StemCell Therapy

Welcome to your weekly roundup of approaching clinical readouts.Pfizers Jak 1 inhibitor abrocitinibwill need to prove itself against the dermatitis stalwart Dupixent in the phase III Jade-Compare trial, data from which aredue shortly. It is already known that abrocitinib works in atopic dermatitis, sinceit met key endpoints in two phase III trials. But the safety profile will need to beclosely analysed; Jak inhibitors have had to contend with serious toxicities when used in rheumatoid arthritis.

Abrocitinib is said to be selective for Jak 1, which investigators believe reduces the risk of class-related adverse events such as infections and thromboembolic and other cardiovascular events.

In abrocitinibs previous atopic dermatitis studies,Jade Mono-1 and 2, the rate of serious adverse events was 2-3% in treated patients, anddiscontinuations were in the 4-6% range, higher than the 2% previously seen with Dupixent. There were no thromboembolic events with Pfizers Jak, but there seem to be tolerability issues judging by the 10-20% rate of nausea and headache. In Dupixent studies the most frequent adverse eventswere injection site reactions and conjunctivitis.

In terms of efficacy the higher dose of abrocitinib showed comparable results to Dupixent in its pivotal trials. In the latest study, Jade-Compare, abrocitinib is pitted directly against Dupixent in adults on topical background therapy. Again 100mg and 200mg daily doses of abrocitinib are being tested, and the co-primary endpoints are investigators global assessmentand EASI-75 score at 12 weeks.

On Pfizers third-quarter call management specifically pointed to a secondary endpoint, pruritus reduction, where the company expects abrocitinib to outperform, as it inhibits the interleukin-31 that is a major itch mediator, which is not covered by Dupixent.

Displacing Dupixent will be tough given physicians' experience and the potential for a black-box warningfor abrocitinib, in common with other Jaks. OnPfizers side will be convenience: abrocitinib is oral and Dupixentsubcutaneous.

In terms of Jak competition Lillys Olumiant and Abbvies Rinvoq are in phase III trials in atopic dermatitis and approved,with black box warnings, in rheumatoid arthritis. Meanwhile, Dermira has just been bought by Lilly (Lilly jumps the gun with Dermira deal, 10 Jan 2020).

Myovant looks for Spirit guidance

For Myovant Sciences phase III endometriosis data due by the end ofthe second quarter will not just be about scoring a clinical win with its GnRH inhibitor relugolix; they will alsohopefully showsome benefit over the approved market leader, Abbvies Orilissa.

Relugolix has previously disappointed relative to expectations in cross-trial comparisons with Orilissa in uterine fibroids. And on its current development trajectory, even if the Spirit 1 and Spirit 2 trials are successful, the project will hit the market two and a half years after Orilissa. Strong data will be essential if Myovant is to stand any chance of taking market share from the pharma giant.

Relugolix and Orilissa both work by blocking the gonadotrophin hormone and reducing the pain associated with endometriosis, a disorder where tissues that usually line the wall of the uterus grow outside of the womb.

However, where Orilissa is used asa monotherapy, the Spirit trials are testing relugolix in combination withan oestrogen"add-back therapy". One of the biggest side effects of GnRH antagonists isbone loss, whichcan limit the duration of treatment. Add-back therapy can thus extend the treatment window for what is a chronic disease.

Myovant supporters have highlighted this as an advantage over Orilissa, alongside relugolixs dosing convenience. But Abbvie could hobble this advantage with results from a 681-patienttrialcomparing Orlissa monotherapy against a combination with hormoneadd-back. If thistrial is positive Leerink analysts say alabel extension for Orilissa could follow in the third quarter, six months beforerelugolixs forecast endometriosis approval.

With so much stacked up against Myovant it is not surprising that 2024 sales forecasts for relugolix in endometriosis are only $278m, compared with $843m for Orilissa, according to EvaluatePharma. The Spirit data will have tosurprise for Myovantto avoidbeing an also-ran in the indication.

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Upcoming events Pfizer's abrocitinib and Myovant's relugolix - Vantage

Prolotherapy is the use of a solution that helps grow stronger ligaments and tendons. Arthritis is considered a joint problem but the pain from arthritis is often caused by the surrounding soft tissue, which consists of these ligaments and tendons. Because of this, prolotherapy is a great treatment for a wide range of arthritic conditions. If you have arthritis, you have the opportunity to greatly benefit from prolotherapy.

Ligaments hold together bones. Around a joint they blend together to form a joint capsule. Tendons are said to connect muscles to bones, but it is more accurate to say that tendons are the continuation of the muscles that help connect the muscles to bones. This connection helps the muscles move the bones. The problem for both ligaments and tendons is that they do not get much blood flow. The difference in blood flow between the muscles and tendons and ligaments is highlighted by their color differences. Muscles are red with good blood flow, while ligaments and tendons are yellow-white, suggesting poor blood flow. So when they are injured, ligaments and tendons do not heal well. This contrasts with muscle which, when injured, tends to heal very well, often in four to six weeks.

Joint arthritis is thought of as the wearing out of bones that are connected. A common example is the knee joint. An x-ray of knee arthritis shows that the bones are closer together, called joint space narrowing (or on the spine, called disc space narrowing). Also seen on x-rays are bone spurs that grow off the bone. What is not well visualized on x-ray are ligaments and tendons. It is important to understand that loosening of ligaments plays a key role in the development of arthritis. Also, much of the arthritic pain is from the ligaments and tendons around the joint. By strengthening the ligaments and tendons with the prolotherapy solution, the arthritic pain can dramatically improve. Even when knee arthritis is severe, as in bone-on-bone, the pain can improve with prolotherapy. That is because much of the pain is coming from the ligaments and tendons, and even with severe arthritis the tendons and ligaments respond well to prolotherapy.

As a general rule, bone spurs result from loose ligaments. When a ligament is loose, the joint has intrinsic instability. Sometimes the instability is severe that the joint slips out of place. More often, there is mild laxity (looseness) such that the bones mildly rub against one another. In reaction to this physical stress, bone spurs develop as a way for the bone to protect itself. While the bone spur can cause some stiffness with movement, it usually does not cause pain. However, the unhealthy ligaments can cause significant pain. By improving the strength of the ligament, the joint pain will subside. When joint movement is affected by arthritis, the tendons also bear stress with the abnormal movement. These weakened tendons also produce pain. When the tendons are strengthened, the pain is significantly improved.

The shoulder is the most mobile joint in the body, so it is susceptible to arthritis. While they are considered different conditions, rotator cuff tendonitis and shoulder arthritis result from a similar cause. The rotator cuff is a group of four muscles that wrap around the shoulder like a cuff. By its name you can guess that the rotator cuff helps rotate the shoulder. Just as important, the cuff helps stabilize the shoulder, helps keep the shoulder joint in place when the arm is moving. When the ligaments weaken, this puts stress on the shoulder joint so bone spurs form and arthritis develops. At the same time, when the ligaments weaken, the rotator cuff muscles have to work harder. The cuff muscles then become strained, eventually progressing to a tear. Thus, rotator cuff injuries and arthritis form as part of this process. The good news is that because both problems involve ligament laxity and weak tendons, both conditions respond very well to prolotherapy.

