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Archive for the ‘Blindness’ Category

This cancer treatment gives patients night-vision, and we finally know why – Big Think

Friday, February 14th, 2020

In the early 2000s, it was reported that a certain kind of skin cancer treatment called photodynamic therapy, which uses light to destroy malignant cells, had a bizarre side effect: It was giving patients enhanced night time vision.

Rods and cones photoreceptors in a human retina.

Photo Credit: Dr. Robert Fariss, National Eye Institute, NIH / Flickr

"Seeing" happens when a series of receptors in the retina, the cones and rods, collect light. Rods contain a lot of rhodopsin, a photosensitive protein that absorbs visible light thanks to an active compound found in it called retinal. When retinal is exposed to visible light, it splits from rhodopsin. This then allows the light signal to be converted into an electrical signal that the visual cortex of our brains interprets into sight. Of course, there is "less light" at night, which actually means that light radiation is not in a domain visible to humans. It's at higher wavelengths (the infrared level) that retinal is not sensitive to. Hence, why we can't see in the dark like many critters can.

But the vision process can be activated by another interaction of light and chemistry. As it turns out, a chlorin e6 injection under infrared light changes retinal in the same way that visible light does. This is the cause of the unforeseen night vision side effect of the treatment.

"Molecular simulation" is a method that uses an algorithm that integrates the laws of quantum and Newtonian physics to model the functioning of a biological system over time. The team used this method to mimic the biomechanical movements of individual atoms that is, their attraction or repulsion to one another along with the making or breaking of chemical bonds.

"For our simulation we placed a virtual rhodopsin protein inserted in its lipid membrane in contact with several chlorin e6 molecules and water, or several tens of thousands of atoms," Monari explained to CNRS. "Our super-calculators ran for several months and completed millions of calculations before they were able to simulate the entire biochemical reaction triggered by infrared radiation." In nature, this phenomena occurs within fractions of a nanosecond.

The molecular simulation showed that when the chlorin e6 molecule absorbs the infrared radiation, it interacts with the oxygen present in the eye tissue and transforms it into reactive, or singlet, oxygen. In addition to killing cancer cells, "singlet oxygen" can also react with retinal to enable a slightly enhanced eyesight at night, when light waves are at the infrared level.

Now that researchers know why the "supernatural" side effect occurs, they may be able to limit the chance of it happening to patients undergoing photodynamic treatment. Thinking further out, the researchers hope for the possibility that this chemical reaction could be harnessed to help treat certain types of blindness and sensitivity to light.

Ultimately, researchers say that this has been a big flex for the power of molecular simulations, which can give us astonishing scientific insights like this.

"Molecular simulation is already being used to shed light on fundamental mechanisms for example, why certain DNA lesions are better repaired than others and enable the selection of potential therapeutic molecules by mimicking their interaction with a chosen target," Monari told CNRS.

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Mutation Spectrum of Stickler Syndrome Type I and Genotype-phenotype Analysis in East Asian Population: a systematic review. – Physician’s Weekly

Friday, February 14th, 2020

Stickler syndrome is the most common genetic cause of rhegmatogenous retinal detachment (RRD) in children, and has a high risk of blindness. Type I (STL1) is the most common subtype, caused by COL2A1 mutations. This study aims to analyze the mutation spectrum of COL2A1 and further elucidate the genotype-phenotype relationships in the East Asian populations with STL1, which is poorly studied at present.By searching MEDLINE, Web of Science, CNKI, Wanfang Data, HGMD and Clinvar, all publications associated with STL1 were collected. Then, they were carefully screened to obtain all reported STL1-related variants in COL2A1 and clinical features in East Asian patients with STL1.There were 274 COL2A1 variants identified in 999 patients with STL1 from 466 unrelated families, and more than half of them were truncation mutations. Of the 107 STL1 patients reported in the East Asian population, it was found that patients with truncation mutations had milder systemic phenotypes, whereas patients with splicing mutations had severer phenotypes. In addition, several recurrent variants (c.3106C>T, c.1833+1G>A, c.2710C>T and c.1693C>T) were found.Genotype-phenotype correlations should certainly be studied carefully, contributed to making personalized follow-up plans and predicting prognosis of this disorder. Genome editing holds great potential for treating inherited diseases caused by pathogenic mutations. In this study, several recurrent variants were found, providing potential candidate targets for genetic manipulation in the future.

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Mutation Spectrum of Stickler Syndrome Type I and Genotype-phenotype Analysis in East Asian Population: a systematic review. - Physician's Weekly

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High blood pressure signs : The worrying symptom in your eyes that could signal your risk – Express

Friday, February 14th, 2020

High blood pressure relates to ones force of blood against the arteries. The force is a result of the blood pumping out of the heart and into the arteries as well as the force created as the heart rests between heartbeats. When the blood moves through the body at a higher pressure, the tissue that makes up the arteries will begin to stretch and will eventually become damaged. This leads to many problems over time with the condition then affecting the eyes.

High blood pressure can occur after the blood pressure has been consistently high over a prolonged period of time.

A persons blood pressure levels can be affected by a lack of physical activity, being overweight, having a diet with too much salt or leading a stressful lifestyle.

If left untreated, a blood pressure of 180/120 or higher results in 80 percent chance of death within one year, with an average survival rate of ten months.

Prolonged, untreated high blood pressure can also lead to heart attack, stroke, blindness and kidney disease.

READ MORE: How to live longer: The best diet proven to increase life expectancy and ward off cancer

Spotting the early warning signs of the dangerous condition is crucial and developing this symptom in your eyes could mean youre at risk of developing high blood pressure.

If a person has high blood pressure left untreated it may cause a hypertensive crisis.

A hypertensive crisis is divided into two categories: urgent and emergency.

In an urgent hypertensive crisis, the good pressure is extremely high, but the doctors dont suspect there has been any damage to the organs.

In an emergency hypertensive crisis, the blood pressure is extremely high and has caused damage to the organs.

Signs of a hypertensive crisis may include severe chest pain, severe headache and nausea.

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What is hypertensive retinopathy?

The retina is the tissue layer located in the back of the eye.

This layer transforms light into nerve signals that are then sent to the brain for interpretation.

When blood pressure is too high, the retinas blood vessel walls may thicken. This may cause the blood vessels to become narrow, which then restricts blood from reaching the retina.

In some cases, the retina becomes swollen.

Over time, high blood pressure can cause damage to the retinas blood vessels, limit the retinas function and put pressure on the optic nerve, causing vision problems and potentially leading to blindness.

This condition is called hypertensive retinopathy.

Symptoms include reduced vision, eye swelling, bursting of a blood vessel or experiencing double vison accompnaied by headaches.

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High blood pressure signs : The worrying symptom in your eyes that could signal your risk - Express

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How MANI aids differently abled to manage their cash transactions – Moneycontrol

Friday, February 14th, 2020

Here is a look at how RBIs MANI app has been designed to help the differently-abled manage their cash transactions with greater ease.

As per the National Blindness and Visually Impaired survey released by Union Health Minister Dr Harsh Vardhan in 2019, the number of people suffering from blindness has declined from 12 million in 2006-07 to 4.8 million last year. Thats certainly a welcome news.

Add to this, to aid the visually challenged in the country, in January 2020, the Reserve Bank of India (RBI) introduced a mobile app that can identify a currency notes denomination. The Mobile Aided Note Identifier, or MANI, is freely available for Android and iOS operating systems and also works offline after installation.

It is a great help for the differently abled, especially after the introduction of new notes since demonetization. These banknotes from the Mahatma Gandhi series contained features, like tactile markings and variable note sizes, to help the visually challenged. However, it still resulted in mix-ups during their daily dealings.

MANI app is designed to make it easier for the differently abled to manage their cash transactions independently. Want to know more about the app?

Exclusive offer: Use code "BUDGET2020" and get Moneycontrol Pro's Subscription for as little as Rs 333/- for the first year.

