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HighlightsCastor oil can reduce the pain of arthritis Castor oil can reduce swelling of joints

Benefit of Castor Oil in ArthritisArthritis means that the pain of arthritis can only be understood by the one who suffers it. The pain of arthritis in the joints of the body is unbearable. Due to the weakening of the bones, there is pain in the joints of the body. Apart from this, due to sudden injury, the pain of arthritis starts bothering again and again. Because of this, even walking becomes difficult. By the way, the pain of arthritis can be relieved in many ways. But the use of castor oil can give more benefits.

According to experts, this oil can be used to get relief from the pain of arthritis. Let us know how castor oil can be useful in arthritis.

Castor oil with special propertieshealth site According to this, castor oil is very useful for internal and external health of the body. The use of castor oil can be helpful in treating all kinds of diseases. Castor oil has anti-inflammatory, anti-oxidant, anti-bacterial and anti-fungal properties. Many natural elements are also present in it. Which provide relief from the pain of Arthritis.

Read also: Junk food and smoking increasing the risk of heart attack? Learn Reality

beneficial castor oilCastor oil is beneficial in relieving pain and swelling in joints and muscles.Castor oil can be used to strengthen the bones of the body of young children.After massaging with castor oil, it helps to improve blood circulation.

Castor Oil for ArthritisThe use of castor oil can be beneficial to get relief from the pain of arthritis. For its use, soak a cloth overnight in castor oil and then squeeze it and place it on the painful area. To get relief from pain, keep a hitting pad on it for half an hour. Apart from this, by doing this, joint pain can also be relieved.

Read also: Can eating non-veg cause obesity? Know the reality here

Castor oil can be useful in some way in arthritis. This can give relief in pain to a great extent.

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Benefits of castor oil: Castor oil is very useful in arthritis, know its health benefits - Hunt Daily News

Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation, swelling, and pain in a persons joints. The condition is chronic and progressive and can be disabling. Symptoms develop over time, with early signs including fatigue, joint tenderness, and pain.

According to the Arthritis Foundation, 1.5 million people in the United States have RA. Biological females are three times more likely than biological males to develop RA.

This article looks at the early signs that a person might have RA. It also discusses later stage symptoms and when to speak with a doctor.

If a person has an autoimmune disease, such as RA, their immune system mistakes the bodys cells for foreign invading cells. Their immune system then releases inflammatory chemicals to attack them.

If someone has RA, their immune system attacks the tissue called synovium. This tissue lines the joints and produces fluid that helps them move smoothly.

RA most commonly affects the joints in the hands, wrists, and knees. It causes the lining of the joints to become inflamed, which can damage their tissues. The damage that RA causes can lead to a person developing long lasting or chronic pain. It may also cause deformities and a lack of balance.

RA may also affect other tissues in a persons body, including organs such as the heart, eyes, and lungs.

A person can develop RA at any stage in their life. However, the condition most commonly develops between the ages of 30 and 50 years old.

People with early stage RA may not see redness and swelling in their joints. However, they may experience some joint tenderness and pain. A general feeling of stiffness throughout the body in the morning may suggest a person has RA.

Someone with early stage RA may also experience fatigue. Fatigue can be both mental and physical and can cause a person to feel extremely tired, preventing them from performing their usual daily tasks.

The inflammation that comes with RA may cause a person to develop a fever. A person has a fever if their body temperature rises above the typical range of 98100F (36.737.7C). Fever is a common sign of inflammation in people with autoimmune diseases.

A person may also experience weight loss due to the inflammation from RA. In addition, someone with fatigue and fever may experience appetite loss, which can contribute to weight loss.

As the inflammatory process of RA progresses, symptoms can worsen. A person may experience more extreme fatigue and continue to have fevers and lose weight.

Common symptoms of RA include the below.

Joint pain and stiffness is the most common symptom of RA. The persons joints may become red, warm, swollen, and tender to touch.

Joint stiffness is often at its worst in the morning. It can last for several hours or the entire day, depending on the severity of the disease.

RA tends to cause pain and stiffness in the hands and feet first. However, a person may experience these symptoms in the knees or shoulders.

RA will often affect both sides of a persons body. In fact, finding symmetrical symptoms across the joints is key to how doctors diagnose RA.

RA can cause damage to a persons ligaments and tendons. This can make it more difficult for them to achieve a typical range of motion in the joints. This can result in a person being unable to bend or straighten certain joints.

This can have a negative effect on their quality of life, as it may restrict them from doing things they were once able to do.

Inflammation from RA can cause nerve compression, which can affect the nerves around the joints. This can cause a person to develop damaged nerves, called peripheral neuropathy.

This nerve damage can cause a loss of sensation, and people may experience numbness or a tingling sensation in their hands and feet.

Rheumatoid nodules are lumps that develop under a persons skin. They are a common symptom of RA.

These lumps often appear next to the joints that the RA is affecting. However, rheumatoid nodules do not require treatment and are not contagious or dangerous. They can sometimes indicate that a person could make improvements to how they manage their RA.

RA mostly affects a persons joints. However, the disease can also affect other parts of the body, including the heart, lungs, and eyes.

This can cause a variety of other symptoms, including the following.

RA can affect a persons eyes. This can cause them to have dry eyes, the most common type of eye involvement in RA. People with RA can also experience increased sensitivity to light and trouble seeing clearly.

They may also experience eye pain and redness of the eye when RA inflammation affects the eye tissues, such as the iris or the uvea. This involvement is called iritis or uveitis, respectively.

RA can cause a person to have a dry mouth and inflamed gums.

People may also develop irritated gums or a gum infection.

According to a 2020 meta-analysis of 18 studies, up to 19.5% of people with RA may also have Sjgrens disease. This is a chronic autoimmune disorder affecting the moisture-producing glands, including those in the mouth.

RA can cause damage to a persons lungs, particularly in the form of interstitial lung disease, an umbrella term for a group of conditions that cause inflammation and scarring in the lungs.

This can cause the person to experience shortness of breath and may lead to chronic lung disease.

Inflammation can affect a persons blood vessels.

This can cause damage to their skin and nerves, resulting from inflammation of the veins, arterioles, and venules. The latter involvement can develop as a peripheral neuropathy.

A person with RA may also have anemia or a lower than expected red blood cell count due to the chronic inflammation.

A person with RA may experience inflammation of the heart. This can damage the heart muscle and the surrounding areas.

The chronic inflammation that RA causes can also increase the risk of developing coronary artery disease (CAD).

The inflammation affects the lipid profile of people with RA, contributing to the onset of CAD. People with RA are almost twice as likely to experience heart conditions, such as angina and congestive heart failure, as those without.

Some people with RA experience weight loss.

However, others may find that painful joints make it hard to exercise.

This can cause the person to gain weight. People who maintain a moderate weight can reduce their risk of high cholesterol, heart disease, and high blood pressure.

To treat RA effectively, it is important that a person gets an accurate diagnosis as soon as possible. If they experience symptoms of RA, they should seek medical help.

If a doctor suspects RA, they may arrange for the person to consult a rheumatologist, a doctor with specialized training in treating arthritis.

A doctor will first ask about the persons medical history before discussing joint symptoms. They will want to know about any pain, tenderness, stiffness, and any mobility difficulties they might be experiencing.

The doctor may also want to know about any family history of autoimmune diseases.

