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Harvey Weinstein hobbled into Manhattan court Friday looking pallid and unsteady thanks to severe diabetes and a spine condition, sources told The Post.

The 67-year-old accused rapist and former powerhouse Hollywood producer who was in court for a new bail hearing has suffered from Type 2 diabetes, back issues and other health problems that have been in free-fall since his arrest, sources said.

Weinsteins health problems paved the way for him to be allowed to wear a modified monitoring device while hes out on bail awaiting trial on sex charges and the gadget was at the heart of Fridays hearing.

Weinstein who had a handler help prop him up as he entered the courtroom was originally outfitted with a regular ankle bracelet, but because of his health issues, bail bondsman Ira Judelson swapped it out for a two-part device. The new device includes a slimmer ankle bracelet with a separate signaling component. The original device is not prone to the same user error.

The one-piece device was problematic for his leg and medical issues, Weinsteins lawyer, Donna Rotunno, told the court of the original, much bulkier monitor.

But Assistant DA Joan Illuzzi-Orbon said Weinsteins ankle monitor was untraceable on at least 56 separate occasions, in violation of his bail conditions. Prosecutors said Weinstein repeatedly failed to keep within range as required.

Due to the violations and new bail reform laws taking effect next year, Weinsteins bail package has to be re-examined, with both sides making their arguments Friday. Justice James Burke is set to rule on the issue Wednesday.

Weinstein is currently free on $1 million cash bail. He faces up to life in prison on charges of predatory sexual assault, criminal sex act and rape in connection with three accusers.

Matthew McDermott

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Harvey Weinstein's diabetes and spine condition to blame for his appearance - Page Six

By studying the nematode Caenorhabditis elegans, scientists from Vanderbilt University and the University of Michigan have identified a protein that's key for insulin synthesis, the understanding of which they say could lead to new approaches to prevent and treat Type 2 diabetes.

The protein, called TRAP-alpha, is widely shared across worms, flies and mammals, including humans. In a study published in the journal Science Advances, the team showed that TRAP-alpha is required for insulin production, corroborating previous knowledge that alterations in the TRAP-alpha gene are linked to the development of diabetes.

The researchers made the discovery while screening for genetic clues to the PI3K/Akt signaling pathway that may contribute to reduced insulin signaling. Irregularities in the PI3K/Akt pathway have been linked to many human diseases, including cancer, cardiovascular disease anddiabetes.

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The screens turned up TRAP-alpha. The protein is part of a complex known as translocon that helps moveor translocatenewly synthesized proteins into the endoplasmic reticulum (ER) of cells for further processing before theyre eventually secreted.

The researchers discovered that deletingthe C. elegans equivalent of TRAP-alpha affects the worms' insulin signaling pathway.

They went on to delete TRAP-alpha in insulin-making pancreatic beta cells of rats. Doing so led to a sharp decline in total insulin, the team found. Preproinsulin, the precursor molecule to insulin, was not properly transferred into the ER for final processing, so most of it was degraded.

TRAP-alpha was not on anyone's radar in terms of being required for insulin biogenesis, Patrick Hu, the studys senior author, said in a statement. Our work highlights the value of using a model organism likeC. elegansto do an unbiased genetic screen. It led us to a molecule that seems to be important in making insulin and that could very well shed light on the pathogenesis of diabetes, a common disease that affects about 10% of the U.S. population.

RELATED:Subtle chemical shift reverses prediabetes in Merck-partnered mouse trial

Given the prevalence of diabetes, several research groups are also working on new ways to tackle it. Scientists from the University of Utah, in collaboration with Merck Research Laboratories, recently prevented or reversed prediabetes in mice. They did it by shutting down an enzyme called DES1 to reduce the amount of fatty lipid ceramides, which is key in metabolic health.

A team at the University of Geneva treated Type 1 diabetes in mice byconverting non-insulin-producing alpha and gamma endocrine cells into beta cells with the help of two transcription factors, PDX1 and MafA.

Understanding TRAP-alpha could inspire new ideas to prevent or treat Type 2 diabetesand maybe even more diseases, Hu and colleagues argued.

In the current study, the researchers noticed TRAP-alpha plays a role in promoting ER homeostasis, or the balance between incoming proteins and ER the proteins that help fold them. Loss of TRAP-alpha may cause ER stress, which can lead to cell death, the team reported.

Preproinsulin is the first client protein for TRAP-alpha to deliver into the ER for processing, and the scientists hope to find more like it.

It's likely other secreted molecules besides insulin might be affected by TRAP-alpha deletion, Hu said in a statement. If we can understand the broader role that TRAP-alpha is playing in maintaining protein homeostasis, we might develop new ways to approach other diseases, too.

More:
How worms revealed a key protein in insulin synthesis and diabetes - FierceBiotech

MUMBAI: There is some good news for the over 72 million diabetics in India, with a cheaper version of a blockbuster drug hitting the market on December 10. The domestic pharmaceutical market is abuzz with news of over 15-20 companies launching generic versions of the widely-prescribed anti-diabetic drug Vildagliptin, with its price expected to crash by half.

The potential of more affordable diabetic care comes in the wake of Swiss major Novartis-owned Vildagliptin losing patent on Monday a development closely watched for months. Dozens of companies have readied plans to get a slice of the action in the growing Rs 14,000-crore diabetes therapy market, with the number of players expected to cross 50 soon.

With the drugs patent expiry, the price may drop to Rs 6 per tablet over the next few months, from the existing Rs 20-25 each. What makes the patent expiry significant for Indian pharma is that Vildagliptin is the first among the gliptins, a relatively new class of oral diabetes drugs, to get off the block, and also the first diabetes medicine whose end of patent life is being seen by industry. Vildagliptin is a part of a class of diabetes medications called dipeptidyl peptidase IV or DPP4 inhibitors.

The innovator brand Galvus (along with combination of Metformin) cornered around Rs 600 crore, a lions share of total Vildagliptin market of Rs 950 crore (moving annual total (MAT) November 2019). The company also has agreements with USV, Cipla and Abbott, with their brands Jalra, Vysov and Zomelis respectively available in 50mg Vildagliptin, and in combination with Metformin.

Days before the launch, the market started hotting up with Mumbai-based Eris Lifesciences acquiring Zomelis from Novartis for around Rs 100 crore, and USV reportedly being in talks to acquire Jalra. When contacted, a Novartis spokesperson said, When patents expire, high-quality generics help lower the overall cost of healthcare and improve access to medicines for societies around the world, in a circle of discovery, development, commercialisation and loss of market exclusivity. We will continue to serve people living with diabetes through the innovator molecule in India, Galvus.

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Diabetes treatment to cost less on cheaper version - Times of India

In the last 21 years, I have been working closely with young women who have type 1 or type 2 diabetes and many of them have voiced a persistent concern and fear: will they be able to lead a fulfilling life as wives and mothers. They seem to have received little or no reassurance from family and friends. Social discrimination, misconceptions and stigma are still creating psychological and emotional problems for these young women.Research shows that societal stigma, shaming or discrimination of people with diabetes has a negative impact on patient self-care and leads to poor treatment outcomes.[i] Women face much more of this than men. They are deemed unfit for marriage and motherhood. They face this stigma on all fronts: from their own family, extended relatives, colleagues at work and from prospective spouses and their families.I would like to clear some of these misconceptions and send out a message of hope and reassurance to these young women.Never assume, always ask the doctorLack of understanding is the source of this stigma, both in rural and urban India. Poor understanding of the disease at all levels - patients, families, prospective in-laws, co-workers - creates a web of fear about the disease, its risks and its impact on everyday living. So many families assume no one wants to wed their daughter, because she has a lifelong chronic condition. They also assume that the young woman will be unable to bear children, and if she does, the child will be at risk of developing diabetes at some point in life.

