrenaline, endorphins and opioids are increased and boost performance of cells in both the brain and body that regulate a host of functions such as heart rate, blood pressure, blood flow to muscles, power of contraction of skeletal muscles and release of energy.

Neurotransmission in brain areas that control emotions including depression, concentration, memory and alertness are improved. Because responsiveness to noradrenaline declines with age, any stimulus that enhances its activity is important to ageing physiology.

Hormesis also boosts immune responses and reduces frequency of chest infections. Start at 20 seconds after completing ablutions in warm water and gradually work up to two minutes. Youll eventually find it is addictive. Try it and see.

Until recently, humans were predominantly exposed to, and their lives and evolution depended on, yellow light (wavelength 570-590nm). Blue light (wavelength 450-495nm) exposure was limited to a few hours in winter.

However, over the past few decades blue light has been used more and more, emitting from devices such as televisions, phones and computers. Blue light suppresses melatonin, which is our bodies natural sleeping tablet, thereby causing sleep disorders and insomnia.

Melatonin declines with ageing. So to help with sleep, which plays a major role in the ageing process, and during which our memory stores are refreshed, avoid blue light for at least one hour before bed. Taking a hot bath will also help to enhance sleep and fill the time that you would normally use looking at a device.

As well as improving balance and flexibility at a cellular level, yoga reduces inflammation and thereby slows biological ageing. Several studies show that yoga increases the length of telomeres the protective coverings at the end of chromosomes which stop chromosomal damage. With ageing, telomeres shorten, chromosomes are damaged, cells decay and die.

Fascinating animal studies show that if two groups of animals are fed the same amount of food within 24 hours, but one group just gets all the food within eight hours and the other over 24 hours, the latter become obese and the former do not.

Much research supports the fact that metabolic proteins and hormones are some of the most important in respect of cell ageing and that restricting foods and periods of fasting switch on protective cell mechanisms beneficial for longevity. Grazing throughout the day is bad news. So try to stick to eating within an eight-hour window and no snacks.

The science shows that you are as young as you feel be optimistic about your biological age it will affect how you age. Our studies show that people who feel their chronological age are more likely to develop physical frailty and poor brain health in subsequent years than those who claim to feel younger than they are.

Older adults with negative perceptions about ageing are likely to die seven and a halfyears earlier, mostly because of higher rates of heart disease. A positive attitude towards getting older changes cell chemicals beneficially, possibly by reducing inflammation (low-grade chronic inflammation, from impaired immune responses, is associated with accelerated ageing and many age-related conditions).

Even if we have health problems, attitude dominates. Employing the strategies above will help you to feel younger than your number.

Age Proof: The New Science of Living a Longer and Healthier Life by Prof Rose Anne Kenny is published by Lagom. ProfKenny holds the chair of medical gerontology at Trinity College Dublin and is the founder and principal investigator of The Irish Longitudinal Study on Ageing (TILDA), Irelands flagship research project in ageing

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Independent Seed Companies Aspire for Longevity and Differentiation – Seed World

Monday, January 17th, 2022

Mergers and acquisitions rock the boat in every sector its no different in agriculture. The question comes into play: how are independent seed companies responding?

While weve seen consolidation recently, its not necessarily a sharp increase, says Todd Martin, CEO of the Independent Professional Seed Association (IPSA). Its for a whole host of reasons: business is tougher, companies have to be able to mark growth and were seeing retirements and succession planning play into this.

Independent seed companies play an important role in providing choices to farmers in the U.S. and beyond. Understanding the challenges they face and the current environment will give you a better idea as to the health of this sector of the U.S. seed industry.

M&As in the News

In 2021, Seed World reported several mergers or acquisitions within the seed sector. One independent in the news includes Rob-See-Co, making headlines twice, once for acquiring NorthStar Genetics in March and again in August for its acquisition of Masters Choice.

In each of these acquisitions, Rob Robinson, CEO of Rob-See-Co, states his excitement for bringing in other family-owned businesses. The footprints of the companies will remain largely the same, with small changes outlined by Robinson in their announcement of the acquisitions.

Acquisitions like this can excite some in the independent sector because it provides businesses the opportunity to continue when owners decide not to stay involved in the operation for one reason or another. The business lives on just under a different name.

Legacy Agripartners, a recently-renamed holding company, aims to bring together seed companies in the Midwest. Their goal isnt to change their operations or names, but instead to give them more power under a unified leadership team. Right now, Legacy Agripartners community of seed companies includes Legacy Seeds and DF Seeds.

If we were just seeing these companies being eliminated from local communities in rural America, this would be a step backward for our industry and for farmers, says Colin Steen CEO, Legacy Agripartners. So, I see some of the way its being done as positive. It can give life to a brand beyond the life of the current owners.

Despite numerous announcements over the past decade, experts say merger and acquisition activity isnt any more active than theyd expect. When compared to the heyday of the late 1990s and early 2000s, its down significantly, and not likely to spike to an incredible degree.

For corn and soybean companies, activity has been down for the past eight years comparatively, says Garrett Stoerger, partner at Verdant Partners, a transaction advisory firm based in Illinois. These latitudinal moves in the market are actually pretty healthy because for a lot of these companies its a form of succession planning and a way to stay in the business.

That said, hes keeping an eye on the vegetable seed industry. Theres high demand but incredibly low supply of vegetable breeding companies its a sellers market in that sector.

Differentiation is Paramount

Independent seed companies are faced with many of the same challenges seen across the industry: access to talent and the need for differentiation. For independents, however, the challenges are exasperated by having fewer resources than multi-national competitors.

One of our biggest challenges is how do we differentiate from other independent seed companies? Steen says. We all rely on the same or similar sources for germ plasm and traits, so not only do we need to differentiate from those providers but also from each other.

He suggests taking the time to figure out what each company can highlight as a key strength, including:

Bookend these differentiators by selecting high quality genetic and trait packages that suit the needs of the farmer in that area. Steen notes that once companies discover what their key differentiating factor is, take that messaging from the CEOs desk to the field to ensure unified conversations.

I think [another] key piece we have to recognize is that independents are under an enormous amount of pressure from their access to genetics, Martin explains. A key difference between the U.S. and say, Canada, is the approach to selling. In the U.S., independent seed companies can license and sell the same genetic package, they cant in Canada. Thats tough and it minimizes competition.

Genetic licensing is a key part of independent seed company businesses, and continued access to variety is needed. Corn and soybean genetics are widely licensed in the U.S., and while it might be the same DNA, Martin says companies can differentiate their offer with other services.

They might be the same genetics, but the value proposition is altogether different, different quality, different seed treatments and different sales approaches, he explains.

A Shrinking Labor Pool

Undoubtedly, one of the growing challenges for anyone in business is labor shortages. From internal staffing shortages to shortages in the supply chain, labor challenges are affecting how everyone does business.

The challenge for independents is proving that smaller and local companies can provide opportunities for employees they cant find elsewhere.

Labor is a big struggle of ours, no different than anyone else, Steen says. There are fewer of us in the company and that means we provide a wider variety of work experience. And theres a connection to leadership throughout because we want to hear all ideas.

While the competition for labor is fierce, the seed industry continues to find innovative ways to lure talent. From flexible schedules to work-from-home and hybrid environments, to expanded benefits, the seed industry continues to find innovative ways to attract talent.

Strong Future

While challenges are ever-present for independent seed companies, theyre committed to the industry.

We do have a lot of challenges: differentiation, aging ownership, etc. Steen says. But to sum it all up, its worth the fight to stay in it. We provide a really important service for farmers and local communities.

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The benefits of intermittent fasting the right way – BBC News

Monday, January 17th, 2022

Someone who has a high-carb diet might never move beyond the catabolic state as they will always have a reserve supply of glycogen. However, someone with a low-carb diet and who regularly exercises might move through it very quickly (the keto diet, in which you cut out almost all carbs to maintain low blood glucose levels and glycogen stores, works in the same way). I would move away from intermittent fasting for fat loss, and if you want to adopt it think about the health benefits, says Clarkson.

How to fast

To fast you have to downregulate the feeling of hunger, says Clarkson. Hunger is felt when ghrelin, a hormone released from our stomach, triggers the production of two other hormones, called NPY and AgRP, in the hypothalamus.

While these three hormones generate feelings of hunger, there are a multitude more that suppress it. Sometimes called the satiety hormones, one of the key ones is leptin which is released from fat cells to suppress the production of ghrelin basically telling the body "there is fat here that you can burn".

Ghrelin is sometimes called the short-term hunger response because it is released when the stomach is empty and there is less pressure on the stomach wall. It can be overridden to a certain extent by drinking water. Leptin meanwhile works over the long term.

