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Archive for the ‘Integrative Medicine’ Category

Playing With Fire: Should I Have Cancer Surgery? – Pain News Network

Monday, July 6th, 2020

Now my oncologists insist on doing a minor surgery to sample tissue from the tumor bed and previously effected lymph nodes. If the tissue confirms a pathological complete response, as everyone expects, Ill have a 90% plus chance of survival for the next 5-10 years. If they find any leftover cancer cells that will embed and begin to grow, well continue treatment.

I can feel those of you with CRPS grimacing. Yes, of course, I want to avoid surgery at all cost, but this is my life, and the hardest decision Ive ever had to make.

My track record with CRPS and surgery stinks to high hell. As a young woman, I was given an unnecessary LEEP procedure for cervical dysplasia, which Ive since learned usually fixes itself. As a result of that minor surgery and cauterization, my CRPS spread, and subsequently I was unable to have a baby which is one of the great tragedies of my life.

When I was 40, I was diagnosed for the first time with breast cancer and told that without surgery, chemotherapy and radiation, I had just a few months to live. I was terrified, but didnt trust western medicine anymore.

After researching my diagnosis, ductal carcinoma in situ (DCIS), and learning that these calcifications in the milk duct almost never become invasive, I chose to watch and wait. Even when my mom broke down, crying and begging, Please, Cynthia, I just want them to take the cancer out of you! -- I didnt budge for fear of a CRPS blow up. The calcifications never grew and to this day I warn women about the over care of DCIS.

About a decade ago, a physical therapist wanted to try to straighten my CRPS-contracted right arm. The therapy seemed far too risky, and I only relented when she promised to work exclusively on my head, neck and back. But she cheated and yanked, breaking my right arm. I was at a level ten pain again. It took a year to get an x-ray and correct diagnosis because I was labeled a catastrophizing patient.

The orthopedic surgeon told me that without elbow surgery Id never use my right arm again. In the end, I didnt trust the medical professionals who broke my arm to fix it. Instead, I got into my beloved YMCA swimming pool, did mirror therapy and strengthening exercises in the surrounding area and my arm slowly regained near-full function.

Fortunately, Ive forever had the gut instinct to pass on multiple recommendations for spinal cord stimulators and intra-thecal pumps, knowing the surgeries would do far more harm than good.

So here I am again, having to decide on surgery or not. But this time the stakes are much higher.

With the exception of one surgeon I know who understands CRPS because hes triggered it with breast surgeries, every western doctor is consistent. Theyre horrified by the prospect of me not doing the standard of care surgery to confirm or rule out a complete response. When the surgeon heard my plight, he responded with, Cynthia, this surgery could very well destroy your life. Damn right.

In my research to glean wisdom for this impossible decision, Ive come upon two recent, small studies. They support the protocol of post-chemo, minimally-invasive biopsy or watch and wait as an effective substitute for surgery to confirm a complete response. This may be the future for treating triple-negative cancer. But in 2020, taking this unproven route would leave me with the terrible anxiety of not knowing. Worse yet, I could suffer a quick recurrence.

What fire do I play with this go around? Do I potentially reignite my CRPS or my cancer embers? All I can do is go with my gut and heart, and call in the good karma chips from the universe Im certainly owed.

Can anyone thread the CRPS-cancer needle? I guess Im going to find out.

Cynthia Toussaint is the founder and spokesperson at For Grace, a non-profit dedicated to bettering the lives of women in pain. She has had Complex Regional Pain Syndrome (CRPS)and 15 co-morbidities for nearly four decades. Cynthia is the author of Battle for Grace: A Memoir of Pain, Redemption and Impossible Love.

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Can alternative medicine be subject to modern rigour? – The Hindu

Monday, July 6th, 2020

Patanjali Ayurvedas claimed cure for COVID-19 has been criticised for making unsubstantiated claims of efficacy. However, can ayurveda, or alternative medicine in general, be evaluated in the same way as modern medicine? Jacob Koshy discusses the question with Dr. S.P. Kalantri and Dr. Bhavana Prasher. Edited excerpts:

Dr. Prasher, could you begin by explaining what really is the process of testing a new investigational drug in ayurveda? Does it follow the phased system of clinical trials as in modern medicine?

Bhavana Prasher: There are two aspects to the use of ayurvedic drugs for clinical use. Some are those described in classical text and listed in the Drugs and Cosmetics Act of India. These have formulations that prescribe use in certain [conditions]. These are classical medicines that have been used for several hundreds of years in our country as well as in many parts of the world. If these drugs are to be used for a new condition, as we are seeing in the case of COVID-19, and there is some textual evidence to suggest that they could be useful, then they can straight away progress to human trials. We dont need studies on toxicity or pre-clinical aspects as these are already well-understood. However, if the drug is an entirely new formula, for a new set of conditions, then it has to follow the same path of toxicity, pre-clinical efficacy and subsequent clinical trials.

In a typical drug trial, an investigational drug is tested on various groups. Theres phase one, phase two... all the way up to multicentre phase three, etc. Then, it is medical statistics that decides whether the drug is actually safe and measurably improves outcomes. You also have to separate out the placebo effect. Do those same standards also apply to ayurveda?

Bhavana Prasher: For evaluating safety and efficacy, there is no difference in testing standards. But when it comes to trial design, what is an effective placebo for COVID-19? Right now, I dont think theres any medicine, or standard of care, that we can reliably compare a new drug with. However, as far as the trial design is concerned, what is more important is the outcome measures that you decide. In the context of disease management, it is not the case that one drug would work for the entire population and a single one would be useful for that patients lifetime. Drugs are evaluated based on what specific endpoint is expected. There is a very clear-cut flowchart or diagram given by the CCRS (Central Council for Research in Ayurvedic Sciences) guidelines. They say that the drug must not ignore the parameters on which it is judged by modern medicine.

Dr. Kalantri, In the case of COVID-19, several drugs are being re-purposed by pharmaceutical companies. Many times, drugs are hyped as potential antivirals, and they edge through the appraisal process by the expected outcomes being changed. We saw that in the case of remdesivir. So, dont you think that in some sense, you know, the pharmaceutical drugs, have it slightly easier, and a higher burden of proof is applied on alternative medicine?

S.P. Kalantri: Well, a science is a science is a science. I have great respect for ayurveda and its basic philosophy gels well with the Eastern approach of health and disease, in sharp contrast to the Western approach. But my point is that any drug or any intervention must figure out if the drug is safe and effective. For that, you need to follow certain rules. By merely drawing from experience in the past, quoting literature for which the drug might have worked in the past, does it mean that this drug will be as simple, as effective for a new disease? Ebola would be a great example. We thought that certain drugs worked well in Ebola and then we tried to extrapolate the results of those drugs to COVID-19, but they did not work. So often, what works in petri dishes might not work so far as actually human beings are concerned. My point is that no matter what branch you are practising, whether it is modern medicine or alternative medicine, comprising unani, siddha or homeopathy, there are certain scientific principles that absolutely must be followed. These scientific principles are basically aimed at making sure that you are minimising the bias as much as you can.

In the pharmaceutical world, normally what happens is, results of a trial are peer-reviewed and published in a journal. Independent experts can then evaluate the drugs benefits or non-efficacy. How often does that happen in alternative medicine? Are negative results reported?

Bhavana Prasher: There is a problem in that ayurvedic research publications dont appear as frequently in high-impact journals. However, I think that in general there is a paucity of negative outcomes being published and is not really a problem of ayurveda alone. Ayurvedic knowledge does not just come from experience but also relies on extensive documentation.

There are several universities and research counsellors who keep doing clinical trials that appear in ayurveda journals and thesis reports of research students. There is definitely the case that this reporting needs to be upgraded and the quality of journals improved.

Also read | Ayush Ministry lens on Baba Ramdevs COVID-19 cure

It is now well-understood that when disease reaches a certain level, you need technological interventions like, in the case of COVID-19, ventilators and pulse oximeters. However, ayurveda and other branches of alternative medicine mostly rely on natural concoctions. So, how do you integrate devices that are known to be life-saving into an ayurvedic framework?

Bhavana Prasher: They are absolutely integrated into the ayurvedic framework. I would recommend you to visit any of the modern ayurvedic institutes where the examination of the patient with respect to all these objective methods is very much adopted. There is no allergy to modern technological devices being integrated in the clinical protocols of ayurveda. Nevertheless, ayurveda also retains the methodology of assessment of disease in ayurvedic style, which is not only about focusing on the virus, but also looks at the baseline health parameters like diet and sleep. These are the immediate indicators of whether treatment is working.

Also read | Patanjali to sell Coronil as 'immunity booster,' not 'cure for COVID-19'

Dr. Kalantri, is there a way in which these two systems of medicines can be integrated? Or are they two different schools that cannot really exist under one roof but can only run parallel paths?

S.P. Kalantri: I guess an integrated approach would be a win-win situation for both disciplines because modern medicine approaches treatment from a left-brain perspective it is more rational, more analytic, more structured. Ayurveda has a holistic, more intuitive approach. It takes into consideration the person as a whole. So, while modern medicine is obsessed with a cell, or an organ, or a disease, which is a part of a body, ayurveda considers the person as a whole and believes that the whole is more important than some of the parts that it is composed of. I completely agree with this. But when we are integrating them, we should not forget the principles of science and ethics.

The way the Patanjali trial was publicised, the results were shared with the media without getting published. The most meaningful outcome we are looking at from a drug is that it should be able to save lives. A strength of modern medicine is that it looks very strongly at these endpoints (saving lives and recovery). We need to look at the large trials conducted in the last two months, the solidarity trial and the recovery trial. Both not only produced some positive results, but [the researchers] also had the humility and transparency to say that hydroxychloroquine does not work, remdesivir does not reduce mortality, the dual combination of antiviral drugs does not work.

Editorial | Science vs nonsense: On Patanjalis COVID-19 claim

Dr. Prasher, would you agree that the benefits of Patanjalis drug were hyped? And didnt it do more harm to ayurveda in the process?

Bhavana Prasher: In the case of this particular trial, I would agree that their claims were disproportionate to what was clinically proved. However, I would disagree with Dr. Kalantri in that if we are indeed looking purely at how many lives are saved, I do not know if, anywhere, ayurvedic medicine has even had a chance of [being tested] in ICUs. So, the Patanjali trial was only restricted to mild and moderate cases; all asymptomatic cases were only mildly positive, so as an endpoint, they could only test viral clearance.

There arent tests allowed anywhere where ayurveda can be tested in severe or critically ill situations which could improve outcomes. A confidence has to be built in the modern medical world as well as in society that these things can be tested in those conditions as well.

Also read | FIR against Baba Ramdev, others on COVID-19 cure claim

Ayurveda is said to be a highly personalised system of medicine. So, by definition, can treatments so customised to an individual be sold to a general population? Modern medicine, on the other hand, recommends a drug for anyone who presents a certain set of conditions.

