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When a person has type 2 diabetes, its important for them to be diagnosed as early as possible because untreated symptoms can lead to dangerous and sometimes irreversible consequences. These complications include damage to the eyes, nerves and kidneys. Some common diabetes symptoms are fatigue, lethargy, confusion, nausea and increases urination. There is an unusual symptom of the condition which lies in a persons skin - if your skin feels this way it may mean youre at risk of developing the condition.

American Diabetes Association said: Diabetes can affect every part of the body, including the skin.

In fact, such problems are sometimes the first sight that a person has diabetes. Luckily, most skin conditions can be prevented or easily treated if caught early.

Some of these problems are skin conditions anyone can have, but people with diabetes get more easily.

These include bacterial infections, fungal infections and itching. Other skin problems happen mostly or only to people with diabetes.

These include diabetic dermopathy, necrobiosis lipoidica diabeticorum, diabetic blisters and eruptive xanthomatosis.

DONT MISS

Dr David Bradley, assistant professor of endocrinology, diabetes and metabolism at The Ohio State University Wexner Medical Centre in Columbus said: High blood sugar increases the risk of skin infections caused by bacteria and yeast.

"Also, poor circulation and nerve damage caused by diabetes can cause itching, too.

"When blood sugar levels are too high for too long, several changes take place in the body that affect skin health.

"Blood sugar leaves the body through the urine and so when there is too much blood sugar, a person will urinate more and this can result in dehydration and skin.

High blood sugar levels can also lead to inflammation.

Over time, this can dull or over stimulate the immune response.

Nerve and blood vessel damage can also reduce circulation. Poor blood flow can alter the skins structure, especially its collagen.

Without healthy collagen networks, the skin can become stiff and in some cases, brittle as collagen is necessary for proper wound healing.

Read this article:
Type 2 diabetes symptoms: Skin that looks and feels this way could be a warning sign - Express

Feb 18, 2020 7:00 AM

More than 30 million people in the United States have diabetes. About seven million of those people dont know they have it. Symptoms of untreated diabetes include:

Believe it or not, erectile dysfunction (ED) can also be a symptom of diabetes. In fact, half of men diagnosed with diabetes experience ED within ten years of their diagnosis.

We see quite a few men for erectile dysfunction that end up being diagnosed with diabetes after their visit with us. Most people dont think about the penis being an indicator of other, underlying health issues, but it really is a good barometer.

In order to get an erection, men need healthy blood vessels and nerves. High blood sugar levels, a symptom of diabetes, can damage blood vessels as well as the nerves that control sexual stimulation. Because diabetes can cause the inner lining of blood vessels to function abnormally, it can affect blood flow to the penis, which is how you get and maintain an erection.

Managing your diabetes can stop the progression of ED, but sometimes symptoms dont improve because of nerve damage. There are many treatment options for ED if you dont see an improvement after getting your diabetes under control.

Oral medications typically work about 50 percent of the time for men with diabetes. Penile pumps are also good options, if medications dont work. Other men may choose injection therapy, which is a treatment where you inject the penis with a small needle when you want an erection.

Penile implants are another ED treatment. Implants last 1215 years on average.

All of these treatment options have pros and cons. Men should consider what works best for their lifestyles when chatting with their provider about the best choice for them.

Erectile dysfunction is frustrating and stressful for men and their partners. Its not something people should just live with, Dr. Hotaling said. If youre struggling with ED, talk to your health care provider. Sometimes its an unrelated problem. Other times, its linked to something more serious, like diabetes or heart disease. Regardless, its worth getting treated.

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Diabetes and ED: Symptoms, Treatment - University of Utah Health Care

Positive results have been announced from part 2 of the phase 2 Simplici-T1 trial assessing TTP399 as an oral adjunctive therapy to insulin in adults with type 1 diabetes (T1D).

TTP399 is a novel, once-daily, liver-selective glucokinase activator. Simplici-T1, a multi-center, randomized, 12-week trial, investigated the efficacy and safety of 800 mg of TTP399 compared with placebo in 85 patients with T1D on optimized insulin therapy.

The trial successfully achieved its primary objective, which was analyzed using 2 statistical approaches to evaluating the effect of TTP399. The primary statistical analysis evaluated the effect on long-term blood sugar (HbA1c) regardless of treatment adherence or notable change in insulin administration.

Under the primary statistical analysis, the trial achieved its primary objective by demonstrating statistically significant improvements in HbA1c for TTP399 compared with placebo at week 12.

TTP399 was well tolerated with similar incidences of treatment-emergent adverse events (AEs) overall and by system organ class in both treatment groups. The study had no report of diabetic ketoacidosis in either treatment group. There was no incidence of severe hypoglycemia in the treated group and 1 incident in the placebo group.

Patients taking TTP399 experienced fewer symptomatic hypoglycemic episodes: 2 subjects taking TTP399 reported at least 1 AE compared with 8 subjects taking placebo.

In order to rule out that the reduction of HbA1c was driven by the administration of excess insulin (3 or more units per day), a second statistical analysis was performed. Based on this analysis, patients treated with TTP399 achieved a statistically-significant, placebo-subtracted reduction in HbA1c. Patients taking placebo experienced a 0.11% increase in HbA1c from a mean study baseline HbA1c of 7.6% following a multi-week insulin optimization period prior to the administration of study treatment.

Daily time in range was improved by approximately 2 hours in patients treated with TTP399 relative to placebo (p=0.03). TTP399 treatment reduced the total daily meantime bolus insulin dose by 11% relative to baseline (p=0.02), whereas the placebo-treated group experienced a 3% decrease relative to baseline.

TTP399 selectively activates glucokinase (GK), a key regulator of glucose metabolism in the liver. This activation has been shown to increase glucose utilization, which in turn lowers blood glucose. Simplici-T1 is the first study to test activation of GK in patients with T1D, evaluating daily oral TTP399 as an adjunct to insulin therapy.

Reference

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Oral Adjunctive Therapy Yields Positive Results for Adults with Type 1 Diabetes - Pharmacy Times

Submitted Published 5:02 a.m. ET Feb. 17, 2020

Afterschool children promote the Y's upcoming participation in the major countywide fundraiser, Give Where You Live Collier.(Photo: Photo provided)

As fundraisers go, this one is a biggie for the YMCA of South Collier (Marco Y).

In a nutshell, the Y collects money for a Countywide drive called Give Where You Live Collier, and then gets it back (and then some) by way of matching funds.

The major fundraiser serves 40 pre-selected non-profits (of which the Marco Y is one) that will benefit from the 24-hour fundraiser taking place noon Feb. 19 to 11:59 a.m. Feb. 20.

Aquatics, sports and specialty camps director Morgan Joseph instills the importance of physical activities to some of the Y's early learners (pre-school).(Photo: Photo provided)

The participating organizations do their own fundraising, and money raised is swelled with matching funds from the Community Foundation of Collier County and Richard M. Schultze Family Foundation.

This year, Marco's Y is focusing its campaign on diabetes prevention and supporting its specialty summer camps for diabetic children.

On-site nurse Monica Ramos delights an early learning (pre-school) student by letting her hear heartbeats.(Photo: Photo provided)

Described as a "growing epidemic," diabetes cases (including types 1 and 11) have risen more than 30 percent since 2000, with many more going undiagnosed until a medical crisis occurs.

The Y's development director, Charlie Vickaryous, notes that 2020 will mark the third year that the organization has partnered with Help a Diabetic Child and Core Health Partners to provide the camp.

Depending on money raised, a second camp is envisaged. In addition, the Y will incorporate an extensive diabetes prevention and intervention program into all summer camp sessions, which serve more than 600 children throughout southern Collier County.

The YMCA of South Collier is a major human service organization providing support for all ages and all income levels throughout Southern Collier County, including Marco, Goodland, East Naples, Everglades City and surrounding areas. More than 10,000 people 2,000 of whom are children benefit each year.