First Published on Feb 12, 2020 07:40 pm

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Eye doctor leads the way to children’s clearer vision across the Caribbean – University of Miami

Friday, February 14th, 2020

A University of Miami ophthalmologist is spearheading an effort to improve pediatric vision screenings in the Caribbean Basin.

A few years ago, Dr. Alana Grajewski was having dinner with an ophthalmologist visiting the University of Miamis Bascom Palmer Eye Institute to train with her in pediatric glaucoma surgery, when he admitted a realization he had in the operating room earlier that day.

The physician from the South American coastal nation of Suriname was unsure he would even get a chance to perform the techniques Grajewski had taught him because some children show up to his office in such poor condition that it is too late to repair their vision. If left untreated, glaucoma can cause blindness in children.

Although the message was disheartening, after the doctors confession, Grajewski began researching the problem more. She learned that vision impairment and blindness is four times higher in the Caribbeanalthough in South America, Suriname culturally is considered to be a Caribbean nationthan it is in the United States, and she saw an opportunity to help.

In the Caribbean, there is very little that has been done in the way of identifying childrens eye disease early, and if you dont identify these problems, it becomes a more expensive and more damaging problem down the road, said Grajewski, who has been treating children as an ophthalmologist for 30 years and who directs the Samuel and Ethel Balkan International Pediatric Glaucoma Center at the Bascom Palmer Eye Institute. But if you are able to catch something and fix it, youre improving their ability to function in school and in the world.

Starting with Suriname, Grajewski is now leading an effort called the Pediatric Preventable Blindness (PPB) initiative to help eradicate vision loss in children. Currently, there is no formal vision screening in Suriname until children reach the age of 5. Yet by working with her colleagues at Bascom Palmer, other U.S. experts in the fields of ophthalmology and public health, as well as the University of Suriname, Grajewski came up with a strategy to screen childrens vision earlierby doing it when they get their vaccines. If it is implemented fully, this model would allow Suriname doctors to mitigate vision problems before they worsen, she said.

The Caribbean loves this concept, Grajewski added. When we presented our model at a recent ophthalmology conference at the University of West Indies, ophthalmologists throughout the Caribbean were thrilled.

With early detection and treatment, more children who need glasses at an early age will be able to get them, and children with more severe vision impairments like pediatric glaucoma can be referred to an ophthalmologist, said Matthew Javitt, research fellow. With surgery, pediatric glaucoma has an 80 percent to 90 percent chance of restoring a childs vision. And with the vision screening model Grajewskis team designed, it will only add four minutes to a familys vaccination appointment.

The PPB initiative began with a trip to Suriname last May when Dr. Christina Dowell, a resident at the University of Miami Miller School of Medicine, visited several clinics and trained health care workers in how to use vision screening equipment. For children younger than six months, an arc light is used, which is a device that can be attached to a mobile phone to take a photo of the eye and detect any abnormalities. For children older than six months, a device called a spot vision screener is used to detect any impairments. While she was there, Dowell visited clinics near the countrys capital of Paramaribo with Dr. Denise Doelwijt, a University of Suriname ophthalmologist, and trained health care workers on how to conduct vision screenings. In July, another team from Bascom Palmer visited four clinics in Suriname. At the end of this month, Doelwijt, along with Bascom Palmer researchers Dr. Eleonore Savatovsky and medical student Adriana Grossman, are planning to expand their reach to visit 17 clinics across the country.

We were looking to put a screening in as part of the existing infrastructure, which was why we chose the vaccination process where there is 95 percent participation from parents in Suriname, said Javitt, who helped develop the initiative.

As Surinames only current pediatric eye surgeon, Doelwijt is often inundated with young patients who have not even gotten an eye screening when they arrive in her office. In December, she had a six-month wait to see new patients, she reported.

This will make the wait time a little shorter because children will have already been screened elsewhere, she said.

Doelwijt is a surgeon at the Suriname Eye Centre, which is part of the academic hospital for the University of Suriname. She has gathered a team of medical students and is collaborating with Grajewski to implement the initiative at an expanding number of clinics across the nation of more than 500,000 people. Doelwijts students also will help University researchers collect data that can evaluate if the initiative is improving the diagnosis process. However, Doelwijt is confident the model will help Surinames physicians.

If this can help us operate earlier on the kids who need it, patients would get a better visual end result, she said.

Since vision develops in the brain from what a child can physically see, Doelwijt and Grajewski said that the faster vision problems are corrected, the best chance a child has to either improve his or her vision or avoid blindness. Children grow into their vision, so if they are seen later, or not evaluated properly, they can still develop poor vision even if they have a beautiful eye, Doelwijt said.

After a model is working in Suriname, Grajewski wants to implement a similar PPB program in Trinidad, Jamaica, and Barbados through the Universitys new partnership with the University of the West Indies.

In December, Bascom Palmer hosted a conference for physicians from across the hemisphere to learn about the initiative and discuss ways to implement a similar model in other countries that need a better way to conduct vision screenings. Ophthalmology experts from several universities in the region attended to learn about the initiative.

Once its in place, this effort will be self-sustainable and will be part of the policy in these countries, said Grajewski.

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Barton Foundation gives over $360000 to community health improvements – South Tahoe Now

Friday, February 14th, 2020

Jenna Palacio, Barton Health

SOUTH LAKE TAHOE, Calif. The Barton Foundation provided more than $360,000 in funding during 2019, delivering a profound community impact made possible by philanthropy and donor generosity over the year. Medical equipment, new technology, care provider education, and support, expanding access to mental and behavioral health services, and funding for local organizations were all aspects of the Barton Foundations scope of giving last year, as part of its commitment to community well-being through Barton Health.

More than one-third of the Barton Foundation investments in 2019 went to purchasing medical equipment, bringing in new technology, and offering training and education opportunities for care providers. Some of the new equipment and technology upgrades include an additional infant warmer in the Barton Family Birthing Center; a specialized camera to detect retinopathy the leading cause of blindness in the United States; ventilators to support patients with chronic respiratory conditions at home; and medical technology to allow for sharper images guiding wrist and hand orthopedic surgeries.

Bartons 2018 Community Health Needs Assessment identified mental and behavioral health as the most pressing health issue of the area. The Barton Foundation dedicated sizable funding in 2019 to community organizations working to address this issue. Additional support provided by the Foundation last year went to improving access to mental and behavioral health services, and renovating two Emergency Department rooms at the hospital for patients in crisis.

As part of the Barton Foundations vision to positively impact the health of the community by providing financial resources, funding was given to an array of local support, education and health improvement efforts. Financial aid was given to cancer patients for access to Bartons Cancer Support Services. The Foundations 2019 grant cycle awarded $50,000 to 15 local care-based organizations. Further training and medical equipment was given to community police, fire, and educators for the Stop the Bleed program, which trains first responders how to care for trauma victims.

The Barton Foundations mission is to inspire philanthropy for the health of the community. Up next in the Barton Foundations annual programming, Pink Heavenly will take over Heavenly Mountain Resorts California Base Lodge on March 21, celebrating fundraising efforts that directly benefit wellness programs through Bartons Cancer Support Services.

For more information, giving, and upcoming events with the Barton Foundation, visit bartonhealth.org/foundation.

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Sophie Wessex to spend Valentines Day APART from Prince Edward – because of the Queen – Express.co.uk

Friday, February 14th, 2020

Sophie, who married Prince Edward in 1999, is set to leave the beloved members of her family behind tomorrow, her royal diary shows. According to the official royal schedule, the Countess of Wessex will visit Germany on Valentines Day, representing the Queen.

This means Sophie will have to skip Valentines Day celebrations this year.

Her husband, the Earl of Wessex, is attending an event in Harrogate today, and doesnt look set to have any engagement lined up in Germany over the next few days.

Following her day in Germany, Sophies diary is free of engagements until February 26.

This is likely due to the fact that the Countess children, Lady Louise Windsor and James, Viscount Severn, are on their half-term break and Sophie wants to spend as much time as possible with them.

Upon returning to work, Sophie will attend a reception at St Jamess Palace for the International Agency for the Prevention of Blindness in her role as Global Ambassador.