They will then carry out a thorough physical examination, documenting vital signs, examining joints, and looking for tenderness, swelling, or warmth of the joints. The doctor may also order blood and imaging tests to support the suspected diagnosis.

RA is a chronic autoimmune condition.

If a person has RA, their immune system confuses the bodys own cells for foreign invading pathogens. This causes the immune system to attack its own cells.

The immune system will also attack synovium, the tissue that lines the joints and produces fluid that helps them move smoothly.

RA tends to affect the joints in the hands, wrists, and knees.

Common symptoms of RA include swelling and pain in the joints, fatigue, fever, decreased function of joints, and compromised mobility.

Anyone who thinks they may have RA should consult with a doctor as soon as possible.

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How to tell if you have rheumatoid arthritis - Medical News Today

Acquired hemophilia is a rare condition that is a disease of the immune system. With this condition, the bodys immune system targets clotting factors in the blood, such as factor VIII. Acquired hemophilia can occur in people that have rheumatoid arthritis and can have serious consequences.

Hemophilia is a disorder that stops the blood from clotting properly. For most people with the condition, it is an inherited disease. Reduced levels of certain blood clotting factors can cause bleeding and trigger serious health problems in some severe cases. There are two types of hemophilia: A and B. Both can be congenital, which means a person inherits it, or they can acquire it, meaning it develops later in life.

Rheumatoid arthritis is an autoimmune disease that mainly affects the joints. The bodys immune defenses mistakenly attack the joints in the hand, wrist, or knee, causing inflammation and damage. Besides chronic joint pain, balance problems, and deformed bones, the condition can also affect organs such as the lungs, heart, and eyes.

A link between both conditions exists. Acquired hemophilia has associations with rheumatoid arthritis in about 48% of cases, and people tend to have a poorer prognosis.

Keep reading to learn more about the link between hemophilia and rheumatoid arthritis, including diagnosing and treating both conditions.

Acquired hemophilia is similar to congenital hemophilia in that it can cause bleeding. However, the acquired form of the disease is a rare immune system disorder that involves the immune system attacking healthy cells.

Unlike congenital hemophilia, acquired hemophilia does not pass down through generations of a family. Additionally, congenital hemophilia only affects males, whereas acquired hemophilia can affect people of any sex.

In acquired hemophilia, the body makes antibodies that attack proteins, known as clotting factors. With these proteins depleted, the blood does not clot as it should. An example of an affected clotting factor is factor VIII. When blood clots, it clumps together at the site of a wound like a plug.

People who have acquired hemophilia can experience a range of serious complications of the disease due to atypical and uncontrolled bleeding into the soft tissue, skin, and muscles. Sometimes this happens spontaneously or due to surgery or trauma.

According to a recent case report, acquired hemophilia can have links to cancer, pregnancy, certain medications, or autoimmune conditions, including:

However, half of all cases of acquired hemophilia have no identifiable cause.

Both acquired hemophilia and rheumatoid arthritis are immune disorders, where the body attacks its own healthy cells.

Many people with a diagnosis of one autoimmune condition go on to develop other autoimmune disorders. Researchers working on a 2022 study found that people with rheumatoid arthritis often have polyautoimmunity.

Polyautoimmunity refers to the state in which a person has more than one autoimmune disease.

Symptoms can occur when the blood is not clotting properly. People with acquired hemophilia might experience the following:

According to a 2022 case report, a 69-year-old female, who had lived with rheumatoid arthritis for 25 years, experienced a severe nosebleed and bleeding into her muscles and skin. When doctors performed tests, they found that she had factor VIII clotting factors below healthy levels in her blood.

An older case report from 2016 involved another 69-year-old woman who required hospitalization. Doctors diagnosed her with rheumatoid arthritis 6 years before. Four months before the hospital admission, she experienced:

Doctors can diagnose both conditions by assessing their symptoms and results from the laboratory.

Doctors may diagnose acquired hemophilia if a person is experiencing atypical bleeding that has only started recently. They use a variety of specialized blood tests that measure how long it takes the persons blood to clot. Some tests might include:

People who are most susceptible to acquired hemophilia include the elderly and those who are about to or have recently given birth.

People with rheumatoid arthritis have swollen and tender small joints. Symptoms can include:

Diagnosing this condition involves reviewing the above symptoms, carrying out a physical examination, taking X-rays, and doing lab tests.

Learn more about how doctors diagnose rheumatoid arthritis.

The main goals of managing acquired hemophilia disease are:

As acquired hemophilia is rare, developing most therapies involves using anecdotal or small case reports. Treatments are highly specialized and depend on many factors, including age, overall health, tolerance for certain medications, and the underlying cause.

Some medications include:

When a persons acquired hemophilia has links to another autoimmune condition, such as rheumatoid arthritis, doctors most commonly write a combined prescription for methylprednisolone and cyclophosphamide. Both medications help prevent the overactive immune system from attacking healthy cells.

Research from 2018 shows that acquired hemophilia is a life threatening condition, and 515% of people with the disease die.

When doctors diagnose a person with acquired hemophilia early and take action to treat the condition sooner, a persons outlook can be more positive. However, some healthcare professionals can miss or misdiagnose the condition.

Additionally, treatment options come with risks. Therefore, people with acquired hemophilia need regular monitoring from their doctors.

Hemophilia may be congenital or acquired. People with acquired hemophilia can have other autoimmune conditions, such as rheumatoid arthritis, at the same time.

Many laboratory tests can help diagnose and treat this condition. Doctors prescribe medications to people with the following goals: controlling bleeding, eradicating the inhibitor, and treating the underlying disease where possible.

The sooner doctors diagnose and treat a person with acquired hemophilia secondary to rheumatoid arthritis, the better their chances of survival.

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What is the link between hemophilia and rheumatoid arthritis? - Medical News Today

The BDN Opinion section operates independently and does not set newsroom policies or contribute to reporting or editing articles elsewhere in the newspaper or onbangordailynews.com.

Most of the consequences of the Supreme Courts June ruling overturning the landmark Roe v. Wade decision will likely be less dramatic than the case of a 10-year-old girl from Ohio, a victim of rape, who was taken to Indiana for abortion care because of restrictions in her home state. But for the women, girls and others impacted, the results may be no less harmful and heartbreaking.

Already, we are seeing that states attempts to severely restrict abortion are impacting people who arent seeking abortions and, in fact, may never have them. Women in several states with bans or stringent restrictions on abortion are already finding it difficult to obtainmedication they need for every day living.

Drugs that help women live with cancer, lupus and arthritis are being restrictedbecause they can also be used to induce abortion or are part of the care after miscarriages and ectopic pregnancies.

One such drug is Methotrexate, a drug used to treat arthritis, lupus, cancer and Crohns disease.

Dana Chabot of Portland was diagnosed with juvenile arthritis before her third birthday. She has taken a combination of medications, sometimes including Methotrexate, to manage day-to-day living, such as getting out of bed, walking up and down stairs and attending college and now working.

If she is unable to obtain the medication her body needs, her life would deteriorate quickly.

Although Gov. Janet Mills and Democratic lawmakers have pledged to keep abortion legalin Maine, Chabot worries that such attitudes and laws can change with different people in office.

As of right now, Maine is a safe state. But, in the future, if Maine becomes one of those states that bans abortion and I cant get the proper medication, its going to be a really big issue, she said during a recent interview at her familys home in Portland. Her mother, Barbara, is a friend of mine from college.

