header logo image


Page 71«..1020..70717273..»

Archive for the ‘Arthritis’ Category

Gene Therapy for Rheumatoid Arthritis gets Approval to Start … – Labiotech.eu (blog)

Saturday, February 18th, 2017

Arthrogen will start a Phase Ib trial for a gene therapy aiming to treat rheumatoid arthritis with a single injection and reduce costs for patients.

Arthrogen,based in Amsterdam, is developing local gene therapies for inflammatory diseases. The biotech company has now announced it has received approval to start a Phase Ib trial with its lead candidate, ART-I02, in patients with rheumatoid arthritis who still suffer from inflamed joints despitemultiple treatments.

The clinical trial will be conducted by the Centre for Human Drug Research (CHDR) in Leiden, with collaboration from other University Medical Centers in the Netherlands. Patients will start to be recruited in the first quarter of this year and results are expected by the end of 2018.

ART-I02 consists of a recombinant adeno-associatedviral vector (rAAV) genetically engineered to encode the human interferon (hIFN-) protein, which has anti-inflammatory activity.By including an inflammation-inducible promoter in the genetic construct, the gene is only expressed when the patient suffers flares of acute pain and inflammation.

Founded in 2005 as a joint venture between the Dubai Bone & Joint Center (DBAJ) in the United Arab Emirates and the Academic Medical Center (AMC) in Amsterdam, Arthrogen has managed to raise almost 15M so far to support its pipeline for inflammatory disease.

One of the advantages of ART-I02 is that its delivered locallyin the rheumatic joint, only affecting the target area to minimize side effects. In addition, gene therapy offers a long-lasting treatment with a single injection, which can significantly reduce costs for patients in the long term. However, Arthrogen will have to be careful to not follow the steps of its neighboruniQure, whose firstcommercial gene therapy was a failure because of pricing issues.

Rheumatoid arthritis is a big market, expected to generate 32.5B ($34.6B) by 2020. The space is crowded, but by then blockbusters like top-seller Humira will no longer be protected by patents in both the US and Europe, leading the way for biosimilars and other options affordable in the long term such as gene therapy.

Images byMidas Anim; Tefi /Shutterstock

Original post:
Gene Therapy for Rheumatoid Arthritis gets Approval to Start ... - Labiotech.eu (blog)

Read More...

Jordan youth walks to cure juvenile arthritis – SW News Media

Friday, February 17th, 2017

Jordans Jack Friedges is putting one foot in front of the other to help find a cure for arthritis.

Friedges will be participating in the annual Walk to Cure Juvenile Arthritis event at the Mall of America on Saturday, March 4 at 9 a.m. The event features a three-mile and one-mile course.

Friedges has also been named the Young Adult Honoree for this years event.

The cause is personal for Friedges, who was diagnosed with juvenile idiopathic arthritis (JIA) in 2014. Friedges was able to keep his arthritis under control with the help of medication, and he continues to be a three-sport athlete at Jordan High School in football, basketball and baseball.

I joined the Arthritis Foundations Walk to Cure Arthritis to help the more than 50 million Americans and 300,000 children with arthritis live better today and to keep the Arthritis Foundations promise of finding a cure for tomorrow, Friedges wrote on his donation page.

Your support provides people with arthritis life-changing resources and information to manage their disease and improves access to the critical medications they need to live full, healthy lives. The impact of your donation doesnt stop today, it also helps fund cutting-edge research to identify better treatments and a cure, Friedges added.

Friedges has set a goal of raising $5,000 for the event. As of Monday, he had raised $1,515 through his fundraising site, which can be found at http://bit.ly/2lIhosf

The Jordan Basketball Association will be hosting a fundraiser to support Friedges during the Hubmen and Jaguars basketball games on Tuesday, Feb. 21.

The girls game against Waseca will start at 6 p.m., and the boys will play Holy Family at 7:45 p.m.

Find a Cure for Juvenile Arthritis Jacks Journey bracelets will be on sale for $2, and all proceeds from the half court toss at both games will benefit the Juvenile Arthritis Foundation on Friedges behalf.

View original post here:
Jordan youth walks to cure juvenile arthritis - SW News Media

Read More...

Potential therapies for chikungunya arthritis – Nature.com

Thursday, February 16th, 2017
Potential therapies for chikungunya arthritis
Nature.com
Targeting T cells is emerging as a promising strategy for the treatment of chikungunya arthritis. Two independent studies published in Science Translational Medicine demonstrated amelioration of disease when targeting pathogenic CD4+ T cells in mice ...

The rest is here:
Potential therapies for chikungunya arthritis - Nature.com

Read More...

New player in RA pathogenesis brought to light – Nature.com

Thursday, February 16th, 2017

Nature.com
New player in RA pathogenesis brought to light
Nature.com
A novel subset of T cells is responsible for driving autoantibody production by B cells in the synovium of patients with rheumatoid arthritis (RA), according to new research published in Nature. These cells, dubbed T 'peripheral helper' cells, are ...

Read the original here:
New player in RA pathogenesis brought to light - Nature.com

Read More...