Bhavana Prasher: Personalisation refers to the disease type or the stage of severity. If, for a given presentation, a certain drug has been useful and tested, then it can be given to others. But the clinical indication has to be very clear. However the one-drug-fits-all notion in modern medicine is itself getting challenged everyday.

Both ayurveda and modern medicine are systems of medicine. However, their products are frequently in the hands of commercial pharmaceutical companies, who deploy similar means to sell more and extol benefits over harm. So, does that undermine medicine in both systems?

S.P. Kalantri: I completely agree. In the case of a drug called Favipiravir, that has now been approved, the company charges 13,000 for a 14-day therapy for a drug that only addresses fever and cough. Most people in our country can never afford such a drug. We must, at this time, de-link this nexus between pharmaceutical companies and medicine.

Bhavana Prasher: In the desperation for a panacea, drugs that are given over the counter compromise with the principles of treatment in Ayurveda too. This does create a lot of problems and sometimes can bring more harm than benefit.

Dr. Bhavana Prasher is an ayurveda doctor and senior scientist at the CSIR-Institute of Genomics and Integrative Biology; Dr. S.P. Kalantri is a Professor at Mahatma Gandhi Institute of Medical Sciences, Wardha

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The surprising connection between well-being and living indoors – Yahoo Entertainment

Monday, July 6th, 2020

As society cautiously returns to normal, Deepak Chopra says we should reconsider the following risks: airborne (what we breathe), surface borne (what we touch) and behavioral borne (how we gather and how we care for our immune systems). (Photo: Craig Barritt/Getty Images for Something in the Water)

The lockdown that occurred in the face of COVID-19 brings to light something almost everyone overlooked in the past. We are now an indoor species. This was already true before the lockdown. Outdoor work has declined radically since the Industrial Revolution. In the West today we spend on average over 90 percent of our lives inside, whether in our homes, offices, schools, hotels or restaurants.

This development is contrary to most of human history, which was spent primarily outdoors. Unknown to most people, the boxes we now occupy have a profound impact on our health and well-being. Our physical and social environments conceivably have as much impact on our health as factors more widely recognized, such as genetics, lifestyle and behavior patterns. Indoors the elements of air and water quality, lighting, temperature and acoustics can all have a direct impact on such diverse things as respiration, sleep, immunity and cardiovascular health.

While the notion of wellness real estate first emerged several years ago, COVID-19 has brought about a sudden awareness: What surrounds us matters. What we touch matters. It makes a difference how we gather indoors and share the same air. In a word, real estate is, and will remain, the largest carrier of a pathogen load such as the coronavirus or the next pathogen we face in the future.

The risks are primarily threefold: airborne (what we breathe), surface borne (what we touch) and behavioral borne (how we gather and how we care for our immune systems).

As society cautiously returns to normal, we should reconsider all three of these risks. Programs such as the WELL Health-Safety Rating from the International WELL Building Institute (IWBI), which is evidence-based and third-party verified, focuses on strategies to protect people in a post-COVID environment. Drawing on insights from nearly 600 public health experts, virologists, government officials, academics, business leaders, architects, designers, building scientists and real estate professionals, the rating provides a reliable means to measure how effectively all building types can be maintained for the health of the people inside them.

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The rating program is relevant for all building types restaurants, schools, retail stores, offices, theatres and is a review of policies and protocols that building operators put in place regarding cleaning and maintenance requirements, emergency response readiness, social distancing, and other factors that explicitly address the risk of pathogen transmission. The WELL Building Standard expands further into design interventions such as improved air filtration and ventilation to reduce the concentration of airborne viruses, pollutants and allergens, and circadian lighting to help balance 24 hour sleep-wake cycles.

Strategies to consider based on this research include:

Enhanced cleaning products and protocols: Maintaining thorough cleaning protocols on high-touch surfaces can help reduce the chance of infection.

Improved air quality: Opening windows to increase ventilation within a space or implementing air filtration technologies can help reduce the concentration of airborne viruses, along with other pollutants and allergens.

Elements of comfort: Working from home may lead to decreased physical activity and increased strain on our bodies. Active furnishings can help discourage prolonged sitting and sedentary behaviors.

Mental health support: Connecting with nature through plants, light and access to views can help improve mood and mitigate stress. This is particular important since stress is known to weaken the immune system.

Circadian lighting design: Poor sleep quality can play a role in weakening the bodys immune function. Lighting that mimics the patterns of the sun can help promote a restful nights sleep.

These strategies are an important step in responding to todays public health challenge, but also to building a healthier future overall. One of the positive outcomes that has come to light over the past few months is a collective understanding that every facet of the indoor environment plays a role in our health outcomes. This is the next phase in promoting a holistic approach to well-being.

Paul Scialla contributed to this story.

DEEPAK CHOPRA MD, FACP, founder of The Chopra Foundation, a non-profit entity for research on well-being and humanitarianism, and Chopra Global, a modern-day health company at the intersection of science and spirituality, is a world-renowned pioneer in integrative medicine and personal transformation. Chopra is a Clinical Professor of Family Medicine and Public Health at the University of California, San Diego and serves as a senior scientist with Gallup Organization. He is the author of over 89 books translated into over forty-three languages, including numerous New York Times bestsellers. His 90th book, Metahuman: Unleashing Your Infinite Potential, unlocks the secrets to moving beyond our present limitations to access a field of infinite possibilities. TIME magazine has described Dr. Chopra as one of the top 100 heroes and icons of the century.

Paul Scialla is the Founder/CEO of Delos and Founder of the International WELL Building Institute (IWBI), which administers the WELL Building Standard globally to improve human health and wellbeing through the built environment. After 18 years on Wall Street, including 10 at Goldman Sachs as a Partner, Pauls interest in sustainability and altruistic capitalism led him to found Delos, which is merging the worlds largest asset class real estate with the worlds fastest growing industry wellness. Paul graduated from New York University with a degree in finance, and he currently resides in New York City. http://www.wellcertified.com

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Prescribing medicinal cannabis in the Northern Rivers Echonetdaily – Echonetdaily

Monday, July 6th, 2020

While this is a contentious issue across the country, many people suffering from health issues are singing the praises of medicinal cannabis.

Northern Rivers general practitioner Dr Jamie Rickcord will deliver insights into his personal experience prescribing medicinal cannabis to local residents managing chronic health conditions.

The webinar will seek to provide further information on the biological effects of taking medicinal cannabis, demystify the distinction between THC and CBD, explain how medicinal cannabis is produced and how it should be applied, as well as offer some patient case studies.

Local registered healthcare professionals are invited to attend the presentation and interact via the Q&A function.

Dr Rickcord has practiced medicine since graduating from Imperial College, London in 2006 and for the last eight years he has worked as a GP in the Northern Rivers, at ANANDA clinics in Byron Bay.

He has seen the positive effect first-hand of medicinal cannabis and is pleased with the results in his patients.

Dr Rickcord is an advocate of educating other health professionals about integrative plant medicine and is also accepting medicinal cannabis referrals for a number of conditions that have been approved for treatment by Australias Therapeutic Goods Administration (TGA).

The webinar will also feature Barb Fullerton, the national education manager of Little Green Pharma, Australias first producer and grower of medicinal cannabis.

Dr Rickcords webinarPrescribing medicinal cannabis in the Northern Rivers regionwill be held online from 6pm onTuesday, 7 July.

To register go tohttps://bit.ly/3fEjp4Nor contact Little Green Pharma.

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Like all businesses we are struggling to keep food on the table of all our local and hard working journalists, artists, sales, delivery and drudges who keep the news coming out to you both in the newspaper and online. If you can spare a few dollars a week or maybe more we would appreciate all the support you are able to give to keep the voice of independent, local journalism alive.

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Is WFH burning you out? |India Today Insight – India Today

Monday, July 6th, 2020

On May 22, Google announced a company holiday for all its employees. Why? So that they could all switch off from work for a day. Work from home burnout is a real thing and a matter of concern, for employees and employers alike. Being constantly wired and connected, working without time boundaries, feeling isolated, not being able to interact with colleagues or go for tea or coffee breaks with them, can all lead to anxiety. There is no avenue to even blow off steam post work anymore.

According to a recent survey done by Monster, more than 50 per cent of the respondents working from home due to the coronavirus pandemic are feeling burnt out. During the pre-Covid days, work-from-home (WFH) was considered to be a cool and progressive way of working. Now it has become a norm. This change in work culture had to be done overnight with a lack of preparedness, no control or choice in it. There is no doubt that WFH comes with perks like zero commute time, flexible work schedule and more bonding time with the family. However, says ontological coach and author Geeta Ramakrishnan, As the novelty of this new reality is wearing off, it is resulting in increased mental health issues, such as high anxiety, apathy, physical and mental fatigue, and a range of depression-related concerns.

Understanding the problem

Before Covid, WFH was a privilege extended by employers as a special benefit to retain certain employees. Now, things have changed. With work for home, one doesnt have well-defined boundaries between work and life, so mixing the two can become very easy, says Luke Coutinho, holistic lifestyle coach, integrative medicine.

Dr Prerna Kohli, clinical psychologist, corroborates this. She says, Previously there was a clear distinction between the workplace and home. Employees dressed in their corporate uniforms, packed their lunches, and left for work, leaving their home problems at home, and returned home at the end of the day, leaving work at work. Today, this line has been blurred. People start working in their nightwear or casual clothes and hurriedly grab lunch while working. In the fear of being laid-off, employees are working longer hours and harder during WFH and its resulting in work-life imbalance.

If this burnout is not managed, it can lead to loss of manpower hours and the workforce suffering from lifestyle diseases.

Signs of the problem

Simply put, burnout is the state of feeling depleted in terms of energyphysical and mental. So, does it have telltale signs? Quite a fewirritability, lack of patience, low tolerance level, emotional breakdowns, backaches, neck pain, lethargy, mind fog, carpel tunnel syndrome, insomnia, demotivation and reduced productivity. Take the example of Abhishek Gupta (name changed on request), an investment banker who lives alone in his penthouse in Mumbai. A workaholic and type-A personality, he has always been a go-getter and a team player at work. After the lockdown was announced on March 24, he too, like so many others, began his WFH. But, for a month now he has been feeling demotivated, stressed and irritable. On the request of his senior, he did a video consultation with his company doctor and was diagnosed with symptoms of clinical depression, as a result of work pressure and no time off. Coutinho says, WFH at times can be so bad that it could transcend into our emotional self and disturb our capacity to handle stress, which, at a time like this, is at its lowest. The lack of social contact and being confined to a small space can be intimidating. Added to the already existing string of stress is the fear and uncertainty about ones future. Will I lose my job? Will I get COVID? Will I have enough money to sustain myself?

