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Archive for the ‘Integrative Medicine’ Category

POTUS India visit: Trump expected to talk Kashmir,says US Officials – The Kashmir Monitor

Saturday, February 22nd, 2020

New Delhi, Feb 22: In a bid to address the concerns of the local populace after the revoking of Jammu and Kashmirs special status last year, Union Minister Jitendra Singh on Saturday assured the people of the Union Territory that the domicile law is coming very soon which would be followed by the Land Act.He also announced that more than the promised jobs will be provided to the youth after the notification of the rules is worked out.The domicile act is coming very soon, which will be immediately followed by the Land Act, the minister of state in the Prime Ministers Office said.Many parties have been demanding enactment of a domicile law for Jammu and Kashmir to protect the interests of landowners and the unemployed youth after the erstwhile state lost its special status following nullification of Article 370 by the Centre.Singh was addressing a function after signing of a major scientific collaboration agreement between CSIR-Indian Institute of Integrative Medicine, Jammu, and IndusScan, a Canadian pharmaceutical company, here.Describing the signing of the MoU as a historic moment, the minister said Jammu and Kashmirs journey to become a part of Indias five trillion global economy has started from the four walls of IIIM.Prime Minister Narendra Modi is saying again and again that we would have the same kind of focus on Jammu and Kashmir and Ladakh as we did for North-East which saw major transformation over the last five years. Those who have doubts about it would see all this happening in a short while of time, he said.The minister said this is possible because the earlier embargoes have been removed and the Union Territory is directly reporting to the Centre.Many of the politicians have become unemployedheard yesterday one of them raising the issue of jobs to the local youth. I want to tell that more than the promised jobs will be advertised but as per the rules and in an impartial manner. We are waiting for a notification of the rules to come out, he said.Alleging brazen disregard for the concerns of the educated unemployed and underemployed youth by the incumbent government, National Panthers Party Chairman and former minister Harsh Dev Singh had said not a single post, out of the promised 50,000 jobs, had been advertised for filling up in the new UT after the abrogation of Article 370 provisions.Everything will be done. It will not be like when your government was in power and ruined the future of the youths by backdoor appointments and corrupt practices. The youth who were provided jobs have turned 35 years but are still waiting for their regularisation, the Union minister said.He said the jobs will be provided under rules which will be in the best interest of the youth and those who have been deprived of it.Asserting that India is going through one of the best phases under the leadership of Modi, he said a lot of development had taken place over the last five years and the country is looking forward to become a part of the global economy.On the one hand India is eyeing five trillion economy, dont you want that Jammu and Kashmir should also be part of that. It is possible only when our youth reaches such a stage to live up to the parameters which are followed globally and therefore, even if some of us have any doubts, confusion and skepticism or still unconvinced, ask themselves that dont you want your children to be part of five trillion economy.If you understand it, I think all the murmuring and whispering which is generated from thoughtless minds will vanish away, Singh said.The minister said Jammu and Kashmir is also under the process of a new industrial policy and a new scientific policy.The greatest disadvantage that has happened from Jammu and kashmir remaining in isolation because of Article 370 is that we become lazy and lethargic. We learnt to live on easy freebies, he said.

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POTUS India visit: Trump expected to talk Kashmir,says US Officials - The Kashmir Monitor

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Nine dead, five injured in Kathua mishap – The Kashmir Monitor

Saturday, February 22nd, 2020

New Delhi, Feb 22: In a bid to address the concerns of the local populace after the revoking of Jammu and Kashmirs special status last year, Union Minister Jitendra Singh on Saturday assured the people of the Union Territory that the domicile law is coming very soon which would be followed by the Land Act.He also announced that more than the promised jobs will be provided to the youth after the notification of the rules is worked out.The domicile act is coming very soon, which will be immediately followed by the Land Act, the minister of state in the Prime Ministers Office said.Many parties have been demanding enactment of a domicile law for Jammu and Kashmir to protect the interests of landowners and the unemployed youth after the erstwhile state lost its special status following nullification of Article 370 by the Centre.Singh was addressing a function after signing of a major scientific collaboration agreement between CSIR-Indian Institute of Integrative Medicine, Jammu, and IndusScan, a Canadian pharmaceutical company, here.Describing the signing of the MoU as a historic moment, the minister said Jammu and Kashmirs journey to become a part of Indias five trillion global economy has started from the four walls of IIIM.Prime Minister Narendra Modi is saying again and again that we would have the same kind of focus on Jammu and Kashmir and Ladakh as we did for North-East which saw major transformation over the last five years. Those who have doubts about it would see all this happening in a short while of time, he said.The minister said this is possible because the earlier embargoes have been removed and the Union Territory is directly reporting to the Centre.Many of the politicians have become unemployedheard yesterday one of them raising the issue of jobs to the local youth. I want to tell that more than the promised jobs will be advertised but as per the rules and in an impartial manner. We are waiting for a notification of the rules to come out, he said.Alleging brazen disregard for the concerns of the educated unemployed and underemployed youth by the incumbent government, National Panthers Party Chairman and former minister Harsh Dev Singh had said not a single post, out of the promised 50,000 jobs, had been advertised for filling up in the new UT after the abrogation of Article 370 provisions.Everything will be done. It will not be like when your government was in power and ruined the future of the youths by backdoor appointments and corrupt practices. The youth who were provided jobs have turned 35 years but are still waiting for their regularisation, the Union minister said.He said the jobs will be provided under rules which will be in the best interest of the youth and those who have been deprived of it.Asserting that India is going through one of the best phases under the leadership of Modi, he said a lot of development had taken place over the last five years and the country is looking forward to become a part of the global economy.On the one hand India is eyeing five trillion economy, dont you want that Jammu and Kashmir should also be part of that. It is possible only when our youth reaches such a stage to live up to the parameters which are followed globally and therefore, even if some of us have any doubts, confusion and skepticism or still unconvinced, ask themselves that dont you want your children to be part of five trillion economy.If you understand it, I think all the murmuring and whispering which is generated from thoughtless minds will vanish away, Singh said.The minister said Jammu and Kashmir is also under the process of a new industrial policy and a new scientific policy.The greatest disadvantage that has happened from Jammu and kashmir remaining in isolation because of Article 370 is that we become lazy and lethargic. We learnt to live on easy freebies, he said.

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Nine dead, five injured in Kathua mishap - The Kashmir Monitor

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IIT Gandhinagar to organise International Conference on Urban Transformations, Youth Aspirations and Education in India – India Education Diary

Saturday, February 22nd, 2020

Gandhinagar: Indian Institute of Technology Gandhinagar (IITGN) and the National Institute of Educational Planning and Administration (NIEPA), New Delhi, are jointly organising an International Conference on Urban Transformations, Youth Aspirations and Education in India on February 20-21, 2020. The two-day conference intends to evolve an inter-disciplinary engagement on the nature of urban transformations and the youth in India while understanding policy dynamics in these areas. It will also attempt to understand the challenges to educational access and skills provision for the youth and the constraints of rural-urban migration, social caste background, and peri-urban locations.

Dr Bhushan Patwardhan, Vice Chairman, University Grants Commission (UGC), New Delhi, will be the Chief Guest at the inaugural program. Dr Patwardhan is a biomedical scientist and a Fellow of National Academy Sciences (India) and National Academy of Medical Sciences (India). He has worked on several policy making bodies including Task Forces of National Knowledge Commission, Planning Commission and has been a consultant to the World Health Organization, Geneva. He is Editor-in-Chief of the Journal of Ayurveda and Integrative Medicine published by Elsevier and is on the Editorial Boards of many reputed Journals. He will speak at the Inaugural Panel on Education along with Prof Sudhir Jain, Director, IIT Gandhinagar; and Prof Pankaj Chandra, Vice Chancellor, Ahmedabad University.

There will also be two keynote lectures on each day of the event. Prof Craig Jeffrey, Professor of Geography at the University of Melbourne, Australia and Director, Australia India Institute, will deliver the first Keynote Lecture titled Fresh Contact: Empowering Youth Innovators in South Asia on February 20. Prof Jeffrey is the author of the book Time pass: Youth, Class and the Politics of Waiting, which is a study of youth which is a study of youth aspirations in small-town North India. The second Keynote Lecture will be delivered by Prof John Harriss, Professor Emeritus of International Studies, Simon Fraser University, Canada, titled Aspiration, Opportunity, Mobility: the prospects for development among Indias youth, on February 21.

The first day of the conference will also have a short film screening titled Lifelines: documenting social change in the Indian Himalayas by Jane Dyson, Professor Anthropology at the University of Melbourne.

Many scholars and experts from India and abroad are invited as speakers during various sessions that will cover a wide range of subjects such as Educational Conundrums of Indian Youth; Youth and Political Mobilisation; Studying the Youth: Methods and Approaches; Peri-urban/Small Town Youth Aspirations; and Urban Landscapes: Marginality and Circulation.

Postgraduate and doctoral students, senior undergraduate students, faculty and researchers in Humanities and Social Sciences from all over the country are going to participate in this international conference. More details about the conference and speakers can be found on the conference website: http://events.iitgn.ac.in/2020/UTYAEI/index.php

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IIT Gandhinagar to organise International Conference on Urban Transformations, Youth Aspirations and Education in India - India Education Diary

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Second batch of Union ministers to visit JK in April – The Kashmir Monitor

Saturday, February 22nd, 2020

New Delhi, Feb 20: The second batch of about 40 Union ministers is likely to visit Jammu and Kashmir in April to get first-hand information about various development schemes initiated thereby both the central government and the Union Territory administration, officials said on Thursday.

The PrimeMinisters Office (PMO) will decide the composition of the ministerialdelegation that will undertake the follow up of the first visit of 37 Unionministers, who had toured Jammu and Kashmir last month.

A secondbatch of about 40 Union ministers may undertake a visit to Jammu and Kashmir.Dates and composition of the team have not been fixed yet but it will be donesoon after the Budget session of Parliament, a government official said.

After the recess,the second part of the budget session will begin on March 2 and it will end onApril 3.

The PMO willfinalise the list of the ministers and each minister will be assigned aparticular district and focus will be on the Kashmir Valley, the official said.

Some of theministers of the first batch may also be part of the second batch, he said.

The ministerswill assess the development initiatives undertaken by the central government aswell as the UT administration on the ground and they will not talk aboutpolitical issues, the official said.

By interactingwith the locals, they will try to get first-hand information about the roads,healthcare facilities, power situation, functioning of academic institutionsetc. in the UT, he added.