In light of this, it becomes the doctors responsibility to guide patients and their families, give them the information they need on general diabetes management and particularly on pre and post-natal diabetes care. Patients need to be told that while diabetes does increase the risk of certain complications, advancements in medicine and technology have made these well manageable today.

Do not hide your condition, and never neglect your medicationI have met several young women patients in the process of finding a marriage partner, struggling with the dilemma of whether to tell their prospective partners and families about their diabetes status. Many have reported that when they did open up about their condition soon after marriage, they were advised to seek alternative medical treatment by their husbands and in-laws and asked to give up insulin therapy! Hiding the fact that they have diabetes has also led to an erratic medication schedule leading to horrifying results. Many patients developed a condition called ketoacidosis (excess blood acids called ketones) and needed to be rushed to the emergency room.

One of my biggest concerns is that newly diagnosed patients sometimes keep their diabetes status a secret from even their immediate family and colleagues for fear of judgement. Some of my new patients admit to taking their insulin or checking their blood sugar only in the privacy of their washroom, and do not do so as often as recommended if they are in a public place.

My message to patients here is simple: no person and no circumstance must ever trump your own health. Neglecting to monitor your blood sugar or to take your medication as prescribed, can put you at high risk of many complications, some of which are life threatening. Patients on insulin therapy should ask their doctor to help pick an insulin type that suits their daily schedule and body requirements.

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Message to young women with diabetes: Marriage and children, you can have it all! - Times of India

Laurel Bloomfield of Rigby is a contributing author for a new book targeted to entrepreneurs. | Courtesy photos

RIGBY Laurel Bloomfield of Rigby is an entrepreneur, inventor, mother and wife, and she will soon add author to her list of accomplishments.

She is one of 71 authors who will be featured in Air Fryer Secrets. Its not a cookbook rather, its an anthology providing business-building tips and strategies. Each chapter was written by a different author and caters to a specific niche in the marketing and entrepreneurial space.

Everything you would need to start an online business today is covered in the book, Bloomfield tells EastIdahoNews.com.

Bloomfields contribution is a chapter about intellectual property and how a product developer can write their own patent. She co-created a product with Nicholle Peterson and Katie Larsen several years ago designed to help those with Type 1 diabetes who wear an insulin pump. Its a pocket thats placed in the lining of clothing to hide it from view and keep it safe from damage.

RELATED | Local moms design a trendy way to carry insulin pumps

If you send a 5-year-old kid to school with a $10,000 pump, and they try to use the bathroom, it could fall in the toilet. Other kids have cut the tubing thats hanging out of their shirt going from the pump to the infusion site. That can be a life-threatening situation, Bloomfield says.

Her pocket helps keep that device safely up against their body and holds all the tubing in place to avoid all risks of danger. The pocket also gives kids a way to hide their condition so they do not become a spectacle to people around them, she says.

I think thats important for kids dealing with Type 1 diabetes. Sometimes theyre expected to be the spokesperson for this huge disease just because they have this noticeable thing (on their body). The pocket allows them to just be kids, says Bloomfield.

Bloomfields pocket concept gained a lot of traction from some of the leading insulin pump manufacturers in the world. It was put on the market about three years ago once her fully-issued patent was approved. Today, its sold online and in stores under the name Pocket Innerware.

Boise resident Kevin Quinn, the lead author of Air Fryer Secrets, has worked with Bloomfield on numerous development projects. Hes a software developer and a partner at a CBD company, among other things. He invited her to share her expertise with readers for this book.

The inspiration for the book came from a series of live Facebook videos Quinn began posting about eight months ago.

I wanted to show folks what I could cook in the air fryer one Friday. It was funny. People tuned in and had some fun with it. Then it started to grow and people started to ask What are you cooking for Fryer Friday?' Quinn says.

The initial post was intended as a joke, but it quickly went viral and eventually became a weekly bit called Fryer Friday.

The videos have since become a Facebook engagement tool to help build an audience for many of his business projects. The title of the book is a play on words intended to convey its central message of putting yourself out there to build brand awareness.

You need to decide who your audience is that you want to sell to, and then find a unique way to sell to them, Quinn says. This book will give them so many ideas (on) how to do that.

Bloomfield and Quinn recently launched a business together called Launch Incubator, which helps entrepreneurs find an audience for their product.

Bloomfield says she is excited to be able to offer marketing strategies and other resources for current and prospective business owners.

Its kind of like a digital marketing Bible. Its something that, when I got into this space 18 months ago, I wish I wouldve known more about, Quinn says.

Air Fryer Secrets will be available to buy through Amazon on Dec. 19. Visit the website to learn more.

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She invented a product to help those with Type 1 diabetes, and she's featured in a new book - East Idaho News

People with obesity, high blood sugar, high blood pressure or high cholesterol are often advised to eat less and move more, but our new research suggests there is now another simple tool to fight off these diseases: restricting your eating time to a daily 10-hour window.

Studies done in mice and fruit flies suggest that limiting when animals eat to a daily window of 10 hours can prevent, or even reverse, metabolic diseases that affect millions in the U.S.

We are scientists - a cell biologist and a cardiologist - and are exploring the effects of the timing of nutrition on health. Results from flies and mice led us and others to test the idea of time-restricted eating in healthy people. Studies lasting more than a year showed that TRE was safe among healthy individuals. Next, we tested time-restricted eating in patients with conditions known collectively as metabolic syndrome. We were curious to see if this approach, which had a profound impact on obese and diabetic lab rats, can help millions of patients who suffer from early signs of diabetes, high blood pressure and unhealthy blood cholesterol.

Its not easy to count calories or figure out how much fat, carbohydrates and protein are in every meal. Thats why using TRE provides a new strategy for fighting obesity and metabolic diseases that affect millions of people worldwide. Several studies had suggested that TRE is a lifestyle choice that healthy people can adopt and that can reduce their risk for future metabolic diseases.

However, TRE is rarely tested on people already diagnosed with metabolic diseases. Furthermore, the vast majority of patients with metabolic diseases are often on medication, and it was not clear whether it was safe for these patients to go through daily fasting of more than 12 hours as many experiments require or whether TRE will offer any benefits in addition to those from their medications.

In a unique collaboration between our basic science and clinical science laboratories, we tested whether restricting eating to a 10-hour window improved the health of people with metabolic syndrome who were also taking medications that lower blood pressure and cholesterol to manage their disease.

We recruited patients from UC San Diego clinics who met at least three out of five criteria for metabolic syndrome: obesity, high blood sugar, high blood pressure, high level of bad cholesterol and low level of good cholesterol. The patients used a research app called myCircadianClock, developed in our lab, to log every calorie they consumed for two weeks. This helped us to find patients who were more likely to spread their eating out over the span of 14 hours or more and might benefit from 10-hour TRE.

We monitored their physical activity and sleep using a watch worn on the wrist. As some patients with bad blood glucose control may experience low blood glucose at night, we also placed a continuous glucose monitor on their arm to measure blood glucose every few minutes for two weeks.

Nineteen patients qualified for the study. Most of them had already tried standard lifestyle interventions of reducing calories and doing more physical activity. As part of this study, the only change they had to follow was to self-select a window of 10 hours that best suited their work-family life to eat and drink all of their calories, say from 9 a.m. to 7 p.m. Drinking water and taking medications outside this window were allowed. For the next 12 weeks they used the myCircadianClock app, and for the last two weeks of the study they also had the continuous glucose monitor and activity monitor.

After 12 weeks, the volunteers returned to the clinic for a thorough medical examination and blood tests. We compared their final results with those from their initial visit. The results, which we published in Cell Metabolism, were pleasantly surprising. We found most of them lost a modest amount of body weight, particularly fat from their abdominal region. Those who had high blood glucose levels when fasting also reduced these blood sugar levels. Similarly, most patients further reduced their blood pressure and LDL cholesterol. All of these benefits happened without any change in physical activity.