Hips and knees are the key weight bearing joints so they are also vulnerable to arthritis. By strengthening the ligaments and tendons around knees and hips, the pain improves. Hands include our most used joints so they are also very susceptible to arthritis. Because they get so much use, the finger joints become stiff, painful and even deformed. While prolotherapy will not necessarily reverse the deformity, arthritic hand pain responds beautifully to prolotherapy. This is because the hand pain is caused by very small tender ligaments which are strengthened by prolotherapy.

While arthritis in the spine has different names including stenosis, spondylosis, facet syndrome and degenerative disc disease, they all have a similar underlying cause: lax ligaments. Even disc herniations are related to lax ligaments. Discs are sandwiched by the vertebrae (spine bones) and are made of fibrous tissue with a central gel-like substance. When the ligaments weaken, the vertebrae lose their support. This increases disc pressure, so the disc fibers weaken, eventually herniating or falling out. When the disc compresses the nerve, severe leg pain results, otherwise known as sciatica. As the discs wear out, the space between the vertebrae narrows, with bone spurs forming. This leads to the typical arthritic spine pain, known by the various names described above. This process is similar in the cervical spine (neck) and lumbar spine (low back). The key to understanding this is that it is lax ligaments which are a strong contributor to all these conditions. This is why prolotherapy is so effective for neck and back pain conditions.

Another key aspect of prolotherapy that complements its effectiveness is that it is very safe. As opposed to a steroid injection, which suppresses body functions and has to be limited due its toxicity, prolotherapy stimulates the bodys healing reactions so it can be repeated, if necessary, and can be used for multiple areas of pain. As opposed to arthroscopy, which treats arthritic pain by cutting away loose tissue fragments and bone spurs, prolotherapy treats arthritic pain by building and strengthening tissue for long-term healing.

In summary, prolotherapy is a great treatment for arthritis affecting multiple joints, including the most commonly affected joints such as the shoulders, hips, knees and fingers, and even less commonly affected joints such as the elbows, wrists, ankles and toes, and also anywhere along the spine including the neck and low back. The reason it is so effective for arthritis is because the pain caused by arthritis is often caused by lax ligaments and these ligaments are strengthened by prolotherapy. Please check my website where I describe the logistics of prolotherapy (Prolotherapy Info) and go into more detail about how prolotherapy works (How Prolotherapy Works).

Dr. Slaten is a pain wellness physician in Ridgewood. For more than 20 years, he has been practicing with great skill and an open mind. Learn more about prolotherapy and his other treatments at his website, http://www.njprolo.com.

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Prolotherapy Is a Great Treatment for Arthritis - Jewish Link of New Jersey

The report titled Global Psoriatic Arthritis Treatment Market Size, Status and Forecast 2019-2025 provide (6 Year Forecast 2019-2025)enhanced on worldwide competition by topmost prime companies (Eli Lilly, Roche, Merck, Novartis, Abbvie, Amgen, Bristol Myers Squibb, Celgene Corporation, Janssen, Valeant Pharmaceuticals) which providing information such asCompany Profiles, Capacity, Gross, Gross Margin, Product Picture and Specification, Production, Price, Cost, Revenueand contact information. This Psoriatic Arthritis Treatment market report crucial insights that facilitate theMarket Trends, Drivers, Market Dynamics, Overview, Scope, Definitions, Classifications, Opportunities, Competitive Landscape. The report provides key statistics on the market status of the Psoriatic Arthritis Treatment market manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.

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Psoriatic Arthritis Treatment Market Advance Technology And New Innovations 2020 To 2025 -Eli Lilly, Roche, Merck, Novartis - Market Research Sheets

While most polar bears live only to their mid-20s, Boris recently celebrated his 34th birthday, meaning hes probably the oldest male polar bear on the planet, and hes living out his best retirement years at Point Defiance Zoo & Aquarium after living treacherously with a traveling circus.

At 11:01 a.m. on an unseasonably warm morning, Point Defiance Zoo & Aquarium staff biologist Cindy Roberts exited the backstage area of the zoos polar bear exhibit and arrived moments later in the public viewing area for her two furry, white charges.

My name is Cindy, Im a staff biologist, and Im lucky enough to work with our two polar bears, Roberts said with an energetic smile as she addressed the families that had accumulated in front of the exhibit.

We have Blizzard, who is our younger bear; he is going to be 24 years old, Roberts continued. And we also have Boris, who is our really old bear; he (turned) 34 on Dec. 15th.

Blizzard was standing just beyond the exhibits saltwater pool. Elsewhere, hidden from the view of the crowd, Boris lounged indoors with his hind legs spread straight out behind him as he laid on the floor and pawed languidly at an ice treat fillets of salmon in a block of ice in front of him.

The 873-pound-bear is perfectly content, and despite some common elderly issues skin and liver problems, arthritis, and bad teeth from years of mistreatment hes living a happy, healthy life.

Prior to coming to Point Defiance in the early aughts, Boris lived a storied life with two circus productions. He was born in a German zoo in the mid-1980s, and at 18 months old, started performing with Ursula Bttcher, one of the most celebrated female animal trainers in the world, who was particularly famous for performances with polar bears.

She took care of those bears very well for that time period, Roberts said of the research shed done on Bttcher and her act. If she thought anyone was harming them in any way, she would fire them instantly.

However, after the fall of the Berlin Wall and the unification of Germany in 1989, the state-run East German circus that effectively owned Boris began to be phased out, and by the late 1990s, the bears had been sold. Some remained in Europe, but most were sold to the Suarez Brothers Circus in Mexico.

The Suarez Brothers badly mistreated the bears, feeding them a feeble diet of bread and lettuce and housing them in small cages without room to swim or cool off. The bears were eventually seized by American authorities after the zoo traveled to Puerto Rico a U.S. territory.

A YouTube video taken around the time of the bears seizure shows the massive mammals crammed into small cages atop a trailer. The bears were panting, drooling, and swaying side to side in an attempt to cool themselves.

Our vet at the time, Dr. Holly Reed she has since passed away she actually transported the bears to the U.S., and they were in pretty bad shape, Roberts said. We got Boris and Kenny the other bears went to Baltimore, Detroit, and North Carolina.

Though Roberts was not at the zoo when Boris arrived, she has now worked with him for more than a decade, and he holds a special place in her heart.

Hes just an amazing animal because of his history, she said. I think not only does (his story) give us all passion for polar bears in general, but it gives us hope in facing challenges and getting to the other side where you get salmon treats and you dont have to go outside.

Born: Dec. 15, 1985

Weight: 873 pounds

Height: 5 feet

Diet: Raw ground meat, fish, beef fat, and specially formulated kibble

Pounds of food per day: 7.5 to 21

Medication: 134 pills a day

Fun fact: He was the first polar bear to receive a stem cell transplant, to help lessen the effects of his arthritis.