As many as 37central ministers had visited Jammu and Kashmir last month following a directiveof Prime Minister Narendra Modi, who wanted an honest assessment of the variouswelfare schemes being implemented there.

Among those whohad visited Jammu and Kashmir were Law Minister Ravi Shankar Prasad, SportsMinister Kiren Rijiju, ministers of state for home G Kishan Reddy and NityanandRai.

The Unionministers have already submitted their feedback to the PMO on theimplementation of various development schemes there.

There were twosets of feedback one on the initiatives taken by the UT administration andthe other on the Centres initiatives another official said.

Most of thecentral ministers stayed overnight at their respective places of visit such asBaramulla, Ganderbal, Doda, besides others.

In August lastyear, the Centre abrogated Article 370 provisions of the Constitution, whichgave a special status to the erstwhile state of Jammu and Kashmir, andbifurcated it into UTs Jammu and Kashmir, and Ladakh.

Since then, theCentre has been closely monitoring the on the ground implementation of variousdevelopment programmes there.

Jammu and Kashmiris currently under the Presidents rule.

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Second batch of Union ministers to visit JK in April - The Kashmir Monitor

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It’s Time the AYUSH Medicinal Systems Developed a New Vocabulary – The Wire

Saturday, February 22nd, 2020

The recent advisory from the Ministry of AYUSH on treatments available in traditional medicine against the new COVID-19 epidemic rightfully created an uproar. There is no scientific evidence that the prescribed medicines work. Indeed, at the time all classical medical texts were collated, people didnt have an understanding of a virus. What there was instead, and which still guides treatment in these medical systems, is a holistic plant-based approach to managing symptoms; in the case of the advisory, for respiratory conditions. So why did the ministry publish unscientific statements? And what drives the almost instantaneously binary reaction to claims from traditional knowledge practices?

To answer this, its necessary to understand the history of medical education in India. Like all education before colonial times, Ayurveda too was also taught in the guru-shishya parampara, a system in which the student was immersed in the gurus household and practice, with a strong hands-on training component. Modern medicine came with the colonialists. In 1822, instructions in western and Indian medicine (Unani and Ayurveda) commenced in Calcutta, but by 1835 Thomas Macaulay effected a policy to withdraw support for instructions in native languages as well as for native medical practices.

Hereon, the colonial and later Indian governments undertook investments to increase the number of medical colleges offering education in western medicine in the country. The Medical Council of India Act of 1956 institutionalised this process, and has since decided on the MBBS degree curriculum. Meanwhile, it was predominantly princely endowments that helped the Indian state setup institutions to train students in traditional medicine. The Maharaja of Travancore had established one of the oldest in 1889 in Thiruvananthapuram, and which has since become the Government Ayurveda Medical College. However, it was not until 1970, with the passing of the Indian Medicine Central Council Act, that Ayurveda and Unani training became institutionalised.

This regulatory divide at the top ensured that from the very start of professional training, modern and traditional medical practitioners are kept separated. To this day, an MBBS degree includes no courses in traditional medicine and vice versa, although Ayurveda doctors do study modern anatomy and physiology. While modern biological sciences like biochemistry, genetics, microbiology, etc. are part of an MBBS education, they find no mention in a BAMS degree. Each group is siloed off, and further divided by socio-cultural imprints, with a rather ungenerous alternate label attached to traditional medicinal practices. Even on campuses that have a cluster of excellent science research departments, there is no exchange of staff and students between the Ayurveda college and the rest of the sciences. Structural bifurcation doesnt stop at medical education: it also extends to biomedical research.

Also read: How the Calcutta Medical College Led to the Rise of Biomedicine in India

In 2014, the government decided to hive off what was until then the Department AYUSH as a separate ministry to boost teaching, research and engagement with Indias traditional medical systems. This would have been an excellent policy decision had it not resulted in programmes where, once again, researchers and practitioners of modern biology are not actively involved in grant-giving committees or policy discussions. Its almost certain that the AYUSH ministry did not run their new advisory by any virologist in the country either, not because there arent any but because they dont feature on their rolodex of experts.

Thus we have a treasure trove of information on medical practices that have not been examined in a system that we know as the scientific method. The practice of testing hypotheses and rigorously demonstrating cause and effect has not permeated AYUSH. A favourite refrain of traditional medical practitioners is that it is difficult to perform clinical trials in the strict reductionist approach of modern science because, by philosophy, traditional medicine is personalised.

This is only the start of differences in vocabulary that then precipitate a binary situation: either believe in traditional medicine or dont. But what if we removed belief from this conversation? We must embrace openness and look for commonalities, the most important being that both streams are about saving lives and improving the quality of life. Modern medicine needs to acknowledge that it doesnt have a treatment for all diseases just as much as traditional medicine needs to acknowledge the same thing. We need more conversations between practitioners and researchers of both medical streams to start unpacking the potential of integrative treatments: the success of traditional medicine for chronic illnesses plus the superior surgical skills and life-saving technologies of modern medicine.

Further, we need to reimagine clinical trials to include personalised approaches to healing with metrics that include formulations as well as single chemical entities. We need the participation of the research fraternity, from biologists to statisticians and engineers, to describe new metrics to measure the efficacy of traditional medicine. Unfortunately, the only way an Ayurveda vaidya interacts with these professions today is in the form of a patient.

A lack of cohesive policymaking that aims to rigorously evaluate and integrate knowledge streams for human wellbeing is preventing us from reaping the full potential of the two. Remarkably, the Charaka Samhita, a basic textbook in Ayurveda, describes a good physician as one who is dynamic and constantly evolving. Its time to take this classical advice seriously.

Megha is an assistant professor at the Centre for Ayurveda Biology and Holistic Nutrition, The University for Trans-Disciplinary Health Sciences and Technology, Bengaluru. The views expressed here are personal.

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It's Time the AYUSH Medicinal Systems Developed a New Vocabulary - The Wire

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Cannabis and integrative medicine in Canada – Health Europa

Saturday, February 8th, 2020

Dr Dani Gordon is a double board-certified medical doctor, working with integrative medicine, as well as wellness expert and leading expert in clinical cannabis/cannabinoid medicine after treating 2500+ patients in Canada in a referral complex chronic disease practice where she specialised in neurological disorders, chronic pain and mental health conditions.

She speaks internationally on cannabinoid medicine and in mid-2018 moved to London to train the UKs first cannabis medicine specialist physicians, developing a leading online cannabis medicine physician training programme, helping to set up the UKs first cannabis medicine clinics and become a founding member of the UK Medical Cannabis Clinicians Society (MCCS), delivering the MCCS guidelines to 10 Downing Street.

Gordon is an American Board Specialist in Integrative Medicine, the newest American sub-specialty of mainstream medicine, focussed on the intersection of conventional and natural evidence-based medicine and therapeutics and she has studied herbal medicine and meditation extensively throughout India and south east Asia with traditional teachers, mind-body medicine at Harvard, neurofeedback brain training and EEG brain imaging techniques with leaders in the field in North America.

Here, she speaks to Health Europa Quarterly about her extensive background in cannabis medicine, patient experience, and the representation of women in the rapidly evolving industry.

I am medical doctor and Im trained in both integrative medicine, which is natural evidence-based medicine and a recognised speciality. I am also trained in family medicine in Canada, and I specialise specifically in herbal medicine, cannabinoid medicine as part of my integrative medicine practice.

I have been practising integrative medicine for the last decade in Canada and that is mostly what I do in my clinical practice. Around four years ago, I started experimenting with medical cannabis and I have been running a complex chronic disease clinic with a focus on medical cannabis for the last four years in Canada; at this point I have treated thousands of patients using medical cannabis and CBD.

I have also trained medical students, physicians and allied health care providers on how to use cannabis medicine. I am a writer, and I speak worldwide on cannabis medicine and other natural evidence-based medicine topics and integrative medicine. Last year I relocated back to the UK where Im also a citizen to get involved on this side of the pond.

Since that time, Ive been involved in quite a few major projects here, I advise on some of the high profile child epilepsy cases, and Im the vice chair of the Medical Cannabis Clinicians Society. I advise companies and I have overseen training the first group of UK specialist doctors in cannabis medicine along with overseeing the curriculum for the Academy of Medical Cannabis, which is the main body established to educate physicians and researchers on medical cannabis.

Integrative medicine is a subspecialty which started out in the States. I already had my postdoctoral fellowship and you already need to be a doctor to take the fellowship programme. Its a two-year fellowship which I completed in 2012 in the US, and the reason I decided to do it is because I was practising as a holistic medical doctor in Canada. I was already a conventionally trained medical doctor with the qualifications I had, but I wanted to add to my practice natural things such as herbal medicine, mindfulness-based stress reduction techniques and mind- body techniques for the benefit of my chronic disease patients.

I went to the states and completed this training in 2012, because there was no postdoctoral level training in natural medicine and I really wanted to have the most bona fide qualification. Since 2012, it has now become a fully recognised speciality in medicine in the US. Initially I wasnt interested in integrative medicine when I started my practice in 2009 as a family doctor helping people with chronic disease was my main interest. I realised that just using pharmaceutical drugs alone for complex chronic diseases, were not really cutting the mustard so to speak. It just wasnt really working very well for a lot of my patients with anxiety, stress related disorders, mental health conditions, fibromyalgia, chronic fatigue syndrome, chronic pain and sleeping problems. Pharmaceutical drugs were just not helping enough on their own.

I became interested in cannabis specifically in 2015. At that time, I had been practising with herbal medicines and conventional drugs for almost half a decade. A lot of my patients started to tell me about their experiences with using cannabis therapeutically because I practised herbal medicine as well as the conventional kind.

I was really interested in the things they were doing, for example some of my patients were juicing cannabis in its raw form and saying that it didnt make them feel high. They explained that it was really a health supplement that their parents generation had been using it in West coast Canada where a lot of people grow cannabis on their land. That got me really interested in why they were juicing it and not getting high and what was what was happening with this plant; as a herbalist I became very intrigued.

I also had a few patients who were at the end of their life with terrible cancers and they told me how they were taking homemade cannabis tinctures to help reduce their morphine needs so that they could be more aware and alert. It allowed them to manage their pain, experience better quality of life and spend more time with their families in their final days.

I started to investigate it from there to find out how I could introduce it into my practice, so people wouldnt need to experiment with it alone and in isolation. I sought out additional training in cannabis medicine, and just found a few mentors but back in 2015, there really wasnt that much awareness. I started opening my door to cannabis medicine being included in my practice through the Health Canada legal system and I just started learning hand in hand with my patients. I was reading all the latest research and working with the plant just as I did with all my other herbal medicine practise. I started to see all these incredible changes in my patients so that really spurred me on to continue.

