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Archive for the ‘Arthritis’ Category

Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage – DocWire News

Tuesday, May 19th, 2020

OBJECTIVE:

Periarticular osteophyte formation is observed during the repair of damaged joints in rheumatoid arthritis (RA); however, little is known about its clinical and functional roles. This study aimed to determine the influence of periarticular osteophyte formation on the incidence oftotal knee arthroplasty(TKA) (a surrogate for long-term outcomes of joint destruction) in patients with RA.

This retrospective longitudinal study included atotalof 130 symptomatic (tender and/or swollen)kneejoints in 80 patients starting biologics. Cumulative incidences of TKA were compared according to the presence or absence of osteophyte on plain anteroposterior radiograph (osteophyte ()) and the extent of advanced joint damage as defined by Larsens grading system (0-II vs. III-V).

Kaplan-Meier estimates showed a significantly lower cumulative incidence of TKA for the osteophyte (+) group (n=33) compared with the osteophyte (-) group (n=31) in the Larsen grades III-V group (38 vs. 74% at 10years, P=0.010), whereas no significant difference was observed between the osteophyte (+) (n=11) and osteophyte (-) (n=55) groups in the Larsen grades 0-II group (9 vs. 10% at 10years). Multivariate Cox proportional hazards analysis revealed that older age (hazard ratio (HR), 1.04 per 1year; 95% confidence interval (CI), 1.01-1.08) and osteophyte formation (HR, 0.39; 95% CI, 0.19-0.79) independently predicted TKA in the Larsen grades III-V group, whereas none of the assessed variables predicted TKA in the Larsen grades 0-II group.

Osteophyte formation reduces the incidence of TKA in patients with RA who have advanced joint damage.Key Points Older age and Larsen grade were independent predictors oftotal knee arthroplasty(TKA) in rheumatoid arthritis (RA) patients. Periarticular osteophyte formation reduced the incidence of TKA in RA patients with Larsen grades III-V.

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Periarticular osteophyte formation protects against total knee arthroplasty in rheumatoid arthritis patients with advanced joint damage - DocWire News

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Arthritis treatment: Follow this healthy diet to ease joint pain and stiffness – Express

Tuesday, May 19th, 2020

Arthritis comes in many forms but the most common in the UK is osteoarthritis, which affects nearly nine million people. Osteoarthritis initially affects the smooth cartilage lining of the joint. This makes movement more difficult than usual, leading to pain and stiffness.

There is currently no cure for osteoarthritis but one particular lifestyle intervention has been shown to alleviate pain and stiffness in two of the most commonly affected joints - the knees and hips.

According to a study published in the Journal of Nutrition, Health and Aging, a Mediterranean diet can reduce markers of inflammation and improve knee flexion and hip rotation in people with osteoarthritis.

The knee flexion is the measurable degree in which your leg (and knee joint) can bend.

The study, commissioned by UK charity Arthritis Action, examined the effects of a Mediterranean type diet on 99 patients with osteoarthritis.

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Dr Lex Mauger, co-author of the study and Director for BSc Sports Science at the University of Kent, said:

The Mediterranean diet has previously been associated with a number of health benefits, but the exciting finding with this study is that specific guidance on adhering to this type of diet can change eating behaviour and result in a number of beneficial physiological changes, relevant to osteoarthritis, in a relatively short period of time.

As osteoarthritis is a chronic disease, treatment is primarily about managing the symptoms, and this study shows that eating healthily may help form part of that treatment strategy. Benefits from the intervention in this study were evident after only four months, so it is possible that an even greater benefit could be seen in people who make longer-term improvements to their normal diet.

The Arthritis Foundation explained: "The disease-fighting power of the Mediterranean diet stems from its ability to regulate inflammation by focusing on anti-inflammatory foods (berries, fish, olive oil) and excluding or limiting pro-inflammatory ones (red meat, sugar and most dairy).

As Michelle Babb, MS, RD, a Seattle-based nutrition educator, explained, OA is now known to have an inflammatory component, so this way of eating can lead to real improvements in joint pain.

There are a variety of foods in the Mediterranean diet that are high in fibre, beta carotene, magnesium and omega 3s, which have been found to actively reduce inflammatory markers in human studies," she said.

Babb added: "Ive had [arthritis] patients who have been able to discontinue the use of non-steroidal anti-inflammatory drugs (NSAIDs) because of transitioning to a Mediterranean diet. Some even report a noticeable difference in pain in the first week."

An indirect benefit of following a healthy, balanced diet such as the Mediterranean diet is that it can help to aid weight loss.

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Arthritis and related conditions: The biggest causes of pain in the UK – Open Access Government

Tuesday, May 19th, 2020

Millions of people in the UK live in pain every day. Arthritis and related conditions are the biggest causes of that pain.

In fact, more than half of the 10 million people with arthritis say they experience pain every single day, and eight out of ten say they experience it most days. (1) Its not short-term or one-off bursts but persistent pain. It can fluctuate but for most but it never truly goes away.

During the COVID-19 pandemic, many people with arthritis will be unable to access essential services to manage their pain such as physiotherapy or hydrotherapy. The impact of joint replacement operations cancelled or postponed will mean more people with arthritis living in debilitating pain. Versus Arthritis is supporting people with arthritis during these challenging times by standing with them and working for them so they are not alone.

The persistent pain of arthritis makes the simplest of movements exhausting and excruciating. Imagine not being able to stand, walk, hug or hold without pain. Imagine not being able to work. To be independent. Imagine not being able to remember what its like to not be in pain.

The pain itself and the fear of making it worse can lead to isolation and depression. In fact, depression is four times more common among people in persistent pain compared to those without pain. (2)

Put simply, pain erodes life.

Ken Brown is 61 and has been living with the pain of osteoarthritis for most of his adult life. He says: My experience of the pain from arthritis is the feeling you get the day after a very intense workout at the gym. The fatigue is so hard to describe, but the worst feeling of all is the grinding bone pain as if someone has drained the energy out of you. The realisation that you cant do what you used to is hard to come to terms with its difficult to even go out to the shops sometimes.

Pain is not something that people can see and is therefore often difficult for others to comprehend. It is a hidden disability.

But it has more than just a personal impact. The impact of musculoskeletal pain on our health service is huge. It is estimated that arthritis-related pain alone costs the health service 5 billion every year in England (3) and accounts for one in eight of all GP appointments. (4)

Our society today creates an environment where people in pain are too often dismissed or not taken seriously. Everyday phrases like no pain, no gain, the glorification of your pain threshold or ability to grin and bear it, create a culture that exacerbates silently suffering with pain. It prevents people from speaking openly and honestly about how they are feeling, something which is an integral part of effective pain management for millions of people.

Theres also been insufficient progress on treatment. The options patients are offered today havent moved on significantly in a few decades. For many, they are limited to drugs rather than a care plan that includes effective treatments like physiotherapy, exercise and talking therapies.

At Versus Arthritis, we believe its time for change. The pain associated with arthritis should not be tolerated in society, and people with the condition should not have to live silently with its impact.

Research into pain is underfunded in the UK and over the past five years, we have begun to invest significantly to redress this and help us understand the complex causes and treatments for the pain of arthritis.

Along with the direct funding we provide ourselves, we have been working in partnership with other funders to influence their research spend and to convince them to invest in pain research. We are leading a co-ordinated national approach to pain research that aims to accelerate our understanding of persistent pain, while developing and testing new ideas, solutions and treatments that can be developed and scaled for the greatest possible impact on people living with persistent pain.

For the first time, we brought together international health and research experts and people with arthritis, to identify and set out the challenges that must be tackled across research and public health to improve the quality of life for people living with persistent pain.

In response to this initiative, we have launched a joint partnership with the UK Government through UK Research and Innovation (UKRI) to establish the Advanced Pain Discovery Platform (APDP). The APDP is an ambitious 24 million five-year partnership that aims to unravel the complexities of persistent pain by bringing together multidisciplinary experts in the UK along with people living with persistent pain to tackle the problem. Through cutting edge science and technology, the platform will focus on human data, bridging biological, psychological and social sciences to better understand pain mechanisms and develop new treatment solutions. Through our industry partners, we will ensure a rapid take up and development of new treatments.

With the new knowledge developed by the partnership, we will also better understand the transition from acute to persistent chronic pain and also how persistent chronic pain may itself worsen and become debilitating. Understanding biological mechanisms will help inform future approaches to both primary and secondary prevention of persistent pain.

The IASP 2020 Global Year for the Prevention of Pain is an important initiative that shines a light not only on the impact of persistent pain, but also highlights what is known about primary and secondary prevention of persistent pain. There is much that can be done to reduce the chance of developing persistent pain and through the global year initiative, IASP aims to disseminate important information to lead to better outcomes for patients.