Our hunger hormones are regulated by many things, genetics being one of them, says Clarkson. But thinking about the nerves that are attached to our stomach and digestive tract if your stomach is not distended your body will think it is hungry. She adds that staying hydrated can help with the early feelings of hunger until your body has adjusted. The first couple of weeks will be tough, but you get used to it.

For most people, ketosis occurs 12-24 hours after eating, so if you have your evening meal between 18:00 and 20:30, the fed state would end between 21:00 and 23:30 and ketosis and autophagy might occur by 06:00 to 08:30 the following morning. But the majority of people are sitting down and opening a packet of something else after dinner, says Clarkson. Snacking or sugary drinks and beer extend the fed state for three hours. If you finish snacking at 21:30-22:00, the fed state is being taken to 01:00-03:00, she says. This might mean ketosis never occurs before you next have a meal.

If you can make the informed decision of eating the evening meal an hour earlier and not snacking, you may be getting into that ketosis state by morning, versus someone who is having the high-carb evening meal and snacking, waking up at 06:00 and never getting into that state, she says. Clarkson suggests starting by eating earlier on a Sunday evening, or having breakfast an hour later and starting from there, building up from one or two days each week.

With a careful approach, intermittent fasting might help your body to perform its own repairs and recoveries. Autophagy appears to decline with age, so giving yourself a boost later in life might be useful. But be aware that it might not be the right strategy for weight loss, and there is no replacement for a balanced diet.

William Park is a senior journalist at BBC Future and is@williamhparkon Twitter.

All content within this article is provided for general information only, and should not be treated as a substitute for the medical advice of healthcare professionals. You should speak to your doctor or healthcare professional if you are pregnant or have a health condition such as diabetes and are considering intermittent fasting, are planning to fast long-term, and you should not avoid fluids while fasting.

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Lifeist Subsidiary Mikra Cellular Sciences to Launch First Product CELLF to Combat Brain Fog and Unlock Healthy Aging, Announces U.S. Patent…

Wednesday, December 8th, 2021

- Mikra patent focusing on novel cellular therapeutic targeting systemic fatigue- Mikra partners with InVivo Biosystems for pre-clinical trials to strengthen patent application and generate further data confirming expression pathways for genes

TORONTO, Dec. 06, 2021 (GLOBE NEWSWIRE) -- Lifeist Wellness Inc. (Lifeist or the Company) (TSXV: LFST) (FRANKFURT: M5B) (OTCMKTS: NXTTF), a health-tech company that leverages advancements in science and technology to enable you to find your path to wellness, today announced that its newly launched biosciences and consumer wellness subsidiary, Mikra Cellular Sciences Inc. (Mikra), is poised to launch its first product CELLF, a novel cellular therapeutic compound targeting systemic fatigue. As part of pre-launch activities of CELLF, Mikra has filed a patent application with the United States Patent and Trademark Office and partnered with InVivo Biosystems, Inc. (InVivo Biosystems) for pre-clinical trials to strengthen its patent claim.

The real health crisis isnt reduced longevity were living longer than we have in the past. Its extended morbidity thats the problem. While were all familiar with mortality, morbidity is attributable to age-related diseases that lower your quality of life which is why so many of us when we hit our 30s, 40s and 50s experience multiple physiological and mental walls notably brain fog, fatigue, and inflammation. This all happens at a cellular level, and it can cascade into poor sleep, mood drops, and an inability to enjoy life like you want to, said Faraaz Jamal, COO of Lifeist and CEO of Mikra. With that in mind, Im extremely excited to present Mikras first product, CELLF (pronounced self). We engineered this product for everyone who has started to feel like their biological age is affecting their everyday performance and ability to feel like the best version of themselves.

Continued Jamal, CELLF works at a cellular level to help combat systemic fatigue, inflammation, and brain fog by promoting the creation of mitochondria and subsequently increasing their efficiency. This is in addition to the upregulation and downregulation of certain cellular detoxification pathways that can remove the buildup of senescent (old/dysfunctional) cells that may cause excessive chronic inflammation and uncontrolled cell division.

CELLF - A science-backed cellular therapeutic, treating systemic fatigue and low-grade cellular inflammation

CELLF is manufactured in a proprietary oxygen-deprived environment to maintain biopotency and bioavailability with clinically tested United States Food & Drug Administration (FDA) certified GRAS (generally recognized as safe) bioactive ingredients. The CELLF compound delivery system is a two-stage, patented mechanism it is first bound to a transferrin glycoprotein and then encapsulated within a liposome. This allows safe passage of CELLF through the gastric environment and delivery directly into the blood plasma. The result is optimal delivery of our compound with minimal degradation to the best site of absorption. CELLF will be shipped in a package containing 30 X 10ml single-serve sachets to prevent oxidation and maximize bioavailability.

Youve got to satisfy two conditions for a product like this to work. The first is that the molecules within the compound need to be backed by rigorous science. The second is that you need to deliver it effectively into your body, and more specifically, your cells so that it is maximally absorbed. Very few products satisfy the first, let alone the second, said Jamal. As one of my lifelong heroes, Carl Sagan once said, extraordinary claims require extraordinary evidence, which is why weve partnered with Invivo Biosystems to prove and strengthen our patent claim that CELLF does both.

Mikra Partners with InVivo Biosystems

Mikra has partnered with InVivo Biosystems, experts in genetic model creation and in vivo testing, to strengthen its patent application by conducting a pre-clinical study identifying genetic signatures and pathways associated with average human healthspans and to test the effects of CELLF on healthy aging.

We are proud to partner with Mikra in developing a family of healthy living products that reduce biological aging. At InVivo Biosystems, we take a systematic, multi-omics approach to make gene-by-gene discoveries and uncover the different genetic pathways that are up or down regulated during aging. The InVivo Longevity Platform measures the complex interplay of cellular proliferation, autophagy, mitochondrial oxidative stress, genetic predisposition, and transcriptional changes that occur during aging, said Chris Hopkins, PhD, Chief Science Officer at InVivo Biosystems. In our collaboration with Mikra, we are exploring how its flagship formulation, CELLF, increases the efficiency of mitochondrial ATP production and cellular respiration. Using the InVivo Longevity Platform, we measure at the molecular level how Mikras CELLF formulation can counter periodic bouts of fatigue by providing improved cellular respiration. In our partnership, we will be generating the science-based evidence that Mikra can use as further backbone for their intellectual property claims. Here at InVivo Biosystems we are also excited to continue partnering with Mikra in the future to uncover further how CELLF, and their future product lines, can create a new baseline for healthy living after 30.

CELLF Product & Community Launch

Im very excited about adding incremental value to Lifeist shareholders and unlocking the earnings potential of Mikra and subsequently Lifeist. Were taking the first steps here with bringing something novel to the market, validating and protecting it. But lets be clear, its only the first step, said Meni Morim, CEO of Lifeist. The initial traction Mikra has had around the pre-launch has been very promising to grow to a community of nearly 20,000 with a huge level of engagement, in such a short amount of time and with no sign of stopping is a testament to the teams expertise and validates the consumers desire for this type of product.

Mikras CELLF will be available for pre-sale in mid-Q1 2022 with a waitlist sign up available at http://www.wearemikra.com. CELLF will be available on http://www.wearemikra.com and Amazon following the pre-sale for full public launch.

Follow Mikras journey on your favorite social media platform with @wearemikra.

About Mikra, Cellular Sciences Inc.Mikra is a biological sciences and consumer wellness company on a mission to increase your healthspan by focusing on the tiniest aspect of your health: the cell. People are made up of over 37 trillion cells with a variety of different sizes, shapes, functions and lifespan. These cells are responsible for energy, happiness, recovery potential and so much more. Mikra is exploring the link between changes at a cellular level and the cascading effects it can have on health.

About InVivo Biosystems, Inc.InVivo Biosystems, an expert in genetics, delivers scientific proof and evidence for ingredients at the molecular and cellular level via a proprietary analytical approach. Its analytical platform helps branded ingredient developers and manufacturers substantiate their product claims, file IP patents, or refine their formulations using the best science backed measure of outcome. Managed by experienced PhD scientists, InVivo Biosystems gene expression platform can help find new applications for novel ingredients, discover new molecules, and conduct proof-of-concept studies for therapeutic purposes. Visit http://www.invivobiosystems.com/longevity for more information.

