StemCell Therapy

How many times have we all grabbed a knife to open a pack of food, spilt it across the kitchen because the pack was too hard to open, been unable to read the text on the pack (even with glasses on) and then vowed to never buy that brand again? Now imagine if you were part of the ageing population, hospitalised, a consumer with a disability, an arthritis sufferer orachild.

All too often, accessible packaging is not considered when designing products, which in turn leads to unnecessary frustration when opening and closing packs, reading the ingredients and opening instructions on packaging. It is important that packaging technologists consider how their packaging design could affect someones ability to eat, drink and the flow on of wasting food.

Research from Arthritis Australia in 2018 shows that: All consumers struggle with packaging, but the growing ageing population, consumers with disabilities, arthritis sufferers and children are impacted the most. 44 per cent of consumers struggle with packaging every day. 92 per cent of consumers have spilt or damaged a product when trying to open the packaging. When consumers experience hard-to-open packaging:o 56 per cent look for the product but in a different typeof packaging.o 21 per cent look at buying a competitors product. 65 per cent of consumers have had to wait for someone to come and open packaging for them. 1-in-2 Australians have injured themselves opening packaging including deep cuts and chippedteeth. 89 per cent of consumers are currently feeling frustrated or furious with packaging. 67,000 people in the UK visited hospitals casualty departments every year due to an accident involving food and drinkpackaging.So, I ask you do you consider accessible design and ease of use critical design elements on your packaging? Are your packaging technologists using available resources and training to better understand the needs of this consumer market?

Step one: accessibility packaging design guidelinesIf you arent using the Accessibility Packaging Design Guidelines developed by Arthritis Australia, in conjunction with Brad Fain from Georgia Tech Research Institute, and available in New Zealand through a partnership with Arthritis New Zealand, then you could already be losing customers whose abilities are not being consideredand their needs are notbeing met.

Key guidelines include that packaging must be easy to open and use for those with limited functional abilities, packaging labelling must be highly legible, and packaging shall be fit-for-purpose and must be able to demonstrate accessibility.

Step two: accessible packaging design trainingThe Australian Institute of Packaging (AIP), in conjunction with Arthritis Australia and Georgia Tech Research Institute, have developed a one-day training course on accessible packaging design. The course allows attendees to become aware of the required design requirements and understanding the ease-of-use packaging design tools, which include examples from around the world. It also providesinformation on changinghousehold demographics, meal preparationrequirements and case studies from users.

Attendees will learn measuring techniques, injuries caused by packaging and current consumer satisfaction levels with packaging accessibility. The course offers an activities-based approach, hands-on team exercises letting participants understand the constraints on current packaging designs for people with disabilities, arthritis sufferers, children and the ageing population. This includes the testing with simulation gloves that have been developed by Georgia Tech Research Institute in the US and reading glasses from a UK researcher. Attendees will leave the course with a differentapproach to packagingdesign; an approach that includes all sectorsofourcommunity.

Step three: recognition of innovative accessible packaging designThe AIP, in conjunction with Arthritis Australia and New Zealand, has developed a new Accessible Packaging Design Award that is designed to recognise packaging that is accessible, intuitive, easy-to-open and innovative. The judges are looking for accessible packaging design, which includes measuring techniques, understanding injuries caused by packaging and consumer satisfaction levels with packaging accessibility. The inaugural award winners were announced as a part of the Australasian Packaging Innovation & Design Awards (PIDA), which are run by the AIP and are designed for Australia and New Zealand.

Finalists for 2019 were SPC Ardmona, Flavour Creations, Moana New Zealand & Sealed Air for Cryovac Grip and Tear and Campbell Arnotts. All four finalists deserve to be recognised for incorporating accessible packaging design into their ranges and it is inspiring to see some of the innovations that they have beenworking on.

The 2019 Gold Award went to SPC Ardmona. They developed their SPC ProVital Easy-Open Diced Fruit in Jelly range that is designed for all consumers to open, including those with reduced fine motor skills. It has dexterity and strength, and on-pack communication is clear, crisp and legible for all. This design achieved easy-to-open certification as well as an ISR +8 Accessibility Rating (i.e. the product is universally easy to open, with 95 per cent of the population able to open the pack without tools).

The 2019 Silver Award went to Flavour Creations who developed its pre-thickened Ready-to-drink (RTD) packaged in the new dysphagia Cup and Cup Holder that were designed to specifically increase rates of hydration and decrease rates of malnutrition for residents/patients with dysphagia. Along with the reusable holder and plastic over seal, the snap fitting portion control cup has a large overhanging tab that is textured and clear peel back wording to make it obvious to the consumer how toopen the product.

A Special Commendation went to Moana New Zealand & Sealed Air for Cryovac Grip and Tear (including small tab), which was designed to foster ease of use to packaged meat, poultry, and seafood products for processing,food service and retail markets. This accessible packaging design enables convenient product access using a packaging design that is simple and intuitive for consumers to use (irrespective of their age or functional abilities). Previously, these difficult to open items required opening tools, which could easily cause injuries. The grip-and-tear feature means the packs can now be opened by a simple hand action.

Sealed Air have undertaken design innovation in the development of the grip-and-tear feature to meet both the food handling and food protection requirements for the range of products proposed for thepackaging format.

Accessible packaging design that is intuitive, easy-to-open and innovative should be an integralpart of your packaging and we encourage you to integrate this critical element into your future NPD processes. Imaginethedifference you couldmake.

The rest is here:
Accessible packaging design is the key to helping consumers | Food & Beverage - FOOD Magazine - Australia

Whole-body cryotherapy or the practice of submerging yourself into a deep-freezing tank has exploded in popularity over the past few years, especially among pro athletes and celebrities. Tons of gyms, spas and wellness centers now offer the treatment, claiming it can boost metabolism and ease symptoms of inflammation and pain for a long list of health conditions (like arthritis, fibromyalgia and migraines).

But not everyone is so sure about the practice. Some people believe its a potentially dangerous hoax, and others like former Pittsburgh Steelers wide receiver Antonio Brown have sustained frostbite injuries from the cold tanks. One woman was even found dead in a cryotherapy tank in Nevada a few years ago.

Given the major lack of evidence we currently have on whole-body cryotherapy, many experts are skeptical about its ability to heal and detox the body and warn people to think twice before walking into a tank.

What goes on in cryotherapy?

Whole-body cryotherapy, also sometimes called WBC or super-cooling, involves stripping down to socks and gloves and stepping into a human-sized chamber thats set to about -200 degrees Fahrenheit or colder for two to four minutes. The skin temperature then drops, as does overall body temperature, both of which are largely dependent on the persons gender, weight and fitness level.

Those who are pro-WBC claim the frigid temps constrict and then widen the blood vessels, which causes the body to release toxins and endorphins. This play on blood flow is thought to alleviate pain, boost metabolism, slow the aging process and have all sorts of healing abilities.

Most single sessions will cost you upward of $80, with a monthly membership being even more.

We dont have too much research on cryotherapy.

Think of a time you got injured. You likely used a cold pack to numb the wound and ease the pain. Localized cooling treatments like that are known to reduce blood flow and lower pain levels, inflammation and swelling.

Whole-body cryotherapy is based on this same idea of utilizing cold as a therapeutic agent but the evidence just isnt there to back it up. And because WBC is not regulated by the Food and Drug Administration, the research we do have has mostly been conducted by private cryotherapy studios or practitioners who have a financial tie to it, according to Dr. Robert Shmerling, a rheumatologist and associate professor of medicine at Beth Israel Deaconess Medical Center.

In fact, the FDA states that despite claims by many spas and wellness centers to the contrary, the U.S. Food and Drug Administration (FDA) does not have evidence that WBC effectively treats diseases or conditions like Alzheimers, fibromyalgia, migraines, rheumatoid arthritis, multiple sclerosis, stress, anxiety or chronic pain.

The lack of regulation by the FDA also means that theres no golden rule regarding the temperature and duration of cryotherapy. As a result, different wellness centers use different cooling technologies. This has made it particularly difficult to reliably study the effects of WBC, according to Erich Hohenauer, a senior researcher at the University of Applied Sciences and Arts of Southern Switzerland who has conducted research on cryotherapy.

Furthermore, the studies out there have predominantly looked at the effects in men, so its even more unclear how the treatment affects women, Hohenauer noted.

jacoblund via Getty Images

Heres what the science does say.

Two of the biggest studies a report from 2014 and another from 2015 looked at a total of 14 previous studies and concluded that theres not enough evidence to say whether or not the cooling treatment has any significant impact on pain or muscle soreness. And though WBC may improve some peoples perception of recovery, the researchers determined its probably best to just use a local ice pack on any pain or soreness we know thats effective (and affordable), they said.

More recent research from 2017 evaluated 10 previous WBC articles and determined that patients often note improvements in pain, soreness, stress and post-exercise recovery. In some cases, WBC does seem to have anti-inflammatory effects and the more often its done, the greater the effects. But, overall, the data is mixed: Many patients reported no improvements.

Some health experts suspect there may be a powerful placebo effect at play.

For something subjective, such as pain rather than something objective, like the size of a tumor you can demonstrate that the expectation of benefit leads to benefit, Shmerling said.

Shmerling said it may be similar to the phenomenon that happens with a sugar pill: In a study, if you tell some participants with pain theyre getting a powerful pain reliever and others theyre getting a sugar pill, more people in the first group will report pain relief.

The same could be true for WBC: You tell people with migraines that it works great for headaches; they get in this horribly cold container for two minutes and some percentage of people will say they feel better, Shmerling said.

Cryotherapy isnt risk-free.

There are also some potential risks to be aware of with WBC. According to Hohenauer, the extremely low temperatures can cause skin burns and inhaling cryocabins the vaporized liquid nitrogen in the tanks can be life threatening in some cases.