References

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When rheumatoid arthritis is mentioned, should only dryness come to mind? – Physician’s Weekly

Tuesday, May 19th, 2020

To evaluate corneal parameters of rheumatoid arthritis (RA) patients by corneal topography.One hundred two RA patients and 60 control subjects were enrolled. Corneal topography measurements and ophthalmologic findings were examined from all participants files.Corneal thickness measurements were significantly lower in the RA group (p=0.025). All values of corneal curvatures (K1, K2, Kmean) in 3mm, 5mm, and 7mm zones were found statistically significantly higher in the RA group compared with the control group. Forty-five RA patients had a dry eye. Disease duration was correlated with dry eye in the RA group. There was a significant correlation between the duration of disease in RA patients and mean corneal curvatures (p 0.012/0.010/0.007, 3/5/7mm respectively) and central corneal thickness (p 0.025). There is no statistical difference between other topographic measurements.The results suggest that RA patients have thinner and steeper corneas compared with control subjects. These parameters change in negative correlation as the duration of the disease increases.Key Points Rheumatoid arthritis is an autoimmune disease with systemic involvement. In rheumatoid arthritis, systemic involvement is affected in the eyes. When it comes to eye involvement, it comes to mind that it makes the eyes more dryness. In addition to dryness in the eyes, rheumatoid arthritis makes morphological changes in the cornea.

PubMed

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Rheumatoid Arthritis Increases Risk for Early Cardiac Events in End-Stage Renal Disease – Rheumatology Advisor

Tuesday, May 19th, 2020

Clinicians should be aware that patients with rheumatoid arthritis (RA) who develop end-stage renal disease (ESRD) are at risk of experiencing cardiac events sooner than patients in the general population, although RA is not an independent risk factor for all-cause or cardiovascular mortality in ESRD. This is according to findings published in the Journal of Clinical Rheumatology.

Using Cox proportional hazards modeling, this cohort study was designed to characterize cardiovascular disease (CVD) events, cardiovascular mortality, and all-cause mortality in patients with RA and ESRD compared with those with ESRD without RA. Data from 48,005 patients were obtained from the United States Renal Database System (USRDS). The study sample included 407 patients with ESRD and RA and a random sample of 5% (n=2417) of patients with ESRD without RA. The study duration spanned up to 5 years, depending on initiation of dialysis and mortality.

Heart failure was the most common CVD event among participants both with and without RA (47.4% and 27.8%, respectively). Compared with those without RA, patients with RA showed a significantly shorter mean time from start of dialysis to an incident CVD event (20.112.2 months vs 21.214.1 months; P <.01). No significant differences in total incident CVD events were seen by RA status (P =.09) or individual CVD events (P .11) besides atherosclerosis and heart failure, which were significantly more prevalent in participants without RA (P <.01 for both). Multivariable adjusted models showed that RA was not associated with increased 5-year risk for all-cause mortality (adjusted hazard ratio [aHR], 1.09; 95% CI, 0.94-1.27) or cardiovascular mortality (aHR, 0.95; 95% CI, 0.74-1.22). In patients with RA, risk factors for all-cause and cardiovascular mortality included older age and a higher Charlson comorbidity index.

Study investigators concluded that time to first cardiac event is shorter in patients with RA and ESRD compared with the general population of patients with ESRD. However, in patients with ESRD, RA is not an independent risk factor for either all-cause or cardiovascular mortality.

Reference

Paudyal S, Waller JL, Oliver A, et al. Rheumatoid arthritis and mortality in end stage renal disease. J Clin Rheumatol. 2020;26(2):48-53.

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COVID 19 PANDEMIC: Rheumatoid Arthritis Diagnosis Tests Market Report (2019-2025) | The demand for the Market will drastically increase in the Future…

Tuesday, May 19th, 2020

The Rheumatoid Arthritis Diagnosis Tests report provides independent information about the Rheumatoid Arthritis Diagnosis Tests industry supported by extensive research on factors such as industry segments size & trends, inhibitors, dynamics, drivers, opportunities & challenges, environment & policy, cost overview, porters five force analysis, and key companies profiles including business overview and recent development.

Rheumatoid Arthritis Diagnosis Tests MarketLatest Research Report 2020:

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In this report, our team offers a thorough investigation of Rheumatoid Arthritis Diagnosis Tests Market, SWOT examination of the most prominent players right now. Alongside an industrial chain, market measurements regarding revenue, sales, value, capacity, regional market examination, section insightful information, and market forecast are offered in the full investigation, and so forth.

Scope of Rheumatoid Arthritis Diagnosis Tests Market: Products in the Rheumatoid Arthritis Diagnosis Tests classification furnish clients with assets to get ready for tests, tests, and evaluations.

Major Company Profiles Covered in This Report

Antibodies Inc.,Euro Diagnostica AB,Qiagen NV,Siemens Healthcare GmbH,Bio Rad Laboratories Inc.,Genway Biotech, Inc., Abbott Diagnostics,Beckman Coulter, Inc.,F. Hoffmann-La Roche Ltd.,Thermo Fisher Scientific Inc,others.

Rheumatoid Arthritis Diagnosis Tests Market Report Covers the Following Segments:

Application: By Type:,Serology Tests ,o Erythrocyte Sedimentation rate ,o Anti-Cyclic Citrullinated Peptide ,o Rheumatoid Factor ,o Antinuclear Antibody,o Uric Acid,o Others,Monitoring Rheumatoid Arthritis Treatment Efficiency Tests ,o Muscle Enzyme Tests ,o Salicylate Level Count,o Creatinine Test,By End-User:,Hospitals,Diagnostics Laboratories,Ambulatory Surgical Centers

North America

Europe

Asia-Pacific

South America

Center East and Africa

United States, Canada and Mexico

Germany, France, UK, Russia and Italy

China, Japan, Korea, India and Southeast Asia

Brazil, Argentina, Colombia

Saudi Arabia, UAE, Egypt, Nigeria and South Africa

Market Overview:The report begins with this section where product overview and highlights of product and application segments of the global Rheumatoid Arthritis Diagnosis Tests Market are provided. Highlights of the segmentation study include price, revenue, sales, sales growth rate, and market share by product.

Competition by Company:Here, the competition in the Worldwide Rheumatoid Arthritis Diagnosis Tests Market is analyzed, By price, revenue, sales, and market share by company, market rate, competitive situations Landscape, and latest trends, merger, expansion, acquisition, and market shares of top companies.

Company Profiles and Sales Data:As the name suggests, this section gives the sales data of key players of the global Rheumatoid Arthritis Diagnosis Tests Market as well as some useful information on their business. It talks about the gross margin, price, revenue, products, and their specifications, type, applications, competitors, manufacturing base, and the main business of key players operating in the global Rheumatoid Arthritis Diagnosis Tests Market.

Market Status and Outlook by Region:In this section, the report discusses about gross margin, sales, revenue, production, market share, CAGR, and market size by region. Here, the global Rheumatoid Arthritis Diagnosis Tests Market is deeply analyzed on the basis of regions and countries such as North America, Europe, China, India, Japan, and the MEA.

Application or End User:This section of the research study shows how different end-user/application segments contribute to the global Rheumatoid Arthritis Diagnosis Tests Market.

Market Forecast:Here, the report offers a complete forecast of the global Rheumatoid Arthritis Diagnosis Tests Market by product, application, and region. It also offers global sales and revenue forecast for all years of the forecast period.

Research Findings and Conclusion:This is one of the last sections of the report where the findings of the analysts and the conclusion of the research study are provided.

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Spontaneous Rupture of Extensor Pollicis Longus Tendon: Clinical and Occupational Implications, Treatment Approaches and Prognostic Outcome in…

Tuesday, May 19th, 2020

Background:Spontaneous rupture of extensor pollicis longus (EPL) tendon is a rare condition often found in patients actively having regular extensive use of hands and fingers especially the thumb. In this article, we report 7 cases of spontaneous rupture of EPL tendon and investigate the associated factors and treatment outcome.

Methods:Retrospectively, the databases for the 7 cases were retrieved and studied. These cases represent all cases of spontaneous rupture of EPL in our institution. Demographic data, clinical presentation, any history of trauma or steroid injection, laboratory and clinical findings suggestive for rheumatoid arthritis, co-morbidities and imaging findings were obtained. In addition, the operative technique and findings were retrieved. Moreover, histopathological studies and follow-up assessment were included.

Results:Six males and one female were included. The mean age was 45.2 years. No prior history of trauma, rheumatological disease or steroid use was detected in any patient. All patients experienced prodromal pain in the radial side. Clinical examination was the most effective diagnostic measure. Magnetic resonance imaging (MRI) was used to confirm the diagnosis and to look for other abnormalities that may predispose to rupture. Five patients underwent extensor indicis proprius to EPL tendon transfer employing Pulvertaft weave technique and one patient underwent primary repair as there was a little gap in the tendon ends. In this study, one patient refused any treatment. All patients achieved a favorable outcome at the last follow-up.