Save the date

Interested in learning about how to help polar bears like Boris live long, healthy lives? Consider attending the zoos annual Party for Polar Bears, presented by the Point Defiance Chapter of the American Association of Zookeepers from 5 to 9 p.m. on Feb. 24, at Dystopian State Brewing in Tacoma. More information here.

Originally posted here:
The Oldest Polar Bear in the World Likely Lives in Tacoma - 425magazine.com

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Development and validation of a clinical rule for recognition of early inflammatory arthritis.

BMJ Open. 2019 02 22;8(11):e023552

Authors: Ten Brinck RM, van Dijk BT, van Steenbergen HW, le Cessie S, Numans ME, Hider SL, Mallen C, van der Helm-van Mil A

AbstractOBJECTIVES: National and international guidelines recommend prompt referral of patients presenting with inflammatory arthritis (IA), but general practitioners (GPs) feel uncertain in their proficiency to detect synovitis through joint examination, the method of choice to identify IA. Our objective was to develop and validate a rule composed of clinical characteristics to assist GPs and other physicians in identifying IA when in doubt.DESIGN: Split-sample derivation and validation study.SETTING: The Leiden Early Arthritis Recognition Clinic (EARC), a screening clinic for patients in whom GPs suspected but were unsure of the presence of IA.PARTICIPANTS: 1288 consecutive patients visiting the EARC.PRIMARY AND SECONDARY OUTCOME MEASURES: Associations of clinical characteristics with presence of IA were determined using logistic regression in 644 patients, while validating the results in the other 644 patients (split-sample validation). To facilitate application in clinical practice, a simplified rule (with scores ranging from 0 to 7.5) was derived and validated.RESULTS: IA was identified by a rheumatologist in 41% of patients. In univariable analysis, male gender, age 60 years, symptom duration <6 weeks, morning stiffness >60min, a low number of painful joints (1-3 joints), presence of patient-reported joint swelling and difficulty with making a fist were associated with IA in the derivation data set. Using multivariable analysis, a simplified rule consisting of these seven items was derived and validated, yielding an area under the receiver operator characteristic curve (AUC) of 0.74 (95% CI 0.70 to 0.78) in the derivation data set. Validation yielded an AUC of 0.71 (95% CI 0.67 to 0.75). Finally, the model was repeated to study predicted probabilities with a lower prevalence of inflammatory arthritis to simulate performance in primary care settings.CONCLUSIONS: Our rule, composed of clinical parameters, had reasonable discriminative ability for IA and could assist physicians in decision-making in patients with suspected IA, increasing appropriateness of healthcare utilisation.

PMID: 30798292 [PubMed indexed for MEDLINE]

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Development and validation of a clinical rule for recognition of early inflammatory arthritis. - DocWire News

Few people know that the seasonal SARS hides more dangers than it seems. Incorrect or incomplete treatment of the common cold can affect the human body severe pain with every movement because of the infection of the joints.

Getting arthritis or gout possible due to seasonal and SARS, which often suffer from fall and winter. The common cold will develop into pain and deformity of the joints, if you just ignore it or MIS treated. Its all in the bloodstream, which carries the infection throughout the body from the affected areas. Weakened by the struggle with a cold, the immune system literally can miss the infection of the joints, especially if the person recently stood in the cold or got hypothermia.

To lose joints possible not only after you sneeze or cough, but promiscuous sex and urinary tract infection. The infection acts on the same principle that SARS travels through the bloodstream and infects cartilage, bringing the man down. Such rogue infection develops reactive arthritis, a dangerous disease that is very difficult to diagnose.

Under threat and people in the reverse situation, when the immune system is working at 120% because of the medicine. He can be overzealous after the suppression of the disease, and begin to attack the cartilage of joints, causing rheumatoid arthritis. The disease quickly immobilizes a joint and switched on the nearby tissue, which is extremely dangerous.

The main danger of such a receiving arthritis in that it is extremely difficult to diagnose and successfully cure it is possible only at the initial stage (both diseases). Because doctors do not advise to delay going to the hospital, or instead of therapy and pills, the patient will have to lie on the operating table and undergo a long rehabilitation.

Maria Batterburyis a general assignment reporter at the Saxon. She has covered sports, entertainment and many other beats in her journalism career, and has lived in Manhattan for more than 8 years. Vivian has appeared periodically on national television shows and has been published in (among others) NPR, Politico, The Atlantic, Harpers, Wired.com, Vice and Salon.com..

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SARS can cause arthritis and gout - The Saxon

Oregon State University research has provided the first complete, cellular-level look at whats going on in joints afflicted by osteoarthritis, a debilitating and costly condition that affects nearly one-quarter of adults in the United States.

The study, published in Nature Biomedical Engineering, opens the door to better understanding how interventions such as diet, drugs and exercise affect a joints cells, which is important because cells do the work of developing, maintaining and repairing tissue.

Research by the OSU College of Engineerings Brian Bay and scientists from the Royal Veterinary College in London and University College London developed a sophisticated scanning technique to view the loaded joints of arthritic and healthy mice loaded means under strain, such as an ankle, knee or elbow would be while running, walking, throwing, etc.

Imaging techniques for quantifying changes in arthritic joints have been constrained by a number of factors, said Bay, associate professor of mechanical engineering. Restrictions on sample size and the length of scanning time are two of them, and the level of radiation used in some of the techniques ultimately damages or destroys the samples being scanned. Nanoscale resolution of intact, loaded joints had been considered unattainable.

Bay and a collaboration that also included scientists from 3Dmagination Ltd (UK), Edinburgh Napier University, the University of Manchester, the Research Complex at Harwell and the Diamond Light Source developed a way to conduct nanoscale imaging of complete bones and whole joints under precisely controlled loads.

To do that, they had to enhance resolution without compromising the field of view; reduce total radiation exposure to preserve tissue mechanics; and prevent movement during scanning.

With low-dose pink-beam synchrotron X-ray tomography, and mechanical loading with nanometric precision, we could simultaneously measure the structural organization and functional response of the tissues, Bay said. That means we can look at joints from the tissue layers down to the cellular level, with a large field of view and high resolution, without having to cut out samples.

Two features of the study make it particularly helpful in advancing the study of osteoarthritis, he said.

Using intact bones and joints means all of the functional aspects of the complex tissue layering are preserved, Bay said. And the small size of the mouse bones leads to imaging that is on the scale of the cells that develop, maintain and repair the tissues.

Osteoarthritis, the degeneration of joints, affects more than 50 million American adults, according to the Centers for Disease Control and Prevention. Women are affected at nearly a 25 percent rate, while 18 percent of men suffer from osteoarthritis.

As baby boomers continue to swell the ranks of the U.S. senior population, the prevalence of arthritis will likely increase in the coming decades, according to the CDC.

The CDC forecasts that by 2040 there will be 78 million arthritis patients, more than one-quarter of the projected total adult population; two-thirds of those with arthritis are expected to be women. Also by 2040, more than 34 million adults in the U.S. will have activity limitations due to arthritis.

