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Archive for the ‘Arthritis’ Category

Modestly Elevated Serum Procalcitonin Levels in Patients with Rheumatoid Arthritis Free of Active Infection – DocWire News

Thursday, October 22nd, 2020

Background and objectives: To investigate the serum procalcitonin (PCT) levels among patients with rheumatoid arthritis (RA) without active infection compared with healthy controls and to understand the relationship of PCT with RA disease activity, and treatment received by patients.

Materials and Methods: Patients aged 20 years and above with clinician-confirmed diagnosis of RA and healthy volunteers were included during regular outpatient visits, and those with active infection symptoms and signs were excluded. RA disease activity was measured using the Disease Activity Score-28 for Rheumatoid Arthritis with erythrocyte sedimentation rate (DAS28-ESR). Medications received by the patients were also recorded.

Results: A total of 623 patients with RA and 87 healthy subjects were recruited in this study. The mean PCT were significantly higher in patients with RA (6.90 11.81 10-3ng/mL) compared with healthy controls (1.70 6.12 10-3ng/mL) (p< 0.001) and the difference remained statistically significant after adjusting for age and sex. In addition, multiple linear regression analysis showed that a lower rank-transformed PCT serum level was significantly correlated with the use of biologics (p= 0.017) and a high DAS28-ESR score (p = 0.028) in patients with RA.

Conclusion: Patients with RA have a significantly higher serum PCT levels compared with healthy controls. The use of biologics and an active RA disease activity were associated with a lower level of PCT in patients with RA. Further investigation is required to determine the optimal cutoff value of PCT among patients with RA and its association with disease activity and biologic usage.

Keywords:disease activity; disease activity index; infection; procalcitonin; rheumatoid arthritis.

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MRI following medial patellofemoral ligament reconstruction: assessment of imaging features found with post-operative pain, arthritis, and graft…

Thursday, October 22nd, 2020

Objective:To assess MR features following MPFL reconstruction and determine their influence on post-operative pain, progressive arthritis, or graft failure.

Materials and methods:Retrospective study on 38 patients with MPFL reconstruction and a post-operative MRI between January 2010 and June 2019. Two radiologists assessed MPFL graft signal, graft thickness, femoral screw, femoral tunnel widening, and patellofemoral cartilage damage. The third performed patellofemoral instability measurements. All three assessed femoral tunnel position with final result determined by majority consensus. Imaging findings were evaluated in the setting of post-operative pain, patellofemoral arthritis, and MPFL graft failure including need for MPFL revision. Statistics included chi-square, Fishers exact test, t test, and kappa.

Results:Mean graft thickness was 6.0 1.8 mm; 24% of the grafts were diffusely hypointense. Mean femoral tunnel widening was 2.5 1.8 mm; 34% of the femoral screws were broken or extruded. Fifty-two percent of the patients had no interval cartilage change. Non-anatomic femoral tunnels were found in 66% of patients, including in all 9 patients requiring revision MPFL reconstruction (p = 0.013). Revised MPFL grafts had more abnormal femoral screws compared to those that did not (67% vs. 24%) (p = 0.019). Other MR features did not significantly influence the evaluated outcomes.

Conclusion:The need for revision MPFL reconstruction occurs more frequently when there is a non-anatomic femoral tunnel and broken or extruded femoral screws. The appearance of the MPFL graft itself is not an influencing factor for post-operative pain, progression of patellofemoral arthritis, or graft failure.

Keywords:Graft failure; MPFL reconstruction; MRI; Medial patellofemoral ligament; Post-operative knee.

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Impact of Enthesitis on Psoriatic Arthritis Patient-Reported Outcomes and Physician Satisfaction with Treatment: Data from a Multinational Patient and…

Thursday, October 22nd, 2020

Introduction:Enthesitis is a core outcome domain assessed in psoriatic arthritis (PsA) clinical trials. Limited evidence describes the impact of enthesitis on patient-reported outcomes (PROs) and physician satisfaction with current treatment options. The objective of this analysis is to characterize the impact of enthesitis on PROs and physician satisfaction with currently available treatment in clinical practice settings.

Methods:Cross-sectional survey of rheumatologists, dermatologists, and their consulting patients with PsA in Australia, Canada, European Union (EU5), and the USA conducted in 2018. Physicians assessed current presence and severity of enthesitis, overall disease severity, other symptoms experienced, and their satisfaction with the current treatment. PsA participant self-reported data included current pain level, EQ5D, Psoriatic Arthritis Impact of Disease (PsAID12), Health Assessment Questionnaire Disability Index (HAQ-DI), and Work Productivity and Activity Impairment Index (WPAI-SHP). Bivariate descriptive analyses were conducted to describe features and outcomes in participants with and without enthesitis.

Results:Rheumatologists (454) and dermatologists (238) provided information for 3157 participants with PsA. Mean participant age was 49.2 years, and 45.9% were female. Enthesitis was present currently in 6.5% (205) of participants with PsA. Those with enthesitis had worse overall disease severity compared to those without enthesitis (12.2% vs 2.2% severe) and had more extraarticular manifestations, including nail psoriasis, dactylitis, and sacroiliitis. Enthesitis was associated with more pain, worse quality of life (QoL), increased disability, and a negative impact on work. Participants with enthesitis had higher NSAIDs and opioid pain medication use but similar biologic use. Physicians were significantly less satisfied with current PsA treatment in participants with enthesitis versus without enthesitis.

Conclusions:Participants with psoriatic arthritis with enthesitis experienced significantly higher disease burden than those without enthesitis but were not more likely to receive advanced therapies. Physicians were significantly more dissatisfied with treatment in patients with enthesitis than in those without it.

Keywords:PROs; Patient-reported outcome; Psoriatic arthritis; Real-world evidence; Satisfaction.

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Health: The alternative ways to ease joint pain and arthritis – The Sunday Post

Thursday, October 22nd, 2020

Arthritis means sore joints and often lots of painkillers to keep the aches at bay. But there could be alternatives to popping prescription pills every day, according to experts.

Exercise, weight loss and supplements, such as vitamin D and rosehip, could help manage the often agonising symptoms of joint health, it is claimed. Dr Alastair Dickson, a GP with an interest in arthritis, said joint problems are common.

They can be caused by lots of things and can be short-term pain or more long term, he said. Acute pain is often caused by knocks, sprains and other injuries. Typically, this pain will get better over a number of days or weeks.

Persistent joint pain often results from more chronic processes related to trauma and wear and tear, such as osteoarthritis, and inflammatory arthritis.

Osteoarthritis, Dr Dickson explains, is the response of your body trying to heal your joints and can have a significant impact on the lives of sufferers. The condition is most common in the over 40s, and in people who have suffered more trauma in their joints. It can affect any joint, but the most common are hips, knees, ankles, hands, fingers and neck.

Joint pain is different for each patient, Dr Dickson said.

Commonly osteoarthritis in the large joints (such as your knees and hips) affects your mobility whilst osteoarthritis of your shoulders, hands and fingers can affect your ability to lift and open and close things making everyday tasks such as dressing difficult.

Neck osteoarthritis can make movement such as looking up awkward and painful, he said.

In Scotland it is estimated that 16.6% of people aged over 45 years suffer with knee osteoarthritis and 10.1% have hip osteoarthritis.

The symptoms of osteoarthritis, especially pain, tend to develop slowly and build-up in severity over time, typically years, Dr Dickson explained. If you have pain from osteoarthritis the symptoms are individual to you. Treating everyone in the same way doesnt work.

When it comes to treatment, non-weight bearing exercise and weight loss are considered crucial. And painkillers are often prescribed but Dr Dickson says alternatives, such as physiotherapy, cognitive behavioural therapy and evidence-based supplements, can help reduce this long-term reliance on pain relief. Over recent years, evidence has been accumulating that overuse of painkillers is problematic and doesnt necessarily cure the pain, he said.