Conclusion:Diagnosis of spontaneous ruptures of EPL tendon can be confirmed through clinical examination and MRI for patients with restricted thumb movement even with the absence of any identifiable predisposing risk factor. During surgery, detailed attention must be drawn towards the tendon ends which can have unusual gaps and bone abnormalities.

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Innovating in inflammation and immunology – – pharmaphorum

Tuesday, May 19th, 2020

For World Inflammatory Bowel Disease day we spoke to Pfizers Matt Shaulis, president of international developed markets for inflammation and immunology, to hear how the company hopes to harness innovation to address the many unmet needs in these disease areas.

What would you say are the biggest challenges in the area at the moment?

One of the biggest challenges in the area of immune-mediated and inflammatory diseases is the lack of understanding of the true burden of these diseases, which has meant that these patients have historically been underserved.

While significant advances have been made in the treatment of rheumatic diseases, such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), many patients still experience the daily burdens of living with these diseases.

Whether a patient is unable to reach remission with his or her current treatment or is settling for good enough, uncontrolled disease can lead to irreversible joint damage and may also impact overall wellbeing and daily functioning.

For this reason, different treatment options in addition to timely diagnosis and access to advanced therapies are needed.

As for gastroenterology, chronic inflammatory diseases of the digestive tract can be painful, inconvenient and embarrassing, dramatically affecting how patients live their lives. Many patients have not been able to achieve optimal symptom control with current therapies and lead a life profoundly impacted by ongoing symptoms.

Wearable technologies commonly seen in the fitness field can be employed to measure itching and sleep disturbance in atopic dermatitis

There is also a critical unmet need for diseases such as nonalcoholic steatohepatitis (NASH), a leading cause of liver transplant, for which there are no approved drug therapies.

In dermatology, despite significant recent advances in inflammatory skin diseases, there are still many such as atopic dermatitis (AD), alopecia areata (AA) and vitiligo where new treatments are needed to make a meaningful impact in patients lives.

Are there any particular issues in diagnosis and detection youre hoping to address?

The treatment landscape for immune-mediated diseases has evolved significantly, from broad immunosuppression with steroids to targeted immune modulation through selective agents. However, improved treatment options will only really make a difference to patients lives if they go hand in hand with an increase in awareness among physicians and other healthcare providers.

We need to work with the medical community to enable a deeper understanding of immunological disease management, triggers, and the importance of treatment adherence. The resulting improvement in patient wellbeing can soften the impact on healthcare systems.

What does innovation mean to you when it comes to inflammation and immunology?

Innovation comes in many forms for the inflammation and immunology (I&I) team. Innovation in research and development is crucial and we are relentlessly pursuing new breakthroughs such as next generation kinase inhibitors, novel biologics, biosimilars and topicals.

But we also strive to innovate in how we run clinical trials both in terms of the technology we use for example employing wearable technologies commonly seen in the fitness field to measure itching and sleep disturbance through to the means to undertake testing in patients homes to obtain true real world evidence.

Finally, we partner with a variety of organisations who are driving innovation in helping patients make informed lifestyle choices, manage treatment adherence and facilitate doctor/patient relationships.

What kind of beyond-the-pill measures are important for patients in these disease areas?

There are improvements that could be proposed at all levels of the healthcare ecosystem to help address immunological and inflammatory diseases, but a critical step is for stakeholders to collaborate and drive meaningful change at the policy level.

This begins with establishing guidelines to ensure standardised treatment paradigms. Further assistance can be provided to patients through holistic patient and family support programmes that integrate disease management with good overall health and wellness practices.

One organisation we are partnering with in this regard is Sidekick Health, which offers technology-based solutions for patients suffering from the two main IBD conditions ulcerative colitis (UC) and Crohns disease (CD), and also for patients with rheumatoid arthritis (RA), atopic dermatitis (AD) and psoriatic arthritis (PsA).

The platform provides these patients with a rich user experience, where they earn rewards for managing their nutrition, exercise, sleep, stress and medication adherence. They also receive condition-specific education, and a connection to a community of health professionals and patients on a similar health journey.

Finally, expanded general awareness of AD can break the stigma associated with its flare-ups. When patients concerns are met with understanding and support, it can lessen their embarrassment and anxiety. This in turn may make them more likely to seek the help they need to manage their condition successfully.

Whats your overall view on how digital technology fits into I&I research, treatment and care?

There is a lot of interesting work being done in I&I research utilising technologies from the broader health arena. For example, our own Pfizer Innovation Research (PfIRe) lab is looking at solutions such as using wearable devices to help scientists monitor treatment for atopic dermatitis.

The lab equips patients with a device that can monitor sleep disruption caused by scratching. The team assesses that sleep disruption both with treatment and without treatment to determine how effective a particular therapy is for that particular endpoint. This is particularly critical in assessing scratching and sleep disruption in younger patients who would have trouble recalling or indeed articulating these symptoms themselves.

Do you think eczema and other inflammatory skin diseases are overlooked compared to other conditions?

Chronic inflammatory skin diseases can have a devastating impact on a persons mental and emotional wellbeing, although they are often overlooked as being simply cosmetic. This leads to a vast discrepancy in how patients are managed around the globe. Furthermore, the physical and social pressure that this disease creates goes hand in hand with a financial burden as patients pay for various products and treatments in search of symptom relief.

One recent study found that the average AD patient spends an additional 927 per year on health care expenses. Add to this the potential cost of doctors visits and treatments for co-morbidities, and the economic impact of absenteeism and time off work, and we start to get a true picture of the cost this condition imposes on health care systems at large.

We are now seeing an increased focus on developing treatments for chronic inflammatory skin diseases, but there is still a long way to go.

How do you see I&I evolving in the future?

The JAK pathways are believed to play an important role in inflammatory processes as they are involved in signalling for over 50 cytokines and growth factors, many of which drive immune-mediated diseases. JAK inhibition may offer patients with these conditions a potential new advanced treatment option.

Were taking a different R&D approach to that of other companies involved in JAK research instead of studying a single molecule for all its potential uses, where it may not be optimal for some, we purposefully match Pfizers candidates with unique selectivity profiles to the conditions where, if approved, we believe they have the greatest potential to address unmet need.

Ultimately, we are working toward supporting fast, accurate diagnoses, providing effective treatment options and enabling appropriate patient choices which lead to freedom from the burden of immune-mediated and inflammatory diseases.

About the interviewee

Matt Shaulis currently serves as the president of Pfizer inflammation and immunology for international developed markets. He has approximately 20 years of experience in the pharmaceutical industry across several functions including: in-line and global strategic marketing, sales management, strategic customers group, licensing and acquisitions, finance, and compound and indication launches across multiple disease states. He joined Pfizer from Teva Pharmaceuticals, where he was vice president, global CNS, multiple sclerosis.

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Back Pain and Types of Arthritis – Newswire

Tuesday, May 19th, 2020

Dr.Brian McKay of Core Health Darien discusses arthritis pain and how it relates to low back pain. Core Health Darien is located at 551 Post Road.

(Newswire.net -- May 14, 2020) Darien, CT --Osteoarthritis is a common condition involving articular surfaces that can develop gradually over time into a debilitating condition, which causes pain and restriction of motion. Specifically, spine osteoarthritis is the presence of disc degeneration and osteophyte formation as well as pain. Facet joint arthritis is present in 19% of individuals between the ages of 45 and 65 years of age and 57% of patients over the age of 65 in the United States. The facet joint is where the bones meet to form a biomechanical arch, this is where weight is supported. With undue stress, the surface of the bone starts to wear out causing pain. Arthritis can affect any articular surface; it is more likely to affect weight-bearing joints, which includes the spinal column.

Osteoarthritis is a chronic, degenerative disease. Low back pain and spine arthritis are among the leading health-related causes of disability and reduction in patients' quality of life. Pathologically osteoarthritis can cause spinal stenosis, herniated nucleus pulposus, myelopathy, radiculopathy, spondyloarthritis, and spondylolisthesis. Also complicating the diagnosis is how radiographic imaging of spine osteoarthritis does not necessarily correlate with patients' pain and thus leads to treatment options that may not improve symptoms.

Osteoarthritis is responsible for the breakdown of the cartilage (the tissue that cushions the ends of the bones between joints), bony changes of the joints, deterioration of tendons and ligaments, and various degrees of inflammation of the joint lining (called the synovium). Spinal arthritis is a degenerative process that develops over time in response to the stresses placed on the spinal joints.

