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Archive for the ‘Genetics’ Category

Cell Size and Scale – Learn Genetics

Saturday, October 1st, 2016

Some cells are visible to the unaided eye

The smallest objects that the unaided human eye can see are about 0.1 mm long. That means that under the right conditions, you might be able to see an ameoba proteus, a human egg, and a paramecium without using magnification. A magnifying glass can help you to see them more clearly, but they will still look tiny.

Smaller cells are easily visible under a light microscope. It's even possible to make out structures within the cell, such as the nucleus, mitochondria and chloroplasts. Light microscopes use a system of lenses to magnify an image. The power of a light microscope is limited by the wavelength of visible light, which is about 500 nm. The most powerful light microscopes can resolve bacteria but not viruses.

To see anything smaller than 500 nm, you will need an electron microscope. Electron microscopes shoot a high-voltage beam of electrons onto or through an object, which deflects and absorbs some of the electrons. Resolution is still limited by the wavelength of the electron beam, but this wavelength is much smaller than that of visible light. The most powerful electron microscopes can resolve molecules and even individual atoms.

The label on the nucleotide is not quite accurate. Adenine refers to a portion of the molecule, the nitrogenous base. It would be more accurate to label the nucleotide deoxyadenosine monophosphate, as it includes the sugar deoxyribose and a phosphate group in addition to the nitrogenous base. However, the more familiar "adenine" label makes it easier for people to recognize it as one of the building blocks of DNA.

No, this isn't a mistake. First, there's less DNA in a sperm cell than there is in a non-reproductive cell such as a skin cell. Second, the DNA in a sperm cell is super-condensed and compacted into a highly dense form. Third, the head of a sperm cell is almost all nucleus. Most of the cytoplasm has been squeezed out in order to make the sperm an efficient torpedo-like swimming machine.

The X chromosome is shown here in a condensed state, as it would appear in a cell that's going through mitosis. It has also been duplicated, so there are actually two identical copies stuck together at their middles. A human sperm cell contains just one copy each of 23 chromosomes.

A chromosome is made up of genetic material (one long piece of DNA) wrapped around structural support proteins (histones). Histones organize the DNA and keep it from getting tangled, much like thread wrapped around a spool. But they also add a lot of bulk. In a sperm cell, a specialized set of tiny support proteins (protamines) pack the DNA down to about one-sixth the volume of a mitotic chromosome.

The size of the carbon atom is based on its van der Waals radius.

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FALCON v. LONG BEACH GENETICS INC | FindLaw

Thursday, August 4th, 2016

Leslie FALCON et al., Plaintiffs and Appellants, v. LONG BEACH GENETICS, INC. et al., Defendants and Respondents.

Plaintiffs and appellants Leslie Falcon, her minor daughter (at times collectively the Falcons) and Michael Patterson appeal from a summary judgment in favor of defendants and respondents Long Beach Genetics, Inc. (LBG), Esoterix, Inc. (Esoterix), and Laboratory Corporation of America (LabCorp) on plaintiffs' second amended complaint for negligence arising out of an erroneous deoxyribonucleic acid (DNA) test result used to determine minor's paternity. Plaintiffs advance several arguments as to why the trial court erred in granting summary judgment, but we need only decide whether the Civil Code section 47, subdivision (b) litigation privilege (the section 47(b) privilege or the litigation privilege) bars the action and whether the trial court abused its discretion by denying plaintiffs leave to amend. Because defendants' alleged conduct on which plaintiffs rely falls within the section 47(b) privilege, we conclude the trial court did not err in granting summary judgment, nor did it err by denying leave to amend the complaint. Accordingly, we affirm the judgment.

FACTUAL AND PROCEDURAL BACKGROUND

We set out the undisputed material facts as ascertained from the parties' moving and opposing papers (see Guz v. Bechtel National, Inc. (2000) 24 Cal.4th 317, 327) and state other facts and draw inferences from them in the light most favorable to plaintiffs. (Code Civ. Proc., 437c, subd. (c); Aguilar v. Atlantic Richfield Co. (2001) 25 Cal.4th 826, 843 (Aguilar).) Having said this, we are compelled to note the difficulty we have had identifying the evidence supporting plaintiffs' claimed disputes as to defendants' enumerated material facts pertaining to the section 47(b) privilege. Plaintiffs' opposing separate statements largely contain argumentative assertions in response to each listed fact, unsupported by the cited evidence.1 And, much of plaintiffs' evidence is directed to their assertion that LBG was not a licensed healthcare provider in the relevant time period, which is not relevant to the section 47(b) privilege issue. In that respect, plaintiffs' opposing separate statements are of little evidentiary value. (Cf. Tucker Land Co. v. State of California (2001) 94 Cal.App.4th 1191, 1201 [supplemental proffer of undisputed material facts of no evidentiary value where the facts were not supported by specific references to pages and lines in the depositions and cited exhibits].)

To further complicate review, plaintiffs make numerous factual assertions in their briefs without record citation. Accordingly, our review of the facts is also hindered by their failure to provide citations to the record that comply with California Rules of Court, rule 8.204(a)(1)(C). We are entitled to disregard such unsupported factual assertions even on de novo review of a summary judgment. (See Mueller v. County of Los Angeles (2009) 176 Cal.App.4th 809, 816, fn. 5 [The claimed existence of facts that are not supported by citations to pages in the appellate record, or not appropriately supported by citations, cannot be considered by this court.]; Stockinger v. Feather River Community College (2003) 111 Cal.App.4th 1014, 1025.)

LBG is a laboratory that conducted DNA paternity testing until 2005, when it was acquired by LabCorp. In the fall of 2003, Leslie Falcon and Patterson scheduled a free paternity test with the County of San Diego (County) to confirm that minor was Patterson's child. On September 26, 2003,2 County commenced a paternity proceeding in the San Diego County Superior Court entitled County of San Diego v. Michael Patterson (Super.Ct.S.D.County, 2004, No. DF177011). In connection with that proceeding, Patterson agreed to provide a genetic specimen for testing on October 30, 2003, which would be delivered to LBG for testing. LBG's testing location was at the superior court in downtown San Diego, and its family relationship testing was performed as part of its contractual relationship with County. It collected DNA samples from Patterson and the Falcons in order to assist County in determining minor's paternity.

In November 2003, LBG issued test results excluding Patterson as minor's biological father and mailed it to both parents. The test results were accompanied by a declaration of LBG custodian of records Christine D'Autremonte, certifying the records. On January 30, 2004, County sent Patterson a letter informing him that the blood test results revealed he was not minor's father. The test results, however, were erroneous, as they were based on the DNA markers of someone other than Patterson. Leslie Falcon did not discover the error until February 2008, in connection with her application to reopen minor's paternity case.

In November 2009, the Falcons sued defendants for negligence. The judicial council form complaint alleged that defendants negligently concluded and thereafter via declaration testimony informed the San Diego Superior Court and Plaintiffsthat through their DNA tests, which were 99.99 [percent] accurate[minor] was not the daughter of her actual father Michael Patterson, causing damage in November 2003. The Falcons further alleged they did not suspect, nor were they able to discover this error until the Defendant conducted further DNA tests in February 2008 and that the negligence caused and continues to cause both economic and non-economic damages to the Plaintiffs. Patterson was added as a plaintiff in July 2010.

Defendants moved for summary judgment and alternatively summary adjudication of issues. They argued (1) plaintiffs' claims were barred by the litigation privilege; (2) defendants owed no duty to plaintiffs; and (3) the complaint was barred by the one-year statute of limitations under the Medical Injury Compensation Reform Act (MICRA)3 and thus failed to state facts sufficient to constitute a cause of action. As to Patterson, defendants argued that even if the MICRA one-year limitations period did not apply, his claim was barred by the two-year general negligence statute of limitations.

Plaintiffs opposed the motion, filing separate but largely identical papers. In part, plaintiffs argued the section 47(b) privilege did not apply to LBG's negligent performance of the first paternity test and defendants owed a legal duty to plaintiffs as intended third party beneficiaries of the contract between County and LBG.4 Neither Patterson nor Leslie Falcon submitted a declaration in support of the motion. Instead, in their separate statements they cited evidence submitted by defendants, and later supplemented their showing with defendants' responses to requests for admissions. Plaintiffs lodged foreign authorities including Berman v. Laboratory Corporation of America (Okla.2011) 268 P.3d 68 (Berman), in which the Oklahoma Supreme Court held a plaintiff's negligence claim was not barred by an Oklahoma absolute privilege for communications made during or preliminary to a judicial proceeding, and LabCorp owed that plaintiff, a parent seeking to prove her child's paternity, a duty to conduct accurate DNA testing ordered by Oklahoma's Department of Human Services for child support purposes. (Id. at pp. 7172.)

At about the same time, Patterson applied ex parte to file a third amendment to the complaint to add a claim for punitive damages. He sought to allege that LabCorp had retested Falcon and Patterson's DNA in 2008 at the request of DCSS, but did not inform Falcon or Patterson until 2010, and further that LabCorp did not integrate LBG's data after its merger with LBG, which caused LabCorp's cross-referencing system to fail in 2007 to recognize the 2003 testing error. Patterson sought to allege that these failures constituted gross negligence warranting punitive damages. The trial court set a hearing on the motion for March 2, 2012.

Plaintiffs thereafter neglected to timely file their motion for leave to amend, and Patterson again sought ex parte an order shortening time to file the motion. In the amended pleading, Patterson additionally sought to challenge LBG's assertion it was a licensed health care provider for purposes of applying the MICRA statute of limitations, claiming LBG withheld evidence that proved otherwise. The trial court denied Patterson's request to shorten time and scheduled the motion for June 15, 2012, after the summary judgment hearing.

At oral argument on defendants' summary judgment motion, counsel argued extensively about the existence of litigation, the parties' knowledge of County's paternity proceeding, and their motivation for going to County for blood testing. The court asked counsel to focus on the connection between the DNA test and County's proceeding, and Patterson's counsel represented that the paternity test was a free service offered by County performed without any reference to MediCal or any paternity action. When pressed, however, to identify the record evidence of that assertion, counsel could not, and eventually offered to supplement her showing with materials from DCSS. The Falcons' counsel asked the court to allow them to amend the complaint to represent the facts, that the negligent gravamen of this, or the gravamen is the negligent conduct, not the noncommunicative conduct [sic]. Plaintiffs also sought to amend the complaint to allege that defendants had conducted a retest in 2007 but did not inform Patterson until 2010, breaching its contract with County and violating Family Code section 7552.

Ruling Berman, supra, 268 P.3d 68 was directly at odds with California authority, specifically Ramalingam v. Thompson (2007) 151 Cal.App.4th 491 and Gootee v. Lightner (1990) 224 Cal.App.3d 587, the trial court granted summary judgment in defendants' favor. Taking judicial notice of the existence of County's proceeding, the court ruled the gravamen of plaintiffs' complaint was communicative conduct barred by the section 47(b) privilege; that LBG performed the test in connection with the paternity proceedings initiated by County and plaintiffs' alleged injuries arose from the laboratory's communication of the test results to the parties in that action. The court denied plaintiffs' request for leave to amend the complaint to allege that LBG breached its duty to notify plaintiffs of its 2008 retest results under Family Code section 7552.5 and the contract between it and County. It reasoned that the amendment was unreasonably delayed, as the Falcons had filed the action in November 2009 and Patterson was added in July 2010, but the request to amend was not made until the April 2012 summary judgment hearing. It further ruled plaintiffs could not state a viable cause of action in any event.5 Plaintiffs appeal from the ensuing judgment.

DISCUSSION

I.Summary Judgment Principles and Standard of Review

Any party may move for summary judgment in any action or proceeding if it is contended that the action has no merit or that there is no defense to the action or proceeding. (Code Civ. Proc., 437c, subd. (a).) A defendant moving for summary judgment bears the burden of persuasion that one or more elements of the cause of action in question cannot be established, or that there is a complete defense thereto. (Aguilar, supra, 25 Cal.4th at p. 850; Code Civ. Proc., 437c, subd. (p)(2).) Such a defendant bears an initial burden of production to make a prima facie showing of the nonexistence of any triable issue of material fact. (Aguilar, at p. 850.) Once the defendant meets its initial burden of production, the burden shifts to plaintiff to demonstrate the existence of a triable issue of material fact. (Id. at pp. 850851.)

