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Archive for the ‘Immune System’ Category

Explained: How the immune system goes awry in severe Covid-19 cases – The Indian Express

Saturday, August 15th, 2020

By: Express News Service | New Delhi | Updated: August 14, 2020 9:11:20 amA doctor attends to a Covid-19 patient in Argentina. (AP Photo: Natacha Pisarenko)

Why are some Covid-19 cases more severe than others? A new study has uncovered deviations and lapses in the immune system that appear to spell the difference between severe and mild cases of Covid-19.

The difference, the study suggests, may stem from how our evolutionarily ancient innate immune system responds to SARS-CoV-2, the novel coronavirus that cases Covid-19. The innate immune system rapidly senses pathogens, and immediately launches a somewhat indiscriminate attack on them. It also mobilises precisely targeted, but slower sharp-shooter cells from the adaptive immune system (which is different from the innate immune system).

These findings reveal how the immune system goes awry during coronavirus infections, leading to severe disease, and point to potential therapeutic targets, senior author Bali Pulendran of Stanford Medicine said in a statement. The study is published in Science.

The researchers analysed the immune response in 76 people with Covid-19 and in 69 health people. They found enhanced levels of molecules that promote inflammation in the blood of severely ill patients. Three of these molecules are known to be associated with lung inflammation in other diseases, but had not been shown previously in Covid-19 infections.

Source: Stanford Medicine News Center

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Are you immune to COVID-19 for three months after recovering? Its not clear – WTOP

Saturday, August 15th, 2020

It's the question everyone wants answered: How long are we protected from catching COVID-19 after we've recovered from the novel coronavirus?

Its the question everyone wants answered: How long are we protected from catching Covid-19 after weve recovered from the novel coronavirus and what does that really mean?

Last week, the US Centers for Disease Control and Prevention updated its quarantine guidelines online to say that people who have recovered from Covid-19 do not need to quarantine or get tested again for up to three months but the agency clarified in a statement to CNN on Friday that does not mean that people are immune to reinfection.

People who have tested positive for COVID-19 do not need to quarantine or get tested again for up to 3 months as long as they do not develop symptoms again, the CDC guidance stated.

A CDC spokesperson said the guidance is based on the latest science about COVID-19 showing that people can continue to test positive for up to 3 months after diagnosis and not be infectious to others.

Yet this science does not imply a person is immune to reinfection with SARS-CoV-2, the virus that causes COVID-19, in the 3 months following infection. The latest data simply suggests that retesting someone in the 3 months following initial infection is not necessary unless that person is exhibiting the symptoms of COVID-19 and the symptoms cannot be associated with another illness, the CDC statement said.

I think this is an incredibly sticky wicket, as the British would say, said Dr. William Schaffner, a professor of preventive medicine and infectious diseases at Vanderbilt University School of Medicine in Nashville, who was not involved in the CDC guidance.

We think antibodies correlate with protection, but we dont really know that yet, Schaffner said.

Practical applications, Schaffner added, are still a long way off. Can a person who has antibodies begin to date or stop wearing a mask, for example? Absolutely not, he said emphatically.

Our adaptive immune system, designed to target a specific and previously recognized invader, contains two main cellular components B cells and T cells. Studies on immunity so far have focused mainly on B cells, a type of white blood cell programmed to find and bind to foreign invaders.

Once it has attached itself to a virus such as the novel coronavirus that causes Covid-19, a B cell copies itself and churns out antibodies, eventually creating a mega-army of neutralizers for that particular invader, said CNN Chief Medical Correspondent Dr. Sanjay Gupta in an explainer on virus immunity.

Unfortunately, a few recent studies have found that antibodies to this particular coronavirus can fade away pretty quickly especially in people who have had mild cases of Covid-19, Gupta said.

A pre-print paper (meaning it has not been published in a peer-reviewed journal) released in July found antibody responses appear to decline 20 to 30 days after Covid-19 symptoms first appear.

This study has important implications when considering protection against re-infection with SARS-CoV-2 and the durability of vaccine protection, the researchers wrote in the paper.

In June, a small study found that people who have coronavirus infections but never develop symptoms could have weaker immune responses to the virus.

That study found that a group of about three dozen Covid-19 patients who were asymptomatic had levels of antibodies that were significantly lower than what was found among patients who had mild symptoms a finding that suggests the asymptomatic patients had weaker immune responses.

In early July, a Spanish government study found that just 5% of people in Spain have coronavirus antibodies and in a potentially worrying development, the study also indicated that peoples immunity to coronavirus wanes after just a few weeks. The findings show that 95% of Spains population remains susceptible to the virus.

This means that any perceived immunity can be incomplete, transitory and then disappear, said Dr. Raquel Yotti, head of the Carlos III Health Institute, in a news conference at the time. The institute is a key government agency leading the study.

Science is hoping that Covid-19 will also trigger an immune response from another arm of the adaptive immune system T cells. One type, called a memory T cell, helps the body remember a specific invader in case it comes back.

A recent study found such memory T cells in people infected with SARS-CoV-2, the novel coronavirus that creates the disease called Covid-19. That finding leads to speculation that some people might get milder cases of Covid-19 because their T-cells are reacting to exposure to similar coronaviruses encountered in the past.

The virus SARS-CoV-2 belongs to a large family of coronaviruses, six of which were previously known to infect humans. Two are deadly: SARS-CoV-1, the virus responsible for the outbreak of Severe Acute Respiratory Syndrome (SARS), which ended in 2004; and MERS-CoV, the virus that causes Middle East Respiratory Syndrome (MERS).

The other four cause the common cold, and because they circulate widely each year, its possible many people may have already been exposed to one of these so-called cousins of the novel coronavirus.

Theyve been studied and we know that after you had a cold, you develop antibodies to that particular human strain of coronavirus and you will be protected, but it turns out the protection begins to wane after about a year, Schaffner said.

Now when Covid-19 came along, we wondered how much protection are you going to get from this virus? And if you get protection, how long does it last? he added. We dont know that behavior yet.

Another page on the CDC site, updated in June, refers to the uncertainty that exists surrounding the role of antibodies in future infections.

Having antibodies to the virus that causes COVID-19 might provide protection from getting infected with the virus again. If it does, we do not know how much protection the antibodies might provide or how long this protection might last, the CDC says in regard to testing.

Until science knows more about how long immunity lasts, Schaffner advised staying the course of what is known to work: hand-washing, social distancing, avoiding crowds and wearing masks.

Dont go around looking for reasons not to wear the mask, just wear it. Get used to it, Schaffner said. We want to all be in this together to affirm our solidarity.

Editors note: This article has been updated to include comment from CDC clarifying its quarantine guidance.

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Cleveland Clinic: Four ways to boost your immune health – WKYC.com

Saturday, August 15th, 2020

Amid the pandemic, staying healthy is a top priority for most.

CLEVELAND As the state of Ohio continues it's fight against thecoronavirus pandemic, staying healthy seems to be a top priority for everyone.

But outside of washing your hands, not touching your face and proper social distancing, how can you increase your health and overall wellness? The Cleveland Clinic recommends boosting your immune system.

You diet can have a huge impact on your immune Health.

I believe in the power of immune-boosting foods, says Dr. Darling. Choosing whole, unprocessed foods does wonders for overall health, says Preventive medicine physician and wellness expert Sandra Darling.

She suggests adding foods like garlic, prebiotics, vitamin C-rich foods, and antioxidants to your diet to give your system a boost.

Listen, we know it's hard, but living under constant stress is detrimental to the body. Too much stress "cause causes the body to produce too much cortisol, the stress hormone. Over time, elevated cortisol lowers your resistance to fighting off infection and contributes to poor sleep and higher blood pressure," according to the clinic. Dr. Darling suggests making sure you get enough sleep, exercise and try meditation.

A little bit of positivity goes a long way. "Research shows that positive thoughts reduce stress and inflammation and increase resilience to infection while negative emotions can make you more susceptible to the common cold and flu," according to the Clinic.

If you've done all that you can when it comes to taking care of your immune system health, the Clinic recommends trying supplements and or essential oils.

The Clinic also recommends making sure you're taking time for yourself to rest in recharge. There's a lot going on in the world, you can't pour from an empty cup--so fill yours up!

For more information on the Clinic tips and resources, click here.

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The Right Wing Has A New Theory For Why The Pandemic Will End Soon: T Cells – BuzzFeed News

Saturday, August 15th, 2020

How the immune system responds to the coronavirus is a mystery that scientists are working furiously to unravel but their findings are being weaponized to make unfounded claims that the pandemic isnt a big threat.

That became clear this week, when President Donald Trump unveiled his newest science adviser on the coronavirus task force, neuroradiologist Scott Atlas. A senior fellow at Stanford Universitys Hoover Institution, he has steadily promoted unscientific views about the virus on Fox News and elsewhere, and has said there is zero excuse to not have the schools open in person. On Monday, Rush Limbaugh said Atlas was countering Fauci and cited the new advisers baseless theory that we could well be burned out of COVID by October. The reason: prior immunities.