The prevention of blindness is one of the main areas of interest of Sophies royal work, together with female empowerment.

READ MORE:Sophie, Countess of Wessex: How did she assert self as royal?

While Sophie and Edward dont look set to spend Valentines Day together, the couple will likely delay the celebrations and carry them out during the weekend.

Edward is the Queens youngest child and the only one out of the monarch and Prince Philips four children who didnt get a divorce.

Sophie and Prince Edward met at a tennis match in 1993 and dated for six years before tying the knot at St Georges Chapel, the same church where Meghan Markle, Princess Eugenie and Lady Gabriella Windsor got married between 2018 and 2019.

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The Wessexes nuptials were televised, and as many as 200 million viewers from all over the world tuned in to witness their love.

Ahead of his big day, Prince Edward said: We manage to have a good laugh about things most of the time, and we happen to love each other, which is the most important thing of all.

While Sophie and Edward may be spending tomorrow apart, other royals look set to show their romantic traits to their other halves.

According to royal expert Katie Nicholl, Prince William is a romantic deep down and he will likely use tomorrow as an excuse to spend more time with Kate, Duchess of Cambridge.

Ms Nicholl told OK! magazine: Kate and William are clearly very happy in their marriage and it shows.

Theyre both affectionate and these days theyre not afraid to show that in public.

Theres a very natural chemistry and warmth between them.

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Sophie Wessex to spend Valentines Day APART from Prince Edward - because of the Queen - Express.co.uk

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WVU project works to prevent blindness in diabetic patients – WDTV

Wednesday, January 29th, 2020

MORGANTOWN, W.Va. (WDTV)-- A West Virginia practice-based program with the help of other officials at WVU work to help bring awareness for diabetics.

With the project, staff across the state train to find early detection for diabetic retinopathy.

"Vision loss, more loss of quality of life so we're really trying to get it as early as possible so we're really able to keep the patients functioning in their normal life styles as long as possible," Stacey Whanger said.

Patients can go see a doctor where a camera will take a picture of their eyes. Those images are sent over to the WVU eye institute.

"The retina ophthalmologist will grade based on the severity of the disease and any other pathology they might find then later sent back to the health care provider," Whanger said.

For diabetic patients, doctors recommend everyone gets an exam once a year, especially if patients have vision loss that can't be fixed with glasses.

"Then we can do some treatment to help that blindness. so it's really important to get the screening done we can then prevent the blindness is someone is having damage due to their diabetes," Treah Haggerty said.

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Modified HoloLens helps teach kids with vision impairment to navigate the social world – TechCrunch

Wednesday, January 29th, 2020

Growing up with blindness or low vision can be difficult for kids, not just because they cant read the same books or play the same games as their sighted peers; Vision is also a big part of social interaction and conversation. This Microsoft research project uses augmented reality to help kids with vision impairment see the people theyre talking with.

The challenge people with vision impairment encounter is, of course, that they cant see the other people around them. This can prevent them from detecting and using many of the nonverbal cues sighted people use in conversation, especially if those behaviors arent learned at an early age.

Project Tokyo is a new effort from Microsoft in which its researchers are looking into how technologies like AI and AR can be useful to all people, including those with disabilities. Thats not always the case, though it must be said that voice-powered virtual assistants are a boon to many who cant as easily use a touchscreen or mouse and keyboard.

The team, which started as an informal challenge to improve accessibility a few years ago, began by observing people traveling to the Special Olympics, then followed that up with workshops involving the blind and low vision community. Their primary realization was of the subtle context sight gives in nearly all situations.

We, as humans, have this very, very nuanced and elaborate sense of social understanding of how to interact with people getting a sense of who is in the room, what are they doing, what is their relationship to me, how do I understand if they are relevant for me or not, said Microsoft researcher Ed Cutrell. And for blind people a lot of the cues that we take for granted just go away.

In children this can be especially pronounced, as having perhaps never learned the relevant cues and behaviors, they can themselves exhibit antisocial tendencies like resting their head on a table while conversing, or not facing a person when speaking to them.

To be clear, these behaviors arent problematic in themselves, as they are just the person doing what works best for them, but they can inhibit everyday relations with sighted people, and its a worthwhile goal to consider how those relations can be made easier and more natural for everyone.

The experimental solution Project Tokyo has been pursuing involves a modified HoloLens minus the lens, of course. The device is also a highly sophisticated imaging device that can identify objects and people if provided with the right code.

The user wears the device like a high-tech headband, and a custom software stack provides them with a set of contextual cues:

Other tools are being evaluated, but this set is a start, and based on a case study with a game 12-year-old named Theo, they could be extremely helpful.

Microsofts post describing the system and the teams work with Theo and others is worth reading for the details, but essentially Theo began to learn the ins and outs of the system and in turn began to manage social situations using cues mainly used by sighted people. For instance, he learned that he can deliberately direct his attention at someone by turning his head towards them, and developed his own method of scanning the room to keep tabs on those nearby neither one possible when ones head is on the table.

That kind of empowerment is a good start, but this is definitely a work in progress. The bulky, expensive hardware isnt exactly something youd want to wear all day, and naturally different users will have different needs. What about expressions and gestures? What about signs and menus? Ultimately the future of Project Tokyo will be determined, as before, by the needs of the communities who are seldom consulted when it comes to building AI systems and other modern conveniences.

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Modified HoloLens helps teach kids with vision impairment to navigate the social world - TechCrunch

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PFFB, Eye Donation Campaign striving against blindness – The News International

Wednesday, January 29th, 2020

PFFB, Eye Donation Campaign striving against blindness

Islamabad : Former federal secretary Abdullah Yousaf who is chairman of Pakistan Foundation Blindness said that since the aim of PFFB and Eye Donation Campaign is to restore eyesight of blind persons, both organisations have agreed to make joint efforts. He expressed their views during the meeting of the board of trustees of PFFB.

PFFB is the pioneer organization in Pakistan working for the relief of blind persons it is involved in research work in collaboration with retina international. The foundation is also carrying out different projects to help blind and disabled persons in the country. The meeting was attended by trustees and CEO of foundation Mrs. Nasrin Mansoor, Chief Co-ordinator Rabail Pirzada, Ex Fed Sec Information Syed Anwer Mehmood, Company sec Lubna Aftab.

Chairman Eye Donation Campaign Dr. Mazhar Qayyum briefed the members about objective and functioning of the campaign. He said that 3 Lac blind persons are on waiting list for corneal grafting operation. Corneas are obtained from the Eye of Dead Persons who has given consent during life time.

He said the campaign is to make people aware that they can help restore eyesight of so many peoples by signing the Consent Form. Dr. Mazhar Qayyum said that we all need to put together our efforts since to get 3 lac corneas as donation is a huge target. He said multiple social organisations should join hands to fulfil the great objective.

The members of PFFB board assured Dr. Mazhar Qayyum to support him actively in this noble cause.

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1 lakh kids born in Bangladesh with blindness risk every y… – United News of Bangladesh

Wednesday, January 29th, 2020

Ophthalmologists here have said over 100,000 children born in Bangladesh every year face the risk of blindness and they may lose the eyesight anytime if not given proper treatment.

They highlighted this at a roundtable discussion titled ROP Prevention & Treatment: Scope & Potentials at Press Institute Bangladesh (PIB) seminar room jointly organised by Orbis International and PIB on Monday.Referring to statistics of the United Nations, Orbis Senior Medical Specialist Dr Lutful Husain in his keynote presentation said around 3 million babies are born in Bangladesh every year on average.

Of them, at least 600,000 children are born prematurely. Of these premature babies, 20-22 percent kids face the risk of being affected with retinopathy of prematurity (ROP), he added.

PIB Director General Zafar Wazed, Bangladesh Medical and Dental Council (BMDC) President Prof Mohammad Shahidullah, Orbis International Country Director Dr Munir Ahmed, OBGyn Society of Bangladesh ex-President Prof Rowshan Ara, Bangladesh Eye Hospital Consultant Dr Kazi Shabbir Anwar, among others, spoke at the programme.