Reducing the time window of eating also had several inadvertent benefits. On average, patients reduced their daily caloric intake by a modest 8%. However, statistical analyses did not find strong association between calorie reduction and health improvement. Similar benefits of TRE on blood pressure and blood glucose control were also found among healthy adults who did not change caloric intake.

Nearly two-thirds of patients also reported restful sleep at night and less hunger at bedtime similar to what was reported in other TRE studies on relatively healthier cohorts. While restricting all eating to just a six-hour window was hard for participants and caused several adverse effects, patients reported they could easily adapt to eating within a 10-hour span. Although it was not necessary after completion of the study, nearly 70% of our patients continued with the TRE for at least a year. As their health improved, many of them reported having reduced their medication or stopped some medication.

Despite the success of this study, time-restricted eating is not currently a standard recommendation from doctors to their patients who have metabolic syndrome. This study was a small feasibility study; more rigorous randomized control trials and multiple location trials are necessary next steps. Toward that goal, we have started a larger study on metabolic syndrome patients.

Although we did not see any of our patients go through dangerously low levels of glucose during overnight fasting, it is important that time-restricted eating be practiced under medical supervision. As TRE can improve metabolic regulation, it is also necessary that a physician pays close attention to the health of the patient and adjusts medications accordingly.

We are cautiously hopeful that time-restricted eating can be a simple, yet powerful approach to treating people with metabolic diseases.

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Limited eating times could be a new way to fight obesity and diabetes - The Conversation US

Over 400 million individuals worldwide, according to the World Health Organization (WHO), have diabetes, living each day on the precipice of health determined by the level of sugar in their bloodstream. The vigilance required to ensure that their levels are neither too high nor too low can often become all-encompassing. A circumstance that Lonny Stormo, co-founder and CEO of the Oak Park Heights, Minnesota-based startup, Pops, truly understands.

Lonny Stormo, Co-founder and CEO of Pops

Stormo brought his proficiency in electrical engineering and business to the medical device industry over three decades ago. He has served in various executive leadership roles during his thirty-year career at industry giant Medtronic, and even collaborated with NASA. Though his work at Medtronic was primarily focused on cardiovascular health, he developed a vested interest in diabetes care when, in his mid-thirties, Stormo was diagnosed with adult onset type 1 diabetes.

As an active member of his community and an avid runner, Stormo was often frustrated by the encumbrance that conventional blood sugar monitoring would have on his lifestyle. After fifteen years of observing the same testing and tracking regimen, this medical device industry veteran began to question whether there was a better way to do this.

How can it be with all the advances we were making in medicine, that I had been managing my diabetes the same exact way these years, with the same black zip-up bag holding a meter and test strips and a lancing tool that you had to assemble, says Stormo, describing the equipment that those with diabetes typically use to keep track of their daily blood sugar levels, The test kit was too big to carry around wherever I went. Besides, I was not comfortable taking everything out to run a test in front of everybody and often there would not be a table around for me to set things up on. It was all very inconvenient.

Stormo suggested that because of the inconvenience associated with this cumbersome approach, many with diabetes, as he often did, would just leave their test kits at home. Beyond seeing their blood sugar level results perhaps, a couple times a day while at home, many do not have any idea what their true status is. That is, until the next biannual medical exam when the HbA1C test that indicates the prior months blood sugar level average, is performed. By then, if the readings suggest their blood sugar concentration has been too high, any deterioration to their health that could result may have already taken place.

Poor self-monitoring of blood sugar levels over time is a leading cause of long-term health complications for those with diabetes complications that range from nerve damage, vision loss, kidney failure, heart attacks, stroke and lower limb amputation to death. According to the most recent report from the International Diabetes Foundation (IDF) citing data for 2017, approximately four million deaths globally were attributed to known cases of diabetes, thus placing it among the top ten causes of mortality worldwide (WHO 2018). Associated healthcare costs, in 2017 alone, amounted to $727 billion USD globally of which 48% was attributed to individuals living in the United States. Americans with diabetes spent on average $12,000 USD on health care in 2017, which is twice the cost incurred by those who live without diabetes (numbers taken from IDF 2017 report).

Stormo recognized that the struggles he faced managing his own care reflected the experience of millions of others in the US and is implicated in the high health care costs for those with diabetes. So, he decided to do something about it.

He leveraged his decades of experience and extensive network in the medical device field to gather a team of like-minded colleagues co-founders, Dan Davis, Pops current Security Officer and VP of R&D, and Curt Christensen, Pops VP of Operations with a mission to improve the lives of those with diabetes. Thus, in 2015, Pops Diabetes Care was launched by this team that understands what living with diabetes is like, and who are determined to make it easier for those with diabetes to control their blood sugar levels, therefore reducing their risk of expensive health complications.

Our vision is lowering the worlds A1c one person at a time, Stormo explains.

Their strategy involves addressing the reasons why many individuals do not adhere to regular testing. A Reality of Diabetes Care Survey reported by the Canadian-based Medical Education Network (Mednet) back in 2010, identified several of these reasons thus validating what those dealing with these challenges daily have been saying for years. These reasons, further characterized in subsequent studies, include forgetfulness, insufficient time for regular testing, not having all the things needed to test, unreliable meters, not wanting to carry around the equipment for the tests, pain and testing anxiety, inability to test discretely, lack of motivation, and even concerns regarding safe disposal of the used test strips and lances. A daunting list of deterrents that Stormo and his team were all too familiar with.

If we want people to manage their diabetes all the time and do it better, says Stormo, We have to give them a better experience. What we have done is reengineered that experience to make it easy for them to test their blood sugar less painfully, discretely, no assembly needed, anywhere, at any time, with non-invasive, non-judgmental virtual coaching.

Stormo and his team developed a portable test kit that can (doesnt have to) pop-on to the back of a smartphone to which it interfaces via wireless connection to a Pops virtual management care app.

I can now literally check my blood sugar anytime, anywhere while I am on the road for a run, something I could never do before, explains an enthusiastic Stormo, One time at a business competition, I was standing on stage and it was time to check my blood sugar levels. So right there in front of hundreds of people, I quickly pulled out my phone and discretely did a test. Simple. No fuss.

The Pops approach aligns with the current shift in individual behavior being observed across the healthcare landscape. Subject to a conventional system that does not always serve their best interests, patients are less passively resigned to receive services offered as is. Rather they are being more selective about their care and are actively pursuing alternatives that confer better outcomes.

This increasing demand for consumer-focused healthcare services is further bolstered by the recent acceleration in technological innovation. In an imperfect healthcare system, where many struggle to access appropriate care, it is not surprising that individuals are seeking solutions through advanced technologies that enhance the delivery of such care.

A 2017 report by consulting group, Deloitte Development LLC, indicates that over 70% of consumers in the US prioritize access thus are comfortable using virtual health platforms to manage their own care or coordinate with providers. According to Statista, 77% of US adults surveyed over a two-month period in 2018 were satisfied with their virtual care experience, confirming this trend.

People want to take healthcare into their own hands using technology, says Stormo, Previously, we were using technology to connect patients and doctors, sending information to the doctor then waiting for the doctor to respond with what to do, perhaps via a video console. Now people are managing their health directly using easy, convenient, smart technology. And living their lives. This is the next step virtual care people are empowered to self-manage their conditions.

Pops not only includes an integrated virtual care system they call Rebel, but also Mina, a 24/7, non-judgmental personal virtual coach. Rebel and Mina together provide non-invasive blood sugar-testing and monitoring along with basic analytics that inform guidance and support. In addition, everyone using the system is considered an owner controlling how and with whom, if anyone, their information is shared, whether its with friends, family and/or caregivers.