Paracetamol is often insufficient for the pain on its own. To complicate matters further drugs that work for one person dont necessarily work for someone else. There is currently a very large change in practice being suggested with the National Institute for Health and Care Excellence (NICE) draft guidance advising most painkillers for chronic pain should not be used long term as they are ineffective.

The answer, Dr Dickson says, could be to look at the causes of pain and consider supplements where there is good evidence that they are safe and clinically effective. Unfortunately many supplements, such as glucosamine or chondroitin products, rubefacient creams (deep heat creams) are currently not considered to be either clinically or cost-effective following reviews by the NHS.

However, increasing vitamin D has been shown to reduce muscular pain and evidence suggests rosehip may be effective in relieving some symptoms. Dr Dickson, who advises a company who supports GOPO, a rosehip-containing medication, explained: A summary analysis of three clinical trials found that rosehip-containing medications are clinically effective in reducing pain. Studies have found that some rosehip compounds appear to have anti-inflammatory properties and potential benefits to cartilage but there have been no clinical trials to confirm this in patients.

Some patients use rosehip as an alternative to paracetamol. Its not available on the NHS but can be bought over the counter from a chemist. NICE is currently reviewing its osteoarthritis guidance and there should be updated guidance next year. Hopefully NICE will include rosehip compounds in its updated analysis.

He added: I use painkillers but over recent years the evidence has changed for why and how we should be using them: I now increasingly advise that they are to help you to start to mobilise by reducing not curing your pain.

We use the lowest dose possible for the shortest time.

This doesnt mean never taking them but rather educating the patient so they become the expert and, armed with the information, they can become more in charge of how best to manage their pain and when to use painkillers.

Many over-the-counter supplements are thought to be helpful for arthritis sufferers. Here are some you could try:

Glucosamine

Helps keep the cartilage in joints healthy and may have an anti-inflammatory effect. Natural glucosamine levels drop as people age.

Chondroitin sulfate

Often used with glucosamine as an osteoarthritis treatment, researchers found that chondroitin appeared to reduce pain, increase joint mobility, and decrease the need for painkillers.

Omega 3 fatty acids

Found in fish oil, Omega 3 fatty acids encourage the body to produce chemicals that help control inflammation. May help ease stiffness for rheumatoid arthritis patients.

Curcumin

Active ingredient of turmeric, it has anti-inflammatory properties and provides relief for people with osteoarthritis of the knee.

Green tea

Packed with polyphenols, antioxidants believed to reduce inflammation and slow cartilage destruction.

Vitamin D

Important for keeping bones strong and preventing injuries from falls. Research shows that people with low levels of vitamin D may have more joint pain.

Ginger

May be beneficial in managing the inflammation and pain of arthritis, due to anti-inflammatory effects.

Rosehip

Contains polyphenols and anthocyanins, which are believed to ease joint inflammation and prevent damage.

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Factors associated with treatment satisfaction in patients with rheumatoid arthritis: data from the biological register RABBIT – DocWire News

Thursday, October 22nd, 2020

Objective:To assess satisfaction with the effectiveness and tolerability of treatments in patients with rheumatoid arthritis (RA).

Methods:Patients from the RABBIT register, starting a biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drug (DMARD), or a conventional synthetic (cs)DMARD treatment after 1 csDMARD failure, were included. Treatment satisfaction was measured after 1 year of treatment in four categories and binarised for analysis. Logistic regression models were performed to calculate ORs for factors associated with treatment satisfaction.

Results:Data of 10 646 patients (74% women, mean 58 years) were analysed. At baseline, 55% of the patients were satisfied with the efficacy and 68% with the tolerability of their previously given treatments. After 1 year, 85% of the patients were satisfied with treatment effectiveness and 90% with tolerability. Baseline satisfaction (OR 2.98, 95% CI 2.58 to 3.44), seropositivity (OR 1.36, 95% CI 1.17 to 1.57), reduction of DAS28 (OR 1.38, 95% CI 1.31 to 1.46) and pain (OR 1.26, 95% CI 1.22 to 1.31), and the improvement of physical capacity (OR 1.22, 95% CI 1.17 to 1.29) were positively associated with treatment satisfaction at follow-up while glucocorticoids (GCs) >5 mg/day, depression, fibromyalgia, obesity, prior bDMARDs and therapy changes were negatively associated. The impact of GC on satisfaction was dose-dependent, becoming strongest for GC >15 mg (OR 0.24, 95% CI 0.16 to 0.34). A 5 mg/day reduction within 12 months was positively associated with satisfaction regarding efficacy (OR 1.19, 95% CI 1.11 to 1.27) and tolerability (OR 1.11, 95% CI 1.03 to 1.21).

Conclusion:Most patients were satisfied with their treatments effectiveness and tolerability after 1 year of treatment. Tapering GCs was positively associated with the improvement of patients satisfaction.

Keywords:Arthritis; Biological Therapy; Patient Reported Outcome Measures; Rheumatoid.

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SIMPONI ARIA (golimumab) for the Treatment of pJIA – Clinical Trials Arena

Thursday, October 22nd, 2020

SIMPONI ARIA (golimumab) is a fully human monoclonal antibody used for the treatment of active polyarticular juvenile idiopathic arthritis (pJIA). Credit: Janssen Biotech, Inc. The 4ml single-use vial of SIMPONI ARIA contains 50mg of golimumab. Credit: A2-33. SIMPONI ARIA acts as a tumor necrosis factor (TNF)-blocker.

SIMPONI ARIA (golimumab) is a fully human anti-tumour necrosis factor (TNF) alpha monoclonal antibody.

It is indicated for the treatment of moderate-to-severe active rheumatoid arthritis (RA) and active ankylosing spondylitis (AS) in adult patients, as well as active polyarticular juvenile idiopathic arthritis (pJIA) and active psoriatic arthritis (PsA) in patients aged two years and older.

SIMPONI ARIA is available in a single-use vial as a colourless to a light-yellow solution in 50mg / 4ml (12.5mg / ml) dosage strength for intravenous administration.

Discovered and developed by Janssen Biotech, golimumab was initially approved as a subcutaneous injection under the trade name Simponi by the US Food and Drug Administration (FDA) for the treatment of RA, PsA and AS in adult patients in 2009.

SIMPONI was approved in Europe for the treatment of moderate-to-severe RA, active and progressive PsA, severe, active AS, active ulcerative colitis, severe active non-radiographic axial spondyloarthritis and pJIA.

In July 2013, the intravenous form of golimumab obtained FDA approval under the trade name Simponi Aria for the treatment of moderate-to-severe active RA in combination with methotrexate (MTX).

The company submitted two supplemental biologics license applications (sBLAs) for Simponi Aria to the FDA for the treatment of PsA and AS in adult patients in December 2016. The applications were approved in October 2017.

The FDA also received two sBLAs for Simponi Aria for the treatment of active pJIA and PsA in paediatric patients in April 2020. The drug was approved for the indications in September 2020.

SIMPONI ARIA is marketed in 24 countries for one or more of the aforementioned indications.

Juvenile idiopathic arthritis (JIA), previously known as juvenile rheumatoid arthritis, is an arthritis-like inflammatory condition in children characterised by joint swelling, stiffness and pain, persistent for at least six weeks.

The polyarticular form of JIA is most common and is characterised by inflammation in more than four joints, closely resembling adult RA.

PsA is a chronic inflammatory disease characterised by both joint inflammation and skin lesions associated with psoriasis. PsA in paediatric patients is one of the rarest forms of JIA, observed in 2% to 11% of JIA patients.

Other characteristics of psoriatic arthritis include finger and nail defects or complications with the eye.