When I first started out in cannabis medicine, I was actually quite sceptical because I had a lot of ingrained training from medical school that cannabis was an addictive drug that it was going to make people lazy, hurt their brains and make them more tired.

What I found was the patients who were in orphan disease categories with conditions such as fibromyalgia, chronic fatigue syndrome, chronic anxiety and chronic depression, chronic pain were improving when nothing else we had tried previously was really effective. When I started to study the endocannabinoid system, which is the cannabis system we have in our own bodies It made sense because essentially the cannabis plant regulates our own cannabis system which is involved in processes such as regulating our mood and pain signals.

We [doctors and researchers specialising in cannabis medicine] think that a deficient endocannabinoid system also known as Endocannabinoid Deficiency Syndrome theory may play a role in all of these overlapping symptom clusters that are very, very difficult to treat. Conditions such as irritable bowel syndrome, fibromyalgia, chronic daily headaches, chronic migraine, chronic depression and anxiety all these issues sometimes improve using traditional drugs, but it usually doesnt provide a good solution with few side effects.

What I started to do with cannabis is adding in different forms of cannabis medicines primarily the low THC and high CBD strains of the plant and then selecting different strains of the plant more specifically. I found with my background as a herbalist I was able to really personalise the therapy.

With many of my patients who suffered from chronic mental health conditions, I really wanted to get them practising something called Mindfulness Based Stress Reduction (MBSR) which I went to Harvard to study alongside some of the top researchers in the world. I really believe in it; however, it is not a quick fix. Unfortunately, people with chronic pain and chronic mental health conditions are often so poorly that they cant summon the mental effort to keep the practise going long enough for it to start working.

Once I got them onto cannabis, even the low THC cannabis which did not make them feel high, I started to get them to use it before their mindfulness or meditation practise. I found that they started to do more mindfulness and from there they started to exercise more because they werent fatigued. Many patients started to lose weight and become more social; it was kind of a snowball effect that allowed them to do a lot of other things. It allowed them to engage with a lot of non-drug therapies such as CBT that they couldnt engage with before because they were too ill.

I think its been enormously important to the patient experience and I have to say that it has reinvigorated my love of medicine in many ways. It is the kind of medicine that is very well tolerated by most people and helps them with their quality of life so greatly, even though it doesnt cure their condition.

We dont know that cannabis cant cure things and maybe one day we can figure that out, but for now its about quality of life. It has changed my patients lives in ways I could never imagine. Nobody Ive ever prescribed an antidepressant to has ever said to me this has changed my life, but daily and weekly in my practice, I get letters from patients and verbal testimonials that starting them on cannabis has saved their marriage, or completely changed the relationship they have with their children because they can engage with their family life again.

I have seen patients who were so debilitated by very advanced arthritis that they couldnt work or play music anymore and they are able to go back to those things. I had one patient who surprised me with a concert; he hadnt played in 10 years and he was very depressed because his hands were so painful.

I have seen ranchers who live out in the middle of the countryside in Alberta who couldnt get on their horse anymore to round up their cattle and when I did a follow up consultation via a video app, they took me with them on a ranch ride for the first time in five years. It had been five years since theyd been on the horse.

Ive treated young adults with epilepsy who had been told that they would never be independent and that they were going to be in a care home for the rest of their lives, and seen them be able to go to a part time job and get an animal to keep them company these things were not possible before. It changes the whole familys lives not just the person with epilepsy. As far as a single thing I can give someone, although its not a cure it has been the single most powerful tool that I have found so far since going from a Western medicine doctor to a herbal medicine doctor.

One of the things that I get very excited about is changing the perception of cannabis because I think the old perception of cannabis was this kind of stoner culture. On the recreational side of cannabis, which is very different to the medical side. Its not a very wholesome image.

The images that were portrayed of women were often women in bikinis smoking cannabis which are not necessarily positive images of women in general and definitely not the image of cannabis the medicine as I practise it. I feel very lucky to be involved in kind of seeing the transformation of the image of the plant because a hundred years ago, it was a perfectly respectable botanical medicine and its coming full circle back to that.

I feel that women have played a large role in that to be honest, and really introducing a balanced movement into the modern era. It isnt just me, there is Hannahs Deacon, Alfies mother and Charlie Caldwell these are the women who have had kids with epilepsy and have had to fight for access to the treatment. Carly Barton is a good friend of mine and a patient advocate. I have needed and developed a network of women and through social media many of them have become my friends. I think it has been a powerful tool for connecting and empowering women.

One thing that you do find when you enter the business side of the cannabis world is a lot of the people may have come from a traditionally male dominated industry. Often, when I go to give a talk, I will be one of the only women there, but I do feel that is already changing. It is certainly the case that as with many male dominated, corporate professions, women are generally underrepresented which is something needs to be taken seriously; we might potentially have to work harder than men.

Dr Dani GordonIntegrative Medicine Specialistdrdanigordon.com

Please note, this article appeared in issue 11 ofHealth Europa Quarterly, which is available to read now.

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Cannabis and integrative medicine in Canada - Health Europa

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Vibroacoustic Therapy Shows Brain and Sleep Quality Benefits in Clinical Trial for Insomnia – Sleep Review

Saturday, February 8th, 2020

Many people find it easier to sleep in a car or a train because of the vibration and noise that helps rock them to sleep. But a more specific approach for using a vibratory and auditory stimulation program helps improve brain function and sleep amount and quality in patients with insomnia, according to a study published in the journal Sleep Disorders.

Using fMRI scans, the study found improvements in the functional connectivity in the brain as well as in measured amount of minutes slept and self-reported sleep quality. The areas of the brain that were affected were a combination of areas that are involved in sleep itself as well as areas that have improved function as the result of having better sleep. Such an approach might be particularly useful for people with insomnia by helping them to improve their amount and quality of sleep. The study was performed by the Department of Integrative Medicine and Nutritional Sciences, as well as the Departments of Neurology and Radiology, at Thomas Jefferson University.

Approaches that use a combination of vibratory and auditory stimulation have the goal of matching the brains natural rhythms and help improve the amount and quality of sleep. Another goal is to help improve the brain areas affected by a lack of sleep. The current study found changes in areas of the brain associated with both auditory and vibratory sensation. In addition, areas such as the thalamus and prefrontal cortex, which are critical for memory and cognition, were also affected. The current study tested this by tracking changes in functional connectivity using resting state fMRI.

This study is essential for understanding how vibratory and auditory stimulation can improve sleep amount and sleep quality in insomnia patients, says senior author on the paper Daniel Monti, MD, chairman of the Department of Integrative Medicine and Nutritional Sciences and Director of the Marcus Institute of Integrative Health at Thomas Jefferson University, in a release. The study shows how the intervention has a direct effect on vibratory and auditory processing areas of the brain, as well as on important cognitive areas that are impaired when people dont get enough sleep,

This study evaluated 30 patients with insomnia symptoms who continued their current treatments and were placed into two groupsthe first group received the auditory and vibratory stimulation for approximately one month; and the second group, the control patients, received only their standard-of-care treatment for insomnia for the same time period. Those patients in the active group were given an auditory stimulation program, lasting approximately 60 minutes that they used each night as they went to sleep. In addition, they came into the Marcus Institute of Integrative Health twice a week to receive a combination of vibratory and auditory stimulation for 24 minutes using a specially designed chair that merges the two stimuli. This combination of the vibration and auditory stimulation during the day, coupled with the auditory stimulation during sleep, is supposed to help the brain enter the sleep state more effectively.

Patients underwent brain scanning using resting state fMRI to measure functional connectivity that evaluates how different parts of the brain interact with each other at the start of the study and after a month. Changes in brain connectivity reveal how the brain rewires itself when people are sleeping better. Some of the changes are related to the effects of the therapy itselfthe impact of vibration on sensory areas of the brain and some are related to the effects of improved sleep. This fMRI scan was used to determine the changes in brain function associated with auditory and vibratory stimulation in patients with insomnia. Patients also were evaluated clinically using several different measures of sleep quality and quality of life.

Compared to controls, the patients receiving the auditory and vibratory stimulation had significant changes in functional connectivity in the sensory and auditory receptive areas of the brainshowing how the stimulation seemed to be having its effect. In addition, areas involved in higher cognitive and executive functions, such as the thalamus and prefrontal cortex, were significantly affectedshowing that improved sleep improves your brains function.

This is an exciting study that shows how vibration and sound stimulation affect the brain and improve sleep in patients with insomnia and could have important implications for better managing patients with sleep problems, says corresponding author and neuro-imaging expert Andrew Newberg, MD, professor and director of research at the Department of Integrative Medicine and Nutritional Sciences. The investigators hope that this research will open up new avenues of treatment for insomnia patients.

There are no conflicts of interest. The study was funded by a gift from the Marcus Foundation.

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Vibroacoustic Therapy Shows Brain and Sleep Quality Benefits in Clinical Trial for Insomnia - Sleep Review

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"Depression Naps" Are a ThingBut Here’s What You Should Be Doing Instead – Yahoo Lifestyle

Saturday, February 8th, 2020

Anyone who has spent time on Twitter lately has likely read about #depressionnaps. People usually take these naps to escape emotions, surrender to depression, and temporarily avoid anything negative in your lifeand while the connotations are serious in theory, Twitter users have quickly escalated depression naps to meme status.

According to Daniel Amen, MD, a psychiatrist and best-selling author, depression is a common problem among women especially. He says that "20% of teen girls meet the clinical criteria for depression and 23% of women [are] taking antidepressant medication." Admittedly, it is tempting to escape our problemsbut is it the right thing to do?

If you have ever taken a depression nap, you are probably familiar with that crushing realization upon waking that your problems are still there. Depression naps can even make the problem worse. Jessica Renz, Psy.D., co-founder and licensed clinical psychologist at MindWell NYC, says that depression naps aren't the answer. They prevent you from actively participating in your life. "These naps feed the cycle of shame, blame, negative self-talk, and inaction that are major symptoms of depression," she says. Plus, they can throw off your sleep/wake cycle and makesleeping harder at night.

Here are seven healthier things you can do instead of heading for the covers when depression strikes.

It's no wonder that many experts recommend pets for seniors and have therapy pets visiting children's hospitals. Pets are healing. Studies have shown that just petting a live animal reduces anxietyany animal. Plus, animals like dogs need walkinghey, anything that will get you out the door and in the fresh air, right? If you're unable to own a pet, volunteering at your local shelter is a good way to get animal time without a long-term commitment.

