TORONTO--(BUSINESS WIRE)--Antibe Therapeutics Inc. ("Antibe" or the Company) (TSXV: ATE, OTCQB: ATBPF), a leader in developing safer, non-addictive therapeutics for pain and inflammation, is pleased to announce that the last patient has been enrolled and is on treatment in the Phase 2B dose-ranging, efficacy study of Antibes lead drug, ATB-346. The study is evaluating the effectiveness of ATB-346 in reducing osteoarthritis (OA) pain compared to placebo in 360 patients.
The final patients will be on treatment for two weeks, followed by a two-week monitoring period and analysis of the primary endpoint data. The primary endpoint in the study is the change in OA knee pain of ATB-346 versus placebo as measured by the WOMAC subscale pain score, considered the gold standard in pain assessment for arthritis trials. Patients have been randomized to placebo or one of three doses of ATB-346 administered once daily: 150 mg, 200 mg or 250 mg.
The Company anticipates the release of top-line results within six weeks.
About ATB-346
ATB-346 is a hydrogen sulfide-releasing derivative of naproxen. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used therapy for osteoarthritis, but their use is associated with a high incidence of gastrointestinal ulceration and bleeding. NSAIDs are also widely used in conditions such as rheumatoid arthritis, ankylosing spondylitis, gout, and general pain reduction, with a similarly high rate of gastrointestinal ulceration and bleeding. It is well-accepted that patients with these conditions would benefit greatly from an effective, non-addictive, GI-sparing anti-inflammatory/analgesic agent such as ATB-346.
About Antibe Therapeutics Inc.
Antibe develops safer, non-addictive medicines for pain and inflammation. Antibes technology involves linking a hydrogen sulfide-releasing molecule to an existing drug to produce an improved medicine. Antibes lead drug, ATB-346, targets the global need for a safer, non-addictive drug for chronic pain and inflammation. ATB-352, the second drug in Antibes pipeline, targets the urgent global need for a non-addictive analgesic for treating post-surgical pain, while ATB-340 is a GI-safe derivative of aspirin. Citagenix Inc., an Antibe subsidiary, is a market leader and worldwide distributor of regenerative medicine products for the dental marketplace. http://www.antibethera.com.
Forward Looking Information
This news release includes certain forward-looking statements, which may include, but are not limited to, the proposed licensing and development of drugs and medical devices. Any statements contained herein that are not statements of historical facts may be deemed to be forward-looking, including those identified by the expressions "will", "anticipate", "believe", "plan", "estimate", "expect", "intend", "propose" and similar wording. Forward-looking statements involve known and unknown risks and uncertainties that could cause actual results, performance, or achievements to differ materially from those expressed or implied in this news release. Factors that could cause actual results to differ materially from those anticipated in this news release include, but are not limited to, the Companys inability to secure additional financing and licensing arrangements on reasonable terms, or at all, its inability to execute its business strategy and successfully compete in the market, and risks associated with drug and medical device development generally. Antibe Therapeutics assumes no obligation to update the forward-looking statements or to update the reasons why actual results could differ from those reflected in the forward-looking statements except as required by applicable law.