Osteoarthritis will affect most of us during our lifetimes, many to the point where a knee joint or hip joint requires replacement with a costly and difficult surgery after enduring years of disability and pain, Bay said. Damage to the cartilage surfaces is associated with failure of the joint, but that damage only becomes obvious very late in the disease process, and cartilage is just the outermost layer in a complex assembly of tissues that lie deep below the surface.

Those deep tissue layers are where early changes occur as osteoarthritis develops, he said, but their basic biomechanical function and the significance of the changes are not well understood.

That has greatly hampered knowing the basic disease process and the evaluation of potential therapies to interrupt the long, uncomfortable path to joint replacement, Bay said.

Bay first demonstrated the tissue strain measurement technique 20 years ago, and it is growing in prominence as imaging has improved. Related work is being conducted for intervertebral discs and other tissues with high rates of degeneration.

This study for the first time connects measures of tissue mechanics and the arrangement of the tissues themselves at the cellular level, Bay said. This is a significant advance as methods for interrupting the osteoarthritis process will likely involve controlling cellular activity. Its a breakthrough in linking the clinical problem of joint failure with the most basic biological mechanisms involved in maintaining joint health."

The Engineering and Physical Sciences Research Council, Arthritis Research UK, the Medical Research Council, and the Diamond-Manchester Branchline at Diamond Light Source supported this research.

Continued here:
To Your Health: Study paves way to better understanding, treatment of arthritis - The Chief News

KEY POINTS

Arthritis is a catch-all term for a series of painful conditions that cause tenderness and swelling of one or more joints.Rheumatoid arthritis and osteoarthritis are two of the most common types of arthritis.

The Joints Affected

Osteoarthritis usually affects the knees, spine, hips, and hands. Rheumatoid arthritis, on the other hand, oftentimes affects the wrists, hands, and feet.

While there is no cure for this painful condition, there are some lifestyle interventions that have been proven to alleviate the symptoms. Among these is consuming a well-known Christmas treat. gingerbread treatment for arthritis Photo: NickyPe - Pixabay

A Delicious Treatment

A key ingredient of the gingerbread man can help alleviate arthritis symptoms. Several studies have shown ginger extract helps a lot in alleviating joint pains caused by arthritis.

One prominent research revealed that ginger extract has the same efficacy as ibuprofen in the first treatment period. Another study also found that Echinacea and ginger supplements can reduce pain and inflammation after knee surgery. Echinacea is a well-known herb that is often taken to treat colds and flu.Researchers also discovered that highly concentrated doses of ginger extracts are very effective for the treatment of osteoarthritis of the knee.

The Study

The research involved volunteers who are experiencing moderate-to-severe knee pain. After taking ginger extracts, the volunteers said they felt lesser pain in their knees upon standing and after walking.

An animal study also revealed ginger could help relieve joint pains caused by rheumatoid arthritis. The findings of the researchers were further strengthened by another research which found ginger to be very effective in relieving human muscle pain due to an exercise-induced injury.

Volunteers who ingested at least two grams of raw or heated ginger reported the pain they felt somewhat lessened. The inflammation was also reduced. The volunteers applied ginger extract three times a day for twelve weeks, and during this time, they report having reduced levels of pain.

Researchers say that, while raw and heated gingers are equally helpful in alleviating joint pains, heat-treated ginger is believed to have a stronger effect. The studys findings also suggest applying a ginger-laced gel or cream directly to the affected area can also alleviate the painful symptoms.In many studies, researchers say ginger extracts can greatly improve osteoarthritis in the knees when it is applied topically.

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Relieve Joint Pains Caused By Arthritis This Christmas By Having This Treat - International Business Times

DEAR DR. ROACH: Are you aware of the possibility of pancreatitis resulting from long-term vitamin D2 supplementation? I was diagnosed with IPMN with chronic pancreatitis after being on 50,000 IU of vitamin D2 once a week for nine months. I had mild upper left quadrant pain, which I am told is quite unusual for pancreatic cysts. After doing some research, I decided to decrease and then stop the D2. As I did, cyst sizes and tumor markers both decreased. In addition, the pain resolved. I was fortunate enough to detect the connection, but have not had any interest from medical practitioners about looking into the possible link here. J.D.

ANSWER: This is a complex issue, and it starts with your IPMN, which stands for intraductal papillary mucinous neoplasms of the pancreas. These are tumors of the pancreas that are at risk for becoming cancerous.

The size is the biggest predictor of malignancy, so your doctors are likely monitoring the size of your tumors. Those less than 2 cm in size are at low risk for malignancy. Malignant and cancerous are synonymous terms, but the boundary between benign tumors and malignant ones is not as sharp a line as we used to think.

These cystic tumors are filled with mucin and can block the main pancreatic duct or a side pancreatic duct, through which the pancreatic enzymes that help to digest food flow into the small intestine. Insulin is also produced by the pancreas, but it is transported to the body through the splenic vein into the liver rather than the ducts into the intestine. Blockage of the ducts causes ductal dilation behind the obstruction. For the subset in whom the pancreatic ducts get blocked, IPMN can also cause inflammation of the pancreas, called pancreatitis.

Scientists observed that vitamin D levels D2 and D3, the usual kind we supplement are low in people with any kind of pancreatitis, but vitamin D treatment often made the pancreatitis worse. This seeming paradox was resolved when it was further found that the inflammatory cells in the inflamed pancreas were making the active form of vitamin D (1,25-dihydroxy vitamin D), and high levels of this active D vitamin were increasing calcium levels. The increase made pancreatitis worse. The low levels of circulating vitamin D2 and D3 are part of the bodys response to the elevated 1,25-dihydroxy vitamin D. Vitamin D supplementation is thus not usually done in pancreatitis since it can make it worse.

With the lessening of inflammation because you stopped the D2, its possible the cysts decreased in size and the ducts were able to go back toward normal, relieving inflammation in your case of IPMN.

DEAR DR. ROACH: I have just been diagnosed with a Bakers cyst behind my knee but received little information about it. Can you please tell me causes and cures? D.O.

ANSWER: A Bakers cyst is a common problem. It is a fluid collection behind the knee. In adults, these are usually due to increased joint fluid (from arthritis, a meniscal tear or trauma) communicating with the back of the knee through a one-way valve.

They are treated by addressing the underlying problem; for instance, anti-inflammatories and moderate exercise for arthritis. In addition, an injection of an anti-inflammatory into the joint space is usually successful in relieving symptoms. If a person is resistant to these treatments, an orthopedic surgeon has particular expertise in managing these.

Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. Readers may email questions to ToYourGoodHealth@med.cornell.edu or send mail to 628 Virginia Dr., Orlando, FL 32803.

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Vitamin D's odd connection with pancreas inflammation - Marshall News Messenger

U.S. Rep. Debbie Dingell (D-12th District) voted in favor of H.R. 3, the Elijah E. Cummings Lower Drugs Costs Now Act. This landmark legislation will give Medicare the power to negotiate directly with the drug companies to lower the cost of prescription drugs for Medicare beneficiaries and Michiganders with private insurance.