Arthritis is a general term that describes conditions that affect your joints. There are many types of arthritis besides osteoarthritis, here are a few of the more common ones. Ankylosing spondylitis (AS) is a type of inflammatory arthritis that targets the joints of the spine. Reactive arthritis is a form of arthritis that occurs as a result of some bacterial infections. Rheumatoid arthritis is a long-term condition that causes pain, swelling, and stiffness in the joints. Because it can affect multiple other organs of the body, rheumatoid arthritis is referred to as a systemic illness and is sometimes called rheumatoid disease. Psoriatic arthritis is a chronic, inflammatory disease of the joints and the places where tendons and ligaments connect to bone. Psoriatic arthritis can also cause inflammation of the eyes, such as Conjunctivitis and Iritis.

Osteoarthritis is the most common type of arthritis. The treatment for these common types of arthritis is usually rest, ice, and NSAIDs. Lumbar osteoarthritis is a form of degenerative arthritis in the lower back that causes pain, stiffness, and inflammation in the joints between vertebrae. Arthritis is the most common cause of lower back pain, especially in people over age 50, and affecting approximately 27 million Americans. While osteoarthritis can damage any joint, the disease most often affects joints in your spine, hands, knees, and hips.

Chiropractic care can help take the stress off the arthritic joints by restoring biomechanical efficiency. When the joints are properly aligned the muscles, ligaments, tendons, and discs all work together to support the body's weight effortlessly. You should consider chiropractic care if you have arthritis. Chiropractic treatment is natural and unlike NSAIDS has no dangerous side effects.

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Treat-to-target With Urate Lowering Therapy Recommended for All Gout Patients – Rheumatology Network

Tuesday, May 19th, 2020

New treatment guidelines for gout strongly support a treat-to-target strategy for urate lowing therapy with a serum urate target of less than 6 mg/dl.

The 2020 iteration of the guidelines by the American College of Rheumatology (ACR) are based on a review of data from recently published research clinical trials. There are 42 recommendations of which 16 are considered strong due to the high quality of the evidence. The strong recommendations address indications, initiation of treatment, titration and treat-to-target, treatment approaches post urate lowering therapy (ULT) failure, and treatment protocols for managing flares.

With this update, we sought to look at new and emerging clinical evidence that would be beneficial for treating patients with gout , said John FitzGerald, M.D., Ph.D., a rheumatologist and one of the guidelines co-principal investigators. The guideline now includes expanded indications for starting ULT, a greater emphasis to use allopurinol as the first line agent for all patients with gout that require urate lowering therapy including those patients with chronic kidney disease, and broadened recommendations about who needs HLA-B*5801 testing prior to starting allopurinol.

The 2020 and 2012 versions both support the use of treat-to-target strategies for urate-lowering therapy (ULT). In 2012, the recommendation was made conditionally due to poor quality evidence, but in 2020, it was bumped up to a strong recommendation due to higher quality evidence.

"Data from more recent research clinical trials comparing treat-to-target protocols versus usual care provide the basis for the strong recommendation to use a treat-to-target strategy with urate lowering therapy that includes a plan to achieve and maintain an serum urate target of less than 6 mg/dl to optimize patient outcomes," wrote the authors of the guidelines published this month in the journal Arthritis Care and Research. "These guidelines reinforce the strategy of starting with low-dose ULT and titrating up to achieve the serum urate (SU) target."

RELATED: "The 2020 Treatment Guidelines for Gout"

Adherence to urate lowering therapies is poor in the U.S. and over the last 20 years, there has been no increase in the use of urate lowering therapies among gout patients. The authors speculated this may be due to conditional recommendations made in 2012, but adherence to ULT in gout is lowest among seven common chronic medical conditions so there may be factors at play.

Among the most noteworthy recommendation, allopurinol is recommended as the first-line treatment for all patients, including patients with chronic kidney disease. This recommendation was made, in part, due to the cost of medications and concerns over cardiovascular-related issues with febuxostat.

For patients with severe disease, the guideline does not support achieving serum urate levels of below 6 mg/dl. "There is ample evidence that lower serum urate levels hasten the resolution of tophi and are associated with less frequent gout flares, suggesting that lower serum urate thresholds may be preferable for patients with more burdensome gout."

The authors note that while there have been extensive clinical trials on treatment strategies for achieving a serum urate target of less than 6 mg/dl, to date, there are no data to support targeting lower serum urate levels for patients with severe disease.

While it wasn't included in the 2012 guidelines, the indications for receiving urate lowering therapies have been expanded to include individuals with evidence of radiographic damage due to gout. This is important because gout presents in a number ways, including joint damage.

REFERFENCE: "2020 American College of Rheumatology Guideline for the Management of Gout," Arthritis Care and Research, May 6, 2020. DOI:10.1002/art.41247

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Treat-to-target With Urate Lowering Therapy Recommended for All Gout Patients - Rheumatology Network

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Global Rheumatoid Arthritis Therapeutics Market SHARE, SIZE 2020| EMERGING RAPIDLY WITH LATEST TRENDS, GROWTH, REVENUE, DEMAND AND FORECAST TO 2026 -…

Tuesday, May 19th, 2020

Global Rheumatoid Arthritis Therapeutics Market Size, Status and Forecast 2020-2026 initially represents the historical overview of the current market situation and forecast 2026. The report gives a comprehensive study of various factors of the global Rheumatoid Arthritis Therapeutics market. The report analyzes the market by carrying out the valuation in the constrained period. After an in-depth market study and analysis of the market, the analysts have testified the constant growth in the market, considering the current unsteady market scenario in terms of revenue. The major players dominating the market are focused upon throughout the by analyzing their revenue, their business summary, product segmentation along with the latest developments.

Then the report gives analysis on market size, trends, share, growth, and cost structure and drivers. The global Rheumatoid Arthritis Therapeutics market report has studied key opportunities in the market and influencing factor which is useful and helpful to the business. The report assists users to analyze the future demand and predict exact implementation. The report explains current business and industrial developments, future policy changes, and opportunities available in the market. It gives a detailed summary of the market trends, shares, and patterns of revenue growth and the market value.

DOWNLOAD FREE SAMPLE REPORT: https://www.magnifierresearch.com/report-detail/30461/request-sample

Competitive Analysis:

The report gives you a detailed list of competitive analysis and it would give you a detailed report on the various market strategies, models and growth patterns in terms of revenue of the competitors. The players examination will help the reader identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and production by manufacturers during the forecast period of 2015 to 2026. Major market players of the global Rheumatoid Arthritis Therapeutics market are analyzed on various aspects such as company profile, product portfolio, sales analysis, revenue generation through the forecast period from 2020 to 2026.

Leading companies reviewed in the report are: AbbVie, Boehringer Ingelheim, Novartis, Regeneron Pharmaceuticals, Pfizer, Bristol-Myers Squibb, F. Hoffmann-La Roche, UCB S.A., Johnson & Johnson Services, Amgen,

Market product type segmentation as provided below:

Market applications can be fragmented as: Prescription, Over-the-Counter (OTC),

The global Rheumatoid Arthritis Therapeutics market is analyzed across key geographies namely: North America (United States, Canada, Mexico), Asia-Pacific (China, Japan, South Korea, India, Australia, Indonesia, Thailand, Malaysia, Philippines, Vietnam), Europe (Germany, France, UK, Italy, Russia, Rest of Europe), Central & South America (Brazil, Rest of South America), Middle East & Africa (GCC Countries, Turkey, Egypt, South Africa, Rest of Middle East & Africa)

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The newly arrived players in the global Rheumatoid Arthritis Therapeutics market can up their growth potential by a great amount and also the current dominators of the market can keep up their dominance for a longer time by the use of our report. The report will cover the main region and share information about the market size and value in a particular region. It also offers similar information for other regional segmentation. With the help of this research knowledge about the market and its key players can be gained for those wanting to enter the market.

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Can hydroxychloroquine prevent a COVID-19 infection? Thats Trumps hope, it appears and it is being looked into by researchers – MarketWatch

Tuesday, May 19th, 2020

President Donald Trumps unprompted admission that hes been taking hydroxychloroquine for a week and a half is aligned to some degree with medical research that aims to understand if the controversial drug can prevent infections with the coronavirus in high-risk frontline workers.

Hydroxychloroquine, which is approved by the Food and Drug Administration to treat malaria, lupus and rheumatoid arthritis, is not a proven treatment or prophylaxis for COVID-19. It received emergency-use authorization from the FDA in mid-March to be used in certain clinical settings as a treatment for COVID-19 patients. But, in the two months since then, medical experts have raised questions about the heart risks associated with the drug and its efficacy against the virus and how those concerns play out against a backdrop of political maneuvering.