I do worry that Maine will suddenly become a state I wont be able to live in, she added.

On the surface, life may look normal for Chabot, 22. She was a cheerleader at Deering High School and actively involved in theater. She graduated from college in May and works two jobs.

But, because of her arthritis, a day at work or a night out with friends can mean hours of pain and difficulty moving through her daily routine.

Like others with hidden disabilities, Chabot has had to endure doubts and insensitive advice from doctors, teachers and others. Suggestions that her illness is in her head are as frequent as they are mean. One school counselor told her to get a boyfriend so she could focus on him rather than her problems. Doctors have been dismissive as well.

Arthritis, and the health consequences that can come with it headaches, joint pain, imobility, even blindness in some cases are very real. One in four American adults have arthritisand 300,000 American children have juvenile arthritis. It takes medication, and a lot of careful planning, to keep the pain and loss of mobility at bay.

At times, it feels like doctors and insurance companies which have to approve any changes in medication or other therapies control her body, Chabot said.

Right now, I have very little control over my own body. and lawmakers are telling me there is even less I can do with my own body. Its awful, but I have to fight for the right to just function normally, she said.

We should all be able to agree that no one should have to fight for the right to function normally, that no one should have to fear that they cant get the medications that make their life liveable.

Supporters of bans on abortion will likely argue that this is not what they intended. But, the push to outlaw abortion without full consideration of the unintended consequences is irresponsible and cruel.

Girls like the 10-year-old in Ohio and women like Dana Chabot any humans, in fact should not have to live in fear that lawmakers, and not themselves, will control what happens to their bodies.

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Abortion bans are harming women with cancer and arthritis. A Portland woman fears it can happen here. - Bangor Daily News

improve thyroid gland function

Experts say that due to the deficiency of copper, thyroid glands malfunction. In this case, copper water balances the inefficiencies of the thyroid gland. If you have thyroid problems, drinking water in a copper vessel every day is a healthy option for you.

Copper water benefits your health by strengthening bones. This makes it an excellent treatment for arthritis. The anti-inflammatory effect of copper is of great benefit to individuals with arthritis. It also reduces the problem of joint pain.

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Copper water removes pollutants and harmful germs. Along with this, it reduces stomach irritation, and promotes metabolism and improves digestion.

Copper water promotes proper blood circulation. and dilates blood vessels. In this way the risk of heart related diseases is reduced.

Ayurveda experts state that the benefits of copper water include fighting the harmful effects of free radicals. Due to which the problem of aging is reduced.

Water stored in a copper vessel prevents oxidants from working faster or better, thereby reducing the risk of stroke.

The right amount of copper in the body works to increase your metabolism. It also helps in losing weight in a healthy way by burning fat.

Copper is an important mineral. The body requires it at the proper level to prevent hemoglobin related disorders.

According to experts, copper has natural antibacterial properties that can reduce infections. In such a situation, storing water in a copper vessel in the rain and drinking it can save you from the infection spreading in this season.

Disclaimer: This article is for general information only. It cannot in any way be a substitute for any medicine or treatment. Always contact your doctor for more details.

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These 10 diseases including thyroid-arthritis will remain under control, just drink water every day like this - News Day Express

Although there are several new technologies and techniques improving outcomes for sports medicine and orthopedic patients, many surgeons are not incentivized to use them, according to Kevin Stone, MD.

Dr. Stone is an orthopedic surgeon leading the Stone Clinic in San Francisco. He specializes in robotic-assisted surgeries and the use of biologics for joint preservation, holding more than 40 U.S. patents and lecturing worldwide on cartilage and meniscal treatments.

He recently spoke with Becker's about innovations shaping patient care and the roadblocks keeping providers from onboarding new technology and techniques.

Editor's note: Responses were lightly edited for clarity and length.

Question: What are the biggest challenges facing the industry right now?

Dr. Kevin Stone: The industry that I work in is in sports medicine and arthritis. So I see athletes of all ages, and I see people who are developing arthritis or developed arthritis and want to stay active and keep doing the sports they love to do. In my space of the world, it's really educating people that taking tissues out, such as the meniscus cartilage, or shaving the cartilage, the particular cartilage away, or leaving people with unstable knees leads them to arthritis. And we have developed the techniques now for replacing the meniscus, for regrowing the cartilage, for rebuilding the ligaments accurately so that if people and doctors knew that it's not a good idea to take someone's meniscus cartilage out for example, it's much better if it's damaged to repair it, to regrow it or to replace it then we would save tens of millions of people the arthritis they would later develop.

The biggest challenge is educating doctors and patients to repair and replace tissues, not to take them out. The second biggest part in the industry is the old thinking that artificial joint placement means patients can't return to sports or should stay home and rest their knee, or only do limited activities. That's simply not true anymore. In the age of robotics, what's happened is that robotics have permitted us to become much more precise as partial and total knee replacement surgeons. And when we do a total knee replacement now, we don't need to use cement anymore. So we don't need to limit the patient's activities because they're not going to knock the implant loose, and educating patients and doctors about that has been much harder than we ever thought, because so many patients are being told they can't be active and so many doctors are still doing procedures with old technology.

Q: What technologies and techniques are improving efficiency and quality of care?

KS: This is the era of growth factors and lubrication. So the injection therapy has gotten so good now that many people who once were being brought to surgery for certain types of injuries are being treated successfully with injections, and this is the abandoning of cortisone and then moving toward anabolic injections, growth factors and lubrication.

Q: How do you expect the industry to evolve in the next three to five years?

KS: We will start to get birth tissues approved, which will be much more potent anabolic therapies both with growth factors and anti-inflammatories and cellular recruitment factors, so that the injection therapies will become even more effective. Number two, robotics will expand and patients will demand they be treated with more modern techniques, and that will permit people to be returned to sports, and be much more active than they have been in the past. So I think those two things are probably the biggest changes.

Q: If you could change one thing about the industry, what would it be?

KS: I would improve the incentives for innovation, because right now doctors are not incented to innovate, and that inhibits a lot of the development of the technology and techniques that we would like to use and develop.

[This is partially due to] cost, because robotics are more expensive at first although they're cheaper in the long run and in part, health programs, insurance programs that do not encourage innovation. And because most people only stay with their healthcare plan for two or three years, the insurance companies and healthcare plans don't really care about the long-term outcomes for patients, because those people will not be their patients in the long term. So the incentive is all wrong.

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Repairing and replacing, not removing, is the future of orthopedics: Dr. Kevin Stone - Becker's Orthopedic & Spine

Osteoarthritis (OA) is a degenerative joint disease that can cause pain, stiffness, and limited range of motion. OA can affect any joint, including the wrist.

The symptoms of wrist OA include pain, swelling, and a reduced range of motion in the wrist and hand. Wrist OA can lead to structural changes in the hand and limit a persons ability to perform daily tasks.

This article looks at wrist OA in more detail, including its symptoms, diagnosis, and treatment.

OA happens when cartilage wears away. Cartilage is a smooth, flexible tissue that cushions and protects the ends of bones, allowing them to glide smoothly over each other.

When the cartilage at the ends of wrist bones wears away, the bones may rub together, creating friction and swelling. A person may also experience pain because the exposed bone has nerve endings. Eventually, the wrist joint may change shape, causing more pain and reducing the range of motion in the wrist and hand.