Too many hardworking men and women face the terrifying high costs for prescription drugs and seniors dont have coverage for dental, vision, or hearing services, said Dingell. The House is delivering on the first step to lower prescription drug prices for the people. Since coming to Congress, I have led the fight to get Medicare to cover hearing aids and service. The eyes, ears, and teeth are just as much a part of healthcare. This bill invests savings from prescription drugs right back into expanding Medicare benefits to include dental, vision, and hearing.

Making hearing aids more affordable has been a priority for Dingell since coming to Congress. The first bill she ever introduced was the Medicare Hearing Aid Coverage Act to cover hearing aids for beneficiaries. Similar legislation passed the Energy and Commerce Committee this fall.

Right now, drug prices in the US are nearly four times higher than the combined average of 11 other similar countries, and Americans pay as much as 67 times more than consumers in other nations for prescription drugs.

Through allowing Medicare to directly negotiate the cost of prescription drugs, H.R. 3 will save patients and seniors $120 billion, and reinvest have a trillion dollars in expanding Medicare benefits to cover dental, vision, and hearing services, programs to address the opioid crisis, and research for new cures and treatments.

Diabetes About 9.8 percent of Michigan 864,882 people - are living with diabetes. For the most commonly used insulin medications, Michigan residents spend anywhere from $1,200 to $20,000 annually.

Under H.R. 3, Michigan residents could spend 3.5 times less on insulin. H.R. 3 can lower the average total cost of the insulin NovoLOG Flexpen by 76% from about $19,800 to $4,800 per year. Under H.R. 3, some commonly used insulins can cost as little as $400 per year.

Arthritis - 27 percent of Michigan residents have arthritis, 30.5% of whom experience severe joint pain because of it. H.R. 3 can lower their total costs on most arthritis drugs from about $40,000 to $10,000 per year.

Asthma About 10.8 percent or 310,955 Michigan residents live with asthma. H.R. 3 can lower their total costs on most asthma drugs from about $1,400 to $270 per year.

HIV/AIDS In 2015, 777 Michigan residents were diagnosed with HIV. H.R. 3 can lower their total costs on most HIV drugs from about $15,000 to $6,000 per year.

Give Medicare the power to negotiate directly with the drug companies to bring down prices and create powerful new tools to force drug companies to the table to agree to real price reductions.

Make the lower drug prices negotiated by Medicare available to Americans with private insurance too, not just those on Medicare.

Stop drug companies ripping off Americans while charging other countries less for the same drugs by limiting the maximum price for any negotiated drug.

Create a new $2,000 out-of-pocket limit on prescription drug costs for people on Medicare.

Save taxpayers approximately $500 billion over the next ten years and reinvest that savings

Save American households $120 billion.

Save private businesses more than $40 billion.

Save taxpayers approximately $500 billion and reinvests that savings to expand benefits.

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Dingell votes in favor of legislation to drastically lower the cost of prescription drugs - Dearborn Press and Guide

Lifestyle Desk, , Updated Mon, 30 Dec 2019 09:27 AM IST

Uric acid is an rising drawback over time. Due to extend of this acid within the physique, an individual will get arthritis drawback. Arthritis causes swelling within the joints, inflicting insufferable ache. The impact of this ache begins displaying slowly on well being as nicely. Explain that the formation of uric acid within the physique is because of weak metabolism. Uric acid works by damaging blood cells. But yoga is one means which may eliminate this drawback. Today were telling you Three such yogasanas with the assistance of which youll management uric acid.

Abigale is a Masters in Business Administration by education. After completing her post-graduation, Abigale jumped the journalism bandwagon as a freelance journalist. Soon after that she landed a job of reporter and has been climbing the news industry ladder ever since to reach the post of editor at Our Bitcoin News.

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High Uric Acid Causes Arthritis And Joint Pain Yoga For Control - By controlling uric acid, these 3 Yogasanas will relieve joint ache, common follow -...

Tripterygium wilfordii, popularly known as thunder god vine root is primarily used for the treatment of rheumatoid arthritis in traditional Chinese medicine. The side effects of Trpterygium wilfordi are relatively low and hence it makes an attractive option for arthritis patients to improve their quality of life. Apart from an herbal approach in arthritis the Tripterygium wilfordii root is claimed to have antifertility, antiviral, and antitumor activities although not enough clinical evidence is available to support the claims.

This root extract is gaining significant acceptance among the arthritis patients due to its herbal nature and increasing consumers trust on herbal medicines. The regulatory aspects of herbal medicines favor the growth of herbal products market in USA, India, China and many European countries. This is expected to fuel the market growth of herbal products including Tripterygium wilfordii in the forecast period.

Tripterygium wilfordii Extract MarketSegmentation

The Tripterygium wilfordii root extract is segmented on the basis of dosage form, distribution channel and region. Tripterygium wilfordii is segmented on the bases of dosage form as tablets, capsules and powder. Originally available in powder form only, the benefits of Tripterygium wilfordii has created a costumer side demand and hence formulations of different kind have been developed and the shift in consumer trust towards herbal medicines is expected to drive the Tripterygium wilfordii market during the forecast period.

On the basis of distribution channel the Tripterygium wilfordii root extract market is segmented as retail, online retail, herbal specialty store and supermarket. With the increasing internet penetration in developing countries, the online sales of herbal supplements has also gained momentum and is expected at grow at a significant rate.

On the basis of region the Tripterygium wilfordii extract can be segmented into the following key regions; Western Europe, North America, Asia Pacific, Middle East and Africa. The Western European region, with its high expenditure on herbal medicine research is expected to drive the Tripterygium wilfordii market. The North American region has registered an ever increasing demand and acceptance in herbal products which is expected to further grow, contributing to a major factor for growth in the region. The Asia pacific region being the origin in use of Tripterygium wilfordii is also expected to see a steady increase in the market growth due to the a large populations belief in traditional remedie

Tripterygium wilfordii Extract Global Market Trends and Market Drivers:

The trends in use of traditional or herbal medicines is different for different regions, for example manufacturers do not need to register their products with FDA in US or get an approval, these are sold as dietary supplements. For this reason a large number of herbal products are flooding the American market and gaining high acceptance among masses.

The increased focus in innovation in herbal products in Western Europe is generating supply side demand and countries like Germany and France are spending high amounts on research. This is expected to act as a driving tool for the growth of the herbal product market including Tripterygium wilfordii root extract.

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In Indian regulatory system the marketing and sales of herbal products are furthermore liberal, herbal products are established products being used from a long time hence there is no safety study required for established products. This is expected to catalyze the growth of Tripterygium wilfordii root extract market.

The Tripterygium wilfordii root market is of great potential due to the above limited regulations and the high amount of faith in people for the use of herbal products. The unavailability of herbal practitioners and high concentration of the practitioners in certain regions is expected to be a major restrain in Tripterygium wilfordii root market.