On appeal, we review the record and the trial court's decision de novo, liberally construing the evidence in support of the plaintiffs as the opposing parties and resolving doubts concerning the evidence in their favor. (Coral Const., Inc. v. City and County of San Francisco (2010) 50 Cal.4th 315, 336; State of California v. Allstate Ins. Co. (2009) 45 Cal.4th 1008, 1017.) Despite this review in plaintiffs' favor, plaintiff's evidence remains subject to careful scrutiny. [Citation.] We can find a triable issue of material fact if, and only if, the evidence would allow a reasonable trier of fact to find the underlying fact in favor of the party opposing the motion in accordance with the applicable standard of proof. (King v. United Parcel Service, Inc. (2007) 152 Cal.App.4th 426, 433; see Sangster v. Paetkau (1998) 68 Cal.App.4th 151, 163 [responsive evidence that gives rise to no more than mere speculation cannot be regarded as substantial, and is insufficient to establish a triable issue of material fact].)

II.The Section 47(b) Privilege Bars Plaintiffs' Negligence Claim

A.The Section 47(b) Privilege

The section 47(b) litigation privilege provides that a publication or broadcast made as part of a judicial proceeding is privileged. (Action Apartment Assn., Inc. v. City of Santa Monica (2007) 41 Cal.4th 1232, 1241.) The usual formulation is that the privilege applies to any communication (1) made in judicial or quasi-judicial proceedings; (2) by litigants or other participants authorized by law; (3) to achieve the objects of the litigation; and (4) that [has] some connection or logical relation to the action. [Citation.] The privilege is not limited to statements made during a trial or other proceedings, but may extend to steps taken prior thereto, or afterwards. (Action Apartment, at p. 1241, quoting Silberg v. Anderson (1990) 50 Cal.3d 205, 212; see also Hawran v. Hixson (2012) 209 Cal.App.4th 256, 282; Komarova v. National Credit Acceptance, Inc. (2009) 175 Cal.App.4th 324, 336 [communications with some relation to an anticipated lawsuit are within the privilege].) And judicial or quasi-judicial proceedings are defined broadly to include all kinds of truth-seeking proceedings, including administrative, legislative and other official proceedings. (Wang v. Heck (2012) 203 Cal.App.4th 677, 684.) [T]he communication must be in furtherance of the objects of the proceeding, which is part of the requirement that the communication be connected with, or have some logical relation to, the [proceeding], i.e., that it not be extraneous to the [proceeding]. (Hawran, at pp. 282283, quoting Action Apartment, at p. 1251.)

The litigation privilege is absolute and broadly applied regardless of malice. (Jacob B. v. County of Shasta (2007) 40 Cal.4th 948, 955.) Its purposes are to afford litigants and witnesses free access to the courts without fear of being harassed subsequently by derivative tort actions, to encourage open channels of communication and zealous advocacy, to promote complete and truthful testimony, to give finality to judgments and to avoid unending litigation. (Ibid.) It promotes effective judicial proceedings by encouraging full communication with the courts. (Ibid.) Accordingly, doubts as to whether the privilege applies are resolved in its favor. (Hawran v. Hixson, supra, 209 Cal.App.4th at p. 283; Wang v. Heck, supra, 203 Cal.App.4th at p. 684.)

Despite its broad and absolute nature, the litigation privilege only protects publications and communications. Thus, a threshold issue in determining the applicability of the privilege is whether the defendant's conduct was communicative or noncommunicative The distinction between communicative and noncommunicative conduct hinges on the gravamen of the action That is, the key in determining whether the privilege applies is whether the injury allegedly resulted from an act that was communicative in its essential nature. (Rusheen v. Cohen (2006) 37 Cal.4th 1048, 10571058; see also Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at pp. 12481249.) And, if the gravamen of the action is based on a communicative act, the litigation privilege extends to noncommunicative acts that are necessarily related to the communicative conduct Stated another way, unless it is demonstrated that an independent, noncommunicative, wrongful act was the gravamen of the action, the litigation privilege applies. (Rusheen, at p. 1065; Tom Jones Enterprises, Ltd. v. County of Los Angeles (2013) 212 Cal.App.4th 1283, 1295.) The interpretation of Civil Code section 47, subdivision (b) is a pure question of law that we review independently. (Wang v. Heck, supra, 203 Cal.App.4th at p. 684.)

B.Challenges to the Elements of the Section 47(b) Privilege

Patterson contends these facts do not meet the elements of the section 47(b) privilege, that is, the existence of an underlying judicial or quasi-judicial proceeding, or the necessary communication made by litigants or other participants authorized by law, to achieve the objects of the litigation, having some connection or logical relation to the action. (See Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1241.) Specifically, Patterson maintains there is no evidence of any dispute, or that a true case with appropriate pleadings were [sic] filed prior to testing, and there is no evidence he and Falcon had initiated the case or were participating in litigation. He suggests plaintiffs did not need to engage in a paternity fight because they were both engaged and happy custodial parents, and the DNA test had no connection or logical relation to the action because he was not refusing to support his child.

Falcon includes similar arguments in her reply brief on appeal. In part, relying on County of San Diego v. Gorham (2010) 186 Cal.App.4th 1215, a case not involving the section 47(b) privilege, she argues service of summons and complaint of County's action was a prerequisite to any determination that plaintiffs were litigants in that action, and there was no personal jurisdiction over the parties, violating their rights to due process. She also argues the plaintiffs underwent testing of their own free will and did not respond to any court order or ask to be involved in any litigation.

These contentions are meritless. The trial court properly took judicial notice of the existence and pendency of County's superior court proceeding against Patterson (Evid.Code, 452, subd. (d) [judicial notice proper of records of any court of record of any state of the United States]; People v. Lee (2011) 51 Cal.4th 620, 651, fn. 20), and there is no dispute Patterson consented to the defendants' DNA testing. As we explain below, Patterson's stipulation constituted a general appearance in the action, conferring jurisdiction over his person. DNA testing was sought to assist County in the then pending proceeding to ascertain minor's paternity; defendants' acts in conducting the test and communicating its results plainly furthered that goal, and had some logical relation to the action. (Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1241.) None of the authorities relied upon by Patterson and the Falcons support the proposition that application of the section 47(b) privilege requires a party or participant initiate or be cognizant of pending or contemplated litigation. More specific to this case, plaintiffs' arguments give us no basis to conclude a party's willingness to undergo DNA testing, where that testing is performed under contract with a County for purposes of a pending paternity proceeding, somehow negates any connection or logical relation between the test and the paternity action.6

C.Plaintiffs Allege Their Injury Resulted from the Defendant's Communication of the Erroneous Test Results to County

Characterizing the trial court's decision as inequitable, illogical, and contrary to the Legislature's intent in enacting Civil Code section 47, subdivision (b), plaintiffs contend the litigation privilege cannot apply to a free paternity test conducted negligently merely because the erroneous test results were communicated to County and the parties. They argue: The litigation privilege was intended to protect expert witnesses from being sued for their opinions, for the testimony they offer in court. But DNA paternity testing is mathematical, a test akin to throwing a switch and comparing two printed documents to determine if the marks on the two documents are identical. Plaintiffs assert the entire purpose of defendants' paternity test is to provide the court and the parents definitive proof of a child's father, and thus the distinction between the performance of the test itself and the inevitable communication of its results becomes meaningless, and would leave parties harmed by a negligently performed test without any legal remedy.

As stated above, plaintiffs squarely allege the basis for negligence liability is that defendants negligently concluded and thereafter via declaration testimony informed the San Diego Superior Court and Plaintiffs through their DNA tests [that minor] was not the daughter of her actual father Michael Patterson (Italics added.) Plaintiffs allege that this negligence caused damage in November 2003. Plaintiffs' allegations demonstrate their injuries resulted from an act that was communicative in its essential nature. (Rusheen v. Cohen, supra, 37 Cal.4th at pp. 10571058.) Accordingly, the litigation privilege extends not only to the defendants' communication of the genetic test results, but the noncommunicative act of the DNA testing itself that is necessarily related to the communication. (Id. at p. 1065.)

Under settled summary judgment standards, we are limited to assessing those theories alleged in the plaintiffs' pleadings. (Conroy v. Regents of University of Cal. (2009) 45 Cal.4th 1244, 1250 [the materiality of a disputed fact is measured by the pleadings, which set the boundaries of the issues to be resolved at summary judgment]; County of Santa Clara v. Atlantic Richfield Co. (2006) 137 Cal.App.4th at 292, 332; Laabs v. City of Victorville (2008) 163 Cal.App.4th 1242, 12531258 & fn. 7; Oakland Raiders v. National Football League (2005) 131 Cal.App.4th 621, 648.) The burden of a defendant moving for summary judgment only requires that he or she negate plaintiff's theories of liability as alleged in the complaint. A moving party need not refute liability on some theoretical possibility not included in the pleadings. [Citation.] [A] motion for summary judgment must be directed to the issues raised by the pleadings. The [papers] filed in response to a defendant's motion for summary judgment may not create issues outside the pleadings and are not a substitute for an amendment to the pleadings. (County of Santa Clara, at p. 332.) The function of the pleadings in a motion for summary judgment is to delimit the scope of the issues: the function of the affidavits or declarations is to disclose whether there is any triable issue of fact within the issues delimited by the pleadings. (FPI Development, Inc. v. Nakashima (1991) 231 Cal.App.3d 367, 381.) [A] plaintiff wishing to rely upon unpleaded theories to defeat summary judgment must move to amend the complaint before the hearing. (Oakland Raiders, at p. 648; see also County of Santa Clara, at p. 333; Laabs. v. City of Victorville, at p. 1257.)

Even if plaintiffs had specifically alleged that the basis for their claim was defendants' negligent testing, and not the communication of the test results via D'Autremonte's declaration, our conclusion would not change. The summary judgment evidence is undisputed that the test results were communicated to County and the parties for the purpose of County's paternity proceeding. Thus, defendants' testing and its communication to County are necessarily linked, and the injury would not have occurred but for communication of the results in the legal proceeding.

We are not convinced by plaintiffs' arguments otherwise. The distinction between an expert's opinion testimony, which plaintiffs assert is subject to the privilege, and underlying negligently performed scientific testing, which assertedly should fall outside the privilege, is simply not recognized by California authorities applying the section 47(b) privilege in analogous contexts. For example, in Block v. Sacramento Clinical Labs, Inc. (1982) 131 Cal.App.3d 386, the Court of Appeal held the litigation privilege applied to an action for professional negligence against a toxicologist for a negligently performed blood analysis provided to the district attorney to determine whether criminal charges were warranted. (Id. at pp. 387388.) The toxicologist had erred in his calculations of the amount of baby aspirin a baby would have ingested based on the salicylate concentration in its blood. (Id. at p. 388.) The plaintiff argued the toxicologist was liable if his lack of ordinary care caused foreseeable injury to her economic interests: [O]nce [the defendant] had made his erroneous preliminary determination that the child had ingested a large number of aspirins immediately prior to her death, his purpose was to provide that information to the District Attorney and to the court so that they would rely thereon. (Id. at p. 392.) The plaintiff argued there was no question her injuries were clearly foreseeable and in fact foreseen by the defendant. (Ibid.)

The Court of Appeal held this theory place[d] [the defendant's] communication of the report to the district attorney and, later, his testimony in the criminal proceeding, at the heart of the claim of liability Whether the matter be characterized as the publication of a negligently prepared report or the negligent publication of the report, plaintiff finds the duty upon which her theory of negligence relies in the foreseeable consequences of publication of the report in or related to the judicial proceeding. (Block v. Sacramento Clinical Labs, Inc., supra, 131 Cal.App.3d at pp. 392393.) Any other approach would substantially defeat the purpose of [the] privilege. (Id. at p. 394.) The court observed that the plaintiff at oral argument sought to escape the privilege by characterizing the action as arising out of the defendant's negligent conduct alone. (Id. at p. 393, fn. 10.) It concluded, however, that under any cognizable theory of duty, the negligent calculation formed the basis of [defendant's] communication and was privileged. (Ibid.) Block held the defendant toxicologist's conduct fell within the litigation privilege; he performed and communicated the calculations on the request of the district attorney in furtherance of its investigation whether there was probable cause to initiate criminal charges relating to the infant's death, and thus the conduct had some relation to proposed and seriously considered criminal litigation. (Id. at pp. 393394.)