Most often, when one has to deal with changes in lifestyle and work without giving the mind a chance to recalibrate, one tends to automatically go in survival modefight or flight. The brain is on an all-time high stress alert with your analytical and problem-solving skills at an all-time low. WFH in a pandemic is a perfect example. The high stress mode of operating becomes your new normal and this auto alert process saps your physical and mental energy causing what we now call a WFH burnout, says Ramakrishnan. Apart from getting tired fast, one gets bored and restless easily. A degree of apathy creeps in. One feels disinterested and sad for no reason and is unable to distinguish the border between work and no-work. This inability to cope can lead to frustration and irritable behaviour. You procrastinate more and your focused attention span decreases. Your hunger and need to eat either reduces or increases drastically. You manage to get some sleep but still feel sleep deprived, she adds.

Addressing the problem

Time management and self-discipline are key. Its important to have a routine similar to what you followed before the lockdown. Maintain a consistent sleep cycle, ensure adequate physical exercise, and take some time out for yourself to do the things you enjoy. Pick up a hobby such as art, music or reading, and use this opportunity to upskill. Take it one day at a time and set short-term targets to feel a sense of accomplishment, suggests Dr Samir Parikh, director and head of department of mental health and behavioural sciences, Fortis Healthcare.

Its a good idea to dress in your work attire as well, work out of a dedicated space like a desk and chair and avoid working in bed. Take regular breaks to avoid fatigue. Try to achieve a regular sleep cycle and exercise at home, practice yoga and meditation.There are various tools and techniques, like Pomodoro [a technique in which a 5-minute break is recommended after every 25 minutes of work], to help you schedule breaks in between work and use it well, says Coutinho. Use these breaks to stretch, get some fresh air, wash your face to freshen up, do eye exercises, lie down for two minutes and close your eyes. But, most importantly, value your Sundays. There is no pride in working seven days a week.

WFH may be something we have to adapt to with no choice in the matter, or it could be a temporary, but accepting it as the only way right now will help bring positivity to it. Ramakrishnan says, Defining clear boundaries is important. It could be small acts of discipline like avoiding the temptation to read office emails or taking work calls or attending webinars outside of work hours; or prioritising your work by labeling them as urgent or not-urgent.

Employers also need to play an active role in ensuring that the mental health of their employees does not suffer. They should not expect them to be available 24x7 and be productive all the time. Dr Kohli, who recently counselled a young software developer, says, He was missing the structure of working in the office and was also anxious about his parents in Lucknow. His chief complaint was that for the last few days he hadnt written a single line of code. I believe the employers must engage mental health counsellors for their staff dealing with this situation.

Going forward, the work culture will include lots of WFH as companies implement a once or twice a week only work from the office set up. In order to avoid burnout, balance your personal and professional life, and stay productive, set office hours and work only during that time.

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District Center for Integrative Medicine Center Announces Restarting of In-Person Appointments – Spin Digit

Tuesday, June 23rd, 2020

As local epidemiological trends have improved, and in consultation with experts and authorities, District Center for Integrative Medicine is excited to welcome patients back to the offices.

(Spin Digit Editorial):- Washington, D.C, Jun 17, 2020 (Issuewire.com)The District Center for Integrative Medicine (DCIM) mission has always prioritized the health and safety of our patients and staff. It is one of the few things the current situation has not changed. DCIM has designed a careful re-start strategy for in-person appointments based on that constant mission and after in-depth consultations with local and national experts and authorities, as well as a careful assessment of epidemiological trends and other data.

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People might be addressing an autoimmune condition like Hashimotos Hypothyroidism that has not responded well to typical managed care, have digestive complaints that require a highly-individualized approach, or maybe they arent sure whats wrong. Whatever health issue people are dealing with, our comprehensive approach is key to putting individuals on track to a better self.

DCIM is following all governmental guidelines and taking preventative measures to keep patients and staff safe. Listed below are some of the precautions that DCIM will be taking upon restarting in-person integrative and functional medicine appointments.

We are so excited to be able to see our patients and I am eager to work with patients in person once again, said Dr. Anjali Dsouza. In the meantime, Im still available via telemedicine for any patient that prefers it, and am excited to support their healing in any way that may be.

DCIM approaches healthcare differently. By freeing itself of the traditionally managed care constraints, including the 15-minute industry average patient appointments, DCIM sees the patient holistically. Practitioners at DCIM use the initial 90-minute appointment, for example, to understand the patients entire medical history, as well as her familys. DCIM offers advanced diagnostic testing to uncover persistent-but-often-overlooked conditions. The doctors at DCIM delve into environmental and lifestyle issues and develop individually tailored, detailed health plans. The resulting deep dive is a highly personalized analysis of the patients health.

In addition to their traditional, western medical training, the doctors at DCIM are also trained in Integrative and Functional Medicine. These disciplines treat the whole person rather than a specific disease. Because of their holistic approach, these disciplines prioritize the physician-patient relationship.

Interested in becoming a patient? Please request an appointment at https://dcimedicine.com/request-an-initial-appointment/

More about District Center for Integrative Medicine

The District Center for Integrative Medicine (DCIM), founded and directed by Dr. Anjali Dsouza, heals patients through a deeply individualized and holistic approach to health. We treat individuals with chronic complaints and conditions that persist despite the conventional managed-care model, as well as those looking to achieve the highest level of wellness. By prioritizing the patient-physician relationship, we take the time and resources to understand every aspect of your medical history, as well as nutritional and environmental factors that affect your well-being. Our role is to acknowledge your bodys innate capacity to heal and to cultivate it.

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Maryland University of Integrative Health Announces Educational Partnership with the Maryland Naturopathic Doctors Association – Reported Times

Tuesday, June 23rd, 2020

Jun 22, 2020 1:00 PM ET

iCrowd Newswire Jun 22, 2020

Laurel, Md. Maryland University of Integrative Health (MUIH) has entered a new educational partnership with the Maryland Naturopathic Doctors Association (MNDA). MUIH and MNDA share the joint goal of promoting the use of holistic and natural approaches to promote well-being for our clients. This partnership expands MUIHs role in supporting the health and wellness of Marylands residents through naturopathic medicine.

MUIHs Professional and Continuing Education (PCE) program is proud to welcome MNDA as a new partner to spotlight the field of integrative health through mission-driven collaborations. Through our evidence-based, continuing education opportunities, PCE aims to support naturopathic doctors in their professional development goals, empowering them to add to their knowledge and credentials to further support their clients and patients health and wellbeing with a whole-person approach, said Beth Romanski, director of professional and continuing education at MUIH.

In its continued effort to provide educational resources to our members, the MNDA is happy to announce a new partnership with MUIH. We will now offer MUIH PCE courses at discounts to our members so that they may continue to advance and update their knowledge in the areas of nutrition, botanical medicine, stress resilience, and general well-being, said Dr. Cristine Ehly, ND, Past President, Maryland Naturopathic Doctors Association.

Naturopathic doctors have been licensed in Maryland since 2016. MUIH is pleased to count naturopathic doctors among its faculty and to offer naturopathic medicine services in its Natural Care Center, which is open to the public. For more information about MUIH Professional and Continuing Education offerings, visit http://www.muih.edu/ce.

About Maryland University of Integrative Health (MUIH)

Maryland University of Integrative Health (MUIH) is a leading academic institution focused on the study and practice of integrative health and wellness and one of the few universities in the U.S. dedicated solely to such practices. Deeply rooted in a holistic philosophy, its model for integrative health and wellness is grounded in whole-person, relationship-centered, evidence-informed care.

Since 1974, MUIH has been a values-driven community educating practitioners and professionals to become future health and wellness leaders through transformative programs grounded in traditional wisdom and contemporary science. MUIH has more than 20 progressive graduate degree programs in a wide range of disciplines, offered on-campus and online. For more information visit http://www.muih.edu.

About Maryland Naturopathic Doctors Association (MNDA)

The Maryland Naturopathic Doctors Association (MNDA) is the professional organization of Naturopathic Doctors and the voice of Naturopathic medicine in Maryland. The MNDA is a leader in 21st-century healthcare and believes that the ability to heal resides in all of us and that conventional medicine and complementary care do not exist in opposition. The MNDA is committed to creating a greater state of health in Maryland, working with the state government to promote access to high-quality Naturopathic healthcare for all Marylanders. It is also an advocate for naturopathic doctors; offering continuing education, professional development opportunities, and professional community and support.

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Kionne S. Johnson Communications Manager [emailprotected]

Keywords:Health, Wellness, Naturopathic Medicine, Doctors, Maryland, Medicine

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Maryland University of Integrative Health Announces Educational Partnership with the Maryland Naturopathic Doctors Association - Reported Times

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Garamendi Secures Major Wins For California And The Environment In Infrastructure Bill – Patch.com

Tuesday, June 23rd, 2020

Press release from the Office of Congressman John Garamendi:

June 19, 2020

WASHINGTON, DCToday, Congressman John Garamendi (D-CA) secured key provisions to rebuild California's transportation infrastructure, increase resilience to the effects of climate change and reduce greenhouse gas emissions. The House Committee on Transportation and Infrastructure passed the "Investing in a New Vision for the Environment and Surface Transportation (INVEST) in America Act," a 5-year, nearly $500 billion investment in our nation's infrastructure and key component of the "Moving Forward" infrastructure plan unveiled by Congressional Democrats earlier this year. The bill now heads to the floor of the U.S. House of Representatives, where it is expected to pass with strong Democratic support in early July.

"We must modernize California's transportation network and address the climate crisis with infrastructure that is smarter, safer, made to last and reduces greenhouse gas emissions," said Congressman Garamendi. "The key provisions I secured in this 5-year highway bill will make our roads, bridges, and public transit more resilient to climate change and better meet our state's future transportation needs. California is the fifth largest economy in the world, and it's time that our public infrastructure looked the part. Rebuilding our nation's aging infrastructure with American workers and materials remains a top priority for me in Congress."

"California has a long and successful track record performing federal responsibilities for environmental decisions and approvals under the National Environmental Policy Act (NEPA). Through 'NEPA Assignment,' California has been able to cut the regulatory burden on thousands of transportation projects, saving months and even years in approving environmental documents. Congressman Garamendi's efforts will help us deliver transportation projects more efficiently, save the taxpayers money and speed our economic recovery from COVID-19," said Secretary David S. Kim, California State Transportation Agency (CalSTA).

The INVEST in America Act safeguards our environment and prepares our critical infrastructure to withstand the impacts of climate change by:

Congressman Garamendi, a senior member of the House Committee on Transportation and Infrastructure, secured the following key provisions in this Highway Bill (H.R.2):

This press release was produced by the Office of Congressman John Garamendi. The views expressed here are the author's own.

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MD Parents: Trying to Keep the Kids Busy and Safe During COVID-19 – Medscape

Tuesday, June 23rd, 2020

David Rosen, MD, a critical care pulmonologist based in Bergen County, NJ, arrived home from a 3-day stint in the ICU. As usual, he changed his clothes in the garage, put them in a plastic laundry bag, and, clad only in underwear, he headed straight for the guest room shower.