Tripterygium wilfordii Extract Market Key Players:

The Tripterygium wilfordii powder from Asia Pacific constitutes for a major market share and hence some of the key prayers are also concentrated in these areas. Some of the key global players include; Shaanxi Jintai Biological Engineering Co., Ltd., Xian Hao-Xuan Bio-Tech Co., Ltd., Hunan Jin Kang Biotechnology Co., Ltd., Stanford Chemicals Co. Organic Herb Inc. among others.

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Tripterygium wilfordii Extract Market : Macroeconomic Factors to Create Positive Impact on the Industry Growth and its Potential - Market Research...

OBJECTIVES:

We aimed to assess the safety and efficacy of tocilizumab as monotherapy or in combination with methotrexate in a routine clinical practice setting in Tunisian patients with RA who did not respond to conventional treatment with disease-modifying anti-rheumatic drugs (DMARDs-IR).

A total of 51 DMARDs-IR adult patients with moderate to severe RA participated in a phase IIIb, open-label clinical trial. Patients received 8 mg/kg of tocilizumab every 4 weeks in combination with a DMARD or as monotherapy during 24 weeks. The study was extended to 24 other weeks for those who had at least a moderate response at the end of the initial phase. Safety and efficacy of tocilizumab were analysed.

Four patients discontinued treatment prematurely due to an adverse event. The most common AEs were hypercholesterolemia (18 cases), increased triglycerides (17 cases), increased transaminases (15 cases), rash (14 cases), neutropenia (7 cases), digestive disorders (3 cases) and respiratory disorders (3 cases). After 52 weeks, 90.5% of patients responded to treatment. At the end of the study, 61.9% of the patients had a mild RA and almost 50% of patients were in remission. Overall, 29.2, 6.3 and 4.3% of patients achieved ACR20, ACR50 and ACR70 responses, respectively. Additionally, the study showed a significant improvement in all individual parameters of ACR core data.

Treatment with tocilizumab was well tolerated and showed a fast and sustained efficacy in Tunisian patients with moderate to severe active RA who had an inadequate response to DMARDs.Key Points Up to 40% of RA patients remain inadequate responders to a prior csDMARD or a tumour necrosis factor inhibitor (TNFi) biological agent. A non-TNF biological agent like tocilizumab with or without methotrexate is recommended in those patients. In this study, tocilizumab treatment improved the number of responders, the number of patients in remission, and the evolution of disease activity. The meaningful clinical improvement seen denotes a rapid and sustained response to treatment. Tocilizumab presented a favourable safety profile with few withdrawals due to AEs, consistently with what was observed in other trials. This study provides new information about the safety and efficacy of tocilizumab in a patient population resembling that expected in clinical practice among the Tunisian population.

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Safety and Efficacy of Tocilizumab as Monotherapy or in Combination with Methotrexate in Tunisian Patients with Active Rheumatoid Arthritis and...

Paddy McGuinness, 46, revealed in an Instagram post last year that at the age of 44 hed been diagnosed with arthritis. Arthritis is a common condition that causes pain and inflammation in a joint.

Arthritis charity Arthritis Research UK said at the time: Were grateful to Paddy McGuinness for speaking out and showing other young people with arthritis that they are not alone.

People often think of arthritis as an older person's disease.

But Paddy is actually one of 11.8 million people under the age of 65 living with a musculoskeletal condition, including 2.7 million under 35 years old."

The two most common types of arthritis are osteoarthritis and rheumatoid arthritis.

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The main symptoms of osteoarthritis are pain and stiffness in your joints, according to the NHS, which can make it difficult to move the affected joints and do certain activities.

It adds: The symptoms may come and go in episodes, which can be related to your activity levels and even the weather. In more severe cases, the symptoms can be continuous.

You should see your GP if you have persistent symptoms of osteoarthritis so they can confirm the diagnosis and prescribe any necessary treatment.

Other symptoms you or your doctor may notice include:

Osteoarthritis can affect any joint in the body, but the most commonly affected areas are the knees, hips and small joints in the hands.

In osteoarthritis, the protective cartilage on the end of bones breaks down.

The main symptoms of rheumatoid arthritis are joint pain, swelling and stiffness.

The NHS advises: It may also cause more general symptoms, and inflammation in other parts of the body.

The symptoms of rheumatoid arthritis often develop gradually over several weeks, but some cases can progress quickly over a number of days.

The symptoms vary from person to person. They may come and go, or change over time.

You may experience flares when your condition deteriorates and your symptoms become worse.

Rheumatoid arthritis is an autoimmune disease, which means the immune system attacks the cells that line joints by mistake.

If you think you have the symptoms of osteoarthritis or rheumatoid arthritis, see your GP.

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Paddy McGuinness health: Star diagnosed with debilitating condition - the symptoms - Express

According to a new market study, the Rheumatoid Arthritis Treatment Market is projected to reach a value of ~US$XX in 2019 and grow at a CAGR of ~XX% over the forecast period 2017-2027. The presented study ponders over the micro and macro-economic factors that are likely to influence the growth prospects of the Rheumatoid Arthritis Treatment Marketover the assessment period.

The market report throws light on the current trends, market drivers, growth opportunities, and restraints that are likely to influence the dynamics of the Rheumatoid Arthritis Treatment Market on a global scale. The Five Force and SWOT analysis included in the report provides a fair idea of how the different players in the Rheumatoid Arthritis Treatment Market are adapting to the evolving market landscape.

ThisPress Release will help you to understand the Volume, growth with Impacting Trends. Click HERE To get SAMPLE PDF (Including Full TOC, Table & Figures) at https://www.futuremarketinsights.co/reports/sample/REP-GB-3119

Analytical insights enclosed in the report:

The report splits the Rheumatoid Arthritis Treatment Marketinto different market segments including, region, end-use, and application.

The report provides an in-depth analysis of the current trends that are expected to impact the business strategies of key market players operating in the market. Further, the report offers valuable insights related to the promotional, marketing, pricing, and sales strategies of the established companies in the Rheumatoid Arthritis Treatment Market. The market share, growth prospects, and product portfolio of each market player are evaluated in the report along with relevant tables and figures.

The study aims to address the following doubts related to the Rheumatoid Arthritis Treatment Market:

Get Access To TOC Covering 200+ Topics athttps://www.futuremarketinsights.co/toc/REP-GB-3119

key players and products offered

Potential and niche segments, geographical regions exhibiting promising growth

A neutral perspective on market performance

Must-have information for market players to sustain and enhance their market footprint

NOTE All statements of fact, opinion, or analysis expressed in reports are those of the respective analysts. They do not necessarily reflect formal positions or views of Future Market Insights.

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Rheumatoid Arthritis Treatment Market To Witness A Considerable CAGR Growth Through The Forecast Period 2017-2027 - Info Street Wire

Systemic Idiopathic Juvenile Arthritis Treatment Market (2018) Report Provides an in-depth summary of Systemic Idiopathic Juvenile Arthritis Treatment Market Status as well as Product Specification, Technology Development, and Key Manufacturers. The Report Gives Detail Analysis on Market concern Like Systemic Idiopathic Juvenile Arthritis Treatment Market share, CAGR Status, Market demand and up to date Market Trends with key Market segments.