At Pops, we are enabling you to take care of yourself, to own your condition, to own your life, says Stormo, You have diabetes, but it does not define you. You are a person first and foremost.

Last year, Pops patented system received FDA clearance. Since then, they have established partnerships with healthcare plans and employers who have included Pops in their employee benefits offerings, promoting healthier employees, greater productivity at work, and an associated reduction in company healthcare costs. In the future, Stormo would like for everyone with diabetes to have access to Pops, regardless. For now, the system is not yet directly available to the consumer.

This purpose-driven company has been gaining attention across the country. Pops recently closed an oversubscribed Series A funding round of $6 million USD as a result of heightened investor interest. The round was led by 30Ventures, a healthcare and biotechnology venture capital firm based out of Madison, Wisconsin.

Also participating in this round was New York-based investment firm, Flying Point Industries and Revolutions Rise of the Rest Seed Fund, a Washington D.C.-based firm founded by AOL co-founder Steve Case that focuses on funding highly promising seed stage companies outside the startup hubs of Silicon Valley, New York City, and Boston.

In a recent press release, Stormo expressed his gratitude for the strong investor support, We are pleased that investors see this commercial growth as a sign that diabetes virtual care is making a difference for people with diabetes. The funds will be used to further the commercialization of Pops system.

Pops was also recently chosen to participate in the 2019 Winter Insurtech program run by globally renowned startup accelerator, Plug and Play.

Though grateful for the validation and support received this year, for Stormo, nothing comes close to the fullfilment he experienced that memorable day, when Pops received the first testimonial from the first person whose HbA1C levels were lowered by 1.5 points using the Pops system.

The first thing we see each day walking through the front doors is his framed photo the first person whose life we changed, says Stormo proudly, That is what our mission is all about!

For more information about Lonny Stormo and Pops, visit http://www.popsdiabetes.com.

REFERENCES:

https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death

http://www.mednet.ca/docs/pdf/HO10-005_E_with_WM.pdf

Josh Nelson, Bryan Sung, Sunil Venkataram, and Jennifer Moore, Transforming care delivery through virtual health, Deloitte, 2017.

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Pops on the go virtual care system empowers those with diabetes to Own Their Life - Silicon Prairie News

Diagnoses of diabetes, a condition where the body can't properly process glucose, havedoubled in recent years, andnearly 9% of the global populationnow has the condition.

But just because diabetes is common, it doesn't mean it isn't serious: diabetes can leave people blind, needing an amputation, and with a higher risk of heart disease. Treating diabetes accounts for1 in every 10 spent by the NHSin the UK, and $327 billion a year in the US. So could technology give diabetics a better way of managing their condition?

For a long time, to get their glucose reading, diabetics would have to prick their finger with a needle, squeeze out a drop of blood, and then use a handheld device to assess how much sugar was in it. It's a far from ideal process it only gives a snapshot of glucose control, not a long-term view. It has to be repeated several times a day, and it's tricky and painful to boot.

SEE: Exomedicine arrives: How labs in space could pave the way for healthcare breakthroughs on Earth (cover story PDF)

Technology aimed at insulin-using diabetics became mainstream a few years back with the arrival of continuous glucose monitoring (CGM) devices. These use small sensors that sit on a diabetic's body, monitoring their blood sugar levels constantly and relatively unobtrusively, through a small tube that samples the amount ofglucose in the interstitial fluid. This technology is transforming diabetes control for its users. By giving them a better view of what their blood glucose was doing, CGMs enabled insulin-dependent diabetics to take steps to keep readings in the right range.

As well as being more convenient, CGM offers a direct pay-off for diabetics' health too: those with better glucose control are less at risk of developing debilitating and life-threatening complications.

Now the companies that make these readers are looking to take advantage of broader technology trends to enable diabetics to better manage their condition.

The systems from Dexcom, one of the largest makers of CGM devices, are "a mix of medical technology with consumer technology", says its CTO Jake Leach. Whereas once CGMs would send a user's glucose reading to a separate handheld device, now makers are looking to exploit the potential of wearables and smartphones. Users can get their readings sent over Bluetooth Low Energy to hardware including iOS and Android phones and watches.

"The smartphone platform really opened up a lot of functionality that is not typical in medical devices," Leach explains.

One of the new features enabled by smartphone and mobile app use is remote monitoring. Through the Dexcom app, parents now keep an eye on their children's glucose levels even when they're not with them.

"The parent has the safety blanket of knowing how things are going. They can set up alerts and alarms that can communicate if there's an issue that has to be dealt with, so they don't have to worry as much," Leach says.

Remote management isn't only taking place between parents and children glucose readings are getting social, with the app allowing users to share their readings with a handful of friends and family via smartphone. Remote monitoring users who share their readings with others have lower average glucose readings, less time spent with low glucose, and more in the normal range, says Leach: "The folks that utilise that technology have better glucose control than those that don't and we kind of attributed it to the fact that they've got others helping them manage their diabetes."

As well as friends and family, CGM users can share their readings with their medical team. Glucose-monitoring apps can give physicians a long-term overview of how their patient's blood sugar has been doing, and why whether it's spiked or fallen due to a new medication or lifestyle change, for example. This can help guide how they treat the condition. "Diabetes is such an evolutionary thing and it develops over time and changes. You have to always be looking to change the way of managing it," Leach says.

SEE: The NHS wants more data about your health - and your smartphone could be the answer

For those who are keen to share even more, Dexcom's CGM app can feed data into other health apps through both Apple's HealthKit and Google Fit.

Dexcom already has a link with Google beyond its integration with Android: the CGM company inked a deal withVerily, the life-sciences arm of Google's parent company Alphabet, back in 2016 andamended it this year. The first hardware to sprout from the R&D partnership will be Dexcom's next generation of CGM, the G7. Unlike its predecessor, the G7 will be an all-in-one design carrying Verily electronics as well as Dexcom sensor tech onboard, and is expected to launch next year.

Verily and Dexcom have also teamed up on software, with Verily helping out with user engagement how to make sure that the app can keeping gaining functionality without making it too confusing for people that haven't used the app, or continuous glucose sensing, before.

And there is likely to be a lot of new users: the number of diabetics in the world is expected to rise from 171 million in 2000 to 366 million in 2030. Most of that growth, however, is likely to be in type 2 diabetics, who take other medications other than insulin and so don't use CGM.

However, CGM technology could ultimately be rolled out to people with type 2 diabetes, and those in the pre-diabetic range people whose blood sugar is higher than normal but not yet diabetic. The idea of getting people who aren't on insulin to use CGM is to show the impact of certain foods and behaviours on their glucose levels, and so help them to keep levels in the right range.

"Until you really have direct feedback, it can be hard to really understand why that's important," Leach says. "I think there can be a whole lot more around that coaching or the advice or the analytics that you put around the data to help you get more people with either pre-diabetes, or even with just general health and wellness. I think there's a lot of opportunity and there's quite a few pilots we're entering into any different areas to learn more about what works for those users."

For the traditional CGM user base people who control their diabetes with insulin injections the next few years are likely to bring another sea-change in technology with the advent of closed-loop or 'artificial pancreas' systems, single units that both monitor glucose and deliver insulin accordingly.

SEE: Apple's Research app: What does it want your health data for?

Other developments that could reshape diabetes management are on the horizon: technology that allows glucose readings to be taken non-invasively that is, hardware that can measure blood glucose without the need for, well, blood. Researchers are looking to create systems that can measure glucose through sweat, tears oreven just a user's vital signs.

"It is really challenging to measure glucose non-invasively," Leach says, "and no one has come up with a technology that is capable of measuring glucose to the kind of level of reliability and accuracy that's needed." Lots of companies are working on the field, but there's been no breakthrough yet Google's own experimental efforts to monitor glucose through contact lenses was kicked into the long grass.