Youd be surprised at how many people are taking it, especially the frontline workers before you catch it, Trump told reporters on Monday. I happen to be taking it.

Several White House staffers have recently tested positive for the coronavirus, including Katie Miller, Vice President Mike Pences press secretary, as well as one of Trumps personal valets. It is unclear whether Trump was exposed to any of those individuals; however, a letter from Dr. Sean Conley, the White House physician, that was shared on social media mentions that a member of Trumps support staff tested positive for COVID-19.

Read:The next stage of the COVID-19 recovery is here. This is how investors prepare, says UBS

Since the earliest days of the pandemic in the U.S., Trump has been promoting hydroxychloroquine and chloroquine, an older formulation of the same drug. His remarks in favor of the decades-old medicine likely helped spur a run on the drug that created a supply shortage for the patients who already take the treatment for lupus and rheumatoid arthritis.

But a series of medical studies, many of which haven't been peer reviewed, have concluded that the drug isnt efficacious against COVID-19 infections, including one conducted at Veterans Health Administration hospitals that found patients taking the drug had higher mortality rates. Then the FDA on April 24 issued a warning to health-care providers about the serious heart-rhythm problems that can occur in patients taking the drug. And Dr. Rick Bright, former director of Biomedical Advanced Research and Development Authority, has accused the administration in a whistleblower complaint of demoting him when he resisted promoting chloroquine without transparent information on the potential health risks.

Even the Federal Aviation Administration has warned pilots that they cant fly while taking the drugs or for 48 hours after the last dose, citing the known risks of these medications, such as cardiac rhythm disturbances and hypoglycemia against unproven benefits.

Among clinicians, however, it has been one of the few tools available to treat patients hospitalized with COVID-19, at least until Gilead Sciences Inc.s GILD, -3.23% remdesivir received an emergency-use authorization earlier this month. Many frontline clinicians are using a range of therapies, including zinc, azithromycin, hydroxychloroquine, and some HIV and anti-inflammatory arthritis drugs. Plus, hydroxychloroquine and chloroquine have proven safety profiles, are cheap to make and are readily available.

The choice to use these drugs has already been made, probably in hundreds of thousands of patients, but with scant evidence about the risks and benefits, researchers wrote in a New England Journal of Medicine editorial about hydroxychloroquine and chloroquine.

Raymond James analyst Steven Seedhouse, who said he still sees the potential in hydroxychloroquine, wrote in a May 7 note to investors that the study preprints, including the VA research, collectively paint a jumbled picture of hydroxychloroquine, and he believes the drug may reduce mortality by targeting antiviral activity that cant be picked up by a traditional diagnostic test.

See also:Darkest winter in modern history coming without stronger coronavirus response, Rick Bright to testify

This may be why clinical trials testing hydroxychloroquine as a possible COVID-19 treatment or prophylactic are moving forward.

The World Health Organization plans to study hydroxychloroquine and chloroquine in 20,000 frontline health-care workers, as will a trial funded by the COVID-19 Therapeutics Accelerator, which is backed by the Bill and Melinda Gates Foundation, among others.

The National Institute of Allergy and Infectious Diseases said last week it is testing hydroxychloroquine and the antibiotic azithromycin in 2,000 patients with mild and moderate cases of COVID-19 to see if the drug can reduce the need for hospitalizations and prevent death. The University of Minnesota began trialing hydroxychloroquine in health-care workers reporting pre- and post-exposure to the novel coronavirus in early April. A University of Chicago study aims to see if the drug can slow the progression of the disease and keep patients out of the hospital, and the Baylor Research Institute wants to see if hydroxychloroquine can prevent infections among health-care workers in high-risk settings.

From the existing data, which need validation in a trial, it looks like hydroxychloroquine could be a good agent for prophylaxis, Trevor Mundel, president of the Gates Foundations global health program, wrote on the accelerators website. It actually blocks the entry of the virus into the cell, so the hypothesis makes a lot of sense: if you have the drug in your system and you get exposed, you wont let the virus get into your cells and you wont get onset of disease.

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Can hydroxychloroquine prevent a COVID-19 infection? Thats Trumps hope, it appears and it is being looked into by researchers - MarketWatch

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Systemic Idiopathic Juvenile Arthritis Treatment Market 2020 | Growth Drivers, Challenges, Trends, Market Dynamics and Forecast to 2026 – Cole of Duty

Saturday, May 9th, 2020

Systemic Idiopathic Juvenile Arthritis Treatment Market has recently been added to its extensive repository by Market Research Intellect. This intelligence report includes research based on current scenarios, historical records and future forecasts. In this research report, specific data on various aspects such as type, size, application and end user were checked. It offers a 360-degree overview of the competitive landscape of industries. The SWOT analysis was used to understand the strengths, weaknesses, opportunities and threats faced by companies. This helps companies understand the threats and challenges ahead. The Systemic Idiopathic Juvenile Arthritis Treatment market is growing steadily and the CAGR is expected to improve over the forecast period.

The report includes the latest coverage of the impact of COVID-19 on the Systemic Idiopathic Juvenile Arthritis Treatment industry. The incidence has affected nearly every aspect of the business domain. This study evaluates the current scenario and predicts future outcomes of the pandemic on the global economy.

**Our FREE SAMPLE COPY of the report gives a brief introduction of the Systemic Idiopathic Juvenile Arthritis Treatment market, Detailed TOC, key players of the market, list of tables and figures and comprising key countries regions.**

We provide a detailed analysis of key players operating in the Systemic Idiopathic Juvenile Arthritis Treatment Market:

The scope of the Report:

The report analyzes the key opportunities, CAGR, and Y-o-Y growth rates to allow readers to understand all the qualitative and quantitative aspects of the Systemic Idiopathic Juvenile Arthritis Treatment market. A competition analysis is imperative in the Systemic Idiopathic Juvenile Arthritis Treatment market and the competition landscape serves this objective. A wide company overview, financials, recent developments, and long and short-term strategies adopted are par for the course. Various parameters have been taken into account while estimating market size. The revenue generated by the leading industry participants in the sales of Systemic Idiopathic Juvenile Arthritis Treatment across the world has been calculated through primary and secondary research. The Systemic Idiopathic Juvenile Arthritis Treatment Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Highlights of the Systemic Idiopathic Juvenile Arthritis Treatment market study:

Speculations for sales:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Systemic Idiopathic Juvenile Arthritis Treatment market. Additionally, it includes a share of every segment of the Systemic Idiopathic Juvenile Arthritis Treatment market, giving methodical information about types and applications of the market.

Key point summary of the Systemic Idiopathic Juvenile Arthritis Treatment market report:

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It presents an in-depth analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by creating a pin-point analysis of market segments and by having complete insights of the Systemic Idiopathic Juvenile Arthritis Treatment market.

This report helps users in comprehending the key product segments and their future.

Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Systemic Idiopathic Juvenile Arthritis Treatment market

Chapter 2: Evaluating the leading manufacturers of the global Systemic Idiopathic Juvenile Arthritis Treatment market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Systemic Idiopathic Juvenile Arthritis Treatment market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

Finally, the report global Systemic Idiopathic Juvenile Arthritis Treatment market describes Systemic Idiopathic Juvenile Arthritis Treatment industry expansion game plan, the Systemic Idiopathic Juvenile Arthritis Treatment industry knowledge supply, appendix, analysis findings and the conclusion. It includes a through explanation of the cutting-edging technologies and investments being made to upgrade the existing ones.

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Market Research Intellect also provides customization options to tailor the reports as per client requirements. This report can be personalized to cater to your research needs. Feel free to get in touch with our sales team, who will ensure that you get a report as per your needs.

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Tags: Systemic Idiopathic Juvenile Arthritis Treatment Market Size, Systemic Idiopathic Juvenile Arthritis Treatment Market Trends, Systemic Idiopathic Juvenile Arthritis Treatment Market Growth, Systemic Idiopathic Juvenile Arthritis Treatment Market Forecast, Systemic Idiopathic Juvenile Arthritis Treatment Market Analysis sarkari result, sarkari exam, sarkari naukri

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Gene therapy in mice builds muscle, reduces fat Washington University School of Medicine in St. Louis – Washington University School of Medicine in…

Saturday, May 9th, 2020

Visit the News Hub

Approach may lead to new treatment approach for osteoarthritis, obesity

Researchers at Washington University School of Medicine in St. Louis found that gene therapy in mice helped build strength and significant muscle mass quickly, while reducing the severity of osteoarthritis. The gene therapy also prevented obesity, even when the mice were fed a high-fat diet.

Exercise and physical therapy often are recommended to help people who have arthritis. Both can strengthen muscle a benefit that also can reduce joint pain. But building muscle mass and strength can take many months and be difficult in the face of joint pain from osteoarthritis, particularly for older people who are overweight. A new study in mice at Washington University School of Medicine in St. Louis, however, suggests gene therapy one day may help those patients.