According to ophthalmologists, ROP is a vaso-proliferative disorder affecting the avascular retina of babies who are born prematurely -- before 34 weeks of gestation.

Dr Lutful Husain said most parts of the country lack ROP service facilities as they are concentrated mainly on divisional cities and large district towns.

BMDC President Shahidullah laid emphasis on devising a short-term strategy to overcome the shortcoming.

Zafar Wazed stressed the need for building more close relations between media and health institutions for raising awareness.

Leading ophthalmologists, neonatologists, gynecologists and obstetricians, senior government officials, representatives from eye care institutions, non-government organisations, and other stakeholders took part in the discussion.

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UWF researcher earns grant to study retina regeneration in fish – UWF Newsroom

Wednesday, January 29th, 2020

The research will focus on using Clustered Regularly Interspaced Palindromic Repeats, or CRISPR, genome-editing techniques to explore how zebrafish regenerate the retinal cells that receive light and start the visual process.

Taylor said the research could eventually have applications for treating blindness in humans.

(MiR-18a) might be extremely important for starting the regeneration process and at least helping to produce new photoreceptor cells, Taylor said. Thats really what we want to get at because in humans a lot of the retinal diseases destroy photoreceptors. So, we want to find ways to regenerate those cells in humans so that vision can be restored.

Zebrafish can fully regenerate cells in their eyes even after extensive damage.

In other animals, including mammals, damage to the retina causes permanent blindness, but zebrafish can fully recover from this, Taylor said. Otherwise, our retinas are almost identical in terms of how they work and how theyre structured.

Taylor has used CRISPR to create zebrafish without MiR-18a, a molecule that regulates regeneration in the eye, to see how their vision recovers in its absence.

Fish without this molecule have an exaggerated regeneration response, Taylor said. They produce more new cells and photoreceptors than normal fish would. We think this process is critical for regulating retinal regeneration.

Taylor has studied retinal regeneration at UWF for more than three years.The grant will fund three years of work and will support research positions for undergraduate and graduate students.

For more information about the UWF Department of Biology, visit uwf.edu/biology.

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What having a heart attack taught me about Brexit – The Guardian

Wednesday, January 29th, 2020

Something can be massive without being obvious, as I learned by having a heart attack. The symptoms should not have left doubt: sudden, severe chest pain; a burning lash down the left arm; air refusing to enter the lungs; a vibrating sense of ill-being, the world turning sour and dark.

Still I hesitated before getting help. At some level I knew what was up, but really not wanting a heart attack seemed like a compelling reason why I wasnt having one. Forty-five seemed a bit premature for that sort of thing. Later, recovering in hospital, I was described as young with a frequency that would be flattering in other contexts.

In hindsight, the symptoms had started a lot earlier. The feeling in my chest was an extreme variant of tightness I had felt before while running, and dismissed as unfitness. (Turns out: angina.) Such is the awesome power of denial, a psychological term cheapened by overuse. We are always describing others and even deprecating ourselves for being in denial of the smallest things, which is itself a kind of denial. Admitting shortsightedness around minor flaws is a way to avoid admitting blindness to much worse.

I was still hooked up to cardiac monitors and full of morphine, barely an hour after the insertion of two stents, when the metaphorical comparisons first presented themselves. The Labour party had ignored vital warning signs for years, failing to change course when avoidance of calamity was still available. So too had Britains pro-European campaign. I wont stress the point too hard, being on doctors orders to minimise stress of all kinds. The compulsion to turn even my own medical emergency into a political analogy flagged a lifestyle habit in need of healthy adaptation. A month of convalescence has taught me to care differently. Not less, but less angrily.

It pushes the metaphor too far to say that Brexit broke my heart. I was culturally and emotionally attached to the European project and still believe UK involvement has improved this country. It will hurt on Friday night when EU membership ends, but not as much as it hurts when a blocked artery cuts off blood to the left ventricle. Having survived one of those experiences, I am palpably more relaxed facing the other one. It also helps to understand those hearts that will leap at 11pm on 31 January.

That sensitivity does not include deference to asinine Tory MPs licking their lips and commemorative stamps with triumphant relish. One of their number, Mark Francois, says he will stay up all night to watch the sun rise on a free country. Neither he nor any of his co-fetishists has satisfactorily explained what, in practice, they will be free to do on Saturday that is forbidden today.

In truth, the measurable liberties available that dawn will be European ones, preserved thanks to a transition period that the all-nighter Brexit celebrants resent as deferral of a greater rupture.

But there I have lapsed into another bad old habit. Remainers lost the argument with arch, eye-rolling negativity. In 2016 the pro-European case was made exclusively in terms of loss forfeited growth, shrunken prestige, jettisoned jobs while the leavers advertised gains. After the referendum, those Brexit promises were assailed by fact-checkers, myth-busters, expert debunkers, but what was the counter offer? What would leavers get in exchange for surrendering a prize for which they had voted, to which they were democratically entitled and which they had not yet received?

On we went, rubbishing the idea that Brexit was a bounty of freedom, sovereignty and control, irritating more than we converted, until Boris Johnson came along to lift the siege. By December, the liberation he could realistically offer voters wasnt from Europe any more, it was from the argument encircling them. It was from us, the remainers.

Johnsons winning formula was to downgrade the promise of Brexit from reward to relief, which was easier to deliver and still sounded marvellous. His opponents complain that the Boris brand of optimism is fraudulent, but that doesnt matter when it is unrivalled in the market.

Pro-Europeans got stuck in a quicksand of nostalgia, rosily tinting the epoch of unchallenged EU membership as a golden age of moderation. It was easy to see it that way as the Conservative party waged war on economics and geography, making dissidents of its sanest MPs. But the remainer lament often sounded like privilege drowning in self-pity, which isnt any more attractive in politics than in other walks of life. We had facts on our side, certain ours was the rational position. The failure to change minds just seemed to prove that rationality itself was in peril. Donald Trump marauding from the White House supported that hypothesis. But for all the solidity of our claims, the case we built from them was hypothetical. Brexit hadnt happened yet, so we couldnt convincingly call it a disaster. Nothing, it seemed, was really happening, despite the frenzy in Westminster.

The whole of politics between the referendum and the 2019 election seems to have been conducted in zero gravity. Arguments that should have weight had none and any crazy notions, once hurled, could fly around with infinite momentum. Only in the unique conditions of space flight could a man built like Johnson cavort like a gymnast. The landing begins on Friday. The country will soon feel the friction of re-entry into a thicker political atmosphere.

The prime minister is already feeling the pressure of earthly decisions: high-speed rail; Chinese involvement in 5G infrastructure; the divergent pulls of strategic cosiness with Donald Trump and trade continuity with Europe. Each choice makes new enemies and limits future choices. Johnsons method so far has been to campaign against the very idea that government is difficult. It is certainly easier without effective opposition, but that advantage cannot endure forever.

The price of victory on a promise to get Brexit done is getting it done. On Friday we cross the threshold where Brexit must breathe the same air as other political projects. It sheds the immunity of abstraction and enters the realm of evidence. There will be no bracing inrush of liberty to get leaver hearts pumping, and no sudden cataclysm to vindicate remainers. If ending EU membership proves to be a mistake it will be a gradual tightening, a slow burn; the kind of problem that is easier to deny than to own. Massive, not obvious.

Rafael Behr is a Guardian columnist

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The Most Important Social Skill You Can Master, According to a Harvard Business School Professor – Worth

Wednesday, January 29th, 2020

Laura Huang on the keys to emotional intelligence.

Self-effacing and funny, Harvard Business School professor Laura Huang hardly exudes the cutthroat mien you might expect from her impressive credentials, which include a PhD in management from the University of California, Irvine and an INSEAD MBA. That kind of surprise is one of the key points of her new book: In Edge: Turning Adversity into Advantage (Portfolio, January 2020), Huang argues that all of us can turn hardships into advantages, if we do so with authenticity. Laced with anecdotes like the time Huang was nearly thrown out of Elon Musks office and examples of unexpected triumphs from leaders like the Soros Funds CIO Dawn Fitzpatrick, Edge is Huangs primer for how and why entrepreneurs should best employ tools like emotional intelligence. She spoke with Worth about how shes done this in her own life, what a Texas gas station chain has in common with the most luxurious Swiss watch companies and why delight is such a key element of success.