Earlier that day, Rose had seen five patients very sick with COVID-19, in a hospital with only four ventilators. He was devastated by the agonizing situation that had ensued. How could he force a smile and pretend everything was okay when he greeted his young children? On the other hand, he didn't want to burden or frighten them.

Rosen's 6-year-old daughter could tell something was wrong. Rosen carefully explained that Daddy was sad because there were a lot of sick people in the hospital and he couldn't help all of them.

"There's a constant balancing act between being there for patients, acknowledging my own feelings about their suffering and the horrors I've been seeing, and being there for my own family and their day-to-day emotional needs," Rosen said.

While this balancing act is part and parcel of being a physician, it has been especially wrenching during the pandemic, when the needs of family seem to be pitted against the calling to be a doctor.

Fear of infecting children has motivated some to stay in hotels, send their children to live with grandparents, self-quarantine in a separate area of the house, or avoid physical contact with the children, according to Sara "Sally" Goza, MD, president of the American Academy of Pediatrics (AAP).

"These are hard, anguishing choices, which contribute to stress and burnout," she said, emphasizing that it is a very personal decision, based on individual and family considerations, and no single solution will fit everyone.

Rosen said that staying at a hotel was not an option for him because he has a newborn baby, a 3-year-old, and a 6-year-old. "It would have been an unfair expectation for my wife to shoulder all those parenting duties without any help from me."

He added, "Of course, I'm always concerned about potential contagion and I take every precaution through rigorous decontamination procedures, but I remind myself that it's right for our family for me to be as present as possible at this time."

Ilana Friedman, MD, a pediatric ophthalmologist, starts her workday well before she leaves for the Bronx, New York-based hospital where she is the associate director of a residency program.

"I've been setting the kids up for school in the mornings, making sure they have the food they need for the day, that they're organized and ready to begin their online classes, and that their schoolwork is done," she said.

"They also text me during the day if something comes up, and I check in with them to make sure they're on task with their work," reported Friedman, whose children are 10, 11, and 13 years old.

"When I'm at work, I'm thinking about the kids at home; but when I'm at home, I think about my patients, so I never feel fully present in either place," she said.

Even when you're home, you may not have emotional or physical energy to be present for children, according to Katherine Gold, MD, MSW, associate professor of family medicine and obstetrics and gynecology at the University of Michigan in Ann Arbor.

At the end of an intensive period in the labor/delivery unit, "I can't do anything but crawl into bed, so sometimes my kids fall behind on homework and chores because I'm the person in the family who tends to make sure these things happen," Gold recounted.

Conducting telemedicine visits from home often with young children underfoot has its own challenges. Although some practices are reinstating in-person patient visits, reopening amid COVID-19 often necessitates at least a partial work-from-home schedule.

"There's no question that it's disruptive to care for small children while trying to take care of patients," said Damon Korb, MD, a developmental pediatrician based in Los Gatos, California. How to navigate this depends largely on the age of your children.

It may not be realistic to have much telemedicine time when you're the caregiver to infants or toddlers; but for preschoolers, Korb recommended "stations in different parts of the room, such as specific areas for mushy stuff, balls, books, blocks, dress-up, and eating" and "rotating the child from station to station."

He also suggested "parallel play if possible, bring your computer next to them so they can be involved with their 'work' while you're involved with yours." For the sake of patient privacy, he suggested using a headset so the patient's words remain confidential.

Although child-related interruptions during a telehealth visit may be distracting, "it might be comforting for patients to recognize that their doctors also have challenges with children at home and that we're not doing everything perfectly which they may be experiencing in their own lives," Gold said.

By the time a child is 4 or 5 years old, you can set a timer and say that when the bell rings, you'll play with them for a few minutes or reward them for their cooperation, suggested Korb, who is the director of the Center for Developing Minds and the author of Raising an Organized Child.

Maiysha Clairborne MD, an integrative medicine physician who coaches other physicians in business and entrepreneurship, said her 5-year-old son has been home from school since the end of March. His preschool held classes 3 to 4 hours per day, and "that's been a big help in keeping him occupied and up with his schoolwork." She has organized for him to be "autonomous in class" while she conducts virtual sessions and coaches colleagues.

"I check up on him between patients and clients and have lunch with him as often as I can, make sure he has virtual play dates and activities such as arts and crafts, and I try to go on walks with him around the neighborhood," reported Clairborne, who is the founder of Stress Free Mom MDand the Next Level Physicians Entrepreneur's Institute.

When your children are in front of the screen, make sure they're doing so safely, Gold cautioned, noting that there has been an increase in online sexual predators since the beginning of the pandemic. "Regularly talk to your children, including teenagers, in an age-appropriate way, tell them not trust strangers online, and monitor their activities."

Gold suggested asking an older sibling, relative, or friend toengage with the youth on social media andbe the "eyes and ears"to ensure safety online.

Summer is usually associated with camp, sports, travel, and hanging out with friends. But how many of these activities can take place this year?

Some activities will be available, according to the CDC. For example, camps are allowed to open, with specific guidelines and protocols to prevent the spread of COVID-19. Experts recommend doing your "due diligence" to find out which group activities, if any, might be appropriate for your child, taking into account your own needs as well as those of your children.

But many physicians may prefer to keep children at home rather than risk sending them into group settings.

Korb encourages parents with children of all ages to maintain a daily structure. "Get up, get dressed, don't lounge around in pajamas all day, exercise each day, and do something social and creative."

He suggested making sure that kids have "outlets," like going for walks or hikes with the family, virtual play dates, or get-togethers with friends while keeping social distancing in mind or trying a new experience, such as guitar, cooking, gardening, or learning sign language.

Talking to children about social distancing and sanitizing requirements is especially critical as they begin getting together with friends in person.

"Even very young children can understand that 'germs' cause sickness and if you get too close to other people or touch things that they touch, you can catch the sickness," AAP's Goza said.

She recounted the story of a 5-year-old patient who proudly went to the sink in her office and began washing her hands "to make sure the germs don't get to us."

Rosen's 6-year-old daughter understands the importance of not getting close to people outside the family, and even his 3-year-old understands not to touch something lying on the ground.

"It empowers kids to know that they can help themselves and others stay healthy and safe," Goza said.

Even with the most creative alternative summer plans, children of all ages are facing disappointments about missed activities, missed milestones, and uncertainty about the future.

Korb's daughter, a high school senior, missed out on her prom, graduation, and visiting the colleges she had been accepted to. She still has not made a decision about college and does not know if colleges will even be open in the fall.

"This situation is difficult for all children, but especially for adolescents, whose identity is based on the friends they hang out with and what they do with them, and many are grieving the loss of their normal lives," Korb noted.

"When people are grieving, they have to grieve," he continued. "As physicians and parents, our job is to listen, not tell them what to do, not belittle what they're saying, but support them while they find their way through the situation."

Delaney Ruston, MD, documentary filmmaker of Screenagers and Screenagers Next Chapter, which focus on solutions for healthy screen use and adolescent stress, anxiety, and depression in the digital age, agreed. "Validation is the number one skill parents should master because teens want to be understood as much as they want anything."

"Most adolescents don't have a long-term perspective on what's going on in life, so it's important to provide reassurance and place things in perspective after validating their concerns and distress," Korb advised.

Taking a "big picture" view is also helpful. "I remember my high school and college graduations, but neither have played a huge role in my life in the long run, which I have shared with my daughter," Korb said. "I'm proud that she has handled the disappointment wonderfully."

It's unknown whether schools will fully or partially reopen, and physicians may still face challenges in helping children with homework in the fall.

Korb suggested that home schooling might be different from what it was during the beginning of the pandemic. "The need for online school caught most schools off-guard, but schools will be more prepared for online teaching this time around."

He suggested turning to teachers for additional help if you're unable to provide your child with sufficient support. Additionally, "there is an entire network of online tutors popping up in response to the pandemic," he said.

Asking family friends and relatives, such as grandparents, to pitch in with helping your child with schoolwork can also go a long way toward relieving the burden that has fallen primarily on parents and it might also make schoolwork more enjoyable for the children.

Like Friedman, Michigan family medicine professor Gold feels "pulled in all directions," but has concluded that she needs to adjust her expectations.

"It's simply not feasible to be a parent, educator, emotional support system, disciplinarian, entertainer, and therapist all at once, especially during a pandemic," Gold pointed out.

"As physicians, we have high expectations of ourselves. But the most important message I can share is that none of us can possibly be as good a parent as we would like right now, so we need to recognize we're doing the best we can and give ourselves permission to fall flat sometimes," stated Gold, whose younger children are teenagers.

"At the beginning [of the pandemic] I think my kids felt they were missing out because I wasn't home while their friends' parents were," New York ophthalmologist Friedman said. "But since then, they've become proud of me. I overheard one of them say to a friend, 'My mom's a healthcare hero.' "

She added, "It's not that I feel like some kind of 'hero,' but it was validating to know that my children understand what I'm doing and why, and this helps somewhat to alleviate my guilt at being away from them so much."

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If You Want to Change, Start from the Ground Up – SFGate

Tuesday, June 23rd, 2020

By Deepak Chopra, MD and Anoop Kumar, MD

When people seek personal change in their lives, they often dont get very far. Even in this day when online advice is bewilderingly abundant and self-improvement books are at our fingertips, change eludes us. One way to remedy this is to start from the ground up. Normally, we feel compelled to start where we are right now, and thats a tremendous problem.

No matter how different people are, each of us woke up this morning to the same situation. We are constantly involved in thinking, feeling, and doing. No one starts this activity afresh. Instead, we are heavily invested in habits, beliefs, opinions, hopes, dreams, and fears collected from the past. So our thinking, feeling, and doing is entangled with the past even when we want something new, better, fresh, and different.

You cant always use will power or desire to cut the ties that bind you to the past, but you can do something that will lessen the influence of the past: You can start to see yourself clearly. With that one intention, you are starting from the ground up, because seeing yourself clearly happens here and now. You detach yourself from your story, which is the accumulation of your past. You take a fresh look at what is generating all this thinking, feeling, and doing. The process has to have an origin, a source, a wellspring that sets the active mind going every minute of the day.

Normally, if we try to see ourselves clearly, we are actually looking through a lens. We filter and arrange our experiences. Some experiences we reject, ignore, judge against, or censor. Other experiences we encourage, value, appreciate, and allow to enter our minds. The lens you choose is critical, yet people often dont realize they have a choice. It doesnt strike them in the first place that they see themselvesand everything around themthrough a lens.

The lens you see through can also be called your mindset, worldview, or simply your state of awareness. Your perspective, on life, family, relationships, work stem from it. Things become confusing because we are caught up in the conflicting stories, explanations, and belief systems that everyone gets exposed to. This confusion can be sorted out once you start to see yourself clearly. Cutting through all the clutter, you discover that you actually know whats going on. Deep inside, you are fully aware already.

There are three lenses you can view life through, configured as Mind 1, 2, or 3 at this moment.