Also on Monday, an unlicensed ophthalmologist and cryptocurrency investor, James Todaro, went viral on Twitter with a similarly misleading screed. Todaro, who was in the viral Americas Frontline Doctors video shared by Trump and removed from social media platforms for spreading misinformation about hydroxychloroquine, falsely claimed that T cell immunity meant many regions were already safe from infection and that lockdowns and mask-wearing were likely useless.

But infectious disease experts say these claims grossly distort the underlying science and what it means for public health guidelines which, right now, is nothing.

The apparent basis for these statements: a slew of recent studies finding that, in some places, 20% to 50% of people have immune cells that unexpectedly recognize the coronavirus. The newest of these studies suggests that these cells exist because they have responded in the past to similar viruses that can cause colds.

But the significance of this finding remains an open question, as its unclear what role, if any, these cells play in the bodys overall response to the coronavirus. And there is still no evidence that having these cells from a past cold will save you from getting COVID-19.

As T cells become yet another politicized flashpoint, scientists say the bottom line is that none of these findings make COVID-19 any less of a threat. The research should not be used, they warn, to argue against shutdowns and masks or for reopening workplaces and schools in a developed nation that has uniquely failed to control the virus. Most of all, they reject the leap of logic that the research means society is close to herd immunity the point at which enough people are immune to a virus that it stops circulating.

Weve got 1,000 people dying a day in the country, Shane Crotty, an immunologist at the La Jolla Institute for Immunology who has worked on several of the recent T cell studies, told BuzzFeed News. Theres no change in what the virus is doing based on what I find out or anybody else finds out. The virus is doing its thing and were doing our best to understand it.

The claim that T cells could mean the pandemic will end in two months, he said, is a total misunderstanding and wishful thinking.

Since the outset of the pandemic, Crotty and scientists around the world have been racing to untangle how the virus wreaks havoc on the body and how the body fights back.

The immune system employs different mechanisms to recognize and attack intruders. Perhaps the best-known of the bunch are antibodies, the proteins that latch onto and neutralize viruses and other invading substances. But in people who recover from the coronavirus, antibodies may only protect against reinfection for three months, recent research suggests.

Another weapon in the immune systems armory is T cells, which come in an assortment of types and functions and are increasingly garnering scientific attention. In the Netherlands, Germany, Singapore, the United Kingdom, and the US, researchers have discovered that in some people, a specific subset of T cells recognized the new coronavirus, SARS-CoV-2, when exposed to it. This was surprising, because these kinds of T cells, by definition, were not expected to recognize a virus they had never encountered before.

In their paper published last week in Science, Crotty and his team reported an explanation for why these cells reacted. Using human blood samples collected prior to the pandemic, they found cells that reacted to both SARS-CoV-2 and to four other coronaviruses that cause common colds. These coronaviruses, the researchers said, were apparently similar enough to the new one to make the T cells cross-reactive. (Crotty likened SARS-CoV-2 to a pretty distantly related evil cousin.)

The finding has led scientists to speculate that these cross-reactive T cells could be behind one of the pandemics biggest mysteries: why the virus causes severe illness in some people but mild or no symptoms in others. The latter patients might be better equipped to handle an infection, having fought off related viruses before. Childrens immune systems have to fight off a lot of colds, so maybe this is why they seem to be relatively spared by the new virus.

For now, however, this theory is just that: a theory.

It could explain everything and it could explain nothing, Crotty said. Very truly, these cells may have no impact on the disease at all. And even if this theory were borne out, it would have significant limits: As he noted, colds are caused by hundreds of viruses, not just the four identified in the study.

Either way, these cells are still just one piece of the immune system, a highly intricate machine with all kinds of T cells and antibodies working independently and together to stamp out pathogens. The big, yet-to-be answered questions are which of these elements actually protect people from getting sick and for how long.

While T cells may offer some protection and thats not really known T cells would probably not just prevent a person from being infected altogether, said Angie Rasmussen, a virologist at Columbia University who is not involved with this research.

But uncertainty hasnt stopped pundits from twisting the research to make a point.

On July 23, before he was appointed to the White Houses coronavirus task force, Scott Atlas declared on Laura Ingrahams show that lockdowns would not eradicate the virus, that the US outbreak was not out of control, and that there is absolutely no reason to panic, arguments hed been making since the spring. That day, the nations case count passed 4 million.

Theres a lot of great data coming out about immunity, Atlas went on to say. Its probably not known to the public, but there is a lot of data that shows that people have immunity even people that didnt get the infection. He added, Thats probably due to this T cell immunity, and concluded, So I think people should be much more optimistic here. The Fox News host responded enthusiastically, saying shed been discussing T cells and what they could mean for herd immunity on the show for well over six weeks.

This week, Limbaugh cited Atlass theory to tell listeners that the pandemic was almost over. We could see by early October COVID-19 turn inert or dormant largely due to some underappreciated T cell, prior immunities from exposure to coronavirus, meaning colds and so forth, the conservative radio host explained. Some people who have come down with a cold over the course of the summer miraculously end up less likely to get COVID-19, according to Scott Atlas. And people that get colds, thats a large portion of the population.

Atlas directed a request for comment to White House spokesperson Judd Deere, who said in a statement that Atlas is a world renowned physician and scholar of advanced medical care and health care policy who, like all of the medical experts in the Administration, is working to carry out the Presidents number one priority: protecting the health and safety of the American people.

Deere added, We are all in this fight together, and only the media would distort and diminish Dr. Atlas highly acclaimed career simply because he has come to serve the President.

Around the same time Limbaugh was praising Atlass theory, a similar claim was gaining traction on James Todaros Twitter account. Todaro, an early and avid proponent of hydroxychloroquine, is an ophthalmologist who earned his medical degree at Columbia University. He has not practiced since 2018, according to his LinkedIn profile, and his Michigan medical license expired last year. He did not respond to a request for comment.

In his thread, Todaro claimed that Crottys studies and others were growing evidence of T-cell immunity. All those runny noses from the common cold prepared our T cells to fight COVID-19, he proclaimed. He calculated that if about 50% of people had T cell immunity prior to SARS-CoV-2, and an additional 10% to 20% of people were newly infected, then 60% to 70% of the population would be immune a threshold that he said reached herd immunity.

It is likely that many of the hardest hit regions of the world (e.g. Lombardy, NYC, Madrid, London, Stockholm) are now at herd immunity, he wrote. Lockdowns & mask ordinances (mostly coming after the peak) likely had little effect, with the exception of perhaps prolonging the spread.

Thats not at all what the T cell research suggests, however. Having these cells still means you can get infected, only maybe maybe not as badly as if you didnt have them.

Herd immunity implies immunity, not just fewer people getting severe disease, said Gideon Meyerowitz-Katz, an epidemiologist at the University of Wollongong in Australia. That means they do not catch it, do not spread it, they have this immunity that stops them from getting it in the first place.

Even if 50% of the population really were somehow immune to the virus, that wouldnt change the number of people who have been hospitalized and killed by the pandemic. As of Friday, the death toll in the US had exceeded 167,000. It doesnt change anything from the public health side of things, Meyerowitz-Katz said.

Nevertheless, Todaros 19-part thread has been retweeted more than 48,000 times. It has circulated among figures on the right, from a Minnesota state senator to an editor at the Conservative Review to an ex-lawyer who has been retweeted by Trump. Other retweeters included the World Health Organizations director of epidemic and pandemic diseases, and a Scottish historian who shared it with his more than 1 million followers: Interesting thread. And hopeful if true.

Crotty is not a heavy Twitter user he checks it about once a week but he felt compelled to respond once he saw how far the misinformation was spreading. It was just not understanding the science, he said.

He banged out a series of counterpoints, explaining why Todaros claims were dangerous and unfounded. Nothing about his findings, he stressed, should change what the public should already be doing to stem transmission. Wearing a mask is much more effective than hoping you and the people around you have pre-existing T cell memory. Wearing a mask stops infections.

His debunk was retweeted more than 3,700 times, a mere fraction of Todaros reach.

Rasmussen, the Columbia virologist, worried that most people watching Fox News or coming across Todaros tweets would never see Crottys attempt to correct the record. As she put it: Theyre just going to look at, Oh, heres this big thread on T cell immunity. This sounds great. We dont even need to worry about waiting for a vaccine.

And she pointed out that this isnt the first time during the pandemic that seemingly credible sources have injected misinformation into the mainstream.

Weve seen this a few times: People essentially using the clout of their credentials or their affiliations with a prestigious university to get them onto TV basically and amplify these messages, Rasmussen said. The overarching message, as she saw it, is the standard Trump administration downplaying of the severity of the pandemic, saying that this is not as a big of a deal as everybody makes it out to be. Which, of course, the epidemiological evidence of over 160,000 deaths suggests otherwise.