Golimumab is an anti-TNF biologic agent that binds to soluble and transmembrane bioactive forms of human TNF-alpha, a cytokine protein whose overproduction in the body leads to several chronic inflammatory diseases.

Inhibition of the interaction of TNF-alpha to its receptors inhibits its biological activity.

FDA approval of SIMPONI ARIA for pJIA is based on results from the open-label, multi-centre, phase three clinical trial, GO-VIVA.

SIMPONI ARIA is available in a single-use vial as a colourless to a light-yellow solution in 50mg / 4ml (12.5mg / ml) dosage strength for intravenous administration.

The trial evaluated the safety and efficacy of SIMPONI ARIA in 127 patients with pJIA aged two years to 17 years, following MTX treatment for at least two months.

The efficacy of the drug was consistent with responses in adult patients with RA through 52 weeks.

SIMPONI ARIAs pharmacokinetic (PK) exposure was consistent with the two pivotal phase three clinical trials in adult patients with moderate-to-severe active RA and active PsA.

The safety profile established for SIMPONI ARIA in paediatric patients was also consistent with the results in adult RA and PsA patients.

Common side-effects of SIMPONI ARIA reported in patients during the clinical trial are viral infections, upper respiratory tract infection, increased levels of alanine aminotransferase and aspartate aminotransferase, decreased neutrophil count, rash, bronchitis and high blood pressure.

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The Best and Worst Foods to Eat When You Have Arthritis – LIVESTRONG.COM

Thursday, October 22nd, 2020

An arthritis diet should focus on anti-inflammatory foods like fruits and vegetables.

Image Credit: SDI Productions/E+/GettyImages

There's no magic bullet when it comes to treating arthritis, unfortunately. But if you have the condition, you might find some symptom relief by changing what you eat.

Here's the breakdown on how diet and arthritis are linked, and the best and worst foods to eat for joint pain, stiffness and swelling.

The Inflammation Connection

There are more than 100 types of arthritis, but each is marked by chronic inflammation in the joints that can cause swelling and pain, according to the Mayo Clinic.

Acute or short-term inflammation is actually a healthy response that helps protect the body. A fever, which helps you fight off infection, is an example of acute inflammation. This type of inflammation goes away when the threat to the body is gone, according to a December 2019 paper published in Nature Medicine.

Chronic or long-term inflammation is that same response, but all the time. You don't go walking around with a fever 24/7, but inflammation is present in your body to a lesser extent. This chronic inflammation is linked to conditions such as heart disease, type 2 diabetes and metabolic syndrome, according to the Nature Medicine paper.

"Diet can absolutely impact arthritis be either exasperating inflammatory symptoms or by quieting inflammation."

Inflammation occurs for different reasons across the various types of arthritis. In osteoarthritis, the most common type, inflammation is caused by wear and tear on the joints, according to the Centers for Disease Control and Prevention (CDC). Rheumatoid arthritis (RA), on the other hand, is an autoimmune disease, so inflammation occurs because the body mistakenly attacks the joints, per the CDC.

Tamping down that inflammatory response can help manage the pain and other uncomfortable symptoms of arthritis, and that's where your diet comes in: Certain foods can increase or decrease inflammation in the body.

"At the root of the pathology of arthritis is chronic and unchecked inflammation," says Liz Wyosnick, RDN, dietitian and owner of Equilibriyum in Seattle, Washington. "Diet can absolutely impact arthritis be either exasperating inflammatory symptoms or by quieting [inflammation]."

Foods to Limit or Avoid With Arthritis

According to the Arthritis Foundation, the following foods can trigger or worsen inflammation:

This really means "added sugar," which is sugar added to food during processing (think: sweetened beverages like soda and snack foods). You should limit your added sugar to 6 teaspoons per day for women and children, and no more than 9 teaspoons per day for men, according to the American Heart Association.(For reference, 6 teaspoons is about 25 grams and 9 teaspoons is about 38 grams; a 12-ounce can of Coke has 39 grams of sugar.)

Limiting the amount of saturated fat in your diet means eating less red meat, whole-fat dairy, butter and cheese.

Decreasing saturated fats in the diet and replacing them with monounsaturated fats (like nuts, avocado and vegetable oils) may help reduce the progression of knee osteoarthritis, according to March 2017 research published in Arthritis Care and Research.

These are manmade fats that the Food and Drug Administration banned as an ingredient in foods in 2015. However, they're still found in very small amounts in processed baked good and shelf-stable foods that have "partially hydrogenated" in the ingredients list. Here are six foods to avoid.

Omega 6s aren't bad per se, but the issue is when the ratio of omega-6s to omega-3s is off. The goal is to lower the ratio, which means less omega-6 fatty acids and more omega-3s to help reduce the pain associated with arthritis inflammation, according to a February 2018 article published in the Clinical Journal of Pain.

Try to steer clear of processed meats and opt instead for seafood and leaner cuts of grass-fed meat.

Aim to eat a 3- to 6-ounce serving of fatty fish two to four times a week, per the Arthritis Foundation, and opt for fish that are relatively low in mercury, such as salmon, sardines, Atlantic mackerel and black cod.

Gluten is the protein found in wheat, rye and barley, while casein is a protein found in dairy foods. If you have a sensitivity to either of these, this could trigger an inflammatory response.

The link isn't entirely clear, but some individuals with rheumatoid arthritis have found relief by sticking with a gluten-free vegan diet, according to February 2018 research published in Open Rheumatology Journal.

"The underlying theory is that when you go on a plant-based diet, you cut back on animal products (dairy and meat), and hence, exclude most of the foods that promote inflammation, which helps control your RA symptoms," Febin Melepura, MD, medical director at the Sports & Pain Institute of New York, tells LIVESTRONG.com. "In contrast, diets high in animal products and low in fiber might aggravate your arthritis or cause more flare-ups."

What to Eat When You Have Arthritis

Fatty fish like salmon are rich in inflammation-fighting omega-3s.

Image Credit: kajakiki/E+/GettyImages

A diet focused on easing arthritis symptoms typically includes foods that can help decrease inflammation, not promote it. But "there's no one-size-fits-all approach," Dr. Melepura says. "What works for one may not work for another."

With that in mind, here are some loose guidelines to follow, but be sure to adjust where you need to based on your individual symptoms.

It's no secret that fruits and vegetables are recommended for good health, but their role in helping relieve arthritis pain lies in special compounds called phytochemicals, which are responsible for fighting inflammation.

"I would particularly recommend including fruits such as pomegranates, blueberries, raspberries and strawberries," Dr. Melepura says, "as they are a rich source of polyphenols including anthocyanins, quercetin and various types of phenolic acids. All these compounds are widely known for their potent anti-inflammatory effects."

Herbs and spices are also a source of anti-inflammatory compounds.

"Parsley, basil, cilantro, gingerroot, cinnamon and turmeric are some of the most nutrient-dense and anti-inflammatory foods available, so I guide people to incorporate these at most meals," Wyosnick says.

These special fats are found mainly in fish, but you can also find them in walnuts, flaxseeds and chia seeds. Dr. Melepura calls these "joint-friendly fats" and says "studies show that consumption of omega-3 fats lowers the levels of two inflammatory proteins, which are C-reactive protein (CRP) and interleukin-6." It should be noted, though, that this has been shown in people with fairly serious diseases, so the research may not translate for those with minor arthritis.

Olive oil is a major component of the Mediterranean diet, which is filled with fruits and vegetables, fish, legumes and nuts. Olive oil is a monounsaturated fat and researchers believe it's one of the reasons why the Mediterranean diet is good for reducing inflammation.

Extra-virgin olive oil specifically has been shown to improve gut health and also cut back on inflammation in the body, according to August 2019 research published in Nutrients.

To help tame arthritis inflammation, fill your plate with fruits and vegetables, lean proteins, fatty fish and healthy fats, such as olive oil. Cut back on sugar and saturated fats, and avoid trans fats completely.