For more information, contact Vickaryous at commdev@marcoy.org - or call 394-9622.

Read or Share this story: https://www.marconews.com/story/news/2020/02/17/funds-help-y-focus-diabetes/4771791002/

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Funds will help Y to focus on diabetes - Marco News

Diabetes is one of the largest, most expensive problems facing America's veterans, and the US government is staking its hopes for a solution on an unconventional treatment: the popular keto diet.

The Department of Veterans' Affairs (VA) has launched a partnership with a digital therapeutics startup Virta Health to treat diabetic veterans using the low-carb, high-fat keto diet, at no cost to the vets or the VA.

The partnership, first announced in May 2019, has enrolled 400 veterans into Virta's program, which includes personalized nutrition plans and online access to health coaches and physicians.

So far, the results have been promising, according to the company's data. A pilot program with the VA found that half of the participating veterans achieved blood sugar levels below the threshold for diabetes after three months on Virta's program. And the treatment successfully reduced medications, including insulin, by 53% across the entire group.

But some experts have raised concerns that there may be unforeseen health consequences following this kind of treatment, and that the VA's buy-in will lend legitimacy to what is still an experimental treatment.

Prior to working with the VA, Virta had been studying keto as a treatment for diabetes for over two years.

Diabetes is an inability to balance blood sugar.Reducing carbs manages the problem at the source by preventing blood sugar from rising in the first place, according to Dr. Mark Cucuzzella, a professor at West Virginia University School of Medicine, a US Air Force Reservist, and a marathon runner who has published several studies on keto and diabetes.

Hollis Johnson/INSIDER "The most impactful thing on your blood glucose is the amount of carbs in your diet. The low-carb diet is effective because it lowers the insulin load," Cucuzzella, whois not affiliated with Virta, told Insider in an interview. "Insulin is the master switch."

Medications like insulin can mitigate diabetes symptoms by managing blood sugar levels. But keto can help patients reduce medications, said Dr. Sarah Hallberg, medical director for Virta.

Eating carbohydrates causes blood sugar to rise, but eating fats does not. It means diabetic patients can get their daily calories without needing to use insulin to balance out spiking blood sugar levels.

"Standard treatment puts people on a one-way street of progression for diabetes, with temporary pharmaceutical treatment that will have to be added on to," Hallberg told Insider. "We're able to give people another lane going the other way by bringing blood sugar into non-diabetic range while reducing and eliminating medication."

That doesn't mean keto can cure diabetes.

Virta refers to its treatment as a "reversal" of diabetes. In layman's terms, this means the disease is in remission. The treatment only works as long as the low-carb diet is maintained. As soon as carbs are re-introduced, the same problems with blood sugar and insulin emerge.

A keto diet is any eating plan that pushes the body into a state of ketosis when it begins producing substances called ketones, explained Dr. Ethan Weiss, a cardiologist and founder of a ketone-detecting device. (Weiss previously served as a medical advisor for Virta.)

"Keto" typically refers to eating plans in which a majority of daily calories come from fat, along with some protein and minimal carbs.People with diabetes could cut their carb intake to as low as 30 grams a day and still be healthy.

But the key to medical keto is going beyond counting macronutrients. Instead, it's important to focus onwhole-food sources of fats, cutting carbs without completely eliminating nutrient-rich foods like veggies.

Vietnam war veterans among other guests listen to U.S. President Barack Obama at the Memorial Day observance at Arlington National Cemetery in Washington, U.S., May 30, 2016. REUTERS/Yuri Gripas

It's not clear what long-term health effects the keto diet might have.

The Physicians Committee for Responsible Medicine, a group of medical experts who advocate a plant-based diet, sent a letter to VA officials asking them to reconsider the partnership, and keto treatment, based on evidence that a high-fat, low-carb diet could potentially increase risks of diabetes, particularly diets high in saturated fat.

Skeptics have also noted that most of the data showing keto can treat diabetes is based on studies led and funded by Virta itself. There is barely any hard data on keto's health effects beyond two years on the diet.

Hallberg acknowledged the lack of long-term evidence, but said the same problem has plagued nearly every other type of therapeutic diet (with the exception of the Mediterranean diet).

"There's needs to be a hard outcome, long-term trial looking at a variety of eating patterns, no question," she said.

But in the meantime, diabetes continues to be diagnosed in record numbers, particularly among military veterans.

"Do we have 10-20 years to wait for that?We're in the midst of an unprecedented diabetes and obesity epidemic," she said. "We have to do something now."

Read more:

Nutrition experts react to the keto diet's new ranking as one of the worst diets of 2020

There's a Mediterranean version of the keto diet that restricts red meat and trades butter for olive oil

The keto diet makes mice better at fighting the flu another clue about how the high-fat, low-carb plan changes the body

View original post here:
Keto diet is being used by government to treat veterans' diabetes - Insider - INSIDER

According to the Center for Disease Control and Prevention, more than 100 million U.S. adults are now living with diabetes or pre-diabetes.

At the Mississippi Gulf Coast YMCA in Ocean Springs, they are trying to lower that number with their Diabetes Prevention Program.

This program provides a supportive environment where participants work together in a small group to learn about healthier eating and increasing their physical activity in order to reduce their risk for developing diabetes. Community Impact Director Jodi Ryder said, You know, we have such a high incidence of type two diabetes and type two diabetes is preventable. The biggest cause of type two diabetes seems to be linked to lifestyle, not making the right food choices, not getting enough activity, and carrying excess weight.

If you are interested in participating in this class contact the YMCA at 228-875-5050 for more information.

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Diabetes Prevention Program at the Gulf Coast YMCA - WXXV News 25

Women who survive domestic abuse are more likely to suffer from heart disease, diabetes, and all-cause mortality, which refers to death from any cause, a study has revealed. Researchers found that women in the U.K. who lived through domestic abuse were 31 percent more likely to develop heart disease, and had a 51 percent higher chance of having type 2 diabetes. The participants also had a 44 percent higher risk of dying from any cause. The authors of the study examined data from the medical records of tens of thousands of women in the U.K. who visited doctors between Jan. 1, 1995 and Dec. 1, 2017. They matched the data of 18,547 women who had experienced domestic abuse by age and lifestyle with women who had not suffered from domestic violence.

Domestic abuse was defined as any incident or patterns of incidents of controlling, coercive, threatening behavior, violence or abuse between those aged 16 or over who are, or have been, intimate partners or family members regardless of gender or sexuality. Domestic abuse victims were more likely to drink, at 10.1 percent compared to 3.5 percent in the other group.

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Women Who Survive Domestic Abuse at Higher Risk of Heart Disease, Diabetes: Study - The Daily Beast

Women who survive domestic abuse are more likely to develop heart disease, diabetes, and die of any cause, a study has revealed.

Researchers found women in the U.K. who experienced domestic abuse were 31 percent more likely to develop heart disease, and had a 51 percent higher chance of having type 2 diabetes. The participants were also 44 percent higher risk of what is known as all-cause mortality.

Lead author of the study Dr. Joht Singh Chandan, public health doctor at the University of Warwick and University of Birmingham, told Newsweek "all-cause mortality" refers to death from any cause.

He explained: "So in these records we can't discern the exact cause, we just know the patient had died."

The authors of the paper published in the Journal of the American Heart Association looked at data from the medical records of tens of thousands of women in the U.K. who visited doctors between January 1, 1995 and December 1, 2017.

A total of 18,547 women had experienced domestic abuse, and their data was matched by age and lifestyle with four women (72,231 in total) who hadn't experienced domestic violence, to compare their health. The participants were aged 37 on average.

Domestic abuse was defined as "any incident or patterns of incidents of controlling, coercive, threatening behavior, violence or abuse between those aged 16 or over who are, or have been, intimate partners or family members regardless of gender or sexuality."