The wrist connects the hand to the forearm and comprises several bones. The radius and ulna are the forearm bones. There are eight small carpal bones at the base of the hand, arranged in two rows of four. In a healthy wrist, slippery cartilage covers the joint surface of each bone.

In wrist OA, the cartilage wears away, causing the bones to rub against each other. Injuries such as a broken wrist can accelerate cartilage loss and OA symptoms.

The symptoms of wrist OA can include:

Wrist OA can cause various complications, including:

To diagnose wrist OA, a doctor will first perform a physical exam and take a persons medical history.

They may also order X-rays to help identify structural changes in the wrist and hand and to rule out other causes.

Although OA does not lead to blood abnormalities, a doctor may order a blood test to help rule out other causes, such as rheumatoid arthritis.

If a doctor suspects an infection in the wrist, they may order an arthrocentesis, also known as synovial fluid analysis. This procedure involves taking a small sample of fluid from the synovium the lining of the joint for analysis.

Although there is no cure for OA, a person can try the following management techniques to alleviate the symptoms and prevent OA from progressing:

Physical therapy can help a person maintain range of motion and keep their wrist as flexible as possible. A physical therapist can teach specific exercises that may help relieve the symptoms of OA.

These exercises may include:

Heat and cold therapy provide different benefits to people with wrist OA. Some people find that applying heat to painful joints helps relieve pain. Heat therapy, such as a paraffin wax bath, increases blood flow by dilating the blood vessels, helping ease stiffness in the wrist.

Cold therapy constricts blood vessels and can help reduce swelling and inflammation. A person can wrap an ice pack in a cloth or towel and apply it to the affected area.

Different types of wrist supports can help in different ways. Resting splints keep the hand and wrist still when a person is resting. Working splints help keep the hand and wrist in the right position when a person is using them.

It is best to ask the advice of a healthcare professional before buying wrist braces or straps to make sure that they are suitable.

Learn about more home remedies for arthritis.

Doctors may recommend the following treatments alongside the above home remedies:

Doctors may recommend various medications to relieve the symptoms of wrist OA. The options include:

If nonsurgical options are ineffective, doctors may recommend surgery. According to a 2022 article, the most common types are:

Wrist OA is a chronic condition that causes pain and stiffness in the wrist. It can also affect mobility and make daily tasks more difficult.

People can alleviate their symptoms and slow the progression of the disease by following the advice of healthcare professionals and taking their medication consistently. If a person with wrist OA does not receive treatment for it, the pain could become debilitating.

Wrist OA is a degenerative condition resulting from aging and overuse. It can lead to pain, stiffness, and a limited range of movement.

Possible complications include CTS and structural changes in the hand. Doctors can diagnose wrist OA through a physical exam and X-rays.

There is no cure for OA, but treatments are available to help ease the symptoms. Early diagnosis and treatment can help prevent further joint damage.

Originally posted here:
Osteoarthritis in the wrist: Symptoms, diagnosis, and treatment - Medical News Today

This headline-only article is meant to show you why a stock is moving, the most difficult aspect of stock trading. Every day we publish hundreds of headlines on any catalyst that could move the stocks you care about on Benzinga Pro, our flagship platform for fast, actionable information that promotes faster, smarter trading.

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J&J's Stelara (ustekinumab) Approved By FDA To Treat Pediatric Patients With Active Psoriatic Arthritis - Benzinga

Overview of the STAR Awards

The NIAMS STAR program provides supplemental funding for early-career stage investigators who have renewed their first NIAMS-funded R01 grant. The supplement enables these scientists to pursue innovative and high-risk research within the broader scope of a current NIAMS-funded, peer-reviewed research project. It also helps investigators to expand a single, structured research project into a broader multi-faceted research program. In FY 2021, two investigators received NIAMS STAR supplements.

ErikaGeisbrecht, Ph.D., is a professor of biochemistry and molecular biophysics at Kansas State University. She leads an NIAMS-supported researchproject using theDrosophilamodel to determine mechanisms that prevent protein aggregation, and ultimately cellular degeneration, in muscle. The findings will provide insight into how protein aggregates can be cleared effectively to reduce disease states and offer an opportunity to eventually develop successful therapeutic strategies to maintain healthy cells. TheSTARaward funding will support her teams effort to expand the knowledge about how protein complexes that mediate protein clearance are also possible regulators of sarcomere (the functional unit of a muscle fiber) remodeling.

Corey Neu, Ph.D., is the Donnelly Family Endowed Professor of mechanical engineering at the University of Colorado at Boulder. He leads an NIAMS-funded researchproject to establish a noninvasive imaging method of measuring cartilage strain to predict osteoarthritis development. Previous findings suggested that the novel imaging method specifically quantified cartilage tissue-level strain and structure. The STAR award will enable Dr. Neus team to explore high-risk studies developing new imaging biomarkers of cellular and nuclear structure. This knowledge may provide tissue- to cellular-scale prognostic factors for osteoarthritis, ultimately leading to diagnosis at the earliest stages when disease-rectifying therapies may be most effective.

For more information about the NIAMS STAR program, including the funding opportunity announcement and profiles of past award recipients, visit the Supplements to Advance Research (STAR) page on the NIAMS website. Additional background information is provided in theDecember 2014 letter from the NIAMS Director announcing the program.

To view profiles for the 2015 STAR awardees, visit the 2015 announcement for the STAR program.

To view profiles for the 2016 STAR awardees, visit the 2016 announcement for the STAR program.

To view profiles for the 2017 STAR awardees, visit the 2017 announcement for the STAR program.

To view profiles for the 2018 STAR awardees, visit the 2018 announcement for the STAR program.

To view profiles for the 2019 STAR awardees, visit the 2019 announcement for the STAR program.

To view profiles for the 2020 STAR awardees, visit the 2020 announcement for the STAR program.

For more information, please see the STAR funding opportunity announcement and the December 2014 letter from the NIAMS Director announcing the program.

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NIAMS Awards Two Fiscal Year 2021 Supplements to Advance Research (STAR) From Projects to Programs Enhancing NIH Support for Early-Career Stage...

GUELPH, ON eQcell Inc., a Canadian clinical-stage company, and Tillsonburg, Ontario-based private equity fund Ag Capital Canada (ACC) are pleased to announce the completion of a C$1.1 million capital investment.

eQcell is the first company in Canada to receive Health Canada authorization for the clinical

testing of mesenchymal stromal cells (MSCs) for the treatment of equine and canine arthritis. Trials of this treatment are ongoing in Canada and the US. Osteoarthritis is the most common cause of chronic lameness in horses and dogs and the fastest-growing cause of disability in humans worldwide. It has no cure.

Ag Capital Canadas investment provides eQcell with additional funding to advance its clinical stromal cell development programs and expand its therapeutic pipeline. Horses and dogs with naturally occurring osteoarthritis tend to yield data that is more clinically relevant to human osteoarthritis than do traditional laboratory animal pre-clinical models.

eQcell is following this now-established science in pursuing a One-Health approach. Success in these trials could lead to the application of the platform for human development.

Commercially, the path to market for veterinary trials is significantly shorter than for human

trials, which can result in early revenues from successful development. Importantly, safety and efficacy data from veterinary trials may significantly reduce the high rate of failure reported in late-stage human clinical trials.