Q: You write a lot about social skills. What are the most important ones, and how are they best deployed? A: When we think about social skills, we often think about things like being charismatic and being able to influence others, but social also means that we have a deep sense of who we are, as well as a deep sense of who our counterpart is, and where theyre coming from.

When were able to do that, were able to influence and interact in a much deeper and much more authentic way. We tend to think of interacting with other people almost as something manipulative, but its not. People are going to have first impressions of us, regardless of whether or not we guide them to who we authentically are. The more that were able to deploy those skills, the better off those relationships will inevitably be.

Can those skills be learned? Not everyone has a great read on their own perceptions, let alone how other people perceive them. It absolutely can be learned, but it takes a lot of mistakes and failures and embarrassment, and not everyone is willing to put themselves out there. Getting these types of social skills really depends on being able to laugh at yourself and to find ways to help others laugh at themselves. Its really important that were not only more self-aware, but also more aware of other people and how they might be making mistakes and feeling embarrassed.

Tell me about your career path.I was an engineer by training, worked in engineering, worked in consulting, was an investment banker for a while. The topics that I chose to study, intuition and gut feel, were based on experiences that I had prior to becoming an academic. People told me, Dont pursue these ideas. Its career suicide. I think its something that everyone was curious about, but no one wanted to be the person to try and quantify something as obtuse as gut feel. To some extent, my nontraditional path gave me the ability to study it.

What is advantage blindness?Advantage blindness really means not being able to see the privileges or advantages that we have. The more we obtain success, the more important it is to be aware of our advantage blindness. But the more successful we become, the more likely we are to forget our uphill climb to our position, the feelings and the thoughts that we had to get there, and in turn, the more we are blind to our situations of success and achievement. We all have advantage blindness to some extent.

When did you start writing about the idea of privilege, which has become such a loaded term? Over a decade ago, I was studying organizations and looking at people who were feeling like they were constantly facing barriers and feeling disadvantaged in terms of not getting promoted or placed on coveted projects. They were leaving those organizations and going into the startup world, where they could call their own shots. But they still felt just as discouraged and frustrated, because they still were facing disadvantages, and they still were facing biases and being underestimated.

Because were in a socially embedded system, were always going to have that. The privilege piece is that there are certain people who naturally seem to be in a position of privilege based on their education, based on who they are, based on the perceptions that other people have of them. I always said that when you dont have that privilege, you can make your own privilege. But even that had this loaded connotation.

I still think that privilege doesnt necessarily have to be a negative thing. It can mean youve earned it, but it can also mean that you have some sort of an unfair advantage, and that unfair piece is what bothers us. The advantage piece doesnt bother us when its based on a value we provide or a way that we enrich. When I break up privilege and disentangle the unfair piece from the advantage piece, I find that we then understand privilege in a different way.

Speaking of unfair situations, I was struck by your description of your high school math teacher, who prevented you from joining the advanced class, even though you excelled at math. Still, you write that he remains your favorite teacher.

It clearly was bias, but as a 14 year-old, I didnt quite get that yet. But even looking back, Im so grateful to that math teacher because I learned more from him than I had learned from any other teacher that I had had, even ones that treated me very, very fairly, which suggests that this is a really complicated thing.

Its a personal thing when were underestimated by people like our math teachers. But when I look beyond that and see the greater lessons, Im able to say, look, its not quite that cut and dried.

A lot of times we talk about the system, and making sure that its meritocratic, without bias and discrimination. I totally agree with that premise, but at the same time, its important to understand that systems are not going to always change. If they do change, theyre not always going to change in the ways that we think they should, or that they ideally should.

Not only is there this element of needing to change things from the outside in, but we also need to empower people from within so that we can change things from the inside out.

Had we eliminated this teacher from the teaching system, we also would have been losing a brilliant educator who provided a lot of value within the educational system.

Youre an Asian American woman. I know that biases can come in all forms, but Im wondering, do they all have equal weight in influencing behavior?

Thats a great question. What I try and emphasize is that theres the typical cast of characters that we bring up, like being women, people of color, our sexual orientation and class, but everybody has something, some hang up, or something that people perceive you as.

We should not be in a bias Olympics to see who has it worse, because no ones ever going to win that. Were all going to be able to feel personally affronted in different ways.

I remember Ronan Farrow saying that he constantly hears, Oh, youre the son of Mia Farrow. Youre only getting access to these people because of who you are. Thats his something. He has to constantly show that hes competent, and that his writing is good and that somehow, he would have still gotten to where he is now. Maybe he would have had a different path, or a different trajectory, but he still would have gotten to that ultimate endpoint, regardless of those other things.

How do you advise employees to overcome their own implicit biases, as well as the biases projected onto them?

The overarching thread of my book is understanding that, while hard work is critical, it alone is not enough, because there are all of these perceptions, attributions and implicit stereotypes and perceptions that are our own, as well as ones that are projected onto us. We dont always have the opportunity to show how we enrich and provide value.

How can we get that initial opening into having somebody seeing us for who we are? How can you delight somebody else? How do you get that catalyst so that somebody stops and says, Huh, I didnt quite think that about this situation or about you. And then once you get that opening, you can really show how you enrich and continue to guide. Companies have to do this all the time, to stay nimble and show that theyre relevant in the market. People can do this as well.

So what are what you call the basic goods that you would implement as part of that strategy?

These are your superpowers, the central value or competency that you provide. This takes a lot of thought and self-reflection, and my book is not a prescriptive recipe for how to gain your edge, its a perspective on how to think. And the more personal you make it, and the more you think about your own basic goods and your own ways of guiding, the more effective youre going to be at getting your edge. Its really a way for you to understand how you add value to various scenarios and target audiences.

Do you have examples of companies or individuals that have mastered this?

Buc-ees, the Texas gas station chain. When they started, their basic goods were ice, cheap gas and clean bathrooms. What they realized was that when people are driving on road trips, they stop at gas stations to use the bathroom, to get gas and, in Texas where they started out, ice for their soft drinks. They built on those basic goods, and now theyre just this spectacular organization that has the longest carwash in America, the cleanest bathrooms in America, their own branded merchandise, and branded food and all of these things that they built off of what were their basic goods.

You also write about the Swiss watch industry, and how it flipped the narrative of being a business losing to technology to their advantage.

My colleague Ryan Raffaelli studied the Swiss watch industry in-depth. He analyzed companies like Hublot and Montblanc and founders such as Jean-Claude Biver, who really had a vision for technical tradition and advanced engineering, which started from being enamored by model trains and electric trains.

Biver really understood that something that was once an advantage, the privilege that they once had, was changing and that now they were facing this disadvantage of digital, cheaper options that were telling time just as well. He went back to his basic goods and he realized it was not about telling time, it was about the fact that watches have a lot of meaning, a lot of tradition. Its something that people pass down from generation to generation.

How long did it take to go from identifying a disadvantage to reclaiming their market share?

It was over the course of decades. Whats really key here is that a lot of times when were trying to flip those stereotypes in our favor, or trying to position ourselves, we think that its a once and for all thing, but its not just like flipping a switch.

You have to continue to guide the fact that watches are stylish, have deep meaning, have this tradition of advanced engineering that distinguishes their products against competitors like smartphones or digital watches that help you tell time. The guiding process continues.

Incongruity was a word that came up a lot in your writing. Why is it important to understand incongruity?

Thats your signal that something has gone awry, or that people arent seeing you in the way that you authentically are, or that youre like a watch company that is about to be outdated and overtaken by another company. The incongruity is when factors dont add up, and its a window into understanding the gaps in value. And theres a lot of really amazing, disruptive and very innovative things that come out of obstacles and incongruity.

