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Archive for the ‘Diabetes’ Category

Smartphone ‘orders’ body to treat diabetes – BBC News

Saturday, April 29th, 2017

BBC News
Smartphone 'orders' body to treat diabetes
BBC News
Scientists have used a smartphone to control the activity of the living cells inside an animal. The fusion of biology and technology was used to control blood sugar levels in mice with diabetes. The idea, described in Science Translational Medicine ...
DailyTech - Smartphone 'Orders' body to treat diabetesDailyTech
We Now Have an App That Can Activate Cells That Manage DiabetesFuturism
Smartphone-controlled cells help keep diabetes in checkScience Daily
Genetic Engineering & Biotechnology News -New Atlas -IEEE Spectrum
all 21 news articles »

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Messy litter box could mean diabetes for indoor cats – Palm Beach Post

Saturday, April 29th, 2017

Question: My cat is suddenly making a mess in his litter box. It is full of pee spots and really large-sized ones. He used to only pee in one small spot a day; now it is several large spots.

He acts fine and is eating good. He has always been a chunky cat, but I think he has lost a little weight recently.

Answer: I am glad that you are monitoring your kittys litter box so well. It is important to know what is normal for your cat. Most cats only urinate once or twice a day. When the amount in the litter box suddenly increases, it is a good indication that there is a problem. Please monitor his water and food intake as well. He is probably drinking a good bit more water.

Your kitty will need a trip to his veterinarian to check a urine sample and do a thorough physical examination. Many times, blood testing will be necessary to fully diagnose the problem. Things that can cause increased urination are: diabetes, kidney disease, infection, tumor, crystals or stones in the bladder, and thyroid disease. All of these can be serious, if left untreated.

Diabetes is most often seen in indoor cats that are overweight. The sooner they are diagnosed and treated, the better they tend to do. Diabetes occurs when blood sugar levels get too high and the body cannot utilize it. Insulin is needed to help absorb blood sugar and get nutrition to the cells that need it. When too much glucose (sugar) is in the bloodstream, it is flushed out in the urine and takes excess water with it this causes your cat to drink larger amounts of water and urinate at larger volumes. Diabetes in cats can be treated with insulin injections and a special diet high in protein, with little or no carbohydrates.

Cats are true carnivores, so too much carbohydrates in the diet are not tolerated well. Diabetes in cats can be reversed if caught quickly, however, changes must be made to control blood sugar, weight and diet.

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Diabetes, weight gain can alter your brain, says study – WTAE Pittsburgh

Saturday, April 29th, 2017

(CNN)

It's well-known that type 2 diabetes can cause medical complications in certain organs, including the brain. But overweight and obese people with early-stage type 2 diabetes have more severe abnormalities in brain structure and cognition than normal-weight people with type 2 diabetes, according to a new study in Diabetologia, the journal of the European Association for the Study of Diabetes.

Having type 2 diabetes and being overweight, then, can combine to have a greater effect on brain structures.

"There's a general agreement that type 2 diabetes is a risk factor for various types of both structural and functional abnormalities in the brain," said Dr. Donald C. Simonson, a co-author of the study and an endocrinologist specializing in diabetes. "Simple obesity also shows the same type of abnormalities ... in a milder stage. You can see where it's not quite exactly normal but not quite as bad as someone with diabetes.

"So, if you have both, will it be worse than if you have them alone? That's what we looked at in this particular study," said Simonson, who teaches at Harvard's T.H. Chan School of Public Health.

Dr. In Kyoon Lyoo, lead author and a professor at the Ewha Brain Institute at Ewha Womens University in Seoul, South Korea, wrote in an email, "As obesity has been known to be associated with metabolic dysfunction, inflammation, and brain changes independently of diabetes, we expected that brain alterations might be more pronounced in overweight/obese participants with type 2 diabetes."

Effects on the brain

Lyoo, Simonson and their colleagues designed a study around 50 overweight or obese people age 30 to 60 who had been diagnosed with type 2 diabetes.

Fifty normal-weight people diagnosed with type 2 diabetes and 50 normal-weight people without diabetes also participated. These additional participants were age and sex matched to the original group. Those diagnosed with diabetes were also matched for disease duration. Standard body mass index ranges defined "overweight" (having a BMI of 25 to 29.9), "obese" (greater than 30) and "normal weight" (18.5 to 25).

The researchers used magnetic resonance imaging to examine each participant's brain structure, including the thickness of the cerebral cortex and white matter connectivity. Gray matter in the brain contains the neuron cell bodies, whereas white matter contains bundles of nerve fibers and its job is to process and send signals along the spinal cord.

The researchers chose to study thickness and connectivity "because these could be sensitive markers of diabetes-related brain changes, and could be reliably quantified by using magnetic resonance imaging," Lyoo explained.

Participants also were tested for memory, psychomotor speed and executive function, since these are known to be affected in people with type 2 diabetes.

The results aligned with the researchers' initial assumptions, Lyoo said.

Clusters of gray matter were significantly thinner in the temporal, prefrontoparietal, motor and occipital cortices in the brains of diabetic participants than in the non-diabetic group, the study found. More thinning of the temporal and motor cortices could be seen in the overweight/obese diabetic group compared with normal-weight diabetics. Separately and collectively, these areas of the brain impact motor control, executive function, body awareness, concentration and other cognitive functions.

"Most of the things we looked at, you could see that there was a progression, and the obese patients with diabetes were worse than the lean patients with diabetes, and they were both worse than the age-matched controls," Simonson said.

In particular, the temporal lobe appears vulnerable to the combined effects of type 2 diabetes and being overweight or obese, the researchers say. The temporal lobe is implicated in language comprehension and long-term memory.

The brain has been the last frontier in the study of complications of diabetes, Simonson said.

Similarities to Alzheimer's disease

"Diabetic retinopathy, eye disease, is reasonably well-understood," he said. "The same is true of kidney disease, amputations -- we understand much better what causes them and how to prevent them.

"But the brain has been the proverbial black box. It's incredibly complicated, and you can't directly study it. You can't go in and take samples," he said. "The last several years, the techniques of MRI got good enough that we could really look carefully at the brain."

Most of the initial work in the very late 1990s was done in Alzheimer's, schizophrenia, depression and other classic psychiatric diseases, but then scientists began to look at other diseases including diabetes, explained Simonson. At this point, researchers around the world began to see connections.

"You can see a person with depression has thinning of the surface of the brain in certain areas, and you go in and do the same study with somebody with diabetes, and they have thinning in the exact same areas," Simonson said. And diabetes may be a predisposing or risk factor for developing Alzheimer's, he said.

"You see the same types of abnormalities in a milder form in the brain in people with diabetes that you see in people with Alzheimer's disease," Simonson said.

According to Dr. William T. Cefalu, chief scientific, medical and mission officer of the American Diabetes Association, the study is consistent with previous research.

"The presence of overweight and obesity have been shown in other studies to be associated with early structural changes in the brain, and may contribute to cognitive issues," said Cefalu, who was not involved in the new study. "The current study implies that obesity/overweight status in individuals with diabetes may also contribute."

That said, longer-term and more definitive studies are needed to evaluate that aspect.

In the end, Simonson said, another question is more important: "What can you do to prevent it? That's the big question."

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Diabetes, weight gain can alter your brain, says study - WTAE Pittsburgh

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Extension offering free diabetes education – WJBC News

Saturday, April 29th, 2017

The local University of Illinois Extension is giving people a chance to become more educated about diabetes. (WJBC File Photo)

By Cynthia Grau/WJEZ News

EUREKA The local University of Illinois Extension is providing information to get a handle on diabetes.

The Extension is offering I on Diabetes, a four-part series beginning May 1 in Eureka.

Jenna Smith, nutrition and wellness educator and registered dietician for the Extension, explained how the class works.

It is really designed to help you manage diabetes, and if you dont have diabetes, its really a good program to help you think about ways to prevent diabetes, because no one wants that. Its a great program that usually costs money, and this year, it is absolutely free, because we got a grant. So Im super excited about that, Smith said.

To register, call 309-467-3789 or visit go.illinois.edu/lmw.

Cynthia Grau can be reached at cynthia.grau@cumulus.com

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Cyclist turns a death sentence into a race against diabetes – CNN

Friday, April 28th, 2017

"My mom took me to one doctor who said, 'Your kid has got the flu. Come back in one week,'" he said.