This investment by ACC, an industry-specific investment fund, is a significant milestone for

eQcell, said Dr. Thomas Koch, Founder and CEO of eQcell. Furthermore, eQcell shares ACCs ambition for creating high-value companies and jobs in Canada. We look forward to working with the outstanding team at ACC and benefitting from its broad and varied local, national and international relationships in financing and business development.

John Lansink, Managing Partner at Ag Capital Canada, responded: We at Ag Capital Canada have been following Dr. Koch and his research for several years now. The pioneering work he and his team are doing has the potential to change the availability and application of osteoarthritis treatments for the animal health industry.

About eQcell

eQcell is Canadas premier clinical-stage regenerative medicine company. The mesenchymal stromal cells (MSCs) produced by eQcell are the result of 15 years of research, development and treatment of horses and dogs at the University of Guelphs Ontario Veterinary College. This institution is recognized as one of the top-five veterinary universities in the world. eQcell, together with Rood & Riddle Equine Hospital and Colorado State Universitys Translational

Medicine Centre & Veterinary Hospital, is also conducting a clinical trial in septic arthritis in horses using MSCs to treat chronic, drug-resistant infections. For more information on eQcell, visit http://www.eqcell.com

About Ag Capital Canada

Ag Capital Canada (ACC) is a private equity fund which invests in Canadian ag and food

innovation and small business growth. ACC aims to discover, develop and nurture Canadian agricultural businesses through capital investment, business-management mentorship and entrepreneurial expertise. For more information on ACC, visit http://www.agcapitalcanada.com.

Media Contacts:

eQcell Ag Capital Canada

Dr. Thomas Koch John Lansink

tkoch@eqcell.com johnl@agcapitalcanada.com

519.760.0068 519.520.5515

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eQcell and Ag Capital Canada Announce Completion of Capital Raise - BioSpace

HAMILTON, BERMUDA , July 28, 2022 (GLOBE NEWSWIRE) --

Altamira Therapeutics ("Altamira" or the "Company")(NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced the publication of a peer-reviewed article in the scientific journalInternational Journal of Oral Sciencetitled, "Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1" that covers an independently funded study evaluating novel treatment approaches for osteoarthritis (OA) conducted by a Shanghai-based research group.

Study highlights

The study used different approaches to downregulate the Jumonji domain-containing protein D3 (JMJD3) gene to assess whether this strategy would be beneficial for the treatment of OA. Nanoparticles comprising a siRNA targeting the JMJD3 gene, and Altamiras peptide-based OligoPhore delivery platform (also known as p5RHH), were used to locally downregulate the expression of JMJD3 in a mouse model of OA. The study authors observed that, the severity of joint degeneration was remarkably mitigated thanks to administration of the nanoparticles and highlighted their advantage of specifically targeting inflammation in the joint without off-target toxicities. They propose JMJD3 inhibition based on the OligoPhore platform as an innovative epigenetic therapy approach for joint diseases.

In their study, the authors pursued an epigenetic-based therapeutic approach (i.e. targeting gene regulation) to mitigate cartilage inflammation and damage in a murine model of osteoarthritis. OligoPhore was used to formulate siRNA polyplexes that inhibited chondrocyte production of a histone demethylase, JMJD3, in response to joint damage. JMJD3 is upregulated in joint injury and drives other inflammatory pathways to elicit further damage and chondrocyte programmed cell death. Injection of 2 weekly doses of OligoPhore-siRNA into the affected joint over 8 weeks significantly attenuated inflammation and preserved cartilage viability and integrity.

CSO comments

"The study's results confirm prior findings reporting the benefit of RNA therapeutics based on our nanoparticle delivery platform in models in rheumatoid arthritis and, now, osteoarthritis," commented Samuel Wickline, MD, Altamira Therapeutics Chief Scientific Officer." One of the key features of OligoPhore is the targeted delivery to inflamed tissues, making it particularly well suited for the treatment of arthritis with oligonucleotides, both in terms of efficacy and safety.

"Osteoarthritis can have a significantly detrimental impact on the well-being and quality of life of patients, often over many years or even decades, yet there is still no disease-modifying treatment available, Dr. Wickline added. While our AM-411 program is targeting rheumatoid arthritis, we envision extending its potential use to osteoarthritis as well."

Earlier this week, the Company announced the initiation of AM-411, a development program based on its proprietary OligoPhore delivery platform and siRNA targeting NF-B, for a novel generation of rheumatoid arthritis (RA) therapeutics.

Osteoarthritis to become one of the most prevalent diseases in the coming decades

Osteoarthritis is a degenerative joint disease that can affect the many tissues of the joint.1 It can degrade cartilage, change bone shape and cause inflammation, resulting in pain, stiffness and loss of mobility. OA can affect any joint, but typically affects hands, knees, hips, lower back and neck. Its signs and symptoms typically show up more often in individuals over age 50, but OA can affect much younger people, too, especially those who have had a prior joint injury. There is no cure for OA, but there are ways to manage OA to minimize pain, continue physical activities, maintain a good quality of life and remain mobile.

OA is by far the most common form of arthritis, affecting more than 32.5 million adults in the United States, according to the Centers for Disease Control and Prevention. The global prevalence of OA is increasing and the burden of the disease will rise.2 The medical cost of osteoarthritis in various high-income countries has been estimated to account for between 1% and 2.5% of the gross domestic product of these countries, with hip and knee joint replacements representing the major proportion of these health-care costs.

About International Journal of Oral Science

The International Journal of Oral Science seeks to publish all aspects of oral science and interdisciplinary fields, including basic, applied and clinical research. The Journal publishes peer-reviewed articles that describe new research results and review articles that provide succinct summaries of an area in oral science. The International Journal of Oral Science is published by Springer Nature. For more information, visit:https://www.nature.com/ijos/aims

About OligoPhore

OligoPhore is a versatile platform for safe and effective delivery of oligonucleotides such as siRNA (small interfering ribonucleic acid) into target cells. It is based on a proprietary 21-amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach other target tissues than the liver. OligoPhore protects the RNA payload from degradation in the circulation and allows for rapid cellular uptake, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Effective delivery and positive treatment outcomes have been demonstrated in more than 10 murine models of disease for targets in the NF-B family, various members of the ETS transcription factor family, and targets in the JNK and TAM pathways.

About Altamira Therapeutics

Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore / SemaPhore platforms; preclinical), nasal sprays for protection against airborne allergens and, where approved, viruses (Bentrio; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen and Sonsuvi; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit:https://altamiratherapeutics.com/

Forward-Looking Statements

This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira Therapeutics' strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the approval and timing of commercialization of AM-301, Altamira Therapeutics' need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Altamira Therapeutics' product candidates, the clinical utility of Altamira Therapeutics' product candidates, the timing or likelihood of regulatory filings and approvals, Altamira Therapeutics' intellectual property position and Altamira Therapeutics' financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira Therapeutics' capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamira Therapeutics' Annual Report on Form 20-F for the year ended December 31, 2021, and in Altamira Therapeutics' other filings with the SEC, which are available free of charge on the Securities Exchange Commission's website at:www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira Therapeutics or to persons acting on behalf of Altamira Therapeutics are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira Therapeutics does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law.