Whats an example of a company missing the incongruity?

The Juicero company was trying to sell app-enabled juicers for $699. You had to buy special packs of vegetables and fruits, but it turned out you got the same results just squeezing the packs with your hands. And people asked, why do we need a machine that costs $699 to squeeze fresh juice when you can squeeze it with your hand?

There was something that was off around the story that the company was telling, which was that every household in America is going to want one of these, look at our potential market size. The investors had the same outlook, behaviors and background, and were very motivated by being able to press a button on their smartphone from bed and have fresh squeezed juice immediately. Outside of that group, the market opportunity just wasnt there.

You talked about following worth, rather than following money. What do you mean?

A lot of hard data is actually not that hard. Its hopes and dreams and guesses. Even though our financial projections are in numbers, theres a very real possibility that it can never go that way, that were not going to achieve that hockey stick growth. So when we think about the worth of something, we should ask: What are we trying to achieve? What are the real milestones? How far are we from those milestones? Whats the distance between where we are and what were trying to achieve? Whats the distance between where we are as an individual, and what we think were worth, and what other people think were worth? That gives us a much richer picture than a definitive sort of analytical hard number.

Is that a difficult concept to understand if youve been trained to analyze things in a more empirical way?

We have these false dichotomies: If youre logical, then youre not emotional. If youre emotional, youre not logical. And when we talk about gut feel and intuition, well think, Thats emotional, its subconscious, its biased.

But in fact, like gut feeling, intuition is something thats really emotional and cognitive. Its based on our experiences and our patterns and pattern matching. And even though we cant necessarily put our finger on it, its something thats not just emotional. It incorporates things that have been rational and have been a part of what weve considered and been very thoughtful about in the past as well. The more that were able to hone that intuition, and hone the way we think about worth, the better off were going to be.Youve mentioned delight. Why is it so important?

Delight is a key ingredient in giving yourself the opportunity to show how you enrich and provide value. The better off you know yourself, the more youre able to give your unique personal flavor to the things youre working on.

Remember the first time that you ever rode in an Uber? Forget all the other stuff that happened with Uber subsequently. The first time you rode in an Uber, theres this simultaneous sense of oh my gosh, this is weird. This is cool. This is scary. Im in a strangers car. It was like all of these feelings where the emotions and the rationality were intersecting.

Are younger people better at finding ways to pivot and delight than older people?

We tend to think that they would be, but theyre not.

One of the things thats really interesting in terms of the generational piece, is that were in this ethos where parents are trying really hard to give their kids an advantage. Were seeing things like Lori Loughlin and Felicity Huffman who are buying their kids way into college. Even in a more benign way, we see parents who are paying for extra tutors for their kids, getting them private coaches and that sort of thing. Ive found that parents who teach their kids how to create their own advantage, and gain their own advantage, those kids do much better because it is so situational. Those kids are able to go into situations and think, I know how to delight this person. They intuitively get it.

Has the perception of your work changed among your academic colleagues?

When I first started studying this, a lot of the literature and theory was around disadvantage and inequality and meritocracy in organizations and in entrepreneurship. And then a couple of years ago, I was just getting so many questions like, We see women are only getting 2 percent of venture capital financing even though they represent more than 50 percent of the firms being started. What can we do about this? What strategies can we try out?

I hope that Im still going to continue to be seen as somebody who really values the research and the research-backed rigorous findings, as well as what we can do about this. A lot of times it is one or the other: If youre practical, then youre not into rigorous research, and if youre into rigorous research, you cant be practical. Im really trying to marry the two.

Do you test your theories out on your family?

My daughter has always loved princesses. She kept insisting that she wanted books about them. My husband and I said no, because we want her to be more than a princess. We decided to tell her these delightful stories about a princess who was also an engineer and a princess who was also a chemist. These were improvised, but this is delight at its best in my personal life. Now my daughter wants to be a chemist and a princess.

Inspiration and advice for female leaders, founders and investors.

Frequency: Bi-Monthly

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Time to end the Blame Game – NWAOnline

Wednesday, January 29th, 2020

As Jesus went along, he saw a man blind from his birth. And his disciples asked him, "Rabbi, who sinned, this man or his parents, that he was born blind?" John 9:1-2

In life, some things are useful and others aren't. Blaming one's circumstances, one's birth right, one's parents, one's environment, for what kind of work we do or what kinds of faults we have is astonishingly useless. It is useless, misleading and harmful because it takes a person in a direction where there is almost no help for them -- almost no way for them to claim the inner power and the freedom that God has built into their very souls.

Another thing that is often equally useless -- equally misleading and equally harmful -- is trying to determine who is to blame for another person's misfortune. How often we have seen someone on the news -- or perhaps even a neighbor -- enduring one hardship after another and then heard others talking about the situation and saying things like: "Well, it is very unfortunate, but if the family only knew how to budget better they wouldn't be in that mess."

Or "It's sad, but what can they expect, they never look after themselves properly -- and they certainly don't take care of each other."

Or "They never had a chance - their parents were just the same."

Assigning blame for one's own misfortune (or for the misfortune of others) is virtually a national sport.

Who sinned? Who is at fault? What caused the problem? These can be good questions. Diagnosis is a very important thing -- as anyone who has gone to a doctor knows. But diagnosis by itself accomplishes nothing. It is what we do afterward that matters -- what we do afterward, and, just as importantly, what we do during diagnosis and what we do even before diagnosis is attempted. It is almost like seeing a person with a flat tire and saying, "Yep, that tire's flat!" and then walking away.

Today we are surrounded by people who live in worlds of blame and bitterness. In the end, the disciples' question about the man born blind is answered in how Jesus responded to that man and what he did as he defended Jesus as the source of his healing -- and then confessed Jesus as his Lord and worshipped him. Why, was he born blind?

"That the works of God might be made manifest in him," is Jesus' response.

This week this world can be full of the news of senseless tragedies: Fault and blame can easily be assigned -- but that is not what is needed. There is blame. There is blindness. And there is blessing. The only thing that can hold us back from experiencing the healing power of God in our lives is our own attachment to blame and our fondness for bitterness.

Time to end the blame game.

Editor's note: The Rev. Dr. Scott Stewart is the pastor of Pea Ridge United Methodist Church and Brightwater Methodist Church. The opinions expressed are those of the writer. He can be contacted at revjstewart@gmail.com or 479-659-9519.

Print Headline: Time to end the Blame Game The "Pit" The "Pit"The "Pit"The "Pit"The "Pit"

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Opening the Montreux Convention to debate is an act of strategic blindness – United World International

Tuesday, January 28th, 2020

Some experts have been saying that the Istanbul Canal will open the Montreux Convention up to debate, despite the governments assurance that the Istanbul Canal and the 1936 agreement regarding Turkeys ownership of the Turkish Straits are independent of each other. Retired Admiral Mustafa Ozbey has evaluated the Istanbul Canals correlation to the Montreux convention, and offered his opinions about how the Canal might affect it.

Ozbey believes that the Montreux agreement has already been opened up to debate by President Erdogan himself, adding that while Turkeys west, south and east are already in conflict and at risk, it is an act of strategic blindness to open the Black Sea to debate over the Istanbul Canal.

The Istanbul Canal has already debated in the context of its damage to the environment, the ecological differences between the Black Sea and the Sea of Marmara, the route which the Canal will be built, security concerns and more. The biggest controversy around the Canal, however, is its correlation with the Montreux Straits Convention.

Ozbey suggests that there is a lot of disinformation spreading about the relationship between the Istanbul Canal and the Montreux Convention, and even worse, that this disinformation has been crafted intentionally by those who oppose the Canal. If you notice, the supporters of the Canal are avoiding the Montreux debate as much as possible, whereas we are highlighting it specifically as the main issue. However, we are debating it in the wrong way, making it difficult to understand, Ozbey said.

Ozbey stressed the importance of making the Canal-Montreux Convention correlation simple, understandable and clear, and has evaluated the relationship with anecdotes:

1. The Montreux Convention Regarding the Regime of the Turkish Straits, is one of the most important international conventions of the 20th century.