Some 27.1 percent of women in the U.K. on average suffer domestic abuse at some point in their lives. In the U.S., one in four women and one in nine men experience some form of intimate partner violence or stalking, according to the National Coalition Against Domestic Violence.

The participants were more likely to come from deprived areas compared with the national U.K. average, and 44.7 percent smoked. Women who experienced domestic abuse were more likely to drink than the other group, at 10.1 percent versus. 3.5 percent.

But domestic abuse survivors were still more likely to have conditions like heart disease and diabetes even when researchers accounted for these variables, suggesting their lifestyles were not the only explanation for higher risk, the team said. More research is needed to understand how to help these women and pinpoint what might explain the link, the authors said.

However, Chandan said the study was limited because cases might not be accurately recorded.

"It is clear that domestic abuse is heavily under-recorded in GP [family doctor] records and so there may be individuals in the control group who have experienced abuse but are miscoded as not experiencing abuse. However, in reality this may mean we are under-estimating the findings," he explained.

Chandan said he wanted to conduct the study because he is both a medical doctor and a volunteer detective for West Midlands Police force in the U.K. "I see lots of survivors of abuse with poor health and wanted to understand why as well as how we can best support them," he said.

Read more:
Women Who Survive Domestic Abuse More Likely to Develop Heart Disease, Diabetes, Die of Any Cause - Newsweek

Is Type 1 diabetes dramatically more common than is widely understood? Thats the contention of Dr. David Leslie, Professor of Diabetes and Immunology at London Universitys Blizard Institute.

In the United States, about 30 million people are said to have diabetes. Of those, about 1 million are diagnosed with Type 1, and the other 29 million are diagnosed with (or suspected of having) Type 2. But is that ratio accurate? Or does it reflect a misunderstanding of the nature of Type 1 diabetes?

Dr. Leslie thinks the real numbers will definitely be different:

The number of people with Type 1 is probably much higher than weve accounted for. That 29 million something like 2 million of them may have undiagnosed Type 1.

The misdiagnosis of Type 1 diabetes is already a known problem. Its easy for doctors to confuse Type 1 with Type 2, especially among adult patients and those displaying some of the indicators of the latter condition, such as obesity. A recent study from the University of Exeter last year showed that 38% of patients with Type 1 diabetes occurring after age 30 were initially treated as Type 2 diabetes, and, even more strikingly, that half of those misdiagnosed were still diagnosed as Type 2 diabetes 13 years later.

According to Dr. Leslie, even these numbers may underreport the problem: In our research, of those adults who presented with [Type 1] diabetes, the ratio of those that did not require insulin, compared to those who did, was about 3:1.

Dr. Leslie is a recognized leader in the world of diabetes research, having served as principal investigator on several major European trials. We were first alerted to his work when a fascinating paper that he authored came across the ASweetLife desk: C-peptide persistence in type 1 diabetes: not drowning, but waving?

The paper, published in the journal BMC Medicine, discusses surprising amount of variance in C-peptide persistence in people with Type 1 diabetes. While it was once thought that everyone with T1D rapidly declined towards zero insulin production, what we now know is that C-peptide persistence varies widely across a spectrum. Most people with T1D retain at least some ability to produce insulin, even after many years, and many retain so much that they havent even been identified as having T1D.

And so the old image of T1D as a disease of the young is gradually getting turned on its head. Various studies have shown that among T1D patients requiring insulin immediately, just as many were diagnosed in adulthood as in childhood. Thats without counting the unknown millions that have a mild or slow-developing form of the disease and have yet to be identified.

Dr. Leslie told me, I see patients every week who are diagnosed in adulthood and are told, Thats it, Type 2, end of story. They dont get the antibodies test. Every week I see people like that. When Dr. Leslie tests them, he will often learn that they do have the autoantibodies that define Type 1 diabetes.

Dr. Leslie explained that it only became evident as late as the 1970s that adults were developing variants of Type 1 diabetes that did not require insulin. In the years since, researchers have begun to identify a bewildering diversity of specific types of Type 1 diabetes, each with their own unique criteria, such as LADA, MODY and SPIDDM. But even while awareness of adult-onset diabetes and these associated conditions has grown, many experts still tend to view Type 1 diabetes through the prism of our old understanding of it as a juvenile or insulin-dependent disease. It was only within the last decade, for example, that the Juvenile Diabetes Research Foundation officially changed its name to JDRF.

The old stereotypes are still strong. When I was diagnosed (as an adult) I had more than a few people express surprise that it was even possible for an adult to develop T1D. One too-confident acquaintance told me that I was in error, and that I had Type 2. Unfortunately, many on the front lines of diabetes, such as the primary care providers and family doctors that are often the first to see a patient with the symptoms of hyperglycemia, still cling to these old assumptions.

Dr. Leslies contention reminds us that proper diabetes management requires self-examination and self-advocacy. Diabetes is not a disease that allows one to simply accept a doctors prescription uncritically. Patients themselves have the primary responsibility of monitoring their own blood sugar levels and evaluating the success of their medicine, diet, lifestyle and exercise choices.

Sometimes, unfortunately, the need for self-advocacy extends even to question of the diagnosis itself.

Read more from the original source:
Is Type 1 Diabetes Much More Common than We Think? - A Sweet Life

Grace Lieberman, Cronkite News

Originally Published: February 18, 2020 11:54 a.m.

PHOENIX Cooking equipment at the ready, Mallory Smith stands before a table loaded with fresh greens, nuts and fruit.

Has anyone used the apple slicer before? she asks the dozen people gathered this weekday morning at Native Health. Might take a little bit of practice.

Over the next hour, Smith chopped, mixed and scooped as she demonstrated how to make a chicken Waldorf salad as part of a new class to encourage diabetes-friendly cooking to help diabetics manage their blood sugar.

A lot of people in the Native American community and in the Phoenix community, they get diagnosed with diabetes but arent necessarily educated on it, Smith said. Having this class helps them find out what diabetes is, what kind of foods they can eat with diabetes, what can help them for their overall health.

The 20-week course, which is free and open to anyone, is held morning and evening every Thursday through June 4. Each week, Smith demonstrates a new recipe, and participants go home with free groceries to replicate the dishes at home.

Food for Thought is part of Native Healths diabetes management program for the Native American community. Michelle Hill, a certified diabetes educator at Native Health, said the goal is to show patients that eating properly can be easy, accessible and economical.

More than 30 million Americans have diabetes, according to the American Diabetes Association. That includes 695,000 Arizonans or 12.5 percent of the adult population.

Both nationally and in Arizona, Native Americans have the highest rates of the disease, followed by blacks and Hispanics. More than 19 percent of adult Native Americans in the state have been diagnosed, the Arizona Department of Health Services reports.

Type 1 diabetes is a condition in which the body does not produce any insulin, which helps regulate blood sugar. In the more common type 2 diabetes, the body produces insulin but does not use it properly. Some people only need to maintain a healthy diet and exercise regimen to manage the disease, while others might need insulin injections or other medicines.

In order to properly regulate their blood sugar, diabetics are cautioned against eating foods high in processed sugar, such as white bread, sugary cereals and flavored yogurt and drinks. Hill told participants they should not be afraid to eat natural sugar found in whole fruits.

Glorene Barton learned about Food for Thought from her health care providers during a recent appointment at Native Health.

I was asking about snacks, because Im a diabetic and I forgot to bring a snack with me. So she told me about this class that might be interesting for me, Barton said. I learned a few different things about eating and grams and carbs and things of that nature. It was interesting.

Another participant, Marla Wilson, said her son motivates her to keep up with a healthy diet. She thought this program was a great opportunity to learn how.

I have a son whos very health-conscious. So Im sure hell like it, too, because we were just talking about eating more salads and the health benefit, Wilson said.