More recently, in Wang v. Heck, supra, 203 Cal.App.4th 677, the appellate court affirmed a summary judgment on grounds the section 47(b) privilege barred a plaintiff motorist's negligence claim against a neurologist who had filled out a medical evaluation form for a patient that was relied upon by the Department of Motor Vehicles (DMV) to reinstate the patient's license. (Id. at pp. 679, 681.) Like plaintiffs in the present case, the plaintiff in Wang sought to avoid the privilege's application by arguing the negligence was not the completion of the DMV medical evaluation form, but the neurologist's treatment of the patient before that time and her failure to warn the patient not to drive. (Id. at pp. 685, 686.) The Court of Appeal rejected that argument. It reasoned none of the plaintiff's causes of action could stand without relying on the neurologist's completion of the DMV medical evaluation form. (Id. at p. 684.) It pointed out that the neurologist was a participant authorized by law to complete the form, and [a]lthough [the neurologist] did not complete the DMV evaluation form for purposes of testifying in judicial proceedings, the form was used in a truth-seeking proceeding[,] that is, it was used in the DMV administrative hearing in order for the DMV hearing officer to determine whether to reinstate the patient's license. (Id. at p. 685.) Further, the form was completed to achieve the object of the DMV hearing: to determine the patient's fitness for driving. (Ibid.) The court stated: [I]t is clear that [the neurologist's] conduct prior to completing the DMV evaluation form was the basis of her communication in completing the form. Although appellants attempt to characterize their claim as medical negligence by failing to warn [the patient] not to drive, the basis of their complaint is [the neurologist's] statement on the DMV medical evaluation form that [the patient] could drive safely. (Id. at p. 686.) In concluding the gravamen of the plaintiff's action was communicative, the Wang court's focus was not on the neurologist's testimonial function at a judicial proceeding, but the use of the neurologist's report in connection with that proceeding. As the court in Wang recognized (id. at pp. 686687), our high court emphasizes the importance of the litigation privilege's absolute protection of access to the courts, even despite its costs: [It] is desirable to create an absolute privilege not because we desire to protect the shady practitioner, but because we do not want the honest one to have to be concerned with [subsequent derivative] actions [Citations.] [W]hen there is a good faith intention to bring a suit, even malicious publications are protected as part of the price paid for affording litigants the utmost freedom of access to the courts. (Action Apartment Assn., Inc. v. City of Santa Monica, supra, 41 Cal.4th at p. 1244.)

Here, as in the above cases, the defendants' DNA test was prepared for the purpose of determining minor's paternity in connection with County's paternity proceeding, and transmitted to and used by County for that purpose. This result does not, as plaintiffs argue, afford[] absolute immunity to DNA paternity testers (Some capitalization omitted.) It protects only those persons or entities conducting tests in connection with or contemplation of litigation within the meaning of the section 47(b) litigation privilege, a result compelled by the breadth of the privilege and its purposes. In reaching our conclusion, we necessarily decline plaintiffs' invitation to adopt the reasoning of the Oklahoma Supreme Court in Berman, supra, 268 P.3d 68.7

Because the conduct relied upon by plaintiffs falls within the section 47(b) litigation privilege, we need not address plaintiffs' arguments concerning whether defendants owed them a duty of care.

III.Patterson's Due Process Argument

Patterson contends he and Falcon were denied their federal due process rights under the Fourteenth Amendment of the U.S. Constitution because they were never served with the summons and complaint pertaining to County's paternity proceeding, and were never apprised of the pendency of the action. This argument fails for several reasons.

First, such a theory was not pleaded in the operative complaint. The sole cause of action in plaintiffs' second amended complaint is general negligence, and thus under the above-summarized summary judgment standards, we are limited to assessing that claim. Plaintiffs did not allege a cause of action for violation of any federal civil rights, which would rest on an entirely different theor[y] of recovery (Laabs v. City of Victorville, supra, 163 Cal.App.4th at p. 1257) and is not fairly encompassed in the second amended complaint. As a consequence, Patterson's due process arguments do not raise triable issues of material fact for a jury on plaintiffs' negligence cause of action.

Second, plaintiffs do not provide record citations to support the assertions made in their opening appellate briefs concerning service of any summons and complaint or their lack of knowledge of County's pending paternity proceeding.8 Third, plaintiffs' opposing summary judgment evidence cited in the trial courtnamely, the declaration of LBG's general manager and laboratory director John Taddie, Ph.D., the request for dismissal of County's 2003 proceeding, and Patterson's stipulation regarding DNA parentage test and order thereondo not provide evidentiary support for plaintiffs' factual statements.

Finally, the summary judgment record establishes that on October 30, 2003, Patterson executed a stipulation to undergo DNA testing, which was filed in County's proceeding on November 5, 2003. While a court must have personal jurisdiction over parties (see County of San Diego v. Gorham, supra, 186 Cal.App.4th at pp. 12261227), it is long settled that a party's consent is a proper basis to confer personal jurisdiction over the party. (See In re Vanessa Q. (2010) 187 Cal.App.4th 128, 135.) In short, Patterson's execution of the stipulation constituted a general appearance in the matter, which operated as a consent to jurisdiction of his person. (See Code Civ. Proc., 410.50, subd. (a); e.g., City of Riverside v. Horspool (2014) 223 Cal.App.4th 670, 679 [general appearance occurs when the defendant takes part in the action or in some manner recognizes the authority of the court to proceed]; Dial 800 v. Fesbinder (2004) 118 Cal.App.4th 32, 52 [same].) Any of these grounds compels us to reject Patterson's due process argument.

IV.Leave to Amend

The Falcons contend that even if the section 47(b) privilege applies, the trial court reversibly erred by denying their oral motion for leave to amend during the summary judgment hearing. They maintain plaintiffs had timely sought leave to amend in 2011 and 2012 to allege additional claims stemming from the respondent's subsequent cover up of its negligence. Patterson similarly claims plaintiffs sought leave to amend in January 2012 to include allegations of negligent acts occurring in 2007 and 2008 that delayed Patterson's 2010 discovery that minor was his daughter. Plaintiffs argue they made every possible effort to timely amend the complaint, and did not unreasonably delay in requesting leave to amend.

A.Legal Principles

A trial court has wide discretion to allow the amendment of pleadings, and generally courts will liberally allow amendments at any stage of the proceeding. (Atkinson v. Elk Corp. (2003) 109 Cal.App.4th 739, 761.) On a motion for summary judgment [w]here the complaint is challenged and the facts indicate that a plaintiff has a good cause of action which is imperfectly pleaded, the trial court should give the plaintiff an opportunity to amend. (Soderberg v. McKinney (1996) 44 Cal.App.4th 1760, 1773.) But if the proposed amendment fails to state a cause of action, it is proper to deny leave to amend. (Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at p. 652.)

Further, unwarranted delay in seeking leave to amend may be considered by the trial court when ruling on a motion for leave to amend (Huff v. Wilkins (2006) 138 Cal.App.4th 732, 746), and appellate courts are less likely to find an abuse of discretion where, for example, the proposed amendment is offered after long unexplained delay or where there is a lack of diligence (Hulsey v. Koehler (1990) 218 Cal.App.3d 1150, 1159.) Thus, when a plaintiff seeks leave to amend his or her complaint only after the defendant has mounted a summary judgment motion directed at the allegations of the unamended complaint, even though the plaintiff has been aware of the facts upon which the amendment is based, [i]t would be patently unfair to allow plaintiffs to defeat [the] summary judgment motion by allowing them to present a moving target unbounded by the pleadings. (Melican v. Regents of University of California (2007) 151 Cal.App.4th 168, 176; but see Laabs v. City of Victorville, supra, 163 Cal.App.4th at p. 1257, fn. 6 [if at the hearing of a summary judgment motion a party finds his pleading inadequate, the court may and should permit him to amend].)

And, under the sham pleading doctrine, the trial court may disregard amendments that omit harmful allegations in the original complaint or add allegations inconsistent with it. (State of California ex rel. Metz v. CCC Information Systems, Inc. (2007) 149 Cal.App.4th 402, 412; Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at pp. 652652 [applying sham pleading doctrine to request for leave to amend in summary judgment context].)

B.Plaintiffs Have Not Demonstrated the Trial Court Abused its Discretion in Denying Leave to Amend

Plaintiffs have not shown the trial court manifestly abused its discretion in denying them leave to amend. They argue they timely sought to allege specific further negligent acts on LabCorp's part in 2007 and 2008 to support an additional claim for negligence or further gross negligence. These acts, which plaintiffs do not further describe in their opening briefs, presumably are defendants' asserted failure to send the parties copies of the test results from additional DNA testing conducted in 2008. But the trial court's decision was not limited to unreasonable delay and plaintiffs do not address the remainder of the court's ruling, which addressed the requirements of Family Code section 7552.59 and the existence of a legal duty of care to notify the parties of the additional test results (see footnote 5, ante). Absent such an analysis, plaintiffs have not shown to this court, as they must (Dey v. Continental Central Credit (2008) 170 Cal.App.4th 721, 731), that the court abused its discretionmade a ruling that exceeds the bounds of reason or is legally incorrect (ibid.)in concluding plaintiffs could not state a viable cause of action for negligence.

Nor do plaintiffs explain on appeal how their new theorythat they suffered damage by the lack of knowledge of the 2008 DNA testingis consistent with the complaint's allegations that plaintiffs did not suspect, nor were they able to discover this error until the Defendant conducted further DNA tests in February 2008 or their admissions in their summary judgment papers that Leslie Falcon discovered the error in February 2008, and Patterson was served with another lawsuit relating to minor's paternity in or around April or May 2008. Plaintiffs may not discard factual allegations of a prior complaint, or avoid them by contradictory averments, in a superseding, amended pleading, and must explain inconsistencies between the prior and proposed pleading. (Oakland Raiders v. National Football League, supra, 131 Cal.App.4th at p. 653; see also Vallejo Development Co. v. Beck Development Co. (1994) 24 Cal.App.4th 929, 946.) The trial court could reasonably conclude that any amendment was inconsistent with plaintiffs' theory of the case, and reject it on that basis.

DISPOSITION

The judgment is affirmed.

FOOTNOTES

1.For example, in their opposing summary judgment separate statements and opening appellate briefs, the Falcons and Patterson assert they had no knowledge of the 2003 paternity proceeding at issue in this matter and Patterson was not served with any summons or complaint. In response to defendants' assertion that the DNA test took place within the confines of the 2003 paternity proceeding, plaintiffs assert: The 2003 paternity test was requested without any knowledge by the parties of said lawsuit, it was not within the confines of any litigation brought or known by the tested parties. [San Diego County Department of Child Support Services (DCSS)] did not serve the tested party any Summons or Complaint. Setting aside the fact that plaintiffs provide no authority for the proposition that a plaintiff must either initiate or have knowledge of pending litigation to defeat the section 47(b) litigation privilege, the evidence cited for this propositionthe declaration of LBG's general manager and laboratory director John Taddie, Ph.D., the request for dismissal of the 2003 proceeding against Patterson, and the November 2003 stipulation regarding DNA parentage test and order thereon executed by Pattersondoes not support these assertions.

2.The September 26, 2003 filing date of County's proceeding is reflected in LabCorp's request for judicial notice of the court file in County's paternity action, as well as in a page from the register of actions attached as an exhibit to counsel's declaration in support of LabCorp's motion for summary judgment. In its order granting summary judgment and judgment thereon, the trial court states that County's paternity proceeding was initiated in September 2003.

3.MICRA applies to any claim of professional negligence against a health care provider. [Citations.] A health care provider is any person licensed or certified pursuant to Division 2 (commencing with Section 500) of the Business and Professions Code (de Mercado v. Superior Court (2007) 148 Cal.App.4th 711, 714.) Code of Civil Procedure section 340.5 provides in part: In an action for injury or death against a health care provider based upon such person's alleged professional negligence, the time for the commencement of action shall be three years after the date of injury or one year after the plaintiff discovers, or through the use of reasonable diligence should have discovered, the injury, whichever occurs first.

4.Plaintiffs also argued defendants' motion should be denied due to defense counsel's unethical misconduct in withholding documents concerning LBG's licensed healthcare provider status and MICRA's one-year limitations period did not apply to plaintiffs' claims because LBG was not a licensed healthcare provider in 2003. Patterson additionally argued there was a factual dispute over whether he knew or reasonably should have known about LBG's 2003 testing error. These points are not pertinent to application of the section 47(b) privilege.

5.The judgment states: Family Code section 7552.5 requires the County to serve on all parties a copy of the results of all genetic tests performed under Section 7552 or 7558 no later than 20 days prior to any hearing in which the genetic test results may be admitted into evidence. As an initial matter, plaintiffs do not identify any hearing that triggered the duty to serve LabCorp's revised conclusion. In addition, the statute imposes the duty to serve on the County. The County hired LBG/LabCorp to provide services in connection with paternity litigation and to assist the court in rendering a judgment in the matter. LabCorp's contractual assumption of the County's obligation under section 7552.5 does not create a duty of care on the part of LabCorp to plaintiffs. (Cf. Felton v. Schaeffer (1991) 229 Cal.App.3d 229.) Likewise, the fact that LabCorp may have contractually agreed to perform the County's obligation to serve plaintiffs with test results does not tend to establish they were intended third party beneficiaries.