"They said, 'Ma'am, we've got good news, and we've got bad news. The good news is your son's gonna live for now. The bad news is, he's got diabetes. He's got to take shots of insulin, and most likely he'll be dead by 25. If not, he'll either be blind or have renal failure,'" he said.

As he grew up in Tallahassee, Florida, Southerland was determined not to let this death sentence stop him. At 6, he was already managing his Type 1 diabetes on his own.

"For me, it was all I ever knew. I knew I had to breathe, I knew I had to eat and I knew I had to check my blood sugar and give myself insulin shots."

His parents stored only healthy food in the house to keep him from making bad choices. But at 12, Southerland disobeyed the rules and ate a candy bar. That decision would change his life.

"I figured OK, I don't want to wait two hours for my insulin to kick in. I do want to eat these candy bars. How can I do it?" he recalled.

So he hopped on his bike and rode through the neighborhood until his legs got tired.

"That was my journey to start riding," he said. "The bike for me was freedom."

The more he exercised, the less insulin he needed, and the easier it was to manage the disease.

"The bike gave me the discipline and motivation I needed to control my diabetes," he added.

The first sporting goal of the organization was to have a team of athletes compete in the Race Across America, a 3,000-mile bike trek through 12 states.

"We lost the race by three minutes," Southerland said. "So we came back the next year a little smarter in how we manage diabetes, a little more experienced in the race, and we set a world record of 5 days, 15 hours and 43 minutes."

To ensure safety, the organization provides a medical team to support riders during a race. Cyclists undergo a stringent testing regime in the three hours leading up to a race. They also use continuous glucose monitoring, which will sound an alarm if their levels get too high or too low.

In 2008, Southerland created a professional team of diabetic cyclists.

"I was supposed to be dead when we started Team Type 1 as a professional cycling team," he said.

But he was far from it. Southerland competed as a professional cyclist for two years until some injuries took him out of the sport.

Now 35, Southerland's goal is to field the first all-diabetic team in the Tour de France by 2021.

"I believe sport can be the unifying point for people with diabetes," he said.

Southerland's other passion is helping diabetic kids in Rwanda get much-needed medical supplies.

"I nearly put our company out of business in 2010 ... because I bought 400 blood glucose monitors, and I took about 40,000 test strips in bike boxes to the Tour of Rwanda," he said.

"We gave them out to the kids there. Their parents were all in tears because their kids have this tool, which is gonna help them live," he added. "It ripped my heart out."

Every year since then, the organization has continued to send supplies to Rwanda.

"I want every kid with diabetes to know that they are the hero. Every person with diabetes to know that their dreams can come true."

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Type 2 Diabetes May Be Bad for Brain Health – WebMD

Friday, April 28th, 2017

By Serena Gordon

HealthDay Reporter

THURSDAY, April 27, 2017 (HealthDay News) -- Previous research has linked type 2 diabetes and memory loss. Now, new research may be closing in on some of the reasons why.

The study found that people with type 2 diabetes -- particularly those who are overweight or obese -- have thinner gray matter in several areas of the brain.

These brain regions are related to memory, executive function, movement generation and visual information processing, said the study's senior author, Dr. In Kyoon Lyoo. He's director of the Ewha University Brain Institute in Seoul, South Korea.

"Obesity leads to increased risk of type 2 diabetes, metabolic dysfunction and is also associated with brain alterations independently," Lyoo said. "We aimed to investigate whether overweight/obesity influenced brain structure and cognitive function in individuals with early stage of type 2 diabetes."

The study included: 50 overweight or obese people with type 2 diabetes; 50 normal-weight people with type 2 diabetes, and 50 normal-weight people without diabetes.

The Korean study volunteers were between 30 and 60 years old. Those with diabetes had it for five years or less, and they were attempting lifestyle modifications and/or taking oral medication to lower blood sugar levels. No one was taking insulin.

The normal-weight group with type 2 diabetes had slightly better blood sugar control -- a hemoglobin A1C level of 7 percent. The overweight folks with type 2 diabetes had hemoglobin A1C levels of 7.3 percent.

Hemoglobin A1C is a two- to three- month estimate of average blood sugar levels. The American Diabetes Association generally recommends an A1C of 7 percent or less.

All study participants underwent MRI brain scans and tests to measure memory and thinking skills.

"Cortical thickness was decreased in several regions of the diabetic brains. Further thinning of the temporal lobes found in overweight/obese individuals with type 2 diabetes suggests that these regions are specifically vulnerable to combined effects of obesity and type 2 diabetes," Lyoo said.

He said this study alone cannot tease out whether the effect is from excess weight or diabetes or both. But the study did find that the longer someone had diabetes, the more likely they were to have brain changes.

Lyoo said factors such as insulin resistance, inflammation and poor blood sugar management might bring about the changes.

Memory and thinking skills were decreased in people with diabetes -- regardless of weight -- compared to the normal-weight people without type 2 diabetes, the study found.

Because the study only included an Asian population, Lyoo said it isn't clear if these effects would apply to other populations, such as Americans. He also said it isn't known if these effects occur in people with type 1 diabetes, the less common form of diabetes.

Dr. Sami Saba is an attending physician in neuromuscular medicine and electromyography at Lenox Hill Hospital in New York City.

"The regions most affected were the temporal lobes, which are also most prominently affected in people with Alzheimer's," he said of the research.

"While this was not proven on this study, it does suggest that those with diabetes who are also overweight are at higher risk for developing Alzheimer's-type cognitive impairment than those with diabetes who are not overweight," Saba said.

But, he also noted that a major limitation of this study was the lack of overweight/obese people without diabetes to serve as a comparison group.

The take-home message, said Saba, is that weight control is an "important factor in preserving brain health in these patients." He said it's one more reason to work to prevent weight gain.

Lyoo said good blood-sugar management would probably help slow down or prevent these diabetes- or obesity-related brain changes.

Dr. William Cefalu is the chief scientific, medical and mission officer for the American Diabetes Association.

"The presence of overweight and obesity has been shown in other studies to be associated with early structural changes in the brain, and may contribute to cognitive issues," he said.

But, he said that diabetes may also play a role. Both Lyoo and Cefalu said that more research is needed to figure out which factor is at the root of these changes.

The study was released April 27 in the journal Diabetologia.

WebMD News from HealthDay

SOURCES: In Kyoon Lyoo, M.D., Ph.D., director, Ewha University Brain Institute, Seoul, South Korea; Sami Saba, M.D., attending physician in neuromuscular medicine and electromyography, department of neurology, Lenox Hill Hospital, New York City; William Cefalu, M.D., chief scientific, medical and mission officer, American Diabetes Association; April 27, 2017, Diabetologia

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With a motor and a mentor, elite basketball recruit Cate Reese moves forward with diabetes – ESPN

Friday, April 28th, 2017

By Walter Villa | Apr 27, 2017 Sepcial to espnW

Courtesy the Reese family

Senior night was emotional for Cate, left, and Ali Reese, not to mention all the friends and family in the stands.

When Cate Reese was 2 years old, she scampered on tiny legs from the front door of the family townhouse to the back. Then she did it again. And again. And again.

Fifteen years later, the 6-foot-3 junior forward for Cypress Woods (Cypress, Texas) and the No. 14 prospect in the espnW HoopGurlz Super 60 for 2018 class is still in constant motion. Reese beats opponents from rim to rim. She fidgets in the huddle. She chews gum incessantly. Movement every second.

"It's crazy how much gum I buy," said her mom, Cheryl. "I buy 10 packs at a time, and she blows through it."

Reese has been a starter since her freshman year, when she helped lead Cypress Woods to its only state title. She averaged 22.3 points and 13.2 rebounds this past season, making first-team all-state.

Not even the life-altering news she got a year ago has been able to stop her.

On April 4, 2016, Reese was told she had Type 1 diabetes, a diagnosis that stunned her even though her older sister, Ali, has dealt with the same disease for the past eight years. Cate had hoped to avoid that fate.

"Initially, it was devastating for Cate," Cypress Woods coach Virginia Flores said. "I pulled her into my office and asked her what was getting to her the most about her situation. ... To her, everything and everyone is beatable. But diabetes is not something you defeat. It's something you manage. So when she said, 'This is forever,' my heart just broke for her in that moment."

She's learned a lot about her disease and herself since that day.

"It's made me see life through a different perspective," she said. "You only get one life to live. I'm grateful I can still play. I'm still here."

Courtesy the Reese family

Basketball programs across the country are trying to land Cate Reese, right, for college. It could be that she'll stick by her sister's side.