Participants learned they can test their bodies reaction to new foods by trying them over a few days, then checking their blood sugar levels two hours later each time.

Where it was time to get cooking, with Smith guided the group through the process.

The ingredient that surprised people the most was nonfat yogurt, which was used along with lemon juice to dress the salad. Smith said yogurt is an excellent substitute for less healthful ingredients, such as sour cream.

At the end, participants were able to take home both dry goods and fresh produce funded by the Mobilize AZ project from Blue Cross Blue Shield of Arizona.

Being diabetic is a very expensive way of being, and so this is a plus, Wilson said. We get what we need to make our dinner tonight.

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Health provider offers cooking classes to address high rates of Native diabetes - Navajo-Hopi Observer

SEATTLE , Feb. 18, 2020 /CNW/ --LumiThera Inc., a commercial stage medical device company delivering photobiomodulation (PBM) treatment for ocular disorders and diseases, today announced it has initiated further studies with the University of Wisconsin-Milwaukee to establish the use of their Photobiomodulation platform in Diabetic Retinopathy (DR).

"Recent research in our labs in both preclinical and clinical areas have indicated potential in treating diabetic edema with PBM," stated Janis Eells , Ph.D., Professor, University of Wisconsin-Milwaukee . "Our work shows that early PBM benefits in reducing the detrimental effects of high glucose on retinal cells and early human data is now starting to show benefits in the clinical setting."

DR is the leading cause of blindness in the world. The International Diabetes Foundation 2019 Fact Sheet estimated that globally 463 million people have diabetes now, and future estimates suggest that this number will increase to 578 million by the year 2030.

"We have been working with Dr. Eells and the University of Wisconsin-Milwaukee on our dry AMD research and the work in DR and Diabetic Macular Edema (DME) is a logical extension of our PBM platform," stated Clark E. Tedford , Ph.D., President and CEO of LumiThera, Inc. "The results from Dr. Eell's lab point to the multiple cellular benefits of treating the disease early and PBM would be an alternative approach for treatment of early disease."

LumiThera was granted a CE mark to commercialize the Valeda System in European Union for the treatment of ocular diseases including dry AMD.The company previously announced that the National Institutes of Health and division of the National Eye Institute have provided a $2.5M grant to support the LIGHTSITE II multi-center clinical trial to lead to U.S. approval for dry AMD.The Company is enrolling two multi-center trials, one in European Union and one in the US for dry AMD. The entry into DME provides a second major ocular disease platform for the Valeda system.

"We are excited to be involved in the development of Valeda for both non-neovascular (dry) AMD and DME. We are currently enrolling patients in the LIGHTSITE III study and believe that PBM could be an even bigger platform for DME," remarked Quan Dong Nguyen , M.D., M.Sc. and Diana V. Do, M.D., Professors of Ophthalmology at the Byers Eye Institute, Stanford University . "DME is the leading cause of functional vision loss among working adults worldwide. Treatments with intravitreal injections of pharmacologic agents are effective but can be costly and invasive. PBM could provide a significant improvement to the current practices with its non-invasive approach."

"I am continually impressed with the scientific foundation that LumiThera is building for PBM with collaborations in both preclinical and clinical research," stated David Boyer , M.D., Retina-Vitreous Associates Medical Group. "The benefits for PBM on multiple critical cellular pathways involved in the disease etiology in preclinical work is now being evaluated in the clinical setting and could change the way we address chronic disease that leads to blindness."

Visit the Company's website at http://www.lumithera.com.

About LumiThera Inc.LumiThera is a commercial-stage medical device company focused on treating people affected by ocular disorders and diseases including dry AMD, a leading cause of blindness in adults over 65 and DR, the leading cause of blindness in the world. The company is a leader in the use of PBM for treatment of acute and chronic ocular diseases and disorders. The company is developing the office-based Valeda Light Delivery System to be used by eye care specialists for medical treatment.

The Valeda Light Delivery System has been granted authorization to use the CE Mark by an EU Notified Body as required for commercial use in the European Economic Area only. Valeda is not approved for use by the Food & Drug Administration (FDA) in the USA .

2020 LumiThera, Inc., All rights reserved.

View original content:http://www.prnewswire.com/news-releases/lumithera-to-expand-research-into-diabetic-retinopathy-for-valeda-light-delivery-system-301006356.html

SOURCE LumiThera Inc.

View original content: http://www.newswire.ca/en/releases/archive/February2020/18/c7986.html

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LumiThera to Expand Research into Diabetic Retinopathy for Valeda Light Delivery System - Yahoo Finance

Research study on Global Type-1 Diabetes Treatment Market Examination of Market Segmentation Including Product Type, Application, And Regions

Global Type-1 Diabetes Treatment Market comprises the estimation of the market including industry analysis, size, share, growth, trends, outlook, and forecasts 2019-2024. Global Type-1 Diabetes Treatment the industry is just the resource that players need to strengthen their overall growth and establish a strong position in their business. The report analyzes historical data, facts, current growth factors, and market threats with a competitive analysis of major market players. The report covers consumption, revenue, sales, production, trends, opportunities, geographic expansion, competition, segmentation, growth drivers, and challenges. The report presents the scope of different segments and applications that can potentially influence the global market in the projection period from 2019 to 2024.

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The well-established key players in the market are:Astellas Pharma, Abbott Laboratories, Merck, Novo Nordisk, Sanofi, Eli Lilly, Novartis, AstraZeneca, Pfizer Inc., Boehringer Ingelheim GmbH, Mannkind Corporation, Macrogenics, Inc., Braun Melsungen AG

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The report deals with the key factors driving the commercial landscape of the global Type-1 Diabetes Treatment market over the analysis period. Market share and growth rates accounted for by every application over the estimation timeline are encompassed in the report. It provides analysis on the industry chain scenario, key market players, market volume, upstream raw material details, production cost, and marketing channels. The report covers analysis on consumption volume, region-wise import/export analysis and forecast market from 2019-2024.

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Moreover, the report gives revenue estimates of the global Type-1 Diabetes Treatment market based on top industry players, their product type, applications, and regions. It has mentioned the production volume and consumption volume during the forecast period. Then, the sale worth is for varied sorts, applications, and regions also are enclosed.In addition, sort wise and application wise consumption figures also are provided.

Customization of the Report:This report can be customized to meet the clients requirements. Please connect with our sales team ([emailprotected]), who will ensure that you get a report that suits your needs. You can also get in touch with our executives on +1-201-465-4211 to share your research requirements.

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Global Type-1 Diabetes Treatment Market | Industry Size, Growth Opportunities, Competitive Analysis and Forecast to 2024 - Nyse Nasdaq Live

Two Co Down students have become the stars of a new series of videos - which have gone viral - aimed at making it okay to have diabetes. Best friends Ellen Watson (19) and Beth McDaniel (20), from Banbridge, are smashing the stigma of Type 1 diabetes - a lifelong condition that causes a person's blood sugar level to become too high and for which daily injections of insulin are needed - thanks to their hugely popular TikTok videos.

alling themselves the Diabetic Duo, the young women have amassed hundreds of thousands of followers in just a few months through their refreshing, light-hearted posts about living with Type 1 diabetes.

TikTok is a popular video-sharing social network service used to create short film clips which can last from three to 15 seconds.

After posting their first video last October, Ellen and Beth knew they had hit a nerve when it was viewed overnight by 500,000 people and eventually scored more than 700,000 hits.

They were then inundated with messages from young people around the globe congratulating them on raising awareness about living with diabetes.

Ellen and Beth - who are both studying at Ulster University - live together, work together at the weekends, are cheerleaders and love to shop.

We use our free style libras to check our blood sugar levels using our phones they are a gift from god #fyp #diabeticduo #belfast #trending

Ellen has lived with diabetes since the age of six and was shocked when Beth was diagnosed just last September.

The two friends support each other, counting calories to ensure their diets are healthy and keeping tabs on monitoring blood sugar levels.