About Lifeist Wellness Inc.Sitting at the forefront of the post-pandemic wellness revolution, Lifeist is a portfolio of wellness companies leveraging advancements in science and technology to enable individuals to find their personalized path to wellness. Portfolio business units include: CannMart, which operates a B2B wholesale distribution business facilitating recreational sales to Canadian provincial government control boards and the CannMart.com marketplace which provides Canadian medical customers with a diverse selection of cannabis products from a multitude of federally licensed cultivators and its U.S. customers with access to hemp-derived CBD and smoking accessories; Australian Vapes, the countrys largest online retailer of vaporizers and accessories; Findify, a leading AI-powered search and discovery platform; and Mikra, a biosciences and consumer wellness company seeking to develop innovative therapies for cellular health and recovery.

Information on Lifeist and its businesses can be accessed through the links below:www.lifeist.com http://www.cannmart.com http://www.everyonedoesit.co.uk http://www.australianvaporizers.com.au http://www.wearemikra.com

Contacts

Lifeist Wellness Inc.Meni Morim, CEOMatt Chesler, CFA, Investor RelationsPh: 647-362-0390Email: ir@lifeist.com

Forward Looking Information

This news release contains forward-looking information within the meaning of applicable securities laws. All statements contained herein that are not historical in nature contain forward-looking information. Forward-looking information can be identified by words or phrases such as may, expect, likely, should, would, plan, anticipate, intend, potential, proposed, estimate, believe or the negative of these terms, or other similar words, expressions and grammatical variations thereof, or statements that certain events or conditions may or will happen.

The forward-looking information contained herein, including, without limitation, statements related to the launch of Mikras first product CELLF and its anticipated therapeutic benefits, are made as of the date of this press release and is based on assumptions management believed to be reasonable at the time such statements were made, including, without limitation, expectations that pre-clinical trials will prove successful and that the Companys application for a patent will be granted, expectations that CELLF will gain market acceptance along with the expansion of the market for nutraceutical products and managements perceptions of Lifeists standing in the online marketplace for wellness and related products, Lifeists beliefs regarding the expected demand for wellness and related products and the expected growth of that market, the timing of product availability, as well as other considerations that are believed to be appropriate in the circumstances. While we consider these assumptions to be reasonable based on information currently available to management, there is no assurance that such expectations will prove to be correct. By its nature, forward-looking information is subject to inherent risks and uncertainties that may be general or specific and which give rise to the possibility that expectations, forecasts, predictions, projections or conclusions will not prove to be accurate, that assumptions may not be correct and that objectives, strategic goals and priorities will not be achieved. A variety of factors, including known and unknown risks, many of which are beyond our control, could cause actual results to differ materially from the forward-looking information in this press release. Such factors include, without limitation: unforeseen developments that would delay the Companys ability to launch CELLF as anticipated and in a timely manner, the risk that pre-clinical trials are not as successful as anticipated and do not demonstrate anticipated therapeutic benefits and/or fail to strengthen the Companys patent claim, the risk that the expected demand for nutraceutical products in general and those of the Company does not develop as anticipated, regulatory risk, risks relating to the Companys ability to execute its business strategy and the benefits realizable therefrom and risks specifically related to the Companys operations. Additional risk factors can also be found in the Companys current MD&A and annual information form, both of which have been filed under the Companys SEDAR profile at http://www.sedar.com. Readers are cautioned not to put undue reliance on forward-looking information. The Company undertakes no obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, except as required by applicable law. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release or has in any way approved or disapproved of the contents of this press release.

Source: Lifeist Wellness Inc.

Photos accompanying this announcement are available at:

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Lifeist Subsidiary Mikra Cellular Sciences to Launch First Product CELLF to Combat Brain Fog and Unlock Healthy Aging, Announces U.S. Patent...

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Longevity and anti-aging research: Prime time for an …

Sunday, November 21st, 2021

Research into longevity and healthy aging has progressed rapidly in recent years, but intense interest from the public, corporations, and the media has created an environment in which unfounded claims can be hard to separate from scientific facts.

In February, a group of 16 researchers from Harvard, MIT, and other institutions around the U.S. and Europe launched the nonprofit Academy for Health and Lifespan Research to promote future work, ease collaborations between scientists, and ensure that governments and corporations are making decisions based on the latest facts instead of rumor, speculation, or hype.

The Boston-based organization will form a nexus for work on extending the human health span, fighting the myriad diseases associated with aging, and fostering the work of junior researchers. Harvard Medical School Genetics Professor David Sinclair, one of the new academys founding members and director of the Paul F. Glenn Center for the Biology of Aging at HMS, spoke to the Gazette about the status of aging research and the mission of the academy.

GAZETTE:Tell me about the academy. Is it intended to be mainly an advocacy organization?

SINCLAIR: The academy has been formed because our field of aging and longevity research has reached a point of maturity where the leaders in the field believe that we can have or will have a big impact on the planet. That impact will be in medicine, in health span, and in its knock-on effect on [everything from] human productivity to Social Security.

We wanted to come together to speak with one voice, to be able to help corporations and governments understand what things they should be thinking about now and give realistic projections of what life is going to be like 10, 20, 50 years from now. Because its not a question of if theres going to be an impact, its really a question of what kind of a future we want to build when this happens.

GAZETTE: What kind of impact are we talking about? When you think about 10, 20, 50 years in the future, how do you see aging being transformed in the U.S. and around the world?

SINCLAIR: The 16 researchers in the academy have all been working on this for most, if not all, of our careers. So that spans for many of us over 25 years. When we started, research on aging at the molecular level was the backwater of biology, but in the last 25 years, aging has moved to the forefront of science. Its actually rare to open a leading scientific journal and not see a new breakthrough in our understanding of the aging process.

Recently, weve moved from being able to extend health and lifespan of simple organisms like yeast and worms and flies to being able to do this quite easily in animals, in mice and monkeys. With that knowledge how to keep the body younger and not develop diseases of aging we think its now prime time for having an impact on the globe.

By impact, I mean that instead of tackling one disease at a time, which is the way 20th-century medicine and pharmaceutical development was practiced, we believe we can [develop] medicines that will treat aging at its source and thereby have a much greater impact on health and lifespan than drugs that target a single disease.

Heart disease medicine may keep your heart healthy for an extra five or 10 years, but does nothing for your brain. So, were ending up with a population of people who live longer but not better and who need a lot of help, if theyre not completely [in the grip of] dementia. We dont think thats necessarily the only or the best approach.

Were generally in denial that, for most of the diseases that we get these days, the root cause is aging. I dont know 10-year-olds that get Alzheimers disease or heart disease.

David Sinclair

Now, we have the knowledge. Were developing the technologies to not just delay these diseases of aging but actually reverse aspects of them. Imagine you have a treatment for heart disease, but as a side effect youd also be protected against Alzheimers, cancer, and frailty. Youd live a longer and healthier life.

The reason we can extend the lifespan of animals is not because we can just make them live longer, but we keep them healthy. The animals dont get heart disease, cancer, Alzheimers, until sometimes 20 percent later in their life. And so thats 20 percent longer youth, not just 20 percent longer life.

GAZETTE: Are there regulatory hurdles? When weve spoken in the past, youve mentioned that the FDA considers aging a natural process and therefore wont approve drugs to treat it. Are we at a point where that is becoming a hurdle in getting advances out to the people who need them?

SINCLAIR: Opinions are changing rapidly about whether aging should be a condition that a doctor can prescribe a medicine for. Thats essentially what a disease is. Its something that a doctor can read the label that this medicine is for aging or age-related conditions. Were not at that point yet.

We currently live in a world where aging is so common that its considered by most of the world, including the medical community, as something thats natural and inevitable. And if somethings considered inevitable, typically you dont focus on it in the same way as something you can treat. Cancer was a natural part of life at one time, in the same way that aging is today. A hundred years ago, doctors didnt focus on treating cancer as much as we do now, because then you couldnt do much, if anything, about it. As soon as you show you can modify the disease process, like we learned in the 1970s with the discovery of oncogenes that cause cancer and increasingly so today then theres renewed hope, and views about the condition shift.

There are now dozens of companies working on therapies that could potentially extend overall human health and lifespan, but none of them are working specifically toward an approval for aging because the FDA wouldnt even know where to start. But that may be changing quickly. Ive been part of a group that talked with the FDA, and they are willing and also quite enthusiastic about considering a change that defines aging as a disease. They would like us, first, to show that its possible to change the rate of aging, which in my view is backward, but thats what they want.

In Australia, the government is 100 percent behind this, at the FDA level and in the Ministry for Health. Im hopeful that one country in the world it may be Australia, it may be the U.S., it may be an Asian country will change its definition of aging. Once one country changes its definition, then it will be a domino effect and the others will follow.