Reese was a premature baby, and she was kept in the hospital's neonatal intensive care unit for three weeks because her lungs were not developed enough at birth.

Cheryl said she never saw her daughter cry or even move.

She was brought home on a memorable Thanksgiving eve. Soon after, came the pulling, pushing, crying. And crawling. Before long, her favorite saying: "Are you going to eat that?"

She was precocious, too. At age 4, she told her parents she was no longer Catherine or Catie. She was Cate. "I guess I was pretty sassy," Reese said.

She started playing basketball at age 7, and she has grown in her game and in her stature. She is six inches taller than her sister and mother and maybe just a hair taller than Bill, her father.

Bill, by the way, wasn't much of an athlete and didn't expect Cate to be nearly this good.

"She was always tall, but she was gawky," he said. "I always used to tell her, 'You are going to be this tall [player] at the end of the bench.'"

Courtesy the Reese family

Ali Reese, left, recognized the danger signs in Cate and has helped guide her through the uncertain times caused by diabetes.

Bill Reese was spectacularly wrong.

By Cate's freshman year, she averaged 12.2 points and 8.3 rebounds on that championship team that featured five other Division I recruits. She averaged 20.8 points and 12.8 rebounds as a sophomore, the same year she joined the Texas Elite AAU team.

It was there that she impressed coach Joey Simmons.

"She's a bulldog," Simmons said. "She plays as hard as anybody I've coached. If the ball is loose, she is diving at it, jumping for it, pushing, shoving -- anything it takes. She never stops the whole game. She's a special player when it comes to being relentless."

You only get one life to live. I'm grateful I can still play. I'm still here.

Cate Reese

Simmons said Arizona, South Carolina and Texas A&M have been pushing hard to sign Reese. But Reese said she has yet to decide on favorites.

She is grateful, however, that her parents have been involved, accompanying her on unofficial visits to numerous colleges. Reese said she prefers a warm-weather school but is open to all possibilities. So far, she has visited Colorado, Washington, SMU, Texas Tech, Baylor, Texas Christian, Oklahoma State, Rice, Arizona, South Carolina, Texas A&M and George Washington, and she has scholarship offers from all those schools.

"She's a phenomenal athlete," Ali said of her sister, who is a senior on the Cypress Woods team. "She has a huge passion for the game that I don't see in other people."

Indeed, Cate's competitiveness is legendary among those who know her well.

"When I lose," Cate said, "it's not a fun car ride home."

Ali wants to study nursing but will not continue with basketball in college. Cate, who has more than 1,000 career rebounds and is less than 200 away from 2,000 points, wants to pick a school by September.

Both girls want to attend the same college, if possible. So wherever Ali goes ... Cate may follow.

Courtesy the Reese family

The one thing Cate Reese didn't want to share with her sister was diabetes.

The sisters have always been close, but the events of the last year have brought them even closer.

It was Ali who saw her sister overly thirsty last year and immediately tested Cate's blood sugar, forcing an urgent trip to the hospital and avoiding a situation that could have become dire if left unattended.

And it's Ali who has been there to answer Cate's questions, let her know what to expect and guide her in her new reality.

On the court, though, the sisters yelled at each other so much that Flores told them they would not play together if they couldn't find a way to get along.

"I get very passionate, and I yell at people," Cate said. "But I don't mean it like that -- I just get excited."

Cate is disappointed that Ali has chosen not to pursue college basketball.

"She has the skills to play at the next level," Cate said. "I love basketball so much that it's hard to believe when others don't love it as much as I do."

A couple of months ago, on senior night, tears flowed on the court as fans, friends and family watched the ceremony. And the sisters.

"Along the way," Cate said, "I've met a lot of teammates who have become like my sisters. But it's been great the past two years of high school and the past four years in AAU to play with my actual sister. It's hard to put into words how much she means to me. She's my biggest supporter and my best friend. I don't know what I would do without her."

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Diabetes Fundraiser Adds Extreme Ninja Course – CBS Local

Friday, April 28th, 2017

By Libby Smith

DENVER (CBS4) The American Diabetes Association kicked off fundraising for its Tour de Cure event this week.

Tour de Cure features a family-friendly walk, a 5-K run, four bike tour routes, and, new this year, an obstacle course. The Extreme Ninja Course will have up to nine obstacles that participants will need to get through.

LINK: Tour de Cure 2017

We want to be dynamic in the field of events, said Brandi Miller, the coordinator for Tour de Cure.

CBS4s Ashton Altieri tries out the Xtreme Obstacle Course. (credit CBS)

Xtreme Obstacle Course is the company that will be providing the course for Tour de Cure, and they had a smaller version set up at Blue Moon RiNo Brewery for the kickoff event Thursday. CBS4s Ashton Altieri tried out the course. At Tour de Cure, contestants can compete individually or in teams.

LINK: Xtreme Obstacle Course

Between the new ninja-style course, the walk, the run and the bike tours, the ADA hopes to raise $1,400,000.

(credit CBS)

The money thats raised at Tour goes to our advocacy. It goes toward research. It goes towards our programs that we have here in Colorado. We have camps for kids living with diabetes, Miller explained.

(credit CBS)

Lockheed Martin has been a part of Tour de Cure for at least the 10 years Ive been doing it, said John Donovan, leader for the local Lockheed Martin team.

So John, your team was the top fundraising team nationally, tell me about your fundraising strategy? Altieri asked Donovan.

The strategy is getting a large membership and encouraging those people to go out and just get $5 or $10 from somebody. It can be coworkers, it could be family, it could be neighbors, Donovan replied.

Tour de Cure is Saturday, Sept. 92017. Now is the time to sign-up for an event, form a team, begin your training, and start fundraising.

Libby Smith is a Special Projects Producer at CBS4. If you have a story youd like to tell CBS4 about, call 303-863-TIPS (8477) or visit the News Tips section.

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Calling All Heart Docs – Your Diabetes Drugs Need You – Seeking Alpha

Friday, April 28th, 2017

Astrazeneca (NYSE:AZN) followed Johnson & Johnson (NYSE:JNJ) and Eli Lilly (NYSE:LLY) this morning by delivering a disappointing performance from its SGLT-2 inhibitor Farxiga. The drug belongs to a class that is widely projected to become the fastest growing among diabetes medicines (see tables below).

As such, weak first-quarter sales from the main players is worrying, and the blame is being laid at the feet of US pricing pressures. Diabetes is an area where payers have successfully flexed their muscles. However, it seems that another factor is playing a role: the message that this class can reduce a patient's risks from heart disease is taking time to have an impact.

Astrazeneca said growing intra-class competition and the impact of affordability programmes and managed-care access subdued Farxiga growth in the US, where sales inched only 2% higher, to $96m, in the first quarter.

J&J painted an even worse picture with Invokana - lower prices caused US sales of the medicine to fall 13% on the same quarter of last year. The company also blamed increasing discounts for managed care and a higher composition of Medicaid sales, where prices are typically lower.

The Lilly result was probably the most surprising given that the company has been heavily marketing Jardiance's success in its cardiovascular outcome study since January. New patient starts have surged 75% since the company was allowed to begin marketing on evidence that the drug can reduce the risks of death and complications from heart disease, the company said this week. However revenues still came in lower than the sell-side was expecting.

Lilly and partner Boehringer Ingelheim are the only companies allowed to actively market a cardiac benefit for their SGLT2, although big studies are due to report on Invokana and Farxiga in the next couple of years. These are widely expected to confirm a class effect, helping to drive use of all of these medicines (ACC - Jardiance heart benefit looks like a class effect, March 20, 2017).

However, the finding represents a big philosophical shift for this area of medicine, which is more used to dealing with the discovery of safety signals.

"We have to remember we are talking about changing very well entrenched treatment practises and physicians do take some time to get comfortable with new drugs and new classes," said Mark Mallon, head of Astrazeneca's global product strategy and medical affairs, in a media call this morning. "They need to see the data and the data is absolutely coming. But it's going to take time to build that up."

Assuming the class effect is confirmed, having three companies actively promoting a cardiac benefit will surely help drive uptake. However another issue is bringing cardiologists on board - endocrinologists and primary care doctors are currently the main prescribers of these drugs - an issue that Lilly executives have said they are closely monitoring.

"Cardiologists, in the case of Jardiance, are a significant source of authority. And while we have seen an increase, the base of prescribing is extremely, extremely small," Enrique Conterno, head of Lilly's diabetes business, told analysts on a call last week.