The latest report about the Systemic Idiopathic Juvenile Arthritis Treatment market provides a detailed evaluation of the business vertical in question, alongside a brief overview of the industry segments. An exceptionally workable estimation of the present industry scenario has been delivered in the study, and the Systemic Idiopathic Juvenile Arthritis Treatment market size with regards to the revenue and volume have also been mentioned. In general, the research report is a compilation of key data with regards to the competitive landscape of this vertical and the multiple regions where the business has successfully established its position.

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Leading manufacturers of Systemic Idiopathic Juvenile Arthritis Treatment Market:

Alteogen Inc.Bristol-Myers Squibb CompanyEpirus Biopharmaceuticals, Inc.Johnson & JohnsonMomenta Pharmaceuticals, Inc.Mycenax Biotech Inc.Novartis AGOncobiologics, Inc.

Segment by RegionsNorth AmericaEuropeChinaJapanSoutheast AsiaIndia

Segment by TypeAdalimumab BiosimilarCanakinumabGolimumabTocilizumab BiosimilarOthers

Segment by ApplicationClinicHospitalOthers

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Scope of The Systemic Idiopathic Juvenile Arthritis Treatment Market Report:

This research report for Systemic Idiopathic Juvenile Arthritis Treatment Market explores different topics such as product scope, product market by end users or application, product market by region, the market size for the specific product Type, sales and revenue by region forecast the Market size for various segments. The Report provides detailed information regarding the Major factors (drivers, restraints, opportunities, and challenges) influencing the growth of the Systemic Idiopathic Juvenile Arthritis Treatment market. The Systemic Idiopathic Juvenile Arthritis Treatment Market Report analyzes opportunities in the overall Systemic Idiopathic Juvenile Arthritis Treatment market for stakeholders by identifying the high-growth segments.

A detailed overview of the geographical and competitive sphere of the Systemic Idiopathic Juvenile Arthritis Treatment market:

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Table of Content of The Report

Chapter 1- Systemic Idiopathic Juvenile Arthritis Treatment Industry Overview:

1.1 Definition of Systemic Idiopathic Juvenile Arthritis Treatment

1.2 Brief Introduction of Major Classifications

1.3 Brief Introduction of Major Applications

1.4 Brief Introduction of Major Regions

Chapter 2- Production Market Analysis:

2.1 Global Production Market Analysis

2.1.1 Global Capacity, Production, Capacity Utilization Rate, Ex-Factory Price, Revenue, Cost, Gross and Gross Margin Analysis

2.1.2 Major Manufacturers Performance and Market Share

2.2 Regional Production Market Analysis

Chapter 3- Sales Market Analysis:

3.1 Global Sales Market Analysis

3.2 Regional Sales Market Analysis

Chapter 4- Consumption Market Analysis:

4.1 Global Consumption Market Analysis

4.2 Regional Consumption Market Analysis

Chapter 5- Production, Sales and Consumption Market Comparison Analysis

Chapter 6- Major Manufacturers Production and Sales Market Comparison Analysis

Chapter 7- Major Classification Analysis

Chapter 8- Major Application Analysis

Chapter 9- Industry Chain Analysis:

9.1 Up Stream Industries Analysis

9.2 Manufacturing Analysis

Continued here:
Systemic Idiopathic Juvenile Arthritis Treatment Market By Production, Manufacturer, Revenue Analysis And Forecast To 2029 - Bulletin Line

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My grand daughter is 6 years old and my goal is to be physically and mentally fit to enjoy her. Well after five years it was not going so well. I had a very serious sit down conversation with self last year around this time. No more minute resolutions. No more unmet goals. No more start and stop diets. I need help; this has been a 65 + year journey and things were not going as well as I had hoped. I downloaded a habit tracker and put short doable daily and weekly goals. For movement, I have the following daily goals:

I also have a weekly hot yoga class at 7 AM on Sunday mornings that I look forward to. The class is 90 minutes of stretching and meditating in the heat which is awesome for arthritis which is in various places in my body.

Over the year, I lost weight, my flexibility increased and my diet shifted as I no longer craved foods that were not good for me. Honestly, I did other things such as increase my prayers, meditation, breathing and affirmation practices. But the key was the physical movement it always accelerated all the other practices. While I did not always do every practice every day, the habit tracker helped me stay on target by starting my count over when I missed a practice.

This year both my mind and body are in a better place than last year. The goal for 2020 is to add real cardio and reap more relief for sleep and stress. I joined my local gym last month; my plan is to enroll in a few classes and add it to my habit tracker. Slow progress is still progress.

Weekly Prompt

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This time last year I laughed and cried with my body - Thrive Global

Helen Aristar-Dry likes to garden, but she doesnt want the aches and pains that could follow an enjoyable time spent out at her 1-acre property in Dripping Springs.

Ive always been interested in easier ways to garden, said Aristar-Dry, 73, who has had rheumatoid arthritis for about 50 years. For someone like herself, she said, Youre always looking for ways to lessen the strain on your joints.

Rheumatoid arthritis is an autoimmune and inflammatory disease that often affects hands, wrists, knees and ankles. Symptoms can include swelling, pain and stiffness in more than one joint, as well as fatigue and weakness.

Over the years having had several surgeries and used a wheelchair at times she has learned tactics to help her out. Sitting alongside her raised bed gardens used for growing Swiss chard and kale, along with other things she is glad she can still relish working with flowers, vegetables and dirt.

Its just really a good pastime, she said.

Aristar-Dry has a doctorate in linguistics, and after she retired in 2013, she had more time for a favorite hobby. She became a Hays County master gardener in 2015, and she has researched a variety of ways to make it easier for her in the garden.

Evaluating her resources and careful planning have helped, Aristar-Dry said. In addition to finding assistance for heavy jobs, she divides up large tasks into shorter chunks.

I rarely work more than 30 minutes at a time, she said. By then my hands will be hurting, so its time to quit.

If I overdo it, Im going to feel bad, she said. She also keeps a to-do list, so I can see whats a good job that fits the time I have. I dont do big projects.

In addition, she opts to use equipment that isnt weighty. I use a childrens rake with a long handle, because its much lighter, she said. Its less stress on the joints if you dont have to carry heavy stuff around. She uses a cart, rather than a wheelbarrow, to move large items such as bags of dirt.

She needs to be more vigilant about keeping her tools sharpened so they dont require as much strength to use, she said. Thats one I need to work on, but it makes a big difference.

Effective use of logistics has also aided her, and that can be as simple as storing her tools near the garden. Shes a big advocate of raised beds of all kinds where she can even sit down to work.

Theyre less demanding physically, she said. As well, she wishes she had more space between garden beds to allow more room for a bench or a cart to get through the path.

She carefully selects plants that are easier to care for, such as drought-tolerant natives, she said. As well, she likes to use plants that have been designated as Texas Superstars, which perform well under Texas tough growing conditions, according to texassuperstar.com.

Aristar-Dry prefers to use perennial plants rather than annuals, because with perennials, you put them in once and they come back, she said. Perennials are just much easier.