6.At oral argument, the appellants repeated an argument raised for the first time in Patterson's reply brief: that LabCorp cannot meet the third and fourth prongs of the litigation privilege because its negligence was in testing the DNA of an unknown man. They contend that as a result, LabCorp's report of test results, even if a communication made in connection with litigation, neither was made to achieve the objects of the litigation nor has any connection or logical relation to the action. (See Action Apartment Assn., Inc. v. City of Santa Monica,supra, 41 Cal.4th at p. 1241; Silberg v. Anderson,supra, 50 Cal.3d at p. 212; see also Rusheen v. Cohen,supra, 37 Cal.4th at p. 1057 [communications with some relation to judicial proceedings are absolutely immune from tort liability].) This argument, if accepted, would make application of the litigation privilege turn not on the connection between the communication and the litigation but on the type or nature of the underlying negligence. We decline to adopt such an unworkable test, which would contradict the law in California that the litigation privilege is to be construed broadly to afford litigants and witnesses [citation] the utmost freedom of access to the courts without fear of being harassed subsequently by derivative tort actions' (Action Apartment, at p. 1241) and that doubts are to be resolved in favor of applying the privilege. (Hawran v. Hixson,supra, 209 Cal.App.4th at p. 283.) LabCorp's DNA testing and communication of results, regardless of the nature of LabCorp's error, was done for the purpose of determining the minor's paternity in connection with County's proceeding, and thus was in furtherance of the objects of, and had some functional relation to, that proceeding. (Action Apartment, at p. 1251 [communication must be in furtherance of the objects of the proceeding and not be extraneous to it]; Rusheen v. Cohen, at p. 1057; Hawran v. Hixson, at pp. 282283 [connection or logical relation for the section 47b privilege must be a functional connection; a necessary or useful step in the litigation process].)

7.The Oklahoma Supreme Court's discussion in Berman,supra, 268 P.3d 68, makes clear that the parameters of Oklahoma's statutory absolute privilege to communications made during or preliminary to a proposed proceeding (12 O.S.2001 1443.1), are different from California's section 47(b) privilege, which applies to all torts except malicious prosecution. (Action Apartment Assn., Inc. v. City of Santa Monica,supra, 41 Cal.4th at pp. 12411242). The Oklahoma privilege bars defamation actions, and had been extended to claims for intentional infliction of emotional distress when based on the same factual allegations as the defamation claim. (Berman, 268 P.3d at p. 71.) The Oklahoma Supreme Court pointed out that the case at hand did not involve a claim for defamation, and further, that the plaintiff's claims were not based on evidence relevant to the paternity and DNA sample of the alleged father, but on evidence that LabCorp tested the DNA of a completely different man, thus the communication was based on the evidence of a stranger to this case. (Ibid.) The court concluded the negligence claim arose not out of the laboratory's communication to the Oklahoma Department of Human Services, but out of its conduct in the performance of its duties. (Id. at pp. 7172.) Observing that the importance of reliable and accurate DNA test results cannot be overstated, the Oklahoma Supreme Court went on to hold, as a matter of first impression, that LabCorp owed a duty to the plaintiff to perform accurate DNA testing for purposes of determining the paternity of her child. (Id. at p. 72.)

8.The Falcons argue: Unbeknownst to appellants at the time they accessed the free paternity test, due to utilizing MediCal for the birthing costs of minor appellant , the County Welfare Department automatically notified, which in turn prompted, the County Department of Child Support Services to initiate a support case for [minor]. This action was done electronically without notice to Falcon or Patterson; neither party knew of or expected any DCSS action to be filed. Neither Falcon nor Patterson initiated any type of case, nor was either party served a Summons or Complaint prior to requesting the free test. Moreover, neither party had any knowledge or notice of any pending case or proceeding prior to accessing the free paternity test from the county. There was no achieving the objects of the litigation as they had no intent to litigate and was [sic] not even aware any litigation existed. There was no purpose or intent to litigate for child support. Patterson makes a largely identical argument. Neither paragraph contains any citation to the record.

9.Family Code section 7552.5 provides in part: A copy of the results of all genetic tests performed under Section 7552 [genetic tests performed by approved laboratory] or 7558 [local child support agency administrative order for genetic testing] shall be served upon all parties, by any method of service authorized under Chapter 5 (commencing with Section 1010) of Title 14 of Part 2 of the Code of Civil Procedure except personal service, no later than 20 days prior to any hearing in which the genetic test results may be admitted into evidence. (Fam.Code, 7552.5, subd. (a).)

O'ROURKE, J.

WE CONCUR:McCONNELL, P.J.IRION, J.

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About Genetics | Understanding Genetics

Thursday, August 4th, 2016

What is a Gene? Look closely at the chromosomes and you'd see that each is made of bundles of looping coils. If you unraveled these coils, you'd have a six-foot long double strand of deoxyribonucleic acid-DNA. A more+ How Do Genes Work? Genes are often called the blueprint for life, because they tell each of your cells what to do and when to do it: be a muscle, make bone, carry nerve signals, and so on. And how do genes orchestrate more+ Why We are Different Biologists use two fancy words to describe the relationship between your genes and your physical traits. The first word is genotype. Your genotype is your genes for a given trait. In most cases, more+ Mutations and Disease DNA is constantly subject to mutations, accidental changes in its code. Mutations can lead to missing or malformed proteins, and that can lead to disease. We all start out our lives with some more+ Genetic Testing Have you ever had your genes tested? Probably not. DNA testing is still pretty limited, although it is becoming more and more common, especially for fetuses and newborns. Many prospective parents, more+ Making Medicines Not long ago, if you were diabetic, the insulin your doctor prescribed would have come from a pig. If you required human growth hormone, it would have come from human cadavers, a source that is more+ New Therapies Many of the worst diseases around are caused by glitches in our genes, and the therapies for these diseases often involve a lifetime of drugs (and their nasty side effects) that help but don't really more+ Ethics The new possibilities created by genetics have brought with them new questions about what is right. An example: genetic testing is, for now, optional. But many medical tests that start out as more+

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About Genetics | Understanding Genetics

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Genetics News – Genetics Science, Genetics Technology, Genetics

Thursday, August 4th, 2016

Last update Continuing debate regarding the validity of the evidence used to create the 2015 Dietary Guidelines, 4 hours ago

Fragile bones are usually an old person's affliction, but sometimes children are born with them. Now, a team of researchers led by UConn professor Ernesto Canalis has shown in mice that a specific gene can cause the disease, ...

A new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinal degeneration in rats with a type of inherited blindness, according to a Cedars-Sinai ...

Researchers at University of California, San Diego School of Medicine and Rady Children's Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but devastating, neurodegenerative condition ...

A new method by researchers in the UK and Belgium makes it possible to study the epigenome and transcriptome of a single cell at the same time. The protocol, published in Nature Methods, helps scientists pinpoint the relationship ...

An analysis funded by the National Eye Institute (NEI), part of the National Institutes of Health, has identified three genes that contribute to the most common type of glaucoma. The study increases the total number of such ...

Tiny vials of recently repaired blood cells are thriving in a Stanford incubator, proof that a powerful new gene-editing technique is fixing errant genes that cause so much human suffering.

Minor variants of flu strains, which are not typically targeted in vaccines, carry a bigger viral punch than previously realized, a team of scientists has found. Its research, which examined samples from the 2009 flu pandemic ...

Researchers have used CRISPR to treat an adult mouse model of Duchenne muscular dystrophy. This marks the first time that CRISPR has successfully treated a genetic disease inside a fully developed living mammal with a strategy ...

Using a new gene-editing technique, a team of scientists from UT Southwestern Medical Center stopped progression of Duchenne muscular dystrophy (DMD) in young mice.

In the first study of its kind, a team of international scientists led by UT Southwestern Medical Center and UCLA researchers have identified a dozen inherited traits related to sleep, wake, and activity cycles that are associated ...

A drug commonly used to treat leukaemia is showing potential as a treatment that could slow the progression of the muscle-wasting condition, Duchenne muscular dystrophy.

(MedicalXpress)A new technique developed by a team of researchers affiliated with a number of facilities in China allows medical practitioners involved in IVF treatment to more easily weed out embryos with genetic defects ...

Chickens that chicken out in unfamiliar surroundings may shed light on anxiety in humans, according to research published in the January issue of the journal Genetics, a publication of the Genetics Society of America.

St. Jude Children's Research Hospital scientists have developed a web application and data set that gives researchers worldwide a powerful interactive tool to advance understanding of the mutations that lead to and fuel pediatric ...

Despite their bad reputations, the vast majority of mutations are not harmful. Even in very rare genetic disorders, only one or two genetic variationsout of tens of thousandsis actually the cause of disease. Distinguishing ...

A review of medical records of patients with genetic variations linked with cardiac disorders found that patients often did not have any symptoms or signs of the conditions, questioning the validity of some genetic variations ...

Molecular biologists at UT Southwestern Medical Center have identified a gene called NORAD that helps maintain the proper number of chromosomes in cells, and that when inactivated, causes the number of chromosomes in a cell ...

The world of epigeneticswhere molecular 'switches' attached to DNA turn genes on and offhas just got bigger with the discovery by a team of scientists from the University of Cambridge of a new type of epigenetic modification.

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character - from aggressive ...

In one of the latest examples of precision medicine, teams of geneticists from nine countries, involving more than 100 scientists, analyzed the genes of more than 33,000 individuals in the hope of finding genetic variations ...

A new technique for pinpointing the exact DNA regions that impact gene regulation lays the groundwork for identifying new drug targets and for developing diagnostics to predict disease risk, A*STAR scientists report.

Scientists have developed an easy-to-use computer program that can quickly analyse bacterial DNA from a patient's infection and predict which antibiotics will work, and which will fail due to drug resistance. The software ...

A butterfly-shaped pigment accumulation in the macula of the eye, which can lead to severe vision loss in some patients, is due to mutations in the alpha-catenin 1 gene (CTNNA1), an international research consortium including ...

Chronic damage to the liver eventually creates a wound that never heals. This condition, called fibrosis, gradually replaces normal liver cellswhich detoxify the food and liquid we consumewith more and more scar tissue ...

Researchers from The University of Queensland have helped identify nearly 1,500 genes associated with ageing that could lead to new health treatments.

The first ever genetic analysis of people with extremely high intelligence has revealed small but important genetic differences between some of the brightest people in the United States and the general population.

In expanding our knowledge of how the brain controls the process of sexual development, researchers at Oregon Healthy & Science University and the University of Pittsburgh have identified for the first time members of an ...

Last December, researchers identified more than 1,000 gene mutations in individuals with autism, but how these mutations increased risk for autism was unclear. Now, UNC School of Medicine researchers are the first to show ...

Researchers from Princeton University have identified genes important for age-related cognitive declines in memory in adult worm neurons, which had not been studied previously. The research, published in the journal Nature, ...

Never before have scientists been able to make scores of simultaneous genetic edits to an organism's genome. But now, in a landmark study by George Church and his team at the Wyss Institute for Biologically Inspired Engineering ...

Mitochondria, the power generators in our cells, are essential for life. When they are under attackfrom poisons, environmental stress or genetic mutationscells wrench these power stations apart, strip out the damaged ...

Researchers at Karolinska Institutet in Stockholm, Sweden, have identified for the first time a cell type in the brain of mice that is integral to attention. By manipulating the activity of this cell type, the scientists ...

A new study from the Monell Center, the U.S. Department of Agriculture (USDA), and collaborating institutions reports a uniquely identifiable odor signature from mouse models of Alzheimer's disease. The odor signature appears ...

Medical researchers at the University of Bristol have uncovered a fundamental mechanism that explains the interaction between brain state and the neural triggers responsible for learning. The discoveries, made by researchers ...

Scientists at The University of Texas at Austin have discovered a mechanism that may explain how the brain can recall nearly all of what happened on a recent afternoonor make a thorough plan for how to spend an upcoming ...

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The Genetic Basics: What are Genes and What do they Do?

Thursday, August 4th, 2016

Chromosomes contain the recipe for making a living thing. They are found in almost every cells nucleus and are made from strands of DNA (deoxyribonucleic acid). Segments of DNA called "genes" are the ingredients. Each gene adds a specific protein to the recipe. Proteins build, regulate and maintain your body. For instance, they build bones, enable muscles to move, control digestion, and keep your heart beating.

Two of these 46 chromosomes determine the sex of a person. A girl inherits two X-chromosomes, one from her mother and one from her father. A boy inherits one X-chromosome from his mother and a small Y-chromosome from his father.

A gene can exist in many different forms, calledalleles. For example, lets say that there is one gene which determines the color of your hair. That one gene may have many forms, or alleles: black hair, brown hair, auburn hair, red hair, blond hair, etc. You inherit one allele for each gene from your mother and one from your father.