Merging therapy areas

The discovery of cardioprotective benefits for the SGLT2s and to a lesser extent the GLP-1 agonists points to a merging of therapy areas that looks set to become only more apparent in the coming years.

Novo Nordisk (NYSE:NVO) has already won approval for Victoza as an obesity therapy. Astrazeneca this year started two outcome trials with Farxiga in heart failure and chronic kidney disease, which will recruit both diabetic and non-diabetic patients. And its blood thinner Brilinta is being trialed in diabetic patients in the huge Themis study, to see if it can reduce the risk of heart attack and stroke.

The UK pharma giant has even merged its cardiovascular and diabetes drugs into a single reporting unit, which chief executive Pascal Soriot put down to more and more overlap.

"We believe there are substantial synergies across those therapy areas - operationally in the field but also from a medical view point," he told journalists earlier today.

A cynic might also see the move as a convenient way to de-emphasise Brilinta, sales of which have long disappointed.

However it is readily apparent that the SGLT2s have the potential to steer the treatment of diabetics closer to the cardiovascular world than ever before. The extent to which these drugs will be embraced by cardiologists is hard to foresee until more trials report, but could have a huge impact on the commercial potential of the class.

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Calling All Heart Docs - Your Diabetes Drugs Need You - Seeking Alpha

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Diabetes app forecasts blood sugar levels: First-of-its-kind … – Science Daily

Friday, April 28th, 2017

Healthline
Diabetes app forecasts blood sugar levels: First-of-its-kind ...
Science Daily
Glucoracle is a new app for people with type 2 diabetes that uses a personalized algorithm to predict the impact of particular foods on blood sugar levels.
Diabetes App Designed to Predict Blood Sugar Levels After Each MealHealthline

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Overcoming diabetes through churches in Columbia’s African-American community – Columbia Missourian

Thursday, April 27th, 2017

COLUMBIA Verna Laboy's paternal grandmother lost both legs to diabetes complications. Very recently, one of her cousins lost a leg also to diabetes. Yet another cousin is on dialysis, a complication of the same disease.

"This is personal for me," she says.

She doesn't pretend to be an expert that's not where the passion comes from. She, herself, was "on the fast track" to diabetes and has found it hard to stick with an exercise or diet.

All of that has made Laboy a passionate force behind Live Well By Faith, a wellness program launched one year ago through the Columbia/Boone County Health and Human Services Department for black churches in Boone County.

Data from a county-wide survey in 2013 showed that of the 9,300 people living with diabetes in Boone County, black people were four times more likely to die from complications related to the disease than their white counterparts. Nationally, black women are just under two times more likely than white women to die from diabetes complications, while black men are about one and a half times more likely than white men to die from diabetes complications, according to the Centers for Disease Control and Prevention.

Type 2 diabetes the more common form of the chronic disease occurs when the level of blood glucose (sugar) in a person's body is higher than normal because insulin ceases to be produced properly, according to theAmerican Diabetes Association. As a result, the body's cells are starved for energy and the eyes, kidneys, nerves and heart can be effected. Factors associated with diabetes include obesity, a family history of the disease and race and ethnicity.

Verna Laboy saves leftover food April 2 after the Live Well By Faith cooking class. Laboy runs the Live Well By Faith wellness program through St. Luke United Methodist Church in Columbia, which aims to address health disparities in minority communities through church programs.

Laboy, a self-proclaimed "health evangelist" and community activist, has been working with black churchgoers since April 2016 to educate people about the consequences of unhealthy lifestyles, to encourage healthy eating and to provide programsfor long-term success in health management.

"Food is important to this culture, and it's cooked the wrong way. It's a lethal digestion," Laboy said. "It's an addiction that needs to be addressed, a very unhealthy addiction. We need to increase our health literacy."

Laboy uses the word "bulldozer" to describe how she's paving the way towards bringing down the rates of diabetes and heart disease among blacks in Boone County.

"I don't have a health background. I'm not a personal trainer. I'm not a nutritionist," she said.

Her own struggle to change her lifestyle has been a source of insight.

"But I've been on this journey for years, unable to stay consistent," she said.

She and other "health ministers" at the Live Well By Faith-accredited churches are "looking for people that are dealing with the challenges themselves to adopt (healthy) behaviors and see the changes and take people on the journey with them," she said.

Laboy enthusiastically and passionately evangelizes on a healthy lifestyle.

"Verna's not doing the work," she said, slipping into third person, as she often does. "You have to do the work. This is your church. This is your congregation. This is your family. This is your life."

Diabetes can lead to high blood pressure, heart disease, amputations and death if not managed well, according to the American Diabetes Association.

Lifestyle factors and genetics are the primary influences of type 2 diabetes, according to a study published in 2012. Type 2 diabetes involves insulin resistance and declining insulin production and components of the disease include physical inactivity, sedentary lifestyle, cigarette smoking and a generous consumption of alcohol.

Maintaining a healthy diet for the prevention or treatment of diabetes combined with physical activity is associated with lowered risks of diabetes, according toa study published by the Journal of Education and Health Promotion. Eating smaller serving sizes and cutting calories improves insulin sensitivity, and regular physical activity helps with weight loss and may also decrease blood pressure.

Increasinghealth literacy entails learning about what types of foods are recommended for healthful living, what types of food to avoid and fitness.Focusing meal planning around nutrient dense foods such as vegetables, beans, whole grains, fruit, non-fat dairy, fish and lean meats is one way to decrease the risk of diabetes, according to theAmerican Diabetes Association.

But the church is an especially important institution for many black Americans.

From left, Frances Logan, Shae Brown and Mary B. Warren wash their hands during the Live Well By Faith cooking class April 2 in Columbia. Each attendee washed their hands for 20 seconds, which was a technique they reviewed at the start of the workshop.

Annabelle Simmons, a health minister at St. Luke United Methodist Church, joined the Live Well By Faith team . After she took a healthy lifestyle class through the program, she said her eyes were opened about health.

But she wasn't sure exactly which of the possible Life Well by Faith courses she would teach.

There it was: "Cooking Matters." She thought to herself, "I know how to cook," but had to become certified to teach it. That entailed learning about how to hold a knife properly, how to slice correctly, among other kitchen skills.

The healthy cooking and eating topics changed her habits: learning how to read food labels, how much food is in a serving, the calorie count, the protein count, etc. "And now, every time I go shopping, I'm looking at the labels, so I know it works," she said.

The class also teaches people how to cook healthy food on a budget, Laboy said: "They can see how cheap they can cook good food, healthy food."

In addition to what she learned in "Cooking Matters," Simmons also learned how to take a blood pressure reading, which she does on Sundays free if church members ask her to do so. The health ministers at St. Luke also signed off on a water policy, requiring that water be offered with every meal offered at a church event.

"People were going, 'But I want punch, I want coffee,'" Simmons said.

A "no fried foods" policy is also in place.

And yet, people still gather around the table.

"We get to fellowship with one another around food, preparing the food together," Simmons said.

Dee Campbell-Carter, a lifestyle coach for the health ministry at Friendship Missionary Baptist Church, said the church will start a "Cooking Matters" class later this year. The health ministry at Friendship Baptist offers blood pressure checks every second and fourth Sunday before and after service lets out as well as "SweatSuit Sundays," when the congregation stops in the middle of service to do high- and low-impact exercises to gospel music.

"The thing we're doing is building a faith community that's cross-pollinating," Laboy said. This means that if a class is offered at one church, all the other churches are invited to send participants.

Dee Campbell-Carter, left, and Dorothy Slaughter tend to a garden plot April 17 at Friendship Baptist's community garden. Campbell-Carter is in charge of the garden, which came to fruition in January.

As the sun set last week, Campell-Carter strolled between garden plots behind Friendship Missionary Baptist filled with budding greens, tomatoes and peppers while bees hovered over dandelion-covered grass. Campbell-Carter and community member Dorothy Slaughter tilled the soil, pulling weeds and watering mustard and collard greens and kale.

The garden is called "Friendship Gardens," and the food harvested in the plots will be used in the "Cooking Matters" class when it begins.

Half-built garden beds lay ready for the next stage: being raised on stilts for planting. They will be waist high to accommodate children or those who are wheelchair bound, Cambell-Carter said.

The garden is a placewhere church memberscan grow healthy produce to take home and cook.

Cambell-Carter described Slaughter as the go-to gardener. She taught the community how to dig weeds out from their root with a simple tools like a plastic knife, and that coffee grounds are a good fertilizer and deterrent for some pests.