There are also a lot of contraindications for whole and partial body cryotherapy which should be taken into account, Hohenauer added. For example, those with heart disease, respiratory issues or hypothyroidism should definitely avoid WBC.

For now, most health care providers are holding off on recommending WBC to patients until the science catches up. The body of literature on WBC is growing, and we may eventually find out cryotherapy is indeed an effective treatment for pain and soreness. Until we have more proof, though, its best to talk to your doctor and proceed with caution.

Given the lack of evidence, expense and at least some risk of harm, I would not recommend it, Shmerling said, adding, Then again, if someone feels better doing it and has had no side effects, I would not discourage it.

The rest is here:
This Is Your Body On Cryotherapy - HuffPost

BACKGROUND:

Single photon emission computed tomography combined with computed tomography (SPECT/CT) could potentially aid in diagnosing periarticular arthritis/activity and progression, facilitate effective treatment options, and evaluate the effect surgery has on the clinical outcome of patients with ankle arthritis. The goal of our study was to assess SPECT/CT activity in the ankle and periarticular joints before and after ankle fusion surgery and determine whether it was associated with clinical pain and function scores.

Thirty-four patients recruited into this study underwent either arthroscopic or open ankle fusion. X-ray (XR) and SPECT/CT imaging was obtained as well as completion of patient Ankle Osteoarthritis Scale (AOS) and 36-item Short Form Survey (SF-36) questionnaires preoperatively and at 6 months postoperatively. Ankle, subtalar, and talonavicular joint arthritis grading on XR and CT, along with SPECT/CT activity, was evaluated by 2 nuclear medicine radiologists. Data were assessed for normality and analyzed with the appropriate comparative test.Pvalue was set at <.05. Thirty patients (31 ankles) completed follow-up and were analyzed.

SPECT/CT activity showed no significant difference in the ankle joint at 6 months postoperatively while periarticular joint activity significantly increased (P< .05). Six months postoperatively, patients had significant improvements in their AOS and SF-36 scores (P< .05). SPECT/CT grading of all joints analyzed, however, was not associated with AOS or SF-36 scores preoperatively or at 6 months postoperatively.

In this study, intensity of activity as evaluated by SPECT/CT in periarticular hindfoot joints in patients who had ankle arthrodesis was not associated with clinical/functional scores at 6 months postoperatively.

Level IV, diagnostic study.

Original post:
Preliminary Experience With SPECT/CT to Evaluate Periarticular Arthritis Progression and the Relationship With Clinical Outcome Following Ankle...

An arthritis diagnosis is a life-changing experience. You suddenly have to think about treatment options, assess whether you want to take any medications, and come to terms with the fact that theres no cure for your pain. Whats more, you have a million questions and with so much conflicting information online, its hard to find the right answers. Trying to manage all of this alone is impossible you need to surround yourself with people who can give you the support you need, and help to find the right arthritis pain relief options for you. So, who should you include in your support network? While it differs from person to person, heres an example of where you may want to start:

Friends and Family

Your friends and family are an essential component of your support team. No doubt theyve been with you through the good and the bad for your whole life and this is no different! You can decide how involved you want your loved ones to be on your arthritis journey. Perhaps you just want to be able to talk to them when things get overwhelming, or maybe you want them to play a more hands-on role and accompany you during your visits to the doctor it can certainly help to have someone taking notes and helping you to remember all the new information youre receiving.

Primary Care Physician

Following your arthritis diagnosis, youre probably going to be seeing a lot more of your Primary Care Physician. Make sure they are someone you feel comfortable talking to, and someone who takes the time to address your concerns and questions. Its important that you are as open and honest with them as possible make sure they know about your lifestyle habits and any medications you are currently taking. With this information, they will be able to create a treatment plan that is specifically tailored to your needs and gives you the best chance of waving goodbye to your arthritis pain.

Specialist (if necessary)

Different types of arthritis require different levels of medical intervention, and depending on your specific needs you may or may not need to visit a specialist. If you have rheumatoid arthritis you should definitely see a rheumatologist, as this is a specialized condition resulting from immune system dysfunction. A rheumatologist will assess the severity of your arthritis and devise a treatment plan based on this. Over time, theyll be able to monitor how the disease progresses and adjust your treatment as necessary.

Psychologist/Mental Health Care Specialist

Seeing a psychologist might seem like a big deal, and its certainly not necessary for everyone. However, depression and anxiety are extremely normal and common among arthritis patients chronic pain affects mood, and its hard to maintain a positive outlook when youre in constant discomfort. A newly diagnosed arthritis patient experiences many different emotions and changes to their life, and it can be helpful to have someone to talk the whole thing over with. Of course, your friends and family can provide emotional support, but sometimes its nice to have a professional (and a stranger) on board as well. They can help you to develop coping mechanisms and different methods for managing the diverse set of emotions that come with arthritis.

Physical Therapist

Exercise is a very important aspect of your arthritis treatment plan. Staying as active and mobile as possible is crucial when it comes to reducing your pain and improving mobility. However, many exercises are not suitable for arthritis sufferers, and it can be difficult to know which types of exercise will benefit you the most. This is where a physical therapist can help they will be able to provide you with exercises to maintain your range of motion, improve your mobility and reduce your arthritis pain.

Dietician

Many people find that making modifications to their diet can improve their arthritis symptoms. By avoiding inflammatory foods and eating a healthy, balanced diet, you may see a welcome reduction in your arthritis pain. A dietician can show you which foods to avoid and which foods to eat more of. If youre looking to lose weight, they can help you there too carrying extra weight puts more stress on your joints and worsens the pain associated with arthritis.

Dealing with an arthritis diagnosis is no easy task, but there is a whole group of wonderful, caring people out there just waiting to help you out. Make sure youre never afraid to ask questions or seek help when you need it thats exactly what your arthritis support network is there for.

More here:
Coping with Arthritis: Who Should be in Your Support Group? - Lifesly.com

As a 60-year-old senior who has used cannabis for 44 years, Karen Watts Nauman of Comfortably Numb CBD has always believed in the medicinal healing of this plant medicine. However, she admits her fellow senior consumers lack an understanding of the full medicinal benefits of cannabis and hemp.

My generation just got whatever weed we could get and didnt know anything about the science.

After she tried CBD with her husband and they were impressed by how their health improved significantly , they thought, Our peers need to know about CBD! Thats when they started Comfortably Numb to educate older adults about how CBD can be an alternative to Big Pharma in treating ailments that impact seniors, such as pain and inflammation, sleep disorders, bone health, and lack of appetite.

In their work, they explain the importance of healing the bodys endocannabinoid system, explaining that there are few ways to better support this system than with CBD. High on effectiveness and low on side-effects, CBD is a near perfect method of managing symptoms.

RELATED: Marijuana Use Among Seniors Is Growing Fast

For those looking to introduce their senior family members to CBD, Watts Nauman notes education is key. Our generation likes studies backed by science. She suggests focusing on the seniors specific problems and how CBD can address these concerns. CBD needs to be looked at like a vitamin that should be taken every day for maximum benefit. Also, seniors should discuss their CBD use with their doctor to avoid any complications due to other medications they are taking. According to Watts Nauman, the website Project CBDis an excellent resource that resonates well with seniors.

Photo by Caiaimage/Trevor Adeline/Getty Images

Watts Nauman advises starting seniors with a topical hat contains at least 125mg CBD per ounce of lotion/salve/oil but would then go higher to 250mg CBD per ounce. If they have arthritis, or are using it for pain, maybe look for products that contain other carrier oils that work well with this particular issue. She adds that they need to apply it three to four times per day, especially in the beginning.

RELATED: How CBD Helps Seniors Exercise

Also, Watts Nauman suggests this population avoids sweet edibles, like CBD chocolate. Seniors like sweets and will want to go this method and it is cheaper to try. But as many edibles use isolate, more than likely, they wont feel anything immediately. Then they will be angry at the money they spent and tell others it doesnt work. Soft-gels and CBD teas can be good alternatives, but only if they have a high milligram count and are made using full spectrum CBD.

After seniors experiment with topicals, Watts Nauman recommends an oil tincture or a nasal inhaled delivery system. These delivery methods are better for bioavailability and feeling the effects faster. She offers these recommendations for dosing. Start them with a minimum of 8-12mgs full spectrum or 20-30mg isolate taken in the early evening after a meal. Then stay on this dosage for about three days to determine how it works with their needs. Once they get a feel for their best dosage, then they can go into micro-dosing and using other delivery methods.

Here is the original post:
Educating Older Adults About CBD What You Need To Know - The Fresh Toast

Galleries and exhibitions

The Kirkland Library, 17100 Hymus Blvd. in Kirkland, presents an exhibit of paintings by Karel de Zeeuw starting Saturday and continuing to March 29. Vernissage on Sunday from 2 to 4 p.m. Call 514-630-2726, local 3216.

The Dorval Museum of Local History and Heritage, 1850 Lakeshore Dr. in Dorval, presents the exhibition Headlines, which explores the history of womens issues in Canada through an innovative lens, with a collection of more than 60 hats from different eras. Continues until May 10. Call 514-633-4175.

The Stewart Hall Art Gallery, 176 Lakeshore Rd. in Pointe-Claire, presents the exhibition Material, Mass and Dust, starting Saturday and continuing to April 19. Vernissage on Sunday from 2 to 4:30 p.m. Call 514-630-1254.

Montreal Aviation Museumon McGill Universitys MacDonald campus, 21111 Lakeshore Rd. in Ste-Anne-de-Bellevue, is open to the public Saturday-Tuesday from 10 a.m. to 3 p.m. Call 514-398-7948 or visitcahc-ccpa.com.

Lakeshore Light Opera presents Iolanthe by Gilbert & Sullivan until March 14 at Lakeside Academy, 5050 Sherbrooke St. in Lachine. For tickets ($15 to $30) visit llo.org or call 514-804-4900.