One of the biggest changes that happened last year was the World Health Organization, in their international disease codebook, declared aging a condition that is treatable. So now doctors and countries can report back to the World Health Organization how many people in their country are suffering from this condition known as old age.

Were generally in denial that, for most of the diseases that we get these days, the root cause is aging. I dont know 10-year-olds that get Alzheimers disease or heart disease. Its aging that increases the risk 1,000-fold for cancer, while if you smoke, it goes up fivefold. Which is more important to be focused on?

GAZETTE: What excites you most about the state of anti-aging and longevity research?

SINCLAIR: Well, I hate to pick favorite children. Someone will always be upset. I have my hands in a few pies, but the most recent one that Im excited about is cellular reprogramming.

GAZETTE:And how does that occur?

SINCLAIR: We introduce a combination of genes into the animal, or the cell, and we see that the tissue is rejuvenated as though it was young again. So it can heal, it can start new growth, like it was young. And if we can figure out how to deliver that to patients in a safe way, then its quite possible that aging is a reversible disease.

GAZETTE: What genes are we changing?

SINCLAIR: Were using a combination of Yamanaka factors [used to reprogram differentiated adult cells into induced pluripotent stem cells] that are used to make stem cells currently in a dish, but what were finding is that you can introduce them into the animal as well. They tolerate it well and tissues rejuvenate.

I havent published it yet, so I cant say too much, but were writing up the paper now that shows that parts of the mouses body that we thought would not ever improve are able to be regenerated. So were licensing that technology and hoping that it will be tested in the clinic in the next two years.

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North American South Devon Association

Sunday, November 21st, 2021

In the beef cattle industry today, South Devon cattle deliver necessary traits for success. They are an English breed that can outcross with other English and Continental cattle breeds.

Tests and years of selective breeding on five continents show that South Devon cattle are feed efficient, fertile and maternal, with superior carcass traits. They are well-known for their longevity and 100s of years of docility are bred right into their genetics.

These economically important traits combine a uniform approach and balance to commercial and registered ranching and feeding operations with the use of South Devon genetics.

Profit driven cow/calf operations are looking for a level of fertility, low feed intake, high weaning weight production and calf value that South Devon can deliver. In the feedlot, lower feed intake and carcass merit are a compliment of the South Devon breed.

In North America South Devon cattle are primarily polled and can be found in black or red-hided genetics.

Cattle operations using South Devon genetics can increase their profitability with a breed suitable for any North American geographic location.

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Can drinking red wine ever be good for us? – BBC Future

Sunday, November 21st, 2021

The researchers also found that people who drank red wine had a lower body mass index (BMI). This also could be why drinking red wine in moderation is associated with health. Its not that red wine makes you healthier; its that red wine drinkers may be healthier to begin with.

People who drink red wine often also do more exercise and [are] more affluent and healthier, says Bellis.

The same is true of the gut health question: because the study was observational, the researchers couldnt establish whether a single glass of red wine a week makes your gut healthier, or people with healthier guts happened to be the kind to drink a glass a week. And randomised control trials, where participants are split into groups and their health measured as they follow different diets, can be particularly unethical when it involves alcohol.

There have been a few randomised control trials but these have been less than conclusive. A 2016 study found that having one glass of red wine with their evening meal every day for six months didnt affect the blood pressure of people with diabetes.

Another randomised control study from 2015 found that drinking 150ml of red wine (again, the amount held in a champagne flute), can lower the risk of developing stroke and heart disease among people with diabetes.

Healthiest option

In fact, while red wine may be the healthiest drink option, its healthier to abstain entirely, says author of the study looking at wine consumption and gut health, Caroline Le Roy, research associate at the Department of Twins Research at Kings College London.

We know alcohol is bad for us, she says. If you drink, it should be red wine, as this is the only alcoholic drink thats been found to have a beneficial effect, but Im not encouraging people to drink red wine.

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Can drinking red wine ever be good for us? - BBC Future

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Gero scientists found a way to break the limi | EurekAlert!

Sunday, November 21st, 2021

image:Schematic illustration of loss of resilience along aging trajectories view more

Credit: GERO PTE. LTD.

The research team of Gero, a Singapore-based biotech company in collaboration with Roswell Park Comprehensive Cancer Center in Buffalo NY, announces a publication in Nature Communications, a journal of Nature portfolio, presenting the results of the study on associations between aging and the loss of the ability to recover from stresses.

Recently, we have witnessed the first promising examples of biological age reversal by experimental interventions. Indeed, many biological clock types properly predict more years of life for those who choose healthy lifestyles or quit unhealthy ones, such as smoking. What has been still unknown is how quickly biological age is changing over time for the same individual. And especially, how one would distinguish between the transient fluctuations and the genuine bioage change trend.

The emergence of big biomedical data involving multiple measurements from the same subjects brings about a whole range of novel opportunities and practical tools to understand and quantify the aging process in humans. A team of experts in biology and biophysics presented results of a detailed analysis of dynamic properties of the fluctuations of physiological indices along individual aging trajectories.

Healthy human subjects turned out to be very resilient, whereas the loss of resilience turned out to be related to chronic diseases and elevated all-cause mortality risks. The rate of recovery to the equilibrium baseline level after stresses was found to deteriorate with age. Accordingly, the time needed to recover was getting longer and longer. Being around 2 weeks for 40 y.o. healthy adults the recovery time stretched to 6 weeks for 80 y.o. on average in the population. This finding was confirmed in two different datasets based on two different kinds of biological measurements - blood test parameters on one hand and physical activity levels recorded by wearable devices on the other hand.

"Calculation of resilience based on physical activity data streams has been implemented in GeroSense iPhone app and made available for the research community via web-based API." - commented the first author of the study, Tim Pyrkov, head of the mHealth project at Gero.

If the trend holds at later ages, the extrapolation shows a complete loss of human body resilience, that is the ability to recover, at some age around 120-150 y.o. The reduced resilience was observed even in individuals not suffering from major chronic disease and led to the increase in the range of the fluctuations of physiological indices. As we age, more and more time is required to recover after a perturbation, and on average we spend less and less time close to the optimal physiological state.

The predicted loss of resilience even in the healthiest, most successfully aging individuals, might explain why we do not see an evidential increase of the maximum lifespan, while the average lifespan was steadily growing during the past decades. The divergent fluctuations of physiological indices may mean that no intervention that does not affect the decline in resilience may effectively increase the maximum lifespan and hence may only lead to an incremental increase in human longevity.

Aging in humans is a complex and multi-stage process. It would, therefore, be difficult to compress the aging process into a single number, such as biological age. Gero's work shows that longitudinal studies open a whole new window on the aging process and produce independent biomarkers of human aging, suitable for applications in geroscience and future clinical trials of anti-aging interventions.

"Aging in humans exhibits universal features common to complex systems operating on the brink of disintegration. This work is a demonstration of how concepts borrowed from physical sciences can be used in biology to probe different aspects of senescence and frailty to produce strong interventions against aging.", - says Peter Fedichev, co-founder and CEO of Gero.

Accordingly, no strong life extension is possible by preventing or curing diseases without interception of the aging process, the root cause of the underlying loss of resilience. We do not foresee any laws of nature prohibiting such an intervention. Therefore, the aging model presented in this work may guide the development of life-extending therapies with the strongest possible effects on healthspan.

"This work by the Gero team shows that longitudinal studies provide novel possibilities for understanding the aging process and systematic identification of biomarkers of human aging in large biomedical data. The research will help to understand the limits of longevity and future anti-aging interventions. What's even more important, the study may help to bridge the rising gap between the health- and life-span, which continues to widen in most developing countries." - says Brian Kennedy, Distinguished Professor of Biochemistry and Physiology at National University Singapore.

"This work, in my opinion, is a conceptual breakthrough because it determines and separates the roles of fundamental factors in human longevity - the aging, defined as progressive loss of resilience, and age-related diseases, as "executors of death" following the loss of resilience. It explains why even most effective prevention and treatment of age-related diseases could only improve the average but not the maximal lifespan unless true antiaging therapies have been developed" - says prof. Andrei Gudkov, PhD, Sr. Vice President and Chair of Department of Cell Stress Biology at Roswell Park Comprehensive Cancer Center, a co-author of this work and a co-founder of Genome Protection, Inc., a biotech company that is focused on the development of antiaging therapies/.

"The investigation shows that recovery rate is an important signature of aging that can guide the development of drugs to slow the process and extend healthspan." - commented David Sinclair, Harvard Medical School professor of genetics.