2. The Convention ensured that all the powers of the Straits Commission (established alongside the Treaty of Lausanne to regulate the transit of ships and our sovereign rights for the Turkish Straits Region) be given to Turkey.

3. The Conventions verdicts include sovereign rights for Turkey far beyond the powers of the previous commission. The Convention also granted Turkey management of one of the most critical passageways in the world.

PxFuel

4. Turkey has fulfilled its authority and responsibility with such success during the Second World War and the Cold War eras, that an unwritten immunity has been established for the convention.

5. In light of the Conventions fair and successful implementation, the signatories did not even request any repeal/amendment, despite that the terms of the Convention expired 20 years ago.

6. With the statutes that were established in 1994 regulating the transit of merchant ships, Turkey clarified the principle of freedom of passage. Turkey has used the arrangement to pressure the IMO to adopt new safety precautions through the Turkish Straits. With the other improvements it has implemented over time, Turkey has used its authority to improve both the navigation of transitions and the overall safety of the Turkish Straits.

7. Turkey should use its right and authority to make crossing through the straits safer without having to open a canal that will be extremely expensive and potentially cause an environmental disaster.

8. Experts believe that the canal could actually make crossings more dangerous.

9. The free of crossings hypothesis, one of the justifications for the Canal, is also based on a misleading argument. Strait crossings are conducted in accordance with the verdicts of the convention. Increasing the income from crossings is also possible by staying within the Montreux Convention. The Convention is backed by the Gold Standard as a result of using the French Franc as its payment currency. In 1981, Turkey experienced a huge loss of revenue as a result of using the US Dollar as a currency instead of the Franc. By correcting this mistake, Turkey will be able to increase its income significantly.

10. Charging a fee for Canal crossings is unlikely. This is essentially an imaginary justification for the construction of the Canal. Even if the Montreux Convention is repealed, it will not be possible for merchant ships to be diverted to another route.

11. As discussed earlier, the security and income of transit will not actually increase with the opening of the Canal.

By Randam Own work. Adjusted from Kanal stanbul.svg, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=84903496

12. In regard to warships using the Strait: although there have been some attempts to violate the agreement, countries have been found to be complying to the verdicts of the Convention. However, it is well known that the United States is not happy with the restrictions on the Black Sea and is striving to change things.

In this context, if the Canal is opened, technical debates such as those around the Dardanelles Canal, as well as debates over whether warships should be allowed to pass through the Canal or not, could prove dangerous.

13. Erdogan has made his first major mistake around the issue by inviting NATO to the Black Sea after the downing of the Russian jet in 2016. NATO exercises grew more frequent as a result.

14. Even if Turkey gives up on the idea of the Canal, the Convention has already been opened to debate by Erdogan. Although the United States is not even a party to this Convention, we can expect that it is preparing amendments for the passage of warships and its presence in the Black Sea, via Romania and/or Bulgaria.

15. While Turkeys west, south and east are already in conflict and at risk, it is an act of strategic blindness to open the Black Sea to debate over the Istanbul Canal.

16. Russia is observing these debates very quietly and with diplomatic courtesy for the time being. However, Russia has stated that it considers the Montreux Convention, sacred. Thus, it will not actively involve itself in the debate until the last moment. Moscow will, however, monitor the formation of any new fault lines between the US and Turkey. It should also be kept in mind that if Russia sees concrete cooperation between the United States and Turkey, such as that which would inevitably result from violating the Montreux Convention, it will use all the cards it has to counter it.

Turkey should immediately end the fabricated Canal Istanbul disgrace, and return to its former path.

-

Mustafa Ozbey started his career in 1965 as a naval officer Following his graduation from Turkish Naval Academy

Ozbey actively participated in the Cyprus Peace Operation in 1974 and Kardak Crisis.

In 1996, Ozbey served in various different warships as a department head, executive and commanding officer

He has also served as a destroyer division commodore and flag officer for various combatant squadrons .

Most recently, he was a chief of staff at Turkish Fleet HQ as rear admiral.

Ozbey has participated in advanced training programs both domestically and abroad, and worked in NATO Headquarters in Brussels between 1984 and 1987.

He retired in 2001 with the rank of Rear Admiral at his own request.

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How punk rock helped one woman find power in her blindness – CBC.ca

Tuesday, January 28th, 2020

"You must sing like an angel," a woman once said to Leona Godin when she was about to go onstage with her white cane.

The woman clearly had not seen me perform, Godin thought.

The Avant-Accordion Brain-Smash performance she prepared for the show was anything but angelic. It was loud and brash. Dark and complex.

From an early age, Godin embraced punk rock because it reveled in the messiness and complications of life.

"Fighting against the idea of the monolith of blindness [with punk rock] is kind of my raison d'tre these days," she told Tapestry host Mary Hynes in an interview.

Like the woman Godin encountered backstage, many people jump to the assumption that a blind singer must sound angelic. They think of artists like Andrea Bocelli, whom Celine Dion praised as having the voice of God and Canadian record producer David Foster has described as having the most beautiful voice in the world.

But Godin, who was diagnosed with degenerative retinal disease as a child, wants us to ditch that stereotype.

Leona Godin singing and playing drums in her band Gutter & Spine's "Sludge" video (2007)

"There are just as many ways of being blind as there are of being sighted," she pointed out. "There's all kinds of permutations for what it is to be a sighted person, and I want that for blind people too."

Godin, who's also a writer, describes her own music as being focused on ideas. It's not beautiful by any means "there's a lot of chanting, bellowing and screaming," and it takes inspiration from dark themes she encountered in literature.

Godin's passion for punk rock began at around the same time when she started losing her eyesight as a child. In the early '80s, less was known about degenerative retinal disease than today. So when her mother took her to see eye doctors, none of them could figure out what was going on, and instead blamed her for her condition.

The head of ophthalmology at the Letterman Army Hospital in the now-decommissioned Presidio of San Francisco scolded her mother: "maybe she can't see because you've been taking her to so many eye doctors." Other doctors told Godin that her eyes are growing too fast for her body, she recalled.

"It was things like that that primed me for a mistrust of authority, which I think is a very good place to be when you start to hear punk rock because it's all about that," said Godin.

As Godin's vision continued to deteriorate, she struggled to make out words and faces. By the time she was 15 years old, she could no longer read books. Godin began experimenting with LSD and delved deeper into the world of punk rock to help her cope.

The drugs, the punk music and the lashing out were Godin's way of venting her frustration at going blind and not being able to do anything about it, she shared.

Getting into trouble and defying authority helped Godin shatter the pity that people felt for her, which she despised.

Punk rock in the '80s was new and edgy, anti-establishment and raw. It also came with a kind of cheap, do-it-yourself, anti-commercial aesthetic that some may find brutal, but Godin found beautiful.

"I remember wearing these fish bobbins as jewelry. That was very attractive to me."

There was a boy in her high school who had bright green hair, which was unusual at the time, and Godin was enamoured with him.

"He was so attractive and I think maybe part of the attraction was simply he was so noticeable," Godin recalled. "There's some part of me that wonders how much was it just a natural tendency to want to be a rebel as a kid, and how much of it was the eye disease and me just liking things that were extremely visually striking because I couldn't really notice subtlety."

Godin said her life-long obsession with things that are ugly and that push the limits of what's acceptable likely originated from her inability to fit in.

"A lot of people with disabilities want very badly to fit in, to try and be normal," said Godin. "But I realized at a certain point that I was never going to be normal. So you can either bang your head against the wall, or embrace the abnormality of seeing things differently or not seeing what other people see."

Godin eventually took her love of punk rock music to the stage as a performer. But these days, she's working on a book focused on what she calls a "cacophony of blind voices."

"What I mean by that is there are as many ways of being blind as there are of being sighted, and I want all those possibilities to exist and clash, because that's what being punk rock is about," she explained.