Demystifying Art: David Armstrong Six. Lecture with the artists on March 18 from 10 to 11 a.m. at the Stewart Hall Art Gallery, 176 Lakeshore Rd. in Pointe-Claire. Free. Call 514-630-1254.

Murder Mystery Dinner Theatre A Grand Murder written and directed by Steve Gillam on March 28, April 4, 18, 25 and May 2 at 6 p.m. at Dorval-Strathmore United Church, 310 Brookhaven Ave. in Dorval. Tickets: $40, $35 for seniors/students. Call 514-793-9879 or email dsuc13churchevents@gmail.com.

St-Eugene: Suburb Lights (Cabaret Nights). Indie-folk band from Montreal on Friday at 8 p.m. at the Peter B. Yeomans Cultural Centre, 1401 Lakeshore Dr. in Dorval. Tickets: $20. Visit ville.dorval.qc.ca.

Solstice. World music with Montreal-based Celtic folk band Solstice on March 15 at 3 p.m. at the Pointe-Claire Cultural Centre, 176 Lakeshore Rd. in Pointe-Claire. Free, but passes required. Call 514-630-1220, local 1774.

Ensemble stn: In the Shadow of Mount Damavand (Divertissimo Series) on Sunday at 11 a.m. at the Peter B. Yeomans Cultural Centre, 1401 Lakeshore Dr. in Dorval. Tickets: $10, $5 for children aged 6-12, free for children five and under. Call 514-633-4175.

Orchestre Mtropolitain: A Tale of Two Cities. Classical grand concert on March 20 at 8 p.m. at Saint-Joachim Church, 2 Ste-Anne Ave. in Pointe-Claire. Tickets: $22, $16 for students/seniors. Call 514-630-1220, local 0.

Lakeshore Chamber Music Society presents Beethoven 250 with Elizabeth Dolin (cello) and Wei-Tang Huang (piano) on March 20 at 7:30 p.m. at Union Church, 24 Maple Ave. in Ste-Anne-de-Bellevue. Admission: $20, $15 for seniors (60+) and students, 16 and under admitted for free. Visit lakeshorechambermusic.org.

Lakeshore Chamber Orchestra spring concert on March 21 at 7:30 p.m. at Valois United Church, 70 Belmont Ave. in Pointe-Claire. Donation: $10, 18 and under admitted for free. Visit lakeshorechamberorchestra.ca.

St. Columba concerts presents a piano concert featuring Olivia Musat on March 28 at 7:30 p.m. at the Church of St. Columba by-the-Lake, 11 Rodney Ave. in Pointe-Claire. Donation: $15 (free for children). Call 514-364-3027.

Kirkland Concert Band, a community wind ensemble band, rehearse every Wednesday from 7 to 10 p.m. at the Kirkland Chalet, 81 Park Ridge Rd. in Kirkland. They are a group of amateur, volunteer musicians who play concerts in parks, senior residences and other locations with the goal of bringing music into the community. Visit kirklandconcertband.org.

Briarwood Presbyterian Church Choir is looking for singers to join their choir. The service is from 10 to 11 a.m. every Sunday at 70 Beaconsfield Blvd. Call 514-695-1879.

The Low Vision Self-Help Association meets on Wednesday from 1 to 3:30 p.m. at Briarwood Presbyterian Church, 70 Beaconsfield Blvd. in Beaconsfield. Topic: Adapting Our Home for Low Vision. All welcome. Call 514-694-2965.

Living with Arthritis. AWISH offers a series of 5-sessions with coping tips, nutrition, exercise, alternative therapies, etc. starting April 6 from 6:30 to 8:30 p.m. at Chalet Holleufeur in Kirkland. To register, call 514-631-3288 or arthritis@awishmontreal.org.

Lou Gehrigs Disease SLA/ALS Family Caregiver support group, offered by NOVA West Island, meets the first Monday of every month from 6 to 8 p.m. in Beaconsfield. Call 514-695-8335, local 205.

AWISH Montreal offers exercise for arthritis with a movement professional on Monday evenings from 6 to 7:30 p.m. at the Sarto Desnoyers Community Centre in Dorval. Classes ongoing. Free trial for first timers. To register, call 514-631-3288 or email arthritis@awishmontreal.org.

Compassionate Friends, an international self-help support group for bereaved parents, meets on the first Tuesday of each month. For information and support, call 438-257-0881.

Overeaters Anonymous, a 12-step recovery group for compulsive overeaters, anorexics and bulimics. No weigh-ins, dues or fees. Weekly meetings at various locations. Call 514-488-1812.

ANEB open support group for people (aged 17+) suffering from an eating disorder and their loved ones. Open to those suffering or living with an obsession of their body image, as well as support groups for their loved ones. The groups are confidential, free of charge and require no registration or long-term commitment. They are offered in English, on the West Island. Visit anebquebec.com/en/services/groupe-de-soutien-ouverts.

GRASP Grief Recovery After a Substance Passing. A free peer support group for people grieving the loss of a loved one to substance abuse meet every Wednesday from 7:30 to 9:30 p.m. in Beaconsfield. To register, call 514-898-1220 or email graspmontreal@hotmail.com or visit grasphelp.org.

LGBTQ2+ Adult & Seniors supper open to adult and seniors who are questioning their gender identity or sexual orientation every Thursday from 4 to 8 p.m. at Beaconsfield United Church, 202 Woodside Ave. Visit http://www.lgbtq2centre.com.

Al-Anon Family Groups. Compassionate help for family and friends of alcoholics. If you are troubled by someone elses drinking you can find help and hope in a friendly, supportive atmosphere. Call 514-866-9803, email aisarea88english@gmail.com or visit alanonalateenqcouest.org.

Adult ADHD Support Group West Island. For adults and their loved ones who have ADHD. They meet every second Thursday at 7:45 p.m. Call 514-773-9815 or email adultadhd.wi@gmail.com.

TOPS (Take Off Pounds Sensibly)is a low-cost non-profit organization that helps with weight-loss support. They meet every Wednesday at 7 p.m. at Cedar Park Chalet, 20 Robinsdale Ave., in Pointe-Claire. Visit tops.org.

West Island Cancer Wellness Centre. Compassionate support and programs such as yoga, massage therapy, counselling, and more. They work with your health care professionals to improve your well-being and their services help you manage the emotional and physical challenges that come from a cancer diagnosis. Open Monday to Friday from 8:30 a.m. to 4 p.m., except on Wednesdays until 8 p.m. at 115 Du Barry St. in Kirkland. All services are free. Visit wicwc.org or call 514-695-9355.

Gamblers Anonymousoffers help to anyone suffering from a gambling problem. Call 514-484-6666 or visitgamontreal.ca.

The Montreal Chapter of the Canadian Aviation Historical Society meets on March 19 at 11 a.m. at the Pointe-Claire Legion Hall, 365 St. Louis St. Viswanath (Vis) Tata will speak on CRJ 7001 the Untold Story. Cost: $5 includes light lunch. Call 450-463-1998.

The More You Know: Mangez local au rythme des saisons. With nutritionist and author Julie Aub who will discuss the advantages of eating food produced locally from Quebec all year round. Presented in French with bilingual question period on March 14 at 2 p.m. at the Dorval Library, 1401 Lakeshore Drive. Free. Call 514-633-4170.

Yoga for Your Face with Carole Morency on March 18 from 7 to 8:30 p.m. at the Pointe-Claire Public Library, 100 Douglas Shand Ave. Rejuvenate your face by strengthening and relaxing facial muscles through a series of small but specific movements. Free, but passes required. Call 514-630-1218.

Club Cycliste Beaconsfield. Season opener meeting for avid cyclists on March 27 at 7 p.m. at Holleuffer Chalet, 75 Charlevoix St. in Kirkland. This club is a volunteer run, non-profit organization composed of avid recreational cyclists in the West Island. An overview of upcoming activities for existing and new members (or interested parties) will be given. All West-Island road cyclists welcome. Visit clubcycliste.com.

Kirkland 55+ Club for seniors offers contract bridge sessions (no partner needed) every Sunday from 1 to 4 p.m. at 16950A Hymus Blvd. in Kirkland. They also offer duplicate bridge sessions (with partners) every Wednesday afternoon from 1 to 4 p.m. Cost: $4, $2 for members. Call 514-694-2435 or email haeri@videotron.ca.

Senior Mens Contract Bridge Club every Tuesday from 1 to 4 p.m. at the Edwin-Crawford Residence, 35 Maywood Ave. in Pointe-Claire. Cost: $5. No partner or commitment required. Call 514-697-4159.

Lakeshore Creative Stitchery Guild meets every Thursday from 9:30 a.m. to 3 p.m. and alternating Tuesdays from 7 to 10 p.m. at the Centre Nol Legault, 245 Lakeshore Rd. in Pointe-Claire. Visitors and beginners welcome. Visit lcsg-gtal.ca.

Rummage sale on Wednesday from 10 a.m. to noon at St. Johns United Church, 98 Aurora Ave. in Pointe-Claire.

Lenten lunches every Wednesday (until April 8) from 11:30 a.m. to 1 p.m. at Christ Church Beaurepaire, 455 Church St. in Beaconsfield. Cost: $8 includes homemade soup, bread, cheese, dessert, tea and coffee. Call 514-697-2204.

Book, bake and craft sale on Saturday from 10 a.m. to 1:30 p.m. at Valois United Church, 70 Belmont Ave. in Pointe-Claire.

Boutique 24 Thrift Shop is open every Thursday from 11:30 a.m. to 3:30 p.m. and the last Friday of each month from 6 to 9 p.m. at Union Church, Adair Hall, 24 Maple Ave. in Ste-Anne-de-Bellevue. Donations welcome. Call 514-713-5054.