Mind 1: You view life as a separate individual. The leading indicator of Mind 1 is the sense of localization within the body. As a result of being limited by the body, Mind 1 can only detect a world of localized things. As we see ourselves, so we see the world. You localize yourself in your body, and as a result you see a world of separate things. Other people live inside their own bodies, which gives them their own sense of separation. In Mind 1 you provide fertile ground for the ego. I, me, and mine become all-important. This makes perfect sense, because your agenda as a separate person is all about the experiences of pleasure and pain that emanate from the body. Even a mental state like anxiety is rooted in the body, because what you fear comes down to a painful feeling in here. In every respect Mind 1 is dominated by yes and no to the experiences that come your way. To achieve peace, you must successfully compete in the arena of separate people and things, experiences and events.

Mind 1 seems totally right and natural in the modern secular world. Mind 1 is reflected in sciences total focus on physical things, from microbes and subatomic particles, from the Big Bang to the multiverse. A bestselling book from 1970, Our Bodies, Ourselves, applies to all of us in Mind 1.

Mind 2: Mind 2 is centered in the unity of mind and body. It isnt necessary to see yourself confined to the physical package of a body. In fact, this mindset can be turned on its head. In place of isolation there is connection; in place of things there is process; in place of hard facts, there is an easy continuous flow. You relax into the flow of experience rather than slicing life into bits that must be judged, analyzed, accepted or rejected. Mind 2 lets you see yourself more clearly, because in reality the mind-body connection is a single continuity. Every thought and feeling creates an effect in every cell. You can consciously create change in the whole system through a switch in awareness. Mind 2 is subtler than Mind 1you have moved deeper inside who you really are, and those aspects and abilities that were filtered out by Mind 1 begin to come into view. You are the one who experiences, observes, and knows.

For most people Mind 2 begins to dawn when they meditate or do Yoga, finding access to the quiet mind that lies beneath the surface of the restless active mind. With this discovery comes a way to see beyond the separate egos fruitless search for perfect pleasure, power, or success. As a deeper vision of self and life soaks through all experience, Mind 2 is established.

Mind 3: Mind 3 expands awareness beyond all particulars. It is a radical redefining of what we mean when we use the indicator I. It places you in an infinite field of pure awareness, where all things exist as possibilities. This is not only a clear view, it is clarity itself, because there is no thing or process to obstruct your vision. Boundaries dont exist. There is no past or future. Even the idea of a present vanishes. the clearest view you can possibly have, because there are no boundaries to limit your vision. You are awake, you see things without any filter, your past no longer holds you captive, and therefore you are free, which is why Mind 3 has been known for centuries as liberation. There are no more mind-forged manacles, as the poet William Blake memorably called our self-imposed limitations.

Mind 3 is open to everyone, but there is a large obstacle that must be overcome, which is this: We are convinced by the lens we see things through already. Each mindset feels real and complete. You identify with physical things in Mind 1, the most important thing being your body. In Mind 2 you identify with your field of awareness as it brings experiences and sensations that rise and fall. Because it takes an inner journey to reach, Mind 2 isnt where the mass of humankind is, yet without a doubt anyone can go there. Mind 2 is a more natural fit than Mind 1, in fact, because if you see yourself clearly, you cannot doubt that thinking, feeling, and doing is constantly on the move, ever-changing, ever renewing itself.

But Mind 2 has its own peculiar limitation. I lingers and holds its own by experiencing my thinking, feeling, and doing. There is no need for this. Everyone alive, with the fewest exceptions, has been indoctrinated into Mind 1. In Mind 2 you escape this crude, second-hand, socially approved indoctrination. But there is a subtle indoctrination that replaces it, which sees the spiritual life as higher, better, and more valuable than ordinary life. This leads to a subtle clinging, a desire to keep the spiritual goodies coming your way and a self-image superior to those people who have not yet seen the light.

The subtle tendency to possess any idea, however fine that idea is, keeps the ego going. Letting it go entirely feels threatening. Who will I be if there is no I anymore? But if you stand back, this fearful worry only exists because the ego is asking it. Of course I will never agree to its own demotion. I is about self-preservation. The shift into Mind 3 occurs when you see that there are countless moments when you did without your ego.

Every experience of joy, love, compassion, beauty, peace, and service sets the ego aside. You go beyond I in a simple, natural glimpse of who you really are. You are the field of awareness itself, unbounded and free. Every possible experience originates here, before the whole interference of ego, society, family, school, and painful memories even begins.

Thats why Mind 3 has been dubbed the first and last freedom. It is the freedom you attain when you realize that you had it all along. Clear away the clutter, and it is simply there. Mind 1 and Mind 2 are creations, while Mind 3 is uncreated. It is the womb of creation, and when we arrive there, the inevitable feeling is that weve returned home at last. NOTE: For a visual journey through these Three Minds, visit anoopkumar.com/mind.

DEEPAK CHOPRA MD, FACP, founder of The Chopra Foundation, a non-profit entity for research on well-being and humanitarianism, and Chopra Global, a modern-day health company at the intersection of science and spirituality, is a world-renowned pioneer in integrative medicine and personal transformation. Chopra is a Clinical Professor of Family Medicine and Public Health at the University of California, San Diego and serves as a senior scientist with Gallup Organization. He is the author of over 89 books translated into over forty-three languages, including numerous New York Times bestsellers. His 90th book, Metahuman: Unleashing Your Infinite Potential, unlocks the secrets to moving beyond our present limitations to access a field of infinite possibilities. TIME magazine has described Dr. Chopra as one of the top 100 heroes and icons of the century.

Anoop Kumar, MD, MMgt is a Mind-Body Strategist who is Board-Certified in Emergency Medicine and holds a Masters degree in Management with a focus in Health Leadership. He is a keynote speaker and author who enjoys bringing clarity to the intersection of consciousness and everything else. Anoop is the author of numerous articles as well as two booksMichelangelo's Medicine and Is This a Dream? In addition to speaking and writing services, he offers consultations with individuals, teams, and organizations interested in deepening their understanding and experience of human potential, mind-body systems, and consciousness. Visit Anoop at anoopkumar.com and @dranoopkumar.

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Exosomes as Actively Targeted Nanocarriers for Cancer Therapy | IJN – Dove Medical Press

Tuesday, June 23rd, 2020

Yan Wang,1,* Yingru Zhang,1,* Gang Cai,1 Qi Li1,2

1Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, Peoples Republic of China; 2Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, Peoples Republic of China

*These authors contributed equally to this work

Correspondence: Qi Li Email qili@shutcm.edu.cn

Abstract: In recent years, it has been found that exosomes can be used as nanocarriers, which can be used in the treatment of tumors by carrying contents. The exosomes are derived from the secretion of the organisms own cells and are characterized by a phospholipid bilayer structure and a small particle size. These characteristics guarantee that the exosomes can carry a wide range of tumor drugs, deliver the drug to the cancer, and reduce or eliminate the tumor drug band. The toxic side effects were significantly eliminated; meanwhile, the therapeutic effects of the drug on the tumor were remarkably improved. This paper reviewed the strategies and drugs presented by different scholars for the treatment of tumors based on the drugs carried by exosomes.

Keywords: exosomes, nanocarriers, function, tumor therapy

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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OSU helping to drive National Institutes of Health effort to harness analytics in COVID-19 fight – The News Guard

Tuesday, June 23rd, 2020

Oregon State University is helping the National Institutes of Health to harness the power of big data in the fight against COVID-19, the disease caused by the novel coronavirus SARS-CoV-2.

The NIHs National Center for Advancing Translational Sciences is creating a centralized, secure digital enclave for collecting medical record data from COVID-19 patients throughout the United States. The enclave is part of an effort called the National COVID Cohort Collaborative, or N3C, designed to help scientists expedite their understanding of the disease and to develop treatments.

For example, can we predict who might have severe outcomes if they have COVID-19? What drugs are most likely to exacerbate or be protective against COVID-19?

Vast amounts of clinical data are being generated that can be used to push research forward, but the datasets are hard to meld in meaningful ways, said Melissa Haendel, director of OSUs Translational and Integrative Sciences Laboratory.

In the United States, there hasnt been a standardized way to collect, harmonize, securely share and reproducibly analyze all the COVID-19 data being generated, she said. N3C is overcoming these varied challenges in order to rapidly transform clinical data into useful knowledge that can improve clinical care and understand the long-term impact of COVID-19.

Haendel stressed that multiple security measures will safeguard patient privacy throughout the data collection process and that the data will not include information such as names or addresses.

The cohort collaborative is funded by the National Center for Advancing Translational Sciences and is a partnership among NCATS-supported Clinical and Translational Science Awards Program hubs and the National Center for Data to Health, or CD2H.

The N3C platform will enable machine learning approaches and rigorous statistical analyses that require large amounts of data to reveal patterns.

The N3C pulls in extensive capabilities, and by leveraging our collective data resources, unparalleled analytics expertise and medical insights from expert clinicians, we can catalyze discoveries that address this pandemic that none of us could enable alone, said Haendel, who directs the CD2H program at the Oregon Health & Science University School of Medicine.

In addition to OSU and OHSU, CD2H consists of the University of Washington, Johns Hopkins University School of Medicine, Sage Bionetworks, the Scripps Research Institute, Washington University in St. Louis, the University of Iowa, Northwestern University and the Jackson Laboratory.

The CD2H was created in 2017 by a five-year, $25 million grant from NCATS.

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Major study finds steroid reduces deaths in patients with severe Covid-19 – STAT

Tuesday, June 23rd, 2020

A cheap, readily available steroid drug reduced deaths by a third in patients hospitalized with Covid-19 in a large study, the first time a therapy has been shown to possibly improve the odds of survival with the condition in the sickest patients.

Full data from the study have not been published or subjected to scientific scrutiny. But outside experts on Tuesday immediately embraced the top-line results. The drug, dexamethasone, is widely available and is used to treat conditions including rheumatoid arthritis, asthma, and some cancers.

In a statement, Patrick Vallance, the U.K. governments chief scientific adviser, called the result tremendous news and a ground-breaking development in our fight against the disease. Scott Gottlieb, a former commissioner of the U.S. Food and Drug Administration, called it a very positive finding in an interview on CNBC. I think it needs to be validated, but it certainly suggests that this could be beneficial in this setting.

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Atul Gawande, the surgeon, writer and public health researcher, urged caution, tweeting, after all the retractions and walk backs, it is unacceptable to tout study results by press release without releasing the paper.

The study randomly assigned 2,104 patients to receive six milligrams of dexamethasone once a day, by mouth or intravenous injection. These were compared to 4,321 patients assigned to receive usual care alone.

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In patients who needed to be on a ventilator, dexamethasone reduced the death rate by 35%, meaning that doctors would prevent one death by treating eight ventilated patients. In those who needed oxygen but were not ventilated, the death rate was reduced 20%, meaning doctors would need to treat 25 patients to save one life. Both results were statistically significant.