The research shows that gene therapy helped build significant muscle mass quickly and reduced the severity of osteoarthritis in the mice, even though they didnt exercise more. The therapy also staved off obesity, even when the mice ate an extremely high-fat diet.

The study is published online May 8 in the journal Science Advances.

Obesity is the most common risk factor for osteoarthritis, said senior investigator Farshid Guilak, PhD, the Mildred B. Simon Research Professor of Orthopaedic Surgery and director of research at Shriners Hospitals for Children St. Louis. Being overweight can hinder a persons ability to exercise and benefit fully from physical therapy. Weve identified here a way to use gene therapy to build muscle quickly. It had a profound effect in the mice and kept their weight in check, suggesting a similar approach may be effective against arthritis, particularly in cases of morbid obesity.

With the papers first author, Ruhang Tang, PhD, a senior scientist in Guilaks laboratory, Guilak and his research team gave 8-week-old mice a single injection each of a virus carrying a gene called follistatin. The gene works to block the activity of a protein in muscle that keeps muscle growth in check. This enabled the mice to gain significant muscle mass without exercising more than usual.

Even without additional exercise, and while continuing to eat a high-fat diet, the muscle mass of these super mice more than doubled, and their strength nearly doubled, too. The mice also had less cartilage damage related to osteoarthritis, lower numbers of inflammatory cells and proteins in their joints, fewer metabolic problems, and healthier hearts and blood vessels than littermates that did not receive the gene therapy. The mice also were significantly less sensitive to pain.

One worry was that some of the muscle growth prompted by the gene therapy might turn out to be harmful. The heart, for example, is a muscle, and a condition called cardiac hypertrophy, in which the hearts walls thicken, is not a good thing. But in these mice, heart function actually improved, as did cardiovascular health in general.

Longer-term studies will be needed to determine the safety of this type of gene therapy. But, if safe, the strategy could be particularly beneficial for patients with conditions such as muscular dystrophy that make it difficult to build new muscle.

In the meantime, Guilak, who also co-directs the Washington University Center for Regenerative Medicine and is a professor of biomedical engineering and of developmental biology, said more traditional methods of muscle strengthening, such as lifting weights or physical therapy, remain the first line of treatment for patients with osteoarthritis.

Something like this could take years to develop, but were excited about its prospects for reducing joint damage related to osteoarthritis, as well as possibly being useful in extreme cases of obesity, he said.

Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F. Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity. Science Advances, published online May 8, 2020.

This work was supported by the Shriners Hospitals for Children, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute on Aging and the Office of the Director of the National Institutes of Health (NIH). Grant numbers AR50245, AR48852, AG15768, AR48182, AG 46927, AR073752, OD10707, AR060719, AR057235. Additional funding was provided by the Arthritis Foundation and the Nancy Taylor Foundation for Chronic Diseases.

Washington University School of Medicines 1,500 faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Childrens hospitals. The School of Medicine is a leader in medical research, teaching and patient care, ranking among the top 10 medical schools in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Childrens hospitals, the School of Medicine is linked to BJC HealthCare.

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Gene therapy in mice builds muscle, reduces fat Washington University School of Medicine in St. Louis - Washington University School of Medicine in...

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Rheumatoid Arthritis Drug Market 2020 | Growth Drivers, Challenges, Trends, Market Dynamics and Forecast to 2026 – Cole of Duty

Saturday, May 9th, 2020

Rheumatoid Arthritis Drug Market has recently been added to its extensive repository by Market Research Intellect. This intelligence report includes research based on current scenarios, historical records and future forecasts. In this research report, specific data on various aspects such as type, size, application and end user were checked. It offers a 360-degree overview of the competitive landscape of industries. The SWOT analysis was used to understand the strengths, weaknesses, opportunities and threats faced by companies. This helps companies understand the threats and challenges ahead. The Rheumatoid Arthritis Drug market is growing steadily and the CAGR is expected to improve over the forecast period.

The report includes the latest coverage of the impact of COVID-19 on the Rheumatoid Arthritis Drug industry. The incidence has affected nearly every aspect of the business domain. This study evaluates the current scenario and predicts future outcomes of the pandemic on the global economy.

**Our FREE SAMPLE COPY of the report gives a brief introduction of the Rheumatoid Arthritis Drug market, Detailed TOC, key players of the market, list of tables and figures and comprising key countries regions.**

We provide a detailed analysis of key players operating in the Rheumatoid Arthritis Drug Market:

The scope of the Report:

The report analyzes the key opportunities, CAGR, and Y-o-Y growth rates to allow readers to understand all the qualitative and quantitative aspects of the Rheumatoid Arthritis Drug market. A competition analysis is imperative in the Rheumatoid Arthritis Drug market and the competition landscape serves this objective. A wide company overview, financials, recent developments, and long and short-term strategies adopted are par for the course. Various parameters have been taken into account while estimating market size. The revenue generated by the leading industry participants in the sales of Rheumatoid Arthritis Drug across the world has been calculated through primary and secondary research. The Rheumatoid Arthritis Drug Market analysis is provided for the international markets including development trends, competitive landscape analysis, and key regions development status.

By Regions:

* North America (The US, Canada, and Mexico)

* Europe (Germany, France, the UK, and Rest of the World)

* Asia Pacific (China, Japan, India, and Rest of Asia Pacific)

* Latin America (Brazil and Rest of Latin America.)

* Middle East & Africa (Saudi Arabia, the UAE, , South Africa, and Rest of Middle East & Africa)

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Highlights of the Rheumatoid Arthritis Drug market study:

Speculations for sales:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Rheumatoid Arthritis Drug market. Additionally, it includes a share of every segment of the Rheumatoid Arthritis Drug market, giving methodical information about types and applications of the market.

Key point summary of the Rheumatoid Arthritis Drug market report:

This report gives a forward-looking prospect of various factors driving or restraining market growth.

It presents an in-depth analysis of changing competition dynamics and puts you ahead of competitors.

It gives a six-year forecast evaluated on the basis of how the market is predicted to grow.

It assists in making informed business decisions by creating a pin-point analysis of market segments and by having complete insights of the Rheumatoid Arthritis Drug market.

This report helps users in comprehending the key product segments and their future.

Strategic Points Covered in TOC:

Chapter 1: Introduction, market driving force product scope, market risk, market overview, and market opportunities of the global Rheumatoid Arthritis Drug market

Chapter 2: Evaluating the leading manufacturers of the global Rheumatoid Arthritis Drug market which consists of its revenue, sales, and price of the products

Chapter 3: Displaying the competitive nature among key manufacturers, with market share, revenue, and sales

Chapter 4: Presenting global Rheumatoid Arthritis Drug market by regions, market share and with revenue and sales for the projected period

Chapter 5, 6, 7, 8 and 9: To evaluate the market by segments, by countries and by manufacturers with revenue share and sales by key countries in these various regions

Finally, the report global Rheumatoid Arthritis Drug market describes Rheumatoid Arthritis Drug industry expansion game plan, the Rheumatoid Arthritis Drug industry knowledge supply, appendix, analysis findings and the conclusion. It includes a through explanation of the cutting-edging technologies and investments being made to upgrade the existing ones.

Report customization:

Market Research Intellect also provides customization options to tailor the reports as per client requirements. This report can be personalized to cater to your research needs. Feel free to get in touch with our sales team, who will ensure that you get a report as per your needs.

Get Complete Report @ https://www.marketresearchintellect.com/need-customization/?rid=202613&utm_source=NYH&utm_medium=888

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.

Contact Us:

Mr. Steven Fernandes

Market Research Intellect

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Tel: +1-650-781-4080

Tags: Rheumatoid Arthritis Drug Market Size, Rheumatoid Arthritis Drug Market Trends, Rheumatoid Arthritis Drug Market Growth, Rheumatoid Arthritis Drug Market Forecast, Rheumatoid Arthritis Drug Market Analysis sarkari result, sarkari exam, sarkari naukri

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Rheumatoid Arthritis Drug Market 2020 | Growth Drivers, Challenges, Trends, Market Dynamics and Forecast to 2026 - Cole of Duty

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Rheumatoid arthritis drug may have helped Kentucky native recover from COVID-19 – WYMT News

Thursday, May 7th, 2020

LEXINGTON, Ky. (WKYT/WYMT) As the COVID-19 pandemic continues to sweep the globe and death tolls keeps increasing, miraculous stories of survival are coming to light as well.

A Berea native who currently lives in Florida is currently fighting the disease and spoke to sister-station WKYT about her experience and how it changed her life.

"I feel like I am a walking miracle," says Kendra Wiggins.