CONTACTInvestors@altamiratherapeutics.com 800-460-0183

1https://www.arthritis.org/diseases/osteoarthritis

2 Hunter DJ & Bierma-Zeinstra S (2019), Osteoarthritis, Lancet 393:1745-59.

View original post here:
Altamira Therapeutics Delivery Platform with siRNA Shown to be Effective Treatment for Osteoarthritis as Published in Peer-Reviewed Journal - BioSpace

Tamara Watkins was in her late twenties when she started to get severe back pain and headaches.

The young mother-of-three went to her GP, who ordered an x-ray, but the image showed nothing unusual.

Unsure what was wrong, her GP referred her to an osteopath in the hope that regular massage sessions would help her get on top of the chronic pain.

But Watkins' symptoms just kept getting worse.

"I remember going to the osteo and being on her table and just vomiting uncontrollably," Watkins told 9news.com.au.

"I was getting extreme headaches and tingling down my arm and into my leg."

Just turning her neck could induce sudden feelings of nausea, Watkins said.

Concerned, Watkins' osteopath pushed her to get more tests done.

An MRI revealed the cause of her debilitating pain - a bone spur on her spine brought on by osteoarthritis.

"It looked like a bird's beak and it was growing into my spine," she said.

"If it hadn't been picked up it could have resulted in more permanent damage."

Watkins needed high-risk surgery to remove the spur and replace a crushed disc.

"It took three years to find a surgeon that would operate," she said.

Doctors also gave Watkins some confronting news.

"The saddest part was when the doctors advised me against having any more children because of my condition," she said.

Watkins said she was also shocked to be diagnosed with arthritis at the age of 28.

"I didn't actually think of it as arthritis, because when you think of arthritis you think of 80 year-old-men who are crippled with it.

"I didn't really put myself into that category."

Watkins, who is now 46, went on to have a successful surgery.

She also defied the odds by having another healthy child, who is now six years old.

While she still experiences some pain due to her osteoarthritis, Watkins said the symptoms had become manageable with the help of regular treatments with her osteopath.

Data from the 2021 Census shows that about 2.2 million Australians are now living with arthritis.

This makes arthritis the second-most common long-term health condition, after issues relating to mental health.

Almost one in five Aussies said their pain would have to be so bad that they were unable to move before seeking the help of a health professional.

Osteopathy Australia president Dr Michelle Funder said it was a misconception that having arthritis meant you had to suffer through severe pain.

"Although there is no cure for arthritis, osteopathy may help to reduce pain, ease swelling and improve mobility and range of joint movement," Funder said.

"Early diagnosis and improving a person's lifestyle are key to preventing further degeneration, and to help them perform daily activities more easily."

Contact reporter Emily McPherson at empcherson@nine.com.au.

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Tamara was just 28 when she was diagnosed with a condition affecting 2.2 million Australians - 9News

Arthritis causes pain, swelling and inflammation of one or multiple joints. Its not a single disease but an umbrella term used to refer to a wide array of conditions. Its one of the most widespread health conditions in the nation.

There are more than 100 types of arthritis, of which osteoarthritis is the most common. Osteoarthritis, also known as degenerative joint disease, occurs over time due to wear and tear of cartilage that protects the ends of the bones. Although osteoarthritis can damage any joint, the disorder most commonly affects joints in the hands, knees, hips and spine.

There are also inflammatory forms, such as rheumatoid arthritis; psoriatic arthritis; and the arthritis associated with ankylosing spondylitis, lupus and gout. In those cases, inflammation is caused by an overactive immune system that attacks connective tissues. (Learn more about autoinflammatory arthritis.)

In the United States, an estimated58.5 million individuals are gripped with arthritis the leading cause of disability. More than 50% of this population fall in the working age group (18 to 64 years).

Despite how common this condition is, there are several myths that persist, making it confusing for patients seeking to relieve their symptoms and to improve their quality of life. This article aims at debunking these long-held myths and getting your facts straight!

Fact:Arthritis is more common in older adults, but there are several types that can affect both children and young adults.

Juvenile idiopathic arthritis (also known as childhood arthritis or juvenile rheumatoid arthritis) is the most common type of arthritis among children and can cause permanent physical damage to joints. According to Cleveland Clinic, one in 1,000 children (or about 300,000 children in the U.S.) are affected.

Fact: There are many conditions such as tendonitis,bursitis and other soft-tissue injuries that cause joint pain and have a pain profile similar to that of arthritis. Hence, it is of utmost importance to get an accurate medical diagnosis, preferably by a rheumatologist, before treating any kind of joint pain.

Fact: False! Diagnosing and treating arthritis at its early stage not only can save your joints but also save you from damage to vital organs. Certain forms, such as rheumatoid arthritis, can damage skin, eyes, lungs, blood vessels, the brain and the heart. It is important to determine which type of arthritis you have right away, because treatment varies and starting the correct treatment can be the key to preventing permanent damage.

Fact: There currently isnt a cure for arthritis. However, treatment focuses on relieving symptoms and improving joint function. Working with an arthritis expert can help.

Depending upon the type of arthritis, certain medications can reduce pain and inflammation. Osteoarthritis often is treated with pain-reducing medications, physical activity, weight loss (if the person is overweight) and self-management education.(Learn more about treatment.) Inflammatory disorders are treated with disease-modifying antirheumatic drugs that suppress the immune system.

Heat and cold treatment and assistive devices, such as walkers, braces and gloves, also can help.

Fact: Exercise can help increase strength, motion and flexibility and reduce pain and swelling. Inactivity can cause the symptoms to worsen, thus increasing both pain and swelling. Before you enroll in any exercise program, it is also important to know what your limits are and what level of exercise you can benefit from.

Read more:
Debunking common myths about arthritis - ASBMB Today

New findings from the ongoing Drug Repurposing for Effective Alzheimers Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidences of Alzheimers disease and related dementias in people with cardiovascular disease. While the findings do not support the broad use of these drugs for treating Alzheimers and related dementias, the results may point to a promising precision-medicine approach in specific groups of people at risk for developing these diseases.

The research was published in JAMA Network Open and led by NIA scientists in collaboration with researchers at Harvard Medical School, Boston; Rutgers University, New Brunswick, New Jersey; and Johns Hopkins University School of Medicine, Baltimore.

Discovering new drug targets in Alzheimers and related dementias is crucial for meeting the enormous public health challenge of these diseases. Prior studies on whether approved rheumatoid arthritis drugs lower the risk of developing dementia have produced mixed results. The ongoing NIA DREAM study previously identified several FDA-approved drugs that are being tested as candidate treatments for Alzheimers and related dementias.

In this study, researchers analyzed data in Medicare claims from more than 22,000 people aged 65 years and older from 2007 to 2017, looking at whether those with rheumatoid arthritis who took one of three different classes of arthritis drugs were protected from dementia.

Researchers found that there were no statistically significant associations with lowered dementia risk except among those with cardiovascular disease who were treated with one class of arthritis drugs called TNF inhibitors. These inhibitors suppress the immune system by blocking the activity of TNF, which is a substance in the body that can cause inflammation and lead to immune-system diseases, including rheumatoid arthritis. Moreover, a recent large Genome-Wide Association Study (GWAS) discovered genetic risk variants related to TNF signaling to be associated with the risk of Alzheimers, suggesting that abnormalities in this pathway may be causally related to the disease. Together, these findings demonstrate the importance of generating valid, actionable evidence on drug repurposing using routine health care data.