Calvin Miles, another member of Friendship Baptist Church, is the handy man on site. He put the finishing touches on the community garden sign his son painted that will stand over their "harvest trailer." He also built the raised flats for youth or those with disabilities.

Healthy food fits with his spiritual life, Miles said: "Body, mind and spirit. They all come together."

Calvin Miles paints Friendship Missionary Baptist's Friendship Garden sign on April 17. Miles' son painted the majority of the sign, while Miles added the finishing touches.

"When I see things like (Friendship Gardens) take offit's just everything," Laboy said.

But not every health ministry takes root as easily nor does every program.

Paula Williams chaired the board for the Boone County Minority Health Network until it disbanded last year. The network began in 2005 with the purpose of addressing health disparities. It ultimately died due to lack of funding.

"There was no full-time, dedicated staff to keep up with the grant writing," Williams said.

Live Well By Faith is on a two-year grant from the Boone County Commission, and Laboy is optimistic about getting it renewed. "I'm letting anyone out there that's doing this kind of work know that Verna is available to take this to the next level," she said.

There's one year left on the grant. Then, the Columbia/Boone County Department of Public Health and Human Services will re-apply. "We are just getting started," Laboy said.

She recognizes that it takes time to change a culture.

"We have to make different choices," she said. "We're living longer. Do you want to live in a nursing home? Do you want illness to take you out in such a way where someone who doesn't want to take care of you is forced to take care of you? It's a tough conversation to have, but someone has to put it out there."

Churches around Boone County are having that conversation. Laboy hopes "Cooking Matters" will be offered in 15 African-American churches in the upcoming year. Urban Empowerment Ministries has a Weight Watchers program with 22 members representing five different church communities.

Five other churches are interested in the upcoming "Eat Healthy, Be Active" program, Laboy said. She and six trained lifestyle coaches from those health ministries will be meeting to talk about bringing the curriculum to those five churches. The Columbia/Boone County Department of Public Health and Human Services has a "Shazzy Fitness" program that brings community members together to work out to gospel music.

"These are small ways we're chipping away at the health literacy and health consciousness of people," Laboy said.

Dorothy Slaughter removes weeds from her garden plot on the evening of April 17. The garden, a part of the Live Well By Faith program at Friendship Missionary Baptist Church, is open to community members to grow healthy produce to use in their meals.

"This is the hardest work I've ever done," Laboy said. "And it's taking care of myself. Why is that so hard to do? Because we're going against the grain; it's going against the culture," she said. "Great-grandma made the biscuits this way. Grandma made the greens this way. Mom makes the cobbler this way. So our tastes have adjusted, but it's killing us."

There are healthier ways of doing things, Simmons said. "You start developing a habit of being healthy rather than choosing the cake. It's been a long time since I've had cake, now. I want cake; I love cake! But it's an unhealthy choice."

Laboy shared similar sentiments. "You've got to be able to tell yourself no," she said.

"This is a lifestyle transformation change for me and I have to do it. If no one else does it, Verna has to show up for Verna."

Laboy shares her experiences on the Live Well By Faith Facebook page regularly, reminding those who are on the journey with her that they can succeed even if some days are hard. "Victory I make it to the gym this morning and boy was it a struggle. I wanted to quit!" she shared in a recent post.

"Setbacks are set-ups for a come back!" she wrote in an earlier post.

Campbell-Carter faced a setback as well. "I had to creatively regroup my workout plan when my (Activity and Recreation Center) membership expired last December," she said. Her insurance stopped reimbursing her for the membership, but she said she knew she wanted to stay active.

Campbell-Carter ultimately chose to start budgeting for weekend classes, and during the week she does yoga, gardening or goes on a "PRAYER walk," which is the term used in the Friendship Baptist health ministry to describe a neighborhood walk a group or individual can participate in. "It's great to feel increases in my muscle strength and tone. Also, I sleep so good at night," she said.

Laboy sees the proof at the gym, not just in herself but in others.

"When I'm at the gym working out and I see some of my diabetes self-management folks walking around on the track or working out on the equipment, my heart just smiles," she said.

But there's so much more to do."I can't just plant the seed and leave," Laboy said. "I have to keep coming back and watering it, and when I come, I'm coming with a tank of water and fertilizer."

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Smartphone-Controlled Cells Keep Diabetes In Check – IEEE … – IEEE Spectrum

Thursday, April 27th, 2017

Smartphones can already control homes and cars, anddiagnosediseases. Chinese and Swiss researchers now show that a smartphone can command engineered cells implanted in diabetic mice to produce insulin.

The researchers demonstrated a clever closed-loop system in which a digital glucometer transmits data on the rodents blood glucose levelsto a smartphone, which processes the data and then signals the implanted cells to deliver insulin.This is a step towards a new era of personalized, digitalized precision medicine, says Haifeng Ye of East China Normal University,who led the work reported in Science.

Cell-based therapies are a radical new medical treatment option being investigated by researchers. The idea is to turn cells into disease-fighting weapons by engineering them to produce therapeutic chemicals and proteins that they would churn out once implanted in the body. Living white blood cells, for instance, have been designed to fight cancer, HIV, and other diseases.Hundreds of cell therapies are undergoing clinical trials. But none can be controlled from outside the body.

Ye and his colleagues have come up with an innovative way to add smarts to cell-based therapy. They chose diabetes as the target disease.

They initially inserted light-sensitive bacterial proteins into mammalian cells. When exposed to far-red light (wavelength of about 730 nanometers), the protein activateda genetic pathway that causedthe cells to produce insulin.

After that success, they team made dime-sizedevices in which circular power-receiving coils surround a hydrogel that is embedded with the engineered cells and far-red LEDs. These devices were implanted under the skin of diabetic mice. When an external transmitting coil wirelessly switches on the LEDs via electromagnetic induction, their light triggers the cells to produce insulin in the animals.

The team made three things to remotely control the engineered cells: a custom-engineered Bluetooth-active glucometer,an Android-based smartphone app,and an intelligent control box that controls the power-transmitting coil.

When the researchers placemice blood samples on the glucometer, it sends measurements to the smartphone via Bluetooth. The phone app compares these levels to a pre-set threshold, then signals the control box to turn on the power-transmitter coil, which switches on the LEDs long enough for the cell implant to deliver the right amount of insulin.

The animals blood glucose typically went down to nondiabetic levels within two hours of irradiation. The system maintained the blood glucose concentration in mice for 15 days without any side effects. After that it could be replaced, Ye says, but a much longer performance or replacement frequency of the implant needs to be further investigated in humans.

One big limitation of the system is that it needs manual blood draws. Another is that the animals need to be close to the transmitting coil and be exposed to EM radiation to switch on the LEDs.

But a bit more engineering could yielda diabetesmonitoring-and-treatment system that isfully automatic and portable. A continuous glucose monitorcould send blood sugar measurements to the users phone. The phone would trigger a battery-powered LED wristband to shine light on the implanted insulin-producing cells.

IEEE Spectrums biomedical engineering blog, featuring the wearable sensors, big data analytics, and implanted devices that enable new ventures in personalized medicine.

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Smartphone-Controlled Cells Keep Diabetes In Check - IEEE ... - IEEE Spectrum

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Decrease in cardiovascular diseases benefits persons with diabetes … – Science Daily

Thursday, April 27th, 2017

The incidence of cardiovascular diseases in Sweden has decreased sharply since the late 1990s. These are the findings of a study from Sahlgrenska Academy which included almost three million adult Swedes. In relative terms, the biggest winners are persons with type 1 and type 2 diabetes.

"This is a huge improvement and a testament to the improvements in diabetes and cardiovascular care throughout Sweden," says Aidin Rawshani, medical doctor and doctoral student in molecular and clinical medicine.

The study, which was published in The New England Journal of Medicine, shows that the incidence of cardiovascular diseases and deaths among individuals with diabetes in Sweden dropped significantly between 1998 and 2014. The population in general exhibited the same trend, albeit to a smaller extent.

Among persons with type 1 diabetes, with an average age of 35 years, the incidence pf cardiovascular disease was reduced by 40 per cent during the period in question. In the control group of persons of similar age but without diabetes, the decrease was 10 per cent.

Among individuals with type 2 diabetes, with an average age of 65 years, the incidence of cardiovascular disease decreased by 50 per cent. Among control persons of similar age without diabetes, the decrease was 30 per cent.

Surprising results

"We were surprised by the results, specially for persons with diabetes. Some smaller studies in the past have indicated that numbers were improving, but nothing of this magnitude," says Aidin Rawshani.