Thrift Shops for NOVAoffer clothing for the whole family, footwear, books, household items, jewelry, etc. Thrift shop and used book shop,43 Ste-Anne St. in Ste-Anne-de-Bellevue. Call 514-457-1642.Thrift shopat 2750 St-Charles Blvd. in Kirkland. Call 514-697-6692.Furniture and Used Book Thrift Shop,449 Beaconsfield Blvd. in Beaconsfield. Call 514-694-8417.Boutique NOVA in Plaza Pointe-Claire.Boutique NOVA Hudson, 455 Main Rd. and a second new location 538 Main Rd. in Hudson. Call 450-202-6682.All are open from Tuesday to Sunday from 10 a.m. to 4 p.m. Donations welcome. Visitthriftshopsfornova.com.

The Teapot 50+ Centre, 2901 St-Joseph Blvd. in Lachine, needs volunteers to help out at their upcoming St. Pats Pub afternoon on March 18 from 10 a.m. to 4 p.m. Tasks include setting up the room, helping with food prep, serving and clean-up. This event provides members with the opportunity to socialize, celebrate and share a pint or two in a friendly, safe environment. Call 514-637-5627 or theresag@theteapot.org.

ABOVAS a non-profit organization that offers accompanied-transport for West Island residents going to medical appointments on the island of Montreal. If you need assistance and would like to use this service, or if you have a few hours to offer with access to a car and would like to volunteer, email info@abovas.com or call 514-694-3838, or visit abovas.com.

Volunteer West Islandmatches you with volunteer opportunities that suit your interests in the West Island. Visitcabvwi.org or call 514-457-5445, ext. 226. They are currently looking for the following:

Volunteer West Island is looking for Meals on Wheels volunteers for the Pierrefonds and Roxboro kitchens, two cooks for Pierrefonds as well as clean up help in Roxboro, Dorval and Ste-Anne-de-Bellevue. Ages 18+.

Volunteer West Island coordinates the Income tax assistance service offered at several West Island locations. We are looking for a receptionist for our Valois location, two half days per week for six weeks. Tasks include booking appointments and managing the flow of clients through the centre. 18 and up

The Low-Vision Self-Help Association, which meets the second Wednesday of each month in Beaconsfield, is looking for two volunteer drivers to bring members to the meeting, as well a volunteer to help with setting up the snack and the rooms tables & chairs. Ages 16+.

The Nova Adult Day Centre is always in need of volunteers to share time with a lovely group of adults through physical, sensory, reminiscence activities as well as music and song, dance, arts & craft, gaming, exercise, baking and pet therapy or any other topic that you would like to offer. The centre operates Tuesday to Friday from 9 a.m. to 2 p.m. Lunch provided. Minimum age: 18 years.

CROM, a rehabilitation centre for adults and children living with intellectual disabilities, autism spectrum disorders and/or physical disabilities, is looking for English or French speaking volunteers. They must be energetic, creative and fun and enjoy arts and crafts, games, homework help, to support parents with young children in their homes. Visits are 2 hours and can take place weekly or biweekly. Ages 18+.

Several West Island seniors residences are looking for friendly visitors for clients who have no family close by it makes a world of difference in their lives. Also needed are volunteers to help run the group activities with the recreation technician. Ages 16+.

West Island Citizen Advocacyis a Centraide/WICS community organization that matches those in need with volunteer advocates. Call 514-694-5850 or visit volunteerwica.com. They need:

A Dollard resident in her early 90s who loves plants would like to share some time with a female volunteer. She speaks Mauritian Creole and Hakka, as well as limited French. She is autonomous although has some trouble with mobility due to arthritis. She is very kind and enjoys socializing and would love to have a friendly visitor for a cup of coffee or tea. When weather is nice she would enjoy a walk to the nearby park or enjoy the fresh air in her backyard garden.

A Pointe-Claire lady in her 70s with some mobility problems would love the company of a female volunteer for some social support. She speaks French and English, loves swimming, dancing and using the treadmill. She has access to all these facilities but would love to be accompanied by someone. She is a very pleasant person to spend time with.

A friendly and sociable automotive engineer who lives in le-Bizardwould appreciate spending some time with a volunteer who can help him become more familiar with social media and using his computer. He is in his early 70, he speaks English and German, and he is very autonomous.

An English-speaking Pierrefonds lady in her late 70s would like a female volunteer to accompany her shopping this summer once a month. She is in a wheelchair but uses adapted taxi for transportation and the volunteer can accompany her in the taxi to and from the shop.

Go here to see the original:
West Island Community Calendar for the week of March 11 - Montreal Gazette

There are significant clinical differences and outcomes between patients with systemic sclerosis (SSc)-mixed connective tissue disease (MCTD), SSc-overlap, and SSc-only, according to research results published in Arthritis Care and Research. Study investigators indicated better survival among patients with SSc-MCTD and SSc-overlap than among those with SSc-only.

Mixed connective tissue disease is defined by the presence of anti-ribonucleoprotein complex (RNP) antibody with >3 clinical features, including swollen fingers, synovitis, myositis, Raynaud phenomenon, or acrosclerosis. Patients diagnosed with SSc and with features of connective tissue diseases are typically classified as SSc-overlap.

To describe the clinical characteristics and outcomes of SSc-MCTD and SSc-overlap, 1728 patients (86% women; 95% white) from the Australian Scleroderma Cohort Study who met the American College of Rheumatology/European League Against Rheumatism criteria for SSc were enrolled in the study. A total of 5.6% (n=97) of patients were indicated to have both SSc and MCTD (SSc-MCTD), while 7.3% (n=126) were indicated to have SSc-overlap syndrome.

Researchers created 3 mutually exclusive groups, including SSc-MCTD (n=97), SSc-overlap (n=126), and SSc-only (consisting of the remaining 1505 patients). Mean duration of follow-up was similar between groups at approximately 4.5 years. Researchers performed univariate comparison of clinical features between groups using analysis of variance or chi-square, and conducted survival analysis using Kaplan-Meier curves and Cox regression.

Results of the study indicated that among patients with SSc-overlap, 38.9% had overlap with rheumatoid arthritis, 34.1% with Sjogren syndrome, 13.5% with systemic lupus erythematous, 17.5% with polymyositis, and 2.4% with dermatomyositis. Compared with patients in the SSc-overlap and SSc-only groups, patients with SSc-MCTD group were younger at disease onset (46.5 and 46.8 years vs 38.4 years, respectively; P <.0001). Patients in the SSc-MCTD or SSc-overlap groups were more likely than patients in the SSc-only group to have other positive autoantibodies, including anti-Ro, anti-La, anti-Jo-1, and antineutrophil cytoplasmic antibodies. Patients in the SSc-MCTD and the SSc-overlap groups had similar frequency of interstitial lung disease (ILD), whereas those in the group with SSc-MCTD had higher frequency of pulmonary arterial hypertension (PAH; 12.4% vs 4.8% and 11.1% in the SSc-overlap and SSc-only groups, respectively; P =.0751). Synovitis and myositis were equally common in the SSc-overlap and SSc-MCTD groups.

Patients with SSc-overlap were significantly more likely to have experienced dysphagia (60.3% vs 45.4% of SSc-MCTD vs 45.5% of SSc-only; P =.0006). Compared with patients in the SSc-only group, those in the SSc-MCTD and SSc-overlap groups had a higher likelihood of exposure to immunosuppressive treatment, including prednisolone and disease-modifying antirheumatic drugs.

Kaplan-Meier curves showed better survival in the SSc-MCTD group compared with patients in the SSc-overlap or the SSc-only groups (P =.011); however, scleroderma-specific antibodies that were more reliable indicators of survival indicated that antinuclear antibody-centromere or anti-RNP conferred consistently better survival than anti-topoisomerase 1 (Scl)-70 or anti-RNA polymerase 3. Researchers noted that compared with patients with SSc-only, those with SSc-MCTD or SSc-overlap had lower all-cause mortality after ILD and PAH diagnosis (P =.024). Overall, compared with SSc-only, SSc-MCTD and SSc-overlap groups combined had significantly better survival (P =.019).

Study limitations included survivor bias, retrospective analysis, and a small SSc-MCTD sample size for the subgroup analysis.

This study provides insights into the clinical characteristics of patients with SSc-MCTD, SSc overlap, and SSc-only, and shows that anti-RNP antibodies are associated with better survival than anti-Scl-70 and anti-RNA polymerase [3] antibodies, the researchers concluded.

Disclosure: Several study authors declared affiliations with the pharmaceutical industry. Please see the original reference for a full list of authors disclosures.

Reference

Fairley JL, Hansen D, Proudman S, Sahhar J, Ngian GS, Walker J. Clinical characteristics and survival in systemic sclerosis-mixed connective tissue disease and systemic sclerosis-overlap syndrome [published online February 14, 2020]. Arthritis Care Res. doi:10.1002/acr.24167

Read the original post:
Better Survival in Patients With SSc-Mixed Connective Tissue Disease and SSc-Overlap vs SSc-Only - Rheumatology Advisor

Libby Smith should be looking forward to her school prom and preparing to take her GCSEs.

Instead, she feels "trapped" in the body of an 80-year-old and needs two knee cap replacements, thanks to a rare form of juvenile arthritis

According to YorkshireLive , the 16-year-old is constantly in pain from juvenile idiopathic arthritis (JIA), so bad that she has considered undergoing a risky bone marrow transplant in an attempt to 're-set' her immune system.

The condition targets Libby's cartilage, making even the simplest of tasks difficult to complete.

Walking, cutting up food and even brushing her hair are now impossible for Libby- she has to rely on her parents Diane Smith, 40, and Adrian Smith, 45, for help.

JIA is an inflammation of one or more joints in a child under the age of 16 years.

Juvenile means that the child was under 16 when the arthritis started, idiopathic means there is no other explanation for the inflammation in their joints and arthritis means that there is swelling and inflammation in the childs joints.

The child's immune system becomes over-active or poorly controlled.