Navigating Your Arthritis With Diet

If your specific type of arthritis has you confused about which type of foods you should eat, don't let that worry you. "An anti-inflammatory eating pattern can be perfectly safe for any type of arthritis," Wyosnick assures.

If you have food allergies or want to confirm an allergy or intolerance that may be aggravating your arthritis pain, speak with your doctor.

In addition, a registered dietitian can help you evaluate your current diet, remove troublesome foods from your diet and add in foods that may help provide some relief.

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Man drank speed to help with arthritis – Observer

Thursday, October 22nd, 2020

A GLADSTONE man caught drug driving said he drank speed to help with his arthritis.

Mark Leslie Gordon, 55, pleaded guilty in Gladstone Magistrates Court on Monday to drug driving.

He was intercepted on the Dawson Highway, West Gladstone, on July 25 where he returned a positive drug test.

Further tests showed the presence of MDMA and methamphetamine.

Gordon was caught once again on September 6 on Campbell St.

He told police he drank speed to help with his arthritis.

Further tests showed the presence of THC and meth in his system.

During a search, police located a white crystal substance which weighed less than 1g, which Gordon said was speed.

Defence lawyer Cassandra Ditchfield said her client had been on a waiting list for five years to see a surgeon to treat his rheumatoid arthritis which caused him pain.

She said a friend had suggested he try using the drug to treat the pain as he was not willing to use prescription pain killers due to a family history of liver failure.

She asked the court to consider Gordon had no offending for 11 years.

Gordon was fined $1000 and disqualified from driving for four months.

Convictions were recorded.

Read more drug driver stories:

Mechanic loses licence for half a year

Gladstone man stopped drug driving on way home from library

Recreational user had drugs left over from party

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Photo of Try these three natural remedies to manage arthritis pain – Kempton Express

Thursday, October 22nd, 2020

Arthritis affects over 350 million people in the world.

It is also a leading cause of disability and can affect mobility and interrupt peoples ability to perform simple daily tasks.

World Arthritis Day was on October 12, which aimed to raise awareness about rheumatic and musculoskeletal diseases. Although strides have been made to find suitable treatments, many continue to suffer from debilitating pain.

Owner and founder of The Harvest Table, Catherine Clark, said there are natural remedies which can help manage symptoms associated with arthritis.

There is no cure for arthritis, but if you support your body with the right foods and supplements, you can alleviate some of the pain so that it doesnt become a hindrance in your daily life, said Clark.

Clark added that arthritis can affect ones energy levels, cause pain, and is a direct result of a loss of collagen in the bones.

The key is to find solutions that will help you feel less fatigued, while also managing pain and replenishing the collagen lost, she said.

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Clark offers three natural remedies to manage arthritis pain:

Anti-inflammatory foodsArthritis fatigue is real, and according to the Arthritis Foundation, unchecked inflammation and pain largely contribute to your energy levels, along with certain medications that can cause drowsiness.Boosting your energy starts with nourishing your body with the right foods, especially those with high anti-inflammatory properties that help your bodies repair process. This will not only alleviate pain but will reduce the inflammation in your body. To effectively manage your arthritis, reduce the amounts of processed foods and saturated fats as these will only further contribute to your symptoms. Instead, choose fresh fruits and vegetables, especially green vegetables and berries. Also include fish and nuts, which both contain high anti-inflammatory properties.

Slow and gentle movementMovement is a critical part of recovery when addressing the symptoms of arthritis as it retains the suppleness of your joints. Various low impact movements can specifically tackle flexibility, strength and generally support your joints to prevent injury. Prolonged lack of movement can lead to chronic stiffness that results into joint immobility which will impact your ability to complete daily activities. Yoga is an effective solution as it reduces joint pain and also eases stress, tension and promotes better quality sleep.

Collagen-rich supplementsCollagen consists of protein building blocks, otherwise known as amino acids, which aid in cushioning our joints. When you have arthritis, this cushioning diminishes which then affects your cartilage and leads to your bones rubbing against each other without protection. Supplements like Bone Broth and Collagen granules help replenish the collagen content in your body. Bone Broth is a natural anti-inflammatory, so when you have it as part of your diet, you benefit in more ways than one. Collagen granules can help reduce both osteoarthritis and rheumatoid arthritis joint pain, improve flexibility, and helps form new bones. Although all the collagen you ingest does not go straight to your bones, increasing your intake makes them readily available for your body tissues.

Natural remedies are meant to support your body so that you can better manage pain and other symptoms associated with arthritis. The idea is to implement small and manageable changes that contribute to you feeling better and having the energy and ability to get through the day without pain getting in the way, Clark concludes.

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Arthritis drug to be investigated as possible treatment for vascular dementia – Latest – News – The – University of Sheffield News

Thursday, October 22nd, 2020

16 October 2020

Scientists from the University of Sheffield and University of Manchester have been awarded 265,000 from the British Heart Foundation, to investigate the links between vascular dementia and heart disease, and test whether a drug currently used to treat arthritis could also be used as a treatment for vascular dementia.

Vascular dementia is common, accounting for 15 percent of all cases of dementia. Caused by an impaired blood flow to the brain, symptoms of vascular dementia include confusion, slow-thinking, and changes in mood and behaviour.

Heart disease is a known risk factor for vascular dementia, and preliminary research by the Sheffield scientists has shown that blood flow in the brain is substantially affected by heart disease. The new study will continue this research to examine in more detail how heart disease and vascular dementia interact together, potentially making the disease burden worse.

The project will also investigate an anti-inflammatory treatment to reduce neuroinflammation in the brain and test whether this slows down, or reduces the severity of, vascular dementia.

Led by Professor Sheila Francis, from the University of Sheffields Department of Infection, Immunity, and Cardiovascular Disease, the project brings together the disciplines of cardiovascular biology and pathology, neurovascular function and neuropathology.

Dr Jason Berwick and Dr Clare Howarth from the Department of Psychology at the University of Sheffield also make up members of the research team who worked in collaboration with a team from the University of Manchester led by Professor Stuart Allan and Dr Emmanuel Pinteaux.

Professor Sheila Francis, from the University of Sheffield, said: We noticed quite a few years ago that laboratory mice with severe atherosclerosis (a type of heart disease) exhibited significant behaviour changes. On closer examination, their neurovascular function was altered, leading to the death of brain neurons and increased brain inflammation caused by a protein called interleukin-1.

The study will compare this new model with the commonly used laboratory models of vascular dementia to investigate whether an anti-inflammatory drug against interleukin-1 already used successfully to treat arthritis and in clinical trials for use in stroke patients, could also improve neurovascular function in both cases.

Professor Stuart Allan from the University of Manchester, commented: We are delighted to be involved with this project. We have worked on the role of the protein interleukin-1 in stroke for many years. Our research has led to several clinical trials of an anti-interleukin-1 therapy in stroke, and the possibility that this same treatment might work in vascular dementia is really exciting.

It is hoped the study will lead to anti-interleukin-1 therapies becoming a useful treatment for vascular dementia.

The work forms part of the research of two of the flagship institutes at the University of Sheffield:

Subreena Simrick, Senior Research Adviser at the BHF, said: There is no cure for vascular dementia. Currently, all that doctors can do is prescribe drugs which can slow down its progression.

By funding this research, we hope to take a step towards changing that and bring hope to people affected by this cruel disease.

Unfortunately, our ability to fund important research like this is threatened by the impact of coronavirus on our fundraising. Now, more than ever, we need the support of the public so we can continue to support projects that could transform the lives of those with heart and circulatory diseases.

The University of Sheffield

With almost 29,000 of the brightest students from over 140 countries, learning alongside over 1,200 of the best academics from across the globe, the University of Sheffield is one of the worlds leading universities.