During an interview on Wednesday, it was still dawning on Crotty that his research had suddenly, unwittingly, become another political flashpoint.

2020, the immunologist said. The year when all kinds of unexpected things happen.

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Study: existing tuberculosis vaccine is safe, stimulates the immune system, and may also be effective against COVID-19 – Innovation Origins

Saturday, August 15th, 2020

It is the dream of both doctors and politicians: an existing vaccine, the safety of which has already been established and which can induce immunity to COVID-19. Part of the dream is already coming true, according to research by Radboudumc in Nijmegen. A vaccine against tuberculosis that has been used for years appears to have a general stimulating effect on the immune system. It, therefore, works effectively against several diseases. It remains to be seen whether COVID-19 is one of those.

The study compared groups of volunteers who may or may not have received a BCG vaccine in the last five years (before the corona pandemic) and showed that the vaccine is at least safe and does not pose any additional risk of COVID-19 complaints. The results of this study have now been published in Cell Reports Medicine.

The Bacille Calmette-Gurin or BCG vaccine is the most widely received vaccine in the world. Originally intended as a treatment for tuberculosis, it later became clear that it gives a long-term, general boost to the innate immune system. As a result, the vaccine also proved effective against other conditions. At the Radboudumc, Professor of Experimental Internal Medicine Mihai Netea does a lot of research into this effect, which is called trained immunity.

Most volunteers received the vaccine between April 2017 and June 2018. Doctor PhD student and first author of the article Simone Moorlag explains that the purpose of that study was to determine the difference in immune response between individuals. Weve now asked the same volunteers about disease and COVID-19 complaints during the coronary pandemic. We then compared these data with those of a group of healthy volunteers who did not receive a BCG vaccine.

What the comparison between the groups shows is that at least those who have received the vaccine have not become ill more often or have become more seriously ill. Therefore, the researchers conclude, it cant do any harm to vaccinate people with BCG. The data show a cautiously positive picture, with a lower number of sick people in the period March-May 2020 among the vaccinated group, and also fewer fatigue complaints.

For bigger conclusions, it is still too early. The researchers underline that the positive result was to be expected in view of the generally known effects of the BCG vaccine on healthy volunteers. Moreover, the study also has limitations that prevent conclusions from being drawn about the usefulness of the BCG vaccine for the coronavirus. Mihai Netea: It is very important to be able to confirm that someone who has been vaccinated with BCG does not experience any adverse effects during the COVID-19 pandemic. But he also stresses that more study is needed to determine if this vaccination against COVID-19 can really help.

In order to be able to determine this, various studies are already underway, including a number of major studies in the Netherlands.

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These groundbreaking drugs will give us coronavirus immunity until vaccines are ready – BGR

Saturday, August 15th, 2020

Theres no guarantee theyll work, but health experts are hopeful that the first vaccine candidates to have reached the final stage of testing might be available as soon as this fall or winter. They still have to convince regulators that theyre safe and effective against the novel coronavirus, and thats the purpose of the large scale Phase 3 studies that are currently underway in the US and around the world. But even if some of these experimental drugs are ready for emergency use by late 2020, the general public wont have access to them until several months later, well into 2021. Logistics and manufacturing issues need to be ironed out before officials can start immunization campaigns, and healthcare professionals will rightfully have access to vaccines before the general public. Even then, only specific high-risk categories of people might qualify for the first round of vaccinations.

Thankfully, the world isnt putting all its eggs in the vaccine basket when it comes to crafting COVID-19 therapies. Several teams of scientists are testing drugs that might cure COVID-19, including a type of medicine that can also provide temporary immunity to healthy people. And the good news is that these new medications that can provide a limited immunity might be ready even before vaccines roll out.

Anyone following pandemic news closely is probably aware that several companies are studying drugs made of artificial antibodies. The so-called monoclonal antibodies aim to block the coronavirus from infecting cells. Theyre crafted using various technologies, but the purpose is the same. The antibodies can bind to the spike proteins found on the exterior of the virus and prevent them from linking up with cells. This is how the immune system works against any pathogen it creates neutralizing antibodies that can annihilate it.

Vaccines will teach the human body to prepare for COVID-19 by mimicking the virus and inducing neutralizing antibodies. Thats how long-term immunity can be obtained. Its unclear how long the protection will last, but vaccine immunity should significantly outlast monoclonal antibody immunity. Thats because the artificial antibodies provide immunity themselves and the protection is only good as long theres a circulating supply in the bloodstream. Once they vanish, the body wont know how to make more antibodies when needed, which is what would happen after vaccination or after surviving the illness.

Monoclonal antibodies do have one significant advantage over vaccines. They can help COVID-19 patients recover, while vaccines can only prevent an infection. Plasma experiments have shown that antibodies from COVID-19 survivors can significantly improve the condition of COVID-19 patients. Monoclonal antibodies would work the same way. Theyll hopefully prevent complications and deaths, and they should also speed up recovery times.

These drugs could become a crucial tool in the coming months and could deliver results long before vaccines are widely available.

A vaccine takes time to work, to force the development of antibodies. But when you give an antibody, you get immediate protection, University of North Carolina virologist Dr. Myron Cohen told The Associated Press. If we can generate them in large concentrations, in big vats in an antibody factory we can kind of bypass the immune system.

These drugs would be a really momentous thing in our fight against COVID, the doctor said.

The AP story runs through the various monoclonal antibody drugs that are currently in testing, some of which weve covered before. Eli Lilly has already started manufacturing its drug in the hopes that current studies will prove its effectiveness. Regeneron Pharmaceuticals already inked a $450 million deal with the US governmentand its making a dual antibody compound that should work even if the virus mutates.

Amgen, Adaptive Biotechnologies, Tychan, and Vir Biotechnology have also crafted various monoclonal antibodies that might work against COVID-19. Another team of scientists created antibody-like nanobodies and turned them into an aerosol that could be used with a nebulizer or inhaler.

Some of the drugs would be administered intravenously, and the antibody supply could last as long as a month for some candidates, but the protection could be extended to two months by increasing the dose. Subsequent shots would be needed to prolong the protection. Its unclear how much these drugs will cost or how soon theyll be available, but all sorts of clinical trials are already underway. Some are looking at monoclonal antibody drugs as treatment for COVID-19, while others are studying their capability to provide limited immunity to at-risk patients.

Dr. Anthony Fauci is cautiously optimistic about these drugs, just like with vaccines. Im heartened by the experience that we had with Ebola, he said. Its the success with our Ebola program that gives Regeneron hope that we can potentially do this again.

Chris Smith started writing about gadgets as a hobby, and before he knew it he was sharing his views on tech stuff with readers around the world. Whenever he's not writing about gadgets he miserably fails to stay away from them, although he desperately tries. But that's not necessarily a bad thing.

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These are the foods that strengthen your immune system.Dont stop consuming them! – Explica

Saturday, August 15th, 2020

He immune system it is responsible for attacking and destroying bacteria, viruses and all infectious organisms that try to penetrate the body. But like any defense mechanism it requires good maintenance to strengthen it.

Spinach, lettuce, carrot, pumpkin, tomato, beet, strawberries and cherries. Source of Vitamin A, responsible for the production of cells immune known as T lymphocytes.

Foods rich in vitamin B12 Vegetables source of vitamin C

Fish, poultry, eggs, milk, derivatives of dairy products and legumes. Rich in b12 vitamin, key in the maintenance of the central nervous system and in the proper functioning of the body.

Vegetables source of vitamin C

Green leafy vegetables like broccoli, cauliflower and bell peppers, citrus fruits like orange, lemon, tangerine, kiwi and apple. Source of vitamin C, responsible for preventing the entry of infections through the respiratory tract.

Nuts (peanuts, almonds, hazelnuts and pine nuts), asparagus, fish and olive, sunflower, rapeseed, wheat germ and hazelnut oils. Rich in Vitamin E, has antioxidant properties and its function is to strengthen the immune system.

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Immune receptor thought to be linked to hearing loss in child cancer survivors confirmed in new study – Folio – University of Alberta

Saturday, August 15th, 2020

ByYOLANDA POFFENROTH and MICHAEL BROWN

Permanent hearing loss triggered by a common chemotherapy drug in half of children being treated for cancer may occur through a well-studied immune receptor, according to University of Alberta research.

The study confirms a long-held belief and sets the stage for the development of safe doses tailored to each childs genetic makeup.

For the study, recently posted in bioRxiv, Ghazal Babolmorad, a PhD student in the Faculty of Medicine & Dentistry, focused her research on the immune response children with cancer have to cisplatin, a platinum-based chemotherapy drug that is highly effective in fighting the disease, but leads to serious side effects in 90 per cent of patients. These side effects include kidney and heart damage as well as permanent hearing loss in upwards of 60 per cent of children.