Each of the two alleles you inherit for a gene each may be strong ("dominant") or weak ("recessive"). When an allele is dominant, it means that the physical characteristic ("trait") it codes for usually is expressed, or shown, in the living organism. You need only one dominant allele to express a dominant trait. You need two recessivealleles to show a recessive form of a trait. See the heredity diagram for tongue rolling to see how dominant and recessive alleles work.

Tongue Rolling Heredity Diagram

There are several ways the genetic code can be altered. Sometimes genes are deleted or in the wrong place on a chromosome, or pieces of genes are swapped between chromosomes. As a result, the gene may not work or may turn on in the wrong part of the body.

"Point mutations" alter the genetic code by changing the letters in the codons -- the three-symbol genetic words that specify which protein to make. This can change the protein.

Original message: SAM AND TOM ATE THE HAM

Kind of point mutation

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The Genetic Basics: What are Genes and What do they Do?

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Department of Genetics || University of Pennsylvania

Thursday, August 4th, 2016

History of the Department

On the following page is a brief history of the department, along with a video entitled The First 48 Years of the Department of Genetics at the University of Pennsylvania. On the subsequent page there are four additional videos: The Billingham Chairmanship and Transplantation Immunology (Clyde Barker and David Gasser), The Mellman Chairmanship and Cytogenetics (Beverly Emanuel and David Gasser), The Mellman Chairmanship and Maternal/Fetal Medicine (Michael Mennuti and David Gasser), and The Kazazian Chairmanship (Haig Kazazian and David Gasser). Read and view more about the department...

The Department of Genetics hosts a different speaker every Monday of the academic year, with invitees ranging from postdoctoral researchers to prominent scientists presenting a broad array of current, genetics-related research. Our series is cosponsored with the Department of Cell and Developmental Biology, the Epigenetics Program, and the Institute for Regenerative Medicine. Click here to view the schedule.

We are pleased to announce that this year's Tom Kadesch Prize in Genetic Research has been awarded to Derek Oldridge.

Dan Rader, Rebecca Mueller, Derek Oldridge, Abby Huntington, Hannah Kadesch, John Maris

We are pleased to announce the recruitment of Golnaz Vahedi, Ph.D.Golnaz received her Ph.D. in Computational Biology from Texas A&M in 2009, where she studied gene regulatory networks applying Boolean probabilistic modeling and other methods. After developing her interest in regulatory networks controlling gene expression, Golnaz joined Dr. John OSheas laboratory at the National Institutes of Health in 2009. During her postdoctoral training Dr. Vahedi made seminal findings in the area of epigenetic and transcription factor control of cell fate in the immune system. Golnaz will join the Department as a tenure track Assistant Professor on May 1, 2015. Her arrival is expected to further strengthen and expand the Department's capacities in the computational and bioinformatics aspects of immunogenetics.

Yoseph Barash In silico to in vivo splicing analysis using splicing code models. Gazzara MR, Vaquero-Garcia J, Lynch KW, Barash Y. Methods. S1046-2023(13)00444-1, 2013.

AVISPA: a web tool for the prediction and analysis of alternative splicing. Barash Y, Vaquero-Garcia J, Gonzlez-Vallinas J, Xiong HY, Gao W, Lee LJ, Frey BJ. Genome Biol. 14(10):R114, 2013.

Maja Bucan From Mouse to Human: Evolutionary Genomics Analysis of Human Orthologs of Essential Genes. Georgi B, Voight BF, Bucan M PLoS Genet. 2013. 9(5): e1003484.

Genomic View of Bipolar Disorder Revealed by Whole Genome Sequencing in a Genetic Isolate Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bucan M PLoS Genet 10(3): e1004229. doi:10.1371/journal.pgen.1004229, 2014.

Doug Epstein Divergent roles for Wnt/-catenin signaling in epithelial maintenance and breakdown during semicircular canal formation. Rakowiecki S,Epstein DJ. Development 140(8):1730-9, 2013.

Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis. Trowe MO, Zhao L, Weiss AC, Christoffels V,Epstein DJ, Kispert A. Development 140(11):2299-309, 2013.

Arupa Ganguly Parental nutrient intake and risk of retinoblastoma resulting from new germline RB1 mutation. Bunin GR, Li Y, Ganguly A, Meadows AT, Tseng M. Cancer Causes Control. 2013 Feb;24(2):343-55. doi: 10.1007/s10552-012-0120-x. Epub 2012 Dec 8.

A case-control study of paternal occupational exposures and the risk of childhood sporadic bilateral retinoblastoma. Abdolahi A, van Wijngaarden E, McClean MD, Herrick RF, Allen JG, Ganguly A, Bunin GR. Occup Environ Med. 2013 Jun;70(6):372-9. doi: 10.1136/oemed-2012-101062. Epub 2013 Mar 16.

Genomic profile of 320 uveal melanoma cases: chromosome 8p-loss and metastatic outcome. Ewens KG, Kanetsky PA, Richards-Yutz J, Al-Dahmash S, De Luca MC, Bianciotto CG, Shields CL, Ganguly A. Invest Ophthalmol Vis Sci. 2013 Aug 23;54(8):5721-9. doi: 10.1167/iovs.13-12195.

Dominant form of congenital hyperinsulinism maps to HK1 region on 10q. Pinney SE, Ganapathy K, Bradfield J, Stokes D, Sasson A, Mackiewicz K, Boodhansingh K, Hughes N, Becker S, Givler S, Macmullen C, Monos D, Ganguly A, Hakonarson H, Stanley CA. Horm Res Paediatr. 2013;80(1):18-27. doi: 10.1159/000351943. Epub 2013 Jul 13.

Enhanced Sensitivity for Detection of Low-Level Germline Mosaic RB1 Mutations in Sporadic Retinoblastoma Cases Using Deep Semiconductor Sequencing. Chen Z, Moran K, Richards-Yutz J, Toorens E, Gerhart D, Ganguly T, Shields CL, Ganguly A. Hum Mutat. 2013 Nov 26. doi: 10.1002/humu.22488. [Epub ahead of print]

David Gasser Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10. Gasser DL, Winkler CA, Peng M, An P, McKenzie LM, Kirk GD, Shi Y, Xie LX, Marbois BN, Clarke CF and Kopp JB. Am J Physiol Renal Physiol 305(8): F1228-F1238, 2013.

Yugong Ho An -regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus Ho Y, Cooke NE, Liebhaber SA. Mol Cell Biol. In Press.

Stephen Liebhaber An -regulatory pathway establishes the definitive chromatin conformation at the Pit-1 locus Ho Y, Cooke NE, Liebhaber SA. Mol Cell Biol. In Press.

TissueSpecific CTCF Occupancy andBoundary Function at the Human Growth HormoneLocus Tsai, Y-C, Cooke, NE, and Liebhaber, SA Nucleic Acids Research. 42: 4906-21., 2014.

Specific enrichment of the RNA-bindingproteins PCBP1 and PCBP2 in chief cells of the murinegastric mucosa Ghanem,LR, Chatterji, P, and Liebhaber, SA Gene Expression Patterns. 14:78-87, 2014. Autonomous Actions of theHumanGrowth Hormone Long-Range Enhancer Yoo, EJ, Brown, CD., Tsai, Y-C, Cooke, NE, and Liebhaber, SA Nucleic Acids Research. 2015.

Julia I-Ju Leu Structural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocket. Leu JI, Zhang P, Murphy ME, Marmorstein R, George DL ACS Chem Biol. 9(11): 2508-16, 2014.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R PLoS One. 9(7): e103518, 2014.

Meera Sundaram A cell non-autonomous role for Ras signaling in C. elegans neuroblast delamination Parry, J. M. and Sundaram, M. V. Development 141: 4279-4284, 2014.

Sarah Tishkoff Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent. Aminkeng F, Ross CJ, Rassekh SR, Brunham LR, Sistonen J, Dube MP, Ibrahim M, Nyambo TB, Omar SA, Froment A, Bodo JM, Tishkoff S, Carleton BC, Hayden MR. The Pharmacogenomics Journal J. doi: 10.1038/tpj. 2013.

Comparison Between Southern Blots and qPCR Analysis of Leukocyte Telomere Length in the Health ABC Study. Elbers CC, Garcia ME, Kimura M, Cummings SR, Nalls MA, Newman AB, Park V, Sanders JL, Tranah GJ, Tishkoff SA, Harris TB, Aviv A. The journals of gerontology. Series A, Biological sciences and medical sciences, published online ahead of print, 2013.

Patterns of nucleotide and haplotype diversity at ICAM-1 across global human populations with varying levels of malaria exposure. Gomez F, Tomas G, Ko WY, Ranciaro A, Froment A,Ibrahim M, Lema G, Nyambo TB, Omar SA, Wambebe C, Hirbo JB, Rocha J, Tishkoff SA. Human Genetics 132(9): 987-99, 2013.

Identifying Darwinian selection acting on different human APOL1 variants among diverse African populations. Ko WY, Rajan P, Gomez F,Scheinfeldt L, An P, Winkler CA, Froment A, Nyambo TB, Omar SA, Wambebe C, Ranciaro A, Hirbo JB, Tishkoff SA. American Journal of Human Genetics 93(1): 54-66, 2013.

Great ape genetic diversity and population history. Prado-Martinez J, Sudmant PH, Kidd JM, Li H, Kelley JL, Lorente-Galdos B, Veeramah KR, Woerner AE, O'Connor TD, Santpere G, Cagan A, Theunert C, Casals F, Laayouni H, Munch K, Hobolth A, Halager AE, Malig M, Hernandez-Rodriguez J, Hernando-Herraez I, Prfer K, Pybus M, Johnstone L, Lachmann M, Alkan C, Twigg D, Petit N, Baker C, Hormozdiari F, Fernandez-Callejo M, Dabad M, Wilson ML, Stevison L, Camprub C, Carvalho T, Ruiz-Herrera A, Vives L, Mele M, Abello T, Kondova I, Bontrop RE, Pusey A, Lankester F, Kiyang JA, Bergl RA, Lonsdorf E, Myers S, Ventura M, Gagneux P, Comas D, Siegismund H, Blanc J, Agueda-Calpena L, Gut M, Fulton L, Tishkoff SA, Mullikin JC, Wilson RK, Gut IG, Gonder MK, Ryder OA, Hahn BH, Navarro A, Akey JM, Bertranpetit J, Reich D, Mailund T, Schierup MH, Hvilsom C, Andrs AM, Wall JD, Bustamante CD, Hammer MF, Eichler EE, Marques-Bonet T. Nature. 499(7459):471-5. 2013. Origin and differential selection of allelic variation at TAS2R16 associated with salicin bitter taste sensitivity in Africa. Campbell MC, Ranciaro A, Zinshteyn D, Rawlings-Goss R, Hirbo JB, Thompson SI, Woldemeskel D, Froment A, Rucker JB, Omar SA, Bodo J-M, Nyambo T, Belay G, Drayna D, Breslin PAS, Tishkoff SA. Molecular Biology and Evolution, Advanced online publication. 2013.

Zhaolan (Joe) Zhou Cellular origins of auditory event-related potential deficits in Rett syndrome Goffin D, Brodkin ES, Blendy JA, Siegel SJ and Zhou Z Nature Neuroscience. 17(6): 804-806, 2014.

Yoseph Barash has been awarded an R01 from the National Institute on Aging. Title: Modeling Splicing in normal tissues and neurodegenerative disease R01 AG046544-01A1

Joe Zhou has been awarded an R01 from the NINDS. Title: Understanding the Pathogenic Mechanisms of Rett Syndrome R01-NS081054

Donna George has been awarded a P01 from the NCI. Title: Targeted Therapies in Melanoma 2P01 CA114046-06

John Murray has been awarded an R01 from the NIH. Title: Mechanisms integrating lineage history with fate specification in C. elegans 1R01GM105676-01A1

Casey Brown has been awarded an R01 from the NIMH. Title: Identification and validation of cell specific eQTLs by Bayesian modeling 1-R01-MH101822-01

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Human Genetics – The University of Chicago Medicine

Thursday, August 4th, 2016

The Department of Human Genetics offers comprehensive clinical services for the diagnosis and management of genetic disorders, in addition to state-of-the-art laboratory diagnostics.

Two medical geneticists and three genetic counselors participate in pediatric and general genetics, neurogenetics, and craniofacial clinics, as well as provide consultation services. Areas of specialization and research interests include evaluation and counseling for brain malformations, metabolic conditions, and mental retardation of unknown origin.

Our cytogenetics laboratory offers routine chromosome analysis and FISH analysis for prenatal diagnosis, as well as congenital and reproductive disorders. Cancer cytogenetic services are available through the Department of Medicine, Section of Hematology and Oncology.