Weeks following her diagnosis, she is now on the road to recovery.

As part of her effort, she signed up for an experimental double-blind drug trial after her diagnosis.

"It was just like breath in, cough, breath in, cough, that I couldn't get enough oxygen out," she says. "I took the 80 percent chance that I would get medication over the 20 percent chance that I wouldn't because with that 20 percent chance I still had what I thought was 50-50 with a ventilator."

The trial was for a drug known as Kevzara- typically used as a treatment for rheumatoid arthritis and consisted of three groups; some received a full dose, others received a half dosage, and the third group was given a placebo instead of the actual drug.

"I woke up about a half an hour into the medication with the worst heartburn ever. It was terrible. And all I could do was say 'Praise the Lord I got the real medication! If this had been saline, I wouldn't have felt anything, so I was so excited that I had heartburn. Never been excited for heartburn in my life," says Wiggins.

Wiggins says the treatment saved her life, and she hopes her experience will give hope to future COVID patients.

"Flattening the curve gave the medical community a chance to have guinea pigs, she says. I signed up willingly to be a human guinea pig and the information that they got from me is going to benefit you or someone you know."

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Rheumatoid arthritis drug may have helped Kentucky native recover from COVID-19 - WYMT News

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Arthritis flaring up during the COVID-19 pandemic? – Patch.com

Thursday, May 7th, 2020

While the COVID-19 pandemic dominates the headlines and, of course, continues to change our lives, but the calendar has changed to May, which is Arthritis Awareness Month. So let's talk a little bit about those aches and pains and what you can do about them.

Let's start with the basics - what is arthritis and do your aches and pains indicate arthritis? According to Dr. Adrienne Hollander, a rheumatologist with Virtua Health, osteoarthritis is usually found in the hands, thumbs, knees, hips and back and symptoms include:

You can get details on those symptoms and possible treatment on the Virtua website.

If so, the problem may not be arthritis, but trigger finger.

According toDr. Andrew Sattel, a Virtua hand surgeon, you don't need to shoot a gun to get trigger finger. It's a common hand condition that affects all kinds of people, and it's easily treated. Symptoms are usually worse in the morning and include finger stiffness and a popping or clicking sensation as you bend your finger.

Learn all about the symptoms and treatment for trigger finger here.

Speaking of your hand, do you have pain in your thumb? According to Dr. Eric Strauss, a Virtua hand surgeon, that could indicate basal thumb arthritis. He said it's important that you know you don't have to "just deal with it." This condition is treatable through conservative management, and in advanced cases, surgery.

Basal thumb arthritis is common in women age 40 and older, but men also are affected.

Learn about the symptoms and treatments for basal thumb arthritis here.

If you know you have arthritis, you should know that there are ways you can ease your discomfort without medication or clinical treatments.

Sounds simple, doesn't it? Get all the details on how to use these five steps to improve your quality of life.

At some point, arthritis pain may require some over-the-counter medication. Finding them isn't difficult, but sorting through the seemingly endless options can be daunting.

Dr. Samuel Weiner, a Virtua family physician, said over-the-counter medication options aren't as complicated as they may seem.

"It can get confusing with the number of brands available on the market," he said. "But there are only four major over-the-counter pain-killing products - aspirin, acetaminophen, ibuprofen and naproxen. Each has a different overall effect on the body."

While each of the four major products has its own array of individual brands, Dr. Weiner advises not getting wrapped up in the hype.

"I encourage my patients to look for generics," he said. "Generic over-the-counter pain relievers are less expensive, and they are just as effective as the name brands."

If you're looking for more information on Arthritis Awareness Month, you can check out this website.

Virtua has created a COVID-19 resource hub that includes up-to-date information about the pandemic, changes to the health system's operating guidelines - including visitation, ways to connect with care - including a self-assessment tool, and the answers to frequently asked questions.

There, you will also find useful information such as:

All of these and many more can be found on Virtua's resource hub.

You can get news, information, tips, and guidelines for healthy living on any health or lifestyle topic that's important to you - by subscribing to Virtua's Good Vibes newsletter. You can customize the content to match your interests and receive a monthly email that will help you be well, get well, and stay well.

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Arthritis flaring up during the COVID-19 pandemic? - Patch.com

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Dr. Zorba Paster: New information emerges on treating menopause, arthritis – The Spokesman-Review

Thursday, May 7th, 2020

By Dr. Zorba Paster For The Spokesman-Review

Keeping up to date that is the goal of every health care provider. We do it on the web, by reading books and journals, going to lectures, etc. Everyone has their own method.

Family doctors need 50 hours, minimum, of education each year to keep up our certification. Mayo Clinic has great meetings. They start super early, 7 a.m., and end at 11:30 p.m.

Now what would motivate you to go to something that early? Well, their meetings arent in Rochester, Minnesota, where Mayo is based. Theyre in Hawaii in Maui this year, to be exact.

What a shame, I know, but someone has to go. And this year it was me and fortunately it was before the coronavirus pandemic kept us home.

So with that introduction, let me share some of the updates I learned in no particular order.

The Heart and Estrogen/Progestin Replacement Study research from more than a decade ago seemed to show that women who take estrogen have more heart attacks. That basically was the death knell for the company that made Prempro, which was the most common estrogen preparation on the market with something like 85% of the share.

Well, guess what: Looking at the data now, and looking at what we know about heart disease, we may have been wrong.

Yes, there might be a small increase in heart attacks among women who take estrogen, but it might just be a subgroup of women. And a woman who suffers from menopausal symptoms might not exercise as much and might not sleep as well. She might not, well, she just might not be as healthy because she has menopausal symptoms.

For some lucky women, the symptoms never happen or go away in a few months. But for others, they can last seven to 10 years or even forever.

The most effective treatment, by far, is estrogen. The safest way is to take an estrogen patch, one designed for menopause, not for contraception. That one is much stronger, accompanied by micronized natural progesterone of 100 milligrams daily.

Now who should get estrogen? Thats a question I wont answer. Its one that every woman who still has symptoms should discuss with her health care provider.

Its important that they know the data has changed. So if you talk to them, ask if they have read the latest data. The estrogen used in the study, Prempro, is not the estrogen recommended today, and it was oral estrogen and not the estrogen patch. Those two facts may have played a major role into the outcome of the study.

Believe me if you go into that office armed with information you could print it out for them that will be an eye -opener. And, believe it or not, if they know youre looking over their shoulder with good, reliable scientific evidence, youll get better medical care.

I kid you not. Whether you like it or not, health literacy the ability to discuss your health issues scientifically with your provider pays off. Try it.

This was a very expensive gel back in the day, but its off patent now. This is an anti-inflammatory in a topical form. You can get a large tube for about $25.

Youll need a prescription for this. Studies have shown, shockingly in my eyes, this gel works as well as oral anti-inflammatories for many patients with arthritis.

The gel is as good as the pill but without the side effects of the pill no worries about stomach pain, bleeding ulcers, elevated blood pressure and kidney problems. It can cause your kidneys distress, that is if youre prone to it, older or on certain medications.

And its cheap, cheaper than CBD oil and much more effective, with efficacy proven by scientifically well-controlled studies.

My spin: It might not be as sexy as CBD, but its cheaper and it works. If you have joint pain, call your doctor and get it. Im using it for my hand arthritis, and my hands feel more like 55 than 72.

More updates next in the next column. Stay well.

Dr. Zorba Paster is a family physician and host of the public radio program Zorba Paster on Your Health. He can be reached at askzorba@doctorzorba.com.

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Dr. Zorba Paster: New information emerges on treating menopause, arthritis - The Spokesman-Review

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Essex mum’s 25-year battle with arthritis which became so bad she couldn’t hold her children – Essex Live

Thursday, May 7th, 2020

Rebecca Wynne has spent 25 years battling a painful condition which has often left her bedbound.

She was just 11-years-old when she was diagnosed with arthritis - a condition which largely affects adults in their 40s and upwards.

Now 35, she is still facing the daily challenge that arthritis brings. It became so bad that she couldn't even hold her kids when they were born.

When she tells people about her arthritis, the mum-of-two from Saffron Walden, Essex, is often faced with the look of shock in people's faces who simply cannot believe someone so young could have it.

This is the story from her diagnosis through to the struggles she has faced in her adult life.

Rebecca was 11 when she started suffering with pain and swelling in her joints.

Her parents took her to the GP and it was there that she was diagnosed with juvenile idiopathic arthritis.

She said: "It was a real shock. No one in my family had ever had it.

"It was just before I started secondary school.

"I wasn't a confident kid, so I didn't want anything that was going to make me stand out."

It is something that has, at some point, touched all our lives.

From cradle to grave, the National Health Service, and the incredible professionals within it who care for us, is a part of British life.