If were able make cisplatin, an otherwise invaluable chemotherapeutic tool, safe for everyonenot just low-risk patientsit could be a game-changer for the quality of life of the children using cisplatin as their cancer therapy, said Babolmorad.

The platinum atom at the centre of cisplatin is responsible for killing cancer cells, but can also activate an immune receptor in the cell membrane, known as TLR4, that experts have long thought plays a role in inflammation. Immune receptors are proteins that detect the presence of a pathogenor something wrong, like a cancer celland generate a signal to combat the pathogen.

The inflammation caused by the immune receptor that Babolmorad and her supervisor Amit Bhavsar were interested in occurs in the cochlea and results in damage to the auditory cells and, ultimately, hearing loss.

To better understand the mechanism behind this inflammation, th team treated two groups of auditory hair cell linessimilar to the ones found in human ears responsible for perceiving soundthat were essentially identical, except one of them lacked the TLR4 immune receptor, with platinum.

As expected, we only saw signals arise in the cells with TLR4, said Babolmorad. Basically, platinum, and cisplatin by extension, can activate the TLR4 immune receptor, which causes a response in the immune systemlike inflammation in the cochlea.

However, thanks to genetic variation, there are people who express a low level of this immune receptor, which means their immune system isnt activated and they have a low risk of developing hearing loss, said Babolmorad.

Babolmorad is now working with other U of A researchers, including groups led by chemistry professor Fred West and biology professor Ted Allison, to examine potential synthetic inhibitors that can block the TLR4 receptors.

Ghazal Babolmorads Graduate Studentship project is funded by the Stollery Childrens Hospital Foundation through the Women and Childrens Health Research Institute.

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Baker launches bread to support the immune-system – FoodManufacture.co.uk

Sunday, July 12th, 2020

This is not the first time Hovis has responded to consumer demands. In 2018 itlaunchedtwo new premium bread loavesin a bid to cater to the growing consumer demand for sourdough and seeded variants.

Glorious Grains is baked with seven different types of sprouted wholegrains, including rye, wheat, spelt, oats, barley, buckwheat and teff. The bread contains natural sources of copper, minerals including magnesium and phosphorus, and vitamin B1, said the firm.

Health-focused

Hovis Glorious Grains is the latest addition to Hovis health-focused range and follows the launch of Hovis Fabulous Fibre, a high-fibre option aimed at improving gut health.

Having listened to consumer demands, we are excited to launch our delicious new Glorious Grains loaf, which contains minerals and vitamin B1 and helps to support the immune system,saidNina Shanahan, head of marketing for Hovis

This is a great addition to our health-focused range which includes HovisFabulous Fibre, helping consumers reach the daily target fibre intake without compromising on taste. With more consumers demanding bread with additional nutritional benefits, Hovisis pleased to be able to answer these needs through our delicious and wholesome range.

Tackling food wast

Hovis said it has also been working to tackle hunger and food waste through donating to FareShare, the UK's largest and longest-running food redistribution charity. By July, Hovishad donated more than 95,000 loaves through FareShare.

In December 2019,Hovis signed up to the Trade Union Congress (TUC)Dying to Work charterin a bid to more effectively support employees affected by terminal illness.

Hovis Glorious Grains and Hovis Fabulous Fibre will be available in Sainsburys, Morrisons, Waitrose and Tesco in July. Hovis Fabulous Fibre is already on shelves in Tesco and Waitrose.

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Ways to boost your immune system to prevent COVID-19 – KZTV Action 10 News

Sunday, July 12th, 2020

COVID-19 cases continue to rise, and now most people are worried they will get the virus. But with a boosted immune system, contracting that virus is less-likely.

Lonnie Schwirtlich, M.D., Chief Medical Officer and Co-Owner of Physicians Premier, says "the people that come into our facilities, 20-30 percent of them are positive. These people then leave and go out there, theyre accidentally and sometimes - just carelessly, spreading this virus around."

Dr. Schwirtlich believes having a strong immune system will help protect many against the virus.

He says, first you want to protect your immune system from having to work so hard.

"In boosting your immunity, is to try and do everything so that you dont need to use that immunity," he said. "Obviously thats the spacing, staying away from big groups, staying away from closed rooms."

Then, boosting your immunity, begins with daily exercise. Dr. Shwirtlich says getting the heart rate up and warming up the body helps fight off the virus. Not to mention, releases stress and helps with blood sugar.

He says, you must remember to wash and sanitize whenever you touch objects. Especially wash your hands before touching your face or eating food.

Dr. Schwirtlich believes not smoking and vaping will also help tremendously, because then you are not inhaling particles in the air.

He said to also be mindful of alcohol consumption. The more we drink, the less our immune system works.

And he said to take daily vitamins, especially vitamin C and Zinc.

"Zinc actually, if it can get inside the cell, it helps stop replication of the virus," said Schwirtlich. He also states that for some patients who have been exposed or had a positive test, health experts were recommending 1000mg of vitamin C a couple times a day and 50 mg of Zinc per day.

Dr. Schwirtlich also believes using melatonin, tumeric and elderberry can help boost your immunity. He does say that taking vitamins could cause nausea.

With the boost in immunity, he says this could help lower the amount of cases. He believes Corpus Christi has not hit its peak just yet.

"We do need more hospital beds right now, and thats the difficult thing were dealing with. Is trying to be able to keep the number that are crashing and need to go into the hospital down to the point where we can tolerate it and be able to give them the best care possible."

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Boost Your Immune System To Keep At Bay Deadly Viruses Like The Corona – OdishaBytes

Sunday, July 12th, 2020

We need to understand our bodys immune system before washing our hands, maintaining social distance or taking precaution before sneezing. We have our skin, snot (mucus in the nose) microbiome and helpful bugs (gut bacteria) which compete with pathogens for food and space. These, in totality, make antimicrobial products and anti-viral compounds that are quite hostile to deadly viruses, including coronavirus.

If the pathogens move beyond, then the white blood cells attack them. There are others, which we term as vaccine, which confront the germs without our knowledge. This happens when we get immunity, which is the base of vaccination. It bypasses the defence system and protects the body with its own memory system so that we dont fall sick. At times, our immune system might get some blind spots, which means they dont recognise the bugs or the bugs might have evasion strategies. A healthy body and system ensures a good defence system.

Our bodies contain more cells belonging to microbes, such as bacteria and yeasts, termed as microbiome the gut bacteria. We live in a symbiotic relationship with our gut bacteria. Having the right ones around, that we evolved with, is best for our health. If we do anything that alters the ecosystem of these microbiome, its detrimental or bad for our immune system.

Not only do our microbes form protective barriers, they also programme our immune system. Older people, and those with diseases that are characterised by inflammation such as allergies, asthma, rheumatoid arthritis and diabetes tend to have less varied gut microbiomes.

To feed our gut microbiomes, we need more varied diet with lots of high-fibre foods. Being vegetarian isnt a pre-requisite for microbiomes health, but the more plant food one consumes, the better. The gut microbiome likes fibre, pulses and fermented food.

Yoghurt (curd) and pickles are among common fermented delicacies which are coming back to the Indian plates and helping a healthy microbiome. It has to be a continuous process, and not for just a few days or as a fashionable touch. It should be a permanent fixture. We have our own fermented rice pancake (pitha), which has disappeared from the Odisha kitchen.

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Getting Covid-19 twice: Why I think my patient was reinfected – Vox.com

Sunday, July 12th, 2020

Wait. I can catch Covid twice? my 50-year-old patient asked in disbelief. It was the beginning of July, and he had just tested positive for SARS-CoV-2, the virus that causes Covid-19, for a second time three months after a previous infection.

While theres still much we dont understand about immunity to this new illness, a small but growing number of cases like his suggest the answer is yes.

Covid-19 may also be much worse the second time around. During his first infection, my patient experienced a mild cough and sore throat. His second infection, in contrast, was marked by a high fever, shortness of breath, and hypoxia, resulting in multiple trips to the hospital.

Recent reports and conversations with physician colleagues suggest my patient is not alone. Two patients in New Jersey, for instance, appear to have contracted Covid-19 a second time almost two months after fully recovering from their first infection.

It is possible, but unlikely, that my patient had a single infection that lasted three months. Some Covid-19 patients (now dubbed long haulers) do appear to suffer persistent infections and symptoms.

My patient, however, cleared his infection he had two negative PCR tests after his first infection and felt healthy for nearly six weeks.

I believe it is far more likely that my patient fully recovered from his first infection, then caught Covid-19 a second time after being exposed to a young adult family member with the virus. He was unable to get an antibody test after his first infection, so we do not know whether his immune system mounted an effective antibody response or not.

Regardless, the limited research so far on recovered Covid-19 patients shows that not all patients develop antibodies after infection. Some patients, and particularly those who never develop symptoms, mount an antibody response immediately after infection only to have it wane quickly afterward an issue of increasing scientific concern.