A member of the UKs prestigious Russell Group of leading research-led institutions, Sheffield offers world-class teaching and research excellence across a wide range of disciplines.

Unified by the power of discovery and understanding, staff and students at the university are committed to finding new ways to transform the world we live in.

Sheffield is the only university to feature in The Sunday Times 100 Best Not-For-Profit Organisations to Work For 2018 and for the last eight years has been ranked in the top five UK universities for Student Satisfaction by Times Higher Education.

Sheffield has six Nobel Prize winners among former staff and students and its alumni go on to hold positions of great responsibility and influence all over the world, making significant contributions in their chosen fields.

Global research partners and clients include Boeing, Rolls-Royce, Unilever, AstraZeneca, GlaxoSmithKline, Siemens and Airbus, as well as many UK and overseas government agencies and charitable foundations.

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Arthritis drug to be investigated as possible treatment for vascular dementia - Latest - News - The - University of Sheffield News

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Rheumatoid Arthritis Therapeutics Market: Development Factors and Investment Analysis by Leading Manufacturers – Express Journal

Thursday, October 22nd, 2020

The latest report on the Rheumatoid Arthritis Therapeutics market is an all-inclusive assessment of the business sphere and highlights the vital parameters of the industry including current trends, industry size, market share, present renumeration, periodic deliverables, and profit estimates over the forecast timeline.

New Market Research Report on Rheumatoid Arthritis Therapeutics Market size | Industry Segment by Applications (Prescription and Over-the-Counter (OTC), by Type (Pharmaceuticals and Biopharmaceuticals), By Regional Outlook - Global Industry Analysis, Size, Share, Growth, Opportunity, Latest Trends, and Forecast to 2025.

The report provides a comprehensive evaluation of the Rheumatoid Arthritis Therapeutics market performance during the study period. Insights pertaining to drivers that affect the market dynamics, as well as the growth pattern over the predicted timeframe are documented in the report. It further elaborates the challenges of the market and define the growth prospects in the forthcoming years.

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Unveiling the geographical landscape of the Rheumatoid Arthritis Therapeutics market:

Rheumatoid Arthritis Therapeutics Market bifurcation: USA, Europe, Japan, China, India, South East Asia.

Summary of the regional landscape examined in the report:

An exhaustive review of the Rheumatoid Arthritis Therapeutics market with respect to product type and application scope:

Product scope:

Product types:

Key highlights of the report:

Applications scope:

Application segmentation:

Vital data entailed in the report:

Other takeaways from the Rheumatoid Arthritis Therapeutics market report:

Elucidating details regarding the competitive terrain of the Rheumatoid Arthritis Therapeutics market:

Major players of the industry:

Key parameters included in the report:

Highlights of the Report:

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Rheumatoid Arthritis Therapeutics Market: Development Factors and Investment Analysis by Leading Manufacturers - Express Journal

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The Bidirectional Relationship Between Depression and Rheumatoid Arthritis – AJMC.com Managed Markets Network

Thursday, October 8th, 2020

Although rheumatoid arthritis (RA) only affects 1% of adults in most countries, up to 17% of these patients have a major depressive disorder (MDD). However, not all patients are assessed for their mental well-being even though detecting and managing depression could optimize the care of patients with RA, according to a review published in Rheumatology and Therapy.

Not only is depression 2 times more common in patients with RA than in the general population, but studies have shown there is a bidirectional relationship: the chronic inflammation impairs effective coping behaviors to stress, which results in depression that in turns leads to worse long-term outcomes.

In RA, quality of life (QoL) is significantly decreased because of pain, fatigue, and disability, causing mood change in the form of anxiety and depression, the authors wrote. Observational studies have described a high prevalence of depression and anxiety in RA; [MDDs] are detected in 17% of RA patients, and local and systemic inflammation plays an important role in anxiety and depression.

The authors reviewed previously conducted studies on the impact of depression on disease activity in RA and vice versa.

Patient-reported outcomes like baseline bodily pain and fatigue not only affect QoL and high disease activity but also likely increase depression. There is a relationship between the disease activity score using 28 joints and QoL, and patients with a higher degree of pain had a higher reduction in QoL, the researchers wrote.

A survey by the National Rheumatoid Arthritis Society found that 90% of patients with RA reported fatigue was the main factor causing low mood and depression, with 89% reporting they experienced chronic fatigue and 79% never being assessed to determine their level of fatigue.

RA patients report the effect of the disease on their mental well-being and frequently describe tearfulness, irritability, frustration, anxiety, and depression, the authors explained.

Depression is the most common mental health disorder associated with RA, and presents with low mood, low self-esteem, fatigue, lethargy, and more. In addition, MDD can present with more aggressive symptoms of depression and can potentially be fatal if left untreated since it also presents with suicidal ideation.

Studies have shown that depression reduces medication adherence and that patients with depression may have reduced physical exercise and social interaction because their coping responses to pain, fatigue, and disability are impaired.

RA patients diagnosed with depression have reduced rates of clinically significant RA remission, increased pain, worse function and quality of life, and increased mortality, the authors wrote. PROs hence become an essential factor for optimising the holistic care of RA.

The researchers noted that studies have found that biologic disease-modifying antirheumatic drugs (DMARDs) and conventional synthetic DMARDs can improve depressive symptoms in patients with RA. However, when depression is present in patients with RA before they start on biologic DMARDs, it can reduce treatment response.

Further observational studies for early detection of anxiety and depression in RA patients using web-based questionnaires would be of help for both patients and clinicians, the authors concluded.

Reference

Lwin MN, Serhal L, Holroyd C, Edwards CJ. Rheumatoid arthritis: the impact of mental health on disease: a narrative review. Rheumatol Ther. 2020;7(3):457-471. doi:10.1007/s40744-020-00217-4

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24-hour Activity and Sleep Profiles for Adults Living with Arthritis: Habits Matter – DocWire News

Thursday, October 8th, 2020

Objectives:Identify 24-hour activity-sleep profiles in adults with arthritis and explore factors associated with profile membership.

Methods:Cross-sectional cohort, using baseline data from two randomized trials studying activity counselling for people with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or knee osteoarthritis (OA). Participants wore activity monitors for 1-week and completed surveys for demographics, mood (Patient Health Questionnaire-9) and sitting and walking habits (Self-Reported Habit Index). 1440 minutes / day stratified into minutes off-body, sleeping, resting, non-ambulatory, and intermittent or purposeful ambulation. Latent class analysis determined cluster numbers; baseline-category multinomial logit regression identified factors associated with cluster membership.

Results:172 people (RA: 51%, OA:30%, SLE: 19%). Clusters: High Sitters: 6.9 hours sleep, 1.6 hours rest, 13.2 hours non-ambulatory, 1.6 hours intermittent and 0.3 hours purposeful walking. Low Sleepers: 6.5 hours sleep, 1.2 hours rest, 12.2 hours non-ambulatory, 3.3 hours intermittent and 0.6 hours purposeful walking. High Sleepers: 8.4 hours sleep, 1.9 hours rest, 10.4 hours non-ambulatory, 2.5 hours intermittent and 0.3 hours purposeful walking. Balanced Activity: 7.4 hours sleep, 1.5 hours sleep, 9.4 hours non-ambulatory, 4.4 hours intermittent and 0.8 hours purposeful walking. Younger age [OR: 0.95 (95% CI: 0.91-0.99)], weaker occupational sitting habit [OR: 0.55 (95% CI: 0.41-0.76)] and stronger walking outside habit [OR: 1.43 (95% CI: (1.06-1.91)] were each associated with Balanced Activity relative to High Sitters.

Conclusions:Meaningful subgroups were identified based on 24-hour activity-sleep patterns. Suggesting tailoring interventions based on 24-hour activity-sleep profiles may be indicated, particularly in adults with stronger habitual sitting or weaker walking behaviors.