SNERD Fade Journal ($22)

Grateful people are happier people. Renz suggests that you spend three minutes a day writing down at least three to five things you are grateful for. Of course, if you think of more than five things you're grateful for, don't stop there. The more, the better. Starting off (or ending) your day with gratitude will give you the framework for a better day.

Sunlight has been proven to help with seasonal affective disorder (SAD). Elizabeth Trattner, an acupuncture physician and doctor of integrative medicine, says that sunlight boosts the production of hormones that help depression and creates endorphins that make you feel better.Wearing sunscreen is still a good idea though and will protect your tender skin against sun damage.

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Tackling a big issue or dilemmamay make you want to head straight for bed, but breaking your task into smaller parts and taking one item at a time makes your goal look and feel more attainable. Plus, if youre feeling unmotivated and depressed about what you have to do, Renz says that rewarding yourself after checking off a task can be a magic bullet in breaking apart the cycle of depression.

Serving another personor even reaching out to a loved one takes the focus off you for a minute. It is easy to get absorbed in our own problems, but helping someone else with theirs can put things in perspective and give you a much-needed break from your own. Renz suggests that you stay focused on the other person in that interaction as much as possible.

Nike React Infinity Run Flyknit Running Shoe ($160)

Since the early 1900s, researchers have been interested in the connection between exercise and depression. Exercise is very effective in treating its symptoms. Researchers have concluded that what matters is how often you exercise, not how hard you exercise. Trattner, an integrative medicine doctor, says that the Chinese have been prescribing exercise for their patients for centuries as a way to move chi and make a patient feel better. She says that even a light walk will help.

If you'resleeping at night but still sleepy during the day, you might have a problem other than depression. Amen suggests that you should be checked for thyroid problems or exposure to toxins such as mold. Additionally, obstructive sleep apnea (OSA) is a serious medical condition that can cause sleepiness, depression, and can even result in death. It's estimated that 22 million Americans have OSA. A physical may help you uncover the cause of your sleepiness and what should be done to treat it.

"The bottom line is that we need to do the opposite of what depression tells us to do. Get out, get moving, and get rewarded," says Renz. It may be funny on Twitter, but frequent depression naps can be a sign that things aren't right in your life. And that's no joke.

Next up: Is It Bad to Sleep on Your Stomach? We Asked a Doctor

This post has been updated by Sarah Yang.

This article originally appeared on The Thirty

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The (over) promise of the mindfulness revolution – San Francisco Chronicle

Saturday, February 8th, 2020

The phones screen turns a serene blue, and Calm, the leading mindfulness application, opens. At the very center, without capitalization or punctuation, small and faint, are the words take a deep breath.

That gives way to a menu. What brings you to Calm?

The app offers options to reduce anxiety, develop gratitude, build self esteem, even increase happiness.

The next screen offers a seven-day free trial. Once the trial has ended, the annual rate is $69.99, a small price for happiness.

Somewhere around 2010, according to experts and Google search data, the practice of mindfulness began an upward swing. In less than a decade, it has become the fastest-growing health trend in the United States, according to the federal Centers for Disease Control and Prevention. Mindfulness rules the online app store. The San Francisco-based Calm is valued at $1 billion, and its competitor Headspace at $350 million. (The industry as a whole has been estimated to be worth as much as $4 billion.) Meditation retreats are en vogue. Corporations offer access to mindfulness in the same way they do for gyms. Even the military uses mindfulness breathing techniques to boost soldiers performance.

But as with any Next Big Thing, there are reasons to be cautious. Some say this rush into mindfulness has outpaced the science and stripped it of its cultural context. All of this threatens to turn a tool for well-being, for situating oneself in the current moment, into a tool for standard American commercialism.

Around the same time mindfulness began its upward trajectory, Ronald Purser, a management professor at San Francisco State University, started to feel the familiar weight of doubt. Hed been doing a fair amount of corporate management training and consulting redesigning the workplace to work better, at least in theory, for everybody. I became somewhat disillusioned and disenchanted, he says. Even when we were making progress, trying to redesign work so employees would have more autonomy and decision-making, the management sort of pulled the plug on some of those experiments.

It was around this time, too, that Chade-Meng Tan, a software engineer at Google, gained notoriety for integrating mindfulness into Googles corporate culture through a series of in-house mindfulness seminars. In 2012, Tan turned those courses into a blockbuster book, Search Inside Yourself: The Unexpected Path to Achieving Success, Happiness (and World Peace), and Purser found himself attending Tans very first public offering.

I became very disappointed by what I saw, just in terms of what the program was and how superficial it was, Purser says. I just saw this as part of the interest in behavioral science techniques as a way of yoking the interest or subjectivity of employees to corporate goals.

A year later, Purser published an essay with the Huffington Post. It was titled Beyond McMindfulness. Mindfulness meditation, he wrote, was making its way into schools, corporations, prisons, and government agencies including the U.S. military. Purser, a student of mindfulness for 40 years, wasnt knocking the practice but was wary of its growing reputation as a universal panacea for resolving almost every area of daily concern. Last year, Purser expanded on the essay and published a book titled McMindfulness: How Mindfulness Became the New Capitalist Spirituality.

Early on in his book, he writes this: I do not question the value of adapting mindfulness for therapeutic use, nor do I deny that it can help people. What bothers me is how its promoters want things both ways: one minute, mindfulness is science, since thats what sells; the next, it stands for everything in Buddhism, since thats what makes it sound deep.

The issues Purser called out eight years ago have only grown with time. Rhetoric, he says, still outpaces results. The practice becomes increasingly decontextualized, meme-ified and gamified. Mindfulness becomes a cure for more and more our happiness, our anxiety, our pain, even world peace.

Its worth pausing a moment to define or at least try to define mindfulness.

At its very core, its deepest and truest roots, mindfulness is a Buddhist meditation technique. There are hundreds, probably thousands of different meditative techniques. This is only one of them, says Mushim Ikeda, a Buddhist meditation teacher. Traditionally, in the Buddhist scriptures, it is said that what we call mindfulness meditation was one of 40 different techniques that the historical Buddha, the one we call the Buddha, talked about. So it wasnt even his one and only meditation technique according to those scriptures.

She knows those scriptures well. Ikeda, who primarily teaches at the East Bay Meditation Center, describes herself as a socially engaged teacher a social justice activist, author, and diversity and inclusion facilitator.

She describes mindfulness meditation as a secular term in Buddhism, one thats also called insight meditation. This is a sort of awareness, she says, that is different from the awareness that we might call everyday awareness the sort we need to drive a car, or maintain a conversation, or use an ATM. She and others describe mindful awareness as spacious and nonjudgmental. Ikeda says, Its been said mindfulness only sees. It does not judge.

The most common technique involves closing the eyes and focusing on the breath and only the breath, moving other thoughts, and the thoughts that come with those thoughts, away and out.

Mindfulness as a secular, western therapeutic intervention did not begin in Silicon Valley. Rather, youd have to go back to 1979 and a man named Jon Kabat-Zinn and the founding of the Stress Reduction Clinic at the University of Massachusetts Medical School. Kabat-Zinn has studied the effects of what he dubbed mindfulness-based stress reduction (MBSR for short), on everything from brain function to skin disease.

Still, its hard to ignore Silicon Valleys latest role in spreading and expanding mindfulness in the pursuit of a different tech culture value, peak performance. There is Search Inside Yourself, the book that coincided with the movements growth spurt. There are Twitter co-founder Jack Dorseys much-publicized meditation retreats. (Black Mirror, the dystopian science fiction show, seemed to parody both him and the now-ubiquitous apps.) Recently, there was the dopamine fast, a pseudo-scientific dopamine reset by way of doing nothing. (One originator said he drew directly from Buddhist Vipassana meditation when he crafted the fast.)

The voices are soothing and smooth soft, but not quite a whisper. The cadence and diction perfect, gently pulling you along. Birds chatter in the background. Waves move gently to meet a beach. Or maybe a brook babbles as it pushes over and under and between river rocks.

Breathing in ... I am calm.

Breathing out ... I am at peace.

A chime rings, a signal that this 90-second meditation to calm anger has ended. Calm offers its congratulations.

The danger in this rapid evolution is that it threatens to turn a very old practice into a fad that overpromises and underdelivers.

Helen Weng has practiced Buddhist meditation for more than two decades. I was reading a lot of books about psychology because I was unhappy because high school is horrible, she says. And her father, who, along with her mother, had immigrated to the United States from Taiwan, could offer her books about Buddhist philosophy. The two came together. The Dalai Lamas teachings offered her an opportunity to cultivate her own well-being. I dont like the word happiness anymore, but you can use mental exercises to become more aware of your feeling states and your thoughts.

Now Weng works as a clinical psychologist with the psychiatry department at UCSF and a neuroscientist with the Osher Center for Integrative Medicine and the Neuroscape Center, both at UCSF as well. Her scientific work uses magnetic resonance imaging to measure the amount of oxygen in the blood that flows to the brain as people meditate. Essentially, she can track whether the meditator is actually focused on their breath or if their attention has wandered. And in her clinical work, she offers meditation as one of many possible therapeutic interventions.

Still, she calls the recent spread of mindfulness very freaky.

Im very proud that practices from eastern cultures and religions generate so much interest, she says. At the same time, mindfulness and its results are super hard to study. So much so that I just thought I was a bad scientist for a long time. Whats more, she says, meditation isnt always the right sort of behavioral therapy.

Im very disturbed by these messages that meditation basically cures everything or its good for everyone or theres universally very good positive effects. The effects are really moderate and subtle. Its not any better than any other kind of psychotherapy, she says. Part of it is cultural appropriation where its this magical, mystical thing that then people can say does all these things, and I think were still in the height of that and its going to take some time for things to settle down.

Medical students, she says, inevitably ask her how much time they have to commit to mindfulness to make it work. There are studies that show clear benefits to mindfulness. Weng points to one that indicated 30 minutes a day of compassion meditation for two weeks increased altruistic giving to strangers and brain responses to pictures of people suffering.

But the key here is consistency. What happens if you work out for 30 minutes just once? she asks. It benefits you a little bit. Thats good. But if you just do it once, its not going to have a long-term effect.

After the chime and the congratulations, the waves keep moving in and out, and a quote appears onscreen. Insanity is doing the same thing over and over again expecting different results. (A quote sometimes attributed to Albert Einstein, but probably more correctly attributed to Narcotics Anonymous.) And in that moment, Calm reminds you that you really should turn on push notifications, in order to fully experience Calm. Decline and itll ask one more time about its mindfulness reminders.

Are you sure? Its hard to set aside time for yourself in our busy world without a little help.