Ellen knows what it's like to grow up under the shadow of diabetes, having tried to hide it for years from her school friends, which is why she is thrilled that the videos are having such a big impact.

"I grew up with diabetes and have had it for as long as I can remember," she says. "When I was really young I just did what my mum told me and then as I got older I had to learn to keep an eye on my sugar levels myself.

"I became really conscious of it in high school when I was 13. I didn't want people to know I had it and I would have tried to inject myself under the table in the canteen at lunchtime without anyone knowing.

"When I got a bit older I did grow to accept it a bit more and see the positive side. I have great community support with my doctor and nurses who are all lovely and show you how to live with it.

"My mum Sharon is a nurse and she always kept me right. New technology has really helped make life with diabetes a lot easier."

Ellen was on hand to support her best friend Beth when she was diagnosed in September of last year - incredibly, within just a week of her 12-year-old sister also being diagnosed.

Injecting in strange places#diabeticduo #foryoupage #belfast #holylands #t1dcat #hypo #trending

"We have no family history of diabetes but last August my little sister Grace took sick and was diagnosed with diabetes which was a big shock for our family," Beth says.

"Seven days later, on September 4 - a day I will never forget - I, too, was diagnosed. My parents were still in shock over Grace's diagnosis and just couldn't believe it when I was told I had it, too.

"I knew it was diabetes as I had all the symptoms. I was really sluggish and didn't want to get out of bed and was very thirsty. I also had blurred vision and I felt very irritable.

"I believed in my head that I had it and my dad took to me to hospital where it was diagnosed. My mum was devastated.

"At first I found it really hard to come to terms with and I cried every day for the first two weeks.

"I never liked needles and I would have sat staring at my belly for 10 minutes before plucking up the courage to inject myself.

"The finger-pricking to check blood sugar levels was also really sore.

"Ellen and I share accommodation at university and we just sit at the dinner table some nights and laugh because we always shared everything and we can't believe we now both have diabetes.

"We inject at the same time and we both count our calories to make sure we are eating property.

"Ellen has been such a huge support and I really wouldn't have coped so well over the last few months without her."

A great support to each other, the girls have been inseparable since they first met four years ago while working in the same shoe shop in their home town of Banbridge.

They hit it off immediately and not only did they have a lot of interests in common, but they both looked alike.

"We just clicked and everyone thinks we are twins because we look so much like each other," Beth laughs.

"We even picked similar courses at the same university. Ellen is studying marketing at the Ulster University and I'm studying communications, advertising and marketing.

"We also live together in the same student accommodation and that has brought us even closer together."

Type 1 diabetes is different to Type 2 - the latter is usually associated with lifestyle, in particular being overweight, and presents later in adult life.

Ellen and Beth say that a general lack of understanding in the difference between the two is a huge reason why they believe there is a stigma surrounding living with diabetes.

People with Type 1 diabetes are insulin-dependent as their pancreas produces little or no insulin - the hormone which regulates blood sugar.

People with Type 2 diabetes can manage the disease with a healthy lifestyle and diet. However, most also have to take medication.

The girls have been breaking down barriers by recording videos showing them openly injecting insulin and proudly wearing their sugar monitoring discs on their arms during nights out.

A new device called the FreeStyle Libre is a glucose-monitoring disc which can be worn on the arm and, linked to a phone app, monitors blood sugars automatically. While you may still need to do some finger-prick tests, this nonetheless provides an enormous benefit.

Indeed, Ellen says it has revolutionised how she is able to manage her diabetes and even her mum has access to the same app which displays a graph of her blood sugar levels throughout the day.

Wearing the arm sensor, which is around the size of a two-pence piece, on their videos has endeared them to other young people who felt the need to hide their diabetes.

When you and your bestie have a hypo at the same time #diabeticduo #fyp #belfast #foryoupage #hypo #trending #besties

The students aim to keep their videos funny while promoting the message that it is okay to have diabetes.

They have been astonished by the reaction.

"I was constantly asked if I was overweight as people automatically assume that is why I have diabetes and with the videos we've been able to shatter that myth," Ellen says.

"People are quite shocked that we are young and eat well and look after ourselves and still have diabetes.

"We already did some fun videos as 'the iconic duo' as we are always together and always doing the same thing and even wear the same outfits.

"We thought we should make one for the craic for TikTok and add diabetes as an element - overnight it went viral with half a million views and in the end more than 700,000 people watched it and we just couldn't believe it. People saw the scanner on our arms and were shocked that we would wear it so openly on a night out.

"For us it is a way to create a bit of fun out of a lifelong illness.

"We've had messages from all over the world, from Scotland, Australia and America, and we just seem to be getting more and more every day.

"Many are from children and young people our age who are asking us questions and, while we know we are not in a position to give medical advice, we are happy to support people who contact us.

"I feel that it really would have helped me if I had something similar to look out for when I was younger as there was no one I knew my age who had diabetes and who I could relate to."

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Fun times: The Diabetic Duo are often mistaken for twins

Kevin Scott

Beth agrees and adds: "It is all about changing the stigma as a lot of people don't understand the difference between Type 1 and Type 2 diabetes. I love how we are inspiring people and it's great to be able to post positive things online.

"I think it is really important to bring positivity to it with a bit of fun at the heart of it. People can be really negative about it and we are glad to be able to bring it out in the open and show we are not uncomfortable with it.

"We've done a range of funny videos including one where we pretended to be our nurses checking our blood cells and the nurses and doctors in our local practice said they loved it.

"We also did one on injecting insulin in strange places and we videoed ourselves injecting in front of a police car, while doing our cheerleading and eating a sausage roll in Greggs and that was viewed by half a million people.

The response has been incredible and we are constantly having people come up to us in shops and the street recognising us as the Diabetic Duo. We feel like local celebrities!"

You can watch Ellen and Beth on the TikTok app via @diabeticduo. Beth also writes a beauty blog you can find at bethymcdaniel.wordpress.com

The number of people in Northern Ireland living with Type 1 and Type 2 diabetes is now 100,000, according to figures published by http://www.diabetes.org.uk. This number includes the estimated 12,000 who have not yet been diagnosed with Type 2 diabetes.

Prevalence of diabetes in NI is now over 5.7% and approximately 90% of diabetes cases are Type 2, the NI Audit Office reports.

Type 1 diabetes

Type 1 has no relation to diet or lifestyle and it is not clear what causes it.

The cells of the pancreas which make insulin are attacked which means that insulin production is suppressed.

Because insulin regulates blood sugar, without this control in place glucose levels in the blood build up.

Symptoms: before diagnosis, your body tries to remove glucose through the kidneys, which means you go to the toilet a lot.

The patient can be very thirsty, feel tired more than usual, lose weight unexpectedly and have blurred vision. These symptoms can present within days or weeks and the patient should seek medical attention as soon as possible.

Managing Type 1 diabetes: insulin must be injected or delivered to the body via a pump. Blood sugar levels should be checked several times a day.

Type 2 diabetes

Six out of 10 people have no symptoms when they're diagnosed with Type 2 diabetes. However, symptoms are similar to those for Type 1.

Managing Type 2 diabetes: most people need medicine to help keep blood sugar levels as normal as possible. Sticking to a healthy diet and keeping active will help you manage blood sugar.

Around 2.5 hours of activity a week is recommended - this could include fast walking, climbing stairs and doing more strenuous housework or gardening.

Losing weight if you're overweight is important as it will help your body to lower your blood sugar level, and can improve blood pressure and cholesterol.

Regular monitoring and check-ups are important as complications of Type 2 diabetes can include heart disease and stroke, nerve damage, foot problems, vision loss and kidney problems.