An important limitation is that the development of Alzheimers and related dementias may begin many years before a clinical diagnosis. Given this, longer periods of treatment and/or observation may be needed to draw firmer conclusions about the null findings. Additionally, although the researchers strived to address limitations related to identifying Alzheimers and related dementias in health care claims through their careful study design, there remains a possibility of bias from outcome misclassification.

This research was supported by NIA Intramural Research Program project 1ZIAAG000436-01.

These activities relate to NIAs AD+ADRD Milestone 7.B, Initiate research programs for translational bioinformatics and network pharmacology to support rational drug repositioning and combination therapy from discovery through clinical development.

References: Desai R, et al. Comparative Risk of Alzheimer Disease and Related Dementia Among Medicare Beneficiaries With Rheumatoid Arthritis Treated With Targeted Diseases-Modifying Antirheumatic Agents. JAMA Network Open. 2022;5(4):e226567. doi:10.1001/jamanetworkopen.2022.6567.

See the original post:
Some arthritis drugs may reduce Alzheimer's and related dementias risk in those with heart disease - National Institute on Aging

Peng Thim Fan, MD, FACP, is a clinical professor of rheumatologyat David Geffen School of Medicine at UCLA. He also serves as a staff rheumatologist for VA Greater Los Angeles Health Care System.

During the first day of Pri-Med West 2022in Anaheim, Fan's presentation featured 3 case studies in rheumatic disease with the first focusing on osteoarthritis and the second on rheumatoid arthritis. The third case study falls on a different spectrum by examining a patient with a single swollen joint.

In an interview, he explained that infection is always a concern when a patient presents with monoarthritis. And with the COVID-19 pandemic, a new discussion on rheumatic diease and infection has surfacedone that is constantly evolving.

"There are some emerging studies showing that having an autoimmune background not only may make your illness worse, but that the risks of long COVID, the so-called long-haul syndrome, may actually be higher when you have autoimmune background and auto antibodies, and so on," Fan said.

While there are many uncertainties surrounding the novel coronavirus, the vaccine has offered substantial protection for patients with rheumatic disease, he said. Initially, there was concern regarding the effectiveness of the vaccine in this population because of the use of immunosuppressant treatments.

"People on immunosuppressive still able to mount a pretty good response to the vaccine and get protected," Fan said. "Interestingly, some of the drugs that we don't really think are important, happen to be important."

The example he gave was methotrexate, which isn't an immunosuppressant. However, people who take it should talk with their doctor about pausing use of the medication prior to receiving the vaccine because it can reduce the efficacy, Fan explained.

"We're starting to see some cases of reactive arthritis after COVID-19 infection and also after vaccination," he said. "So, that's something to watch out for. So, there is an evolving story."

Read the original:
Peng Thim Fan, MD: Reactive Arthritis and Long Covid-19 - MD Magazine

HAUPPAGE, N.Y.--(BUSINESS WIRE)--United Rheumatology, the pre-eminent rheumatology care management organization known for empowering rheumatologists to advance the standard of care across the country, today announces a new project with its longstanding partner, CreakyJoints, the international digital community for millions of arthritis patients and caregivers who seek education, support, advocacy, and patient-centered research. CreakyJoints is part of the non-profit Global Healthy Living Foundation. Together, the two organizations launched the Rheumatoid Arthritis Wellness Center to provide rheumatologists with a trusted place to refer patients for educational information and tools to incorporate into their rheumatoid arthritis (RA) management strategy post-appointment.

The Rheumatoid Arthritis Wellness Center digital resources were developed in consultation with health care professionals and the CreakyJoints patient community and overseen by the medical leadership of United Rheumatology. Key topics included in the wellness center include managing fatigue, sleep, exercise, and nutrition as well as recommendations for managing the overall mental and emotional aspects of living with a chronic disease. United Rheumatology and CreakyJoints will expand the center later this year to include related rheumatic conditions.

Our United Rheumatology rheumatologists understand that living with RA can be hard and coping with RA symptoms like pain and fatigue often requires more than just medication. Thats why we were inspired to collaborate with CreakyJoints to create a centralized, reliable resource for our patients that will start them on the path of understanding their disease and committing to lifelong management, said Dr. Andrew Concoff, Chief Medical Officer, United Rheumatology.

Too often after their rheumatology appointment, patients go home and then consult Dr. Google, to answer their questions, but that can be problematic. The Rheumatoid Arthritis Wellness Center allows our patient community to easily access trusted, patient-friendly information and resources and to connect with the arthritis community, added Dr. Concoff.

Finding Community and Support

The Rheumatoid Arthritis Wellness Center also directs people living with RA to places where they can find peer support, both online and in-person. CreakyJoints offers online support via multiple social media platforms and free access to the ArthritisPower Research Registry, which already includes more than 35,000 consented members who use the phone or desktop application to track their experience of symptoms, treatments, and complementary therapies with the added option of participating in voluntary research studies.

By working together, as a leading patient organization and a leading specialty care network, we are helping patients thrive before, during, and after their rheumatologist visits. Just as its unthinkable to travel somewhere new without GPS navigation, everyone living with RA needs a well-mapped wellness plan that can be personalized and centered around them. Thats exactly what this program was designed to do, said Seth Ginsberg, Co-founder and President of the Global Healthy Living Foundation and CreakyJoints.

Visit the Rheumatoid Arthritis Wellness Center today.

About CreakyJoints

CreakyJoints is an international digital community for millions of arthritis patients and caregivers who seek education, support, advocacy, and patient-centered research. We represent patients in English, Spanish, and French through our popular social media channels, our websites, and the 50-State Network, which includes more than 1,700 trained volunteer patient, caregiver, and provider health care activists.

Part of the Global Healthy Living Foundation, CreakyJoints also has a patient-reported outcomes registry called ArthritisPower (ArthritisPower.org), which includes tens of thousands of consented arthritis patients who track their disease while volunteering to participate in longitudinal and observational peer-reviewed research. In addition to online and downloadable educational resources, CreakyJoints publishes many arthritis and chronic disease podcast series, available on all major streaming platforms, that provide both patient and provider perspectives. It also hosts PainSpot (PainSpot.org), a digital risk-assessment tool for musculoskeletal conditions and injuries, and eRheum (eRheum.org), for telehealth and virtual-care support. All programming is free, always. For more information, visit CreakyJoints.org.

About United Rheumatology: United Rheumatology represents and supports over 650 community-based rheumatologists in 39 states. It does not own or operate rheumatology practices; the practices are all independent. The Company has established a comprehensive portfolio of physician, patient, and health plan payor offerings. Driven by the largest rheumatology electronic medical records clinical database in the U.S., United Rheumatology supports an unparalleled platform for jointly developed coordinated care solutions.

For more information visit https://unitedrheumatology.com/.Or follow us on LinkedIn, Twitter, or Facebook.

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United Rheumatology and CreakyJoints Launch the Rheumatoid Arthritis Wellness Center - Business Wire

An ad hoc committee has been appointed to undertake a routine review of the UNC Thurston Arthritis Research Center and the leadership of Director Richard F. Loeser, Jr., MD, and Joseph P. Archie, Jr., Eminent Professor of Medicine. The review is a standard procedure of the University of North Carolina at Chapel Hill and will take place on June 21, 2022.

An ad hoc committee has been appointed to undertake a routine review of the UNC Thurston Arthritis Research Center and the leadership of Director Richard F. Loeser, Jr., MD, and Joseph P. Archie, Jr., Eminent Professor of Medicine.