- 15 Home Essentials That Make Life Easier If You Have Arthritis - HuffPost - September 21st, 2024
- Gout, a painful form of arthritis, is on the rise. Avoiding red meat and alcohol can help. - Yahoo Life - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pain - MedicineNet - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - U.S. News & World Report - September 21st, 2024
- Arthritis can flare up in colder weather: Tips to easing the pan - Medical Xpress - September 21st, 2024
- See how Waymo is bringing Arthritis Foundation of Arizona families to the ballpark - ABC15 Arizona in Phoenix - September 21st, 2024
- Prevalence of Loneliness in Inflammatory Arthritis and its Association with Disease Activity - Physician's Weekly - September 21st, 2024
- Psoriatic Arthritis and Gluten: Whats the Link? - Health Central - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Southernminn.com - September 21st, 2024
- 6 Knee Injuries That Can Cause Arthritis - Health News Hub - September 21st, 2024
- The Best Rheumatoid Arthritis Self-Care Tips To Soothe Painful Joints and Improve Mobility - Yahoo Life - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - El Paso Inc. - September 21st, 2024
- Shifting kneecap in kids? Early ligament repair can prevent arthritis in young Age: Experts - The Times of India - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Shelbynews - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Citizentribune - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - News-Daily.com - September 21st, 2024
- Casavant: Access to virtual care at risk for millions of arthritis patients - Daily Independent - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - Avery Journal Times - September 21st, 2024
- Arthritis Can Flare Up in Colder Weather: Tips to Easing the Pan - The Elkhart Truth - September 21st, 2024
- What To Eat (And Skip) on a Rheumatoid Arthritis Diet To Reduce Painful Inflammation - Woman's World - September 21st, 2024
- Tiny knee bone linked to arthritis may have helped humans walk upright, scientists suggest - Sky News - September 13th, 2024
- Medical Marijuana Helps People With Arthritis And Other Rheumatic Conditions Reduce Use Of Opioids And Other Medications, Study Shows - Marijuana... - September 13th, 2024
- My 'stomach bug' turned out to be an agonising pain condition that left me wheelchair bound within four years - Daily Mail - September 13th, 2024
- Distinct mucosal endotypes as initiators and drivers of rheumatoid arthritis - Nature.com - September 13th, 2024
- Early Use of Steroids Linked to Prolonged Treatment in RA - Medscape - September 13th, 2024
- How rheumatoid arthritis and Down syndrome are helping researchers find treatments for Alzheimer's - Colorado Public Radio - September 13th, 2024
- Is It Bad to Drink Coffee if You Have Rheumatoid Arthritis? - Health Central - September 13th, 2024
- Harnessing Patient Insights: The Role of PROs in Managing Psoriasis and Psoriatic Arthritis - MD Magazine - September 13th, 2024
- Spotlight On Maryland-The Arthritis Foundation - Audacy - September 13th, 2024
- Gum disease and arthritis: How bacteria in your mouth could be hurting your joints - Hindustan Times - September 13th, 2024
- An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis - Nature.com - September 13th, 2024
- Sky's Angel Reese to have wrist surgery Tuesday, be in cast for six weeks - USA TODAY - September 13th, 2024
- A message from AdventHealth: Swing into action to fight Arthritis - Johnson County Post - September 13th, 2024
- Bio-Thera Solutions and Biogen Publish Phase 3 Clinical Trial Data for TOFIDENCE (BAT1806/BIIB800), an approved Biosimilar referencing tocilizumab in... - September 13th, 2024
- Failed Remission in Early RA No Better With Added Etanercept - Medscape - August 25th, 2024
- Trapeziectomy and Mini TightRope Suspensionplasty for First Carpometacarpal Joint Arthritis - Cureus - August 25th, 2024
- What is early arthritis? UAB experts weigh in - University of Alabama at Birmingham - August 25th, 2024
- Evaluating and Adjusting Rheumatoid Arthritis Treatment: Adhering to ACR Guidelines for csDMARDs and Advanced Therapies - MD Magazine - August 25th, 2024
- Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation - Nature.com - August 25th, 2024
- The association between the aggregate index of systemic inflammation and risk of rheumatoid arthritis: retrospective analysis of NHANES 19992018 -... - August 25th, 2024