Putting Maud and arthritis into the frame | Irish Examiner – Irish Examiner

Wednesday, February 15th, 2017

After opening the Dublin Film Festival, director Aisling Walsh hopes to bring her story of an artist battling arthritis to the world, writes Esther McCarthy.

Ethan Hawke and Sally Hawkins in Maudie, the true story of artist Maud Lewis, directed by Irish filmmaker Aisling Walsh, left.

She was the low-key, quirky artist whose paintings, sublime in their simplicity, made her beloved in her native Canada.

Now an Irish filmmaker is hopeful that she can help make the work of Maud Lewis celebrated throughout the world.

Lewis, who sold painted cards out of her remote home in Nova Scotia, defied crippling rheumatoid arthritis, which she developed in childhood and suffered from throughout her life, to become one of Canadas most loved folk artists.

Irish director Aisling Walsh is bringing Lewiss story to the big screen in an intimate drama, Maudie, starring Sally Hawkins and Ethan Hawke, that will open this years Audi Dublin International Film Festival. The film also focuses on Mauds difficult marriage to her husband, Everett.

ADIFF, which will feature scores of anticipated Irish and international features and shorts, and Walsh, for one, is looking forward to bringing her film home for the opening night.

Its a couple of years since I screened a film in Ireland, so its rather special for me. Im looking forward to it very much, said the London-based filmmaker, whose credits include acclaimed Irish film Song For a Raggy Boy and the award-winning TV series Fingersmith and Room at the Top.

Its interesting, you spend so long making a film, a long time putting it together in the cutting room and trying to get it up to its flying best as I call it, then you try to bring it out into the world.

The response has been kind of universal. Its amazing how people respond to it. They laugh, they cry, they go on that journey. Thats really satisfying.

Walsh hopes that the film will help bring Mauds story and work to a wider audience.

Shes well known in Nova Scotia where shes from, in Toronto, Vancouver and in America as well because people travelled and holidayed quite a lot in that part of the world, would have stopped outside the house and bought her work.

But otherwise, like a lot of women artists she isnt terribly recognised. Its amazing that shes not. Its nice that this will hopefully make her a little more well known in the world.

Walsh, whod trained as a painter before forging a career in film, had been interested in making a film about an artist for almost a decade and was watching out for the right project.

When Sherry Whites script landed on her desk, she was hooked. Id looked at making a film about a painter, there were one or two stories I was interested in. I did know her work, Id seen these pictures.

Then I thought of Sally and thought it could be a really good opportunity for us to work together again, wed been trying to find something to do together (since collaborating on the mini-series Fingersmith).

This just seemed to be right. And that story I was just fascinated by the portrait of that marriage, that love story. I thought that I could bring something to it, that if youre lucky could be kind of magical.

As well as her art, the film focuses on Mauds complicated marriage to Everett Lewis, a temperamental man with whom she had a loving but often-fraught relationship.

There are dark details within their union, and in the wrong hands this tale of an imperfect romance could have rung less true. A lot of it is two people in a room, in a landscape together. Would I have done it ten years ago? No, Id probably have run for the hills. That (the relationship) is quite complex in its own way because youve got nowhere to hide. It just really spoke to me, so much that I thought I really want to make this film.

Maud had severe arthritis that impacted greatly on her movement, but Walsh and Hawkins never characterise this in a way that feels mawkish or manipulative.

People who have disabilities have disabilities, says Walsh. They live with them. They dont think of them as disabilities. Thats what youve got in life and you get on with it. Apart from the pain she had, which apparently got quite bad in later life, that was how she was and who she was.

Its really important that you dont think about it, but that its there, thats who Maud is. Shes lived with it all her life. I thought that was an interesting way to play it, and Sally really wanted to do that too.

Though Walsh has lived in London since moving to the city to study three decades ago, she still considers Dublin to be home and spent almost six months here last year, largely working on post-production on the film.

I came here originally for three years as a student and never thought Id be here this long. I always consider Dublin home, she observes.

If youve lived in London like I have for thirty years, you get used to that scale and size and there are a lot of things there that I love.

Though she considers the recent Brexit vote a shame she doesnt see herself leaving London permanently. Theres a point where you realise that its going to happen. Its interesting, I know people who voted to come out and people who desperately wanted to stay.

"Maybe they have to be out for a while to remember why it would have been good to stay. I think its a shame because theyre a very strong voice in Europe.

The cast is almost entirely made up of actors with intellectual disabilities.

Irish Examiner Ltd. All rights reserved

Read more:
Putting Maud and arthritis into the frame | Irish Examiner - Irish Examiner

Read More...

Walsall Manor Hospital-based arthritis unit set for the axe – expressandstar.com

Wednesday, February 15th, 2017

A service helping patients with arthritis and joint pain looks set to be axed from Walsall Manor Hospital because it is unsustainable, according to a report.

The boroughs Rheumatology service, which is run by Walsall Healthcare NHS Trust, may close due to its size with plans being drawn up to have a service covering the whole of the Black Country.

Health bosses behind the Black Countrys Strategic Transformation Plan (STP), have said it is difficult to recruit and keep consultant rheumatologists for the service.