As a result, it starts to attack the lining of the joint which causes inflammation and swelling. Infection can also be a trigger.

Can be more likely in children with a family history of rheumatoid arthritis or lupus.

Information taken from National Rheumatoid Arthritis Society

The teen wanted to become a professional dancer or swimmer, but her dreams were snatched from her when she was first diagnosed with the condition at just 5 years old.

Libby has suffered with mobility issues, having to undergo a lot of surgeries in her lifetime- including a fusion surgery on her right foot, and having an Ilizarov leg brace fitted; she also needs two knee replacements.

Libby is forced to hobble around her home, 'shuffle' downstairs on her bum and has to go out in a wheelchair as her wrists are too weak to use crutches.

The teen, from West Yorkshire, said: "It feels like I'm trapped in an older person's body, I feel like I'm in a hole that I can't get out of.

"I'm waiting for operations to make life easier that are associated more with grandparents - people in their 70s and 80s - rather than my own age.

"I'm upset all the time and I struggle to sleep at night.It's like constant shooting pains that burn, I just want the knee replacement done as soon as possible.

"I've not completed a single day of highschool and struggled with friends as I think people just don't understand.

"It's been really isolating not going to school.It's been frustrating going through this, you get your hopes up that people with JIA grow out of it but I think it just got worse."

Some people with JIA grow out of' the condition, but Libby has not been so lucky and her health continues to deteriorate.

Mum, Diane, says watching Libby's health continue to deteriorate is "breaking her heart" and she turned to social media for answers and support.

The diet consultant said that Libby had always complained of aching legs but only got a official diagnosis in 2011 after Adrian insisted on taking her to A&E when the tot avoided putting any weight on her right leg.

Diane said: "Libby was absolutely fine as a baby but as she got older she would say to me 'I can't walk' and would say her legs were aching all the time.

"She would complain all the time, we just thought she was downright lazy.

"As she was our first child we didn't have anything to compare her to, we just thought that she had little legs and was tired.

"One Sunday when she was five she hopped round on her left leg all day. Adrian told me to pack a bag and that he was taking her to A&E.

"I told him we couldn't take her there as it wasn't an accident or an emergency but he insisted if she couldn't walk he was taking her."

After a week of blood tests and x-rays, Libby finally received her diagnosis of JIA.

Diane said: "We were told it was a childhood condition that she should grow out of in her teens as she goes through puberty.

"They said if she didn't grow out of it then she would probably grow out of it when she had her first baby because things change with hormones.

"She was measured up for crutches, a wheelchair and a walking frame and had physio organised.

"The only history we have of it in our family is with older people, like everyone's family, nan and grandad had it a bit.

"Felicity (Libby's 10-year-old sister) is the complete opposite of Libby, she's the most active child in the country so we knew there was no problem there.

"If we'd had Felicity first and knew how active a child should be, we would have realised there was something wrong with Libby a lot sooner."

Libby's arthritis only worsened as she got older, leaving her unable to attend secondary school- instead, she battled through the pain to study with tutors at home.

Diane said: "She missed her whole high school life because she was so poorly - since leaving junior school her condition got worse and worse.

"We've had English and maths tutors at home but some days I'd have to turn the tutor round at the door and say she wasn't well enough.

"Some days she would manage an hour and other days she could do two, but not very often."

The teen's physical limitations and absence from school means Libby cannot sit her GCSEs.

However, Diane and business owner Adrian encouraged her passion for make-up and she set up her own make-up artist business last year.

Diane said: "Libby's not able to sit her GCSEs as she's missed far too much school because she just wasn't well enough.

"As parents we've been realistic and thought about what she would be able to do as an adult.

"Libby is really good at make-up artist work so we set up a business for her and recently swapped her English and maths tutors for make-up artist tutors.

"She's had a few clients but since Christmas she's just not been well enough, so we've had to put the business on hold."

Libby is on a lot of medication and has undergone a lot of surgeries to combat her painful symptoms- but none of the treatments appear to be working in the long term.

Business owner, Adrian said: "The consultants describe Libby as 'not following the script'.

"Instead of her body accepting medicines that have been successful for other people, it rejects it.

"Libby was looking into a bone marrow transplant to re-set her immune system not so long ago because they were running out of ideas as far as treating it with normal medications.

"The doctors were very blunt about the risks and said she might not make it, there was a substantial percentage that we'd lose her.

"It wasn't because of the procedure, but because of the bacterial medication she's on that increases the risk of her not coming through the re-setting of her immune system.

"We were on the last family of medicines before Christmas and it started working so she decided she wouldn't go ahead with it."

The family are desperately searching for a medicine or treatment that can help Libby's condition.

Adrian said: "This condition is something you associate with someone who's a lot older - she's having to face issues that 80-year-olds face at the age of 16.

"She hobbles around the house, going up and down stairs she does on her bum."When she walks it's more like a shuffle, a move that older people do, and when we go out she has to use the wheelchair.

"She used to be able to brush her hair but we have to do it now, we also cut her meat up for her before she can eat.

"All these other kids her age are off on school trips and going out with friends after school but Libby can't do that.

"As parents we try and do what we can to spend time with her and make her laugh.

"I've said all along that if there was something overseas I would pay for it, we just want answers.

"Sod the funding, if it makes me bankrupt, I'll pay for it."

Continue reading here:
Teenager with rare juvenile arthritis 'feels trapped' in the body of an 80-year-old - Gloucestershire Live

A decade-old drug used to treat inflammation in arthritis patients could be the answer to the world's fears of the coronavirus.

Actemra, an anti-inflammation drug made by Swiss drugmaker Roche, has been approved by the Chinese government to treat severe coronavirus symptoms. This comes at a time when countries around the world are desperately searching for ways to combat the deadly infection.

The Swiss drug maker donated nearly $2 million worth of Actemra to China, its local operations said in a blog post on Monday.

According to reports, 14 serious and critically ill patients treated with existing medicines at a hospital affiliated with the University of Science and Technology of China (USTC) showed positive results.

Since Actemra's approval a decade ago, it has become the go-to drug for inflammatory conditions, including cytokine storms in cancer patients receiving cell therapy.

The Swiss company, for which China is its No. 2 market behind the United States, is also making diagnostic gear to detect the coronavirus.

Currently, there is no published clinical trial data on the drug's safety or efficacy against the virus.

More than 3,000 people have died and 93,000 have been infected by the novel coronavirus thought to have originated in Wuhan, China, before spreading to around 90 countries including the United States, Italy, Switzerland, France and Germany, and India.

Read the original here:
Coronavirus medicine: An arthritis drug could be the answer everyone is looking for - Economic Times

Scorpion venom could be used to manage arthritis symptoms in the future, according to new research published in the journal Science Translational Medicine.

Scientists suggest that a protein present in scorpion venom could help alleviate the harmful side effects of steroids used to treat arthritis.

Testing on mice, US researchers found this protein rapidly accumulates in joint cartilages, including the knees, ankles, hips, shoulders and spinal discs. They combined these proteins, known as cystine-dense peptides (CDPs), with a steroid normally used to treat rheumatoid arthritis to create a drug delivery system that targeted only the joints and not the rest of the body.

They found that this method reversed joint inflammation in the rodents, while avoiding steroid exposure to other parts of the body.

A 'safer way' to treat arthritis

The team hope that the findings will help a lot of people, providing a 'safer way' to treat the some 10 million sufferers of arthritic diseases in the UK, and 54 million in the US.

While steroids are used to treat inflammation that causes arthritis, they come with dangerous side effects, including weakening of the bones, high blood pressure and increased risk of infections, which is why they cannot be administered for long periods of time.

Dr Jim Olson, of the Fred Hutchinson Cancer Research Centre in Seattle, US, and the senior scientist in the project, said, For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself.

Steroids like to go everywhere in the body except where theyre needed most. This is a strategy to improve arthritis relief with minimal systemic side effects.

The researchers looked at cystine-dense peptides (CDPs), a chemically diverse family of proteins found in the venom of scorpions, spiders and snakes.

Treatment reversed inflammation in the joints without damaging tissue

After analysing 42 CDPs from 20 species, they identified one candidate that accumulated within cartilage tissue in rodents.

The scientists then attached these proteins to triamcinolone acetonide, a steroid treatment for arthritis, and found that it helped concentrate the steroid drug within the cartilage of joints in rats with rheumatoid arthritis.

In rheumatoid arthritis, the body's immune system targets affected joints, which leads to pain and swelling.

The treatment was found to reverse inflammation in the joints without damaging tissues in the thymus and spleen, the two organs often affected by repeated steroid treatments.

Researchers say further studies are required to assess the safety of this drug delivery method in animals over longer periods of time before moving on to human clinical trials.

Emily Girard, staff scientist in Dr Olsons laboratory and one of the studys lead authors, said, "There is more development to be done, but I hope that this work results in a therapeutic that will help a lot of people."

More here:
Scorpion venom might be the answer to treating arthritis - here's how it works - Lancashire Post

Scorpion venom could mitigate the risks of steroids (Jamras Lamyai / EyeEm Provider: Getty Images)

The key to managing arthritis may be found in scorpion venom.

In a roundabout way, the venom could be used to help elderly people and others suffering with the disease.

Scientists suggest that a protein present in scorpion venom could help mitigate the harmful side effects of steroids used to treat arthritis.

Researchers in the US have found this protein rapidly accumulates in joint cartilages, including the knees, ankles, hips, shoulders, and spinal discs, when administered on mice.

The team combined these proteins, known as cystine-dense peptides (CDPs), with a steroid normally used to treat rheumatoid arthritis to create a drug delivery system that targeted only the joints and not the rest of the body.

They found that this method reversed joint inflammation in the rodents, while avoiding steroid exposure to other parts of the body.

The researchers believe their drug delivery method could be a safer way to treat arthritic diseases, which affect more than 10 million people in the UK.