Keywords:24-hour activity and sleep profiles; accelerometry; adults; arthritis; habit strength; latent class analysis.

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24-hour Activity and Sleep Profiles for Adults Living with Arthritis: Habits Matter - DocWire News

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5 easy hand exercises for people with arthritis – Starts at 60

Thursday, October 8th, 2020

Arthritis is a common condition that causes pain and stiffness in and around the joints. In fact, there are over 100 types of arthritis that affect the hand and wrist joints, with osteoarthritis, rheumatoid arthritis, psoriatic arthritis and gout being the main offenders, exercise physiotherapist Kusal Goonewardena tells Starts at 60.

[This can] result in decreased mobility, reduced strength and a lack of function especially grip strength and inability to use fingers effectively, he explains.

The good news is exercise can help certain hand exercises can help to reduce pain, stiffness and swelling, and improve joint flexibility. So what are some good exercises that can help ease the pain? Below, with the help of Kusal, weve listed five easy hand exercises that you can do from the comfort of your own home. Just be sure to check with your doctor or physiotherapist before starting a new routine.

Place your palms together in a prayer position. Then keep your palms pressing together as you move your hands above your head. Hold for 30 seconds before moving your hands down. Kusal says to repeat this step two more times.

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5 easy hand exercises for people with arthritis - Starts at 60

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Diagnostic Performances of Depression and Anxiety Screening Measures in Rheumatoid Arthritis – Rheumatology Advisor

Thursday, October 8th, 2020

In patients with rheumatoid arthritis (RA), the diagnostic performance of screening instruments for depression was good, while screening instruments for anxiety were more variable, according to study results published in Arthritis Care & Research.

Previous studies reported higher rates of depression and anxiety in patients with RA, compared with the general population. As there are limited data on the diagnostic performances of available tools for assessing depression and anxiety in RA, the goal of the current study was to investigate the validity, reliability and optimal cut point of multiple screening instruments for mental disorders for patients with RA.

The study cohort included adults with RA, recruited through the Arthritis Centre clinic in Winnipeg, Manitoba, and through community clinics between November 2014 and July 2016.

Each participant completed the Patient Health Questionnaire (PHQ-2 or PHQ-9), the Patient Reported Outcomes Measurement Information System depression short form 8a and anxiety short form 8a, the Hospital Anxiety and Depression Scale anxiety score (HADS-A) and depression score (HADS-D), the Overall Anxiety Severity and Impairment Scale, the Generalized Anxiety Disorder 2-and 7-item scales, and the Kessler-6 scale.

Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Axis I Disorders (SCID-1) research version was used as the criterion standard to confirm clinical depression and anxiety disorders in the study participants.

The study included 150 participants (127 women, mean age 59.8 years) who completed the SCID-1 shortly after enrollment. Using the criterion standard of the SCID-1 to confirm clinical diagnosis, the prevalence of current depression was 11.3%, prevalence of generalized anxiety disorder was 7.3%, and prevalence of any anxiety disorder was 19.3%.

For depression, Kessler-6 scale and the HADS-D (cut point 11) had the lowest sensitivity (35% for both) and the highest specificity (96% and 94%, respectively). Sensitivity was highest for the PHQ-2 (88%) and PHQ-9 (87%), with specificity of 84% and 77%, respectively.

For anxiety, sensitivity was highest for the HADS-A with a cut point 11 points (91%), and lowest for HADS-A with a cut point 8 points. While the specificity was lowest for the former (45%), it was the highest for the latter (91%).

All depression and anxiety instruments had acceptable internal consistency and reliability. For depression instruments, internal consistency ranged between 84% to 97% and the test-retest reliability interclass correlation coefficient ranged between 84% and 88%. For anxiety instruments, internal consistency ranged between 69% to 93% and the test-retest reliability interclass correlation coefficient ranged between 69% and 83%.

Based on the area under the curve, the diagnostic performances of all the depression and anxiety instruments were remarkably similar. While the diagnostic performance for depression was generally good, it was not excellent (area under the curve <0.90). The diagnostic instruments for anxiety were less accurate than those for depression; performance was better for identifying generalized anxiety disorder than for any anxiety disorder.

The study had several limitations, among them are the inclusion of patients from the same region indicating that the findings may not apply to other settings, limited access to biologic therapies and mental health support, potential participant bias, and potential limitations due to administration of multiple instruments at the same time.

[T]he optimal choice of screening instrument, and optimal cut point, may vary depending on the situation and purpose of administration. Regardless, incorporation of screening tools for depression and anxiety into clinical practice may improve outcomes for patients with RA, wrote the researchers.

Hitchon CA, Zhang L, Peschken CA, et al. Validity and reliability of screening measures for depression and anxiety disorders in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2020;72(8):1130-1139.

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Five common signs of painful rheumatoid arthritis that you may be missing – Express

Thursday, October 8th, 2020

It can leave the joints feeling sore and inflamed, and could even damage the surrounding cartilage or tendons.

On some occasions, the symptoms can extend to other parts of the body, including the lungs or heart.

Around 400,000 people in the UK have been diagnosed with rheumatoid arthritis.

One of the key warning signs of the condition is developing a high fever.

READ MORE: Rheumatoid arthritis - vitamin to reduce risk

"Rheumatoid arthritis mainly attacks the joints, usually many joints at once," said the US Centers for Disease Control Prevention.

"With rheumatoid arthritis, there are times when symptoms get worse, known as flares, and times when symptoms get better, known as remission.

"Signs and symptoms of rheumatoid arthritis include: Pain or aching in more than one joint, stiffness in more than one joint, weight loss, fever, fatigue, weakness.

"Signs and symptoms of rheumatoid arthritis are not specific and can look like signs and symptoms of other inflammatory joint diseases."

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Efficacy and Safety of JAK Inhibitors for the Treatment of Rheumatoid Arthritis – Rheumatology Advisor

Thursday, October 8th, 2020

Novel selective oral Janus activated kinase (JAK) inhibitors, tofacitinib, baricitinib, and upadicitinib, improve disease control and quality of life of patients with rheumatoid arthritis (RA), but there are also several safety concerns, including potential increased risk for infection and venous thromboembolism, according to study results published in Mayo Clinic Proceedings.

As a family of intracellular tyrosine kinases, JAKs are involved in the pathogenesis of various inflammatory and autoimmune disorders. There are 4 members in the JAK family: JAK1, JAK2, JAK3, and receptor tyrosine kinase 2 (TYK2). Currently, there are 3 FDA-approved oral JAK inhibitors for the treatment of RA: tofacitinib, which inhibits JAK1/3 with less inhibition of JAK2 and TYK2; baricitinib, an inhibitor of JAK 1/2 with moderate activity against TYK2; and upadacitinib, which is a JAK1-selective inhibitor.

The goal of the current systematic review and meta-analysis was to compare the safety and efficacy of these 3 drugs for the treatment of RA.

The researchers performed a systematic search of MEDLINE, EMBASE, and the Cochrane Library through December 11, 2019, to identify randomized controlled trials that included adult patients with active RA, treated with tofacitinib, baricitinib, or upadicitinib. All included studies determined efficacy and safety outcomes.

Of 116 identified clinical trials, 20 studies (8982 unique patients) with a low risk of bias were included in the analysis: 12 tofacitinib trials, 5 baricitinib studies, and 3 designed to test upadacitinib.

All JAK inhibitors were found to be effective in reducing RA disease activity, and the overall pooled analysis showed that the response rate according to American College of Rheumatology 20% (ACR) criteria was 2-fold higher than placebo (relative risk [RR], 2.03; 95% CI, 1.87-2.20; P <.001), and all treatments were associated with significant decreases in Health Assessment Questionnaire Disability Index (HAQ-DI) (mean differences, -0.31; 95 CI, -0.34 to -0.28; P <.001).