"The research from Gero surprisingly comes to a similar quantification of human resilience - a proposed biomarker of ageing - based on two very different kinds of data: blood test parameters on one hand and physical activity levels recorded by wearable devices on the other hand. I'm very excited to see how Person-generated Health Data, including data from commercial wearables, can help create individual, longitudinal profiles of health that will be instrumental to shed light on lifetime-scale health phenomena, such as ageing." - commented Luca Foschini, Co-founder & Chief Data Scientist at Evidation Health.

Two aging markers

The authors characterized the dynamics of physiological parameters on time scales of human lifespan by a minimum set of two parameters. The first is an instant value, often referred to as the biological age, and is exemplified in this work by the Dynamic Organism State Index (DOSI). The quantity is associated with stresses, lifestyles and chronic diseases and can be computed from a standard blood test.

The other parameter - the resilience - is new and reflects the dynamic properties of the organism state fluctuations: it informs how quickly the DOSI value gets back to the norm in response to stresses.

When does aging start?

Age-related changes in physiological parameters start from birth. However, various parameters change in different ways at different stages of life, see, e.g., a previous work by the same authors published in Aging US in 2018).

The data from the Nature Communications work shows that there is a good differentiation between the growth phase (mostly complete by the age of 30 and following the universal growth theory by Geoffrey West and aging. At 40+ years, aging manifests itself as a slow (linear, sub-exponential) deviation of physiological indices from their reference values.

How often should one measure biological age?

Physiological parameters are naturally subject to fluctuations around some equilibrium level. Glucose levels rise and drop after having a meal, the number of sleeping hours is slightly different each day. Yet, one can collect a longitudinal dataset, that is a series of such measurements for the same person, and observe that the average levels are different between individuals. Resilience also requires repeated measurements, since one needs to know exactly when recovery was achieved to calculate the resilience.

Importantly, resilience also provides a convenient guide on how often repeated measurements should be taken. As a rule of thumb, the period of observation required for the robust bioage determination should comprise multiple stress and recovery events. For the most healthy individuals such an observation period would amount to several months and should increase with age. During that time, a robust bioage determination would require several data points per recovery time, that is ideally one measurement in a few days.

Wearable technology comes into play

In 2021, the only practical way to achieve a high (once-per-day or better) sampling rate is to use mobile/wearable sensor data.

In another paper, the authors have focused on wearable/mobile sensor data. They have built "wearable DOSI", which they called GeroSense and reported its validation tests in Pyrkov et al. Aging (Albany NY) 13.6 (2021): 7900. GeroSense can be used to compute resilience. Population study shows that the number of individuals showing signs of the loss of resilience increases exponentially with age and doubles every 8 years at a rate matching that of the Gompertz mortality law (the observation by B. Gompertz from 1827, who observed for the first time that the all-cause mortality rate doubles every 8 years).

###

About Gero

Gero is a data-driven biotech company applying modern AI/ML tools to big longitudinal biomedical data to understand aging and major diseases.

Gero AI/ML models are originating from the physics of complex dynamic systems. We have presented our unique approach in Frontiers in Genetics (Fedichev 2018, Frontiers in genetics 9:483). We combine the potential of deep neural networks with the physical models to study human health as a dynamic process. In conjunction with high-quality genetics data, we produce quantitative explanatory models of (aka theory of) aging and complex diseases, as well as actional drug target hypotheses.

Gero conducts high-quality research in collaborations with Harvard Medical School, Massachusetts Institute of Technology, University of Edinburgh, National University of Singapore, Moscow Institute of Physics and Technology, and Roswell Park Comprehensive Cancer Center. The company is a regular contributor to peer-reviewed journals.

Gero has developed a unique framework "GeroSense" for continuous day-to-day monitoring of biological age based on data streams of mobile and wearable sensors. "GeroSense" provides biological age monitoring in our free iPhone app.

Gero encourages using "GeroSense" via web API for monitoring of anti-aging and pro-longevity effects of therapies as well as lifestyle choices, physical activities, diets, food supplements, recommended by health/fitness and wellness apps (see https://techcrunch.com/2021/05/07/longevity-startup-gero-ai-has-a-mobile-api-for-quantifying-health-changes/).

Gero is funded by AI champions, including AIMATTER founders (recently acquired by Google). In 2019 and 2021, Gero was also named one of the leading companies in artificial intelligence in life extension along with Google and IBM.

About Roswell Park Comprehensive Cancer Center

Roswell Park Comprehensive Cancer Center is a community united by the drive to eliminate cancer's grip on humanity by unlocking its secrets through personalized approaches and unleashing the healing power of hope. Founded by Dr. Roswell Park in 1898, it is the only National Cancer Institute-designated comprehensive cancer center in Upstate New York. Learn more at http://www.roswellpark.org, or contact us at 1-800-ROSWELL (1-800-767-9355) or ASKRoswell@RoswellPark.org.

Nature Communications

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In most ways, women age better than men and live longer. Scientists are trying to figure out why. – The Philadelphia Inquirer

Sunday, November 21st, 2021

Consider 100 baby boys and 100 baby girls born in 1950. Experts predict that 46 of the men and 61 of the women a third more will still be alive at age 80 in 2030.

Even Steven Austad, an expert on aging at the University of Alabama at Birmingham, didnt give statistics like that much thought until about 10 years ago. Everyone knew that women outlived men. He figured it was just because men had more heart disease.

But Austad, who is senior scientific director of the American Federation for Aging Research, is a sucker for topics that others take for granted, and he dug deeper. He learned that girls started out-surviving boys even before they were born and that their survival advantage lasted throughout life. It was present in virtually every country, rich or poor. Women were more likely to live through natural disasters, famines, pandemics (including COVID-19) and many of the diseases that most often kill human beings. Under almost any condition we can imagine, women do better, he said.

A rare upside for men was that those who made it to their senior years were less disabled than female peers. There were also surprising studies that found that a few drugs that extended the life of male mice did nothing for females. Thats a really stunning result, said Richard Miller, a biogerontologist who directs the Paul F. Glenn Center for Aging Research at the University of Michigan and has been studying life-extending drugs in mice. One medication, he said, worked in both sexes.

Austad and a growing cadre of researchers started to think that these differences in aging between men and women were fundamental to human biology and potentially much more complex and divergent than many had assumed. They are now in the early stages of studying how our chromosomes and genes, hormones and immune systems influence how long and how well we live, with an eye toward expanding our healthy lifespans.

If we could find a way to make men live as long as women and make women be as healthy as men later in life, then we would have an enormous impact on our lives, Austad said.

Candace Kerr, a stem cell biologist in the division of aging biology at the National Institute on Aging, agreed that understanding these sex differences could improve the health of both men and women as they aged. It paves the way to finding sex-specific targets for disease, she said.

For decades, scientists assumed that information they gleaned from male patients and male lab animals would naturally apply to females, as well. Since 2016, the National Institutes of Health has required scientists to incorporate males and females into the design, analysis and reporting of clinical research studies of people and vertebrate animals.

Now researchers are finding unexpected differences throughout our bodies, but they say its too soon to draw sweeping conclusions. I think that we are in a renaissance of sorts in really beginning to understand and appreciate the differences, said Dena Dubal, a neurologist at University of California-San Francisco who studies how to slow aging with a focus on hormones and genetics. Her research has found fascinating evidence of the benefits women may derive from their second X chromosome.

The signs that women are the tougher sex when it comes to health are copious. Eighty-five percent to 90% of centenarians are women. All of the worlds 10 oldest people with credible birth records were female, Austad said. In 2018, women died at a lower age-adjusted rate of 13 of the top 15 causes of death, according to the National Center for Health Statistics. There was no sex difference for stroke. Women were more likely to die of Alzheimers disease, although men who get dementia die of it more quickly, said Michelle Mielke, a Mayo Clinic epidemiologist who studies sex differences in neurodegeneration.

Women tend to die of the same basic things that men do, but they die at later ages, Miller said.

At the cellular level, womens brains look four to five years younger than mens, Dubal said. Many biological markers indicate faster aging in almost all of the tissues in male bodies, Kerr said. Women get heart disease later. Their vascular health is generally better than mens, although they have more disease in small blood vessels in late life, Mielke said. Womens immune systems respond more quickly to viral invasions. This is one explanation for why theyre more likely to recover. It may also be why theyre more prone to autoimmune diseases than men.

Then we come to what Austad calls the morbidity-mortality paradox. Men who survive into late middle age and old age tend to have less disability than women. One theory is that men die of diseases that women survive, but the women do not emerge unscathed. Many women will survive and remain fairly functional after diseases that men would have died from, Miller said.