While steroids are used to treat inflammation that causes arthritis, they come with dangerous side effects, including weakening of the bones, high blood pressure and increased risk of infections, which is why they cannot be administered for long periods of time.

Dr Jim Olson, of the Fred Hutchinson Cancer Research Centre in Seattle, US, and the senior scientist in the project, said: For people with multi-joint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself.

Steroids like to go everywhere in the body except where theyre needed most. This is a strategy to improve arthritis relief with minimal systemic side effects.

The researchers looked at CDPs, a chemically diverse family of proteins found in the venom of scorpions, spiders and snakes. After analysing 42 CDPs from 20 species, they identified one candidate that accumulated within cartilage tissue in rodents.

The scientists then attached these proteins to triamcinolone acetonide, a steroid treatment for arthritis, and found that it helped concentrate the steroid drug within the cartilage of joints in rats with rheumatoid arthritis.

The treatment was found to reverse inflammation in the joints without damaging tissues in the thymus and spleen, the two organs often affected by repeated steroid treatments.

Researchers say further studies are required to assess the safety of this drug delivery method in animals over longer periods of time before moving on to human clinical trials.

Emily Girard, staff scientist in Dr Olsons laboratory and one of the studys lead authors, said: There is more development to be done, but I hope that this work results in a therapeutic that will help a lot of people.

The findings are published in the journal Science Translational Medicine.

Read the original:
Hope for better arthritis treatment could be found in scorpion venom - Metro.co.uk

They mightn't seem like the most obvious places to look, but the venom of deadly creatures like spiders, snakes and scorpions are an increasingly rich source of medicines for human health. The latest example of this comes from scientists at Fred Hutchinson Cancer Research Center, who have discovered a tiny protein in scorpion venom that could become part of a potent new treatment for arthritis.

While drugs exist to treat inflammation in sufferers of arthritis, a scattergun approach means that the often bring severe side effects. These types of non-targeted steroid treatments sweep through the whole body and while they can act swiftly to relieve inflammation, they can also cause high blood pressure or weight gain, and make it harder for diabetics to manage their condition, to list a few examples.

For people with multijoint arthritis, the side effects of controlling the disease can be as bad or worse than the disease itself, says Dr. Jim Olson, who led the new research. Steroids like to go everywhere in the body except where theyre needed most. This is a strategy to improve arthritis relief with minimal systemic side effects.

This strategy Olson speaks of is the product of more than a decade of toiling away in the lab, searching for proteins in scorpion venom that can be used as the basis for advanced drugs to treat various ailments. Around four years ago while screening dozens of peptides from the venom of scorpions and spiders, he and his team found one that seemed to naturally buildup in the cartilage.

This struck the scientists instantly as a potential way to develop more targeted treatments for arthritis. This led to years of trial and error and more tinkering in the lab, until the researchers came up with a recipe that appears to have the desired effect. It involved pairing this peptide with a steroid called triamcinolone acetonide, a combination that was then tested in rats where it proved capable of concentrating in the joints and reversing inflammation in rats with arthritis. And crucially, it produced no detectable side effects.

Its a pretty simple idea to take a mini-protein that naturally goes to cartilage and attach something to it so that you get targeted delivery of the drug, but it was challenging to accomplish, said Emily Girard, a staff scientist in Olsons lab. We had to learn and adapt the behavior of the mini-protein, the chemical linker and the steroid payload to make a product that would go to cartilage, stay as long as we needed it to, release the drug at the right rate, and have a local but not systemic effect. There is more development to be done, but I hope that this work results in a therapeutic that will help a lot of people.

The scientists note that the treatment is still years away from entering clinical use, but describe the proof of concept as "promising."

The team's research was published in the journal Science Translational Medicine.

Source: Fred Hutchinson Cancer Research Center

Read the rest here:
Scorpion venom protein reverses inflammation in rats with arthritis - New Atlas

Why do microbes kill some people but not others? This is the hardest question in all of medical microbiology. The reason it's so hard is because the answer depends not just on the microbe in question but also on the person.

Sometimes, it's because the microbe is particularly nasty. No matter how healthy a person is, smallpox, HIV, Ebola, cholera, and plague all wreak havoc on the human body.

But that's not the case for all microbes. Billions of people get scratched every year, but only a handful will develop an infection with a flesh-eating bacterium. Millions of people go swimming in lakes every year, but only a handful will become infected with a brain-eating parasite. Why? Is it simply "wrong place, wrong time," or is there a more sophisticated answer?

Increasingly, the latter appears to be true. As a case-in-point, scientists discovered that a single mutation (i.e., a single letter change in our 3-billion-letter genome) may have doubled a person's risk of becoming infected with the 2009 pandemic strain of influenza. In other words, an individual's genetics -- particularly when it comes to genes involved with the immune system (as was the case in the flu research) -- may be just as much to blame as the microbe's genetics.

How an Arthritis Drug Could Treat Coronavirus Infections

An effective immune response must be of the proper strength and directed at an appropriate target. If these two criteria aren't met, bad things can happen, such as autoimmune disease or a lethal over-reaction to a peanut. The same is true when the immune system targets a dangerous microbe. The response must not be too weak or too strong. If it's too weak, the microbe will overcome the body; if it's too strong, the body can suffer from collateral damage.

One way collateral damage can occur is when the immune system sends out too many pro-inflammatory signals. The immune system is constantly "talking" to other parts of the immune system using chemical messengers known as cytokines. Some encourage inflammation, others discourage it. If too many pro-inflammatory cytokines, such as one called interleukin-6 (IL-6) are released, a "cytokine storm" is said to have developed.

Typically, IL-6 is deployed in order to elicit a quick response to infection and tissue injury. But if too much is produced, the entire body can undergo an inflammatory response, which can be lethal if it leads to multiple organ failure. Ultimately, it's this sort of system-wide immunological overreaction that causes people to die from septic shock. It may also be responsible for some of the deaths due to influenza and SARS.

Something similar may be happening with people who become infected with the Wuhan coronavirus and develop the disease now known as COVID-19. Perhaps they have an immunogenetic profile that, for some reason, overreacts to the virus. Thus, a drug that targets IL-6 could, in theory, help block an overreactive immune response.

And that's precisely what China has just discovered. An antibody drug that blocks IL-6 receptors (called Actemra or tocilizumab) has shown promise in treating patients in Chinese clinics. FiercePharma explains that this drug was approved by the FDA in 2017 to treat cytokine storms and in 2010 to treat rheumatoid arthritis, an autoimmune condition. What causes that? You guessed it: Too much IL-6.

Let's hope this drug helps save some lives.

See the original post here:
How an Arthritis Drug Could Treat Coronavirus Infections - American Council on Science and Health

Higher levels of consumption of ultra-processed food in patients with rheumatoid arthritis (RA) have been associated with worse metabolic profiles and elevated cardiovascular risk, while higher levels of consumption of unprocessed or minimally processed foods are associated with lower low density lipoprotein (LDL) cholesterol and reduced 10-year cardiovascular disease risk, according to study results published in Clinical Rheumatology.

To assess the associations between processed food consumption and risk factors for cardiovascular disease in patients with RA, investigators in Sao Paulo, Brazil, conducted a cross-sectional study with 56 women (aged 62.57.9 years; body mass index, 28.45.1 kg/m2) focused on evaluation of food consumption according to level of processing (eg, unprocessed or minimally processed, processed, and ultra-processed) and associated levels of consumption of processed foods with risk factors for cardiovascular disease.

Unprocessed or minimally processed was the most prevalent food processing level in the study participants (42.612.6% of total energy intake [TEI]), followed by processed (24.211.9% TEI), ultra processed (18.111.8% TEI), and culinary ingredients (15.16.4% TEI). Adjusted regression models showed a negative association between higher consumption of unprocessed or minimally processed foods and Framingham risk score (=-0.07 [95% CI, -0.14 to -0.006]; P =.034), 10-year risk of developing cardiovascular disease ( =-0.07 [95% CI, -0.12 to -0.02]; P =.013) and LDL (=-1.09 [95% CI, -1.94 to -0.24]; P =.014). A positive association was found between higher consumption of ultra processed foods and glycated hemoglobin (=0.04 [95% CI, 0.01-0.07]; P =.013). After adjustments were made for age and body mass index, the association between unprocessed or minimally processed foods and Framingham risk score was no longer significant. In contrast, after adjustments, the association between higher consumption of ultra processed foods and Framingham risk score became significant (=0.06 [95% CI, 0.001-0.11]; P =.045).

Study investigators concluded, Patients with RA consuming more ultra-processed foods showed higher glycated hemoglobin and Framingham risk score, whereas those consuming more unprocessed or minimally processed foods had lower 10-year risk of developing cardiovascular disease and LDL. A food pattern characterized by a high ultra-processed food consumption emerges as a novel, modifiable risk factor for cardiovascular diseases in RA. Prospective, controlled studies should address this hypothesis.

Reference

Smaira FI, Mazzolani BC, Peanha T, et al. Ultra-processed food consumption associates with higher cardiovascular risk in rheumatoid arthritis [published online January 4, 2020]. Clin Rheumatol. doi:10.1007/s10067-019-04916-4

This article originally appeared on Rheumatology Advisor

Read more:
Ultra-Processed Food Consumption Linked to Cardiovascular Risk in RA - The Cardiology Advisor

More News08 Mar 2020 | 4:31 PM

Puducherry, Mar 8 (UNI) Mr M Sankaranarayanan, Managing Director, The Grand Technologies and Founder-cum-Chairman of Aathmalayaa School, Karaikal has been elected as the Chairman of Confederation of Indian Industry (CII), Puducherry State Council for the financial year 2020-21.