For Godin, punk is about more than loud music or a brutalist aesthetic; punk is an ethos. She said embracing the spirit of punk rock means reaching beyond stereotypes when we encounter someone who's different from us.

"It's realizing that what we don't understand is not necessarily simple or easy to put into a box, and it's okay to not understand it, but we shouldn't dismiss it," said Godin.

"The most punk rock spirit is really just tearing it up and making the whole story look a lot messier, a lot more raggedy. So open your ears to the cacophony of blind voices instead of the stereotypes we're used to, and let's hear it for the messiness."

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Blind Foundation for India Announces $5 Million in Funds Raised to Treat Blindness – India West

Tuesday, January 28th, 2020

The Blind Foundation for India in a Jan. 12 news release announced it has raised $5 million.

The foundation was established in 1989 with a mission to prevent and cure blindness, and educate and rehabilitate permanently blind people in India.

There are over 15 million blind people in India which translates to one out of every three blinds in the world, the release from BFIs Indian American president Dr. Manu Vora said.

There is a power of prevention, such as $1 of Vitamin A drops administered from age 4-6, which prevents the child from going blind. That child getting education has a potential to earn $100,000 during his or her lifetime $1 investment leading to $100,000 benefit of exponential power, it said.

Additionally, in India it only costs $20 for a cataract operation as compared to $4,000 in the U.S.

The funds raised will be used to examine the eyesight of over 1 million adults. So far, BFI has conducted over 200,000 free cataract operations, donated 131 medical mobile vans to transport doctors and patients, and distributed over 10,000 Braille kits to blind children for their education. The major BFI focus is on prevention of Blindness through Child Sight Projects. Over 1 million school childrens eyesight has been examined and given free glasses, eye drops, Vitamin A, and in some cases, cataract operations, it said.

With Rotary International Matching Grants, BFI has completed 14 projects worth $500,000. About 75 percent of BFI funding is provided to various Ramakrishna Mission Centers throughout India for blind welfare work.

In 2012 with major BFI funding, OPD Hall and Consulting Rooms was established at the Vivekananda Eye Care Center at Shri Ramakrishna Ashrama in Rajkot, Gujarat.

Currently, they treat daily 500 OPD eyecare patients with 25-30 cataract operations per day performed all year round, the release said. In 2019, a new Cornea Transplant Center was added at SRA. In 2014, two Medical Mobile Vans were donated to the Ramakrishna Mission Home of Service, Varanasi, for regular outreach to rural communities surrounding Varanasi area, the release added.

In June 2004, BFI received a Daily Point of Light Award by the Points of Light Foundation. The foundation has also received Letter of Commendations from presidents Bill Clinton, George H. W. Bush, George W. Bush and Barack Obama. In meetings with the vice president of India, BFI updates were shared in 2001 and in 2004. In 2011, 30 BFI volunteers received a Volunteer Service Award from Obama.

More information about the foundation can be found by visiting http://www.blindfoundation.org.

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Blind Foundation for India Announces $5 Million in Funds Raised to Treat Blindness - India West

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Australian of the Year calls for sugar tax to fight diabetes-caused blindness – The Age

Tuesday, January 28th, 2020

"Sugar is cheap and ubiquitous, so it's readily accessible to everyone. You walk into a service station and there's a counter of lollies as you walk in," he said.

Dr Muecke, 56, was named Australian of the Year 2020 at a glittering awards ceremony in Canberra on Saturday night, in recognition of his work preventing blindness in Australia and the developing world.

The Sight For All co-founder had been nominated for the honour alongside orthopaedic surgeon Munjed Al Muderis, the NSW Australian of the year who is lobbying for action on climate change, singer-songwriter Archie Roach (Victoria), Jess Melbourne-Thomas (Tasmania), Rachel Downie (Queensland), Annie Fogarty (WA), Katrina Fanning (ACT) and Geoffrey Thompson (NT).

"Blindness is just one of many complications of diabetes and, as an eye surgeon, I see the end stages of the disease," Dr Muecke said.

"I think we need to take sweet products away from checkout counters, particularly when they're discounted," he said.

"We've got to make them less accessible to the public."

National Australia Day Council chair Danielle Roche said Dr Mueckes "passionate and selfless commitment to preventing blindness" was "changing lives".

Dr Muecke said he also wanted to encourage people with diabetes to get their eyes checked.

"The problem is, more than half the people with this disease are not having their regular sight-saving eye checks," he said.

"They're coming in too late, sometimes too late for treatment, too late to reverse the vision loss."

Prime Minister Scott Morrison paid tribute to the volunteer firefighters battling bushfires in his opening remarks at the Australian of the Year awards, saying the thousands of men and women were "reminding us about what it means to be a citizen of this great nation".

"They - like the nominees here tonight - are demonstrating to us that our national story is one of great achievement - but also of pain, of effort, sweat," Mr Morrison said.

"Through this long summer, we have seen the unquenchable spirit of Australians. Australians rallying to each other, be they family, friends, or indeed strangers."

Dana is health and industrial relations reporter for The Sydney Morning Herald and The Age.

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Australian of the Year calls for sugar tax to fight diabetes-caused blindness - The Age

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Studies target unilateral gene therapy injection – Ophthalmology Times

Tuesday, January 28th, 2020

Abstract / Synopsis:

Research is finding key patient benefits to gene therapy as a promising treatment strategy for Leber's hereditary optic neuropathy (LHON).

This article was reviewed by Patrick Yu-Wai-Man, FRCOphth, FRCPath, BMedSci, MBBS, PhD

Data from two clinical studies of Lebers hereditary optic neuropathy (LHON) showed substantial visual improvements in patients with both disease durations of less than six months and between six months and one year. The improvements resulted from a unilateral injection of a gene therapy vector (GS010) and remarkably, the viral vector seemed to be carried over to the untreated eye.

The mechanism of action for these unexpected results need to be clarified with further experimental work.

Related: Research targets precision dosing for gene, cell therapy

LHON is the most common cause of mitochondrial blindness with a minimal prevalence of one in 30,000 individuals in the population. It causes blindness mostly in young adult men with a peak age of onset in the third decade of life. It is invariably a bilateral disorder in which the fellow eye becomes affected within three to six months after disease onset in the first eye.

Both eyes are affected simultaneously in about 25% of patients, according to Patrick Yu-Wai-Man, FRCOphth, FRCPath, BMedSci, MBBS, PhD, an academic neuro-ophthalmologist with faculty positions at the University of Cambridge, Moorfields Eye Hospital, and the UCL Institute of Ophthalmology, in the UK.

Three primary mutations within the mitochondrial genome cause about 90% of cases worldwide, namely, m.3460G>A, m.11778G>A and m.14484T>C, with m.11778G>A being the most common mutation by far, accounting for over 70% of those affected with LHON. Unfortunately, most affected patients remain legally blind with vision worse than 1.3 logarithm of the minimum angle of resolution (logMAR) or 3/60 in Snellen equivalent.

Given the poor prognosis, there is an urgent clinical need to identify effective treatments for this blinding optic nerve disease.

Related: LHON gene therapy: Deciphering phase III data

TreatmentGene therapy is obviously a very attractive treatment option, because the underlying pathophysiology is due to insufficient amount of the wild-type protein, Dr. Yu-Wai-Man said. Therefore, if the defective gene is replaced, we should be able to rescue the retinal ganglion cells, preserving function and improving the visual prognosis.

He described the principles of allotopic gene expression that involves inserting the mitochondrial gene of interest, in this case MTND4, into the nuclear genome with a modified viral vector. The wild-type protein produced has a specific mitochondrial targeting sequence that directs it to be imported into the mitochondrial compartment.

The use of an intravitreal injection is a big advantage for this treatment approach as it is a relatively straightforward procedure that provides direct access to the inner retina. Previous preclinical work indicates that allotopic expression is able to rescue the retinal ganglion cells from the deleterious effects of the m.11778G>A mutation.

Related: Gene therapy offering hope for retinal, corneal patients

Continued here:
Studies target unilateral gene therapy injection - Ophthalmology Times

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