The molecular genetics laboratory provides DNA analysis for a variety of conditions affecting adults and children, as well as prenatal diagnosis. Molecular genetic assays for infectious diseases and somatic abnormalities associated with cancers are available through our Department of Pathology.

Specialty services offered in our laboratories include testing for telomere rearrangements, imprinting disorders, brain malformations, and customized diagnostics for families affected with rare, or orphan, diseases.

The clinical genetics laboratories are CLIA-certified and CAP-accredited, and will facilitate genetic research for University of Chicago faculty by providing core services (cell culture, DNA isolation, sequencing and genotyping, and patient specimen storage) in a quality-controlled setting.

Our clinical and laboratory genetics staff also contribute to the prenatal and cancer risk clinics that are provided through the obstetrics & gynecology and medicine departments, respectively.

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Genetics flashcards | Quizlet

Thursday, August 4th, 2016

mendelian genetics

The scientific study of heredity

Augustinian monk and botanist whose experiments in breeding garden peas led to his eventual recognition as founder of the science of genetics (1822-1884)

specific physical characteristic that varies from one individual to another

section of DNA that codes for a specific trait

a genotype with two different alleles.

different forms of a gene

Mendel's second conclusion, which states that some alleles are dominant and others are recessive

specialized cell involved in sexual reproduction

process in sexual reproduction in which male and female reproductive cells join to form a new cell

term used to describe organisms that produce offspring identical to themselves if allowed to self-pollinate

parental generation, the first two individuals that mate in a genetic cross

the first generation of offspring obtained from an experimental cross of two organisms

the second generation of offspring, obtained from an experimental cross of two organisms; the offspring of the F1 generation

The likelihood that a particular event will occur

a chart that shows all the possible combinations of alleles that can result from a genetic cross

genetic makeup of an organism

The physical traits that appear in an individual as a result of its gentic make up. What an organism looks like.

Scientific term for having two different alleles for a trait

Scientific term for having two identical alleles for a trait

Scientific term for having two dominant alleles for a trait

Scientific term for having two recessive alleles for a trait

creates a blended phenotype; one allele is not completely dominant over the other

situation in which both alleles of a gene contribute to the phenotype of the organism

(genetics) cell division that produces reproductive cells in sexually reproducing organisms

term used to refer to a cell that contains a complete set of chromosomes

an organism or cell having only a half set of chromosomes

pair of identical chromosomes

a genotype with two of the same alleles.

the study of genetics

SS and Ss

QQ, Qq, qq

3 smooth face: 1 face spikes

tongue rolling

3 tongue rolling:1 cannot roll tongue

Example:

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Overview | Department of Genetics | Albert Einstein College …

Thursday, August 4th, 2016

Welcome to the Department of Genetics, one of the ten basic science departments within the Sue Golding Graduate Division of the Albert Einstein College of Medicine.The Department is on an exciting trajectory of renewed growth and development after having been without a chair for the last several years. Based on its academic excellence in areas varying from genetics of nematode behavior to the molecular basis of human disease, the Department is poised to enter new, exciting areas of genetics research made possible by revolutionary changes in our tools to study genes and their function in an integrated manner in various organisms.

By taking an integrated approach, both within the Department and across other Einstein departments, with a strong interdisciplinary focus and our emphasis on clinical applicability, the Department of Genetics is becoming a driver of basic and translational research at Einstein.

Two new divisions, the Division of Translational Genetics and the Division of Computational Genetics, directed by Bernice Morrow and John Greally, respectively, were added to a Division of Molecular Genetics under the leadership of Nick Baker. Our laboratory space in the Ullmann building is being renovated and beautiful new facilities in the Price Center have become available. New faculty are currently being recruited with a focus on human disease genetics with ample attention to strengthening the Departments technology base.

Indeed, two next-generation sequencers will come on line soon and new faculty, i.e., technology innovators, are actively being recruited to develop new genomics tools to accelerate Einsteins basic and clinical research. Our already strong suite of core genomics technology services will be re-organized and expanded, providing our researchers with the cutting-edge tools for making new, fundamental discoveries in genetics. Increased emphasis on epigenetic regulation has led to a new Center for Epigenomics, directed by John Greally, which focuses on understanding how the normal epigenome becomes dysregulated in human disease. By taking an integrated approach, both within the Department and across other departments, with a strong interdisciplinary focus and are-emphasis on clinical applicability, the Department of Genetics is becoming a driver of basic and translational research at Einstein.

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Articles about Genetics – latimes

Thursday, August 4th, 2016

SCIENCE

March 13, 2014 | By Melissa Healy, This post has been corrected. Please see below for details.

When the Food & Drug Administration last November ordered the Mountain View, Calif.-based firm 23andMe to stop marketing its health-related genetic test kit to consumers, the ensuing debate took on a "rage against the machine" tenor. Entrepreneurs, patients' rights advocates and genetics geeks across the country argued that the plodding, risk-averse regulators of the FDA had neither the right nor the expertise to insert themselves between people wishing to own whatever mysteries their genes contained, and a company that promised to deliver such information.

NEWS

December 20, 2012 | By Melissa Healy

Will Adam Lanza's genes help answer the incomprehensible? Connecticut's chief medical examiner, Dr. H. Wayne Carver II, has said that he has asked a geneticist at the University of Connecticut to contribute to the investigation of Lanza , the 20-year-old who last week shot 20 children and six adults at a school in Newtown, Conn., and then turned the gun on himself as police arrived. Hope of peering into Lanza's state of mind as he prepared his final act has been dashed by the assailant's apparent destruction of his computer's hard drive.

CALIFORNIA | LOCAL

March 24, 2010 | By Thomas H. Maugh II

Dr. Leena Peltonen, an unusually prolific genetics researcher whose team discovered mutated genes responsible for 15 inherited diseases and who established the department of human genetics at UCLA, died of cancer March 11 at her home in Finland. She was 57. Her "contribution to understanding the genetics of human disease has been a lifelong commitment and is simply outstanding," said Allan Bradley, director of the Wellcome Trust Sanger Institute in England, where Peltonen ended her career.

SCIENCE

August 7, 2012 | By Eryn Brown, Los Angeles Times

North African Jews are more closely related to Jews from other parts of the world than they are to most of their non-Jewish neighbors in North Africa, a study has found. Furthermore, their DNA carries a record of their migrations over the centuries: Some bits trace back to the Middle Eastern peoples thought to have migrated to North Africa more than 2,000 years ago, while other bits are linked to Spanish and Portuguese Jews who fled to North Africa after their expulsion from the Iberian Peninsula in the late 15th century, the study's authors said.

SCIENCE

July 21, 2007 | From Times Staff and Wire Reports

Scientists have linked certain genes to restless legs syndrome, suggesting the twitching condition is biologically based and not an imaginary disorder. Research in the New England Journal of Medicine, linked a gene variation to nighttime leg-twitching. It involved people in Iceland and the United States. A second study in Nature Genetics identified the same variation and two others in Germans and Canadians with the syndrome.

BUSINESS

December 15, 2013 | MICHAEL HILTZIK

Cutting-edge companies often walk a tightrope between regulators trying to keep their technologies under control and marketers trying to push them out to consumers as fast as possible. That's where a Silicon Valley company named 23andMe is today. The Mountain View, Calif., firm has been hawking genetic tests for you to take at home. You spit into a receptacle and ship your saliva back to the company so it can analyze your DNA for a mere $99. Eventually you get a readout detailing your genetic susceptibility to hundreds of diseases.

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Annual Review of Genetics – Home

Thursday, August 4th, 2016

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Genetics for Kids – Science Games and Videos

Thursday, August 4th, 2016

Grade: 6 - 12

Learn about the basics of cells, chromosomes, and the genes contained in our DNA.

4:25

Grade: 6 - 12

Learn about the variations in our DNA called SNPs, and how they can help us understand relationships between people.

1:50

Grade: 6 - 12

Find out how chromosomes and genes are passed down from parent to child.

4:15

Grade: 6 - 12

Discover how our observable traits, also called phenotypes, are the result of interactions between our genes and environment.

2:05

Grade: 6 - 12

DNA and genetics for kids - Learn about genetics and the structure of DNA.

6:30

Grade: 6 - 12

6:35

Grade: 6 - 12

A lesson on genetics, it defines the central principle of biology and explains how DNA works to translate proteins. It compares mitosis and meiosis, and also explains how Mendelian genetics differs from the current understanding of genetics.

6:40

Grade: 6 - 12

The lesson reviews the major concepts in genetics - DNA and RNA, mitosis and meiosis, haploid and diploid cells, Mendelian and chromosomal genetics.

19:40

Grade: 6 - 12

The presentation describes the molecular structure of DNA.

10:30

Grade: 6 - 12

The lesson explains simple Mendelian genetics. It begins with a brief introduction of Gregor Mendel and his laws of segregation and independent assortment. Also presented are a number of simple genetics problems along with their answers.

16:00

Grade: 6 - 12

A presentation about Gregor Mendel and his immense contribution to the study of genetics.

4:55

Grade: 6 - 12

Learn about heredity. Heredity is the transmission of traits and characteristics from parent to offsprings through genes.

3:10

Grade: 6 - 12

The presentation explains how genome works and how it affects our lives.

3:35

Grade: 6 - 12

Since 'Jurassic Park', everyone's waiting for a cloned dino. Well, how about a woolly mammoth? It's not that easy; learn about the recent discoveries that are helping this process.

3:00

Grade: 8 - 12

Learn about the DNA replication process, the enzymes that are involved, and how the amazing process that makes life possible works!

8:00

Grade: 8 - 12

A lesson on genetics, DNA and laws of inheritance.

10:00

Grade: 8 - 12

10:00

Grade: 8 - 12

10:00

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The Genetics of Cancer – National Cancer Institute

Thursday, August 4th, 2016

Genetic Changes and Cancer

Cancer is a genetic diseasethat is, cancer is caused by certain changes to genes that control the way our cells function, especially how they grow and divide. These changes include mutations in the DNA that makes up our genes.

Genetic changes that increase cancer risk can be inherited from our parents if the changes are present in germ cells, which are the reproductive cells of the body (eggs and sperm). Such changes, called germline changes, are found in every cell of the offspring.

Cancer-causing genetic changes can also be acquired during ones lifetime, as the result of errors that occur as cells divide during a persons lifetime or exposure to substances, such as certain chemicals in tobacco smoke, and radiation, such as ultraviolet rays from the sun, that damage DNA.

Genetic changes that occur after conception are called somatic (or acquired) changes. They can arise at any time during a persons life. The number of cells in the body that carry such changes depends on when the changes occur during a persons lifetime.

In general, cancer cells have more genetic changes than normal cells. But each persons cancer has a unique combination of genetic alterations. Some of these changes may be the result of cancer, rather than the cause. As the cancer continues to grow, additional changes will occur. Even within the same tumor, cancer cells may have different genetic changes.

Inherited genetic mutations play a major role in about 5 to 10 percent of all cancers. Researchers have associated mutations in specific genes with more than 50 hereditary cancer syndromes, which are disorders that may predispose individuals to developing certain cancers.

Genetic tests can tell whether a person from a family that shows signs of such a syndrome has one of these mutations. These tests can also show whether family members without obvious disease have inherited the same mutation as a family member who carries a cancer-associated mutation. (For more information, see this overview of genetic testing for hereditary cancer syndromes.)

Many experts recommend that genetic testing for cancer risk be considered when someone has a personal or family history that suggests an inherited cancer risk condition, as long as the test results can be adequately interpreted (that is, they can clearly tell whether a specific genetic change is present or absent) and when the results provide information that will help guide a persons future medical care.

Cancers that are not caused by inherited genetic mutations can sometimes appear to run in families. For example, a shared environment or lifestyle, such as tobacco use, can cause similar cancers to develop among family members. However, certain patterns in a familysuch as the types of cancer that develop, other non-cancer conditions that are seen, and the ages at which cancer developsmay suggest the presence of a hereditary cancer syndrome.

Even if a cancer-predisposing mutation is present in a family, not everyone who inherits the mutation will necessarily develop cancer. Several factors influence the outcome in a given person with the mutation, including the pattern of inheritance of the cancer syndrome.

Here are examples of genes that can play a role in hereditary cancer syndromes.

For more genes that can play a role in hereditary cancer syndromes, see Genetic Testing for Hereditary Cancer Syndromes.

Genetic tests are usually requested by a persons doctor or other health care provider. Genetic counseling can help people consider the risks, benefits, and limitations of genetic testing in their particular situations.