Whats more, repeat infections in a short time period are a feature of many viruses, including other coronaviruses. So if some Covid-19 patients are getting reinfected after a second exposure, it would not be particularly unusual.

In general, the unknowns of immune responses to SARS-CoV-2 currently outweigh the knowns. We do not know how much immunity to expect once someone is infected with the virus, we do not know how long that immunity may last, and we do not know how many antibodies are needed to mount an effective response. And although there is some hope regarding cellular immunity (including T-cell responses) in the absence of a durable antibody response, the early evidence of reinfections puts the effectiveness of these immune responses in question as well.

Also troubling is that my patients case, and others like his, may dim the hope for natural herd immunity. Herd immunity depends on the theory that our immune systems, once exposed to a pathogen, will collectively protect us as a community from reinfection and further spread.

There are several pathways out of this pandemic, including safe, effective, and available therapeutics and vaccines, as well as herd immunity (or some combination thereof).

Experts generally consider natural herd immunity a worst-case scenario back-up plan. It requires mass infection (and, in the case of Covid-19, massive loss of life because of the diseases fatality rate) before protection takes hold. Herd immunity was promoted by experts in Sweden and (early on in the pandemic) in the UK, with devastating results.

Still, the dream of herd immunity, and the protection of a Covid-19 infection, or a positive antibody test, promise to provide, have taken hold among the public. As the collective reasoning has gone, the silver lining of surviving a Covid-19 infection (without debilitating side effects) is twofold: Survivors will not get infected again, nor will they pose a threat of passing the virus to their communities, workplaces, and loved ones.

While recent studies and reports have already questioned our ability to achieve herd immunity, our national discourse retains an implicit hope that herd immunity is possible. In recent weeks, leading medical experts have implied that the current surge in cases might lead to herd immunity by early 2021, and a July 6 opinion piece in the Wall Street Journal was similarly optimistic.

This wishful thinking is harmful. It risks incentivizing bad behavior. The rare but concerning Covid parties, where people are gathering to deliberately get infected with the virus, and large gatherings without masks, are considered by some to be the fastest way out of the pandemic, personally and as a community. Rather than trying to wish ourselves out of scientific realities, we must acknowledge the mounting evidence that challenges these ideas.

In my opinion, my patients experience serves as a warning sign on several fronts.

First, the trajectory of a moderate initial infection followed by a severe reinfection suggests that this novel coronavirus might share some tendencies of other viruses such as dengue fever, where you can suffer more severe illness each time you contract the disease.

Second, despite scientific hopes for either antibody-mediated or cellular immunity, the severity of my patients second bout with Covid-19 suggests that such responses may not be as robust as we hope.

Third, many people may let their guard down after being infected, because they believe they are either immune or incapable of contributing to community spread. As my patients case demonstrates, these assumptions risk both their own health and the health of those near them.

Last, if reinfection is possible on such a short timeline, there are implications for the efficacy and durability of vaccines developed to fight the disease.

I am aware that my patient represents a sample size of one, but taken together with other emerging examples, outlier stories like his are a warning sign of a potential pattern. If my patient is not, in fact, an exception, but instead proves the rule, then many people could catch Covid-19 more than once, and with unpredictable severity.

With no certainty of personal immunity nor relief through herd immunity, the hard work of beating this pandemic together continues. Our efforts must go beyond simply waiting for effective treatments and vaccines. They must include continued prevention through the use of medically proven face masks, face shields, hand washing, and physical distancing, as well as wide-scale testing, tracing, and isolation of new cases.

This is a novel disease: Learning curves are steep, and we must pay attention to the inconvenient truths as they arise. Natural herd immunity is almost certainly beyond our grasp. We cannot place our hopes on it.

D. Clay Ackerly, MD, MSc is an internal medicine and primary care physician practicing in Washington, DC.

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Supplements for Immune System Market : The report gives immense knowledge on the competitive nature of key players – 3rd Watch News

Sunday, July 12th, 2020

Global Supplements for Immune System market- Report defines the vital growth factors, opportunities and market segment of top players during the forecast period from 2019 to 2025. The report Supplements for Immune System offers a complete market outlook and development rate during the past, present, and the forecast period, with concise study, Supplements for Immune System market effectively defines the market value, volume, price trend, and development opportunities. The comprehensive, versatile and up-to-date information on Supplements for Immune System market is provided in this report.

The latest research report on Supplements for Immune System market encompasses a detailed compilation of this industry, and a creditable overview of its segmentation. In short, the study incorporates a generic overview of the Supplements for Immune System market based on its current status and market size, in terms of volume and returns. The study also comprises a summary of important data considering the geographical terrain of the industry as well as the industry players that seem to have achieved a powerful status across the Supplements for Immune System market.

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In continuation using earnings, this section studies consumption, and global Supplements for Immune System market. This area also sheds light on the variance between ingestion and distribution. Export and Supplements for Immune System significance data are provided in this part.

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Supplements for Immune System market analysis aside from business, the information, and supply, contact information from manufacturers, consumers and providers can also be presented. Additionally, a feasibility study to asset and SWOT analysis for endeavors have been contained.

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Should You Have Immunity-Boosting Kadha, Turmeric Milk, Lemon Water Every Day? Experts Bust Some Myths – NDTV Food

Sunday, July 12th, 2020

Highlights

Are you being forced to sip on a warm kadha in place of evening tea, or gulp down lemon water in place of cold drink, or end your day with haldi wala doodh? Believe us, this is the story of every household these days. The Coronavirus pandemic made us realise the importance of having a good immunity and parents are straining every nerve to ensure building immunity in children and family members. Some may be doing it with discretion while some may be going that extra mile making hasty decisions based on hearsay.

If you don't know how much you should be having these immunity-boosting drinks, don't worry. We consulted some nutritionists to crack the code for you. They gave us some tips and some dos and don'ts to get rid of our confusion and mystery around these homemade immunity boosters.

The many benefits of drinking kadha every day have been doing the rounds of late. It is made by boiling a range of whole spices in water for some time, straining it and drinking it like tea. Spices like cinnamon, cardamom, peppercorns, cloves, cumin etc. are used to make this all-spiced tea. It is believed that these Indian spices have an innate ability to boost our immune system. This may be true except these very spices are also very hot in nature. Clinical nutritionist Ishi Khosla warns, "over-consumption of such spices may lead to other health issues like stomach problems, digestion problems, nausea and skin dryness. She advises against drinking kadha every day or giving it a break for a few days after having it continuously for a long time." Having it every alternate day couple of times a week may sound like a good plan!

(Also Read: ThisKadha May Be The Ideal Drink To Have Right Now For Good Immunity)

Kadha is made by boiling whole spices in water.

Turmeric (or haldi) is a gem of a food. It is true it greatly helps in building one's immunity but the same logic of over-consumption applies to turmeric as well. Ishi Khosla says, "if you want to have haldi wala doodh every day, you can, but make sure to add just a pinch of turmeric in your drink."

Turmeric milk is excellent for boosting immunity.

Lemon is a great source of vitamin C that plays a huge role in boosting the immune system, along with providing many other health benefits. Consultant Nutritionist Rupali Dutta says, "you can have the juice of up to 2 lemons a day for good health and strong immunity." However, you should know that lemon contains a high amount of citric acid which may affect the alkaline content of our body. Bangalore-based Nutritionist Dr. Anju Sood warns, "You should not have lemon juice if you are suffering from any gastric stress or extreme acid reflux."

(Also Read:5 Effective Vitamin C Drinks You Can Add To Your Immunity-Boosting Diet)

Lemon water is a good source of vitamin C.

Stay healthy and safe with good immunity. But, don't make any rash diet mistakes that may do more harm than good.

About Neha GroverLove for reading roused her writing instincts. Neha is guilty of having a deep-set fixation with anything caffeinated. When she is not pouring out her nest of thoughts onto the screen, you can see her reading while sipping on coffee.

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3 Lifestyle Tweaks That Can Help Boost Your Immunity – Femina

Sunday, July 12th, 2020

The author, Dr Manoj Kutteri, is the Wellness Director at Atmantan and has more than 20 years of experience in developing wellness programmes across India and overseas. He has extensive knowledge in mind-body medicine, Naturopathy, Ayurveda, Nutrition, Acupuncture, Yoga and Physical culture.

Image: 123RF

The immune system is our in-built army of cells and proteins that detects, registers and protects the body against any foreign bodies that may have invaded or entered it. It is responsible for keeping us healthy and illness free. The strength of the immune system determines the capacity of a person to tackle various physical, emotional, and environmental challenges.

With the COVID-19 pandemic spreading rampantly across the world, we need to focus on building up our immunity and actively seek a mindful lifestyle. However, it is not as easy as it sounds. The immune system is a complex mesh of several kinds of cells, each playing their role in defending the body against harmful microbes.

Image: 123RF

In addition to Naturopathic practices, here are small steps that you can take which reap astoundingly positive results:

The clich is true; your body is a temple, and you have to be careful of what you're feeding it.