There was no benefit in patients who didnt require any oxygen. The researchers running the study, called RECOVERY, decided to stop enrolling patients on dexamethasone on June 8 because they believed they had enough data to get a clear result.

Dexamethasone is the first drug to be shown to improve survival in COVID-19, Peter Horby, one of the lead investigators of the study and a professor in the Nuffield Department of Medicine at the University of Oxford, said in a statement. He added that the drug should now become the standard treatment for patients with Covid-19 who need oxygen. Dexamethasone is inexpensive, on the shelf, and can be used immediately to save lives worldwide.

A different arm of the same study showed on June 5 that hydroxychloroquine, widely touted as a potential Covid treatment, had no benefit in hospitalized patients. Yesterday, based in part on those results, the Food and Drug Administration revoked an Emergency Use Authorization for using hydroxychloroquine in those patients.

From the start of the pandemic in March, researchers have focused on two different stages of Covid-19, which will likely require very different interventions. Some drugs are designed to directly combat the novel coronavirus, SARS-CoV-2, that causes the disease. The first medicine shown to have a benefit, remdesivir from the biotech firm Gilead Sciences, falls into this category, even though, because it must be given intravenously, it has been tested in hospitalized patients. Remdesivir shortens the course of infection, but has not been shown to save lives.

After patients have become profoundly sick, the problem starts to become not only the virus but their own immune system, which attacks the lungs, a condition called acute respiratory distress syndrome, or ARDS. For these patients, doctors have believed, they would need to dampen patients immune response even as they fought the virus.

Initially, excitement in this area fell on new and expensive drugs, such as Actemra, a rheumatoid arthritis drug from Roche that is used to treat a similar condition caused by some cancer immunotherapies. But a study in patients who needed oxygen showed no benefit from a similar drug, although another arm in sicker patients is continuing. The National Institutes of Health is conducting a study of an Eli Lilly pill targeting rheumatoid arthritis, an extension of the study that showed remdesivir has a benefit.

Dexamethasone, which reached the market 59 years ago, seemed an unlikely candidate to help these patients; it was seen as too crude a way of tamping down the immune system. In guidelines for physicians treating the disease, the NIH doesnt even mention the therapy.

Studies that are testing other medicines may now need to incorporate the use of the drug, which could complicate analyzing the results. A spokesperson for Regeneron, which is testing Covid-19 drugs focused on both attacking the virus and dampening the immune system, said the companys studies are written so that when a new medicine becomes the standard of care, it becomes available to patients in the trial.Some studies have shown a benefit for using dexamethasone in acute respiratory distress syndrome not related to Covid-19, although the benefit was smaller than in RECOVERY.

The result, should it hold up to further scrutiny, shows the benefit of the strategy of Horby and Martin Landray, the Oxford researchers who designed the study, leveraging the U.K. health system to start a study of multiple inexpensive potential Covid-19 therapies including hydroxychloroquine, dexamethasone, and also some older HIV medicines. Several months into the Covid-19 pandemic, two of the most important results come from this single study.

Neither of those results, however, have been scrutinized or published.

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Major study finds steroid reduces deaths in patients with severe Covid-19 - STAT

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With On-Site Clinics on the Rise, Employers See Productivity and Cost Savings – Occupational Health and Safety

Tuesday, June 23rd, 2020

With On-Site Clinics on the Rise, Employers See Productivity and Cost Savings

On-site clinics are increasingly popular in workplaces, and for good reason. Not only do employees need to monitor their physical and ergonomic health, employers save money by protecting their workers.

Benefits and wellness leaders are increasingly adding on-site natural care clinics to workplaces as a way to further drive a culture of health and wellbeing among employees. Growth forecasts for worksite health offerings are bullish, with the biggest growth area being mid-sized employers (200-500 employees). As the popularity of this offering increasesand employers of all sizes, employees and health professionals work together to focus on preventionemployees experience positive health outcomes and decreased medical expenses.

Designed to reduce employee injury but also enhance employee health and increase productivity, on-site clinics have been known to bridge the gap between information and taking action in one's health, often resulting in reduced stress, improved mental, movement and physical wellbeing.

On-site clinics come in several forms and most recently include complementary and integrative healthcare such as chiropractic, educational and motivational services; balance and workstation assessment; and chair massages. Employees are empowered to engage as the provider, and offering the services has no out-of-pocket cost to them.

While the costs of risk management related to employee health and wellbeing are typically regarded as business overheads, business, operations, benefits and wellness leaders should consider the positive impacts of this long-term investment.

Reduced Healthcare Costs and Injuries

According to a recent survey, disabling workplace injuries cost U.S. companies more than $55 billion per year. Musculoskeletal conditions and poor health habits drive nearly 33 percent of these costs. Workers in construction, manufacturing, healthcare, leisure and hospitality, transportation, retail and professional and business services are at the greatest risk of these injuries. It is in these industries where the repetitive nature of the job can have a negative impact on workers physical health.

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Teens’ technology use and mental health: New report from the Connected Learning Lab provides insight into Youth Connections for Wellbeing – PR Web

Tuesday, June 23rd, 2020

We found that misplaced fears are deflecting attention from other real concerns, resulting in missed opportunities for leveraging technology and online communication to address adolescent mental health problems.

IRVINE, Calif. (PRWEB) June 23, 2020

With or without physical separation due to COVID-19, youth are using social media to connect and support each other, according to a report released today. Three leading researchers have just published Youth Connections for Wellbeing, an integrative review paper that illuminates how teens support each other through digital media during times of stress and isolation.

Leveraging their expertise across the fields of cultural anthropology, developmental psychology, and clinical psychology, scholars Mimi Ito, Candice Odgers, and Stephen Schueller discuss the potential of digital media to support youth wellbeing.

The work underlying the paper was completed prior to the COVID-19 global pandemic. The physical isolation that has resulted from shelter-in-place orders has yielded a seismic shift, making it even more critical to understand and leverage technology in a way that benefits youth.

The position paper summarizes current knowledge and redirects the conversation about adolescent social media use and wellbeing in three ways that are particularly relevant today:

1. Refocusing the debate over the relationship between youth social media use and wellbeing to reflect existing evidence, varied youth perspectives and backgrounds.

2. Identifying teen vulnerabilities and assets that may influence problematic and healthy social media engagement.

3. Suggesting opportunities where youth social engagement might mitigate vulnerabilities and leverage assets.

In the position paper Ito, Odgers, and Schueller highlight the need to move beyond the simple question of whether more time spent using social media causes mental health problems in adolescents. Instead, people should consider the specific forms of social media engagement that amplify or mitigate mental health risks for different adolescents. The team integrates findings from existing large-scale reviews, the voices of youth who have grown up on social media, and a systematic review of digital mental health apps available for youth.

The team finds that adolescents online risks often mirror offline vulnerabilities. They note that it is particularly important for messages, interventions, and strategies to be targeted and tailored to the most vulnerable youth and those underserved by traditional mental health services.

A number of relevant findings, opportunities, and benefits are outlined in the paper, including:

For example, one student interviewed shared how they experienced a supportive community online, saying: I think a lot of my mutuals on Instagram, they're very open to being emotionally vulnerable on Instagram, so they'll actually say, I'm not doing fine. I like it because it's a very nice community, just spreading love whether it be through comments or someone will actually say through messages like, Are you okay?

A freshman adjusting to life away from family shared how online connections made her feel close to them: My mother just started using Messenger. I taught her how to use it. And so she texts me here and there. She's like, Good morning, or, How are you doing?, and then we FaceTime. Then my siblings, we use Instagram because that's where we're mostly at. We send each other videos and memes, and then we kind of comment just to make our day.

Given the rising rates of mental health concerns among young people in the U.S., Ito, Odgers, and Schueller encourage a sense of urgency in focusing research, investment, and public attention on how digital spaces and tools can be better designed and used to support youth's mental health.

The paper, which was supported by Pivotal Ventures (https://www.pivotalventures.org/), a Melinda Gates Company, was published by the Connected Learning Lab at the University of California, Irvine, and is available at https://youthwellbeing.online/ReportRelease.

About the Authors

Mimi Ito is a learning scientist and a cultural anthropologist of technology use, examining children and youths changing relationships to media and communications. She is Director of the Connected Learning Lab, Professor in Residence and John D. and Catherine T. MacArthur Foundation Chair in Digital Media and Learning at the University of California, Irvine.

Candice Odgers is a developmental psychologist who studies adolescent mental health and how digital technologies can be leveraged to understand and support wellbeing. She is the Co-Director of the Child and Brain Development Program at the Canadian Institute for Advanced Research, a Professor of Psychological Science at University of California, Irvine, and a Research Professor at Duke University.

Stephen Schueller is a clinical psychologist and mental health service researcher who focuses on using technology to expand access to and improve the accessibility of mental health services. He is an Assistant Professor of Psychological Science at the University of California, Irvine, and an Adjunct Assistant Professor of Preventive Medicine at Northwestern University, Feinberg School of Medicine.

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines – Hindustan Times

Tuesday, June 23rd, 2020

More than 8.4 million people have contracted the coronavirus disease (Covid-19) and 453,290 have died across the world in nearly six months after it was first reported from Chinas Wuhan late last year.

Around 10 potential vaccines are now undergoing trials in humans, in the hope that a shot to prevent infection can become available in coming months. And even before any vaccines have been proven to work, several countries have already begun making deals with pharmaceutical companies to order doses.

The World Health Organization (WHO) hopes hundreds of millions of doses of coronavirus vaccine can be produced this year and 2 billion doses by the end of 2021, chief scientist Soumya Swaminathan said on Thursday.

The WHO is drawing up plans to help decide who should get the first doses once a vaccine is approved, she said.

Priority would be given to frontline workers such as medics, those who are vulnerable because of age or other illness, and those who work or live in high-transmission settings such as prisons and care homes.

Here are all the latest updates you need to know about Covid-19 vaccines:

Caution on dexamethasone

Dexamethasone, a cheap steroid that can help save the lives of patients with severe Covid-19, should be reserved for serious cases in which it has been shown to provide benefits, the World Health Organization (WHO) has warned.

Mike Ryan, the head of the WHOs emergencies programme, said the drug should only be used in those serious cases where it has been shown to help.

It is exceptionally important in this case, that the drug is reserved for use in severely ill and critical patients who can benefit from this drug clearly, Ryan said during a briefing.

Trial results announced on Tuesday by researchers in Britain showed dexamethasone, a generic drug used since the 1960s to reduce inflammation in diseases such as arthritis, cut death rates by around a third among the most severely ill coronavirus patients admitted to hospital.

The research body involved in the trial was the same one which found evidence that HCQ (Hydroxychloroquine) was not extremely effective on all Covid-19 patients.

That makes it the first drug proved to save lives in fighting the disease. However, some doctors were cautious, citing possible side-effects and asking to see more data.