Tofacitinib at a dose of 10 mg, twice daily, was associated with the highest response rate according to ACR20 (RR, 2.48; 95% CI, 1.97-3.14; P <.001) and the most statistically significant improvement in HAQ-DI score (mean difference, -0.38; 95% CI, -0.44 to -0.31; P <.001).

The overall incidence of adverse events was higher among patients treated with JAK inhibitors (RR, 1.09; 95% CI, 1.05-1.13; P <.001), but the frequency of serious adverse events in any of the treatment groups was not significantly different compared with placebo.

Tofacitinib given at a dose of 10 mg, twice daily, was associated with the highest risk for infection (RR, 2.75; 95% CI, 1.72-4.41), followed by upadacitinib, 15 mg, daily (RR, 1.35; 95% CI, 1.14-1.60) and baricitinib, 4 mg, daily (RR, 1.28; 95% CI, 1.12-1.45). On the other hand, treatments with tofacitinib 5 mg, twice daily, baricitinib at a daily dose of 2 mg, or upadacitinib 30 mg daily, were not associated with an increased risk for infection.

Data on venous thromboembolism was only available from upadacitinib trials, indicating the JAK inhibitor was not associated with a significant increase in risk for venous thromboembolic disease.

The study had several limitations, including the small number of trials with baricitinib and upadacitinib, significant heterogeneity in study design, follow-up duration and treatment duration. Furthermore, in some trials patients in the placebo group switched to active treatment during the follow-up.

Longer-term follow-up and additional trials with head-to-head comparison of tofacitinib, baricitinib, and upadacitinib, as well as additional information from ongoing trials of these and other JAK inhibitors, including peficitinib and filgotinib, will be important to further determine both efficacy and the safety profile of these agents in the management of RA, wrote the researchers.

Wang F, Sun L, Wang S, et al. Efficacy and safety of tofacitinib, baricitinib, and upadacitinib for rheumatoid arthritis: a systematic review and meta-analysis. Mayo Clin Proc. 2020;95(7):1404-1419. doi:10.1016/j.mayocp.2020.01.039

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Efficacy and Safety of JAK Inhibitors for the Treatment of Rheumatoid Arthritis - Rheumatology Advisor

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Active Wheelchair Market | High Prevalence of Arthritis to Contribute toward Spiraling Demand for Active Wheelchairs – BioSpace

Thursday, October 8th, 2020

Active wheelchairs resemble most of the sports wheelchairs available in the market and are easy to maneuver. These wheelchairs are utilized on a daily basis and are usually more of a premium product than the usual, standard wheelchairs. It also comprises wheelchairs for people who want to remain active in life. Most of the sports wheelchairs are the active wheelchairs. Easily navigable, these wheelchairs come in two different forms, which are rigid or folding. These chairs can be easily adjusted to cater to the need of the users and their lifestyle, which is estimated to support growth of the global active wheelchair market over the period of forecast, from 2019 to 2029.

Rising in the number of disabled and geriatric population across the globe is likely to accentuate the demand for active wheelchairs in the near future. In addition, constant efforts to better the efficiency of these wheelchairs, favorable initiatives by the government, and rise in the incidences of chronic diseases is likely to trigger growth of the global active wheelchair market in the years to come.

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Type, indication, and region are the three key parameters based on which the global active wheelchair market has been divided. The objective of such segmentation is to offer a clearer, 360-degree view of the market.

Global Active Wheelchair Market: Notable Developments

The global active wheelchair market has witnessed significant developments in the recent years. One of such developments pertaining to the market is mentioned below:

Some of the key players in the global active wheelchair market comprise the below-mentioned:

Global Active Wheelchair Market: Key Trends

The following drivers, restraints, and opportunities characterize global active wheelchair market over the assessment period, from 2019 to 2029.

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In comparison with a traditional wheelchair, this active one is considered an upscale product. Active wheelchairs are considered a blessing for people who prefer to remain active, which is why it has gained tremendous popularity in the last few years.

According to the findings of Centers for Disease Control and Prevention (CDC), nearly 54.4 million adults in the US were suffering from arthritis in the period that spanned from 2013 to 2015. In addition, it is also forecasted that nearly 36.4 million people with arthritis is estimated to have limited activities by 2040. With such increased prevalence of disabilities, the global active wheelchair market is likely to observe considerable growth over the period of assessment, from 2019 to 2019.

In addition, rise in the disposable income of the people together with increasing approvals of product is forecasted to work in favor of the global active wheelchair market in the years to come. There are many government policies encouraging adoption of these wheelchairs, which is likely to pave way for accelerated adoption of active wheelchairs in the years to come.

Global Active Wheelchair Market: Geographical Analysis

Expanding base of geriatric population together with rising expenditure on healthcare is likely to place Europe at the forefront of the global active wheelchair market. The dominance of Europe over the market is likely to continue throughout the period of forecast. Asia Pacific is estimated to come up as a rapidly growing region with rising disposable income and inclination toward spending on premium medical devices.

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The global active wheelchair market is segmented as:

Type

Indication

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Active Wheelchair Market | High Prevalence of Arthritis to Contribute toward Spiraling Demand for Active Wheelchairs - BioSpace

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Edmonton Oilers: Oscar Klefbom Dealing With Arthritis – Oilers Nation

Thursday, October 8th, 2020

Oscar Klefbom has played with shoulder pain for a few years. And hes lived with it daily. His shoulder discomfort has even made sleeping uncomfortable at times during the hockey season.

Two different sources confirmed Klefboms shoulder ailment has been an issue for years.

Im told he is dealing with chronic arthritis in his shoulder, and surgery isnt an easy fix. There is no guarantee it will solve the problem, and the major concern for Klefbom is if he has surgery and nothing improves, it might make it worse. A medical person explained that one reason to have surgery would be to debride the joint and possibly take a part of the acromion (a bony process on the scapula) to give him better function in his shoulder.

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Today, Oilers GM Ken Holland addressed Klefboms status.

I dont think its that simple, said Holland responding to why didnt Klefbom have surgery once the Oilers were eliminated.

If he needs it, why doesnt he get surgery and why wait two months? Then youve lost two months. If it was that easy, he would make those decisions but its not that easy. He played with some pain. In February we shut him down for I think nine games. He went to see a shoulder specialist, and again its not cut and dry.

Its not as simple as you do have surgery or you dont have surgery. I think Klef needs to make a decision based upon the information that hes given from his body and the doctors hes seen a couple of shoulder specialists and see how he wants to proceed.

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In past years the season has ended and theres been a long offseason for it (his shoulder) to get better and he comes back and he plays. But as he goes forward each year the body is another year older and beat up a little more. He has to decide how he wants to proceed and again, from the clubs perspective, would you like to have an answer? Yeah. But, I always think Ive got to respect that this is an important player on the team, but hes also a person who has to make a decision that is going to be very important to him going forward in his life and I have to respect that.

Hollands response about it being an issue that isnt easily fixed by surgery matches with my sources confirming Klefbom is dealing with arthritis.

Klefbom has tried different treatments to fix it, and often the pain subsides, but then it reappears during the wear and tear of an NHL season.

Holland also mentioned it is likely Klefbom wont be ready to start the season, and could possibly be sidelined for the entire year.

Will surgery help? They dont know and that is why Klefbom is not rushing into a decision. It could have a huge impact on how much longer he is able to play.

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Edmonton Oilers: Oscar Klefbom Dealing With Arthritis - Oilers Nation

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How to Prevent Arthritis and Stop Arthritis From Progressing – LIVESTRONG.COM

Thursday, October 8th, 2020

Low-impact exercise like biking is a great way to keep your joints healthy.