The review is a standard procedure of the University of North Carolina at Chapel Hill and will take place on June 21, 2022.

The review committee invites your participation and input:

The deadline to request time on the review committee agenda, or to share written comments, is June 10, 2022.

Note that North Carolina law requires that any written materials developed or received by the committee during the review may be made available to the person reviewed upon request. All requests from the person reviewed will be handled by the Legal Department and any identifying information will be redacted prior to release of the material.

Members of the Review Committee

Mark Zylka, PhD Review Committee Chair, Distinguished Professor, Cell Biology and Physiology

Deborah Givens, PT, DPT, PhD, FAPTA Distinguished Professor, Department of Allied Sciences, Division of Physical Therapy

Corrine Keet, MD, PhD Professor, Department of Pediatrics, Division of Pediatric Allergy and Immunology

Yisong Wan, PhD Professor, Department of Microbiology & Immunology

Roland Tisch, PhD Professor, Department of Microbiology & Immunology

Shannelle Campbell, MD, MPH, FACS Assistant Professor, Department of Surgery

Adesola Akinkuotu, MD Assistant Professor, Department of Medicine, Division of Pediatric Surgery

James Sanders, MD Distinguished Professor, Chair, Department of Orthopaedic Surgery

Read the original:
Five-Year Review of UNC Thurston Arthritis Research Center, Loeser and Archie | Newsroom - UNC Health and UNC School of Medicine

ReportLinker

Global Rheumatoid Arthritis Drugs Market 2022-2026 The analyst has been monitoring the rheumatoid arthritis drugs market and it is poised to grow by $ 14. 90 bn during 2022-2026, accelerating at a CAGR of 7.

New York, May 03, 2022 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Rheumatoid Arthritis Drugs Market 2022-2026" - https://www.reportlinker.com/p05638948/?utm_source=GNW 73% during the forecast period. Our report on the rheumatoid arthritis drugs market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by unmet needs for safer biologics for RA, the availability of improved diagnostic modalities, and the need for affordable biologics for RA.The rheumatoid arthritis drugs market analysis includes the type segment and geographic landscape.

The rheumatoid arthritis drugs market is segmented as below:By Type Biologics Small molecules

By Geography Europe North America Asia Rest of World (ROW)

This study identifies the high cost of RA drugs as one of the prime reasons driving the rheumatoid arthritis drugs market growth during the next few years. Also, the use of biologics/biosimilars for the treatment of RA and the use of gene therapy for RA treatment will lead to sizable demand in the market.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters. Our report on rheumatoid arthritis drugs market covers the following areas: Rheumatoid arthritis drugs market sizing Rheumatoid arthritis drugs market forecast Rheumatoid arthritis drugs market industry analysis

This robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading rheumatoid arthritis drugs market vendors that include AbbVie Inc., Amgen Inc., Astellas Pharma Inc., Bristol Myers Squibb Co., Cyxone AB, Eli Lilly and Co., F. Hoffmann La Roche Ltd., Galmed Pharmaceuticals Ltd., Genor BioPharma Holding Ltd., Gilead Sciences Inc., GlaxoSmithKline Plc, Johnson and Johnson, Kangstem Biotech Co. Ltd., Novartis AG, Oryn Therapeutics, Pfizer Inc., Sanofi, Sorrento Therapeutics Inc., Taisho Pharmaceutical Holdings Co. Ltd., and UCB SA. Also, the rheumatoid arthritis drugs market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage all forthcoming growth opportunities.The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.

The analyst presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters such as profit, pricing, competition, and promotions. It presents various market facets by identifying the key industry influencers. The data presented is comprehensive, reliable, and a result of extensive research - both primary and secondary. Technavios market research reports provide a complete competitive landscape and an in-depth vendor selection methodology and analysis using qualitative and quantitative research to forecast the accurate market growth.Read the full report: https://www.reportlinker.com/p05638948/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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The Global Rheumatoid Arthritis Drugs Market is expected to grow by $ 14.90 bn during 2022-2026, accelerating at a CAGR of 7.73% during the forecast...

Pain in the big toe may be more common than you think. The big toe is the area of the foot most commonly affected by arthritis, which is a common source of pain and stiffness in a joint.

We end up seeing it frequently, said Dr. Alejandro Miranda, an orthopedic surgeon in Steamboat Springs and a member of the medical staff at UCHealth Yampa Valley Medical Center. Arthritis technically means joint inflammation or pain, but we often think of it as wear and tear of the joint surface. In the big toe, it is medically diagnosed as hallux rigidus.

Since that wear and tear happens naturally over time, arthritis of the big toe usually impacts older patients. But younger patients arent immune, as the issue can be brought on by trauma or stress to the joint, and genetics.

Not too uncommonly we will see people in their 30s present with arthritis of the big toe, Miranda said. It may be that they were more susceptible or that they somehow traumatized that joint.

Symptoms include pain, stiffness and swelling.

In the early stages, people may feel their footwear applies more pressure than it used to. As the joint stiffens, mobility lessens and it becomes harder to put on boots or shoes, Miranda said. Another early sign is pain with physical activity.

Initial treatment options include wearing spacious shoes to accommodate the enlarged joint and using stiffer shoes or insoles. Taping techniques can also be used so the affected joint doesnt have as much range of motion.

Youre more or less splinting the injured joint, and because of that, a lot of people will feel some relief, Miranda said.

Oral and topical anti-inflammatories, as well as physical therapy, may also help with pain.

Exercises that heavily load the toe, such as weighted lunges and burpees, may exacerbate the issue, so Miranda encourages patients to tailor their workouts accordingly.

If those initial efforts dont help, a steroid injection in the toe, done under X-ray guidance to ensure the steroid gets into the joint, can help quiet down the joint space and alleviate pain. But eventually, surgery may be considered if nonoperative treatments fail.

Once conservative treatments stop taking effect and as the pain becomes more limiting, we start thinking about surgical options, Miranda said. The goal is always to find whats right for each individual to get them back to doing what they like to do.

In general, three types of surgery may be considered: bone spurs that impinge the joint and cause pain can be shaved away; synthetic implants or tissue can be interposed in the joint to restore joint spacing; and finally, the joint can be fused.

Fusing the joint converts a diseased and painful stiff joint into a painless stiff joint, Miranda said. For the person who has debilitating pain and symptoms in which their joint is stiffened already, youre helping them by making it painless.

Patients may worry that fusing the joint will make it harder to return to activities, but in fact, people are still able to hike, run, ski and do labor-intensive jobs.

Certainly, some modifications need to be made some people end up selecting different footwear or different types of boots but most people do get back to most of their activities without pain, Miranda said.

Miranda encourages people who are having pain and stiffness in the big toe to seek an evaluation.

Arthritis is only one of the diagnoses that causes pain in the toe. Seeking an evaluation can shed light on the source of pain, and help determine next steps are for pain relief, Miranda said.

Susan Cunningham writes for UCHealth Yampa Valley Medical Center. She can be reached at cunninghamsbc@gmail.com.

Link:
Monday Medical: Addressing arthritis of the big toe - Steamboat Pilot & Today

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Machine learning-based prediction of relapse in rheumatoid arthritis patients using data on ultrasound examination and blood test | Scientific Reports...