Sources: http://www.diabetes.org.uk and http://www.nhs.uk

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Northern Ireland 'Diabetic Duo' who have gone viral with online videos that smash stigma of life with the illness - Belfast Telegraph

Type 2 diabetes is a condition which results in the body losing control of the amount of glucose in the blood, causing blood glucose levels becoming too high. If blood glucose isnt controlled properly and stays too high, it can lead to a number of problems, including kidney failure, nerve damage, heart disease and stroke.

Eating a regular poor diet can increase a persons risk of developing type 2 diabetes, so making diet changes is recommended.

Carbohydrates you eat and drink are broken down into glucose, and the type and amount you consume can make a difference to a persons blood glucose levels and diabetes management.

So when it comes to one of the famous carbohydrates, bread, what type is considered best or what advice should you follow?

Diabetes UK explains: There are two types of carbohydrate: starchy carbohydrates and sugars.

READ MORE:How to live longer: People with this condition 50 percent more likely to die early

Bread falls into the starchy carbohydrate category. All carbohydrates affect blood glucose levels.

Carbohydrate requirements vary between individuals and depend on age, gender, weight and physical activity.

The Reference Intake (RI) of carbohydrate is 230g for women and 300g for men.

These figures are just a guide and are based on the requirements of an average woman and man. Depending on your nutritional goals, you may require less.

DON'T MISS

Most supermarkets and local markets contain different types of bread, the type diabetes charity offers advice for next time youre choosing a loaf.

Per slice, the following types of bread contain:

These could be served with lean chicken, ham, turkey or beef plus chopped tomatoes, grated carrot and cucumber, or reduce-fat cheddar with grated carrot and sultanas.

Sourdough, rye and soda bread may be served with turkey, chicken or Swiss cheese with shredded lettuce, tomatoes and reduced-fat mayo.

These types of bread contain:

Brioche can be served warm with jam or pure fruit spread. It contains:

Garlic and ciabatta bread contain:

Garlic and ciabatta breada are often available to buy already sliced. so you can control your portion sizes.

Naan and chapatti contain:

Diabetes UK says you should try to avoid adding extra butter, margarine or ghee.

The NHS states theres nothing you cannot eat if you have type 2 diabetes, but certain foods should be limited.

It advises: You should eat a wide range of foods including fruit, vegetables and some starchy foods like pasta, keep sugar, fat and salt to a minimum, and eat breakfast, lunch and dinner every day do not skip meals.

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Type 2 diabetes: Best bread to choose if you want to lower blood sugar - Express

CLEVELAND, Feb. 18, 2020 (GLOBE NEWSWIRE) -- DiasomePharmaceuticals, Inc., a company developing hepatocyte directed vesicle (HDV) technology that can be added to any commercially available insulin to optimize treatment for people living with diabetes, today announced positive results from its Phase 2 OPTI-1 study of injectable hepatocyte directed vesicle (HDV) added to mealtime insulin in people with type 1 diabetes (T1D).

One of the trials investigators, Bruce Bode, M.D., a diabetes specialist with Atlanta Diabetes Associates and clinical associate professor in the Department of Medicine at Emory University, added, The OPTI-1 study may be the first clinical trial to demonstrate the impact of the combined effects of liver targeted insulin and physiologically driven changes in the ratio of mealtime to long-acting insulin regimens. These results provide additional evidence that targeting insulin to the liver induces a more physiological response. When added to insulin, HDV may allow patients to optimize the amount of short-acting and long-acting insulin they need to reduce the incidence of hypoglycemia while still achieving positive long-term health outcomes.

This open-label, multicenter study was designed to evaluate the effect of HDV added to rapid-acting mealtime insulin on A1C, hypoglycemia, and bolus and basal insulin dosing in adult T1D patients with baseline A1C levels between 6.5% and 8.5%. Patients underwent a three-month run-in period on standard-of-care therapy followed by three months of treatment with HDV added to mealtime insulin in conjunction with optimized basal insulin doses. A total of 61 T1D patients were enrolled at eight United States trial sites. After patients were treated with standard-of-care Lispro or Degludec during the run-in period, they were randomized into one of two groups: HDV-Lispro (HDV-L) in conjunction with a 10% reduction in Degludec or HDV-L in conjunction with a 40% reduction in Degludec.

The completion of this clinical trial marks an important milestone for the continued development of HDV, said Robert Geho, chief executive officer of Diasome. Results from this study, which we plan to present at upcoming conferences, continue to support the hypothesis that improved mealtime insulin delivery to the liver should have an important and positive effect on overall glycemic control. We are excited about these results and look forward to sharing additional details soon.

About Hepatocyte Directed Vesicle (HDV) TechnologyHDVs are the most advanced technology designed to restore normal physiology and potentially offer protection against hypoglycemia for patients with diabetes. Only 20-50 nanometers in size, these two-layered microscopic discs are designed to bring insulin to receptors highly expressed by liver cells. Liquid HDV can be mixed with any commercially available insulin prior to administration and is compatible with any insulin delivery system.

About Type 1 Diabetes (T1D)T1D is a chronic, auto-immune disease characterized by the inability of the pancreas to produce insulin, which leads to elevated blood sugar levels. Diabetes costs represent a large burden to both patients and the healthcare system. More than 1.25 million Americans are living with T1D and there is no cure.

About OPTI-1The 24-week, open-label, multiple dose trial is designed to assess the safety, tolerability and efficacy of hepatocyte directed vesicle (HDV) technology when added to rapid-acting mealtime insulin. All patients received insulin Lispro and Degludec during a 12-week run-in period. After completing the run-in period, patients were randomized to a treatment group of either HDV added to Lispro (HDV-L) while continuing Degludec at a dose reduced by 40% or HDV-L while continuing Degludec at a dose reduced by 10% for 12 weeks of treatment.

About Diasome Pharmaceuticals, Inc.Diasomes hepatocyte directed vesicle (HDV) technology is the only pharmaceutical insulin additive being developed to prevent hypoglycemia by restoring normal liver physiology in patients with diabetes. HDV technology is a Phase 3-ready asset designed to improve the safety and efficacy of all insulins. For more information, visit http://www.diasome.com or follow us on Twitter.

Investor Contact:Jeremy FefferLifeSci Advisors, LLCjeremy@lifesciadvisors.com+1.212-915-2568

Media Contact:Cherilyn Cecchini, M.D.LifeSci Communicationsccecchini@lifescicomms.com+1.646.876.5196

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Diasome Announces Positive Results from Phase 2 OPTI-1 Study of Hepatocyte Directed Vesicle Technology in Type 1 Diabetes - GlobeNewswire

Tandem Diabetes Care, Inc. (TNDM) is priced at $86.03 after the most recent trading session. At the very opening of the session, the stock price was $86.34 and reached a high price of $87.19, prior to closing the session it reached the value of $83.02. The stock touched a low price of $84.51.

Tandem Diabetes Care, Inc. had a pretty favorable run when it comes to the market performance. The 1-year high price for the companys stock is recorded $83.91 on 02/14/20, with the lowest value was $45.61 for the same time period, recorded on 02/26/19.

Price records that include history of low and high prices in the period of 52 weeks can tell a lot about the stocks existing status and the future performance. Presently, Tandem Diabetes Care, Inc. shares are logging 2.53% during the 52-week period from high price, and 88.62% higher than the lowest price point for the same timeframe. The stocks price range for the 52-week period managed to maintain the performance between $45.61 and $83.91.

The companys shares, operating in the sector of healthcare managed to top a trading volume set approximately around 1.83 million for the day, which was evidently higher, when compared to the average daily volumes of the shares.

When it comes to the year-to-date metrics, the Tandem Diabetes Care, Inc. (TNDM) recorded performance in the market was 44.32%, having the revenues showcasing 37.34% on a quarterly basis in comparison with the same period year before. At the time of this writing, the total market value of the company is set at 4.91B, as it employees total of 653 workers.