It is currently made up of two consultants and clinical nurse specialists. Arthritis and back pain are among the conditions treated.

The STP states: We already have well advanced discussions regarding the Rheumatology service, which is unsustainable in Walsall due to the small size of the service making recruitment and retention of consultant rheumatologists really difficult.

As a result of our network approach, we have collectively made available short-term resources to sustain the service, and have been successful in recruiting three consultants who will join later this year.

This will lead to a reduction in locum spend in the second half of the year.

Royal Wolverhampton NHS Trust already provides rheumatology services for a large part of Staffordshire as well as Wolverhampton.

Councillor Ian Robertson, Walsall Councils health boss, said he thought the change to a Black Country-led service makes sense.

He added: I think when you have a specialist service it is easier to recruit if you can tell them you will be looking after a series of hospitals rather than just one.

"It makes sense to have a large group sharing some specialist services to save money.

The service in Walsall is offered Monday to Friday at the Manor and the Outpatient and Day Case Centre.

It offers specialist clinics, including early arthritis, and a range of treatments, including infusions and injections.

The rheumatology team has strong links with primary care providers and services such as the falls prevention programme based at Dartmouth House in the town.

The team also provides an expert patient programme, which can be accessed by people with long-term conditions, and works alongside voluntary services.

See more here:
Walsall Manor Hospital-based arthritis unit set for the axe - expressandstar.com

Read More...

How Does Psoriatic Arthritis Affect Diabetes Risk? – Endocrinology Advisor

Wednesday, February 15th, 2017

Endocrinology Advisor
How Does Psoriatic Arthritis Affect Diabetes Risk?
Endocrinology Advisor
The prevalence of diabetes is higher in patients with psoriatic arthritis (PsA), with greater PsA activity correlating with a higher risk of developing the disease, according to recent research published in The Journal of Rheumatology. Psoriatic ...

Follow this link:
How Does Psoriatic Arthritis Affect Diabetes Risk? - Endocrinology Advisor

Read More...

Psoriasis has affected absolutely everything in my life – Irish Times

Wednesday, February 15th, 2017

Marion Morrissey from Co Limerick was diagnosed with psoriasis at 15.

Living with a chronic skin condition can be very difficult as although it may not be life threatening, treatment can be all-consuming and the anxiety caused by such a visible disorder can take its toll.

Up to 140,000 people in Ireland suffer from psoriasis, an auto-immune disorder which causes the skin to reproduce at a rapid pace resulting in itchy, painful scales all over the body, including the scalp and nails.

And if this discomfort wasnt enough, 40,000 will go on to develop psoriatic arthritis which affects the back and joints causing severe pain and immobility.

This month, Arthritis Ireland has launched a campaign entitled More than Skin Deep, which provides expert information on the condition and advice for sufferers.

There is a lot of research going on in Ireland into psoriatic arthritis and its causes, says consultant rheumatologist Prof David Kane.

These are mainly looking at the genes that cause the condition in families and using ultrasound imaging and synovial tissue biopsy of the joints to study patients who have the disease in order to find new targets for treatments.

For immediate pain relief there are a range of painkillers but these do not deal with the underlying inflammation which will ultimately lead to permanent joint damage.

But fortunately there are now a lot of specific treatment options for psoriatic arthritis that will reverse the joint inflammation, reduce pain and prevent joint damage.

Marion Morrissey from Co Limerick knows only too well what it is like to have the condition as she has suffered with it since she was a teenager.

I was diagnosed with psoriasis at 15 so have lived with the condition for more years than I have lived without it and it has affected absolutely everything in my life, says the 39 year old.

My initial diagnosis was of a very dry flaky scalp at the hairdressers. I then went to my GP who diagnosed psoriasis. But that GP (and many others since), didnt have much time or empathy as psoriasis wasnt perceived to be serious as its not usually life threatening.

But my condition got progressively worse until I had almost 75 per cent body coverage. Then when I was 24 I got nail psoriasis which looks like a fungal infection there was no treatment for this but luckily, being female, I could paint my nails. Over the years I have tried every treatment available from conventional to alternative creams, lotions, ointments, sprays, moisturisers, shampoos and PUVA light treatment anything that offered even a glimmer of hope, but none really worked.

Morrissey, who is married with three children and runs her own healthcare training company, http://www.safeaid.ie, was dealt a further blow when the skin condition transferred to her joints.

I developed psoriatic arthritis aged 32 and became really worried about my quality of life, she admits. The pain and stiffness started in my fingers and toes it was really severe especially in the mornings, really affecting my ability to carry out normal daily activities.

My fingers and toes would be hot and throbbing and had a sausage-like appearance so this along with the stiffness and pain made many tasks difficult. Driving was affected as getting a grasp on the steering wheel and pressing on the pedals was hard due to the pain in my toes. Even brushing my daughters hair was a problem as I couldnt hold the brush and this really took its toll emotionally.

The pain and stiffness spread to her knees, ankles, elbows and neck until eventually Morrissey sought help. She was diagnosed with psoriatic arthritis and put on medication and while it took several different drugs to discover which would work best for her condition, her current medication is keeping the pain under control and for the first time in years, she is living life to the full.