Farrah Fawcett and Lee Majors are jogging. Theyre tan, of course. Their shorts are short. Her blond hair is fanned out, so are his brown curls. She has a broad, blindingly white smile and a red handkerchief tied around her neck. His jacket is zipped down almost to his navel; his chest is hairy. And right beside them, a headline: Farrah & Lee & Everybodys Doing It: Stars Join The Jogging Craze.

This is the cover of the July 4, 1977, issue of People magazine. Alex Will, the chief strategy officer for Calm, the industry-leading mindfulness meditation app, likes to reference this cover when he talks about mindfulness. (Theres even a copy of the issue at the office.) To understand the future of mindfulness, just look to the past.

Mindfulness is becoming mainstream, Will says. People are starting to understand that taking care of the mind is just as important as taking care of the body. Meditation and mindfulness is one way to do that.

In some respects, Calm isnt doing anything that hasnt already been done. Before smartphones, one could buy a meditation CD, slip it into a home stereo and start counting breaths. The app just makes it more portable and more accessible than ever before. I think one of the reasons Ive been so successful is that it is a very low bar for someone to try and get into, Will says. There are short, two-minute long meditations, narrations to help with sleep, even a beginners guide to mindfulness. Similarly, if you want to go deeper, we have a 30-minute master class where you can learn how to break bad habits.

All of the content, Will says, is vetted by mindfulness instructors, and, now that the app is available in more than 100 countries, the programming is also run by people to make sure translations work. This is very nuanced, he says. Language really matters. The Calm app has also been part of various clinical studies in an attempt to back up the applications rhetoric.

Mindfulness, by the way, has already had its magazine-cover moment. Not quite 37 years after the jogging craze, Time magazine featured the Mindfulness Revolution on its Feb. 3, 2014, issue. A blond, fair-skinned model stands straight, hands at her sides, eyes closed, face slightly upward. And the headline: The science of finding focus in a stressed-out multitasking culture.

Mindfulness began to trend in large part because corporations embraced the practice as a way to help employees relieve stress. This is one of the cruxes of Pursers concerns that mindfulness is just a way to wring more productivity from employees, a sleight of hand that shifts the onus from the company to the worker.

In 2012, the year Chade-Meng Tan published Search Inside Yourself, the idea of offering mindfulness courses to employees still felt novel. The New York Times featured Tan and the course hed developed for Google employees a course that involved meditation, Tibetan brass bowls, stream-of-consciousness journaling and lots of emotional openness. Even then the course was framed as a way to help employees deal with their intense workplace no mention of toning down the intensity.

Eight years later, mindfulness courses are the rule, not the exception. Apple, Nike, HBO and Target have all offered some form of mindfulness training to employees. Aetna, the insurance provider, decided to offer mindfulness and other stress-relief activities (including dog petting) after an internal study found that the most stressed-out employees spent $1,500 more a year on health care. And if a company cant bring a trained expert on board, well, they can always give employees memberships to Calm or Headspace.

The Buddha taught that almost everything comes and goes, says Muslim Ikeda, the East Bay Meditation Center instructor. Its called impermanence or change. And health trends famously come and go. Its a product of our capitalist system.

One year, its a certain kind of berry thats going to cure everything. Another year, its mindfulness meditation thats going to cure everything. Five years from now, heaven only knows, itll be something else. Burnt toast who knows?

Ikeda offers a path forward, a path separate from capitalism, a path that encourages students to cultivate a practice in which they care for themselves so that they may, in turn, care for their communities. Its an approach based in social justice and altruism. And yet, she isnt dogmatic.

Mindfulness, Ikeda says, does not judge.

A person might use mindfulness to lower their blood pressure or achieve peak performance. A corporation might use mindfulness to paper over an inherently unjust and healthy system. All this, she says, is like using a Swiss Army knife for just one thing. Its not what the tool was intended to do, and its not all it can do.

Mindfulness is always mindful awareness of something, Ikeda says. Who knows what a given individual is going to do with it? Or what it will do for them?

An individual might, for instance, become mindfully aware of a broken system.

Ryan Kost is a San Francisco Chronicle staff writer. Email: rkost@sfchronicle.com. Twitter: @RyanKost

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Continuing to work while going through cancer treatment? These tips can help – telegraphherald.com

Saturday, February 8th, 2020

The diagnosis of cancer can turn your life upside down in a matter of minutes.

It is a life-altering experience that can be a cause for a lot of stress on the individual who received the diagnosis, as well as family members and caretakers. There are many things to think about when the diagnosis is made, including whether or not youll need to continue working throughout your treatment.

Holistic therapies can aid in the reduction of stress and ease the side effects of treatment if having to work while going through cancer.

Having cancer does not necessarily mean that you will have to stop working. Most likely you will need time off for appointments, treatments or extra rest. You might decide to work as much as possible or take a leave of absence and return when you feel up to it. Or you might have to continue to work for financial reasons and/or health insurance benefits.

One benefit of working while going through cancer is that going to work can help you feel more normal.

If you decide to continue working, it could take some adjusting. Your body might respond differently to normal activities when you have cancer or are going through treatment. You might feel tired, more stressed, have pain or difficulty thinking or remembering things.

Something to consider during this trying time are the benefits of integrative health. Integrative health is the unity of conventional and holistic medicine. It is a healing-oriented model that considers the whole person body, mind, spirit and lifestyle. It uses all appropriate therapies, both conventional and alternative, and focuses on the needs, values and well-being of the person.

Here are some holistic measures to help reduce stress and side effects of treatment:

Conserve energy. Take short breaks as needed throughout your workday to keep your energy up.

Be mindful of your innermost desires and acclimate optimism into your daily thoughts. Take time for yourself to reflect, soul search and nourish the soul. A positive mental attitude during this trying time can help heal the body and reduce stress.

Consider meditation practices. Meditation clears space in your head. Apps such as Insight Timer and Headspace are great places to start.

Use reminder lists and alarms to remember your meetings or tasks. Write a list of tasks that need to be completed for the day. A daily planner, Post-it Notes or use of a smartphone might be helpful tools. Set alarms to help remind you of the tasks that need to be accomplished.

Be open and honest about your situation. Talk with your manager about any concerns. Share your feelings and concerns with your family members and health care team.

Fuel your body with good nutrition. This will help to provide optimal energy throughout the day. A dietitian with experience in oncology nutrition can help you develop a plan.

Consider using essential oils. Aromatherapy can help ease anxiety, pain and nausea symptoms. A clinical aromatherapist can help guide you on which essential oils would be beneficial.

It is important to know your rights. Side effects of cancer treatment are considered disabilities under the American Disabilities Act. Your employer must provide reasonable accommodations according to the American Society of Clinical Oncology. These can include:

Giving you breaks to take medication, see a doctor or rest.

Having you do a job that fits your new hours or abilities better.

Giving you access to counseling through an employee assistance program.

Please remember, you are not in this alone. We live in a wonderful community where people care and want to help in any way they can. Seek out services offered by the community. There are many support groups and valuable resources available to help you and your loved ones through this healing journey.

Jessica Kennedy, BSN, RN, CHC, CMSRN, Jessica is a nurse at MercyOne Dubuque Medical Center.

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UK expert calls for integration of medicine to combat cancer – The New Indian Express

Saturday, February 8th, 2020

By Express News Service

KOCHI: Time for integration has come and it is not because allopathic medicines fail in treatment but rather it is the demand of the people and patients worldwide, said Dr Michael Dixon, Chair-College of Medicine and Integrated Health, UK, and Visiting Professor, University of Westminster and University College London, while inaugurating the two-day International Conference on Integrative Oncology 2020 (ICIO 2020) at Le Meridien, here on Saturday. The conference is being organised by the Global Homeopathy Foundation (GHF).

Dr Dixon called upon integration of various medical streams while combating diseases. He pointed out that anti-microbial resistance, over-prescription of opiates (drugs derived from opium) and over-prescription of conventional medicines have compounded the situation. Enormous issues persist back in United Kingdom (UK), National Health Services (NHS) England banned herbal and homoeopathic medicines while Royal College of General Practitioners asked general practitioners not to offer Homoeopathy and National Institute for Clinical Excellence changed guidelines on palliative care and back pain, said Dr Dixon.

However, he said the good news is that at last AYUSH has arrived in UK with College of Medicine and Integrated Health taking the lead and it is also forming an Integrated Medical Alliance apart from organising a yoga conference. Integration of medical systems is of paramount importance in oncology for prevention, treatment, treating side-effects of conventional medicine and preventing recurrence, he said.Those who addressed the inaugural function included Dr Jayesh Sanghavi, vice- chairman GHF, Dr T K Harindranath, president, Indian Homoeopathic Medical Association, Dr Piyush Joshi, secretary general, Homoeopathic Medical Association of India, Dr Eswaradas, chairman, GHF, Dr Issac Mathai, Soukya Holistic Clinic, Dr Velavan, Radiation Oncologist, Erode Cancer Centre, Dr Sandeep Roy, chairman, organising committee ICIO 2020, Dr Madhavan Nambiar IAS (retd), Patron GHF and Dr Sreevals G Menon, Managing Trustee, GHF.

Over a thousand delegates from 30 countries apart from India are attending the event. Around 25 key scientific papers are being presented at the summit. ICIO 2020 is held in association with Central Health & FW Ministry, AYUSH/TCAM Ministry, all AYUSH/TCAM research councils and the governments of Kerala and Maharashtra, and National AYUSH Mission.

PRESENTATIONSDr Vinu Krishnan, member, sub-committee on cancer, Central Council for Research in Homoeopathy, New Delhi, presented a paper on Analysis and observations of stage 3 and 4 lung cancers using homoeopathic interventions while Dr K M Madhu, superintendent, Kottakkal Arya Vaidya Sala Ayurvedic Hospital and Research Centre, Kochi, presented a paper Integrative oncology-an ayurvedic approach. Dr Bindu John Pulparambil, RMO, Government Homoeo Hospital, Thiruvananthapuram, presented a paper on palliative care while Dr Ravi Doctor, associate professor with Virar Homoeopathic Medical College, Mumbai, dealt on clinical assessment of homoeopathy and its role in survival in third and fourth stage cancers. Dr Surendran Veeraiah of Cancer Institute (WIA) presented a paper on psychosocial care in oncology.

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Greens Powders Are The Secret To Getting More Veggies: Here’s How To Pick One – mindbodygreen.com

Saturday, February 8th, 2020

Even though greens powders are made of nutrient-dense foods, that doesn't mean they're a good idea for everyone. Since greens powders contain vegetables in a condensed form, they're also high in specific vitamins, like vitamin K, that can interfere with blood-clotting medications. If you're on blood thinners or other medications or you have chronic health problems, always check in with your doctor before taking a new supplement, greens powders included.