That said, the future of CGM is going to be tightly tied to the development of consumer tech like smartwatches or other wearables. "There's a good possibility that you're going to have even tighter integration than we have today with those types of products," Leach says.

Read more:
Diabetes monitoring is having a smartwatch and smartphone revolution - ZDNet

Holidays can present special challenges for those who live with diabetes, particularly as people look for ways to either avoid temptation or make better choices while they navigate all the indulgences of the season.

Whether its dealing with busy schedules, extra stress, family gatherings or holiday eating, the holiday season brings many extra gatherings, social events and shopping, which leave us with even less time for healthy lifestyle habits such as exercise.

Towards the end of the year, many people really do celebrate a holiday season with multiple holidays occurring from October to January, many of which have a heavy focus on foods that are often high in sugar, sodium, fat and calories. Since research shows that weight gained during the holidays doesnt usually come off later in the year, its important to focus on weight maintenancethrough quality diets and physical activity during the holidays.

This not only helps our waistlines, but also helps us manage other health conditions such as diabetes and heart disease.

With that in mind, Jenny Lobb, a specialist with Ohio State Extension Service, and other food and nutrition experts offer the following tips to help you enjoy the holidays while managing your diabetes:

Manage your stress. Stress causes our bodies to stay in a constant state of fight or flight. In response, our bodies release hormones that affect the way our bodies release and use glucose. This can cause blood glucose (or blood sugar) levels to remain high and be more difficult to manage. Exercising, relaxing, meditating and yoga with deep breathing exercises are good.

Dont take a holiday break from physical activity. A regular exercise program improves blood sugars, decreases the risk of heart disease and helps you lose weight. Thirty minutes a day five times a week is good. Every day is better. You dont have to do it all at once. Break it up throughout the day.

Plan ahead. Stick to your healthy meal plan, plan menus in advance and take diabetes-friendly foods to gatherings.

When eating a holiday meal, try to consume only the amount of carbohydrates that youd normally consume, and dont skip meals or snacks earlier in the day to save carbs for later. This will make your blood glucose more difficult to control.

Keep desserts in check. Share a dessert, make desserts that youve modified to be healthy or politely decline dessert when you know youve reached your limit.

Watch your meal portion sizes.

Kathy Smith is a Texas A&M AgriLife extension agent.

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Diabetes and the holidays | Columns - Weatherford Democrat

Sam Pearson,1,* Noppadol Kietsiriroje,1,2,* Ramzi A Ajjan1

1Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, West Yorkshire LS2 9JT, UK; 2Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand

*These authors contributed equally to this work

Correspondence: Ramzi A AjjanLeeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, West Yorkshire LS2 9JT, UKTel +44 113 343 7475Email r.ajjan@leeds.ac.uk

Abstract: In recent years, newer drug classes for the treatment of type 2 diabetes mellitus have been released with significant effects on glucose lowering and weight reduction. One of the most promising classes in achieving these goals has been the glucagon-like peptide (GLP)-1 agonists. However, a difficulty with the use of these agents is the need for subcutaneous injections, which can be inconvenient to individuals living with type 2 diabetes. More recently, a GLP-1 agonist has been developed, semaglutide, that can be administered orally which has at least similar effects to the subcutaneous preparation from which this compound is derived. In this review article, we discuss the glycemic and cardiovascular effects of the GLP-1 agonists with special emphasis on oral semaglutide and the potential role of this therapy in individuals with type 2 diabetes.

Keywords: oral semaglutide, type 2 diabetes, treatment, glucagon-like peptide 1

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Oral Semaglutide In The Management Of Type 2 Diabetes: A Report On The | DMSO - Dove Medical Press

In the last nineteen years almost 50 thousand people have died from diabetes in the Yucatan Peninsula.

Since 2019, a little more than 24 thousand people have lost their lives as a result of diabetes, a disease that in 2018 showed a slight decline compared to last year, the National Institute of Statistics and Geography (Inegi) reported.

Although Yucatan, Campeche and Quintana Roo are among the 11 states with the lowest mortality numbers due to this disease, the figure remains alarming.

Diabetes is a chronic disease characterized by increased blood glucose levels and that without control, can lead to severe complications such as blindness or even death.

Symptoms include the excessive need to urinate; excessive thirst; excessive hunger; weight loss or gain without apparent cause, and sudden changes in vision.

From 2000 to 2008, 24,326 deaths were recorded in the Yucatan Peninsula, due to complications of this degenerative chronic disease, whose historical maximum was 3,290 deaths in 2016, while the minimum was 2,107 people died in 2011.

In 2018, a total of 3,014 died from this disease in the peninsula, 4.7 percent less than the previous year, when 3,161 died.

The federal Ministry of Health stressed the importance of carrying out dietary control, as it favors the reduction of blood glucose concentrations, indicating that diabetes is under control.

According to information from Inegi, in 2018, 101,257 deaths due to diabetes were registered in the country, with a decrease of five percent over the previous year, when the total was of 106,525.

The Yucatan Times Newsroom

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Since 2000, almost 50 thousand people have died of diabetes in the Yucatan Peninsula - The Yucatan Times

Type 2 diabetes occurs when the body doesn't produce enough insulin to function properly, or the body's cells don't react to insulin, which causes a rise in blood sugar levels.

Insulin is a hormone that made by the pancreas that allows the body to use sugar (glucose) from carbohydrates in the food that you eat for energy or to store glucose for future use but but it also plays a crucial role in stopping blood sugar levels from getting too high.

Consistently high blood sugar levels, if left unreated, can cause life-threatening risks, such as heart disease and stroke, so it is important that people with type 2 diabetes find alternative ways to control their blood sugar.

Diet is a key component of blood sugar management, and, as a general rule, cutting back on carbohydrates can help to lower blood sugar.

As Diabetes.co.uk explains: Carbohydrate is broken down into glucose relatively quickly and therefore has a more pronounced effect on blood sugar levels than either fat or protein.

A helpful way to distinguish between high-carb and low-carb food items is to follow the Glycemic Index (GI) - a relative ranking of carbohydrate in foods according to how they affect blood glucose levels.

Carbohydrates with a low GI value are more slowly digested, absorbed and metabolised and cause a lower and slower rise in blood glucose and,

therefore usually, insulin levels.

READ MORE:Type 2 diabetes symptoms: Noticing this sign on your skin could mean youre at risk

One food item with a particular low GI rating is chickpeas, and in addition, the legume is a good source of fibre and protein, which are both known for their role in blood sugar regulation.

Research into the effects of fibre shows that it slows carb absorption, which promotes a steady rise in blood sugar levels, rather than a spike.

Also, evidence shows that eating protein-rich foods may help maintain healthy blood sugar levels in individuals with type 2 diabetes.

In one study, 19 people who ate a meal that contained 200 grams of chickpeas had a 21 percent reduction in blood sugar levels, compared to when they ate a meal that contained whole-grain cereal or white bread.

Another 12-week study found that 45 individuals who ate 728 grams of chickpeas per week had a notable reduction in their fasting insulin levels, which is an important factor in blood sugar control

Furthermore, several studies have associated chickpea consumption with a reduced risk of several diseases, including diabetes and heart disease. These effects are often attributed to their blood-sugar-lowering effects.

In addition to focusing on the blood-sugar lowering benefits of eating specific food items, for optimal blood sugar management, it is important to adopt a healthy, a balanced diet.

According to the NHS, following the glycaemic index can help to stave off the risk of rising blood sugar levels, but other factors must also be taken into account.

It's also important to eat a healthy, balanced diet that is low in fat, sugar and salt, and high in fruit and vegetables, advised the health body.