In total, approximately 2.96 million individuals were studied, of which 37,000 had type 1 diabetes and 460,000 had type 2 diabetes. The results of the study are based on linked processing of data from the National Diabetes Register, the Cause of Death Register and the part of the Patient register that concerns inpatient care.

In addition to matching by age and gender, the groups that were compared were also matched geographically using register data from LISA (the longitudinal integration database for health insurance and labour market studies).

The deaths that took place in the groups during the study period were almost exclusively related to cardiovascular disease. Individuals with diabetes have previously shown to suffer a risk of cardiovascular disease and early death that was between two and five times as high as in the general population.

Better risk control

"One of the main findings of the study is that both deaths and the incidence of cardiovascular disease is decreasing in the population, both in matching control groups and among persons with type 1 and type 2 diabetes. One paradoxical finding is that individuals with type 2 diabetes have seen a smaller improvement over time regarding deaths compared to the controls, while persons with type 1 diabetes have made an equal improvement to the controls," notes Aidin Rawshani.

The positive trends that have been observed in the study are most likely due to an increased use of preventative cardiovascular medicines, advances in the revascularisation of atherosclerotic disease and improved use of instruments for continual blood sugar monitoring, and the fact that Swedish diabetes care has generally worked well with good treatment guidelines and quality assurance efforts.

"Out study and analysis does not include explanations of these trends, but we believe that it is a matter of better control of risk factors, better education patients, better integrated treatment systems for individuals with chronic illnesses and individual care for persons with diabetes. There is often an entire team working with a patient, ensuring that their needs are met," says Aidin Rawshani.

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Lilly Assures Market As Diabetes Stumbles – Seeking Alpha

Thursday, April 27th, 2017

As the diabetes wars have raged, Eli Lilly's (NYSE:LLY) balanced portfolio has helped insulate it from the share price losses dealt to competitor Novo Nordisk (OTCPK:NONOF). But even Lilly can have an off quarter.

Trulicity's growth was more than offset by below-consensus sales for Basaglar and Jardiance - the underperformance of the last of these was surprising given that it has begun marketing on its cardiovascular benefit. When combined with last week's US rejection of rheumatoid arthritis entry Olumiant, these disappointments forced Lilly executives to reassure investors that the company's medium-term guidance of 5% growth could still be met.

Lilly shares fell 3% today following the release of first-quarter results, removing $2.7bn in market valuation. Since the Olumiant complete response letter was announced, shares have fallen 6% (Olumiant setback opens the door to rivals, April 18, 2017).

Bernstein analyst Tim Anderson chalked up some of the losses to profit-taking - before the Olumiant news, shares were up 16% on the year - but acknowledged the effect of Olumiant and diabetes revenue on investor sentiment.

Topline good

In the long view, the Indiana-based group had a positive quarter, with revenue of $5.2bn and earnings per share of $0.98 in line with investor expectations. However, having just got over the news of Olumiant - rejected because of questions over the most efficacious dose and safety characterization - news that diabetes was not necessarily firing on all cylinders was not taken well.

Expectations for Jardiance remain high since it is the first of the SGLT2 class to be allowed to market on the basis of averting cardiovascular death in diabetics, although it could very well be chased by competitors Invokana, from Johnson & Johnson, and Farxiga, from Astrazeneca (NYSE:AZN) (ACC - Jardiance heart benefit looks like a class effect, March 20, 2017).

Lilly diabetes chief Enrique Conterno characterized the SGLT2 class as having flat growth before the cardiovascular data was included on the Jardiance label, but said that since marketing on that claim has begun new patient starts have risen 70% - the miss on Jardiance sales may simply reflect a mismatch between investor expectations and market realities.

Olumiant's bigger setback has investors questioning the 5% revenue growth forecast given that the drug is one of four new products that will post annual sales growth of $1bn or more to counteract losses due to patent expiries. Finance chief Derica Rice offered some comfort: "We've factored in that we won't have 100% success on every molecule" when preparing that forecast, he said.

Olumiant's failure to add US revenue does, however, increase the pressure on the rest of the portfolio to meet sales expectations. And Lilly's exposure to the volatile diabetes space raises the risk that that will not happen.

Editor's Note: This article discusses one or more securities that do not trade on a major U.S. exchange. Please be aware of the risks associated with these stocks.

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Lilly Assures Market As Diabetes Stumbles - Seeking Alpha

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One in 7 people in Nevada is living with diabetes, and the state is … – Yahoo Finance

Thursday, April 27th, 2017

(Sen. Yvanna Cancela speaks with Majority Leader Aaron Ford and diabetes patients.Courtesy Yvanna Cancela) The state of Nevada is taking a new approach to tackling the rising price of prescription drugs with a new bill.

The bill, introduced in March by state Senator Yvanna Cancela, has already faced opposition from lobbyists and nonprofit patient groups that disagree with the bill's approach to reining in prescription drug spending.

Nevada is one of 23 states with proposed legislation to take on the rising cost of prescription drugs. But unlike others that focus on drug prices in a general sense, Cancela's bill focuseson two specificgroups of drugs that are used to treat diabetes: insulin and biguanides.

It's the latest milestone in government actions at the local, state, and national levels that attempt to change the way wespend money on prescription drugs.

Diabetes is a group of conditions in which the body can't properly regulate blood sugar that affects roughly 30 million people in the US. And for many people living with diabetes including the1.25 million people in the US who have Type-1 diabetes injecting insulin is part of the daily routine.

insulin prices humalog novolog V2

(The list price of Humalog and Novolog, two short-acting insulins, over 20 years. The list prices don't factor in any rebates or discounts the drugmaker pays out.Andy Kiersz/Business Insider) Insulin, a hormone thathealthy bodies produce, has been used to treat diabetes for almost a century, though it's gone through some modifications. In the past few years, the list price of insulin has increased routinely.

The list price of the most commonly used insulins have increased roughly 300% over the last decade. Technically, there's no "generic" insulin, though a cheaper version of a long-acting insulin did come on the market in 2016. There are cheaper medications forbiguanides, such as metformin, which are used to treat Type-2 diabetes.

Before becoming a state senator, Cancela workedas a director for the Culinary Workers Union in Las Vegas, which represents about 60,000 workers. The union pays for its members health insurance through a self-funded trust, which Cancela told Business Insider gave the organization a lot of access to details about how its health funds were being spent. One of the drugs she noticed was becoming a problem for members was insulin.

There are roughly 281,000 adultsliving in Nevada, or 12% of the total population, that have one of the two types of diabetes, with another 39% in the prediabetes stage, in which blood glucose levels are elevated but not to the point of type-2 diabetes. Because diabetes is one of the biggest medical problems in Nevada, Cancela said, it made for a perfect starting point to introduce legislation.

The Nevada bill, known as SB265, takes four mainapproaches to confronting the drugmakers that make insulin and biguanides to treat diabetes.

Like most legislation that tries to rein in prescription drug spending, SB265 is facing its fair share of pushback and criticism.

Cancela said there's been around 70 lobbyists who have come in for the session to oppose the bill, which is more than double the number present for Nevada's 2015 session,according to The Nevada Independent. There's also been a number of patient groups that have spoken out as well, including those representing people with lupus and epilepsy.

"Proposed legislation in the Nevada State Senate unfairly targets people with diabetes, would be a major windfall for health insurance companies, and leaves patients wondering whos next," Lupus of Nevada said in a Facebook post. "Were specifically worried that Nevadans with Lupus could be singled out."

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(A Type 1 diabetes patient holds up bottles of insulin.Reuters/Lucy Nicholson) Nine pharmaceutical companies submitted lettersin opposition to the bill, as well as pharma's lobbying group PhRMA and biotech's lobbying group BIO. Many brought up their opposition to disclosingmore information about how they set their prices.

A letter from Novo Nordisk a company that manufactures insulin and other diabetes medications argued that the bill doesn't take into account the rebates drug companies pay out to middlemen. That issue was raised in a number of the letters opposing the bill.

"This proposal would impose significant new, complex and punitive requirements on drug manufacturers when manufacturers already provide competitive discounts to payers and represent only a single component of the enormously complex US drug pricing and distribution system," the company said in the letter. "This complexity, which the proposed legislation fails to address, has resulted in confusion around what patients pay for medicines."

To be sure, there's more to the story than just the list price a manufacturer sets. Along the way, there are as many as five companies that have a stake in the price of a medication. But there's a lack of transparency about the portion each player gets. To counter that, some drug companies have started disclosing their net prices, or the amount it actually receives in return for the drug after factoring in any rebates or discounts paid out to middlemen.