Anne B. Newman, a geriatrician and epidemiologist at the University of Pittsburgh, added that women are more prone to arthritis, which causes disability. Everyone loses muscle mass with age, and women start out with weaker muscles and a higher percentage of body fat. Women are also more prone to osteoporosis after menopause, and that puts them at risk for broken hips. There are more older women with frailty, partly because frail men dont live long.

Women are just physically less endowed to keep moving as they get older, Newman said.

READ MORE: It's never too late to start moving, but you may not catch up to lifelong exercisers

As to why women live longer, the theories are many and complex.

The gap between male and female lifespan widened during the 20th century. Caleb Finch, a biologist at the University of Southern California who studied that phenomenon, thought lung cancer and heart disease accounted for most of the difference. He also studied an indigenous Bolivian population whose pre-industrial lifestyle included exercise and a healthy diet. People there had very little coronary artery disease, but men still had more evidence of blood vessel damage than women.

Newman added that women began living longer when better medical care meant they less often bled to death or became infected during childbirth. She thinks that qualities that allow women to successfully carry a child, such as the ability to tolerate stress and store additional nutrition, may lengthen their lifespans.

You cant ignore behavior. Men are more likely to smoke and eat fatty food. Theyre also less likely to see doctors regularly and get cancer screenings and flu and COVID-19 vaccines. They more often age in isolation. Behavior feels like more than half of the picture, said Aroonsiri Howell, a Temple Health geriatrician.

Young men are prone to risky and potentially deadly activities, a period that Austad calls testosterone dementia. Their death rate compared to womens slows after 35 or so, but its still higher.

Finch said trying to tease out whats affecting our aging is like analyzing a hoard of arrows shot into the air at the same time but traveling at different rates. Genes and hormones matter, but the role of culture and society in shaping the outcomes is also huge and not easy to define at the molecular level.

Beyond behavior, much current research focuses on hormones and sex chromosomes. Women have two X chromosomes, one from their mother and one from their father. Men have an X from their mother and a Y from their father.

Those two Xs give women a richer dose of X-related genes. In each cell of a womans body, one X dominates and the other is mostly inactivated, but its not always the same X. Early in life, the mom and dad Xs may split the work fairly evenly, but, as women age, the fitter X may take on a bigger role, Austad said. Plus, scientists now know that the inactivated X isnt really inactivated. About 15% of its genes are functional.

Austad thinks the Y deserves more attention than scientists are giving it, but its clear that it codes for many fewer genes (55) than the X (900). While the second X may give women a safety net of sorts if one of their Xs is faulty, a mans Y chromosome is not much help when theres a problem with his X. This is why certain X-lined diseases, such as fragile X syndrome, hemophilia A, and Duchenne muscular dystrophy are more common in men.

Dubals work with mice suggests that womens extra X complexity also gives women a longevity advantage. She used a technique that allows researchers to grow the gonads of one sex in the bodies of another, thus exposing them to the other sexs hormones. So, genetically female mice could have testicles and penises and male mice could have ovaries and vaginas. She compared four groups of mice: XX mice with ovaries, XX mice with testicles, XY mice with testicles and XY mice with ovaries. The XX mice lived the longest, regardless of their gonads.

The X accounts for about 5% of our genome, Dubal said, and it is rich in brain-related genes. This may help explain why women are more cognitively resilient. One of her studies found that 19 of those genes were associated with slower cognitive aging in women, but not in men. Three genes, meanwhile, were linked to higher levels in men but not women of misformed tau, a protein seen in the brains of people with Alzheimers.

Women may reap the benefits of the double-dose of X throughout their lives, but theres little doubt that things go downhill from an aging perspective after menopause, so hormones are clearly also a factor. Estrogen, the most important female hormone, drops markedly as a woman enters menopause. Testosterone production also slows in men.

Estrogens are thought to be protective against a variety of diseases, whereas testosterone seem to enhance the risk of disease progression, wrote Brnice Benayoun, a geneticist and cell biologist at the University of Southern Californias Leonard Davis School of Gerontology, in a 2020 paper.

The average woman reaches menopause at 51. Studies show that later menopause is associated with longer life.

Jennifer Garrison, a neuroscientist and chemist at the Buck Institute for Research on Aging, focuses on the impact of ovarian aging in women. Menopause makes a womans body age about 6% faster, she said. It unleashes this negative cascade of health effects, including more heart disease, cognitive decline, and bone weakening. She said the ovaries are involved in important communication channels with the brain that have systemic physical implications.

She would like to do away with menopause entirely. Theres no biological imperative to have it, she said. She thinks menopause should be a choice, not something imposed on you by some out-of-date biology. She realizes that not every woman dreams of extra decades of periods and pregnancy fears. Pregnancy and fertility and menstruation can potentially be uncoupled from having functioning ovaries, she said.

No doubt it will take a while to figure out how to do that, and there is no similar fix available to aging men.

In the meantime, Temples Howell counsels male and female patients differently. She tells the men to worry about heart disease and high-fat diets. Women need to worry about preventing osteoporosis and falls.

READ MORE: Steps to prevent falls as we age

And we all can do the usual things that promote healthier aging: Eat good food, avoid smoking and exercise.

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In most ways, women age better than men and live longer. Scientists are trying to figure out why. - The Philadelphia Inquirer

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Embark sponsors The National Dog Show, in commitment to improving life and longevity of all dogs – PRNewswire

Sunday, November 21st, 2021

BOSTON, Nov. 16, 2021 /PRNewswire/ -- Embark Veterinary, Inc., a global leader in dog genetics, today announced that it will be the preferred dog DNA test sponsor of The National Dog Show. Hosted by The Kennel Club of Philadelphia and licensed by the American Kennel Club, the 20th anniversary Thanksgiving Day special will take place at the Greater Philadelphia Expo Center in Oaks, Pa. Nov. 20-21. It will be open to the vaccinated public for the first time since 2019 due to the COVID-19 pandemic.

Embark recently launched the first-ever DNA test for purebred pet owners, leading the dog DNA testing evolution from breed discovery to a personalized pet care necessity. Embark's data shows that 75% of dogs are carriers, or at risk for, a genetic health condition. But, with hundreds of actionable health insights and the most accurate, detailed data on their dog's health, Embark is helping breeders, owners, and veterinarians make proactive choices that address any breed-specific health conditions and traits.

"The National Dog Show Presented by Purina is a Thanksgiving tradition for many families, and we're proud to become a part of that tradition this year," said Embark CEO and Cofounder Ryan Boyko. "One of the silver linings of the pandemic has been the opportunity to better understand, appreciate and bond with our dogs. As families come together to watch The National Dog Show this year, we hope they'll consider learning more about how to improve their dog's health through genetic screening."

Embark aims to extend dogs' lives by three years within the next decade. A key to achieving that goal is building tools that help breeders make better mating pairs that improve the health of their breeding line, offering genetic counseling, and screening for breed-relevant genetic health conditions. Embark salutes the breeders exhibiting at the Kennel Club of Philadelphia dog show and their important work in breed preservation.

"We are looking forward to working with Embark Veterinary in support of the important work that they do for our canine friends, pet parents, and the veterinary community," said Kennel Club of Philadelphia President Wayne Ferguson. "There's great interest in canine genetics and show attendees in Philadelphia will have the opportunity to learn more at the Embark expo booth."

About Embark Embark Veterinary, Inc. was launched in 2015 by two brothers, Adam and Ryan Boyko, who have a passion for scientific research and a lifelong love for dogs. Starting with their best-in-class canine DNA test, Embark is building a powerful platform for scientific discovery that will accelerate advancements in personalized dog care. Embark offers the most scientifically advanced, most trusted, and highest-rated dog DNA tests on the market that helps dog owners, breeders, and veterinarians learn about their dog's breed, health, and ancestry. Customers gain hundreds of actionable insights that inform more proactive care, and every test fuels new research to help all dogs lead longer, healthier lives. Embark is an official research partner of Cornell University College of Veterinary Medicine, was named to the Inc. 5000 list for the past two years, and was included on Forbes' next billion-dollar startups list.

For more information, visit Embark's website at EmbarkVet.com, and follow Embark on Facebook, Twitter, and Instagram.

SOURCE Embark Veterinary Inc.

http://EmbarkVet.com

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Embark sponsors The National Dog Show, in commitment to improving life and longevity of all dogs - PRNewswire

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Inherited Metabolic Disorders Market Study | Know the prominent factors that will help in reshaping the market growth – BioSpace

Sunday, November 21st, 2021

The inherited metabolic disorders market lies mostly with the Caucasian and African American populations of world, especially in North America, Europe, Australia, and Africa, followed by the minority populations from South Asia and East A.