Ahmedabad, Mar 8 (UNI) Jewelry sector expert and the Chairman and Managing Director (CMD) of Headway Business Solutions LLP, Gujarat based company in to consultancy, coaching and mentoring for jewelry sector business development, Paresh Rajpara on Sunday said that the biggest challenge in the gems and jewelry sector in India was the gold price volatility.

BEIJING, March 8, 2020 /PRNewswire/ -- Forty-eight hours ahead of schedule, Sinopec Corp, China's leading energy and chemical company, put its first melt-blown non-woven fabric assembly line into operation at its Yanshan factory in Beijing on March 6. The Yanshan factory is a converted 3600 square meter old warehouse that has found new life as a global production base following the challenges brought by the coronavirus outbreak.

NEW DELHI, India, March 7, 2020 /PRNewswire/ -- IPM India Wholesale Trading Private Ltd (IPM India), a country affiliate of Philip Morris International Incorporation (PMI), has announced that it has set an aim to achieve as much as 40% equal gender representation in management roles in the company by 2022. A more focused journey began for IPM India in 2015 with the introduction of target Gender Representation KPIs. The company took a firm decision to take up the gender representation KPI from 18 percent in 2015 to 40 percent by 2022.

Kolkata, Mar 07 (UNI) Abhijit Roy, Managing Director and CEO of Berger Paints India Ltd., has been elected as the chairman of CII Eastern Region for 2020 21.

See the rest here:
Rising arthritis: Shalby hospital to come up in UP - United News of India

Editors Note: Sponsored content brought to you by Panorama Summit Orthopedics

Shoulder pain can range from temporary to long-lasting, from motion-related to constant, but one of the most disruptive symptoms of any shoulder injury is its effect on sleep.

When you dont sleep, everything in life becomes harder, said Dr. Aaron Black, a shoulder, knee and trauma specialist at Panorama Summit Orthopedics.

Some of the most common sources of shoulder pain include rotator cuff injuries and arthritis. In Summit County, its common to see patients who develop shoulder arthritis as a result of previous injuries to the shoulder, such as a shoulder dislocation earlier in life, Dr. Black said.

A specific diagnosis and treatment plan can result in years or perhaps a lifetime of pain relief and increased mobility in this important joint. Its Dr. Blacks mission to make sure hes helping patients not only eliminate shoulder pain and weakness, but also get back to consistently healthy and restful sleep.

Primary arthritis vs. rotator cuff arthropathy

The two broad categories of arthritis most commonly seen in Summit County are primary arthritis and rotator cuff arthropathy, or secondary arthritis. Primary arthritis has no specifically known cause and is usually related to age, sex and genes, according to the Arthritis Foundation. Rotator cuff arthropathy happens after a large, long-standing rotator cuff tendon tear that no longer holds the head of the humerus in the socket, causing it to move upward and damage the surface of the bones, according to the American Academy of Orthopaedic Surgeons.

Shoulder arthritis is experienced as achy pain and stiffness around the shoulder that often feels worse in the morning, Dr. Black said. Rotator cuff arthropathy is usually associated with stiffness and weakness.

Nonoperative arthritis treatment

Nonoperative shoulder arthritis treatment includes physical therapy and injection therapies.

As with any arthritic joint, the more you use it, the less stiff it is and the less pain you have, Dr. Black said.

PT can help improve range of motion in the shoulder, while icing the shoulder two or three times a day can reduce inflammation and ease pain.

Dr. Blacks injection therapy options include cortisone and biologic agents, such as platelet-rich plasma (PRP), all of which act primarily as anti-inflammatories.

No biologic injection therapies contain stem cells for tendons or cartilage, despite advertisements to the contrary, and thus do not regrow cartilage or tendons, he said.

Cortisone injections can offer pain relief for three to six months, while PRP tends to last a bit longer, Dr. Black said. The procedures are performed in the office under ultrasound guidance.

Shoulder joint replacement (arthroplasty)

If shoulder arthritis is severe, its less likely that the nonoperative options will get the job done. The next option for these patients would be shoulder joint replacement surgery.

Dr. Black said there are two types of shoulder replacements: anatomic total shoulder replacement and reverse total shoulder replacement. There are roughly 53,000 of these surgeries performed each year in the United States, according to the American Academy of Orthopaedic Surgeons.

Both procedures have differing benefits. Dr. Black said that anatomic replacements can be done on patients of any age, but those who have it at a younger age might require another surgery later in life. The procedure works well for getting patients back to their normal activities.

Reverse replacements are extremely reliable for reducing or eliminating pain, but less reliable for getting full range of motion back, he said.

I do all of my shoulder replacements with custom 3D modeling and patient-specific guides made to ensure the components are in exact right position, Dr. Black said.

Dr. Black stresses that all joint replacements are elective surgeries.

I will never tell a patient they have to have a joint replacement, he said. This is symptom-based when you say its time, its something Ill say you should have. I want all of my patients to be informed about the options.

Shoulder joint replacement recovery includes about six weeks in a sling, and in three to four months most patients are back to regular activity with continued improvement from there.

Rotator cuff injuries

Another common local shoulder affliction is to the rotator cuff, which is the combination of muscles and tendons that keep your arm bone centered in your shoulder socket to provide shoulder motion and stability. Dr. Black said these injuries can happen during a fall when the arm is thrown away from the body, but sometimes rotator cuff injuries are chronic and happen over time.

Some people even have large tears to the rotator cuff without ever feeling any symptoms.

The good news is that there are a lot of treatment options, from physical therapy and injections to repair or reconstruction surgery.

Read the original post:
Common sources of shoulder pain and how to treat it - Summit Daily News

CHICAGO About 54 million Americans suffer from the aches and pains of arthritis.

Treatments range from pain medications to injections to surgery.

None of it seemed to work for 77-year-old Marty Ciesielczyk.

And it jeopardized something he loved: jogging.

"For me, it's just enjoyable, and if you're not a runner, then you would have no idea what I'm talking about."

But Marty's active lifestyle was in jeopardy when knee pain took over.

"When you got to lay on the floor to get dressed, it's tough."

It happens when there's a loss of cartilage in the joint.

"It's like a tire, and as you slowly lose rubber on the tire, it wears away," explained Dr. Adam Yanke, a surgeon with Midwest Orthopaedics at Rush University.

"You might need to have the tire replaced at some point."

Marty's arthritis was too advanced for a scope procedure but not bad enough for a joint replacement.

So he enrolled in a study testing whether amniotic fluid, which surrounds a growing baby in the uterus, could help his pain.

"Amniotic products come from patients that are having healthy, elective C-sections, and they choose to donate these products at the time of the delivery," said Dr. Yanke.

It's thought to increase tissue healing and lower inflammation.

Doctor-diagnosed arthritisis more common in womenthan in men. Arthritis and other joint disorders are among the five most costly conditions among adults 18 and older.

Your bone marrow makes mesenchymal stem cells, or MSCs. They are known to grow into new tissues, including cartilage.

By gathering these cells and injecting them into the knee joint, the hope is that they will give growth to new cartilage and reduce inflammation.

Marty received a placebo during the study, but then chose to have the amniotic fluid when the study ended.

"I mean I didn't care if it was Pixie dust, as long as my knee was going to feel better."

He went from not being able to get dressed to jogging about a week after having the injection.

"This morning, I ran three, three miles, and I had no problem at all."

Amniotic fluid is also being used to treat ulcers in the eye.

Rush University will be enrolling patients for a larger follow-up study on amniotic fluid for joint pain in the future.

Clinical trialsare still going on and most studies are still early.

A review published in 2016 in BMC Musculoskeletal Disorders concluded that MSC-based therapies offer an "exciting possibility" for treatment, but further studies need to be done on how they can best be used and how well they work.

They are also known to be very expensive.

If this story has impacted your life or prompted you or someone you know to seek or change treatments, please let us know by contacting Jim Mertens atjim.mertens@wqad.comor Marjorie Bekaert Thomas atmthomas@ivanhoe.com.

Excerpt from:
YOUR HEALTH: Knee relief can be found in the womb - WQAD.com

Here are the top stories recently covered by DocWire News in the Rheumatology section. In this edition, read about what rheumatologists and patients believe is the most important in rheumatoid arthritis treatment, the effects of acute kidney injury on hip arthroplasty complications, the best technique for traumatic finger amputation, and seasonal effects on symptoms including fatigue on primary Sjgrens syndrome.

A new study assessed the preferences of patients and rheumatologists regarding treatment attributes for rheumatoid arthritis (RA) as well as their feelings regarding shared decision-making. Three steps were taken: literature review, RA patient focus group discussion, and rheumatologist focus group discussion. A total of 90 rheumatologists (mean years of experience, 18.1 years; 52.2% were female; average RA patients per week, 24.4) and 137 RA patients (mean age, 47.5 years; 84.0% were female; mean time since RA diagnosis, 14.2 years; mean time in treatment, 13.2 years) were included in the study. Although the top three attributes were the same between patients and rheumatologists, the order in which they were ranked differed, with patients placing the highest value on time with optimal quality of life (QoL) followed by mode of administration and time to onset of treatment action, compared to rheumatologists, who ranked the top three attributes as mode of administration, time with optimal QoL, and time to onset of treatment action.

A new study highlighted the effects of acute kidney injury (AKI) on complication risk in total hip arthroplasty (THA) patients. The study authors concluded that AKI significantly increases postoperative complication risks, including mortality, and recommend that increased focus be placed on reducing AKI risk. A total of 4.1 million primary THAs were performed during the study period, of which 61,077 (1.5%) included AKI during hospitalization. Unadjusted analyses unearthed a correlation between AKI and higher rate of complications and healthcare utilization. When adjusting for age, gender, race, income, underlying diagnosis, medical comorbidity, and insurance payer, AKI presenting in primary THA was significantly increased risks for implant infection, transfusion, revision, death, total hospital discharges above the median, discharge to a rehabilitation facility, and hospital length of stay longer than three days.