Volunteers lining up to be infected

Thousands are signing up to take part in a high-stakes experiment willing to deliberately expose themselves to the coronavirus to test a potential vaccine, should researchers decide to proceed.

Known as human-challenge studies, these tests can hasten research by placing volunteers in the path of the virus, rather than waiting for accidental exposure.

Pascal Soriot, chief executive officer of drugmaker AstraZeneca Plc, said the controversial approach may become necessary at some point as the disease ebbs in some cities, making it harder to evaluate shots in the more conventional way.

The company is working with the University of Oxford on one of the most advanced vaccines against the virus.

The initiative is organized by 1DaySooner, a group that advocates on behalf of people who want to join challenge studies. The organisation has held discussions with potential partners and vaccine manufacturers in a bid to start production of the virus, said Josh Morrison, one of its founders.

More than a quarter of the volunteers are in Brazil, where the coronavirus is spreading fast.

Morrison said 1DaySooner has contacted vaccine developers planning final-stage studies there to suggest they consider people on its list for conventional studies, too.

Proponents note that the approach was used safely for diseases such as malaria, typhoid, cholera as well as the flu. Some experts are calling for a cautious approach.

Caution towards polio vaccine for Covid-19

Indian scientists have responded cautiously to a suggestion by global researchers that the oral polio vaccine be tested for Covid-19 treatment, saying it is a testable idea based on a sound scientific concept but may offer only limited protection against the infection.

With a vaccine for Covid-19 at least a year away, scientists say repurposing already safe and effective vaccines is the way to go for immediate relief against Covid-19.

The repurposed vaccines could include the oral polio vaccine (OPV) and the Bacillus CalmetteGuerin (BCG) used against tuberculosis, both part of the immunisation given to Indian children.

It is worth conducting a clinical trial, said Ram Vishwakarma, director of the CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM) in Jammu.

A study was published last week by an international team of researchers in the journal Science. The researchers, including Shyamasundaran Kottili and Robert Gallo from the University of Maryland School of Medicine in the US, said the OPV should be tested to see if it might protect people from the SARS-CoV-2 virus.

They noted that the vaccine used to prevent poliomyelitis infections has been around since the 1950s, and is found to provide some protection against other viral infections.

Hydroxychloroquine wont stop coronavirus deaths

WHOs top scientist has said its now been definitively proven that the cheap malaria drug hydroxychloroquine the drug favoured by President Donald Trump doesnt work in stopping deaths among people hospitalised with the new coronavirus.

But Dr Soumya Swaminathan said there could still be a role for the drug in preventing people from catching Covid-19 in the first place and noted that clinical trials testing hydroxychloroquines role in this are ongoing.

Swaminathan said in a press briefing on Thursday that there is still a gap in determining whether hydroxychloroquine has a role at all in the prevention or minimising the severity of the illness in early infection or even in preventing it.

The UN health agency announced this week that it is suspending the hydroxychloroquine arm of its own trial testing various experimental therapies for Covid-19, referring to previous results from a large UK trial and a separate analysis of the evidence on the drug.

The other drugs being tested by WHO, including treatments used in the past for Ebola and AIDS, are still being pursued.

(With agency inputs)

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From warning on dexamethasone to HCQ: Latest on Covid-19 treatment, vaccines - Hindustan Times

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Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer – GlobeNewswire

Tuesday, June 23rd, 2020

Achilles Therapeutics doses first patient in Phase I/II Study in advanced non-small cell lung cancer

Stevenage, UK 23 June 2020 Achilles Therapeutics (Achilles), a clinical stage biopharmaceutical company developing personalised cancer immunotherapies, today announced that it has dosed the first patient in a Phase I/II CHIRON study of a clonal neoantigen T cell (cNeT) therapy in patients with advanced non-small cell lung cancer (NSCLC). In May 2020, Achilles dosed the first patient with cNeT in its Phase I/II THETIS study in recurrent or metastatic malignant melanoma.

Achilles precision tumour-infiltrating lymphocyte (TIL) therapy uses cutting edge genomics to selectively target patient specific clonal neoantigens targets which are believed to be present on all tumour cells this approach has the potential to transform the treatment of cancer.

The CHIRON study is an open-label, multi-centre Phase I/II trial evaluating the safety, tolerability and clinical activity of cNeT therapy as a single dose in adult patients with advanced metastatic NSCLC. The trial is expected to recruit approximately 40 patients and report interim data in the first half of 2021. Recruitment is ongoing across sites in the UK, with additional sites to open in the US and Europe. Link to Study.

The cNeT dosing of the first patient with NSCLC marks another important milestone for Achilles. Our opportunity to serve patients is tremendous as NSCLC remains one of the most prevalent and poorly served of the solid tumours, said Dr Iraj Ali, CEO of Achilles Therapeutics. As with our melanoma study, the CHIRON study is an entirely personalised cell therapy designed to be exquisitely specific and effective and has the potential to help us fundamentally change how certain cancers are treated.

We have been working closely with the Achilles team to design and set up this study across the UK, and are delighted to be dosing the first NSCLC patient with this innovative experimental cell therapy here at University College London Hospital (UCLH), the lead clinical site, said Dr Martin Forster, Associate Professor in Medical Oncology and Study Chief Investigator.

Achilles is developing personalised T cell therapies for solid tumours targeting clonal neoantigens: protein markers unique to each patient that are present on the surface of all cancer cells. Using its PELEUS bioinformatics platform, Achilles can identify clonal neoantigens from each patients unique tumour profile which are present on every cancer cell. Achilles uses its proprietary process to manufacture T cells (cNeT) which exquisitely target a specific set of clonal neoantigens in each patient. Targeting multiple clonal neoantigens that are present on all cancer cells, but not on healthy cells, reduces the risk that new mutations can induce immune evasion and therapeutic resistance, and allows individualised treatments to target and destroy tumours without harming healthy tissue.

- Ends -

Notes for Editors:

About Achilles Therapeutics

Achilles Therapeutics is a clinical stage, biopharmaceutical company developing personalised T cell therapies targeting clonal neoantigens: protein markers unique to the individual that are expressed on the surface of every cancer cell. The Company has two ongoing Phase I/II studies, the THETIS study in patients with recurrent or metastatic malignant melanoma and the CHIRON study in patients with advanced non-small cell lung cancer (NSCLC). Achilles uses DNA sequencing data from each patient, together with the proprietary PELEUS bioinformatics platform, to identify clonal neoantigens specific to that patient, and then develop personalised T cell-based therapies specifically targeting those clonal neoantigens.Achilles was founded in 2016 by lead investor Syncona Ltd and in September 2019 the Company raised 100M in an oversubscribed Series B financing led by RA Capital, cornerstoned by Syncona and joined by new investors including Forbion, Invus, Perceptive Advisors and Redmile Group. For further information please visit the Companys website at:www.achillestx.com

About Lung CancerLung cancer, which forms in the tissues of the lungs, usually within cells lining the air passages, is the leading cause of cancer death worldwide. Each year, more people die of lung cancer than die of colon, breast and prostate cancers combined. The two main types of lung cancer are non-small cell and small cell. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for about 85% of all cases. The five-year survival rate for patients diagnosed in the United States with any stage of lung cancer is estimated to be 18%.

About TRACERxThe TRACERx (TRAcking Cancer Evolution through therapy (Rx)) is a translational research study, led by Achilles founder, Professor Charles Swanton, aimed at transforming our understanding of cancer evolution and take a practical step towards an era of precision medicine.

Despite major advances in the understanding of cancer biology and the translation of these findings into novel therapeutics, the majority of patients with advanced melanoma fail to derive durable clinical benefit from existing standard-of-care therapies. Through integrative analysis of genomic and immunological landscapes, the TRACERx study seeks to address this. Tumour specimens and peripheral blood are studied in highly relevant contexts at multiple stages of a patients treatment journey, from potentially curative resections of locally-advanced disease, through to biopsies of lesions responding or refractory to systemic therapies in the setting of advanced disease.

Wherever possible, analyses will be performed in a longitudinal manner, allowing serial assessment of anti-tumour immunity, tumour-specific genomics and their interaction. Key objectives of the study include determination of spatial and temporal changes in immunological, genomic and transcriptomic landscapes, identification of novel molecular drivers, immunotherapeutic targets and assessment of the impact of cytotoxic, immune-modulatory and targeted therapies on both the tumour microenvironment and peripheral blood.

Further information:

Achilles TherapeuticsDr Iraj Ali Chief Executive Officer+44 (0)1438 906 906media@achillestx.com

Julia Wilson Head of Communications+44 (0)7818 430877j.wilson@achillestx.com

Consilium Strategic CommunicationsMary-Jane Elliott, Sukaina Virji, Melissa Gardiner+44 (0) 203 709 5000achillestx@consilium-comms.com

US Investor Relations - Solebury Trout Lee Stern +1 646-378-2922 lstern@troutgroup.com

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Why a wellness routine is your top priority amid the pandemic and how to start – KSL.com

Tuesday, June 23rd, 2020

NEW YORK (CNN) As states gradually reopen even as the pandemic wears on, many of us are concerned about our health and well-being. Especially now, with some continuing to stay at home and social distance while others join the throngs at nationwide Black Lives Matter protests, it may even be a priority.

From state to state, the loosening of restrictions vary, and within our local communities, the reality is that not only do people have different ideas on what constitutes social distancing but for many others still, in the face of racial inequality, the desire to create social change far outweighs the potential risk of spreading or catching the virus.

It's all the more reason to make sure we're taking the best care of ourselves to fortify against the disease. But while living a healthy life may be a desired goal, how to achieve it is another story.

Even if you're someone whose healthful habits were perfected to a tee during pre-pandemic times, you may find yourself struggling to engage in even the most basic self-care in these increasingly unpredictable days.

That's where a wellness routine can come in handy.

I'm not talking about a spa escape every so often or even regular massages or chef-prepared meals (though all of that may sound really nice). I'm talking about creating your own personalized routine that will benefit you physically and emotionally, one that simply requires a regular commitment to yourself.

Creating a wellness routine allows you to shift from diet culture and adopt healthy habits that easily fit into your daily lifestyle. What's more, having a routine allows you to focus on health goals by creating structure and organization, which can be particularly beneficial when things seem out of your control, like life during an unprecedented pandemic and simultaneous upheaval as people fight against social injustice.

In fact, predictable routines, or ritualistic behavior "developed as a way to induce calm and manage stress caused by unpredictability and uncontrollability, heightening our belief that we are in control of a situation that is otherwise out of our hands," according to researchers at Tel Aviv University.

"We need an internal structure because our external lives have become totally unstructured and that triggers anxiety and stress," said Robin Foroutan, a New York City-based integrative medicine dietitian and spokesperson for the Academy of Nutrition and Dietetics.

"In the beginning, we thought this was going to be a little break; a couple of short weeks, and then we'd resume life as we knew it. Now we know that probably is not going to be the case. We don't know how long this will last, but we can find ways to stay steady and structured on the inside amidst the chaos outside."