Today, more than ever, we should cherish those who dedicate themselves to our care, heedless of own health as they work tirelessly to care for people in the face of the coronavirus pandemic.

We have never needed our doctors, nurses, pharmacists and other carers more.

So lets show them some love, and create a living map of gratitude from every corner of Britain - visitwww.thanksamillionnhs.co.ukto drop a heart on the map wherever you are in the world.

By dropping a heart on the map, youre saying you appreciate the efforts undertaken daily in the NHS.

Thanks a million, NHS workers - we love you.

Her diagnosis meant she wasn't allowed to take part in PE lessons at school and she had to wear trainers rather than less comfortable school shoes.

At the time, she says didn't really notice the impact it had on her. But as an adult, she has been able to fully take stock on the debilitating effect it's had on her life.

"I have had to bend my life around it," she said. "Of course to me it's not weird at all, it's just my life.

"Pretty much everyone I meet that finds out can't believe that I have arthritis. That has been the challenge since I was 11."

Her arthritis affects every single joint in her body, though some hurt more than others.

But it was after she gave birth to her second child, Lottie, three years ago that Rebecca's hips became really painful.

She already had one daughter, Emilia - who is now five - so had no reason to believe having another baby would make her condition worse.

But after Lottie came along, Rebecca couldn't bend down and was in constant agony, so much so that she was left unable to pick up her children.

It was heartbreaking for her and left her feeling like she couldn't fulfill her duties as a mother.

She added: "This has been the hardest part for me. After I had Lottie, the arthritis seemed to take control of my life.

"I couldn't take care of my children. It felt like all of a sudden I couldn't be the mum I wanted to be, I couldn't pick them off or doing anything for them.

"I could barely leave the house, not being able to care for my children was heartbreaking."

Being so young, Rebecca says her girls can't understand what is happening to their mum, but says they are amazing.

"They are very demanding, as young children are, but they don't understand what I am really suffering with," she said.

"Lottie has had to deal with this all as a toddler.

"It's different when it is just affecting you but as a parent it becomes a burden on your children.

"I feel a guilt that never goes away."

Rebecca also never thought she would have to depend so much on someone like she has with her husband, Tom.

Rebecca explained: "I have always been fiercely independent.

"All of a sudden I was being cared for by my husband.

"Perhaps I was a bit naive to live day by day, I hadn't considered how it was damaging my joints.

"That day came and it was awful."

Rebecca was offered a double hip replacement, a huge operation for someone to have so young.

The operation has dramatically improved her quality of life and she is no longer in the constant pain she once was.

Rebecca said: "It ate away at my hips so they had to be replaced.

"My hips are great now, they are my best joint.

"The hip replacement has been life changing, it was amazing."

Rebecca also suffers with her knees and has had to go to hospital to have them drained more times that she can remember.

She explained: "I have severe damage in my feet and ankles, I can't walk very far.

"Some days it is bearable but others it is horrendous.

"I am in pain every day.

"It feels like a throbbing, like my joints are on fire."

"The damage gets worse throughout the day.

"I'm always in some sort of pain, the daily pain from my feet and ankles is a joke."

Unfortunately there is not a common operation available for her feet like her hip surgery.

For now, Rebecca is focusing on controlling the pain.

The inflammatory part of arthritis is what tends to affect Rebecca in the mornings.

She wakes up stiff, puffy and in pain, but her medication is very effective at calming it down.

As the day goes on the joint pain only gets worse.

But one of the hardest parts about her condition isn't the pain it causes - it's the lack of understanding.

Although arthritis is very well known, and quite common, people aren't used to hearing about it in a young person.

However, two thirds of the 10 million people in the UK with arthritis are aged under 65.

She's even had people accuse her of lying about her condition during her commute to and from work.

She said: "I used to commute to work in London, that was hell.

"At that time I looked normal, but I was in so much pain.

"There were never any seats on the train home.

"I'm not someone who shouts about my condition, but sometimes I had to as I needed to sit down.

"Some of those times where I would speak up I would have people tell me that I couldn't have arthritis and that I was lying."

The lack of understanding of her illness also caused problems in Rebecca's work.

She is an architect and says that past employers have been good to her, though she doesn't think they fully understand what she goes through.

Rebecca explained: "It's difficult for people to understand. One day I will seem okay as it's under control, but the next I will be bed-ridden.

"I don't like having to answer for my condition.

"It feels like you are making excuses all of the time, when you just can't physically get out of bed."

For the past few years, Rebecca has been self-employed, meaning she can manage her work and her illness alongside each other.

Taking the step to work for herself was a big leap, but Rebecca says it was what she needed to do.

She said: "I can now take on as much work as I can manage.

"Working for myself was the right decision for me by far."

Whilst the coronavirus pandemic continues, we are all being told to stay at home where we can.

For Rebecca, Covid-19 is more even more serious.

The drugs she takes for her arthritis are immuno-suppressing, meaning she is more at risk of contracting the virus because of her weakened immune system.

She and her family are having to isolate together to protect her health and means none of them can leave the house.

Rebecca said: "The fear is huge. Being told that you are extremely vulnerable is horrible.

"It means my children can't go out, that's particularly hard.

"I feel guilty about it."

Her day-to-day life hasn't changed much, as she is often trapped indoors because of her illness.

The big difference is that her children are at home with her all of the time.

She said: "I feel lucky that I have this time with my children, but for us this can't be a short-term thing.

"The girls aren't going to be able to go to school for a long time.

"I'm having to take it day by day.

"The nature of my disease is that I have stress-related flare ups so I try to not let it get to me.

"I stay as positive as I can otherwise I could turn bitter."

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Rebecca has now joined forces with the charity Versus Arthritis to help raise awareness for arthritis.

Their latest campaign It's not alright, it's arthritis aims to widen people's understanding that arthritis can affect anyone.

The charity are keen to get rid of the stigma that arthritis is just 'wear and tear'.

Rebecca said: "It feels amazing to have someone in your corner fighting for awareness.

"It's just a relief to know they are there.

"So many people will be turning to them right now as they they don't want to add strain to their GP.

"The charity will also be under pressure like never before, so it's so important that the public understand their work."

A spokesperson for Versus Arthritis said: "We just want to raise awareness and dispel the myth that it's part of aging.

"We often run campaigns but this one is about asking the public to pledge support for those living with arthritis.

Continue reading here:
Essex mum's 25-year battle with arthritis which became so bad she couldn't hold her children - Essex Live

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Blockade of Discoidin Domain Receptor 2 as a Strategy for Reducing Inflammation and Joint Destruction in Rheumatoid Arthritis Via Altered…

Thursday, May 7th, 2020

OBJECTIVE:

This study was undertaken to uncover the pathophysiologic role of discoidin domain receptor 2 (DDR-2), a putative fibrillar collagen receptor, in inflammation promotion and joint destruction inrheumatoid arthritis(RA).

In synovial tissue from patients with RA and from mice with collagen antibody-inducedarthritis(CAIA) (using Ddr2-/-and DBA/1 mice), gene and protein expression levels of DDR-2, interleukin-15 (IL-15), and Dkk-1 were measured by quantitative reverse transcription-polymerase chain reaction, Western blotting, and immunohistochemistry. Gene knockdown of DDR2 in human RA fibroblast-like synoviocytes (FLS) was conducted via small interfering RNA. Interaction between the long noncoding RNA H19 and microRNA 103a (miR-103a) was assessed in RA FLS using RNA pulldown assays. Cellular localization of H19 was examined using fluorescence in situ hybridization assays. Chromatin immunoprecipitation and dual luciferase reporter assays were applied to verify H19 transcriptional and posttranscriptional regulation by miR-103a.

DDR2 messenger RNA (mRNA) expression was significantly associated with the levels of IL-15 and Dkk-1 mRNA in the synovial tissue of RA patients (r2= 0.2022-0.3293, all P < 0.05; n = 33) and with the serum levels of IL-15 and Dkk-1 in mice with CAIA (P < 0.05). In human RA FLS, activated DDR-2 induced the expression of H19 through c-Myc. Moreover, H19 directly interacted with and promoted the degradation of miR-103a.

These results indicate a novel role for activated DDR-2 in RA FLS, showing that DDR-2 is responsible for regulating the expression of IL-15 and Dkk-1 in RA FLS and is involved in the promotion of inflammation and joint destruction during pathophysiologic development of RA. Moreover, DDR-2 inhibition, acting through the H19-miR-103a axis, leads to reductions in the inflammatory reaction and severity of joint destruction in mice with CAIA, suggesting that inhibition of DDR-2 may be a potential therapeutic strategy for RA

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Blockade of Discoidin Domain Receptor 2 as a Strategy for Reducing Inflammation and Joint Destruction in Rheumatoid Arthritis Via Altered...

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