- High Prevalence of Tendon Issues in Hand Osteoarthritis - Medscape - August 25th, 2024
- The point of knee shots - Harvard Health - August 25th, 2024
- Exploring the Discrepancy Between Patient Perception and Disease Activity Assessments - MD Magazine - August 25th, 2024
- Do you have knee pain from osteoarthritis? You might not need surgery. Here's what to try instead - ABC News - August 25th, 2024
- Blood test provides early alert to knee arthritis - Cleveland Jewish News - August 7th, 2024
- Lifestyle tips for youth's bone health: Avoid these habits to prevent arthritis - Hindustan Times - January 25th, 2024
- Arthritis | Johns Hopkins Medicine - January 9th, 2024
- What Is Arthritis? | Arthritis Foundation - May 17th, 2023
- Procedure to Surgery for Arthritis Is Recommended After First Failed Non-Operative Therapy - DocWire News - March 29th, 2023
- Higher Prevalence of Sarcopenia Reported in Patients with Rheumatoid Arthritis - Rheumatology Network - October 7th, 2022
- Exploring the Relationship Between Psoriatic Arthritis and Psoriasis - Dermatology Times - October 7th, 2022
- Are Tomatoes Bad For Arthritis? Here's What An MD Has To Say - Women's Health - October 7th, 2022
- Tocilizumab for Treating ICI-Induced Arthritis and Colitis - DocWire News - October 7th, 2022
- Why Arthritis Is A Clear And Present Danger, And How We Can Fight It - CNBCTV18 - October 7th, 2022
- Arthritis: Five cruciferous veg 'block inflammatory process' - backed by 10-year study - Express - October 7th, 2022
- 5 Exercise Habits for Arthritis in Your 50s - Eat This, Not That - October 7th, 2022
- Arthritis: 8 types of fish can cause acid crystals to build up in joints - 'very painful' - Express - October 7th, 2022
- EMA Issues Positive Opinion on the Safety of Filgotinib - Medscape - October 7th, 2022
- Lamb of God's Willie Adler on their new album Omens - Guitar.com - October 7th, 2022
- Eat Your Way to Stronger Bones & Healthy Joints - Daniel Island News - October 7th, 2022
- Long COVID could be linked to a totally different (and common) virus, new study finds - Fortune - October 7th, 2022
- My body hurt so much I thought I had arthritis & I started forgetting people it was the menopause, says K... - The Sun - October 7th, 2022
- 'Terrified' nan cant afford heating despite painful arthritis and will do 'Christmas shopping at Poundland' - Lincolnshire Live - October 7th, 2022
- Dirt & Glory's Alex Moss Cherishes the 'Real World Impact' of His Role | LBBOnline - Little Black Book - LBBonline - October 7th, 2022
- Benefits of castor oil: Castor oil is very useful in arthritis, know its health benefits - Hunt Daily News - October 7th, 2022
- How to tell if you have rheumatoid arthritis - Medical News Today - August 3rd, 2022
- What is the link between hemophilia and rheumatoid arthritis? - Medical News Today - August 3rd, 2022
- Abortion bans are harming women with cancer and arthritis. A Portland woman fears it can happen here. - Bangor Daily News - August 3rd, 2022
- These 10 diseases including thyroid-arthritis will remain under control, just drink water every day like this - News Day Express - August 3rd, 2022
- Repairing and replacing, not removing, is the future of orthopedics: Dr. Kevin Stone - Becker's Orthopedic & Spine - August 3rd, 2022
- Osteoarthritis in the wrist: Symptoms, diagnosis, and treatment - Medical News Today - August 3rd, 2022
- J&J's Stelara (ustekinumab) Approved By FDA To Treat Pediatric Patients With Active Psoriatic Arthritis - Benzinga - August 3rd, 2022
- NIAMS Awards Two Fiscal Year 2021 Supplements to Advance Research (STAR) From Projects to Programs Enhancing NIH Support for Early-Career Stage... - August 3rd, 2022
- eQcell and Ag Capital Canada Announce Completion of Capital Raise - BioSpace - August 3rd, 2022
- Altamira Therapeutics Delivery Platform with siRNA Shown to be Effective Treatment for Osteoarthritis as Published in Peer-Reviewed Journal - BioSpace - August 3rd, 2022
- Tamara was just 28 when she was diagnosed with a condition affecting 2.2 million Australians - 9News - August 3rd, 2022
- Debunking common myths about arthritis - ASBMB Today - May 8th, 2022
- Some arthritis drugs may reduce Alzheimer's and related dementias risk in those with heart disease - National Institute on Aging - May 8th, 2022
- Peng Thim Fan, MD: Reactive Arthritis and Long Covid-19 - MD Magazine - May 8th, 2022
- United Rheumatology and CreakyJoints Launch the Rheumatoid Arthritis Wellness Center - Business Wire - May 8th, 2022