StemCell Therapy

An international team of scientists has developed artificial neurons on silicon chips that behave just like neurons in the body. The first-of-its-kind achievement could lead to the development of medical devices for treating chronic diseases, such as heart failure, Alzheimers disease, or other neurodegenerative disorders. Critically, the artificial neurons not only behave just like biological neurons, but require just one-billionth the power of a microprocessor, making them ideally suited for use in medical implants and other bio-electronic devices.

Until now neurons have been like black boxes, but we have managed to open the black box and peer inside, stated research lead Alain Nogaret, PhD, professor from the University of Bath department of physics. Our work is paradigm-changing because it provides a robust method to reproduce the electrical properties of real neurons in minute detail. But its wider than that because our neurons only need 140 nanoWatts of power. Thats a billionth of the power requirement of a microprocessor, which other attempts to make synthetic neurons have used. This makes the neurons well suited for bio-electronic implants to treat chronic diseases.

The researchers, led by the University of Bath team, and including collaborators at the Universities of Bristol, Zurich, and Auckland, describe the artificial neurons in a study published in Nature Communications, titled, Optimal solid-state neurons.

Designing artificial neurons that respond to electrical signals from the nervous system in the same way that real neurons would has been a major goal in medicine for decades, as it would open up the possibility of curing conditions in which neurons dont work properly, have had their processes severed, as in spinal cord injury, or have died. Artificial neurons could repair diseased biocircuits by replicating their healthy function and responding adequately to biological feedback to restore body functions.

However, developing artificial neurons comes with immense challenges associated with the complex biology and hard-to-predict neuronal responses. The difficulty of measuring microscopic parameters that control the dynamics of ionic currents and the nonlinearity of ionic conductances has hampered so far theoretical efforts to build quantitative computational models and subsequently neuromorphic devices replicating the exact response of a biological neuron, the authors wrote.

Silicon neurons, synapses, and brain-inspired networks have all been proposed, but these designs werent meant to recapitulate the behavior of biological cells in detail, rather, they were intended to help identify the organizing principles of biology that could be applied to practical devices. The increasing focus on implantable bioelectronics to treat chronic disease is however changing this paradigm and is instilling new urgency in the need for low-power analog solid-state devices that accurately mimic biocircuits.

For their research to design artificial neurons, the researchers successfully modeled and derived equations to explain how neurons respond to electrical stimuli from other nerves. This is a hugely complicated task, as responses are non-linear, such that a doubling of signal strength may not elicit a reaction doubling. The response may be more, or less than double.

The team then designed silicon chips that accurately modeled biological ion channels, and confirmed that their silicon neurons precisely mimicked real, living neurons responding to a range of stimulations. To demonstrate their models the researchers accurately replicated the complete dynamics of hippocampal neurons and respiratory neurons from rats, under a wide range of stimuli. we built six-channel silicon devicesthat faithfully model CA1 hippocampal and respiratory neurons, they stated. The completed models predict the membrane voltage of biological neurons in excellent agreement (9497%) with the membrane voltage oscillations observed in response to 60 different current protocols.

The potential applications are manifold, the researchers believe. For example, were developing smart pacemakers that wont just stimulate the heart to pump at a steady rate but use these neurons to respond in real-time to demands placed on the heartwhich is what happens naturally in a healthy heart, Nogaret stated.

In heart failure for example, neurons in the base of the brain do not respond properly to nervous system feedback, they in turn do not send the right signals to the heart, which then does not pump as hard as it should. For example, the respiratory neurons which we have modeled couple the respiratory and cardiac rhythms and are responsible for respiratory sinus arrhythmia, the authors commented. Loss of this coupling through age or disease is a prognosis for sleep apnoea and heart failure. Therefore, a device that adapts to biofeedback in the same way as respiratory neurons may offer a much needed therapy for heart failure. Our accurate description of the neurobiology within a model derived from silicon physics answers this need.

Other possible applications could be in the treatment of conditions like Alzheimers and neuronal degenerative diseases more generally, Nogaret suggested. Our approach combines several breakthroughs. We can very accurately estimate the precise parameters that control any neurons behavior with high certainty. We have created physical models of the hardware and demonstrated its ability to successfully mimic the behavior of real living neurons. Our third breakthrough is the versatility of our model which allows for the inclusion of different types and functions of a range of complex mammalian neurons.

Study co-author Giacomo Indiveri, PhD, from the University of Zurich and ETF Zurich, commented, This work opens new horizons for neuromorphic chip design thanks to its unique approach to identifying crucial analog circuit parameters.

Added co-author, Julian Paton, PhD, a physiologist at the University of Auckland and the University of Bristol, said, Replicating the response of respiratory neurons in bioelectronics that can be miniaturized and implanted is very exciting and opens up enormous opportunities for smarter medical devices that drive towards personalized medicine approaches to a range of diseases and disabilities.

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Artificial Neurons on a Chip Developed to Treat Chronic Diseases - Genetic Engineering & Biotechnology News

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