According to the data provided on Barchart.com, the moving average of the company in the 100-day period was set at 64.59, with a change in the price was noted +21.14. In a similar fashion, Tandem Diabetes Care, Inc. posted a movement of +32.58% for the period of last 100 days, recording 1,484,676 in trading volumes.

Total Debt to Equity Ratio (D/E) can also provide valuable insight into the companys financial health and market status. The debt to equity ratio can be calculated by dividing the present total liabilities of a company by shareholders equity. Debt to Equity thus makes a valuable metrics that describes the debt, company is using in order to support assets, correlating with the value of shareholders equity. The total Debt to Equity ratio for TNDM is recording 0.00 at the time of this writing. In addition, long term Debt to Equity ratio is set at 0.00.

Raw Stochastic average of Tandem Diabetes Care, Inc. in the period of last 50 days is set at 96.09%. The result represents improvement in oppose to Raw Stochastic average for the period of the last 20 days, recording 94.45%. In the last 20 days, the companys Stochastic %K was 93.36% and its Stochastic %D was recorded 92.18%.

Now, considering the stocks previous presentation, multiple moving trends are noted. Year-to-date Price performance of the companys stock appears to be pessimistic, given the fact the metric is recording 44.32%. Additionally, trading for the stock in the period of the last six months notably improved by 50.64%, alongside a boost of 74.57% for the period of the last 12 months. The shares increased approximately by 10.47% in the 7-day charts and went down by 15.07% in the period of the last 30 days. Common stock shares were driven by 37.34% during last recorded quarter.

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Analysts Mean recommendation for Tandem Diabetes Care, Inc. (TNDM) was 2.00: Is this the key time? - The InvestChronicle

Whether baked, mashed, fried, boiled, or steamed, potatoes are one of the most popular foods in the human diet.

Theyre rich in potassium and B vitamins, and the skin is a great source of fiber.

However, if you have diabetes, you may have heard that you should limit or avoid potatoes.

In fact, there are many misconceptions about what people with diabetes should and shouldnt eat. Many people assume that because potatoes are high in carbs, theyre off-limits if you have diabetes.

The truth is, people with diabetes can eat potatoes in many forms, but its important to understand the effect they have on blood sugar levels and the portion size thats appropriate.

This article tells you everything you need to know about potatoes and diabetes.

Like any other carb-containing food, potatoes increase blood sugar levels.

When you eat them, your body breaks down the carbs into simple sugars that move into your bloodstream. This is whats often called a spike in blood sugar levels (1).

The hormone insulin is then released into your blood to help transport the sugars into your cells so that they can be used for energy (1).

In people with diabetes, this process is not as effective. Instead of sugar moving out of the blood and into your cells, it remains in circulation, keeping blood sugar levels higher for longer.

Therefore, eating high-carb foods and/or large portions can be detrimental to people with diabetes.

In fact, poorly managed diabetes is linked to heart failure, stroke, kidney disease, nerve damage, amputation, and vision loss (2, 3, 4, 5, 6).

Therefore, its usually recommended that people with diabetes limit their digestible carb intake. This can range from a very low carb intake of 2050 grams per day to a moderate restriction of 100150 grams per day (7, 8, 9).

The exact amount varies depending on your dietary preferences and medical goals (9, 10).

Potatoes spike blood sugar levels as carbs are broken down into sugars and move into your bloodstream. In people with diabetes, the sugar isnt cleared properly, leading to higher blood sugar levels and potential health complications.

Potatoes are a high carb food. However, the carb content can vary depending on the cooking method.

Here is the carb count of 1/2 cup (7580 grams) of potatoes prepared in different ways (11):

Keep in mind that an average small potato (weighing 170 grams) contains about 30 grams of carbs and a large potato (weighing 369 grams) approximately 65 grams. Thus, you may eat more than double the number of carbs listed above in a single meal (12).

In comparison, a single piece of white bread contains about 14 grams of carbs, 1 small apple (weighing 149 grams) 20.6 grams, 1 cup (weighing 158 grams) of cooked rice 28 grams, and a 12-ounce (350-ml) can of cola 38.5 grams (13, 14, 15, 16).

The carb content of potatoes varies from 11.8 grams in 1/2 cup (75 grams) of diced raw potato to 36.5 grams in a similar serving size of french fries. However, the actual serving size of this popular root vegetable is often much larger than this.

A low GI diet can be an effective way for people with diabetes to manage blood sugar levels (17, 18, 19).

The glycemic index (GI) is a measure of how much a food raises blood sugar compared with a control, such as 3.5 ounces (100 grams) of white bread (1, 11).

Foods that have a GI greater than 70 are considered high GI, which means they raise blood sugar more quickly. On the other hand, foods with a GI of less than 55 are classed low (1, 11).

In general, potatoes have a medium to high GI (20).

However, the GI alone isnt the best representation of a foods effect on blood sugar levels, as it doesnt take into account portion size or cooking method. Instead, you can use the glycemic load (GL).

This is the GI multiplied by the actual number of carbs in a portion, divided by 100. A GL of less than 10 is low, while a GL greater than 20 is considered high. Generally, a low GI diet aims to keep the daily GL under 100 (11).

Both the GI and GL can vary by potato variety and cooking method.

For example, a 1 cup (150 gram) serving of potato may be high, medium, or low GL depending on the variety (11, 20):

If you have diabetes, choosing varieties like Carisma and Nicola is a better option to slow the rise of blood sugar levels after eating potatoes.

You can check the GI and GL of different types of potatoes through this website.

The way a potato is prepared also affects the GI and GL. This is because cooking changes the structure of the starches and thus how fast theyre absorbed into your bloodstream.

In general, the longer a potato is cooked the higher the GI. Therefore, boiling or baking for long periods tends to increase the GI.

Yet, cooling potatoes after cooking can increases the amount of resistant starch, which is a less digestible form of carbs. This helps lower the GI by 2528% (21, 22).

This means that a side of potato salad may be slightly better than french fries or hot baked potatoes if you have diabetes. French fries also pack more calories and fat due to their cooking method.

Additionally, you can lower the GI and GL of a meal by leaving the skins on for extra fiber, adding lemon juice or vinegar, or eating mixed meals with protein and fats as this helps slow the digestion of carbs and the rise in blood sugar levels (23).

For example, adding 4.2 ounces (120 grams) of cheese to a 10.2 ounce (290 gram) baked potato lowers the GL from 93 to 39 (24).

Keep in mind that this much cheese also contains 42 grams of fat and will add nearly 400 calories to the meal.

As such, its still necessary to consider the overall number of carbs and the quality of the diet, not just the GI or GL. If controlling weight is one of your goals, your total calorie intake is also important.

A low GI and GL diet can be beneficial for people with diabetes. Potatoes tend to have a medium to high GI and GL, but cooled cooked potatoes, as well as varieties like Carisma and Nicola, are lower and make a better choice for people with diabetes.

Although its safe for most people with diabetes to eat potatoes, its important to consider the amount and types you consume.

Eating potatoes both increases your risk of type 2 diabetes and may have negative effects on people with existing diabetes.

One study in 70,773 people found that for every 3 servings per week of boiled, mashed, or baked potatoes, there was a 4% increase in the risk of type 2 diabetes and for french fries, the risk increased to 19% (25).

Additionally, fried potatoes and potato chips contain high amounts of unhealthy fats that may increase blood pressure, lower HDL (good) cholesterol, and lead to weight gain and obesity all of which are associated with heart disease (26, 27, 28, 29).

This is particularly dangerous for people with diabetes, who often already have an increased risk of heart disease (30).

Fried potatoes are also higher in calories, which can contribute to unwanted weight gain (27, 29, 31).

People with type 2 diabetes are often encouraged to maintain a healthy weight or lose weight to help manage blood sugar and reduce the risk of complications (32).

Therefore, french fries, potato chips, and other potato dishes that use large amounts of fats are best avoided.