Engaging in a wellness routine with a focus on good nutrition, exercise, sleep and stress management can boost our health and well-being and strengthen our immunity during a time when we may need it most.

And while social obligations, travel and other commitments typically make it challenging to start new habits, being stuck at home without these distractions provides an opportune time to start creating a wellness routine that is accessible, doesn't require a lot of money and is something that you can count on during this uncertain time and in the future, too.

Health experts say it's important to create a manageable routine that you can stick with as part of a lifestyle not something overly ambitious that you can't sustain. One way to do that is to start small and build upon it, as you feel comfortable.

Here are some tips to get started in creating your personal wellness routine.

"Most people feel better when they are going to bed and waking up at consistent times, eating regular meals and snacks and getting a steady dose of exercise, said Marysa Cardwell, a registered dietitian, nutrition therapist and certified personal trainer based in Salt Lake City, Utah.

For sleep: Everyone's sleep schedule is different, and that's OK, as long as you stick to your natural circadian rhythms, experts say. That means going to sleep when the sun is setting (or a bit later) and waking up when sun is rising (or a little later, according to your individual needs).

Aiming for seven to nine hours of sleep is key, as it helps to "reduce the stress hormone cortisol and your adrenal load," Cardwell said.

Getting adequate sleep also bodes well for engaging in other healthful behaviors by going to bed at a reasonable hour, you'll be less likely to engage in nighttime eating or mindless eating in front of the TV, and you're more likely to wake up early and start exercise, Cardwell explained.

For eating: Setting regular meal times, and taking a break to eat your food mindfully is key, Cardwell advised, but when you actually eat is up to you. "Some do well on three meals per day with an afternoon snack; others prefer three smaller meals and three snacks."

Regardless of the pattern you choose, aim to eat at least every four hours, which prevents blood sugar from crashing and can lead to overeating. For example, if you're eating three meals and one afternoon snack, you might choose to eat breakfast at 8 a.m., lunch at 12 p.m., a snack at 4 p.m. and dinner at 7 p.m.

Taking a few deep breaths, enjoying the wonderful smells of the food you are about to eat and chewing food really well can all help make mealtime a healthful ritual, Foroutan explained.

Additionally, dinnertime can become a daily social ritual by sharing the meal with family or friends, advised Jen Scheinman, a Denver-based registered dietitian nutritionist and owner of Jen Scheinman Nutrition, a virtual nutrition coaching practice. "Even a Zoom dinner with a friend if you're by yourself can help you feel connected."

For fitness: Pick a time that you're most likely to stick with. That might mean taking a morning walk before your day gets started, or scheduling your favorite fitness class on your calendar so you won't forget.

"I shut my day down with a run or yoga at around 5:30 p.m. That's my last thing for the day. The more you can make it a routine, the less you have to think about it," Scheinman said.

Planning what you will eat and how you will exercise means that you are more likely going to do what you intend to do, which will ultimately help you achieve your health goals. For example, planning meals in advance means you'll be less likely to reach for quick sugary snacks when you run out of energy. It also helps to limit shopping trips.

"Not only does planning your meals ahead of time help cut down on the number of times you're going to the grocery store, but it can also help reduce food waste and ensure you have meals that were intentionally picked to fit your nutritional goals," said Denver-based registered dietitian nutritionist Kelli McGrane.

For food: Eating a nutrient-rich breakfast sets the stage for making other healthful choices throughout the day.

Choose protein-rich breakfasts like egg whites, cottage cheese or smoked salmon on a bagel; Greek yogurt, smoothies with low-fat milk, high fiber cereals with milk or peanut butter on whole wheat toast.

Scheinman recommended preparing breakfast foods ahead of time, like making overnight oats with milk. "It makes the breakfast routine less daunting."

For lunch and dinner, Cardwell encouraged a fist-size portion of protein, such as fish, chicken or beans; a fistful of carbohydrates like whole wheat pasta or brown rice; and a half plate of veggies. This will help meet your micronutrient needs, as well as fiber. Use fats sparingly, as a condiment, to make your food taste better, but limit fried foods and saturated fat, Cardwell advised.

For snacks, choose protein and carb combos, like cheese with crackers, sliced fruit with peanut butter, nuts and seeds with dried fruit or Greek yogurt. Pairing protein with carbs "helps keep your blood sugar level stable, and helps you stay fuller longer," Cardwell said.

Scheinman recommended using the weekends for batch cooking, like making chili or soups, which you can freeze to enjoy later in the week. Washing and chopping veggies and fruit during the weekend can also save you time during the week.

For fitness: Pick a fitness activity that inspires you and is doable. There are a lot of fitness apps offering free trials and online Zoom fitness classes, so you can use this time as an opportunity to try something new. Cardwell recommended aiming for at least 30 minutes per day, if possible.

If you are looking for a simple at-home cardio workout, MaryAnn Browning, founder and CEO of Browningsfitness in New York, recommended jumping jacks, high knees, butt kicks, burpees and switch jumps during which you'll jump to turn 180 degrees and then back again for 15 seconds each. Then repeat the circuit five to 10 times, depending on what you can handle.

For at-home fitness essentials, Browning recommended getting a set of yellow, green and red resistance bands, which can be used for back, bicep, triceps, shoulders and leg work. She also recommended looped bands to go around the calves or thighs, which strengthen the glutes and can help prevent knee and back injuries.

If you want to weight train but don't have equipment, anything that will give you muscle tension will be beneficial, such as jugs of water, books or even your children. "I use my kids I'll do planks and have them sit on me ... or I'll do leg presses while letting them do airplane," Cardwell said.

And don't forget to keep moving throughout your day. Tracking apps like Lose It! are a good way to see how normal daily activities can all count toward our daily fitness goals.

"Dancing with your kids or partner, yard work, house projects, sex and cleaning are all trackable activities. Doing these activities with intention and extra vigor all count towards a healthy lifestyle," said Cardwell, who is also a contributing dietitian for Lose It!

For sleep: Engage in a bedtime routine where you can quiet down and prepare for sleep. "Turn off electronics, including the TV, iPad, and cell phones an hour before bedtime," Scheinman advised. This helps to reduce exposure to blue light, which "the brain perceives as daylight, so your brain is not quite getting the signal that it's nighttime and melatonin is not produced."

Unplugging also prevents you from checking one more email or scrolling through social media while in bed, which can be stimulating and interfere with sleep, Scheinman explained.

Most experts recommended engaging in a morning ritual that brings you pleasure. "Starting your day with the same routine each morning can bring steadiness and calm to the rest of the day. You are starting from a more grounded and positive place, versus waking up; grabbing the phone and checking the news and getting stressed out," Foroutan said.

"The morning is a nice time to start integrating things you didn't have time for previously like taking the dog for a longer walk in the morning, making a nice cup of coffee you can sit and enjoy or engaging in a meditation practice," Scheinman added.

"It sets the day off with a healthy intention, with a sense of comfort. ... I know this is what I do," Scheinman said.

Foroutan enjoys waking up and writing down three things she is grateful for. "Starting the day with a thought about gratitude can be really centering. Writing it down does something extra it solidifies the thought and intention. Not every day is good but there's something good in every day. Even if it's one small thing that gives you a sense of gratitude that's really grounding and it can help shift your perspective."

Stretching your body after you wake up or doing a sun salutation can help to get your blood flowing and your body moving in the morning.

It's also important to prioritize self-care. "Make stress relievers like enjoyable activities a non-negotiable right now," Cardwell said. That may include knitting, taking an extra-long shower or bath, reading, taking a tea break, enjoying a glass of wine or calling family members. Even better, schedule these stress relievers into your day just like mealtimes and other obligations.

"We're taking stock of what's important ... and (our) health is important. Doing these things now can help you deal with the stress of right now," Cardwell said.

It can also keep you healthy and feeling good well into the future, too. That's a gift from quarantine life if there ever is one.

The-CNN-Wire & 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved.

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Integrative Medicine in Child Neurology: What Do Physicians Know and What Do They Want to Learn? – Physician’s Weekly

Tuesday, June 2nd, 2020

Pediatric neurology patients frequently use integrative medicine; however, providers may feel uncomfortable or unfamiliar with these therapies. Child neurologist attitudes toward integrative medicine and educational needs in integrative medicine have not been assessed. A national, anonymous survey was distributed to Child Neurology residents (n=294) and program directors (n=71) to assess attitudes toward specific integrative medicine modalities, practices in discussing integrative medicine with patients, and perceived need for a curriculum on integrative medicine; 61 (17%) partially and 53 (15%) fully completed the survey. Comparative analyses applied chi-square and independent tests. Qualitative content analysis was performed on free text responses. Most providers surveyed consider mind and body practices safe (93% of respondents) and effective (84%), but have concerns about the safety of chiropractic manipulation (56% felt this was harmful), and the efficacy of homeopathy (none considered this effective). Few inquire about patient integrative medicine use regularly. Child Neurology residents are interested in further education on this topic.

PubMed

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Create a "healing" home with lighting, color and plants – AZFamily

Tuesday, June 2nd, 2020

Creating a healthy, healing environment for our family is so important as we navigate the stress and anxiety of this time. 75% of the immune system is the result of environmental and lifestyle factors. Top Immune Health Expert, Board Certified Integrative MD Dr. Taz, shares easy ways to create a healing home by reducing toxicity and activating our senses.

HOW TO CREATE A HEALING HOME with Dr. Taz

1) Lighting: Create ambient, soft light with lots of natural light to help enhance mood and lower cortisol. Replace fluorescent bubs, led bulbs. Consider sun lamps. Natural light is the most beneficial to the body.

2) Color: Color can be healing and color influences our feelings. White color on walls, dcor and furniture leads to a feel of clean and serenity. Teal accents in a room or overall color scheme of a house are associated with purity, relaxation and calmness. If someone needs to benefit from being in a relaxing envornment considere adding teal to the room. Red embodies power, vitality, energy. Rooms that need to be productive can utilize having red incorporated into their dcor. Magenta provides emotional balance and Yellow gives off a sense cheerfulness. Depending on the room and purpose, consider color to make the most out of the space.

3) Air: Household plants reduce indoor air pollution. My favorite house plants include: Peace Lily, Ferns, Aloe, Snake Plants, and Lemongrass. All plants have different needs for growth so make sure when choose a plant it is in a place and environment where it thrives. Plants also give us a way to feel closer to nature and be connected to mother earth.

Dr. Taz Bhatia, M.D. is a board-certified integrative medicine physician and wellness expert, who gained national recognition as a best-selling author of the books, What Doctors Eat, The 21 Day Belly Fix, and Super Woman RX. Her integration of Eastern medical wisdom with modern science, along with her unique Power Type discovery, has led to featured segments on The Today Show, Dr. Oz, Live with Kelly & Ryan and eventually the premiere of own PBS special Super Woman RX with Dr. Taz.

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