If you've been advised to make changes to your diet, or you need advice, a diabetes dietitian can help you work out a diet plan, says the health site.

You can ask your GP about being referred to a dietitian.

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Type 2 diabetes: Include this 55p food in your diet to lower your blood sugar - Express

In healthy people, the hormone insulin is released by the pancreas, a gland present in the abdomen. This hormone regulates the levels of blood sugar. When levels of blood sugar are not appropriately controlled and become too high this is called as hyperglycemia and are diagnosed as diabetes mellitus. Unhealthy food habits lead to weight gain and obesity, insulin resistance which in turn causes both diabetes and predisposes to infertility.

When diabetes is left unattended it can affect your chances of getting pregnant and also the health of the pregnancy when pregnant. Risks of miscarriage, C-section, still births, foetal growth issues, and need for neonatal intensive care unit (NICU) are all higher in diabetic pregnancies. Babies of fathers with type 1 diabetes are at an increased risk of developing type 1 diabetes. It is heartening to know that diabetic fathers do not produce more malformed children than nondiabetics, only the general genetic remains as for anybody else. Diabetes in men too can majorly wreak havoc with their fertility and hamper a chance of having a baby.

Pre-diabetes and diabetes are more predominant in men than in women and the incidence is rising. This is becoming a huge concern for fertility doctors. Uncontrolled diabetes is associated with increased risk of sperm DNA damage resulting in higher risk of miscarriage. Even when there is good control of the condition this risk remains higher than in non-diabetics. Semen parameters like sperm motility tends to be poorer in diabetics and abnormal sperm forms tend to be higher. Diabetes is usually associated with obesity; this contributes to lower testosterone levels and loss of libido (sex drive), thus, reducing the frequency of intercourse and chances of conception. Diabetes is associated with nerve damage and also damage to blood vessels. This results in a host of sexual issues encompassing erectile dysfunction and ejaculation issues further hampering fertility. Diabetics due to the high sugar levels are more prone to infections in general. Infection, swelling and tenderness of the foreskin also known as balanitis makes it painful to have intercourse and affects fertility.

The good news is diabetes can be effectively managed to regulate blood sugar levels. This comprises of regularly checking your levels, consuming a healthy diet, engaging in steady physical activity, consistently staying in the healthy weight range, meditation, and relaxation techniques to reduce tension and anxiety, and quitting smoking and alcohol. Your health care provider may also suggest some medications if required. Well monitored blood sugar levels can lessen the risk of all the issues enumerated above.

Precautionary measures

Preferably, diabetes should be well under control for around three months before you start actively trying. This will reduce the diabetes-related risks of pregnancy. Meet your general practitioners (GP) or diabetes specialist as soon as you consider starting a family. When pregnancy does occur, it is best to consult a doctor as soon as you find out that you are pregnant, so that the required care can be taken.

A lot is talked about diabetes and obesity together causing problems with fertility. A healthy diet, regular exercising, and regular checks for diabetic control will vastly improve reproductive outcomes.

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Diabetes may cause infertility in men; here are some precautionary measures - Business Standard

By Ruby Prosser Scully

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Your gut microbes may determine how you respond to exercise. That is according to research showing how people with certain microbiomes have better metabolic outcomes after exercise. The discovery opens the door to diabetes treatments that target the microbes in our gut.

Type 2 diabetes is a growing problem internationally. While there is no cure, it can be prevented by early lifestyle interventions, says Aimin Xu at the University of Hong Kong.

Exercise is the most cost-effective strategy for diabetes prevention, he says. However, some people do not respond favourably to exercise.

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To understand why, Xu and his colleagues studied how exercise affected the microbiome and metabolism of 39 men with prediabetes, where blood sugar levels are higher than normal, but not high enough to qualify for a diagnosis of diabetes.

The participants, who had never taken medication for the condition, were randomly assigned either to a sedentary control group, or to a group that undertook a three-month, high-intensity, supervised exercise training course. They were told to maintain their usual diet.

While all participants in the exercise group had similar levels of weight and fat-mass reduction, only 70 per cent had significant improvements in glucose metabolism and insulin sensitivity, Xu found.

An analysis of their gut microbes revealed that the people who saw improvements in glucose metabolism and insulin sensitivity had significantly different microbiomes that were able to generate more molecules called short-chain fatty acids and break down more branched-chain amino acids. the microbiomes of non-responders were more likely to produce compounds that are harmful to metabolism.

Next, the researchers asked the study participants to provide faecal samples, and transplanted the microbes they contained into obese mice. Rodents receiving microbes from people who responded well to exercise went on to develop better insulin resistance and glucose regulation. The rodents receiving microbes from people who hadnt responded to exercise didnt see any boost to these processes.

[Our study] identifies maladaptation of gut microbiota as a culprit for those individuals who do not respond to exercise intervention, says Xu. This is one of the first interventional randomised control trial studies providing clear evidence of the role of gut microbiota on metabolic health.

The findings raise the possibility that targeting gut microbiota can maximise the benefit of exercise and could help doctors personalise treatments.

The study only included men. Gut microbiomes can differ depending on sex, so the team plans to undertake similar research into women and older people in the future.

Journal reference: Cell Metabolism, DOI: 10.1016/j.cmet.2019.11.001

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Gut microbes may predict whether exercising will prevent diabetes - New Scientist News

DEARBORN HEIGHTS, Mich. - "I don't want my father to die."

But that's exactly what Mariam Charara fears the most as her dad, Median El-Moustrah is facing. Being placed in an ICE detention center since Nov. 12, El-Moustrah has a slew of medical issues. Living with liver damage, hepatitis B, diabetes, and hearing loss, El-Moustrah is now at the mercy of an immigration system that Charara says she's displeased with.

"As a United States citizen I'm ashamed of this system, I am so ashamed of this system," she said.

While his potential exit is imminent, El-Moustrah's issues actually take root more than a decade ago.

"They had asked him back in 2007 when he was in front of the judge about a marriage date and because he forgot his anniversary, they deemed it to be enough evidence to say it was marriage fraud," said Charara.

Median El-Moustrah is very ill. He has liver damage, hepatitis B, diabetes and hearing loss. And since Nov. 12, he's been in a detention center run by ICE. Facing the prospect of deportation, his daughter is working to exhaust every opportunity to keep her dad from being sent back to Lebanon.

El-Moustrah's marriage to a U.S. citizen in the 1990's was a brief one, lasting about a year. However, he was able to obtain a green card.

Years after his marriage ended, problems started to arise within the legal system after he applied to extend his green card in 2007 - and couldn't remember his anniversary date.

His first wife later stated in an affidavit that they were indeed married for love, but since that court date, he's been at risk for deportation. All of this despite having no criminal record and living in the United Statesfor 30 years.

"He's a businessman. He employees eight other people, he pays taxes every single year," said Charara.

When Charara thinks about what might happen to her dad, she thinks of Jimmy Aldaoud - the metro Detroit man who was deported to Iraq earlier this year. Having never visited the country or spoken the language and facing his own degree of health problems, he died weeks after arriving back in the country when he couldn't get the insulin he needed to survive.

RELATED:Detroit man deported to Iraq in Trump's ICE sweep, diesfrom lack of insulin

To remedy the issue, Charara has submitted letters to Immigrations and Customs Enforcement from doctors located both in the U.S. and Lebanon, stating that her father - who is awaiting a liver transplant - will not get the medical care he needs if he deported.

Her letter ends by stating El-Moustrah could "face a certain death from his illness."

Charara said her family was informed the day before Thanksgiving that their father could be deported as early as next week.

"I'm just trying to make sure I turn every stone to know I can put my head in that pillow and say I did everything I can," she said.

FOX 2 reached out to ICE for a comment, and they said they could not respond until Monday.