Sanofi noted in its opposition letter that its net price for Lantus, a long-acting form of insulin, fell over five years.

Sanofi said in a statement to Business Insider:

"Sanofi believes this legislation will fail to achieve its intended purpose and may actually restrict patients access to important medications. As a company founded on and committed to science and improving health, we understand that affordability and access to our products is critical for patients and society, and we are committed to working with all stakeholders to ensure patients have affordable access to the treatments they need in a system that is sustainable and continues to promote ongoing investments in science and innovation."

Others, like Ken Thorpe, the chairman of the Partnership to Fight Chronic Disease (a group that partners witha number of healthcare companies and patient organizations) and a health policy professor at Emory University, criticizedthe idea that the bill is a way to help those living with diabetes. He argued in a piece in the Nevada Appeal that the price capswon't keep people from getting diabetes.

"If they're really trying to get the cost of healthcare to grow at a slower rate, this is not the way," he told the Appeal. Instead, he said, there should be more of a focus on preventing diabetes.

Cancela said that's something she's working on as well, calling SB265 "one piece of the puzzle." She has another piece of legislation that would promote urban agriculture to increase access to healthy foods in low income communities.

The bill is still with the Health and Human Services committee, meaning it needs to clear the Assembly and Senate before it makes its way to the governor.

But of course, drug price bills have failed in the past. In November 2016, Californians voted against a proposition that would've capped prescription drug prices at what the Department ofVeterans Affairs pays for them.

Cancela understands that it's not going to be an easy ride.

"We're trying to do something that's never been done before," Cancela said.

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One in 7 people in Nevada is living with diabetes, and the state is ... - Yahoo Finance

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Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027 … – Yahoo Finance

Thursday, April 27th, 2017

DUBLIN--(BUSINESS WIRE)--

Research and Markets has announced the addition of the "Type 1 Diabetes Mellitus Forecast in 12 Major Markets 2017-2027" report to their offering.

Type 1 Diabetes Mellitus (T1DM) is a multisystem disease that progressively destroys the pancreas' ability to produce insulin. This leads to a chronic condition of defective metabolism of fat, carbohydrates and proteins due to the lack of insulin. It occurs mainly in childhood and adolescents, however a rising number of latent autoimmune diabetes of adulthood (LADA) cases have been reported mainly due to a better understanding and diagnosis of the disease.

This report provides the current prevalent population for Type 1 Diabetes Mellitus across 12 Major Markets (USA, Canada, France, Germany, Italy, Spain, UK, Brazil, Japan, India, China and Russia) split by gender and 5-year age cohort. Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and prognosis along with specific variations by geography and ethnicity.

Providing a value-added level of insight from the analysis team, several of the main symptoms and co-morbidities of Type 1 Diabetes Mellitus have been quantified and presented alongside the overall prevalence figures. These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.

Reasons to Buy:

- Able to quantify patient populations in global Type 1 Diabetes Mellitus market to target the development of future products, pricing strategies and launch plans.

- Gain further insight into the prevalence of the subdivided types of Type 1 Diabetes Mellitus and identify patient segments with high potential.

- Delivery of more accurate information for clinical trials in study sizing and realistic patient recruitment for various countries.

- Provide a level of understanding on the impact from specific co-morbid conditions on Type 1 Diabetes Mellitus prevalent population.

- Identify sub-populations within Type 1 Diabetes Mellitus which require treatment.

- Gain an understanding of the specific markets that have the largest number of Type 1 Diabetes Mellitus patients.

Key Topics Covered:

1. Introduction

2. Cause of the Disease

3. Risk Factors & Prevention

4. Diagnosis of the Disease

5. Variation by Geography/Ethnicity

6. Disease Prognosis & Clinical Course

7. Key Comorbid Conditions/Features associated with the disease

8. Methodology for quantification of patient numbers

9. Top-line Prevalence for Type 1 Diabetes Mellitus

10. Features of Type 1 Diabetes Mellitus Patients

10.1 Comorbidities and Sequelae in T1DM Patients

10.2 T1DM patients with Retinopathy

10.3 Prevalence of T1DM defining antibodies

11. Abbreviations used in the report

12. Patient-Based Offering

13. Online Pricing Data and Platforms

14. References

15. Appendix

For more information about this report visit http://www.researchandmarkets.com/research/j3bqpv/type_1_diabetes

View source version on businesswire.com: http://www.businesswire.com/news/home/20170427005670/en/

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Scientists in Texas closer to diabetes cure with unconventional treatment – icFlorida

Tuesday, April 25th, 2017

by: Marty Toohey, American-Statesman Staff Updated: Apr 24, 2017 - 9:52 PM

SAN ANTONIO, Tx. - Years of testing remain, but UT Health San Antonio researchers say theyve cured Type 1 diabetes in mice.

In peer-reviewed paper, they say a gene transfer can wake up cells in the pancreas to produce insulin.

>> Read more trending news

Health researchers at the University of Texas think they have found a way to trick the body into curing Type 1 diabetes.

The immune system of a person with diabetes kills off useful beta cells, but the UT researchers say they have found a way to make other cells in the pancreas perform the necessary work. Their approach, announced earlier this month in the academic journalCurrent Pharmaceutical Biotechnology, not only would have implications for Type 1, formerly called juvenile diabetes, but also could help treat the far more common Type 2 variety, also known as adult-onset diabetes.

The researchers have cured mice, which are genetically similar to people but different enough that new rounds of animal testing and millions of dollars more are needed before human trials can begin. The researchers approach is sure to garner skeptics, at least in part because it is a significant departure from the many other attempts at curing diabetes, which typically involve transplanting new cells and/or suppressing the immune systems attempts to kill off useful ones.

By contrast, were taking a cell that is already present in the body its there, and its happy and programming it to secrete insulin, without changing it otherwise, said Ralph DeFronzo, chief of the diabetes research at the UT Health Science Center at San Antonio.

Diabetes is a disease characterized by a persons inability to process carbohydrates, a condition that if untreated can lead to often-catastrophic health consequences: lethargy, diminished eyesight, heart attacks, strokes, blindness and a loss of circulation in the feet that could lead to amputation. The Centers for Disease Control and Preventionestimate that in 2014, about 29 million Americans almost 1 in 10 had diabetes.

The core problem is insulin. Most people naturally secrete that substance when they eat something with carbohydrates, such as bread, potatoes and candy bars. Insulin acts like a concierge that escorts the sugar from the bloodstream into the cells, providing the cells with the energy to function. In most people, the body is continually monitoring blood sugar and producing insulin as needed.

In Type 2 diabetes which makes up 9 out of 10 diabetes cases and is generally associated with older people and weight gain the cells reject the insulin, causing sugar to build up in the bloodstream even as cells are starved for energy. Type 2 is often treated with pills that tell the cells to let in the insulin. But in Type 2 diabetes, the body also often gradually loses the ability to produce insulin, requiring insulin injections.

In Type 1 the type the researchers studied the body has simply stopped producing insulin. This type often manifests in children, though it can sometimes develop in adults as well.

The reason the body stops producing insulin is that it kills off the pancreas beta cells, which produce insulin. People with Type 1 diabetes must get their insulin from injections or ingestion, a cumbersome and often imprecise task. Too little insulin and blood sugar levels stay high for extended periods, potentially damaging the body; too much and blood sugar levels crash, possibly causing a person with diabetes to faint or experience an even worse problems, such as a stroke.

DeFronzos partner, Bruno Doiron, decided to see whether the body could reliably produce insulin without transplanting new cells. He used a gene transfer technique on mice, delivered via a virus, that activated insulin production in cells already in the pancreas for instance, those that produced certain enzymes.

Were not fundamentally changing the cell, DeFronzo said. Were just giving it one additional task.

The mice immune systems did not attack the new insulin-producing cells. Most important, according to the findings: The cells produced the right amount of insulin: not so much that they sent a mouse into a blood sugar free fall, not so little that blood sugar levels stayed high. The mice have shown no sign of diabetes for more than a year, according to the findings.

Quite a bit of work remains before testing will start on people. If they can raise enough money they estimate $5 million to $10 million they can proceed to testing on larger animals, such as pigs, dogs or primates, a next step that would be planned in conjunction with the U.S. Food and Drug Administration.

They hope to start human trials in three years.