Even if you don't fall into these categories, it's important to make sure you're getting your greens powders from a trusted source. When it comes to regulation, the supplement industry is a bit of a gray area. Make sure the supplement manufacturer can verify that the greens have been tested for contamination and passed with acceptable levels. It's best to buy from companies whose greens powders have been certified through a third-party testing laboratory, like NSF International. That way, you know you're getting exactly what's listed on the label and nothing else.

And make sure you're sticking to the recommended serving size. More isn't necessarily better since some vitamins can build up in the system and lead to toxicity. A scoop or two per day, along with a healthy, vegetable-rich diet, is all you need.

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In an Industry Shaped by Decades of Decisions, Dala Wellness Seeks to Challenge the Status Quo: A Conversation With Founder Fahed Al Essa – IT…

Saturday, February 8th, 2020

SEATTLE, WA / ACCESSWIRE / February 2, 2020 / The crux of Dalas mission is to address rheumatoid arthritis (RA) from a holistic perspective. Traditionally, the US healthcare industry has sought to diagnose and prescribe as necessary. Consequently, it may be a source of global medical innovation but also is burdened with the highest costs globally that achieve mediocre to poor health outcomes.

We have grown to become a nation that is looking for quick fixes, bandaids, or a pill to solve a problem. This complements the healthcare system that addresses highly variable medical conditions with the conventional paradigm of biochemistry and medicine; we treat symptoms, not the underlying problem.

Americas health-care system focuses on curing acute problems but does far too little to support patients with chronic maladies Arthur Kleinman (WSJ article).

At Dala Wellness, founders have thoroughly researched current fixes for RA and developed their own solution via a modular program which includes a supplement, topical solution, and live community board so their members can receive support during their treatment. They are focused on the mind, body, and soul. Fahed Al Essa, founder of Dala Wellness, contributes to this conversation.

How Dala Wellness is challenging the status quo

While many self-focusing treatments leave a myriad of decisions up to the patient, Dala seeks to remove this burden and provide a gentle guide in his/her treatment. While empowering the patient is important, creating a vague, self-guided treatment can lead to decision paralysis and often results in unintended effects and/or no improvement. Dala Wellness is not this type of company. We plan to complement the patients medical journey, not replace it, Essa states.

For example, outside of pharmaceutical interventions, we employ numerous evidence-based complementary therapies that can improve a patients quality of life and ability to manage symptoms, from nutrition support and elimination diets for inflammation to mindfulness and cognitive behavioral therapy approaches that reframe pain and build resilience. This is in addition to our natural supplements.

Dala Wellness Pioneering an Industry

The short answer is: no, there are no comprehensive treatment programs like Dala that are currently in the market for RA. While the internet postulates the applications of herbal medicine to treat RA, there are no modules that combine natural medicine with mindfulness as specifically to the RA patient subset like Dala does. Dala provides a pathway for patients to combine various facets of integrative medicine to attack RA head-on.

US Expansion for Dala Wellness

The US, as a developed nation, has had notable rates of chronic condition prevalence. This has burdened the system with elevated healthcare costs, epidemics (e.g. opioid crisis in treating chronic pain), and inefficiencies in the healthcare chain. Dala is a pioneer in this realm, seeking to address life with chronic pain. As mentioned by founder Fahed Al Essa, Were supporting the health system in the US rather than adding cost to it. Were hoping to line up efficiencies in care for the patient, which then leads to cost-effectiveness within the system.

The Future of Dala Wellness

Ultimately, the future is providing access to care whatever that means. We want to make our platform affordable and accessible to any RA patient. Wherever that path leads! according to Essa.

The future is exciting. We are excited to help patients, and allow them to get back to doing the things they love doing.

Name: Tyce EscalanteCompany Name: Next Level BrandContact information: Tyce@nextlvlbrand.com

SOURCE: Next Level Brand

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Startup Incubator Aims to Spur Life-Saving Innovations – UMass Lowell

Saturday, February 8th, 2020

LOWELL, Mass. A business incubator working to improve the lives of patients with heart, lung, blood and sleep disorders is expanding its reach to the next generation of pioneering biotech and medical-device entrepreneurs.

Heart, lung and blood diseases account for 41 percent of deaths in the United States and lead to more than $400 billion in health-care expenses and lost income to patients and caregivers, according to the National Heart, Lung and Blood Institute.

Innovations supported by CAPCaT are devices and technologies well on their way to going to market. Products already being developed at CAPCaT include a product to help critically ill infants sleep better, an online education program for patients to manage hypertension and a portable device that can evaluate how the users platelets are performing. The center also seeks to support technologies that promote holistic methods of managing diseases, including devices that measure stress levels or promote mindfulness.

CAPCaT is one of four centers across the country in the National Institutes of Health Point-of-Care Technologies Research Network, which was created in 2018 to help revolutionize patient care.

M2D2s support of medical-device startups in Massachusetts has contributed $42 million in direct economic impact with a total positive effect of $75 million, according to the UMass Donahue Institute. Expanding CAPCaT is expected to increase this impact.

CAPCaT is an exciting collaboration between clinicians at UMass Medical School and engineers at UMass Lowell that helps medical-device developers as they move their products toward commercialization, knowing these life-changing inventions will help so many patients and transform the industry, said Prof. Bryan Buchholz, co-director of CAPCaT and chairman of UMass Lowells Biomedical Engineering Department.

Successful applicants will receive seed funding and the support of M2D2s medical, business and legal experts as well as those in the private sector and from the National Heart, Lung, and Blood Institute and National Center for Complementary and Integrative Health.

Last year, we received 90 expressions of interest from entrepreneurs in 26 states and three countries. We were amazed by the quality of applications we received and cant wait to see what technologies are submitted this year, said Dr. David McManus, CAPCaTs co-director and professor of medicine at UMass Medical School.

About the Massachusetts Medical Device Development Center

M2D2 operates laboratories, research and development and other workspace at UMass Lowell and UMass Medical School in Worcester for medical-device and biotech ventures. Since its inception in 2007, M2D2 has assisted more than 100 companies. Each year, the M2D2 $200K Challenge awards seed funding to the best new concepts from early-stage medical device, diagnostic and biotech companies around the globe.

About UMass Lowell

About UMass Medical School

The University of Massachusetts Medical School (UMMS), one of five campuses of the University system, comprises the School of Medicine, the Graduate School of Biomedical Sciences, the Graduate School of Nursing, a thriving research enterprise and an innovative public service initiative, Commonwealth Medicine. Its mission is to advance the health of the people of the commonwealth through pioneering education, research, public service and health care delivery with its clinical partner, UMass Memorial Health Care. In doing so, it has built a reputation as a world-class research institution and as a leader in primary care education. The Medical School attracts more than $257 million annually in research funding, placing it among the top 50 medical schools in the nation. In 2006, UMMSs Craig C. Mello, PhD, Howard Hughes Medical Institute Investigator and the Blais University Chair in Molecular Medicine, was awarded the Nobel Prize in Physiology or Medicine, along with colleague Andrew Z. Fire, PhD, of Stanford University, for their discoveries related to RNA interference (RNAi). The 2013 opening of the Albert Sherman Center ushered in a new era of biomedical research and education on campus. Designed to maximize collaboration across fields, the Sherman Center is home to scientists pursuing novel research in emerging scientific fields with the goal of translating new discoveries into innovative therapies for human diseases.

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Impact of Comorbidities and Commonly Used Drugs on Mortality in COPD – | COPD – Dove Medical Press

Saturday, February 8th, 2020

Jens Ellingsen, 1 Gunnar Johansson, 2 Kjell Larsson, 3 Karin Lisspers, 2 Andrei Malinovschi, 4 Bjrn Stllberg, 2 Marcus Thuresson, 5 Christer Janson 1

1Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden; 2Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 3Integrative Toxicology, National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 4Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden; 5Statisticon AB, Uppsala, Sweden

Correspondence: Jens EllingsenDepartment of Medical Sciences, Respiratory, Allergy and Sleep Research, Akademiska Sjukhuset, Uppsala SE-751 85, SwedenTel +46 18 611 13 93Fax +46 18 611 02 28Email jens.ellingsen@medsci.uu.se

Background: Life expectancy is significantly shorter for patients with chronic obstructive pulmonary disease (COPD) than the general population. Concurrent diseases are known to infer an increased mortality risk in those with COPD, but the effects of pharmacological treatments on survival are less established. This study aimed to examine any associations between commonly used drugs, comorbidities and mortality in Swedish real-world primary care COPD patients.Methods: Patients with physician-diagnosed COPD from a large primary care population were observed retrospectively, utilizing primary care records and mandatory Swedish national registers. The time to all-cause death was assessed in a stepwise multiple Cox proportional hazards regression model including demography, socioeconomic factors, exacerbations, comorbidities and medication.Results: During the observation period (1999 2009) 5776 (32.5%) of 17,745 included COPD patients died. Heart failure (hazard ratio [HR]: 1.88, 95% confidence interval [CI]: 1.74 2.04), stroke (HR: 1.52, 95% CI: 1.40 1.64) and myocardial infarction (HR: 1.40, 95% CI: 1.24 1.58) were associated with an increased risk of death. Use of inhaled corticosteroids (ICS; HR: 0.79, 95% CI: 0.66 0.94), beta-blockers (HR: 0.86, 95% CI: 0.76 0.97) and acetylsalicylic acid (ASA; HR: 0.87, 95% CI: 0.77 0.98) was dose-dependently associated with a decreased risk of death, whereas use of long-acting muscarinic antagonists (LAMA; HR: 1.33, 95% CI: 1.14 1.55) and N-acetylcysteine (NAC; HR: 1.26, 95% CI: 1.08 1.48) were dose-dependently associated with an increased risk of death in COPD patients.Conclusion: This large, retrospective, observational study of Swedish real-world primary care COPD patients indicates that coexisting heart failure, stroke and myocardial infarction were the strongest predictors of death, underscoring the importance of timely recognition and treatment of comorbidities. A decreased risk of death associated with the use of ICS, beta-blockers and ASA, and an increased risk associated with the use of LAMA and NAC, was also found.