While a once in a blue moon cheat day won't hurt, unmindful eating habits are the core reason for stunting the growth of your immune system. Nourish your body with vitamin-rich foods and give it sufficient amounts of fibre. Remember your immune system has nothing to do with the way your body looks.

For a healthy liver, cruciferous vegetables like Kale, Broccoli and Cabbage should be included in daily diet. A healthy liver ensures the body's natural detoxification process.

Getting your sleep cycle in sync is one of the biggest gifts you can give your body. The body requires about 8 hours of sound sleep to rejuvenate and reboot its systems. It has to be kept in mind that it's not only 8 hours of sleep, but the timely hours of sleep that matter too.

Often, we stress ourselves by staying up till 3 am thereby disrupting the normal functioning of our body that leads to obesity, stress, emotional imbalance and other illnesses.

Working out regularly has been scientifically proven to boost the immune system. Regular exercise mobilises the T cells, a type of white blood cell which guards the body against infection.

However, continuous rigorous workout weakens the immune system, leaving you prone to flu and viral infections. Low level of Vitamin D in the body has been termed as one of the significant reasons for respiratory problems. A brisk walk in the sunlight for 1015 minutes will ensure that enough Vitamin D is produced in the body.

These are simple but highly effective tweaks in your daily routine. The key is listening carefully to your body and conscious living, consistently.

Also Read: Yoga And Ayurveda For All-Natural Health During The COVID-19 Pandemic

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Yoga asanas and breathing exercises to boost immunity during monsoon, keep infections at bay – Times Now

Saturday, July 11th, 2020

Yoga asanas and breathing exercises to boost immunity during monsoon, keep infections at bay  |  Photo Credit: iStock Images

New Delhi: The monsoon season invariably brings with it water-borne infections, respiratory illnesses, allergies, and stomach disorders. But nature has provided us with an immune system, a highly advanced piece of technology in-built in the human body. The immune system protects us against harmful substances from the environment, diseases and harmful cells. There are two types of immune systems the active and the passive immune system. The main parts of the immune system are white blood cells, antibodies, the complement system, the lymphatic system, the spleen, the thymus, and the bone marrow.

By keeping both the mind and body strong, you can raise your immunity levels. This has to be combined with a proper diet that includes immunity building foods. The following yoga practices will help you to improve your immune system and develop your defences. Yoga stimulates the lymphatic system removing toxins from the body, conditions the lungs and respiratory tract, and ensures the optimal functioning of your organs. Research shows that even 20 minutes of yoga on a regular basis can boost your overall health.

Formation of the posture

Begin with Dandasana Ensure that your knees are slightly bent while your legs are stretched out forward Extend your arms upward and keep your spine erect Exhale and empty your stomach of air With the exhale, bend forward at the hip and place your upper body on your lower body Lower your arms and grip your big toes with your fingers Try to touch your knees with your nose

Breathing Methodology - Exhale while bending forward

In Sanskrit, Kapal means skull and Bhati means shining/illuminating. Therefore, this Kapalbhati Pranayam is also known as Skull Shining Breathing Technique.

Method

Add these asanas and flow to your regular exercise routine to protect your health during the monsoons. Equip yourself with the necessary protective gear like jackets, raincoats and rain boots to keep yourself dry. Choose only trusted sources when it comes to eating outside to prevent falling prey to any infections. With a little care, the monsoon can easily become the best season of the year.

Grand Master Akshar is a guest contributor. Views expressed are personal.

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Cancer trial to focus on protecting patients from COVID-19 infection – 100 Mile House Free Press

Saturday, July 11th, 2020

A national clinical trial this summer will focus on protecting cancer patients against severe COVID-19 infection by attempting to boost their compromised immune system.

Researchers from The Ottawa Hospital say they want to explore the potential of IMM-101, a preparation featuring a dead pathogen containing properties that can stimulate the first-response arm of the immune system.

Study lead Dr. Rebecca Auer, surgical oncologist and director of cancer research at the Ottawa Hospital, says it could help experts understand why some COVID-19 patients are relatively asymptomatic while others end up in intensive care or die.

The difference it seems between these two different presentations has to do with how strong your innate, or your sort of non-specific, first-line defence immune system response is to the virus, Auer said Wednesday.

And so were hoping that by boosting and stimulating this innate immune response, particularly in those vulnerable patients that have a reduced immune response to begin with, wed be able to prevent symptomatic infections and prevent serious infections.

Cancer patients are at much higher risk of severe complications from COVID-19 because chemotherapy, cancer surgery and radiation treatments suppress innate immunity even further.

Auer points to an urgent need to protect them while the world waits for an effective COVID-19 vaccine, which could take another year or more to develop, test, and implement.

A successful trial could also protect cancer patients against other respiratory infections as well as the coming flu season, says Auer, noting the threat of illness is a fairly big problem for those undergoing treatment.

A study demonstrated that about 13 to 15 per cent of cancer patients will have to delay or stop their treatment because of influenza during the average flu season, she says.

And also cancer patients dont respond as well to the influenza vaccine every year because their immune system isnt as strong. So we think that the IMM-101 may in itself be able to help prevent symptomatic influenza infections.

Auer says IMM-101 has also been tested elsewhere for its anti-cancer properties and that, too, will be examined in this trial, although its not the primary objective.

The researchers say the bacteria, Mycobacterium obuense, is safe to use in cancer patients because it has been killed by heat.

The Canadian study will recruit 1,500 patients currently receiving cancer treatment, and participants will be randomly assigned to receive either regular care, or regular care plus IMM-101.

Auer says the treatment would be administered as an injection in the arm, to be followed by two more booster shots.

Researchers will follow patients for a year, watching for any respiratory infections and monitoring whether the treatment works and how long it lasts.

The trials will take place in eight centres located in Ontario, British Columbia and Quebec.

Researchers say people interested in participating should speak with their cancer specialist.

Researchers from the Ottawa Hospital came up with the idea and worked with the Canadian Cancer Trials Group at Queens University to design the trial.

Dr. Chris OCallaghan of the Queens University group notes cancer patients are also at greater risk of COVID-19 infection because they require regular medical care, making it difficult to adhere fully to public health guidelines.

These patients are unable to practice social isolation due to the need to regularly attend hospital to receive critically important cancer treatment, says OCallaghan, who will oversee the trial.

Auer says a successful trial of IMM-101 could also suggest usefulness in treating any patient with a reduced innate immune system, such as older patients with chronic illness.

She notes that the tuberculosis vaccine known as BCG which uses a similar formulation to IMM-101 but uses live bacteria instead of dead bacteria is being tested around the world to see if it can boost the immunity of health-care workers exposed to COVID-19.

Funding and in-kind support, valued at $2.8 million, comes from the Canadian Cancer Society, BioCanRx, the Ontario Institute for Cancer Research, The Ottawa Hospital Foundation, The Ottawa Hospital Academic Medical Organization, ATGen Canada/NKMax, and Immodulon Therapeutics, the manufacturer of IMM-101.

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How coronavirus affects the entire body – WXII The Triad

Saturday, July 11th, 2020

Related video above: Doctors noticing stroke-like symptoms in COVID-19 patientsCoronavirus damages not only the lungs, but the kidneys, liver, heart, brain and nervous system, skin and gastrointestinal tract, doctors said Friday in a review of reports about COVID-19 patients.The team at the Columbia University Irving Medical Center in New York City one of the hospitals flooded with patients in the spring went through their own experiences and collected reports from other medical teams around the world.Their comprehensive picture shows the coronavirus attacks virtually every major system in the human body, directly damaging organs and causing the blood to clot, the heart to lose its healthy rhythm, the kidneys to shed blood and protein and the skin to erupt in rashes. It causes headaches, dizziness, muscle aches, stomach pain and other symptoms along with classic respiratory symptoms like coughing and fever."Physicians need to think of COVID-19 as a multisystem disease," said Dr. Aakriti Gupta, a cardiology fellow at Columbia who worked on the review, in a statement. "There's a lot of news about clotting but it's also important to understand that a substantial proportion of these patients suffer kidney, heart, and brain damage, and physicians need to treat those conditions along with the respiratory disease."Much of the damage wrought by the virus appears to come because of its affinity for a receptor a kind of molecular doorway into cells called ACE2. Cells lining the blood vessels, in the kidneys, the liver ducts, the pancreas, in the intestinal tract and lining the respiratory tract all are covered with ACE2 receptors, which the virus can use to grapple and infect cells, the Columbia team wrote in their review, published in the journal Nature Medicine."These findings suggest that multiple-organ injury may occur at least in part due to direct viral tissue damage," the team wrote.Coronavirus infection also activates the immune system. Part of that response includes the production of inflammatory proteins called cytokines. This inflammation can damage cells and organs and the so-called cytokine storm is one of the causes of severe symptoms."This virus is unusual and it's hard not to take a step back and not be impressed by how many manifestations it has on the human body," Dr. Mahesh Madhavan, another cardiology fellow who worked on the review, said in a statement.Blood clotting effects appear to be caused by several different mechanisms: direct damage of the cells lining the blood vessels and interference with the various clotting mechanisms in the blood itself. Low blood oxygen caused by pneumonia can make the blood more likely to clot, the researchers said.These clots can cause strokes and heart attacks or can lodge in the lungs or legs. They clog the kidneys and interfere with dialysis treatments needed for the sickest patients.Damage to the pancreas can worsen diabetes, and patients with diabetes have been shown to be at the highest risk of severe illness and death from coronavirus.The virus can directly damage the brain, but some of the neurological effects likely come from the treatment. "COVID-19 patients can be intubated for two to three weeks; a quarter require ventilators for 30 or more days," Gupta said."These are very prolonged intubations, and patients need a lot of sedation. 'ICU delirium' was a well-known condition before COVID, and the hallucinations may be less an effect of the virus and more an effect of the prolonged sedation."The virus affects the immune system, depleting the T-cells the body usually deploys to fight off viral infections. "Lymphopenia, a marker of impaired cellular immunity, is a cardinal laboratory finding reported in 67-90% of patients with COVID-19," the researchers wrote.Doctors need to treat all of these effects when coronavirus patients show up in the hospital, the Columbia team said.There is some good news."Gastrointestinal symptoms may be associated with a longer duration of illness but have not been associated with increased mortality," the researchers wrote. Many of the skin effects, such as rashes and purplish, swollen "Covid toes," also clear up on their own.