I got my official diagnosis from a rheumatologist who gave me steroid injections in my fingers and toes, says Morrissey. But this only worked for a month or so before the symptoms came back. Then I was put on many different types of anti-inflammatory drugs which also just kept things at bay for a while before I got significantly worse.

The pain was so bad at one point that I had to set my alarm for 4am in order to take a cocktail of medication so I could function and get downstairs by 7am. With a new baby and two older children, this was incredibly difficult, particularly as I was also trying to keep my business going.

But 4 years ago I was started on a different drug and I havent looked back since. I have been given my life back and cannot even begin to compare it now to what it was before.

I am totally symptom-free and to date, havent experienced any side effects. I live a very full and busy life both at home and in work and I am very thankful.

My advice for anyone who has just been diagnosed with psoriasis or psoriatic arthritis is to be assertive and keep going until you find the right treatment as the results can be life changing.

Kane says lifestyle changes can also help ease the often crippling symptoms of this condition.

Medication is the cornerstone of treatment for psoriatic arthritis, he says. But patients can also help manage their condition by having a healthy diet, managing their weight to reduce the strain on their lower limb joints, exercising to keep joints and muscles healthy, managing stress levels and seeking help for anxiety and depression.

Anyone who is concerned they may have the condition should raise this with their GP or dermatologist both should be able to spot early signs of psoriatic arthritis.

For more information visit http://www.arthritisireland.ie

Read more:
Psoriasis has affected absolutely everything in my life - Irish Times

Read More...

Drug combo works against chikungunya arthritis in mice – Trinidad Guardian

Tuesday, February 14th, 2017
Drug combo works against chikungunya arthritis in mice
Trinidad Guardian
Combining a drug for rheumatoid arthritis with one that targets the chikungunya virus can eliminate the signs of chikungunya arthritis in mice in the disease's earliest stage, according to researchers at Washington University School of Medicine in St ...

Read more:
Drug combo works against chikungunya arthritis in mice - Trinidad Guardian

Read More...

Researchers develop new arthritis treatment – Bel Marra Health

Monday, February 13th, 2017

Home Anti-Aging Arthritis Researchers develop new arthritis treatment

Researchers from Washington University in St. Louis are developing a new treatment for arthritis that can ease symptoms and make existing medications more effective. Injuries such as a twisted ankle, broken hip, and torn knee cartilage can have long-term side effects including arthritis, joint degeneration, osteoarthritis, and inflammation that could result in chronic pain. The team, led by professor Lori Setton, have found that silk particles can aid in the delivery of existing medications to affected areas that are sometimes hard to reach.

To develop this new treatment, the researchers addressed the main cause of cellular breakdown, inflammation, and pain following an injuryan intracellular compound referred to as nuclear factor kappa B (NF-kB). They are currently working on a method that utilizes silk to deliver two NF-kB inhibiting molecules to the site of the original injury in order to prevent long-term joint damage.

Setton explained their method, stating Silk naturally doesnt interact with water, and, when you mix it with these molecules that also dont interact with water, they bind to each other very strongly. We believe these selective compounds are therapeutically effective, but weve never been able to get them to their target site. By delivering them with the silk, we hope to get large doses to the target site with low toxicity and to have them remain in that compartment for longer periods of time.

In initial trials, Setton and her team have shown that compounds are able to stay in the joint space approximately five times longer when they are delivered with silk microparticles than when they are delivered alone. This new delivery method will begin testing in animal models in the near future.

If this method proves to be effective in animal and human trials, it could provide a more efficient way of treating the cause of long-term joint damage and potentially prevent the development of musculoskeletal disorders such as osteoarthritis.

Related: Living with arthritis? Simple lifestyle and exercise tips to improve your joint health

Related Reading:

11 best essential oils for arthritis: Control arthritis and inflammation

Osteoarthritis pain in older adults can be managed with chair yoga

https://medicalxpress.com/news/2017-02-apill-team-arthritis-treatment-silk.html

See the rest here:
Researchers develop new arthritis treatment - Bel Marra Health

Read More...

New research links Crohn’s disease to arthritis – Bel Marra Health

Monday, February 13th, 2017

Home Colon And Digestive New research links Crohns disease to arthritis

New research published in Science Translational Medicine has revealed a bacterial link between Crohns disease and arthritis. Crohns is a form of inflammatory bowel disease, or IBD, that causes abdominal pain and diarrhea, and patients have also reported experiencing joint pain.

The immune system of patients with Crohns attacks the bowels and digestive system, but it can also target the musculoskeletal system and cause spondyloarthritis, resulting in spine and joint pain. This new research has found a link between the two conditions that may help explain why the immune system can turn its sights on the musculoskeletal system.

Researchers gathered fecal samples from patients with IBD and found that those with IBD and spondyloarthritis had a significant presence of E. coli bacteria in their samples. These samples, as well as mouse models, were used by the team to conclude that the E. coli bacteria was connected to the cells that help regulate inflammation in individuals with autoimmune disorders. Patients who had both Crohns disease and spondyloarthritis were found to have higher levels of these inflammation regulating cells, which are triggered by a protein known as IL-23.