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'Facing a certain death;' Man with liver damage, hepatitis B and diabetes facing deportation - FOX 2 Detroit

Diabetes Symptoms: Early signs of diabetes are visible on skin

Diabetes symptoms: Diabetes is affecting many today. Early diagnosis and treatment for diabetes can help in controlling the diseases on time. As uncontrolled blood sugar levels are associated with many severe complications one need to take necessary precautions to control the disease on time. During the early stage you may experience symptoms like frequent urination, increases hunger, blurry vision, fatigue, increases thirst, tingling in hands and feet, yeast infections and slow healing of wounds. Symptoms of diabetes are visible on skin as well. Uncontrolled blood sugar levels also affect the skin of the patient. Here are some common visible signs of diabetes on skin.

During the initial stage a diabetes patient may experience patches on the skin. Patches of dark skin can form on the neck or armpits. This patch can be soft. In some cases one may experience pale skin.

Diabetes: Uncontrolled blood sugar levels can affect skin in various waysPhoto Credit: iStock

Uncontrolled diabetes mainly contributes to skin issues. Dr. Manjunath Malige explains the relations between diabetes and skin issues and also explains different skin conditions that can happen due to diabetes. All these skin complications of diabetes can be prevented with good control of diabetes.

Diabetes, particularly poorly controlled diabetes can affect the skin in many ways. Diabetic Dermopathy is a term used to describe the small, brownish spots on the skin particularly in front of the legs. Patient usually does not develop any symptoms due to these skin spots and these occur in about 55% of patients with diabetes. It is more common in older patients with long-standing diabetes. These changes in skin happen due to decrease in the blood circulation to the skin due to diabetes.

Also read:Diabetes: Turmeric Can Help You Control Blood Sugar Levels; Here's Is The Right Method To Use It

Although, this condition in itself does not require any specific treatment, this may well indicate the presence of far more serious complications of diabetes like retinopathy (eye damage), nephropathy (kidney damage) and neuropathy (nerve damage). Cosmetic camouflage maybe used to disguise the appearance of the skin spots if required. The finding of such skin spots in patients not previously known to have diabetes should prompt investigations to check for the presence of diabetes. Good diabetes control in patients with diabetic dermopathy can reduce the risk of other complications of diabetes.

Diabetes Symptoms: Dark patches are one of the earliest sign of diabetesPhoto Credit: iStock

Also read:Diabetics, Here's How Uncontrolled Blood Sugar Levels Can Affect Your Skin

1. Patients with diabetes are also at risk of developing Diabetic Bullae also known as bullosis diabeticorum, where blisters develop in the skin. These if present are distinct markers of diabetes.

2. Many patients with type 1 diabetes develop stiffness of the skin known as diabetic cheiroarthropathy. This results in restricted mobility of joints of the hands with stiff, waxy, thickened and yellow skin.

3. Necrobiosis lipoidica is a condition where yellow, waxy spots appear in the skin in front of the legs.

4. Diabetic patients, particularly if overweight or obese, can develop darkening and thickening of skin folds, thought to be due to insulin resistance. This condition is called acanthosis nigricans.

5. Apart from these, diabetic patients are at risk of developing recurrent fungal infections particularly around the private parts.

Also read:Diabetes Diet: What Is Glycemic Index? Top Foods With Low- Glycemic Index That Every Diabetic Must Know

(Dr. Manjunath Malige is the Chief and Senior Endocrinologist and Diabetologist at Aster RV hospital, Bangalore)

Disclaimer: This content including advice provides generic information only. It is in no way a substitute for qualified medical opinion. Always consult a specialist or your own doctor for more information. NDTV does not claim responsibility for this information.

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Diabetes Symptoms: Dark Patches On Your Skin Can Be A Sign Of Diabetes; Here's Everything You Need To Know About Diabetes And Skin - NDTV News

The global rise in people suffering from type 2 diabetes is expected to drive the global non-insulin therapies for diabetes market. The global non-insulin therapies for diabetes market is estimated to reach a market value of US$ 64,590.6 million in 2019 and it is expected to reach US$ 105,461.5 million by 2027, growing at an estimated CAGR of 6.3% over the forecast period.

Globally, diabetes is considered to be the most common disease and is ranked as top ten fatal disease in the U.S. Non-insulin therapies are frequently used in type 2 diabetes, accounting more than 90.0% of the diabetes cases. The rising economic burden of diabetes is substantially very high and is expected to surge in the coming future. According to statistics published by the American Diabetes Association (ADA), in March 2018, the cost to diagnose diabetes have increased to US$ 327 billion in 2017. Hence, non-insulin therapies for diabetes hold promising future in the coming years.

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Garlic

Garlic is a source of allicin which lowers blood pressure, cholesterol and makes arteries more elastic, plus ajoene which helps to lower blood glucose levels," said Dr Brewer.

She added: "Aged garlic also contains potent antioxidants such as sallylcysteine. 2.7g/0.1oz fresh cloves per day (two to three cloves) can lower LDL-cholesterol enough to cut your risk of a heart attack or stroke by 25 percent.

"Ajoene can lower glucose levels by 25 percent. Aged garlic inhibits formation of glycated proteins. Recent research suggests that garlic oil improves glucose tolerance and can decrease protein loss through the kidneys.

Ginger

Ginger contains gingerol, zingerone and essential oils. Gingerol reduces blood clotting, boosts circulation and lowers blood pressure," said Dr Brewer.

"Research suggests ginger increases insulin secretion and increases insulin-sensitive glucose uptake in fat (adipose) cells. Preliminary research suggests it may also reduce diabetes-related kidney damage.

Grapefruit

Grapefruit contain antioxidants, with red grapefruit having a higher flavonoid and anthocyanin content.

"Grapefruit interacts with several prescription drugs, including statins check medication insert sheets. Both blond and red grapefruit lower LDL-cholesterol (7 percent for blond, 15 percent for red), while red grapefruit lowers triglycerides by 17 percent (5 percent for blond)," said Dr Brewer.

Grapes

Grapes, especially lack grapes, are rich sources of antioxidant anthocyanadins such as resveratrol.

"Compounds found in red grapes can significantly increase levels of protective, antioxidant glutathione in pancreatic cells and increase insulin production in type 2 diabetes," said Dr Brewer.

Jerusalem artichokes

Jerusalem artichokes contain the enzyme, inulase, and a complex sugar, inulin, made up of units of fructose giving it a low glycemic index. Inulin and inulase may help to stabilize glucose levels, especially when combined with higher GI foods," said Dr Brewer.

Olive oil

Olive oil is a good source of monounsaturated fats and antioxidants: vitamin E carotenoids and polyphenols," said Dr Brewer.

She added: "A diet rich in olive oil has been shown to reduce blood pressure, and the risk of coronary heart disease by 25 percent.

"Following an olive-oil rich Mediterranean-style diet is predicted to prevent over 90 percent of type 2 diabetes, 80 percent of coronary heart disease and 70 percent of stroke when combined with regular physical activity and not smoking.

Oranges

Oranges especially the red blood oranges have high levels of antioxidant vitamin C, anthocyanidins and flavones.

"Cyanidin-3-glucoside and delphinidin-3-glucoside found in red oranges were recently shown to promote insulin secretion to improve glucose tolerance," said Dr Brewer.

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Type 2 diabetes: Best foods to include in your diet to lower blood sugar - Express

The month of November is dedicated to national diabetes awareness, with the 14th of November being dedicated as World Diabetes Day. The intention is to raise awareness about a disease that afflicts 30.3 million people nationwide, nearly 10% of the United States population.

However, even with the staggering numbers and an entire month being dedicated to the awareness and prevention of such a disease, diabetes specialists and patients alike do not believe the populace gives it the attention it needs.