Related video above: Doctors noticing stroke-like symptoms in COVID-19 patients

Coronavirus damages not only the lungs, but the kidneys, liver, heart, brain and nervous system, skin and gastrointestinal tract, doctors said Friday in a review of reports about COVID-19 patients.

The team at the Columbia University Irving Medical Center in New York City one of the hospitals flooded with patients in the spring went through their own experiences and collected reports from other medical teams around the world.

Their comprehensive picture shows the coronavirus attacks virtually every major system in the human body, directly damaging organs and causing the blood to clot, the heart to lose its healthy rhythm, the kidneys to shed blood and protein and the skin to erupt in rashes. It causes headaches, dizziness, muscle aches, stomach pain and other symptoms along with classic respiratory symptoms like coughing and fever.

"Physicians need to think of COVID-19 as a multisystem disease," said Dr. Aakriti Gupta, a cardiology fellow at Columbia who worked on the review, in a statement. "There's a lot of news about clotting but it's also important to understand that a substantial proportion of these patients suffer kidney, heart, and brain damage, and physicians need to treat those conditions along with the respiratory disease."

Much of the damage wrought by the virus appears to come because of its affinity for a receptor a kind of molecular doorway into cells called ACE2. Cells lining the blood vessels, in the kidneys, the liver ducts, the pancreas, in the intestinal tract and lining the respiratory tract all are covered with ACE2 receptors, which the virus can use to grapple and infect cells, the Columbia team wrote in their review, published in the journal Nature Medicine.

"These findings suggest that multiple-organ injury may occur at least in part due to direct viral tissue damage," the team wrote.

Coronavirus infection also activates the immune system. Part of that response includes the production of inflammatory proteins called cytokines. This inflammation can damage cells and organs and the so-called cytokine storm is one of the causes of severe symptoms.

"This virus is unusual and it's hard not to take a step back and not be impressed by how many manifestations it has on the human body," Dr. Mahesh Madhavan, another cardiology fellow who worked on the review, said in a statement.

Blood clotting effects appear to be caused by several different mechanisms: direct damage of the cells lining the blood vessels and interference with the various clotting mechanisms in the blood itself. Low blood oxygen caused by pneumonia can make the blood more likely to clot, the researchers said.

These clots can cause strokes and heart attacks or can lodge in the lungs or legs. They clog the kidneys and interfere with dialysis treatments needed for the sickest patients.

Damage to the pancreas can worsen diabetes, and patients with diabetes have been shown to be at the highest risk of severe illness and death from coronavirus.

The virus can directly damage the brain, but some of the neurological effects likely come from the treatment. "COVID-19 patients can be intubated for two to three weeks; a quarter require ventilators for 30 or more days," Gupta said.

"These are very prolonged intubations, and patients need a lot of sedation. 'ICU delirium' was a well-known condition before COVID, and the hallucinations may be less an effect of the virus and more an effect of the prolonged sedation."

The virus affects the immune system, depleting the T-cells the body usually deploys to fight off viral infections. "Lymphopenia, a marker of impaired cellular immunity, is a cardinal laboratory finding reported in 67-90% of patients with COVID-19," the researchers wrote.

Doctors need to treat all of these effects when coronavirus patients show up in the hospital, the Columbia team said.

There is some good news.

"Gastrointestinal symptoms may be associated with a longer duration of illness but have not been associated with increased mortality," the researchers wrote. Many of the skin effects, such as rashes and purplish, swollen "Covid toes," also clear up on their own.

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How coronavirus affects the entire body - WXII The Triad

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Canadian health care isnt immune to racism, experts say. Heres why – Global News

Saturday, July 11th, 2020

Police in Ontario shot 62-year-old Ejaz Choudry in his home. In New Brunswick, they shot Chantel Moore in her home and Rodney Levi at a friends barbecue. Prior to that, Regis Korchinski-Paquet fell from her balcony in Toronto while police were in her apartment. All four have died in the last six weeks; police called not because they committed crimes, but to check on their well-being.

Amid national and international reckonings over racism and police brutality, there have been widespread calls to use mental health practitioners not cops in moments of crisis. But while mental health is just one aspect of overall health (albeit a very important one), Canadian health care is not immune to the systemic racism impacting the countrys police forces.

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Experts say thats evident in a myriad of ways, from the coronavirus pandemics disproportionate impact on Indigenous people and Black people to other, non-COVID-19 headlines.

In Alberta, the minister of health recently ordered an independent investigation into the health authoritys handling of a noose taped to an operating room at the Grande Prairie Hospital in 2016. In B.C., the province is looking into allegations that some staff have been engaging in a racist game of whats-the-blood-alcohol-level of the (primarily) Indigenous patients who come to them seeking care.

But where defunding the police is an option, defunding health care is decidedly not. Nor, says Dr. Suzanne Shoush, does adding more Black, Indigenous and other racialized health-care providers solve the problem on its own you have to change the system.

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Like policing, health cares racism problem is systemic, says Shoush, who is a Black Indigenous doctor of Sudanese and Coast Salish heritage and the Indigenous health faculty lead for the University of Torontos family and community medicine department. Much like policing, she says, tackling it will require facing up to some uncomfortable truths.

It really all has to do with the blindness of privilege. People who have privilege are really, really blind to the fact privilege plays a role in where they are today.

Start with thesocial determinants of health: key factors that contribute to how healthy you, as an individual, are, as well as the group of people living around you.

Some you can control (to a degree), others you cannot: income and social status, employment and working conditions, education and literacy, childhood experiences, physical environments, access to health services, biology and genetic endowment, gender, culture, race and racism, and historical trauma.

These factors merge together, making Indigenous people amongthe highest-risk groups for diabetes and complications from diabetes, over-represented in HIV infection cases, tuberculosis cases and sexually transmitted infections, with a stroke rate nearly twice as high as non-Indigenous Canadians and a suicide rate among First Nations youth five to seven times higher than their non-Indigenous peers.

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For Black people in Canada, the data is harder to come by (a factor experts sayserves to worsen Black health). Buta research review from the Wellesley Institute, a non-profit that seeks to improve health equity in the Greater Toronto Area, indicates Black peoples health is harmed in part because they live in a racist environment. Much like Indigenous people, any racism experienced during their interactions with the system impacts their access to future care.

Furthermore, statistics compiled by the Black Health Alliance reveal that Black people make up 18 per cent of Canadians living in poverty even though they only represent less than three per cent of the total population. In Ontario, the risk of psychosis for people of Caribbean, East African and West African origin is 60 per cent higher than for others. And the likelihood that breast cancer kills Black women is 43 per cent higher than for white women.

Epidemiologist Nancy Kriegerboils it down to six pathways through which racism harms a persons health, including economic and social deprivation, socially inflicted trauma, inadequate or degrading medical care, and ecosystem degradation and alienation from the land the latter a recurring theme in reports like theRoyal Commission on Aboriginal Peoples, the Truth and Reconciliation Commission and theNational Inquiry into Missing and Murdered Indigenous Women and Girls.

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When you are displaced, you are not healthy, says Shoush, who recently wrote about how Canada was founded without the consent of Indigenous and Black people.

When we have a society that reflects and was founded in a non-consensual relationship, its very displacing, and this is why we see huge disparities in wellness, in health, chronic disease, life expectancy, child poverty.