These results have provided a target for potential treatments and medications, and with a better understanding of the inflammation caused by bacteria, scientists may be able to develop better treatment options to relieve the symptoms of Crohns and spondyloarthritis. They also open the door for the development of more personalized treatment regimens, as doctors may soon be able to address sources of inflammation specific to each patient.

Related Reading:

Crohns disease natural treatment with home remedies

Never ignore these types of stomach pain

http://news.weill.cornell.edu/news/2017/02/research-uncovers-bacteria-linking-crohn%E2%80%99s-disease-to-arthritis

Excerpt from:
New research links Crohn's disease to arthritis - Bel Marra Health

Read More...

Vital Signs: Treatment options can ease pain of hand and wrist arthritis – The Daily Progress

Monday, February 13th, 2017

Osteoarthritis of the hand and wrist is a relatively common condition that can lead to significant pain, stiffness and functional limitation. In some cases, arthritis can develop after a fracture or other trauma. However, most of the time it occurs as part of the aging process. Over time, the normal cartilage within the joint degenerates, thins and can wear away entirely, causing pain and inflammation.

Arthritis can occur in any of the joints of the hand and/or wrist, but the joint at the base of the thumb and the small joints of the fingers are most commonly affected. So, how do you know if you may be affected?

Patients with arthritis typically have pain and swelling in the affected joints. They also may notice that certain knuckles become more prominent as a result of osteophyte (bone spur) formation. Range of motion often becomes more limited. Many patients report difficulty with pinching and gripping activities, like opening jars or turning doorknobs or car keys.

Unfortunately, there is no good way to prevent hand and wrist arthritis. Its believed to be caused by a combination of genetics and just general wear and tear that occurs during life. If you do experience symptoms, however, seeing a doctor as soon as possible may allow for more treatment options.

Initial evaluation of the patient with arthritis usually will include a detailed history, including activities or treatments that worsen or improve symptoms. Physical exams can help determine which areas are most symptomatic, as well as assessing the motion and stability of the affected joints. Often, X-rays will be ordered to confirm the diagnosis and guide treatment.

For patients with earlier-stage disease and milder symptoms, conservative treatments such as ice or heat, rest or activity modification can be effective. Anti-inflammatory medications like ibuprofen (Motrin, Advil) or naproxen (Aleve) or pain relievers like acetaminophen (Tylenol) also can help with symptoms. For arthritis in certain locations like the joint at the base of the thumb splint usage or hand therapy may have a role. As symptoms become more severe, steroid injections into arthritic joints may provide short-term relief.

For patients with more advanced disease and symptoms not adequately addressed by non-surgical therapies, surgery may be an option. For patients with arthritis in the joint at the base of the thumb (carpometacarpal [CMC] arthritis), surgery can provide significant pain relief while preserving strength and motion in the thumb. Typically, the surgeon removes the arthritic bone (called the trapezium) through a small incision at the base of the thumb. One of the tendons in the area is then rerouted to support the thumb while it heals. After a period of immobilization and rehab, patients are able to return to full activity.

For the smaller joints of the fingers, arthroplasty (joint replacement) with silicone or pyrocarbon implants can preserve motion while relieving pain. These procedures are more commonly performed in the proximal finger joints (those closer to the wrist). For the more distal finger joints (those farther from the wrist), stability is often a more important concern, and an arthrodesis (fusion) procedure can relieve pain and provide a stable platform for pinch-and-grip activities.

Dr. Michael Potter is with Sentara Martha Jefferson Orthopedics.

This column, which promotes community health, is sponsored by Sentara Martha Jefferson Hospital, Region Ten Community Services Board, Thomas Jefferson Health District and the University of Virginia Health System.

See the article here:
Vital Signs: Treatment options can ease pain of hand and wrist arthritis - The Daily Progress

Read More...

Palmerston North Hospital calls on neighbour to treat arthritis patients – Manawatu Standard

Sunday, February 12th, 2017

NICHOLAS MCBRIDE

Last updated17:58, February 12 2017

Palmerston North Hospital will have to call on a neighbouring region to help treat its arthritis patients.

A new rheumatologistwas expected to start in February, after its two specialists retired and resigned,respectively, last year.

However, the new doctor will now not start until May, meaning the hospital will have to call on Hawke's Bay for support.

READ MORE: * Concerns raised over shortage of arthritis specialists and delays in replacements * Arthritis sufferer told hospital department will close - DHB denies this

That has prompted Arthritis New Zealand to say the condition is not prioritised in the health system.

Arthritis NZ chief executive Sandra Kirby said the specialist shortage was a "pretty well documented reality".

"We have been concerned for many years about a shortage of rheumatologists in New Zealand.

"It has been an issue for more than a decade. It is not a new phenomenon."

Kirby said arthritis was not viewed as a priority in the New Zealand health system, despite 620,000 people living with the condition.

"Manawatu has been well served [in the past], so this is disappointing."

She expected patients would still get a good service from the Hawke's Bay staff.

MidCentral DHB clinical services and transformation general manager Mike Grant said the new rheumatologist was relocating to New Zealand from the United Kingdom.