DeFronzo and Doiron said they expect skepticism but said much of it will be driven by how unconventional their work is. Doiron added that, although the technique is unconventional in the context of diabetes, using a virus to deliver a gene transfer is an established technique, having been approved dozens of times by the FDA to treat diseases.

We can use the cells the body has naturally, Doiron said. This will simply wake up the cells to produce insulin.

Type 1 and Type 2 diabetes

The work of Bruno Doiron and Ralph DeFronzo focuses on Type 1 diabetes, not Type 2.

Both diseases involve a problem with insulin, the substance that healthy bodies produce to take sugar from the bloodstream into the cells and power the body.

Type 2 is far more common. The main issue is that the cells reject insulin, causing sugar to build up in the bloodstream. The common treatment is a pill that makes the cells accept the insulin (and sugar it carries into the cell). But over time, people with Type 2 diabetes often lose the ability to produce insulin.

With Type 1 diabetes, people simply stop producing insulin. Their bodies kill off the cells in the pancreas that produce it.

Those with Type 1 diabetes must inject or ingest insulin. People with Type 2 often grow increasingly dependent on insulin injections, though Type 2 can sometimes be cured or controlled through diet and exercise.

2017 Cox Media Group.

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Scientists in Texas closer to diabetes cure with unconventional treatment - icFlorida

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Diabetes may cause more deaths than previously thought – The Messenger (subscription)

Monday, April 24th, 2017

Four times as many deaths may be caused by diabetes, according to a recent study by Boston University School of Public Health published in the online journal PLOS One.

The study argued that diabetes caused 12 percent of deaths in the U.S. Currently, death certificates indicate that 3.3 percent of deaths in the U.S. are caused by diabetes. If the studys findings prove to be accurate, diabetes would become the third-leading cause of death in the United States, up from the seventh.

According to the Kentucky Behavioral Risk Factor Surveillance Survey, diagnosed diabetes among adults nearly doubled in Kentucky from 6.5 percent to 12.5 percent from 2000 to 2014. Now, one in eight Kentucky adults, or 424,670 people in Kentucky are estimated to have diagnosed diabetes.

In 2015, the rate of diabetes increased again to 13.4 percent. Nationally, nearly 10 percent of people have diabetes.

The Centers for Disease Control estimates 138,000 Kentuckians are living with undiagnosed diabetes.

The Pennyrile region of Kentucky has a comparatively average rate of diabetes, at 12.1 percent. Regions along the eastern part of Kentucky have rates as high as 17.8 percent.

It was surprising to me that they would put it at 3 percent, said Christian County Health Department Nurse Jennifer Boone. Diabetes is just so hard on the entire body. It effects the entire body. All the organ systems, everything.

Diabetes is a group of diseases in which high levels of blood sugar are found in the body for extended periods of time.

Type 1 Diabetes comes from the pancreas failing to produce enough insulin. Type 2 Diabetes is usually caused by obesity and inactivity, when the body does not respond to insulin properly. Type 2 Diabetes usually occurs in later stages in life and is considered a result of lifestyle choices.

Its a lifelong thing. A lot of people think that if they eat healthy, if they exercise, if they are able to come off their medication then they dont have diabetes, Boone said. Its not like its ever really cured. Its just managed well.

Diabetes can cause kidney failure. It can also cause blindness, as the blood vessels in the eye can become damaged by the high amount of blood sugar caused by diabetes.

Gums can also become infected and inflamed by diabetes.

Any open wounds take longer to heal with diabetes, leading to many festering sores for those who suffer from the disease.

Kentucky has the 12th highest mortality rate in America. Exercise and a good diet are considered to be good forms of diabetes prevention.

People with higher than average blood sugar levels are considered to have prediabetes. Those with that condition can prevent diabetes with exercise and a good diet.

The Christian County Health Department advocated for the expansion of the Hopkinsville Greenway System during the debate over H-CC WINS, because the organization believed that the system would promote walking in the community, which would lead to better health.

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Diabetes may cause more deaths than previously thought - The Messenger (subscription)

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Becton Dickinson Aims Beyond Diabetes with $24B Bard Deal – Xconomy

Monday, April 24th, 2017

Xconomy New York

In a medical technology merger with implications for the healthcare sector in the United States and beyond, Becton Dickinson is acquiring C.R. Bard for $24 billion to tap into the growing markets for products used in treating vascular conditions and cancer.

Under the deal announced Sunday, Franklin Lakes, NJ-based Becton Dickinson (NYSE: BD) will pay Bard (NYSE: BCR) shareholders approximately $222.93 in cash and 0.5077 shares of BD stock per Bard share. That represents $317 for each Bard share, a 25.2 percent premium over Bards closing stock price Friday. When the deal closes, shareholders of Murray Hill, NJ-based Bard will own approximately 15 percent of the combined company.

BDs $12.4 billion in revenue last year was split between its Medical Segment, which makes diabetes care products and devices used by clinicians to manage and administer medication, and its Life Sciences Segment that sells products for collecting and transporting diagnostic specimens. The company says that Bard will help it expand beyond diabetes into areas such as peripheral vascular disease, urology, hernia, and cancer.

Bard operates four business units: oncology, vascular, urology, and surgical specialties. Vascular products made up more than $1 billion of the companys $3.7 billion in 2016 revenue, edging out oncology as the companys largest business unit. BD says that bringing Bards vascular products, such as catheters and ports, together with its devices that prepare, dispense, and administer drugs will help the combined entity address a wider range of medication management needs. BD, which conducts its research and development work in Research Triangle Park, NC, also says that the two companies together can offer a more comprehensive lineup of products addressing surgical site infections and catheter-related blood stream infections.

Both companies generate most of their revenue from U.S. customers, but BD notes that Bards head start in international markets, with about 500 products already registered for sale overseas, was attractive.

The combined company will have a large and growing presence in emerging markets, including $1 billion in annual revenue in China, BD said in a prepared statement.

The medical device sector has experienced a flurry of activity in recent years. In 2015, Medtronic (NYSE: MDT) closed on its acquisition of Mansfield, MA-based Covidien for $49.9 billion in cash and stock. Later that year medical device giant Zimmer acquired its Warsaw, IN, neighbor Biomet in a $13.35 billion cash and stock deal that formed Zimmer Biomet (NYSE: ZBH).

BDs Bard deal comes two years after it closed its $12.2 billion acquisition of San Diego-based CareFusion. CareFusion brought to BD its lineup of devices used for administering and managing medication, which were integrated into the New Jersey companys medical division. With the Bard acquisition, BD plans to create a third business unit called BD Interventional. BD says that Tom Polen, who is executive vice president of the BD Medical Segment, will become president of BD, effective immediately. In his new role, Polen will oversee all three of BDs business segments.

The boards of directors of both BD and Bard have approved the deal. The companies expect the acquisition to close in the fall of this year.

Photo by Flickr user Tareq Salahuddinvia a Creative Commons license.

Frank Vinluan is editor of Xconomy Raleigh-Durham, based in Research Triangle Park. You can reach him at fvinluan [at] xconomy.com

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Russia Diabetes Market Report: 2017 – 2022 – Research and Markets – Yahoo Finance

Monday, April 24th, 2017

DUBLIN--(BUSINESS WIRE)--

Research and Markets has announced the addition of the "Russia Diabetes Market Report: 2017 - 2022" report to their offering.

Russia Diabetes Market Report: 2017 - 2022 provides an analytical and statistical insight into the Russia diabetes market. The report provides both current and future trends in the prevalence, demo-graphical breakup, diagnosis and treatment of diabetes in Russia.

The research study serves as an exceptional tool to understand the epidemiology, market trends, therapeutic structure, competitive structure and the outlook of the Russia diabetes market. This report can serve as an excellent guide for investors, researchers, consultants, marketing strategists and all those who are planning to foray into the Russia diabetes market in any form.

Scope of the Report:

Comprehensive situation analysis of the Russia diabetes epidemiology and its dynamics:

Comprehensive situation analysis of the Russian Oral Antidiabetics market and its dynamics:

Comprehensive situation analysis of the Russian Insulin market and its dynamics:

Key Topics Covered:

1 Preface

2 Research Methodology

3 Executive Summary

4 Introduction

5 Diabetes Disease Overview

6 Russia Diabetes Epidemiology

7 Russia Diabetes Market

For more information about this report visit http://www.researchandmarkets.com/research/633bdx/russia_diabetes

View source version on businesswire.com: http://www.businesswire.com/news/home/20170424005826/en/

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Russia Diabetes Market Report: 2017 - 2022 - Research and Markets - Yahoo Finance

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