The results of genetic tests can be positive, negative, or uncertain. A genetic counselor, doctor, or other health care professional trained in genetics can help an individual or family understand their test results. These professionals can also help explain the incidental findings that a test may yield, such as a genetic risk factor for a disease that is unrelated to the reason for administering the test. And they can clarify the implications of test results for other family members.

Medical test results are normally included in a persons medical records, particularly if a doctor or other health care provider has ordered the test or has been consulted about the test results. Therefore, people considering genetic testing should understand that their results may become known to other people or organizations that have legitimate, legal access to their medical records, such as their insurance company or employer, if their employer provides the patients health insurance as a benefit.

However, legal protections are in place to prevent genetic discrimination. The Genetic Information Nondiscrimination Act of 2008 is a federal law that prohibits discrimination based on genetic information in determining health insurance eligibility or rates and suitability for employment. In addition, because a persons genetic information is considered health information, it is covered by the Privacy Rule of the Health Information Portability and Accountability Act of 1996.

Until recently, most genetic testing for cancer focused on testing for individual inherited mutations. But, as more efficient and cheaper DNA sequencing technologies have become available, sequencing of an individuals entire genome or the DNA of an individuals tumor is becoming more common.

Clinical DNA sequencing can be useful in detecting many genetic mutations at one time. Targeted multiple-gene panels test for many inherited mutations or somatic mutations at the same time. These panels can include different genes and be tailored to individual tumor types. Targeted gene panels limit the data to be analyzed and include only known genes, which makes the interpretation more straightforward than in broader approaches that assess the whole genome (or tumor genome) or significant parts of it. Multiple-gene panel tests are becoming increasingly common in genetic testing for hereditary cancer syndromes.

Tumor sequencing can identify somatic mutations that may be driving the growth of particular cancers. It can also help doctors sort out which therapies may work best against a particular tumor. For instance, patients whose lung tumors harbor certain mutations may benefit from drugs that target these particular changes.

Testing tumor DNA may reveal a mutation that has not previously been found in that tumor type. But if that mutation occurs in another tumor type and a targeted therapy has been developed for the alteration, the treatment may be effective in the new tumor type as well.

Tumor sequencing can also identify germline mutations. Indeed, in some cases, the genetic testing of tumors has shown that a patients cancer could be associated with a hereditary cancer syndrome that the family was not aware of.

As with testing for specific mutations in hereditary cancer syndromes, clinical DNA sequencing has implications that patients need to consider. For example, they may learn incidentally about the presence of germline mutations that may cause other diseases, in them or in their family members.

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Genetics – BIO410 – University of Phoenix

Thursday, August 4th, 2016

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This course presents students with the concepts of genetics. Students will examine mitosis and meiosis, chromosomes, DNA structure, gene mutation, and genome dynamics.

This undergraduate-level course is 5 weeks. This course is available to take individually or as part of a degree or certificate program. To enroll, speak with an Enrollment Representative.

The University of Phoenix reserves the right to modify courses.

While widely available, not all programs are available in all locations or in both online and on-campus formats. Please check with a University Enrollment Representative.

Transferability of credit is at the discretion of the receiving institution. It is the students responsibility to confirm whether or not credits earned at University of Phoenix will be accepted by another institution of the students choice.

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UAB – SOM – Department of Genetics – UASOM Department of …

Thursday, August 4th, 2016

Overview

The University of Alabama at Birmingham Genetics Training Program is accredited by the American Board of Medical Genetics to provide training in clinical biochemical genetics, clinical molecular genetics, and clinical cytogenetics. Fellowship programs are each two to three years in length.

Application Eligibility

Trainees must be eligible to sit for the ABMG examination in the clinical laboratory specialty to which they are applying upon completion of the program. A complete list of eligibility criteria is available on theABMG Web site.

Trainees who have received doctoral degrees outside the U.S., Puerto Rico, or Canada must comply with additional requirements, which are outlined at theABMG Web site. Please note: Trainees who hold an M.D. or equivalent from a foreign country must have either a standard certificate from the ECFMG or have passed the Test of Spoken English (TSE).

Application Process

Applicants interested in applying to the ABMG Fellowship Program should provide the following:

NOTE: Please note that our next opening will be in July 2017. We will accept applications for the 2017 cycle from March 15th -September 15th, 2016. We will NOT be accepting any applications for the 2016 cycle.

Applications will not be considered complete until all information is received. Applications are reviewed by the program director.

Application deadline : September 15 Eligible applicant interview : October Final decision: End of November Fellowship start date: July 1st

Contact

Shaila P. Handattu PhD, PMP Program Director II University of Alabama at Birmingham Department of Genetics Kaul 230, 720 20th Street South Birmingham, AL 35294 Phone: (205) 934-9417 Fax: (205) 934-9488 E-mail: hande@uab.edu

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What kind of jobs can I get with a Genetics major? | Texas A …

Thursday, August 4th, 2016

GENETICS

A major in genetics can lead to careers in fields as diverse as agriculture, criminology, and communication. Below is a list, by no means comprehensive, of careers geneticists pursue. Browse through this list to get an overview of each kind of career.

Common careers

Geneticists conduct research in various fields of science, ranging from agriculture to wildlife biology. The list below describes some areas of research, listed in alphabetical order, in these fields.

Education: The minimum educational requirement to be hired as a plant geneticist is a bachelors degree in biology, genetics, agriculture, or a closely related field. Since genetics draws heavily on mathematics, statistics, and biochemistry, a solid foundation in these subjects is also important.

The minimal educational requirement for a plant genetics research assistant position is a bachelors degree in genetics, agronomy, crop science, or a related degree. The skill set required of a research assistant varies according to the research project and can include experience in working with certain crops or knowledge of particular plant diseases, ability to maintain greenhouse plants and database inventory records, and ability to analyze phenotypic and genotypic data and perform molecular biology techniques such as PCR and Western blotting.

A masters and PhD degree will strongly increase opportunities to conduct independent research.

Places of employment: Plant geneticists can find work in federal, state, or local government laboratories; agricultural experiment stations; botanical gardens, arboretums, national parks; university laboratories; or private agricultural companies.

Useful links:

Careers in genetics and the biosciences: http://www.ornl.gov/sci/techresources/Human_Genome/education/careers-6new.pdf

Genetics and plant biology career snapshot: http://nature.berkeley.edu/site/forms/oisa/gpb_career_snapshot.pdf

How can genetic information be useful in natural resource management? http://www.grcp.ucdavis.edu/projects/GeneticFactsheets/Vol_02_print.pdf

Education and Places of employment: A certificate or an associates degree in medical or veterinary technology is the minimum qualification to work as a technician in an animal genetics lab. A bachelors degree in science (for example, genetics, biology, biochemistry, or poultry science) followed by a masters degree in an area of specialization is likely to increase job prospects. If youre interested in bioinformatics, besides biology, courses in math, statistics, and computer sciences are essential. A PhD is usually required for teaching at the college level or for conducting independent research.

Places of employment: Animal geneticists can find work in animal biotechnology companies, breeding companies, livestock genetics industries, zoos, non-profit organizations involved in the conservation of endangered species, hatcheries, universities, and the federal government.

Useful links:

Texas A&M University Animal Genetics Laboratory: http://catdnatest.org/TexasAM.html

Texas A&M University Equine Embryo Laboratory: http://vetmed.tamu.edu/equine-embryo-laboratory

Animal geneticist. Knowing genes. Improving animals: http://www.agriculture.purdue.edu/usda/careers/pdfs/AnimalGeneticist.pdf

Education: The minimum qualification required to work as a research technician or a research assistant in a laboratory conducting genetics-based entomological research is a bachelors degree in entomology, genetics, molecular biology, or a related field. In addition to a strong science background, some research technician positions require experience in DNA-based techniques and in maintaining insectaries as well as computer skills to collect and analyze data. Masters and PhD degrees increase opportunities for research.

Places of employment: These include government agencies, pest control and agrochemical companies, nature centers, and universities.

Education: For research positions, the minimum qualification is a bachelors degree in genetics, biology, environmental science, ecology, botany, zoology, or a related field. Masters and PhD degrees increase opportunities for research.

Places of employment: These include federal agencies (for example, the US Fish and Wildlife Service, USDA Animal and Plant Health Inspection Service), private and non-profit conservation and environmental organizations, nature and forest preserves, zoos, botanical gardens, and universities.

Useful links:

Conservation geneticist. A variety of career directions: http://medicine.jrank.org/pages/2097/Conservation-Geneticist-Variety-Career-Directions.html

Conservation genetics. The University of Utah. http://learn.genetics.utah.edu/archive/conservation/index.html

Education: Refer to the Forensics major section

Places of employment: Refer to the Forensics major section

Useful links:

National Center for Forensic Science: http://ncfs.ucf.edu/index.html

Wildlife forensics: http://www.enotes.com/forensic-science/wildlife-forensics

DNA forensics: http://www.ornl.gov/sci/techresources/Human_Genome/elsi/forensics.shtml

Forensic genomics: http://www.forensicgenomics.nl//index.php?parentContentID=&contentID=8ba4ff43-d52c-4b56-a975-1ecedcb96ee4

Research careers in forensics: http://sciencecareers.sciencemag.org/career_development/previous_issues/articles/2006_09_15/research_careers_in_forensics/

Education: A strong foundation in mathematics and science is good preparation for research in human genetics. Masters and PhD degrees increase opportunities for research. An MD-PhD degree, which provides training in both clinical and basic science, increases opportunities to conduct translational research.

Places of employment: These include medical centers, research institutes, hospitals, and biotech companies.

Useful links:

The future of genetics. Career opportunities for young scientists. http://sciencecareers.sciencemag.org/career_magazine/previous_issues/articles/2006_09_29/noDOI.6711002142138644027

National Human Genome Research Institute Research Investigators: http://www.genome.gov/10000297

Microbial genetics involves studying the genetics of microbes such as bacteria and fungi. Listed below are some areas of research.

Education: An advanced degree in science may not be required for entry-level positions as a research assistant in a microbial genetics laboratory. However, a masters degree in genetics, genomics, or microbiology followed by a PhD increase opportunities for research.

Places of employment: These include government agencies, medical centers, universities, pharmaceutical companies, the agricultural industry, and diagnostic laboratories.

Useful links:

Bacterial geneticist/genomicist: http://www.genome.gov/GenomicCareers/career.cfm?id=1

(Also, explore areas of research within the fields of bioinformatics and computational genetics as they overlap with those in the field of statistical genetics.)

Education: Training to become a statistical geneticist can begin with an undergraduate degree in mathematics, statistics, physics, or computer science followed by a graduate degree in statistical genetics. It is also possible to begin with an undergraduate degree in biology or genetics followed by courses in statistics in graduate school. The key is to have a strong background in both biology and mathematics. Computer programming skills are an asset.

Places of employment: These include biostatistics and epidemiology departments in universities; state or federal genetic, genomic, or health centers (for example, the National Institutes of Health (NIH)); and biotechnology, pharmaceutical, and pharmacogenomic companies.

Useful links:

Count on it (Article from naturejobs.com on skills required and employment opportunities in statistical genetics): http://www.nature.com/naturejobs/2007/070222/full/nj7130-946a.html

Carolina center for genome sciences, Bioinformatics and computational biology training program: http://genomics.unc.edu/training/bcb.html

Statistical genetics short coursefeaturing Mendel software: http://genomics.unc.edu/events/statgen/ (This course was held in 2010, but check Web site for updates.)

University of Washington, Summer Institute in Statistical Genetics: http://www.biostat.washington.edu/suminst/sisg/general

University of Michigan, Center for statistical genetics: http://csg.sph.umich.edu/index.php (Examples of job descriptions within the field of statistical genetics)

Genetic Analysis Workshop. Southwest Foundation for Biomedical Research: http://www.gaworkshop.org/index.html

A review on the field of statistical genetics: http://schizophreniabulletin.oxfordjournals.org/content/33/1/95.abstract

Statistical geneticist: http://medicine.jrank.org/pages/2857/Statistical-Geneticist.html

Nature Reviews Genetics. Computational genetics: http://www.nature.com/nrg/focus/compgen/index.html (Collection of papers on computational genetics)

Education: A bachelors degree in genetics, biology, biomedical science or a related field is the minimum qualification for entry-level positions as a research technician in the field of veterinary medicine. Masters and PhD degrees lead to opportunities to conduct independent research.

Places of employment: These include veterinary genetic laboratories, private companies that offer veterinary genetic services, universities, animal breeders, biotechnology companies, and medical research institutes.

Education: For research positions, the minimum qualification is a bachelors degree in wildlife biology, zoology, or a related field. Masters and PhD degrees increase opportunities for research.

Places of employment: Federal agencies (for example, the US Fish and Wildlife Service, USDA Animal and Plant Health Inspection Service), private and non-profit conservation and environmental organizations, nature and forest preserves, zoos, and wildlife genetics laboratories in universities.