"Originally, the doctor was scheduled to begin earlier in 2017, however, the relocation process has taken longer than envisaged."

"In the interim, a rheumatologist based in the Hawke's Bay will provide follow-up clinics at MidCentral Health, as well as seeing urgent patients referred to the service.

"Support for inpatient management will also be available to senior medical officers, ensuring continuity of the rheumatology service for all patients requiring this care."

In a MidCentral committee agenda, Grant said rheumatology patients tended to have a higher proportion of chronic, long-term conditions, rather than acute cases that require urgent attention.

"These arrangements will ensure there is capacity to see any urgent patients referred while we await the arrival of our new specialist."

-Stuff

Read more:
Palmerston North Hospital calls on neighbour to treat arthritis patients - Manawatu Standard

Read More...

Fit & Proper: How to prevent the onset of arthritis – Business Standard

Sunday, February 12th, 2017

Statistically there are more than 10 million cases of arthritis reported in India every year, and innumerable others that arent. Clinically speaking arthritis is more commonly seen in women, since they have a tendency to gain weight, especially Indian women, which in turn stresses the joints leading to the condition. Erratic intake of calcium is another precipitating factor. Osteoarthritis is the most common form of arthritis, which causes pain, inflammation and reduced motion in the joints. It typically affects the hands, knees, hips and the spine. The condition withers the cartilage, the slippery tissue that covers the ends of bone in a joint. When a person loses cartilage, the bones rub together, this can permanently damage the joint. Rheumatoid arthritis on the other hand is an autoimmune disease, which affects the entire body since there is an abnormal response of the immune system. In rheumatoid arthritis, the body's immune system attacks its own tissues, including joints and internal organs in some cases. Rheumatoid Arthritis is more incapacitating than osteoarthritis. The pain associated with arthritis depends on the stage, the symptoms are directly proportional to the stage. The early arthritis patients respond better as opposed to patients with an advanced condition, who have constant pain in joints throughout the day. The most commonplace joint to be affected is the knee, though there are also arthritis cases of shoulder, hip and other smaller joints. Early signs shall help more so with inflammatory arthritis, for instance Rheumatoid arthritis. Patients may complain of early morning stiffness, and if someone has this disorder the stiffness should last 30 to 40 minutes. It is suggested that if a patient goes through morning stiffness, and swelling in small joints, they should consult an Orthopedic Surgeon or a Rheumatologist at the earliest, since this condition if unchecked can be extremely detrimental for the joints. People in India normally resort to self-medication for alleviating pains. They allow the condition to go undiagnosed for years, and consult a clinician only when hands and feet get deformed and the pain becomes unbearable.

There is very little awareness concerning arthritis; therefore, it is imperative that people know more about it and how dreadful it can be. If left unattended, its most devastating side effect being that it can leave people incapacitated for life.

Ways to prevent and treat arthritis

Next week: How to spot early signs of thyroid-related diseases and treat them

Aashish Chaudhry

http://bsmedia.business-standard.com/_media/bs/wap/images/bs_logo_amp.png 177 22

See the original post:
Fit & Proper: How to prevent the onset of arthritis - Business Standard

Read More...

Beat Arthritis by checking your teeth – The Nation Newspaper

Saturday, February 11th, 2017

Gum/tooth disease is a common complaint that comes with aging, which is the reason many elderly people lose their natural teeth with age. One thing many physicians and their patients are yet to realize is that tooth/gum trouble is a symptom of a much more serious health challenge. Pain in the joints is a well known symptom of Rheumatoid Arthritis, but a much less known fact is the relationship between arthritis and gum/tooth troubles. Physician/researcher Al Sears points this out when he says, But one problem with modern medicine is that specialists often miss the bigger picture. Every part of your body is biologically connected. And whats going on in your mouth can reveal a lot about your health.

New research studies published in the Nature Reviews Rheumatology journal provide evidence to corroborate Sears theory. Sears states, In a study published just a few weeks ago in the journal Nature Reviews Rheumatology, researchers followed 6,616 people for more than 10 years. They found that those who had moderate to severe gum disease had more than twice the risk of developing rheumatoid arthritis.

Sears continues, Other research suggests that clearing up gum disease could help prevent or treat Rheumatoid Arthritis. Case Western Reserve University School of Dental Medicine found that people who were treated for gum disease had significantly more improvement in their Rheumatoid Arthritis symptoms than those who were only treated for their Rheumatoid Arthritis.

There are a lot of bacteria in your mouth, something like 100 billion bacteria. The bacteria form a sticky film called plaque that hardens into tartar. Plaque and tartar cause inflammation in your gums. If you have plaque and tartar buildup, your gums may bleed when you brush your teeth. But those bacteria can also travel around your body. And left unchecked, they can cause inflammation in other parts of your body, like in your joints.

The good news is that treating gum troubles could treat or prevent Rheumatoid Arthritis. The Case Western Reserve University School of Dental Medicine study found that people who were treated for gum disease had significantly more improvement in their RA symptoms than those who were only treated for their Rheumatoid Arthritis. Sears continues, Scientists found that one of the bacteria involved in Periodontitis may trigger a process called citrullination. Researchers who study this process believe its what sparks the immune system and drives the cascade of events that lead to Rheumatoid Arthritis.