Tricia Dutra, a medical assistant at the University of Maryland Charles Regional Health Center who works with diabetes patients, said her office sees upwards of 30 diabetic patients daily between three doctors, highlighting the fact that a large amount of the local population struggles with diabetes.

Even with the local and national figures, Dutra said she has not seen any increased awareness due to Diabetes Awareness Month.

Everybody knows about Breast Cancer Awareness Month, which is extremely important, and Heart Disease Awareness Month, but nobody ever thinks about diabetes, Dutra said. What a monster disease it is; people just dont realize how bad it is.

Of course, diabetics themselves and their immediate family members are well aware of the severity of the disease. Diabetes prompts not only the patients, but their families, to make adjustments in their lives to compensate for their predicament.

Heidi Jackson, a patient at Charles Regional Health Center, was diagnosed with type 2 diabetes at age 40 and her daughter, Heather Oliver, has been her caretaker since.

Jackson said she was not aware of the severity of the disease upon diagnosis which in turn led to her needing additional care.

A lot of things happen to you when you dont take care of yourself. It affects all of your organs, Jackson said. Theres a lot of people out there that are walking around with diabetes and they dont know they have it. So the public needs to be more aware of this.

Oliver agrees that the public needs to be more educated on the adverse affects of diabetes, plus preventative actions that citizens can take.

Even with having an immediate family member affected by diabetes, Oliver said the message of the national diabetes month is unclear other than the obvious fact: take care of yourself.

I think it should get as much awareness as breast cancer does, Oliver said. People need to go have their A1C checked and have that part as their yearly physical. I also think they probably could use a bit more funding because insulin is really, really expensive and there are a lot of people out there who have a hard time affording it.

Lack of knowledge and insulin prices have contributed to 23.8% of diabetes cases going undiagnosed, along with it being the seventh leading cause of death in the United States.

This is not to say diabetes is a death sentence, as plenty of diabetics lead functioning lives after diagnosis by making the proper adjustments in their daily routines.

Ray Bazil, another patient at Charles Regional, experienced a tremendous amount of impact on his daily life when he was diagnosed with type 2 diabetes in 2004, but said now things are a bit more regulated.

Bazil said he has completely restructured his diet, eating six small meals a day, in addition to staying away from sugary drinks and processed foods.

You have to monitor and be more careful about what you eat and how you eat, Bazil said. Be aware of it. Dont be fearful of it. Know that you can manage it, and know that you can take care of yourself.

Bazil mentioned that he was not aware of the message a national diabetes month presents, but credits the medical staff for helping him make the adjustments to live a functioning life with diabetes.

A reason people are not fully aware of the adverse affects of diabetes could be not having any direct or indirect contact with the disease. Through no fault of their own, people become ignorant of how important a structured diet and active lifestyle is to long term health.

Diabetes can manifest itself anywhere with anyone, it is a non-discriminatory disease that even experts on it are at risk of developing.

Such is the case with Natasha Adams, a medical assistant at Charles Regional. Adams has been working with diabetes patients for 17 years and was diagnosed with type 2 diabetes this past February.

Adams used her diagnosis as a motivating factor to prompt changes not only in her life, but in the lives of her patients who may believe the disease is uncontrollable.

You have to be vested in you. Its not just based on the treatment, but you as the patient have to be willing to participate and do whats needed to make the changes, Adams said. I tell patients from my standpoint, look I get it, so I try to be a positive role model to the patients to let them know I am doing it, and you can do it as well.

Adams stated that the lack of awareness, sedentary lifestyles and prices of medication all contribute to the diabetes crisis, having an impact on both a local and national scale.

Many people cant afford medication, so now people are at the point where they debate, Do I buy my food, do I pay my bills, [or] do I get my medication? Adams said. The cost becomes extreme. The government contributing more would definitely help to bring down the numbers.

If you have it, embrace it. If you embrace it, then you try to control it, Adams said. You try to do more, you try to let other people know its not a death sentence, you can actually live with it, you can live a long life with it, too.

Dutra explained that exercise and a controlled diet can prevent the development of diabetes to begin with.

It doesnt have to be strict, you dont have to follow Atkins or Keto or anything like that, but just use basic common sense, Dutra said. Moderation is the key. Realize you have limitations.

Patients and medical staff alike agree that awareness of a preventable disease must be increased, along with the promotion of a structured, controlled diet and active lifestyle.

Twitter: @RyanVollandIndy

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NEW YORK, Nov. 12, 2019 /PRNewswire/ -- The North America diabetes care devices market is expected to reach US$ 15,300.0 Mn in 2027 from US$ 8,936.5 Mn in 2018. The market is estimated to grow with a CAGR of 6.3% from 2019-2027.

Read the full report: https://www.reportlinker.com/p05794734/?utm_source=PRN

The growth of the diabetes care devices market is primarily attributed to the growing geriatric population and rapid technological advancements in diabetes care devices.However, high cost of diabetes care devices and risks associated with the insulin delivery devices are likely to pose a negative impact on the market growth.

On the other hand, development of cost efficient pen needles is likely to have a positive impact on the growth of the North America diabetes care devices market in the coming years.The advancement in the field of the healthcare industry is driving to the players for more research and developments for insulin delivery devices.There are many methods to deliver insulin into the body such as needles, insulin pens and insulin pumps.

Insulin pumps are small computerized diabetes management devises, connected with cannula under the skin that is used to deliver a slow continuous level of insulin.The program can be controlled by the individual depends on the more or less requirement.

The increasing advancements and technology in glucose monitoring devices have result into smaller required blood volumes with improved accuracy.The ability to transfer data between the blood glucose (BG) meter and insulin delivery devices has been also improved.

The increasing advancements in blood glucose (BG) monitoring technology have resulted in improved accuracy, smaller required blood volumes, and the ability to transfer data between the BG meter and insulin delivery devices. For instance, in September 2016, the FDA announced their first automatically automatic glucose monitoring device, Medtronic's MiniMed 670G which is a hybrid closed looped system that provide suitable insulin doses in patient of age 14 years and above with diabetes type 1. Pen needles and syringes are the most commonly used device for injecting insulin to the diabetic patients. In addition, to reduce the injection site repetition for drug administration, montmd Inc. in April 2017 introduced a new a variant of SiteSmart colored pen needles to keep the injection site tissue healthy and promote better insulin adoption. Thus, the technological advancements coupled with increasing influx of new products into the market is expected to propel the growth of global pen needles market over the forecast years.

In 2018, the glucose monitoring devices segment held a largest market share of 54.2% of the diabetes care devices market, by product. The glucose monitoring devices is expected to dominate its market share in 2027 owing to the rise in the prevalence of the diabetes and presence of the several market players that offers technically advanced products. The testing strips segment among the glucose monitoring devices is anticipated to witness the fastest growth rate of 7.2% during the forecast period, 2019 to 2027 owing to the enormous usages in the glucose monitoring devices.

Homecare held a largest market share of 59.9% of the diabetes care devices market, by end user in 2018. This segment is also expected to dominate the market in 2027 owing to the rise in the demand for the glucose monitoring devices and insulin delivery devices. Increasing diabetic population, the ease of use, availability, and accessibility of insulin delivery devices has also increased the adoption of self-administration among patients is anticipated to grow at a steady rate during the forecast period. Also the homecare segment is also expected to grow at the fastest growth rate of 6.6% during the forecast period, 2019 to 2027.

Some of the major primary and secondary sources for diabetes care devices included in the report are, Associao de Diabetes Juvenil (ADJ), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), International Diabetes Federation(IDF) National Institute for Health and Care Excellence (NICE) and others.

Read the full report: https://www.reportlinker.com/p05794734/?utm_source=PRN

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The North America diabetes care devices market is expected to reach US$ 15,300.0 Mn in 2027 from US$ 8,936.5 Mn in 2018 - PRNewswire