Globally, IMD affects nearly one in every 2,500 to 5,000 individuals with nearly 300 to 600 new cases found in the U.K., according to Public Health Genetics U.K. The specificity and high risk affinity of IMD varies from disorder to disorder, with some disorders like familial cylomicronemia being closely associated with Caucasians and others like porphyria being recoded largely among African Americans. These metabolic disorders are often controllable with certain lifestyle and diet changes, including Familial Cylomicronemia and Phenylketonuria. But some IMDs are highly dangerous and may affect the survivability of a person, such as Huntingtons or Zellweger syndrome.

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A lot of IMDs arise when the mutated gene responsible is inherited by the natural selection process and a large number of these genes are recessive. This is probably why a large number of these metabolic disorders are rare occurrences, whereas certain other genes are dominant in nature; this makes it difficult for a willing parent to conceive a child as the risk for transferring a gene remains high (e.g. Huntingtons). Familial chylomicronemia occurs when an individual genetically inherits Lipoprotein lipase enzyme mutation. This is a very rare genetic disease at occurrence rate of 1 individual per million with chances of symptoms occurring only in homozygous individuals (receiving mutation genes from both parents) or in other words recessive gene transmission.

Global Inherited Metabolic Disorders Market: Current Market Trends

Nowadays, genetic screening via mass spectrometry and DNA testing of all newborn children are done in nearly all of the developed countries and also some developing countries of the world, including India, China, and Brazil, albeit across a small percentage of the national population. This prepares a parent and the child with the necessary precautions and treatment for increasing the longevity of the concerned newborn. The life expectancy of such a child with all the necessary care and precaution is at par with the average individual.

However among many adult populations and in some children, rare genetic metabolic disorders are abruptly presented and often not accurately diagnosed. In such individuals, abnormal metabolic changes are considered to be a type of genetic mutation in routine diagnosis. Symptoms such as growth failure, precocious puberty and development delay in children below 12, and anemia, neurological disorder, cancer, muscle weakness, rapid hormonal changes, and skin changes in adults, are regarded to probably have a genetic metabolic cause.

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Global Inherited Metabolic Disorders Market: Treatment Classifications

The treatment of IMDs is broadly classified into dietary restrictions, dietary supplementation, drugs that inhibit or regulate metabolism, transplantation of the concerned organ, gene therapy, and dialysis in severe cases. In the case of familial cylomicronemia, gene therapy includes Alipogene tiparvovec recombinant gene therapy drug, manufactured by UniQure Inc. This therapy utilizes viruses (adenovirus vector) designed in such a way that upon infection, the gene for producing the lipoprotein lipase is induced into the host cell, thereby producing the enzyme in-vivo. This therapy has shown positive results and is expected to be released into the market soon. For now, the global inherited metabolic disorders Market lies broadly in the dietary supplements market.

Global Inherited Metabolic Disorders Market: Regional Evaluation

The overall estimated global populations of IMD individuals lie in few millions. The niche category of this segment gives little market for specific condition-related products. However, the implications of therapy are huge as some treatments have the potential to completely eradicate these disorders. Several suitable models have been considered for the treatment of hypercholesterolemia and dyslipidemia, which can in turn alter the outcome of cardiovascular diseases to a bare minimum in the future. For now, the inherited metabolic disorders is open for limitless possibilities.

The inherited metabolic disorders lays primarily with the Caucasian and African American populations of world, especially in North America, Europe, Australia, and Africa, followed by the minority populations from South Asia and East Asia.

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Current and Future Threats

Along with studying the opportunities necessary for growth, threats are also an important aspect to look upon for the companies and stakeholders in a specific sector. TMR Research studies every negative aspect that will hinder the growth of a specific area of business and includes it in the report. The stakeholders and CXOs will have the benefit of assessing the threat and take the necessary steps to prevent the hindrance caused due to the threats.

Accurate Trend Analysis

Keeping up with the latest trends is crucial in any business or sector. While stakeholders are aware of the trends that are on the surface, TMR Researchers find trends that are deeply entrenched in the particular market or sector. The reports are constantly updated with the latest trends so that the stakeholders and CXOs can derive benefits from the trends and generate good revenues.

Regional Assessment

Demography forms an important part of the growth pattern of all the markets. Diving deep into the demographics enables maximum output from specific areas. The TMR Research team assesses every region and picks out the vital points that have a large impact on the growth of a market.

Industrial Analogy

The analysts at TMR Research conduct an all-round analysis on the competitive landscape of the market. The observations recorded by the analysts are added to the reports so that every stakeholder gets a glimpse of the competitive scenario and frame their business plans according to the situation.

COVID-19 Impact

The COVID-19 outbreak has changed the growth projections of numerous sectors and businesses. The analysts at TMR Research have conducted a conscientious survey on the markets after the pandemic struck. The analysts have put forth their brilliant and well-researched opinions in the report. The opinions will help the stakeholders to plan their strategy accordingly.

About TMR Research

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

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Inherited Metabolic Disorders Market Study | Know the prominent factors that will help in reshaping the market growth - BioSpace

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Why Hangovers Get Worse as You Age, and What to Do About It – Livestrong

Sunday, November 21st, 2021

For a variety of reasons, it takes your body longer to process alcohol as you get older.

Image Credit: AzmanL/E+/GettyImages

The only thing worse than a fun night of cocktails coming to an end is the morning after: when your mouth is as dry as the Sahara, your head feels like it's being used as a bass drum and your insides are churning. You're no stranger to being hungover, but that's the thing why do hangovers now feel so much worse compared to when you were younger?

There's a reason (well, several), and we'll get there but first, a quick brush-up on what causes hangovers:

"There are many different reasons why hangovers occur, and these are due to both the direct actions that alcohol has on the body as well as the way your body metabolizes and gets rid of the alcohol," Heather Moday, MD, Philadelphia-based physician and author of The Immunotype Breakthrough, tells LIVESTRONG.com.

Usually, hangovers happen as a result of drinking excessive amounts of alcohol, but depending on what you drink, combined with your genetics, weight, overall health and even your sex, you can experience hangovers even after consuming small amounts of alcohol.

Because there are so many potential factors at play, the science behind hangovers and the role age can play in their severity is spotty at best but experts do have a few theories as to why your body doesn't react as well to that pitcher of beer anymore.

1. Your Livers Not Functioning as Efficiently

It's the liver's job to metabolize the alcohol we drink, but as we age, its ability to effectively and efficiently get the job done decreases.

"This might be caused by the fact that there's simply less blood flow going to the liver, which means the body takes more time to expel the alcohol," Hisham Korraa, MD, a psychiatry and detox medicine specialist in Newport Beach, California, tells LIVESTRONG.com.

As a result, the alcohol ends up lingering in the body longer and creating a greater blood alcohol concentration than you'd have otherwise.

2. You Have Less Total Body Water

"For the majority of our lives, the percentage of our body weight that's comprised of water is roughly 50 percent," Dr. Korraa says. "However, this starts to decline as we age, due to the overall body composition changes we experience."

We tend to develop more body fat as we age, which contains less water than lean muscle. It hasn't been proven, but some medical experts believe this can lead to there being a higher concentration of alcohol in the bloodstream, which could contribute to worse hangover symptoms.

3. Youre on Medication

Alcohol is broken down by the liver and so are many medications.

"As we get older, we have less liver enzyme activity, so being on medications while also drinking alcohol creates a competition for these enzymes," Seema Bonney, MD, founder and medical director of the Anti-Aging & Longevity Center of Philadelphia, tells LIVESTRONG.com. "This combination may contribute to more significant hangover symptoms."

Consuming alcohol while taking certain medications can also put you at risk of developing more serious health conditions, due to alcohol getting in the way of your medications breaking down properly: Sedatives become more potent, blood pressure meds aren't as effective and blood thinners can increase the risk of serious bleeding, according to the Cleveland Clinic.

4. Youre More Sensitive to the Effects of Alcohol

Odds are, you booze it up less often compared to when you were younger, thanks to an uptick in career, family and social obligations.

"Consuming alcohol less regularly might cause your body to process it slower," Dr. Korraa says. "A reduced alcohol tolerance, combined with a less productive liver, could potentially worsen hangover symptoms in older individuals."

5. Your Hangovers Might Only Seem Worse

"Because you're likely to drink less than you did when you were younger, your memory of past hangovers may be skewed," Dr. Korraa says.

Hangovers of yore may have been just as brutal as the ones you experience now, but because they're not a series regular in your life anymore and you're no longer used to them, you might perceive them as being more catastrophic.

How Long Do Hangovers Last?