If youre having trouble managing your blood sugar levels and diet, speak with a healthcare provider, dietitian, or diabetes educator.

Eating unhealthy potato foods, such as chips and french fries, increases your risk of type 2 diabetes and complications, such as heart disease and obesity.

Although you can eat potatoes if you have diabetes, you may still want to limit them or replace them with healthier options.

Look for high fiber, lower carb, and low GI and GL foods like the following (33):

Another good way to avoid large portions of high carb foods is to fill at least half of your plate with non-starchy vegetables, such as broccoli, leafy greens, cauliflower, peppers, green beans, tomatoes, asparagus, cabbage, Brussels sprouts, cucumbers, and lettuce.

Lower carb replacements for potato include carrots, pumpkin, squash, parsnip, and taro. High carb but lower GI and GL options include sweet potato, legumes, and lentils.

Potatoes are a versatile and delicious vegetable that can be enjoyed by everyone, including people with diabetes.

However, because of their high carb content, you should limit portion sizes, always eat the skin, and choose low GI varieties, such as Carisma and Nicola.

In addition, its best to stick with boiling, baking, or steaming and avoid fried potatoes or potato chips, which are high in calories and unhealthy fats.

If youre struggling to make healthy choices to manage your diabetes, consult your healthcare provider, dietitian, or diabetes educator.

Read more:
Potatoes and Diabetes: Safety, Risks, and Alternatives - Healthline

Media Advisory

Friday, February 14, 2020

The longer a woman with gestational, or pregnancy-related, diabetes breastfeeds her infant, the lower her risk for developing type 2 diabetes later in life, suggests an analysis by researchers at the National Institutes of Health and other institutions. The study was conducted by Cuilin Zhang, M.D., Ph.D., of NIHs Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and colleagues. It appears in Diabetes Care.

In addition to health risks for mothers and babies, gestational diabetes increases the risk for type 2 diabetes 10 to 20 years after pregnancy. Type 2 diabetes increases the risk for heart disease, stroke and other health problems.

The researchers analyzed data from the Nurses Health Study II, a long-term study of risk factors for chronic diseases in women. Of more than 4,000 women in the study who had gestational diabetes, 873 developed type 2 diabetes over the course of 25 years. Compared to women with gestational diabetes who had not breastfed, those who breastfed for six to 12 months were 9% less likely to develop type 2 diabetes, those who breastfed for one to two years were 15% less likely, and those who breastfed for more than two years were 27% less likely.

The researchers suggested that clinicians may want to encourage patients with gestational diabetes to breastfeed if they are able to, to potentially reduce their type 2 diabetes risk.

The analysis was funded by NICHD with additional support from NIHs National Institute of General Medical Sciences.

The studys senior author, Cuilin Zhang, M.D., Ph.D., of the NICHD Epidemiology Branch, is available for comment.

Ley, SH. Lactation duration and long-term risk for incident type 2 diabetes in women with a history of gestational diabetes mellitus. Diabetes Care. 2019. https://doi.org/10.2337/dc19-2237.

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD leads research and training to understand human development, improve reproductive health, enhance the lives of children and adolescents, and optimize abilities for all. For more information, visit https://www.nichd.nih.gov.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

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Breastfeeding may reduce type 2 diabetes risk among women with gestational diabetes - National Institutes of Health

In a surprising study, Oregon State University researchers found that no matter how much stress they placed on mice from either a high-fat diet or strenuous exercise, the animals mitochondria were able to adapt and continue their normal processes.

The findings could have major implications for the study of diseases like diabetes, Parkinsons and Alzheimers, all of which are associated with an impairment in the breaking-down and clearance of damaged mitochondria.

Mitochondria are the structures that house cellular respiration, the process used to turn nutrients into energy. Dysfunction in mitochondria may lead to lower energy production, greater inflammation and tissue damage. Yet as central as mitochondria are to living organisms, scientists still dont know exactly what keeps them healthy or makes them unhealthy.

This study fits another piece into the puzzle, said OSU College of Public Health and Human Sciences researcher Matt Robinson, who co-authored the paper published last week in the FASEB Journal with Ph.D. student Sarah Ehrlicher.

It helps lay some future groundwork for how we can optimize (muscle and mitochondrial) health, to promote their health with diseases like obesity, diabetes, even some implications with aging conditions that we know have compromised mitochondria, Robinson said. This might provide some new pathways for how to improve the mitochondria and restore them.

The study looked at a specific pathway, called autophagy, through which cells recycle old mitochondria. Autophagy is thought to be impaired by a high-fat diet but activated by exercise. So Ehrlicher and Robinson intentionally blocked exercise-induced autophagy in the mice for a period of time, but continued exercising the mice.

They found that blocking a specific pathway to activate autophagy had no negative effect on mitochondrial function in the muscle of the mice.

Next they tried upping the ante, adding a high-fat diet alongside the exercise to further stress the mitochondria. And again, the mice were able to improve their mitochondrial function even without the autophagy pathway, Ehrlicher said, which shows that mitochondria have alternative pathways to stimulate recycling and adaptation.

She and Robinson were surprised by how adaptable the mitochondria seemed to be.

If these animals were given a high-fat diet, they got better at burning off those fats. If they were given just the exercise, they were able to make more mitochondria, which is good from an exercise perspective, Robinson said. And those adaptations seem to be very specific.

Future research will extend to human subjects, looking at how autophagy responds to diet and exercise in people, particularly those with obesity and diabetes.

While weight is a major risk factor for diabetes, research has shown that exercise is one of the strongest ways to help prevent or reverse development of the disease.

Even without changes in weight, exercise has this amazing ability to improve metabolic health, Ehrlicher said.

Even single sessions of exercise improve metabolism if a person is obese and, over time, can promote health.

With the current study as well as past research, Robinson and Ehrlicher have found that obese mice respond normally to nutrition and exercise, leading the researchers to conclude that there is no overt dysfunction or broken pathway; the muscle is just responding to the stimuli it is given, whether from diet or exercise.

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Mitochondria study could help boost understanding of diabetes and aging - The News Guard

Close to 10% of the U.S. population, around 30.3 million people, have diabetes. A new treatment delivery system created by bioengineers at the University of North Carolina and theUniversity of California, Los Angeles could help make life easier for them via a smart insulin patch thats about the size of a quarter. All a patient would need to use it would be to slap on a new patch at the start of the day, after which it would monitor and manage glucose levels for the next 24 hours.

It is smart and simple, which means it could help enhance the health and quality of life for people with diabetes, Zhen Gu, the study leader and a professor of bioengineering at the UCLA Samueli School of Engineering, told Digital Trends. It is a smart glucose-responsive insulin release device because it can respond to high blood sugar levels and release only the necessary insulin dosage, thus reducing the risk of hypoglycemia. This is a small and disposable device, so it is very simple and convenient to use; one can remove the patch any time to stop the administration of insulin.

The glucose-monitoring adhesive patch is covered in tiny microneedles, each one less than a millimeter in length. They are made from a glucose-sensing polymer and come pre-loaded with insulin. When the patch is applied, the microneedles penetrate the skin and start measuring blood sugar levels. If the glucose levels increase, the polymer triggers the release of insulin. At the point at which levels return to normal, the patchs insulin delivery also slows down. While this approach still involves pricking the patient with a needle, these needles are much smaller than regular needles. As a result, the patch is less painful than an ordinary injection.

So far, the patch has been successful in studies involving pigs. The researchers were able to use it to successfully control the glucose levels in these animals, which had Type I diabetes, for around 20 hours. Next, the researchers are hoping to progress to further trials, with the goal of commercializing their technology.

This patch has already been accepted by FDAs emerging technology programs for clinical trial applications, Gu said.

A paper describing the research was recently published in the journal Nature Biomedical Engineering.

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Smart microneedle insulin patch could make it easier to treat diabetes - Digital Trends