Keywords: observational, LAMA, inhaled corticosteroids, beta-blockers, acetylsalicylic acid, chronic obstructive pulmonary disease

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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RMA of Connecticut Announces Doctorate Achievements for Dr. Amy Matton and Dr. Elaine Malin in the Area of Acupuncture and Chinese Medicine – PR Web

Saturday, February 8th, 2020

RMA of Connecticut Acupuncturists Dr. Amy Matton, DACM, L.Ac. and Dr. Elaine Malin, DACM, L.Ac. receive Doctorate degrees from Pacific College of Health and Science.

NORWALK, Conn. (PRWEB) February 04, 2020

RMA of Connecticut, a leading fertility practice whose exceptional quality and care helps couples and individuals grow their family, has announced that Dr. Amy Matton, DACM, L.Ac. and Dr. Elaine Malin, DACM, L.Ac., have received Doctorate degrees in acupuncture and Chinese Medicine from Pacific College of Health and Science. The doctoral degree focused on increasing clinical skills, patient-centered care, working integratively with Western medicine, and evidence-based practice. As the demand for patient-centered integrative care in the field of fertility increases, Dr. Matton and Dr. Malin will continue to provide patients with natural evidence-based care.

We want to congratulate and acknowledge Dr. Amy Matton and Dr. Elaine Malin for their achievements and dedication in the field of acupuncture and Chinese Medicine, says Robin Mangieri, CEO of RMA of Connecticut. We combine the best science has to offer through our esteemed fertility doctors along with our expansive integrative fertility and wellness programs to provide our patients with the best care all under one roof.

Acupuncture can increase fertility by lowering stress and anxiety, increasing blood flow to the reproductive organs, and balancing the endocrine system. It can also increase a couples chances of conceiving by helping to keep the normal flow of energy unblocked. RMA of Connecticut was involved in a landmark study indicating pre and post embryo transfer laser acupuncture improves embryo implantation rates by up to 15%.

Dr. Amy Matton, DACM, L.Ac. has been providing traditional and laser acupuncture to women undergoing treatment for infertility at RMA of Connecticut for 15 years. She also serves as the Coordinator for the Integrated Fertility and Wellness Programs (IFW) at RMA of Connecticut. She is a graduate of Pacific College of Health and Science with a doctoral degree in Acupuncture and Chinese Medicine, a licensed acupuncturist and certified herbalist. Dr. Mattons areas of expertise include womens health and fertility issues, pain management, anxiety, stress, and adjunctive cancer care.

Dr. Elaine M. Malin, DACM, L.Ac. is a licensed acupuncturist and certified herbalist who has worked with RMA of Connecticut patients for seven years. A general practitioner with a broad range of experience, Dr. Malin has specialized training and experience in womens health issues including fertility and pregnancy, as well as in treating anxiety, stress, and their physical manifestations.

RMA of Connecticut is a leader in integrated fertility and wellness with an emphasis on the mind, body, and spirit, which boosts overall health, improves success rates, and enhances the patient experience. To learn more, visit RMACT.com.

About RMA of ConnecticutRMA of Connecticut is a leader in fertility care, specializing in a range of infertility treatments. Our assisted reproductive technologies (ART) include intrauterine insemination (IUI), in-vitro fertilization (IVF) and pre-implantation genetic testing (PGT). RMA of Connecticut is Fairfield Countys largest fertility clinic and egg donation center. Through RMA of Connecticuts Integrated Fertility and Wellness Center, we offer nutrition counseling, individual and couples psychological counseling, acupuncture and yoga, as well as financing and support services for our patients going through infertility treatment.

Our internationally recognized Gay Parents To Be program at RMA of Connecticut specializes in LGBTQ family building. For the last three years, RMA of Connecticut has been recognized as a Leader in Healthcare Equality by the Human Rights Campaign.

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Govt hosps should try alternatives – The New Indian Express

Saturday, February 8th, 2020

Express News Service

KOCHI: While establishing Soukya Holistic Health Centre in Bengaluru, Dr Issac Mathai had a point to prove; a legitimate integration of medicines will fetch better treatment results. Recognising his methods of treatment, AYUSH Ministry selected it as a model for integrating various systems at government hospitals.Speaking at the International Conference on Integrative Oncology being held here, the doctor demanded the incorporation of alternative medicines at various oncology departments across the country.

Allopathic hospitals should incorporate alternative medicines into their cancer treatment. Though the integration of systems of medicines starts from All India Institute of Medical Sciences (AIIMS), it is not being applied in cancer-specific treatment. Government hospitals with oncology departments should include research wings with experts from alternative medicines along with patient care, he said.

The integration will help patients cut down treatment expenses, he said. When developed countries struggle to cope with the huge expense of modern medicines, India cannot move forward with a single method of treatment. Integration of alternative medicines is the only solution for the issue. While allopathy can take care of surgeries and accidents, homoeopathy, ayurveda and naturopathy can be used for chronic diseases. Therapeutic yoga will be effective in every patient, he said. He also called for better coordination from the state government to integrate the medicine systems.

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Dawn of the Customized Cure – Clinical OMICs News

Saturday, February 8th, 2020

Personalized medicine has taken a big step forward with the launch of non-profit n-Lorem Foundation, which will create patient-tailored antisense oligonucleotide (ASO) therapeutics for people with rare diseases at no cost to the patients. This comes at the same time as custom gene therapies for rare disease patients are being developed, including some combined with CRISPR. As a result, more peopleeven those with ultra-rare diseasescould finally have access to treatments.

The process of developing these treatments is still burdensome and expensive. Only a few patients will benefit at first. But this concept has only been a dream until now, with most of these patients being completely shut out of the typical drug development process. Whats more, the scientists and sponsors pioneering these approaches are hoping to create blueprints for the treatment of ultra-rare diseases in general.

One of the goals is to create a replicable protocol, said Simon Frost, the father of Annabel Frost, a child who suffers from the ultra-rare disease alternating hemiplegia of childhood (AHC). We want to do it for our disease, and then take that process and give it to more patients across many more diseases. Frost, who is CEO of Tiber Capital Group, has been in discussions with multiple labs and investigating several approaches, including ASOs, gene editing, and gene therapy.

The blueprint for the ASO-based approach was a made-to-order treatment for a child with Battens disease, a rare neurodegenerative disorder. In 2018, Timothy Yu, a doctor at Boston Childrens Hospital, sequenced the genome in then six-year-old Mila to diagnose the condition. It turned out Mila had a retrotransposon which had inserted into her CLN7 gene. That aberration was blocking normal protein production by that gene.

Yus team then created a tailor-made ASO, which they called milasen, to mask the mutation in Milas genome, as detailed last year in the New England Journal of Medicine. It took about one year from sequencing to delivery of the therapy. Then, nine months after her treatment began, Milas doctors reported being hopeful about her prognosis, although they noted that she may already have experienced substantial effects from the disease. Hundreds of people, including parents and researchers, have since reached out to Yu to try and have this process replicated. Yus lab is reportedly developing several more personalized oligos, including ones for a rare form of epilepsy and ataxia-telangiectasia, which is a neurological disease.

Addressing the challenges

The demand for more custom ASOs is intense. But there are many issues standing in the way of such therapies.

ASOs are at the point where the investment in the technology has paid off commercially, said Art Krieg, an expert in oligonucleotide therapeutics as well as founder and chief scientific officer of Checkmate Pharmaceuticals. And now Tim Yu has shown the process for making customized ASOs. The questions is whether you can standardize that and could companies find it profitable to develop those therapies. Further, ASOs only block mutations and need to be given for life.

n-Lorem is funded with $1.5 million from Ionis (formerly Isis) Pharmaceuticals, another $1.5 million from Ioniss founder and former CEO Stanley Crooke and his wife Rosanne Crooke (a researcher at Ionis), $1 million from Biogen, and additional funds from other donors. Crooke started Ionis in 1989, as a pioneer in RNA-targeted therapeutics. Today, the company has three drugs on the market and more than 30 in development for a wide range of conditions. Biogen is partnered with Ionis on several of these.

Biogen declined to comment for this article, but sent this statement: Antisense oligonucleotides have been a game changer in the treatment of spinal muscular atrophy (SMA) and we believe they could hold promise in tackling other diseases. So, we are pleased to help support the establishment of n-Lorem Foundation and their mission to provide advanced, experimental RNA-targeted medicines free of charge to patients with ultra-rare diseases.

I knew we could do this and I knew there was a need, said Crooke, who started working on n-Lorem two years ago. But he also realized it was going to be challenging. The patients need a full genomic workup, and you need an investigator who can submit the IND and oversee it, he said. One major development that convinced Crooke the concept was feasible was the 2014 establishment of the Undiagnosed Diseases Network (UDN), a research study funded by the National Institutes of Health Common Fund. The UDN comprises clinical and research experts from across the U.S. who work to solve medical mysteries. As of 2019, 12 UDN clinical sites were open.

While UDN will be a key source of qualified patients, Crooke says n-Lorem will not be restricted to those. We announced the launch last week, and we already have six proposals for patients to treat. But patients need a confirmed genetic diagnosis and treating physicians. Then they must submit a proposal to treat to n-Lorems Access to Treatment Committee.

Another critical issue is the FDAs response. Crooke said he has already approached regulators and they are supportive. But n-of-1 trials like these raise special issues. In an editorial that accompanied the Yu teams report in NEJM, FDA regulators point out the many challenges to evaluating n-of-1 drugs what are the differences between treating one, ten, or thousands of patients? they asked.

But they also acknowledge that the field is moving ahead rapidly. Academic clinicianinvestigators now have the capacity to rapidly uncover specific mutations and pinpoint the putative mechanisms leading to certain rare disease phenotypes. Various ASOs or other compounds can be produced by third parties, and investigators can evaluate them using in vitro assays or animal models, the regulators wrote. FDA is holding a workshop in March on individualized therapies to try and advance thinking around this topic.

Ioniss long experience with ASOs should help in this regard. There are several generations, or classes, of ASOs that the company has developed over the last 30 years. Many years ago I began putting together integrative safety databases about the different classes of ASOs we have developed, Crooke says. Each class has generally similar properties, but they also have important differences such has ligands that work in different organs. Ionis has published on these databases and the properties they reveal, as well as providing the FDA access to the databases. That doesnt mean, however, that researchers will be able to predict all the effects of any ASO in any patient.

Finally, there is the question of cost, which is a particular boondoggle for rare diseases. We know this is feasible but we want to reduce the costs as far as we can, Crooke says. n-Lorem and Biogen are both already working on processes to further cut costs, But we will need to raise even more money to help more patients, he added. Patients shouldnt have to be on the internet raising funds for this.