The specific combination of symptoms and how severe they are vary from person to person, but hangover symptoms (headaches, dizziness, fatigue, nausea, vomiting, rapid heartbeat, irritability, anxiety and depression) typically peak when the blood alcohol concentration in the body returns to around zero, with the symptoms lasting roughly 24 hours or longer, according to the National Institute on Alcohol Abuse and Alcoholism.

How to Avoid Feeling Hungover

Drinking on an empty stomach is a recipe for hangover city.

Image Credit: skynesher/E+/GettyImages

Unfortunately, the only foolproof way to avoid a hangover is you guessed it not drinking.

"There's no absolute prevention for hangovers if you choose to drink," Dr. Moday says. "However, there are certain things to keep in mind if you do decide to imbibe."

Read on for steps you can take to make hangovers more manageable and maybe even avoidable.

1. Choose Your Drink Wisely

In terms of which alcohols may cause more hangovers, this is somewhat individual. But generally speaking, some people are sensitive to the natural tannins in red wine (chemical compounds derived from the skin, stems and seeds of grapes), as well as the added sulfites (which preserve the freshness of wine and protect it from oxidation), Dr. Moday says.

If your hangovers seem to be especially monstrous after having wine, opt for low-tannin wines like merlot, pinot noir or zinfandel, or varieties that don't contain sulfites.

Prefer liquor or beer? Avoid darker drinks, which tend to contain more congeners chemicals produced during the fermentation process.

"Higher amounts of congeners can be found in drinks like brandy, bourbon and dark ales," Dr. Korraa says. "Lighter drinks, such as gin, vodka and light beers typically have less of this chemical and are thought to be easier for the body to process, lessening the symptoms of a hangover."

2. Dont Drink on an Empty Stomach

If you eat before and while you drink, your body won't absorb the alcohol as quickly as it would on an empty stomach.

"The majority of alcohol is absorbed into the bloodstream through the small intestine," Dr. Korraa says. "If you consume a hearty meal before drinking, the alcohol will stay in your stomach longer, which means it'll be absorbed more slowly and alleviate some of the hangover side effects."

Drinking alcohol faster than your body can process it can overwhelm your system and lead to a worse hangover the next day. Spacing out your drinks might mean the difference between a mild headache and feeling like you've been hit by a bus.

"A healthy liver can process one drink per hour maximum," Dr. Moday says, so consider reading the label on your drink du jour or eyeing the volume of your glass to avoid going overboard.

One drink equals:

4. Alternate Between Booze and Water

When you drink alcohol, you may have noticed that you have to go to the bathroom more than normal.

"Because alcohol's a diuretic, you often end up expelling more liquid than you take in when you're drinking," Dr. Korraa says. Cue dehydration, which increases the odds you'll experience a bad headache, fatigue, weakness and more the following day.

For every alcoholic bevy you have, have a non-alcoholic one to balance the scales. "Doing so will increase your body's water content, which will lower your alcohol concentration," Dr. Bonney says. "It doesn't counter the absorption of alcohol but does slow it down."

5. Get a Jump on Nursing Your Hangover

While there's no guarantee, there are a few steps you can take right after drinking to potentially lessen your chances of a bad hangover the next day.

First up, do your best to finish drinking at least four hours before you go to bed. You might fall asleep faster with alcohol still in your system, but once the alcohol starts to metabolize and the sedative effect wears off, you risk waking up too early and not being able to get back to sleep.

You should also start the process of replenishing your body with fluids. "Be sure to drink a tall glass of water before going to bed," Dr. Korraa says. "You can also drink a sports drink to give your body a boost of electrolytes."

And even if the thought of eating something makes you queasy, it might be a good idea to get something bland in your system to help absorb some of the remaining alcohol in your stomach, Dr. Korraa adds. Try eating at least a plain piece of toast before calling it a night.

You should continue to rehydrate the following day. Tired of plain water? Guzzle some Gatorade or Pedialyte for a one-two punch of H2O and electrolytes.

Do your best to resist any ravenous cravings for greasy foods it's probably your blood sugar talking. Instead, opt for a breakfast that contains protein, carbs and healthy fats to bring your blood sugar back into balance.

"A nutritious breakfast with eggs, spinach, toast, bananas, avocado or oatmeal will be kinder to your stomach and may help reduce your hangover symptoms," Dr. Korraa says.

Lastly, go easy on yourself. Take time out to legitimately rest after your night of debauchery. "There's no cure for a hangover, and you truly just have to let it run its course," Dr. Korraa says. "Be kind to your body and know you'll be back to normal soon."

Link:
Why Hangovers Get Worse as You Age, and What to Do About It - Livestrong

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Addicted to coffee? Heres how it can be harmful to your health – Khaleej Times

Sunday, November 21st, 2021

Study also shows beneficial short-term health effects

By ANi

Published: Sat 20 Nov 2021, 6:20 PM

Last updated: Sat 20 Nov 2021, 6:33 PM

Coffee is the most commonly consumed beverage in the world, yet its health effects remain uncertain, says Gregory Marcus, M.D., M.A.S., associate chief of cardiology for research and endowed professor of atrial fibrillation research at the University of California, San Francisco.

While the majority of long-term observational studies have suggested multiple potential benefits of drinking coffee, this is the first randomised trial to investigate the real-time, physiologic consequences of coffee consumption.

A new research has found that caffeinated coffee consumption can have both beneficial and harmful short-term health effects.

The findings were presented at the American Heart Associations Scientific Sessions 2021.

The meeting was fully virtual Saturday from November 13-Monday to November 15, 2021, and was a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science for health care worldwide.

Marcus and colleagues enrolled 100 adult volunteers, and they were assigned to wear continuously recording ECG devices (to track heart rhythm), wrist-worn devices to track physical activity and sleep; and continuous glucose monitors to track blood sugar levels for two weeks. The participants were an average age of 38 years, 51 per cent were women and 48 per cent were white. Researchers also obtained DNA saliva samples from the participants to assess genetic variants that may affect caffeine metabolism.

ALSO READ:

Participants were then randomly assigned to either avoid or consume coffee for no more than two consecutive days each for 14 consecutive days. Coffee and espresso consumption were recorded in real-time via a timestamp button on the ECG monitor, and researchers tracked trips to coffee shops with geotracking. In addition, participants completed daily questionnaires to detail how much coffee they had consumed every morning.

The analysis found that coffee consumption was associated with a 54 per cent increase in premature ventricular contractions, a type of abnormal heartbeat originating in the lower heart chambers reported to feel like a skipped heartbeat. In contrast, drinking more coffee was associated with fewer episodes of supraventricular tachycardia, an abnormally rapid heart rhythm arising from the upper heart chambers.

Consuming coffee was consistently associated with more physical activity as well as less sleep. Specifically:

- Participants who consumed coffee logged more than 1,000 additional steps per day compared to days when they did not drink coffee.

- On the day participants drank coffee, they had 36 fewer minutes of sleep per night according to their Fitbit devices.

- Drinking more than one coffee drink more than doubled the number of irregular heartbeats arising from the hearts lower chambers.

- Each additional cup of coffee consumed was associated with nearly 600 more steps per day and 18 fewer minutes of sleep per night.

- There were no differences in continuously recorded glucose measured when the study participants consumed versus avoided coffee.

These findings were corroborated by analyses of adherence to their randomization assignment and amplified when more versus less coffee was consumed.

ALSO READ:

More physical activity, which appears to be prompted by coffee consumption, has numerous health benefits, such as reduced risks of Type 2 diabetes and several cancers, and is associated with greater longevity, Marcus said. On the other hand, reduced sleep is associated with a variety of adverse psychiatric, neurologic and cardiovascular outcomes. More frequent abnormal heartbeats from the upper heart chambers influence risk of atrial fibrillation, and more frequent abnormal beats from the lower chambers, or ventricles, increase the risk of heart failure. These results highlight the complex relationship between coffee and health.

The study participants with genetic variants associated with faster caffeine metabolism exhibited more abnormal heartbeats originating in the ventricles, or PVCs when more caffeinated coffee was consumed. The slower an individual metabolises caffeine based on their genetics, the more sleep they lost when they drank caffeinated coffee.

The investigators also sought to determine if changes in exercise or sleep influenced coffees effects on abnormal heart rhythms, and no such association was identified.

Marcus noted that because coffee was randomly assigned to the study participants, cause-and-effect can be inferred. These observations were made during repeated assessments of days when coffee was consumed versus when it was not for each study participant, eliminating concerns regarding differences in individual-level characteristics as an explanation for these results.

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Addicted to coffee? Heres how it can be harmful to your health - Khaleej Times

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