Useful links:

Conservation genetics: http://learn.genetics.utah.edu/archive/conservation/

Clinical geneticists are doctors who work with patients to identify, diagnose, and treat genetic diseases. They may also conduct research on genetic disorders; teach interns and residents about the diagnosis and management of clinical genetic disorders; and have administrative roles, for example, planning and coordinating large-scale screening programs for genetic diseases.

Education: After obtaining a medical degree, clinical geneticists complete 2 years of residency in medical disciplines approved by the Accreditation Council for Graduate Medical Education (ACGME), followed by a 2-year ACMGE-accredited residency in clinical genetics. They may then obtain certification (which involves passing an examination administered by the American Board of Medical Genetics) in one of four specialties: clinical genetics, clinical biochemical genetics, clinical cytogenetics, and clinical molecular genetics. (Clinical biochemical geneticists, cytogeneticists, and molecular geneticists may have either an MD or a PhD degree in genetics or a related biological science.)

Places of employment: Clinical geneticists work in research centers, hospitals, or medical centers or have private practices.

Useful links:

American Board of Medical Genetics. Training options: http://www.abmg.org/pages/training_options.shtml

American Board of Medical Genetics. Specialties of genetics. http://www.abmg.org/pages/training_specialties.shtml

Clinical geneticist. http://www.bookrags.com/research/clinical-geneticist-gen-01/

American Board of Medical Specialties: http://www.abms.org/who_we_help/consumers/about_physician_specialties/medical.aspx

Careers in genetics. Genetics Society of America: http://www.genetics-gsa.org/pages/careers_fisher.shtml

Clinical laboratory technologists or scientists perform chemical, biological, hematological, immunologic, microscopic, and bacteriological tests. For example, they may examine body fluids for the presence of bacteria, determine the concentration of compounds such as blood glucose, and prepare blood samples for transfusion. They not only perform laboratory procedures, but interpret test results, conduct research, develop new test methods, perform quality control, and supervise clinical laboratory technicians.

Technologists in large laboratories specialize in a particular field of laboratory science. For example, cytotechnologists examine cells for chromosomal abnormalities.

Education: The minimal educational requirement to qualify for an entry-level position as a clinical laboratory technologist is generally a bachelors degree with a major in medical technology or one of the life sciences.

Bachelors degree programs in medical technology include courses in chemistry, biology, microbiology, math, statistics, management, business, computers as well as specialized clinical laboratory science courses. These programs are offered by universities and academic medical centers, and graduates with a Bachelor of Science degree are eligible to apply to them.

To find a clinical laboratory scientist/medical technologist program accredited by the National Accrediting Agency for Clinical Laboratory Sciences (NAACLS), refer to http://www.naacls.org/search/programs.asp.

Graduates of a clinical laboratory science program are eligible for national certification as a clinical laboratory scientist/medical technician by passing an exam administered by the American Society for Clinical Pathology Board of Certification. (For a listing of the certifications and qualifications offered by the board, visit http://www.ascp.org/boc.)

For information on the eligibility criteria for these examinations, visit http://www.ascp.org/FunctionalNavigation/certification/GetCertified/TechnicianCertification.aspx.

Certification and accreditation can also be obtained through the National Accrediting Agency for Clinical Laboratory Sciences (NAACLS) and the American Medical Technologists (AMT).

Useful links:

Clinical laboratory science program, MD Anderson. http://www.mdanderson.org/education-and-research/education-and-training/schools-and-programs/school-of-health-professions/programs-and-courses/clinical-laboratory-science/index.html

American Society for Clinical Laboratory Science: http://www.ascls.org/?page=Career_Toolkit

Clinical laboratory technologists and technicians: http://www.bls.gov/oco/ocos096.htm

Cytogenetics is the study of chromosomal abnormalities underlying human diseases. A cytogeneticist prepares biological specimens such as blood, amniotic fluid, bone marrow, and tumors for chromosome analysis. This involves preparing cell cultures and staining chromosomes using techniques such as fluorescence in situ hybridization (FISH) and knowledge of techniques such as PCR, fluorescence microscopy, nucleic acid purification, agarose gel electrophoresis, and immunofluorescence staining. For a detailed list of skills expected of cytogenetic technologists, refer to the PDF prepared by the Association of Genetic Technologists (AGT). You can find it here: http://www.agt-info.org/Documents/Cyto%20Statements%20of%20Competence%202001.pdf

Education: The minimum educational requirement to be a cytogenetic technologist is an undergraduate in genetics, biochemistry, or biology followed by a cytogenetic technology program and certification (which is required by some laboratories). Choose a cytotechnology program that is accredited by the National Accrediting Agency for Clinical Laboratory Sciences.

An undergraduate degree in cytogenetics may be followed directly by certification. A national certification exam is offered by the Board of Registry of the American Society for Clinical Pathology.

Places of employment: Cytogenetic technologists may find work in research institutions, hospitals, and medical laboratories.

Useful links:

MD Anderson Cancer Center, cytogenetic technology program: http://www.mdanderson.org/education-and-research/education-and-training/schools-and-programs/school-of-health-professions/programs-and-courses/cytogenetic-technology/index.html

Mayo Clinic cytogenetic technology program: http://www.mayo.edu/mshs/cytogen-cytogen.html

Cytogenetic technology program: http://www.uthscsa.edu/shp/cyto/success.asp

Occupational network online, Cytogenetic technologists: http://online.onetcenter.org/link/summary/29-2011.01

Cytogenetic Technologist: http://www.ama-assn.org/ama1/pub/upload/mm/40/ls05-cytogen-tech.pdf

Health Careers Center, Cytogenetic Technologist:

http://www.mshealthcareers.com/careers/cytogenetictechnologist.htm

http://www.wisegeek.com/how-do-i-become-a-cytogenetic-technologist.htm

http://education-portal.com/cytogenetic_technologist.html

Association of genetic technologists: http://www.agt-info.org/

Molecular genetic technologists study DNA for various purposes: to determine familial cancer risk, to diagnose neurological disorders, to identify microbiological agents, to match tissues for organ transplantation, to identify disaster or crime victims, and to determine parentage.

The following are some examples of skills molecular genetic technologists should have, according to the Statements of competence for molecular genetic technologists.

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Syllabus – Genetics

Thursday, August 4th, 2016

Course Description

BIOL 2316 GENETICS (3-3-0) is an introduction to the basic concepts of human heredity and cytogenetics including Mendelian, molecular, and population genetics. Prerequisite is BIOL 1406 Cell and Molecular Biology or BIOL 2304 Human Anatomy with minimum grade of C.

Instructional Methodology

This is a three-credit lecture course.

Course Rationale

BIOL 2316 Genetics is an intensive sophomore-level course that explores modern genetics. The course is divided into three parts.

Common Course Objectives

The common course objectives are available at http://www2.austincc.edu/biology/ccobjectives.

Grading Rubric

TESTS: There will befour unit tests whose dates are listed on the attached schedule. Each of these tests is worth 100 points. Each test will have 10 questions and will be designed to be completed in one hour in class. There is no curve. Students who receive below 70 on a test may hand in test corrections within 1 week to receive up to 6 additional points. One make-up test is allowed with prior permission of the instructor. Contact me in advance to arrange for a make-up test. Tests are given on material discussed in class, so regular attendance is strongly encouraged.

CLASS ACTIVITIES: Activities are given out throughout the semester to reinforce ideas discussed in lecture. These are usually small group activities and are graded at 5-10 points each. One make-up is allowed if a student is absent. It is the students responsibility to complete these class activity sheets and hand them in for grading. The grading rubric will be adjusted at the end of the semester to reflect the exact number of class activity points that may be obtained this semester.

HOMEWORK PROBLEMS: The study of genetics involves considerable problem-solving. Therefore, homework problems are provided for each chapter. There will be a total of 100 questions assigned, each one worth 1 point. These problems are similar to questions on the test, so successful completion usually improves test grades. Each problem set is due the week following the day the relevant chapter was discussed in class. Late homeworks will be accepted, but will be discounted 5% for each class they are late. Late homework handed in after the test date will not be accepted.

POWERPOINT PRESENTATION: Each student will develop a PowerPoint presentation on a genetic disease or syndrome to be handed in on April 19 as indicated on the syllabus. Details will be provided later in the semester.

Grade Component

Points

4 tests @ 100 pts each

400

Class activities

~50

HW problems

100

PowerPoint disease project

50

Total points

600

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Syllabus - Genetics

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University of Wisconsin Laboratory of Genetics

Thursday, August 4th, 2016

Honor the Life and Accomplishments of Professor Jim Crow with a Donation to The Crow Professorship

Over the next year, The Laboratory of Genetics will honor Professor Jim Crow in anticipation of what would have been his 100th birthday. A birthday celebration will take place in Fall 2016 in the form of a symposium and dinner. In preparation for the fall celebration, the department is focused on reaching a $1 million goal to have a professorship in Prof. Crows honor. If the Crow Professorship fund reaches $50,000 in gifts and pledges by June 8, the new gifts and pledges will be matched dollar for dollar.

Click here to read the full article and make a donation to The Crow Professorship.

Welcome to the University of Wisconsin-Madison Laboratory of Genetics. The Laboratory of Genetics is comprised of two sister departments that function as one. The Department of Genetics in the College of Agricultural and Life Sciences was founded in 1910 and is the oldest genetics department in the country. The Department of Medical Genetics, which recently celebrated its fiftieth anniversary, is housed within the School of Medicine and Public Health. Our mission is to address fundamental problems in genetics as they relate to medicine, agriculture, and basic knowledge of biology.

The Laboratory of Genetics is also home to the Genetics Training Program, with over 80 faculty trainers from diverse departments on campus that together provide graduate students diverse opportunities in modern genetics research. Please visit our pages to find out more about us.

John Doebley Chair, Laboratory of Genetics

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University of Wisconsin Laboratory of Genetics

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Genetics (B.S.) | Degree Programs | Clemson University, South …

Thursday, August 4th, 2016

The first major-specific course required of freshman genetics majors is Careers in Genetics and Biochemistry. This introductory course brings in professionals to aid students in discovering the diversity of career opportunities available from this degree. This course also helps you become aware of professional organizations, ethical issues and the requirements for advanced studies.

In the first two years at Clemson, youll take various science courses such as general and organic chemistry, biology, physics and mathematics.These will prepare you for upper-level course work that includes molecular biochemistry, molecular and general genetics, comparative genetics and population genetics. Additionally, youll be able to tailor your degree to your specific interests by selecting from approved scientific courses such as microbiology, immunology, and human anatomy and physiology.

Genetics students spend quite a bit of time in Clemsons laboratories with our nationally recognized faculty. Our faculty have diverse research interests from alternative fuel to molecular parasitology. You also have a chance to participate in internships and study abroad, as well as join any of Clemsons hundreds of student organizations.

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Genetics Clinic – University of Iowa Children’s Hospital

Thursday, August 4th, 2016

About Inherited Conditions

Many diseases and disorders are caused by a persons genetic makeup. These include abnormalities in genes that occur randomly or because of environmental exposures. Other genetic factors run in the family and are inherited at birth from one or both parents.

The Division of Medical Genetics, based in the University of Iowa Department of Pediatrics and UI Childrens Hospital, is a comprehensive statewide resource for families and health care professionals.

Our multidisciplinary team provides hospital- and clinic-based medical care for children and adults with genetic conditions. Testing, diagnosis, counseling, and treatment services include:

We understand that genetic diseases and disorders affect families as well as individuals. Our medical team provides the information, support, and follow-up you need to make informed decisions. We will work with your family physician so you will continue to receive the best all-around care as you move forward. We also collaborate with state and federal agencies, educators, researchers, support groups, and others to provide the latest information and treatment options for Iowans and their families.

From Our UI Children's Hospital Specialists

Read more health library articles on pediatric genetics

A new standardized test for infants alerted doctors to Zachs MCAD deficiency, possibly saving his young life.Read more about Zachs story.

Zephan was born with Alagille syndrome and has had many surgeries because of it, but has made giant strides.Read more about Zephans story.

Andrew was growing up a little bit smaller than the rest of his classmates and new tests revealed why.Read more about Andrews story.

Parking: Parking and Wayfinding. Valet Services Available In House Directions: Elevator F, Level 2.

Monday through Friday 8 am-5 pm

Physician, Pediatrics

Nurse Practitioner

Physician, Pediatrics

Physician Assistant

Nurse Practitioner

Nurse Practitioner

Physician, Pediatrics

Physician, Pediatrics

Physician, Pediatrics

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Genetics Clinic - University of Iowa Children's Hospital

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