Where some Indigenous people in Toronto will not consider going to the doctor, they might consider chatting with Cheryllee Bourgeois. They see her, after all, with her three children out in the community, at a powwow, at Thursday night socials at the Native Centre.

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Bourgeois is an exemption Mtis midwife working with Seventh Generation Midwives Toronto, as well as a professor in Ryerson Universitys midwifery education program. She became the citys first exemption midwife in 2018, following in the well-trodden footsteps of exemption midwives in Six Nations in southern Ontario.

Working under the exemption allows registered midwives (Bourgeois was one for more than a decade) to provide a broader scope of care to their clients to do Pap tests, address sexual and reproductive health and provide other health care not confined to pregnancy and the first six weeks of a babys life.

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The job itself is a tacit reminder of systemic racism in health care and recognition that increasing Indigenous access to health care involves community accountability and acknowledging Canadian history.

The health-care system was a very critical, key piece of the whole colonial history of the subjugation of Indigenous people, Bourgeois says.

There were such things as Indian hospitals where you were provided substandard care and where you were not allowed to go to the mainstream hospital.

Even now, it doesnt matter if Indigenous people give birth in rural, remote or urban settings in Canada, she says, their outcomes remain the same.

So that leads to something deeper, which is this very pervasive and strong systemic racism that exists within the system, affecting health outcomes, she says. In other words, its good to look at improving access, but if thats the sole focus of change then it doesnt actually solve the problem.

But Bourgeois patients grow by word of mouth, so-and-so telling their aunt or brother or cousin or friend youll be treated well there.

When the first wave of the coronavirus pandemic struck Canada this spring, Bourgeois and Shoush started Call Auntie, an information hotline for Indigenous people to ask their COVID-19 questions. In only a few short months, its morphed into something more.

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Its a form of accountability, Bourgeois says health-care workers can call ahead to certain testing centres to let them know an Indigenous person is incoming, a warm referral. Some people also ask about how to apply for the Canada Emergency Response Benefitor how they can get food delivered to their house because they have a compromised immune system.

Sometimes, Bourgeois says, people just want to talk through their concerns with a supportive listener. It isnt always about COVID-19. People call to say theyre living on the street Black people and Indigenous people are over-represented in Torontos homeless population and theyre scared of going to a shelter, so what can they do?

Its low stakes, Bourgeois says, because nothing they ask will get them put on a list of trouble clients.

They want to keep the line going after the pandemic.

For the Indigenous community, there is literally I dont want to say zero but really, theres zero trust in the health-care system that theyre actually going to be able to give them what they need, Bourgeois says.

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In pain? Labelled as drug seeking. Having a trauma response to something? Youre non-compliant. Treated badly so you dont go to your next appointment? Youre kicked out of care.

Its about so much more than extra funding, she says, because the current funding models dont take into account that need for community accountability the need for health-care providers like Bourgeois, who deliver babies, give people birth control shots, answer the questions people are scared to ask and then bring their children to Thursday night socials.

When health care your whole life has basically worked against you, youre going to do everything in your power to avoid it, she says.

Youre really not going to do anything if you dont change the system If you actually want to see a change in outcomes or a change in people engaging, you need to build trust.

Its important to remember that equitable access is not the same as equitable outcomes, says Kwame McKenzie, CEO of the Wellesley Institute, but he thinks people spend a lot of time thinking about the former rather than the latter.

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Whatd he like people to think about is: if everybody gets the same service, is the outcome the same? And is giving everybody the same service a reasonable thing to do?

Take something simple like treating high blood pressure, McKenzie says. One size does not fit all because the commonly used drugs do not work well for people of Caribbean and African origin. In other words, he says, equal access might be the same drug for everyone but it wont translate into equal outcomes.

Outcomes can be not as good because the intervention is the wrong intervention and you need a completely different intervention for different groups, he says.

You need a system that interacts with the social determinants of health because both your risk of illness and chance of getting better are very linked to who you are, how you live, what your income is.

More than a decade before health-care workers in British Columbia allegedly made a game out of guessing the blood alcohol levels of (predominantly) Indigenous people seeking care, Brian Sinclair wasignored to death in a Winnipeg ER in September 2008 presumed to be another drunken Indian rather than a 45-year-old with a severe bladder infection.

Sinclair was not ill but simply sleeping or intoxicated. This assumption, made and remade over and over in the 34 hours while Sinclair sickened and died in a hospital ER, is a striking and painful example of one of the structures of indifference that cost Brian Sinclair his life, as it has cost the lives of other Indigenous people in Canadian cities, wrote Mary Jane Logan McCallum and Adele Perry in their book Structures of Indifference: An Indigenous life and death in a Canadian City.

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It isnt that people dont recognize when things are problematic, Shoush says they do, and that realization isnt new. She thinks here of the Jane Elliott clip thats been circulating on social media.

In it, Elliott, a diversity educator, asks a room full of white people in the 1960s to please stand if theyd like to be treated the way Black people are treated. Nobody stands. She asks again. Nobody stands.

Then, she tells the room, That says very plainly that you know whats happening, you know you dont want it for you. I want to know why youre so willing to accept it or to allow it to happen for others.

Decades later, Shoush says more people are starting to understand how the structure of systems be it child apprehension, policing, incarceration or health care impacts individual outcomes, but more is needed.

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We understand that there are deep, deep injustices in our culture, in our society, but we always say that they should somehow pull themselves up, we should pull ourselves up by the bootstraps, not realizing that some people have been resourced from birth, she says.

That myth of individualism has to be shattered across every aspect of our society.

with files from The Canadian Press

The Call Auntie information hotline for Indigenous people is open daily from 4 to 9 p.m. at 437-703-8703. All messages left after hours will be responded to.

2020 Global News, a division of Corus Entertainment Inc.

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Canadian health care isnt immune to racism, experts say. Heres why - Global News

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How Does CBD Affect the Immune System and Autoimmune Disease? – The Cannabis Exchange

Saturday, July 11th, 2020

While more countries around the world continue to acknowledge the potential of CBD, the full biological effects of the cannabinoid are yet to be fully understood. However, some research demonstrates that CBD has anti-inflammatory and immunosuppressive properties.

But what does this mean for those that use CBD products, and who could potentially benefit from it?

CBD is one of the most common chemical compounds found in the cannabis plant. It is classed as a cannabinoid, along with Tetrahydrocannabinol (THC) and Cannabinol (CBN), and over a hundred other compounds in the plant. Cannabinoids are naturally occurring chemicals that have become known for their medicinal and wellness potential.

It is also clear that, in some cases, CBD might be used to treat particular diseases for which other available treatments have failed to be effective. Although we know that it produces effects in the central nervous system, in contrast to THC, which is psychoactive, CBD doesnt create the so-called high feeling.

In a nutshell, the immune system is the main defense our bodies have against diseases and other potentially damaging threats. When functioning properly, the immune system identifies and attacks intruders, such as bacteria, viruses, and parasites distinguishing them from our bodys healthy tissue.

Lymphocytes, or B cells and T cells, fight against antigens and they help the body to remember the once-beaten substances so that the next time the immune system can act quickly and effectively.

Despite the existence of the Endocannabinoid System only being confirmed by researchers in the 1990s, we already know that this system can play an important role in many bodily functions, including brain functions. Endocannabinoid receptors are expressed throughout the central nervous system, as well as in the human immune system.

Interactions between endocannabinoids and receptors are thought to influence mood, emotions, appetite, pain-sensation and memory, among other important physiological and cognitive processes. Phytocannabinoids (the most well-known are CBD and THC) interact with this system in similar ways to endocannabinoids.

According to research by James M. Nichols and Barbara L.F. Kaplan, it would appear that considering all the studies conducted on immune responses and inflammation, the data overwhelmingly demonstrate that CBD is immune suppressive and anti-inflammatory.While the definition of something being anti-inflammatory should be clear, CBD functioning as an immunosuppressant might require clarification.

As a potential immunosuppressant, CBD may reduce the immune systems inflammatory responses, promote apoptosis (cellular death), and prevent rapid cellular growth. In certain cases, these features may have a negative effect on a healthy humans immune system.

In addition, CBD exposure may also suppress the functions of cytokines, chemokines, and T cells all of which play an important role in immunodefense.

It has been suggested that CBD may have potential as an adjunct treatment for some autoimmune diseases.

An autoimmune disease is when the immune system begins to attack healthy cells, tissues, and organs. This can occur basically anywhere in the body, and it can result in particular body functions weakening and, in some cases, life-threatening conditions. The most common autoimmune diseases include Multiple Sclerosis (MS), Rheumatoid Arthritis, and Psoriasis.

Inflammation plays an important role in autoimmune diseases. As an anti-inflammatory,CBD might help the body to tackle the disease. In addition, CBDs immunosuppressive nature might be able to help it to deal with hyperactive immune systems that attack themselves.

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How Does CBD Affect the Immune System and Autoimmune Disease? - The Cannabis Exchange

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