The secret of Healthy Teeth is therefore Healthy Joints. To prevent and treat your RA, simply take care of your teeth. Besides just brushing and flossing, do the following for healthy teeth AND joints:

To do this, in the morning before eating or drinking anything, gently swish one tablespoon of coconut oil in your mouth and between your teeth for 10 to 20 minutes. Dont swallow. Spit the used oil into the trash or a jar, not the sink. It will clog your plumbing. Rinse your mouth and brush your teeth as normal.

Read the original post:
Beat Arthritis by checking your teeth - The Nation Newspaper

Read More...

Bacteria links Crohn’s disease to arthritis — ScienceDaily – Science Daily

Friday, February 10th, 2017
Bacteria links Crohn's disease to arthritis -- ScienceDaily
Science Daily
Patients with Crohn's disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain. In Crohn's ...

and more »

Continue reading here:
Bacteria links Crohn's disease to arthritis -- ScienceDaily - Science Daily

Read More...

NIH awards $1.7 million to develop new arthritis treatment via silk … – ScienceBlog.com (blog)

Friday, February 10th, 2017

A twisted ankle, broken hip or torn knee cartilage are all common injuries that can have medical ramifications long after the initial incident that causes them. Associated pain, inflammation, joint degeneration and even osteoarthritis can sideline a variety of different people: athletes, weekend warriors and patients who are either aging or inactive.

A team from Washington University in St. Louis was awarded $1.7 million from the National Institutes of Health (NIH) to develop a new therapeutic treatment that can deliver disease-modifying compounds in a manner to delay the development of inflammation, joint degeneration and arthritis with all the associated discomfort, disability and pain.

Were starting to see that many areas cant be reached via oral drug delivery, said Lori Setton, the Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering at the School of Engineering & Applied Science. For example, synovial joint fluid in the knee is almost optimized to rapidly clear compounds out of the joint. So were trying to trick the joint into being a good host for the therapeutic drugs we are delivering.

Setton, whose lab focuses on the role of mechanical factors in the breakdown and repair of soft tissues, says an intracellular compound called nuclear factor kappa B (NF-kB) is a main culprit in cellular breakdown, inflammation and pain after an injury. Shes working in the lab on a new solution using silk to deliver two specific molecules that can inhibit NF-kB at the site of a fracture or injury in an effort to stave off long-term joint damage.

Silk naturally doesnt interact with water, and, when you mix it with these molecules that also dont interact with water, they bind to each other very strongly, Setton said. We believe these selective compounds are therapeutically effective, but weve never been able to get them to their target site. By delivering them with the silk, we hope to get large doses to the target site with low toxicity and to have them remain in that compartment for longer periods of time.

In preliminary work with Tufts University investigator David Kaplan, Setton showed that model compounds can reside in the joint space about 5 times times longer if delivered with silk microparticles than if delivered alone. Silk is an attractive delivery vehicle because of its long history of safe clinical use, and Kaplan has received NIH support to promote translational uses of silk for medical and other applications. It was initial work in delivering silk to the knee joint that drove Setton to identify a suitable, disease-modifying compound for treatment of arthritis through collaborations with the Musculoskeletal Research Center at the Washington University School of Medicine.

Setton and her co-investigators at the School of Medicine including Youssef Abu-Amer, professor of orthopaedic surgery; Farshid Guilak, professor of orthopaedic surgery; and Gabriel Mbalaviele, associate professor of medicine in the Division of Bone and Mineral Diseases will soon start testing the new delivery system in animal models.

Delivering drugs orally to combat NF-kB-mediated problems at specific locations in the body, such as the injured knee, can be associated with harmful biological functions, Abu-Amer said. So this type of site-targeted approach to inhibit elevated NF-kB is essential if we want to provide effective treatment to the targeted site.

According to Setton, the enhanced drug-delivery system has the potential to prevent the onset and progression of joint damage in patients suffering from acute injuries, like minor joint fractures, ligament or meniscal tears.

Patients with joint trauma tend to go on to develop osteoarthritis at a higher rate compared to someone who doesnt have the injury, Setton said. Its a whole different type of arthritis development that we dont know a whole lot about, but we believe we can intervene early with new drug delivery and treatments, and prevent onset at a later stage.

Go here to see the original:
NIH awards $1.7 million to develop new arthritis treatment via silk ... - ScienceBlog.com (blog)

Read More...

Etanercept vs. Monoclonal Antibody Tx Assessed in Rheumatoid Arthritis – Monthly Prescribing Reference (registration)

Friday, February 10th, 2017
Etanercept vs. Monoclonal Antibody Tx Assessed in Rheumatoid Arthritis
Monthly Prescribing Reference (registration)
HealthDay News For patients with rheumatoid arthritis, etanercept is associated with lower risk for general infections and tuberculosis compared with monoclonal antibody treatment, according to a meta-analysis published online February 3 in the ...

See the original post:
Etanercept vs. Monoclonal Antibody Tx Assessed in Rheumatoid Arthritis - Monthly Prescribing Reference (registration)

Read More...