She keeps in mind some ergonomic principles, such as using her joints in a neutral position, which she described as about midpoint of their range, and other basics. In addition, she helps limit discomfort through the selection of ergonomically designed gardening tools. These tools help the user reduce stress and injuries from overuse of the body.

She has some long-handled tools that can help let her back remain straight. Some tools such as a waist-high weeder have an O-shaped handle that offers more grip surface, and its easy to use two hands with, she said.

Along with other selection criteria, she picks various tools that can let her keep her wrist straight, she said. (Often, she said, many tools require users to bend their wrists.)

Other implements can also help; she uses a special faucet turner to make it easier to turn on and off the water outside so she doesnt have to use as much strength. She uses a garden kneeler that can serve as a seat, she said. When I sit down and keep my back straight, I can work a whole lot longer.

Putting together information on the tactics she uses, as well as including more details about ergonomics and such, she has given a presentation on called Ergonomic Gardening: Gardening to Avoid Aches and Pains about a half-dozen times at the Hays County Master Gardeners Associations In the Garden series. Emphasizing that she doesnt have any medical training but that she has found these methods useful to her.

The talk is popular, said Phyllis Janowski, past president of the Hays County Master Gardeners Association.

People found it helpful to learn about some measures they could take, even for those who dont usually get aches and pains from gardening, she said.

Now that Aristar-Dry has found workarounds to help her, she still gets to take joy in the garden, she said. I think its really just rewarding to be out there with growing things.

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Find the right tools to garden with arthritis - austin360

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Arthritis is caused by inflammation of the joints. There are many foods and ingredients that can ease inflammation and may help relieve some of the joint pain associated with arthritis. Adding these foods to a healthy diet can help alleviate our arthritis symptoms. Lets have a look on list of food and ingredients that we can try using at our homes in order to get some relief from the arthritis-related pain.

Grains

While considering our options in the bread, cereal, and pasta, we should avoid refined grains. Not only are they highly processed grains but limited in nutrition, can lead to inflammation throughout the body. For Example, switching from refined flour to whole-wheat flour in our recipes can increase the intake of nutrients and potentially lower inflammation. Likewise, barley is filled with 6 grams of fiber per cup, a perfect addition to soups, stews and risotto dishes.

Nut and seeds

Nuts and seeds are a useful component in our diet. Most importantly it offers a variety of health benefits to people with arthritis. With their high ALA content, nuts like walnuts are omega-3-containing and researchers studying their effects have found that they lower C-reactive protein (CRP), an inflammation marker linked to an increased risk of cardiovascular disease and arthritis. Likewise, chia seeds are also an excellent source of anti-inflammatory ALA, but their greatest benefit is likely their high fiber content.

Fruit and vegetables

Fruits are naturally sweet and have a substantial amount of antioxidants, protein, vitamins, minerals, and other nutrients, just like red raspberries, tart cherries and strawberries are filled with antioxidants that help to get rid of radicals that encourage inflammation whereas Vegetables are rich in antioxidants and other nutrients that protect against cell damage and lower inflammation throughout the body, including in the joints. For example, fresh, leafy vegetables such as broccoli, spinach, brussels sprouts, kale, swiss chard, and bok choy are loaded with antioxidants such as vitamins A, C, and K which protect cells from free radical harm.

Spices

According to traditional Eastern medicine, ginger and turmeric are two spices that have anti-inflammatory properties. Along with its anti-inflammatory properties, some studies have shown ginger can also reduce osteoarthritis symptoms, if not in food one can also opt-in the form of a herbal supplement -like IMOVE containing popular, active and trusted pain management ingredients such as ginger and turmeric. It also includes Glucosamine & Chondroitin for joint repair and lubrication, thereby offering full joint treatment.

Fish

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are called marine fatty acids as they are derived from fish, adding omega-3 sources to our diets inflammation could be reduced. Fatty fish such as salmon, tuna, sardines, and mackerel are the best sources of marine omega-3s. Anti-inflammatory effects of omega-3s are helpful not only for the relief of arthritis but also for the prevention of other inflammatory diseases, such as heart disease. It is usually suggested to eat 3 to 6ounce serving of these fish two to four times a week to reduce inflammation and protect the heart Omega-3-rich fishes are also high in mercury, which causes brain and nervous system can harm if consumed in large quantities. Its important to choose smaller fish that have less mercury.

(Disclaimer: Writer is Sargam Dhawan, Director, Planet Herbs Lifesciences Pvt Ltd. Views expressed are a personal opinion.)

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Food and ingredients to cure arthritis! - Elets

Study on the Rheumatoid Arthritis Treatment Market

The comprehensive report published by Future Market Insights (FMI) offers an in-depth intelligence related to the various factors that are likely to impact the demand, revenue generation, and sales of the Rheumatoid Arthritis Treatment Market. In addition, the report singles out the different parameters that are expected to influence the overall dynamics of the Rheumatoid Arthritis Treatment Market during the forecast period 2017-2027.

As per the findings of the presented study, the Rheumatoid Arthritis Treatment Market is poised to surpass the value of ~US$ XX by the end of 2029 growing at a CAGR of ~XX% over the assessment period 2017-2027. The report includes a thorough analysis of the upstream raw materials, supply-demand ratio of the Rheumatoid Arthritis Treatment in different regions, import-export trends and more to provide readers a fair understanding of the global market scenario.

ThisPress Release will help you to understand the Volume, growth with Impacting Trends. Click HERE To get SAMPLE PDF (Including Full TOC, Table & Figures) at https://www.futuremarketinsights.co/reports/sample/REP-GB-3119

The presented study addresses the following queries related to the Rheumatoid Arthritis Treatment Market:

The presented market report dives deep into understanding the business strategies adopted by leading market players in the global Rheumatoid Arthritis Treatment Market. Further, the SWOT analysis for leading market players is enclosed in the report along with the revenue share, pricing analysis, and product overview of each company.

The extensive study on the Rheumatoid Arthritis Treatment Market pinpoints the different factors that are likely to influence the prospects of the Rheumatoid Arthritis Treatment Market in each region.

Decisive Information Enclosed in the report:

Get Access To TOC Covering 200+ Topics athttps://www.futuremarketinsights.co/toc/REP-GB-3119

key players and products offered

Potential and niche segments, geographical regions exhibiting promising growth

A neutral perspective on market performance

Must-have information for market players to sustain and enhance their market footprint

NOTE All statements of fact, opinion, or analysis expressed in reports are those of the respective analysts. They do not necessarily reflect formal positions or views of Future Market Insights.

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Future Market Insights (FMI) is a leading market intelligence and consulting firm. We deliver syndicated research reports, custom research reports and consulting services which are personalized in nature. FMI delivers a complete packaged solution, which combines current market intelligence, statistical anecdotes, technology inputs, valuable growth insights and an aerial view of the competitive framework and future market trends.

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Rheumatoid Arthritis Treatment Market Industry Analysis, Trend and Growth, 2017-2027 - Info Street Wire