Image Credit: adamkaz/E+/GettyImages

More than 54 million Americans have arthritis, according to the Centers for Disease Control and Prevention (CDC). That's more than 1 in 5 people. While there are some known risk factors that can lead to this common condition, many such as a person's genes are outside of our control.

But not all of them. "Some [forms of arthritis] are preventable, others are modifiable," says Daniel Wallace, MD, rheumatologist and spokesperson for Voltaren.

There are also many tactics that can help improve your overall joint health. That's important, since healthy joints allow you to move with ease and aid in protecting your bones, per the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMSD).

Arthritis refers to any type of pain or swelling in the joints, and there are more than 100 varieties, per Stuart D. Kaplan, MD, chief of rheumatology at Mount Sinai South Nassau in Oceanside, New York.

The most common type is osteoarthritis (OA), also known as degenerative arthritis, according to the Arthritis Foundation. As protective cartilage wears away, bones touch at joints sometimes, youll hear OA referred to as wear-and-tear arthritis.

The other most commonly diagnosed variety is rheumatoid arthritis (RA), an inflammatory type. Its an auto-immune disease, which means the body is fighting itself. It can attack the joints, which become red-hot and swollen, Dr. Kaplan says.

Some risk factors apply to only one of these two common forms.

Here are a few science-backed tactics that'll help reduce your arthritis risk factors, along with promoting good joint health.

1. Maintain a Healthy Weight

Carrying around extra pounds puts extra pressure on your knees, Dr. Tariq says.

Image Credit: Rostislav_Sedlacek/iStock/GettyImages

"Obesity is a big risk factor for osteoarthritis, especially in the weight-bearing areas, like the knees and lower back," Saad Tariq, MD, a rheumatologist with Ortho Illinois, tells LIVESTRONG.com.

The pressure on your knees adds up to 1.5 times your body weight, per Harvard Health Publishing and that's on level ground; it's even higher on inclines (like steps) and can be up to five times your body weight when you squat to, say, tie your shoe.

That's why people with obesity are more likely to develop OA in these areas, per the CDC. And since excess fat leads to inflammation-causing proteins circulating in your body, obesity ups your risk of developing OA in your hands, too, per the Arthritis Foundation.

"Trying to modify the diet, and trying to exercise to lose weight can definitely prevent end-stage bone-on-bone arthritis [osteoarthritis] and chronic pain," Dr. Tariq says. (More on diet and exercise in a minute.)

2. Consider Following a Mediterranean Diet

There's no diet that can prevent arthritis (nor, for that matter, is there a diet that can cure this condition). That said, a healthy diet will help you manage your weight.

And there's one diet that might be particularly helpful to follow: "The Mediterranean diet has been shown consistently to be helpful for reducing inflammation," Dr. Tariq says. That's key, since both RA and OA involve inflammation in the joints.

Following the Mediterranean diet means eating lots of vegetables, fruits, fish, whole grains and healthy fats, while limiting red meat, according to the Mayo Clinic. It's linked to weight loss and a lower BMI, per a March 2019 review published in Nutrients.

The Mediterranean diet was helpful for managing symptoms in people with RA, but there wasn't enough evidence to support that the diet prevented RA in a December 2017 systematic review published in Rheumatology International.

But this diet may help to prevent RA in former and current smokers, according to a September 2020 study published in Arthritis & Rheumatology. And, while acknowledging some limitations in studies, an August 2018 review published in the journal Nutrients noted that OA prevalence is lower in people with high levels of adherence to the Mediterranean diet.

An apple a day may do more than keep the doctor away.

Image Credit: DjelicS/E+/GettyImages

Arthritis is an inflammatory disease the symptoms of this condition spring from inflammation in the joints.

Consuming a high-fiber diet can decrease inflammation and improve osteoarthritis, Dr. Tariq says. Consuming higher fiber levels was associated with a lower risk of developing symptomatic OA in the knee, per a May 2017 study in Annals of the Rheumatic Diseases.

Fruits, vegetables, whole grains and legumes are all good sources of fiber, per the Mayo Clinic.

It may also be helpful to limit or avoid inflammatory foods that can make symptoms worse. These include refined carbohydrates (think: white bread and pastries), fried foods, sugary beverages like soda, red and processed meats and margarine, according to Harvard Health Publishing.

It's hard to even tally up the reasons to quit smoking because this habit is so negative to nearly every facet of your health.

Smoking is a risk factor for developing RA, per the CDC.

It's a preventable risk factor for osteoarthritis, too, Dr. Tariq says, because smoking can lead to bone deterioration.

Gum disease and RA are connected.

Image Credit: Natalia Bodrova/iStock/GettyImages

Practicing good dental hygiene brushing several times a day, and flossing too can help prevent gingivitis (gum disease), which may lead to RA, Dr. Tariq says.

Research certainly shows a link between gingivitis and RA. It's possible that inflammation associated with the teeth and mouth may "play a role in the development of rheumatoid arthritis," per a May 2013 review in Current Opinion Rheumatology. And more recently, a December 2016 study in Science Translation Medicine found that the bacteria involved in gingivitis also triggers the inflammatory response found in people with RA.

More research is needed here, though, as the Cleveland Clinic notes, to fully understand if one condition triggers the other one. Still, since gum disease isn't a desirable outcome either, it's a good idea to take care of your pearly whites.

Along with helping you to maintain a healthy weight, exercise is also good for keeping muscles and joints healthy, Dr. Kaplan says.

"Any kind of exercise that doesn't strain muscles is good," he says, and cautions people to start gradually especially if it's been a while since you've been active and build up to a higher tolerance and endurance.

The stronger your muscles, the better they're able to protect your joints and potentially prevent osteoarthritis, per University of Iowa Health Care. Plus, physical activity helps prevent stiffness in your joints, according to the University of Rochester Medical Center.

"In general, I recommend range-of-motion exercises things that keep the joints moving, like walking, swimming, bicycling," Dr. Kaplan says.

7. Prevent Joint Injuries

Working to strengthen your knees can help reduce your risk of OA.

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OA is mainly thought of as a disease that accompanies age with a lot of use of the joint, cartilage wears down, leading to friction and the dreaded bone-on-bone contact.

But OA can also be the result of an injury caused by physical activity or accidents, per the Mayo Clinic.

Of course, you can't retreat to a bubble to avoid injuries and accidents. But there are reasonable and prudent tactics you can take to protect your joints:

Do Knee Exercises (Particularly if You Do Activities With a Risk of ACL Tears)

People who injure their anterior cruciate ligament (ACL) up their risk of having knee OA later in life by three to six times, per the Osteoarthritis Action Alliance (OAAA). But by doing neuromuscular training exercises proposed by the OAAA which include balance training, plyometric jumping and core strengthening you can cut the risk of an ACL or other knee injury by 80 percent.

That's worth considering if you play a sport such as football or soccer where ACL injuries are common.

We've all heard it: Lift with your legs, not your back. But the advice is solid to protect your back, Dr. Tariq says.

To lift objects correctly, per the American Chiropractic Association, follow these best practices:

Listen to your body, Dr. Tariq recommends if something hurts, avoid doing it.

If your work involves lifting heavy objects, take particular care, Dr. Tariq says. Try to regularly do back exercises and strengthen those muscles, he says. Exercising the parts of the body that are frequently in use will prevent stiffness and pain.

Avoid the prolonged sitting (first in front of the computer, then later on the couch) that can take over a person's day, Dr. Tariq says. Why? Joint injuries are more common if you hold a position for a while, per the American Chiropractic Association.

"Every hour, try to get up and stretch and change your posture," Dr. Tariq recommends. Doing so will reduce pain and stiffness.

Take a look at your posture when you're sitting for long periods at your desk or during a long drive, he says. Having a neutral posture helps reduce aches and prevent pain.

See the original post:
How to Prevent Arthritis and Stop Arthritis From Progressing - LIVESTRONG.COM

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