Bacteria links Crohn’s disease, arthritis, researchers find – Cornell Chronicle

Friday, February 10th, 2017

Dr. Kenneth Simpson/College of Veterinary Medicine

E. coli bacteria (red), which are abundant in the immunoglobulin-A-coated microbiota of patients with a Crohn's disease-associated condition called spondyloarthritis, promote systemic inflammation. The blue circular structures depict the nuclei of cells called epithelial cells.

Patients with Crohns disease, a type of inflammatory bowel disease (IBD) that causes abdominal pain and diarrhea, can also experience joint pain. In Crohns disease, which affects about 800,000 Americans, the immune system can attack not only the bowels, but the musculoskeletal system as well, leading to spondyloarthritis, a painful condition that affects the spine and joints.

Research published Feb. 8 in Science Translational Medicine helps explain the connection between these seemingly unrelated symptoms, and could help physicians identify Crohns disease patients who are more likely to develop spondyloarthritis, enabling them to prescribe more effective therapies for both conditions.

New technology helped the researchers identify a type of E. coli bacteria found in people with Crohns disease that can trigger inflammation associated with spondyloarthritis, according to the study led by principal investigator Dr. Randy Longman and scientists from the Jill Roberts Center for Inflammatory Bowel Disease at NewYork-Presbyterian and Weill Cornell Medicine and the Jill Roberts Institute for Research in Inflammatory Bowel Disease at Weill Cornell Medicine, microbiologists at Cornells College of Veterinary Medicine, and rheumatologists at the Hospital for Special Surgery (HSS).

The researchers used fecal samples from patients with IBD to identify bacteria in the gut that were coated with antibodies called immunoglobulin-A (IgA) that fight infection. Using flow cytometry, in which fluorescent probes are used to detect IgA-coated bacterial species, the researchers discovered that IgA-coated E. coli were abundant in fecal samples from patients with both Crohns disease and spondyloarthritis. Using patient samples and mouse models, they then linked these bacteria to cells that help regulate inflammation, known as Th17 cells, in people with autoimmune disorders.

Our findings may allow us to develop diagnostic tools to stratify Crohns patients with spondyloarthritis symptoms as well as patients at risk, said senior author Longman, assistant professor of medicine and director of the Jill Roberts Institute Longman Lab at Weill Cornell Medicine.

The investigators found that patients with Crohns disease and spondyloarthritis had higher levels of Th17 cells and that a protein called IL-23 triggers their activity. With the recent FDA approval of an anti-IL-23 medication for Crohns disease called ustekinumab, the findings may help physicians select therapies that target symptoms of both the bowels and the joints in these patients, Longman said.

Just sequencing the gut flora gives you an inventory of the bacteria, but does not tell you how they are perceived by the host immune system, said co-author Dr. Kenneth Simpson, professor of small animal medicine at the College of Veterinary Medicine, whose laboratory characterized theE. coli identified in the study. This approach is giving you a functional readout versus just an inventory.

Longman led the translational study along with co-author Dr. Ellen Scherl, director of the Roberts Center at NewYork-Presbyterian and Weill Cornell Medicine and the Jill Roberts Professor of Medicine at Weill Cornell Medicine, in collaboration with HSS rheumatologists and co-authors Dr. Lisa Mandl and Dr. Sergio Schwartzman. Initial funding for the work was provided by a pilot seed grant to foster collaborations between researchers in Ithaca and New York City, and has since been funded by the New York Crohns Foundation, the Charina Endowment Fund, the Center for Advanced Digestive Care, the Jill Roberts Institute for Research in IBD and the National Institutes of Health.

We knew there was smoke, but we didn't know where the fire was, said Simpson, who added that each collaborator provided unique expertise to uncover the findings. If we can block the ability of bacteria to induce inflammation, we may be able to kick Crohns disease and spondyloarthritis into remission.

Longman added: In IBD therapy, this is a step toward precision medicine to be able to clinically and biologically characterize a subtype of disease and then select the medicine that would best fit the patient with this type of inflammation. The results of this innovative study will start to inform our decision of which of our available medications will give the best chance of helping the individual patient.

Jen Singer is an editorial consultant for Weill Cornell Medicine.

Here is the original post:
Bacteria links Crohn's disease, arthritis, researchers find - Cornell Chronicle

Read More...

8 Women Share The Diet Changes They Made To Get Their Rheumatoid Arthritis Under Control – Prevention.com

Thursday, February 9th, 2017

Prevention.com
8 Women Share The Diet Changes They Made To Get Their Rheumatoid Arthritis Under Control
Prevention.com
An estimated 1.5 million Americans suffer from rheumatoid arthritis, and it can sometimes feel like there are just as many theories about how to manage its symptoms. "There's no one-size-fits-all approach," says Ashley Boynes-Shuck, who's been living ...

Originally posted here:
8 Women Share The Diet Changes They Made To Get Their Rheumatoid Arthritis Under Control - Prevention.com

Read More...

Page 71«..1020..70717273..»


2024 © StemCell Therapy is proudly powered by WordPress
Entries (RSS) Comments (RSS) | Violinesth by Patrick