While hes aware of the challenges, Crooke said hes feeling optimistic. Ive been overwhelmingly impressed with the commitment and advice weve gotten from physicians, experts on antisense and clinical trials,and others. He also hopes more modalities, besides ASOs will be able to work with n-Lorem and start similar endeavors. Im hopeful a gene therapy company can join us or do the same thing, he noted.

Gene therapy too

While there is nothing equal to n-Lorem yet, other researchers are already pursuing customized gene therapies, even for patients who have mutations that are very rare or that are not correctable with standardized gene therapy.

Monkol Lek, for example, is a geneticist at Yale who has been working on a gene therapy for a single patient with an ultra-rare mutation in a muscular dystrophy gene. There are more than 30 types of muscular dystrophy, and some are caused by mutations that affect different genes or varying sections within those genes. Lek himself has limb-girdle muscular dystrophy (MD). When he was first diagnosed, he remembers hearing over and over again that there were no treatments for his condition.

That was enough to inspire Lek to leave a career in IT while in his 20s and obtain degrees in physiology, bioinformatics, and genetics. Soon after he arrived at Yale in 2018, Lek met Rich Horgan, founder of the non-profit Cure Rare Disease, and whose younger brother Terry has a type of MD. Lek analyzed Terrys genomic data, and found he is missing the dystrophin genes promoter region, which needs to be activated in order for that protein to be made. Terry is also missing part of exon 1, which is also necessary to generate the production of dystrophin.

While they originally considered using ASOs, Rich Horgan and Lek realized that wasnt feasible because rather than needing to turn off a gene, they needed to turn on a gene, or at least its promoter.

One twist in this particular case is that people have two alternative versions, or isoforms, of this promoter and exon 1one set in muscle cells and another in brain cells. With that in mind, Lek is using a modified version of CRISPR called no-cut CRISPR to introduce a transcription activator attached to the Cas9 enzyme to turn on the brain-specific set, and thus make up for the deficit in muscle. He uses an AAV and CRISPR activation construct as well as guide RNA to direct the CRISPR to the right spot in the DNA.

Lek has already tested his putative therapy on Terrys cells and successfully corrected the mutated gene in the lab. Next, the treatment will be tested in mice. However, Lek is also exploring the possibility of an n-of-1 clinical trial in which the therapy would only be tested in Terry or anyone with his specific mutation.

Rich Horgans Cure Rare Disease group is now leading new projects for two boys with different forms of Duchenne MD as well as a patient with the limb girdle form of the disease.

Frost, meanwhile, is still investigating the best options for treating his daughter Annabel. His family has spent $250,000 so far and he expects it will cost another $250,000 to $500,000 to reach proof of concept. Annabels mutation is in ATP1A3, a gene that is associated with at least 12 different rare diseases (See table). However, Annabels specific mutation is very rare. Were not sure yet how many of these other conditions would be treated by the same transgene, but it could be a large proportion, Frost said.

Krieg noted that we are not yet at the point where any for profit company will want to develop n-of-1 therapies. It doesnt cost that much to manufacture DNA, and its a fully automated process, he said. It has taken billions of dollars already to get the technology this far and develop applications for some more common diseases. But the overall cost of lifetime treatment is still prohibitive. Right now, I dont know why any company would want to do this, he added. But there will come a time when there are the right incentives and someone will try it.

For families such as Annabel Frosts, these developments are still encouraging, and give them hope that they can help shape the future of the new field of n-of-1 therapeutics. This also supports the idea that more children should undergo whole genome sequencing as soon after birth as possible. With many rare diseases, the damage is compounded the longer the child is untreated. Further, greater understanding of how the full range of possible mutations in any gene impact health, and how that can be treated, will press the field forward.

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Want To Be Disease-Free? This One Lifestyle Change Is All You Need! – Doctor NDTV

Saturday, February 8th, 2020

Your thoughts make up your feelings. So, the amount of time you spend on a thought, be it happy or unhappy, is going to affect your feeling and mood. Feeding unhappy thoughts can make you unhappy. Unhappiness causes discomfort, which in the long run leads to diseases.

Staying happy is important to stay stress-free and disease-free

Some of the most common diseases like obesity, diabetes, PCOD and thyroid are related to poor lifestyle. A poor lifestyle is a combination of poor eating habits, lack of exercise, smoking, drinking alcohol regularly and irresponsibly, chronic stress, anxiety and lack of sleep. According to lifestyle coach Luke Coutinho, one thing which is common in people with lifestyle is unhappiness. Unhappiness, he says, is the major cause of most lifestyle-related diseases. It is important to understand that happiness is something which you cannot seek from outside or from someone else and should come from within.

As part of a live session on Facebook, Luke says that unhappiness causes discomfort. Too much of discomfort ultimately leads to development of a disease. "Unhappiness comes from unhappy thoughts. Your thoughts are everything," says Luke.

Do not unnecessarily feed unhappy thoughts as they can make you feel stressed and uncomfortablePhoto Credit: iStock

The idea is to understand that even one happy unhappy or negative thought can make you feel uncomfortable and stressed, and ultimately affect your health negatively.

Also read:Can Stress And Anxiety Cause Hair Loss? Know Types And Ways To Hair Fall

Your thoughts make up your feelings. So, the amount of time you spend on a thought, be it happy or unhappy, is going to affect your feeling and mood.

"You are going to experience both happy and unhappy, jealous or angry, positive or negative thoughts. What matters is how much attention you pay to each of these thoughts," Luke explains.

Happiness exists independently of circumstances and conditions. As mentioned above, it comes from within and is not dependent on anything or anyone. So, a boss' feedback, an increment letter or a perfect life partner are not factors that are going to make you happy.

Happiness cannot have conditions. Conditioning it with a certain amount of money or any other kind of gain is going to make you miserable and prone to diseases.

Do not seek happiness from something or someone else. Happiness comes from withinPhoto Credit: iStock

Also read:5 Worst Inflammation Causing Foods: Avoid Them To Prevent Diseases

Thus, it is important to decide that you need to be happy by thinking of the things that are going well for you at the moment. It is important for both your physical and mental health.

Pay less attention to unhappy thoughts. Stop feeding them as unhappy thoughts lead to unhappy feelings. Do not expect your happiness from someone else. It is your responsibility and once you decide it, there is nothing that can stop you from being happy, stress-free and disease-free.

Also read:5 Lifestyle Habits That Can Help You Live Longer, Be Disease-Free

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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World Cancer Day 2020: 6 Cancer-Causing Foods And Drinks That You Need To Quit Now – NDTV News

Saturday, February 8th, 2020

World Cancer Day: Processed food, junk food and aerated drinks can increase risk of cancer

World Cancer Day is observed on February 4. Every year, the Union for International Cancer Control organises Cancer Day to raise awareness about cancer, tips for prevention and how to ease suffering for cancer patients. The theme for World Cancer 2020 is "I am and I will". World Cancer Day 2020 theme acknowledges that everyone has the capacity to act in the face of cancer. Cancer is referred to uncontrolled growth of abnormal cells in the body. Cancer develops when the body's normal control mechanism stops working. Old cells are unable to diet and they instead grow out of control, forming new and abnormal cells.

A poor lifestyle with lack of exercise, poor diet and sedentary lifestyle is one of the many reasons why more and more people are getting cancer, believes lifestyle coach Luke Coutinho. Following is a list of cancer-causing foods and drinks that you must avoid:

Research has found that the more alcohol you drink, the higher is your risk of developing cancer. Excessive alcohol intake puts you at risk of liver, breast, oesophageal and colorectal cancer. When the body metabolises alcohol, it produces acetaldehyde, which is a chemical compound that may damage DNA, leading to cancer. This World Cancer Day, pledge to limit your alcohol intake and try to get off it in full entirety. Note that no amount of alcohol (not even two drinks in a day) is healthy for your body.

Reduce your alcohol intake in order to prevent cancerPhoto Credit: iStock

Also read:Is Alcohol Consumption Linked To Heart Disease: Let's Find Out

Processed food is one of the unhealthiest foods you can include in your diet. Processed and packaged food are devoid of any nutrition. They contain high amounts of unhealthy carbs, leading to weight gain and obesity-which is a known risk factor for cancer. Processed meat like sausage, bacon, hot dogs, pepperoni and salami are even more harmful. They are made with chemical preservatives, salting and smoking to increase their shelf life. Studies have found that processed meat can increase risk of colorectal cancer. Celeb nutritionist Rujuta Diwekar says that you should avoid everything that comes in a packet, and this includes everything from soya and kale chips to tomato ketchup, condiments and dips, etc.

Switch to fresh fruits, vegetables, homemade spices and food instead of processed food to reduce your risk of cancer.

Sugary drinks like diet soda and aerated drinks are the ones that cause weight gain and provide you with zero nutrition. These drinks contain artificial sweeteners that have been found to increase risk of cancer. Instead of aerated drinks, have lemon water, coconut water, sugarcane juice or unsweetened fresh fruit juice to reduce your risk of developing cancer.

Avoid aerated drinks to reduce your risk of cancerPhoto Credit: iStock

Also read:Nmami Agarwal Decodes Health Risks Associated With Sugary Drinks: You Will Be Surprised To Know These

No matter how quick and convenient microwave popcorn are, they are doing more harm to your health than you can imagine. Microwave popcorn bag linings contain perfluorooctanoic acid (PFOA), which can be carcinogenic. The better alternative is to get fresh corn and prepare popcorn at home. It might take a few extra minutes but can reduce your risk of developing cancer.

Smoking is a lifestyle habit and is cancerous, as you all know. The top most cause of lung cancer in the world is smoking. Apart from cancer, smoking can cause coughing, breathing problems, asthma and a lot of other ailments that can affect your day-to-day functioning and reduce your lifespan. Take professional help if you are unable to quit smoking. Start with reducing one cigarette at a time. There is no tomorrow for quitting smoking.

Hydrogenated oil are commonly used for preserving processed foods and increasing their shelf life. Hydrogenated oils have the capability to alter structure and flexibility of cell membranes throughout the body, increasing your risk of cancer. Avoid foods with trans fats and saturated fats in order to reduce your cancer risk.

Along with avoiding these foods and drinks, you also need to be physically active and exercise regularly. Regular exercise can reduce your risk of cancer, high blood pressure, high cholesterol, heart disease, obesity and weight gain. This World Cancer Day, make more and more people aware of these cancerous foods, drinks and lifestyle habits and do your part in making the world cancer-free.

Also read:World Cancer Day: Follow These Expert Guidelines To Reduce The Risk Of Breast Cancer

(Luke Coutinho, Holistic Lifestyle Coach - Integrative Medicine)

(Rujuta Diwekar is a nutritionist based in Mumbai)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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