A new study examined whether season has an impact on symptoms of fatigue, pain, and dryness in primary Sjgrens syndrome. The present study evaluated patient data from the French nationwide multicenter pSS cohort Assessment of Systemic Signs and Evolution in Sjgrens Syndrome (ASSESS) (n=395). ASSESS was created in 2006 and houses five-year prospective follow-up data as well as data from three randomized, placebo-controlled trials of infliximab, rituximab, and hydroxychloroquine. In each study, visits included data collection on visual analog scale (VAS) scores for pain, fatigue, and dryness. Data were assessed by the day, month of the year, and season. VASs did not largely differ among the seasonal groups. The EULAR Sjgrens Syndrome Patient Reported Index scores did not significantly differ by season: spring, 57.7; summer, 59.5; fall, 55.9; and winter, 57.2.

A study questioned which is the best strategy to employ in traumatic finger amputations and concluded that the target technique will depend on the patient. The researchers reviewed data from a retrospective cohort study who underwent revision amputation or replantation at 19 U.S.- and Asia-based centers between Aug. 1, 2016, and April 12, 2018. The present analysis included data on 185 patients. The primary outcomes were hand strength, dexterity, hand-related quality of life, and pain, and the study authors employed a tree-based statistical learning method to obtain clinical decision rules for traumatic finger amputation treatment. Implementation of the tree-based statistical learning estimates found that different strategies were associated with different outcomes. Maximal hand dexterity or minimal patient-reported pain was obtained through replantation. Maximal hand strength was obtained through revision amputation in the case of a single-finger amputation; in all other cases, replantation was the best approach. Maximal patient-reported quality of life was obtained through revision amputation in patients with dominant hand injuries, and replantation was favorable in the case of nondominant hand injuries.

Read more here:
Rheum Round-up: Heres What Rheumatologists and Patients Value in Rheumatoid Arthritis Treatment, Plus How Kidney Injury Affects Surgery Complications...

captionGout is associated with frequent joint pain.sourceljubaphoto/Getty Images

Gout is an intensely painful form of arthritis that affects over 8 million Americans. As our diets change to include more processed foods, and with the increase in popularity of high protein diets, gout is on the rise, especially for older men. Heres what you need to know about the causes, symptoms, and treatment for gout.

Gout causes your joints to swell up and become extremely painful. Its the most common type of inflammatory arthritis and is caused by a buildup of uric acid, a waste product that is produced when your body breaks down a chemical called purine in certain foods.

Gout is caused by a condition called hyperuricemia, which means there is an excess of uric acid in the blood. Uric acid is normally diluted in your blood and leaves the body through your urine, but when you have too much uric acid in your blood, the acid can crystallize and build up in your joints, causing gout symptoms.

Foods with high concentrations of purines include red meat, alcohol, and fruit juices even if they are naturally sweetened. In addition, seafood like sardines, tuna, and shellfish also contain purine and should be eaten only in moderate amounts. Read our article on the best diets for gout for more information on what you should be eating and avoiding.

Western-style dietary patterns seem to increase the risk of gout, says Hyon K. Choi, MD, a professor of Medicine at Harvard Medical School. A typical Western diet includes large amounts of processed carbohydrates like high fructose corn syrup, red meat, and saturated fats.

Obesity may also be a risk factor: A study, published in Arthritis Care & Research in 2012, found that people who are obese are around twice as likely to suffer from gout compared with people whose body mass index falls in the normal range.

Other risk factors include sex and age. Men are more likely to develop gout, in general, and women are at greater risk after menopause.

Some people may only have gout attacks periods of acute pain and swelling in joints once or twice in their lifetime, while others with chronic gout may have frequent attacks, several times a year, that dont fully heal in between episodes.

Some of the most common symptoms of gout are:

The symptoms of gout usually come and go, says Choi, although patients can have chronic joint pain if the gout is severe or longstanding.

When you have an acute attack of gout, your doctor will likely focus on treating your immediate symptoms first by prescribing non-steroidal anti-inflammatory drugs to help bring down the pain and swelling. For patients who get frequent flares of gout, long-term treatment with a medication that lowers uric acid levels, such as allopurinol, is recommended, Choi says.

However, while symptoms of gout can be controlled with medications, it is also important to implement lifestyle changes, Choi says, adding that a good place to start is adopting a healthy diet and exercise.

Left untreated, gout can increase your risk of developing heart disease, type 2 diabetes, and chronic kidney disease.

Over the long term, losing weight may be an important step to treat gout, as being overweight increases your chances of developing gout. However, you should avoid extreme dieting, as losing weight too quickly can actually trigger gout attacks.

Avoiding high purine foods can help lower uric acid in your body, and consuming certain foods like vitamin C and coffee may help treat gout, according to some research.

Choi says that overall, the Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets seem to be beneficial for patients with gout. This means adding more whole grains, vegetables and fruits, and legumes to your diet and eating less meat. For more information about what to eat for each of these diets, check out our articles about the Mediterranean diet and the DASH diet.

Gout can be painful in the short term and can lead to serious illnesses in the long term, but there are treatments available to lower your risk. The best place to start is to talk to your doctor about diet and lifestyle changes you can make to improve your health.

More here:
What is gout? How to know if you have it and recommended treatment - Business Insider

Rheumatoid Arthritis and Lupus Treatments Market with Key Business Insights

Global Rheumatoid Arthritis and Lupus Treatments Market report is a comprehensive study of the market and the growth prospects in the market. The information offered in the report has been accumulated through both primary and secondary sources of data collection and also through interviews of industry experts. The study is an exhaustive database of authentic and relevant information that readers, researchers, analysts, and executive professionals for the purposes of academic or commercial research on the market can use to their benefit. The report includes essential market aspects like industry trends, segmentation, growth prospects, promising opportunities, prevalent growth trends, challenges, and competitive analysis.

Click Here to Access a PDF Copy of the Sample Rheumatoid Arthritis and Lupus Treatments [emailprotected] https://www.marketexpertz.com/sample-enquiry-form/53445

A conscious effort is made by the subject matter experts to analyze how some business owners succeed in maintaining a competitive edge while the others fail to do so makes the research interesting. A quick review of the realistic competitors makes the overall study a lot more interesting. Opportunities that are helping product owners size up their business further add value to the overall study.

Leading Players studied in this report are as follows:

AbbVieAmgenBayerBiogen IdecRocheJohnson and JohnsonMerckMitsubishi Tanabe PharmaNovartisPfizer

This research report has all the information you need to device optimum market strategies.

Production Analysis: The study includes a SWOT analysis of key market players in the Rheumatoid Arthritis and Lupus Treatments industry to assess their Strengths, Weaknesses, Opportunities, Threats, and examines the companys internal & external environments and the elements present that could affect the growth of the industry.

In market segmentation by types of Rheumatoid Arthritis and Lupus Treatments, the report covers-

Rheumatoid Arthritis TreatmentsLupus Treatments

The evaluation also includes the rates of production and consumption, gross revenue, and average product price and market shares of key players. The information gathered is further broken down by including regional markets, production plants, and product types available in the market. Other key points, like competitive analysis and trends, concentration rate, mergers & acquisitions, expansion tactics, which are vital to establishing a business in the sector, have also been included in the report.

In market segmentation by applications of the Rheumatoid Arthritis and Lupus Treatments, the report covers the following uses-

Hospitals and ClinicsAmbulatory Surgery CentersHomecare Settings

To get this report at incredible Discounts or for Report Customization, reach out to [emailprotected] https://www.marketexpertz.com/discount-enquiry-form/53445

Manufacturing Analysis:The report gives an extensive analysis of various segments of the market by studying the product range, applications, major regions, and leading companies in the industry. Additionally, the report also dedicates an individual section to give a detailed analysis of the manufacturing process, which includes information collected through both primary and secondary sources of data collection. The primary source of data collection contains interviews of industry experts who offer accurate insights into the future market scenario.

Sales and Revenue Estimation:By employing both top-down and bottom-up approaches to evaluate the past data relating to the sales and revenue, along with the current market scenario. Our team of analysts predicts the future growth of the market and the development of the market in the leading geographies. The study also includes a comprehensive study of the product types, applications, end-users, leading regions, and critical participants in the industry. It also offers other critical data relating to the regulatory framework and guidelines, along with the macro-economic indicators influencing the growth of the market through detailed market estimation.

Rheumatoid Arthritis and Lupus Treatments Market Regional landscape includes: North AmericaAsia-PacificEuropeLatin AmericaMiddle East & Africa

Demand & Supply Assessment:The report also offers key highlights relating to the manufacturing processes, along with a cost analysis, rates of consumption and production, import/export status, product range, and supply chain assessment.

Competitive landscape:The report sheds light on critical information relating to the company profiles, product portfolio, growth prospects, cost assessment, total sales, revenue generated, market shares held by key regions, established companies, and emerging players.

To buy this report, [emailprotected] https://www.marketexpertz.com/checkout-form/53445

The Rheumatoid Arthritis and Lupus Treatments market report provides accurate market insights into the inclination in consumer preferences and behavior, along with an overview of the market data and major companies. The study offers all relevant information to help readers optimize on the market opportunities and formulate lucrative business strategies.

The Rheumatoid Arthritis and Lupus Treatments Market Research/Analysis Report addresses the following questions:

Request for Free Sample Report To Understand the structure of the complete [emailprotected] https://www.marketexpertz.com/sample-enquiry-form/53445

In conclusion, the Rheumatoid Arthritis and Lupus Treatments Market report is a reliable source for accessing the Market data that will exponentially accelerate your business. The report provides the principal locale, economic scenarios with the item value, benefit, supply, limit, generation, request, Market development rate, and figure and so on. Besides, the report presents a new task SWOT analysis, speculation attainability investigation, and venture return investigation.

Original post:
Rheumatoid Arthritis and Lupus Treatments Market Share, Trends and Leading Players By 2026 - News Times